                         SEQUENCE LISTING

<110>  BHATTACHARYAM et al.
 
<120>  MODIFIED KISSPEPTIN RECEPTOR AGONISTS FOR FATTY LIVER DISEASE

<130>  15290-015PC0

<150>  US 63/007,071
<151>  2020-04-08

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  1

Ser Ser Pro Cys Pro Pro Val Glu Gly Pro Ala Gly Arg Gln Arg Pro 
1               5                   10                  15      


Leu Cys Ala Ser Arg Ser Arg Leu Ile Pro Ala Pro Arg Gly Ala Val 
            20                  25                  30          


Leu Val Gln Arg Glu Lys Asp Leu Ser Thr Tyr Asn Trp Asn Ser Phe 
        35                  40                  45              


Gly Leu Arg Tyr 
    50          


<210>  2
<211>  54
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  2

Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser Arg Gln Gln 
1               5                   10                  15      


Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala Pro Gln Gly 
            20                  25                  30          


Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr Asn Trp Asn 
        35                  40                  45              


Ser Phe Gly Leu Arg Phe 
    50                  


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  3

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  4

Tyr Trp Asn Thr Phe Gly Leu Arg Trp 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  5

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  6

Trp Asn Trp Asn Ser Phe Ser Leu Arg Phe 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  7

Tyr Asn Trp Arg Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  8

Tyr Asn Trp Asn Ser Phe Leu Arg Phe 
1               5                   


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  9

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  10

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  11

Tyr Trp Asn Thr Phe Gly Leu Arg Trp 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  12

Tyr Trp Asn Thr Phe Gly Leu Arg Trp 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<400>  13

Tyr Trp Asn Thr Phe Gly Leu Arg Trp 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  14

Tyr Trp Asn Thr Phe Gly Ala Arg Trp 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' CH3-NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  15

Tyr Trp Asn Ser Phe Gly Leu Arg Trp 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  16

Tyr Trp Asn Thr Phe Gly Leu Arg Trp 
1               5                   


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Me

<400>  17

Tyr Trp Asn Thr Phe Gly Arg Trp 
1               5               


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  18

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  19

Ala Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  20

Tyr Ala Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  21

Tyr Asn Ala Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  22

Tyr Asn Trp Ala Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  23

Tyr Asn Trp Asn Ala Phe Gly Leu Arg Phe 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  24

Tyr Asn Trp Asn Ser Ala Gly Leu Arg Phe 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  25

Tyr Asn Trp Asn Ser Phe Ala Leu Arg Phe 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  26

Tyr Asn Trp Asn Ser Phe Gly Ala Arg Phe 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  27

Tyr Asn Trp Asn Ser Phe Gly Leu Ala Phe 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  28

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Ala 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  29

Phe Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  30

Tyr Asp Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  31

Tyr Asn Trp Asp Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  32

Tyr Asn Trp Asn Thr Phe Gly Leu Arg Phe 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  33

Tyr Asn Trp Asn Ser Tyr Gly Leu Arg Phe 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  34

Tyr Asn Trp Asn Ser Phe Gly Ile Arg Phe 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  35

Tyr Asn Trp Asn Ser Phe Gly Leu Lys Phe 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  3' NH2

<400>  36

Tyr Asn Trp Asn Ser Phe Gly Leu Arg His 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<400>  37

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-amino acid

<400>  38

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  D-amino acid

<400>  39

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  aza

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Me

<400>  40

Tyr Trp Asn Thr Phe Gly Leu Arg Trp 
1               5                   


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  41

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Palm-gamma

<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  Psi[Tz]

<400>  42

Tyr Lys Asp Trp Gly Leu Arg Tyr 
1               5               


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Palm-gamma

<220>
<221>  MOD_RES
<222>  (8)..(9)
<223>  Psi[Tz]

<400>  43

Tyr Asn Lys Asp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Palm-gamma

<220>
<221>  MOD_RES
<222>  (8)..(9)
<223>  Psi[Tz]

<400>  44

Asp Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Palm-gamma

<220>
<221>  MOD_RES
<222>  (8)..(9)
<223>  Psi[Tz]

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Me

<400>  45

Asp Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10      


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (7)..(8)
<223>  Psi[Tz]

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  46

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Tyr 
1               5                   10  


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gcagagccag gagaactttg ag                                                22


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
tttgattttc ttcccttcat gca                                               23


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
gatgacgtgg caaagaacag                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
tcctcggggt cctgagttat                                                   20


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
atgggcggaa tggtctcttt c                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
tggggacctt gtcttcatca t                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
ggaggtggtg atagccggta t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
tgggtaatcc atagagccca g                                                 21


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
atccgctggc taagagacaa cc                                                22


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
tgcactgggc tcccaataag g                                                 21


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
aaaaagccaa cgtatggatt ccg                                               23


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
cagcaaggta gatccggga                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
agcattcaac gccaggttc                                                    19


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
cgagtctgtc agttcaatac caa                                               23


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
ccactgtttt gggactctct                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
cgggtgtgtt cttcaaagtc                                                   20


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
cccagacaga agtcatagcc ac                                                22


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
gccttgcctt tgttcagtat c                                                 21


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
aatgagtagc agcaggtgag tg                                                22


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
gaagccagct ctctcttcct c                                                 21


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
cgcttgagtc ggcaaagaaa                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
tgatactgtc acccggctct                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
aagtgctgcc gtcattttct                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
gtggcaatga tctcaacacg                                                   20


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
tgacgtcact ggagttgtac gg                                                22


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
ggttcatgtc atggatggtg c                                                 21


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
ctgccacaga cgtcactttc                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
acataccagc ggtccacact                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
agctgctgct tctcctctgt                                                   20


<210>  76
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
gcataccgcg attcctttt                                                    19


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
cgacatgagt tcctttatga tggg                                              24


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
tgtgatctct tgcacggctt                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
gcagggttcc aacgatgttg                                                   20


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
gcagccatcg actaggacag a                                                 21


<210>  81
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
ccttgcaaac tggagagtga ca                                                22


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
aggcaaagtg atcgctctgg t                                                 21


<210>  83
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
caaccaacaa gtgatattct ccatg                                             25


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
gatccacact ctccagctgc a                                                 21


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
actgggacga catggaaaag                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
gttcagtggt gcctctgtca                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
gctgctctca aggttgttcg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
ccttttcctt ccgtttctcc                                                   20


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  89

Xaa Asn Trp Asn Ser Xaa Xaa Leu Xaa Phe 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  91

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Psi(CSNH)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  92

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Psi(CH2NH)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  93

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Psi(NHCO)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  94

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  95

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  96

Xaa Asn Xaa Asn Ser Phe Xaa Leu Xaa Phe 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<400>  97

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  98

Tyr Asn Ser Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  99

Tyr Asn Thr Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  100

Tyr Asn Ile Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Cha

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  101

Tyr Asn Xaa Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Pya(3)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  102

Tyr Asn Xaa Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Pya(4)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  103

Tyr Asn Xaa Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Nal(2)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  104

Tyr Asn Xaa Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  105

Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  3' NH2

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-Pya(4)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aza

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Me

<400>  106

Tyr Asn Xaa Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


