                         SEQUENCE LISTING

<110>  Valneva Austria GmbH
       Pfizer Inc.
 
<120>  Compositions comprising three OspA fusion proteins for medical 
       use

<130>  I0422.70135WO00

<150>  EP 20169147.4
<151>  2020-04-09

<150>  EP 20169148.2
<151>  2020-04-09

<150>  EP 20169642.4
<151>  2020-04-15

<150>  EP 20187283.5
<151>  2020-07-22

<150>  EP 20202816.3
<151>  2020-10-20

<150>  US 63/152582
<151>  2021-02-23

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  LIPID
<222>  (1)..(1)

<220>
<223>  Synthetic

<400>  1

Cys Ser Ser Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr 
1               5                   10                  15      


Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly 
            20                  25                  30          


Ser Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys 
        35                  40                  45              


Val Ala Asn Asp Lys Thr Thr Leu Val Val Lys Cys Gly Thr Val Thr 
    50                  55                  60                  


Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn 
65                  70                  75                  80  


Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser 
                85                  90                  95      


Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp 
            100                 105                 110         


Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser 
        115                 120                 125             


Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp 
    130                 135                 140                 


Glu Ile Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Glu Lys 
                165                 170                 175     


Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys Leu 
            180                 185                 190         


Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu Val 
        195                 200                 205             


Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val Thr 
    210                 215                 220                 


Leu Glu Val Lys Cys Gly Thr Val Thr Leu Ser Lys Glu Ile Ala Lys 
225                 230                 235                 240 


Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala 
                245                 250                 255     


Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile 
            260                 265                 270         


Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln Asp 
        275                 280                 285             


Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly 
    290                 295                 300                 


Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Cys Asn Ala Leu Lys 
305                 310                 315                 320 


<210>  2
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  LIPID
<222>  (1)..(1)

<220>
<223>  Synthetic

<400>  2

Cys Ser Ser Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu 
1               5                   10                  15      


Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly 
            20                  25                  30          


Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr 
        35                  40                  45              


Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Val 
    50                  55                  60                  


Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn 
65                  70                  75                  80  


Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser 
                85                  90                  95      


Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn 
            100                 105                 110         


Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser 
        115                 120                 125             


Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp 
    130                 135                 140                 


Glu Leu Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Glu Lys 
                165                 170                 175     


Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn Gly Thr Thr Leu 
            180                 185                 190         


Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr Lys Ala Val Glu 
        195                 200                 205             


Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu Val Gly Gly Lys 
    210                 215                 220                 


Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser Lys Asn Ile 
225                 230                 235                 240 


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
                245                 250                 255     


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
            260                 265                 270         


Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys 
        275                 280                 285             


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
    290                 295                 300                 


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Cys Ala Ala 
305                 310                 315                 320 


Leu Lys 
        


<210>  3
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  LIPID
<222>  (1)..(1)

<220>
<223>  Synthetic

<400>  3

Cys Ser Ser Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu 
1               5                   10                  15      


Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly 
            20                  25                  30          


Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr 
        35                  40                  45              


Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Val 
    50                  55                  60                  


Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn 
65                  70                  75                  80  


Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser 
                85                  90                  95      


Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn 
            100                 105                 110         


Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser 
        115                 120                 125             


Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp 
    130                 135                 140                 


Glu Leu Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Glu Lys 
                165                 170                 175     


Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn Gly Thr Thr Leu 
            180                 185                 190         


Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr Lys Ala Val Glu 
        195                 200                 205             


Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu Val Gly Gly Lys 
    210                 215                 220                 


Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser Lys Asn Ile 
225                 230                 235                 240 


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
                245                 250                 255     


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
            260                 265                 270         


Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys 
        275                 280                 285             


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
    290                 295                 300                 


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Cys Ala Ala 
305                 310                 315                 320 


Leu Lys 
        


<210>  4
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaacgaaaa gggcgaagtc agcgaaaaaa tcattacccg cgcagacggc      120

acccgcctgg aatacaccgg catcaaatcg gacggcagcg gcaaagcgaa agaagttctg      180

aaaaacttta ccctggaagg caaagtcgca aatgataaaa ccaccctggt ggtgaaatgc      240

ggcaccgtta cgctgagcaa aaacattagt aaatccggtg aagtctctgt ggaactgaat      300

gataccgaca gctctgcggc caccaagaaa accgcagctt ggaactcagg cacctcgacg      360

ctgaccatta cggttaatag caagaaaacc aaagatctgg tcttcacgaa agaaaacacc      420

atcacggtgc agcaatatga cagcaatggt accaaactgg aaggctccgc tgtggaaatc      480

acgaaactgg atgaaatctg taatgctctg aaaggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattca acgaaaaagg cgaactgtcg      600

gcgaaaacga tgacgcgtga aaacggcacc aaactggaat atacggaaat gaaaagcgat      660

ggcaccggta aagcgaaaga agttctgaaa aactttaccc tggaaggcaa agtcgccaat      720

gacaaagtca ccctggaagt gaaatgcggc accgttacgc tgtcaaaaga aattgcaaaa      780

tcgggtgaag tgaccgttgc tctgaacgat acgaatacca cgcaagcgac caagaaaacc      840

ggcgcctggg acagcaaaac ctctacgctg accattagtg ttaatagcaa gaaaaccacg      900

cagctggtct tcaccaaaca agatacgatc accgtgcaga aatacgacag tgcgggtacc      960

aacctggaag gcacggctgt tgaaatcaaa accctggacg aactgtgtaa cgccctgaaa     1020


<210>  5
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaatgctaa gggcgaactg agcgaaaaaa cgatcctgcg tgcgaatggc      120

acccgtctgg aatacaccga aatcaaatcc gatggtacgg gcaaagcaaa ggaagtcctg      180

aaagattttg ctctggaagg taccctggcg gccgacaaaa ccacgctgaa ggtgacgtgc      240

ggcaccgtgg ttctgagcaa acatattccg aactctggtg aaatcaccgt tgaactgaac      300

gatagcaatt ctacgcaggc aaccaaaaag acgggcaaat gggacagtaa tacctccacg      360

ctgaccattt cagtcaactc gaaaaagacc aaaaatattg tgttcacgaa ggaagatacg      420

atcaccgttc aaaaatatga ctccgcgggc accaacctgg aaggcaatgc cgtcgaaatc      480

aaaaccctgg atgaactgtg taacgccctg aagggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattca acgaaaaagg cgaagtgagc      600

gaaaaaattc tgacccgtag caatggcacc accctggaat atagccagat gaccgatgca      660

gaaaatgcaa ccaaagcagt tgaaaccctg aaaaacggta ttaaactgcc tggtaatctg      720

gttggtggta aaaccaaact gaccgttacc tgtggcaccg ttaccctgag caaaaacatt      780

agcaaaagcg gtgaaattac cgtggcactg aatgataccg aaaccacacc ggcagacaaa      840

aaaaccggtg aatggaaaag cgataccagc accctgacca ttagtaaaaa tagccagaaa      900

acaaaacagc tggtgtttac caaagaaaac accattaccg tgcagaatta taaccgtgca      960

ggtaatgcac tggaaggtag tccggcagaa attaaagatc tggcagaact gtgtgcagcc     1020

ctgaaataa                                                             1029


<210>  6
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaacgaaaa gggcgaaatc tcagaaaaaa ccatcgtccg cgctaacggc      120

acccgcctgg aatacaccga catcaaatca gacaagaccg gtaaagcgaa ggaagttctg      180

aaagatttta cgctggaagg taccctggca gcagacggta aaaccacgct gaaggtgacc      240

tgcggtaccg ttacgctgtc caaaaacatt agtaagtccg gcgaaatcac ggtcgccctg      300

gatgacaccg atagctctgg caacaaaaag agcggtacct gggattcagg cacctcgacg      360

ctgaccattt ctaaaaatcg tacgaaaacc aagcagctgg tcttcacgaa agaagatacg      420

atcaccgtgc aaaactatga cagcgcaggt accaatctgg aaggcaaagc tgtggaaatt      480

accacgctga aagaactgtg taatgctctg aaaggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattca acggcaaagg tgaaacgagc      600

gaaaagacca tcgtgcgtgc gaacggtacc cgcctggaat atacggacat taaatcggac      660

ggcagcggca aagcaaagga agtcctgaaa gattttacgc tggaaggtac cctggcagca      720

gacggtaaaa ccacgctgaa ggtgacgtgc ggcaccgtgg ttctgtcaaa aaacattctg      780

aagtcgggtg aaatcaccgc agctctggat gacagcgata ccacgcgtgc tacgaaaaag      840

accggtaaat gggatagcaa gacctctacg ctgaccatta gtgtcaactc ccagaaaacg      900

aagaatctgg tgttcaccaa agaagatacg atcaccgttc aacgctatga cagtgcgggc      960

accaacctgg aaggcaaagc cgttgaaatt accacgctga aagaactgtg taatgctctg     1020

aaa                                                                   1023


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Ser Lys Glu Lys Asn Lys 
1               5                   10                  15      


Asp Gly Lys Tyr Ser 
            20      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp 
1               5                   10      


