                         SEQUENCE LISTING

<110>  DISARM THERAPEUTICS, INC.
 
<120>  INHIBITORS OF SARM1

<130>  X22918_WO

<150>  63/007,773
<151>  2020-04-09

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  13028
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
gcgatcgcgg ctcccgacat cttggaccat tagctccaca ggtatcttct tccctctagt       60

ggtcataaca gcagcttcag ctacctctca attcaaaaaa cccctcaaga cccgtttaga      120

ggccccaagg ggttatgcta tcaatcgttg cgttacacac acaaaaaacc aacacacatc      180

catcttcgat ggatagcgat tttattatct aactgctgat cgagtgtagc cagatctagt      240

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      300

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      360

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      420

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      480

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      540

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg ctgatgcggt      600

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      660

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      720

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      780

atataagcag agctggttta gtgaaccgtc agatcagatc tttgtcgatc ctaccatcca      840

ctcgacacac ccgccagcgg ccgctgccaa gcttccgagc tctcgaattc aaaggaggta      900

cccaccatgg ccatgcatca ccaccaccat catagctccg gcgtcgacct cggcaccgag      960

aatttatatt tccaaagcgg cctcaatgat atcttcgagg cccagaagat cgagtggcac     1020

gagggcagct ccgacctcgc cgtgcccggt cccgatggag gcggaggcac tggtccttgg     1080

tgggctgctg gcggcagagg ccctagagaa gtgagccccg gtgctggcac cgaggtgcaa     1140

gacgctctgg agagggctct gcccgaactg cagcaagctc tgtccgcttt aaagcaagct     1200

ggaggagcta gagccgtcgg cgccggactg gccgaagtgt tccagctcgt ggaggaagct     1260

tggttattac ccgctgtggg aagagaggtc gcccaaggtc tgtgtgacgc cattcgtctg     1320

gacggaggtt tagacttatt actgaggctg ctgcaagctc ccgaactgga gacaagggtc     1380

caagctgctc gtctgctgga gcagatcctc gtggccgaga atcgtgacag agtggctaga     1440

atcggtttag gcgtcatcct caatttagcc aaagagaggg agcccgttga gctggccaga     1500

agcgtcgctg gcatcctcga gcacatgttc aagcattccg aggagacttg tcagagactg     1560

gtcgccgccg gaggactcga tgctgtttta tactggtgca gaaggacaga ccccgcttta     1620

ctgaggcatt gtgctctggc cctcggcaat tgcgctttac atggaggcca agccgtccag     1680

agaaggatgg tggagaaaag agccgccgag tggctgttcc ctttagcctt ctccaaagaa     1740

gacgaactgt tacgtctgca tgcttgtctc gctgtcgctg ttttagccac caacaaggag     1800

gtggaaaggg aagtggaaag aagcggaaca ctggctttag tcgaacctct ggtggcttct     1860

ttagatcccg gaaggtttgc cagatgtctg gtcgacgcca gcgatacctc ccaaggaaga     1920

ggccccgacg atctccagag actggtgcct ctgctggaca gcaatcgtct ggaggcccaa     1980

tgtattggcg ccttctatct ctgcgccgaa gccgccatca agtctttaca aggtaagacc     2040

aaggtgttct ccgacattgg agccatccaa tctttaaaga ggctggtgag ctattccacc     2100

aacggcacaa aaagcgcttt agccaaaaga gctttaagac tgctgggcga agaggtgcct     2160

aggcccattt taccttccgt gcctagctgg aaggaggccg aggtgcagac ttggctgcag     2220

cagatcggct ttagcaaata ttgcgaatcc tttagggagc agcaagttga cggcgattta     2280

ttattaaggc tgaccgagga agagctccag acagatttag gcatgaaaag cggcatcact     2340

cgtaagaggt tctttcgtga gctcaccgaa ctgaagacct tcgccaacta ctccacttgt     2400

gatcgtagca atttagctga ttggctcgga tccctcgatc ccagatttcg tcagtacacc     2460

tatggactcg tctcttgtgg actggacaga tctttactgc atcgtgtgag cgagcaacag     2520

ctgctggaag attgcggcat ccatttagga gtgcacagag ccagaattct gaccgccgct     2580

agagagatgc tgcattcccc tctcccttgt accggaggca agcctagcgg agacaccccc     2640

gacgtgttca tcagctatcg tagaaacagc ggaagccagc tggcctcttt actgaaggtc     2700

catttacagc tgcacggatt tagcgtcttc atcgacgtgg agaaactgga ggctggcaag     2760

ttcgaggaca agctgatcca gtccgtgatg ggcgctagga atttcgtttt agtgctcagc     2820

cccggcgctc tggataaatg catgcaagat catgactgta aggactgggt ccacaaggaa     2880

atcgtgaccg ctctgtcttg tggcaagaac atcgtcccca tcatcgacgg cttcgaatgg     2940

cccgagcctc aagttctccc cgaagatatg caagctgttt taaccttcaa tggaatcaag     3000

tggagccacg agtaccaaga agccacaatc gagaagatca ttcgttttct gcaaggtaga     3060

tcctccagag attcctccgc tggcagcgac acatctttag agggcgccgc ccctatgggt     3120

cctacctaat aatctagaag ttgtctcctc ctgcactgac tgactgatac aatcgatttc     3180

tggatccgca ggcctctgct agcttgactg actgagatac agcgtacctt cagctcacag     3240

acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat     3300

gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata     3360

aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg     3420

aggtttttta aagcaagtaa aacctctaca aatgtggtat tggcccatct ctatcggtat     3480

cgtagcataa ccccttgggg cctctaaacg ggtcttgagg ggttttttgt gcccctcggg     3540

ccggattgct atctaccggc attggcgcag aaaaaaatgc ctgatgcgac gctgcgcgtc     3600

ttatactccc acatatgcca gattcagcaa cggatacggc ttccccaact tgcccacttc     3660

catacgtgtc ctccttacca gaaatttatc cttaaggtcg tcagctatcc tgcaggcgat     3720

ctctcgattt cgatcaagac attcctttaa tggtcttttc tggacaccac taggggtcag     3780

aagtagttca tcaaactttc ttccctccct aatctcattg gttaccttgg gctatcgaaa     3840

cttaattaac cagtcaagtc agctacttgg cgagatcgac ttgtctgggt ttcgactacg     3900

ctcagaattg cgtcagtcaa gttcgatctg gtccttgcta ttgcacccgt tctccgatta     3960

cgagtttcat ttaaatcatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     4020

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     4080

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     4140

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     4200

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     4260

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     4320

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     4380

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     4440

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     4500

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     4560

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     4620

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     4680

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     4740

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     4800

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     4860

catttaaatt tccgaactct ccaaggccct cgtcggaaaa tcttcaaacc tttcgtccga     4920

tccatcttgc aggctacctc tcgaacgaac tatcgcaagt ctcttggccg gccttgcgcc     4980

ttggctattg cttggcagcg cctatcgcca ggtattactc caatcccgaa tatccgagat     5040

cgggatcacc cgagagaagt tcaacctaca tcctcaatcc cgatctatcc gagatccgag     5100

gaatatcgaa atcggggcgc gcctggtgta ccgagaacga tcctctcagt gcgagtctcg     5160

acgatccata tcgttgcttg gcagtcagcc agtcggaatc cagcttggga cccaggaagt     5220

ccaatcgtca gatattgtac tcaagcctgg tcacggcagc gtaccgatct gtttaaacct     5280

agatattgat agtctgatcg gtcaacgtat aatcgagtcc tagcttttgc aaacatctat     5340

caagagacag gatcagcagg aggctttcgc atgagtattc aacatttccg tgtcgccctt     5400

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     5460

gtaaaagatg ctgaagatca gttgggtgcg cgagtgggtt acatcgaact ggatctcaac     5520

agcggtaaga tccttgagag ttttcgcccc gaagaacgct ttccaatgat gagcactttt     5580

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     5640

cgccgcatac actattctca gaatgacttg gttgagtatt caccagtcac agaaaagcat     5700

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     5760

actgcggcca acttacttct gacaacgatt ggaggaccga aggagctaac cgcttttttg     5820

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     5880

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac cttgcgtaaa     5940

ctattaactg gcgaactact tactctagct tcccggcaac agttgataga ctggatggag     6000

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     6060

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     6120

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     6180

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta accgattcta     6240

ggtgcattgg cgcagaaaaa aatgcctgat gcgacgctgc gcgtcttata ctcccacata     6300

tgccagattc agcaacggat acggcttccc caacttgccc acttccatac gtgtcctcct     6360

taccagaaat ttatccttaa gatcccgaat cgtttaaact cgactctggc tctatcgaat     6420

ctccgtcgtt tcgagcttac gcgaacagcc gtggcgctca tttgctcgtc gggcatcgaa     6480

tctcgtcagc tatcgtcagc ttaccttttt ggcagcgatc gcggctcccg acatcttgga     6540

ccattagctc cacaggtatc ttcttccctc tagtggtcat aacagcagct tcagctacct     6600

ctcaattcaa aaaacccctc aagacccgtt tagaggcccc aaggggttat gctatcaatc     6660

gttgcgttac acacacaaaa aaccaacaca catccatctt cgatggatag cgattttatt     6720

atctaactgc tgatcgagtg tagccagatc tagtaatcaa ttacggggtc attagttcat     6780

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg     6840

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata     6900

gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta     6960

catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc     7020

gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca gtacatctac     7080

gtattagtca tcgctattac catgctgatg cggttttggc agtacatcaa tgggcgtgga     7140

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg     7200

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg     7260

caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctgg tttagtgaac     7320

cgtcagatca gatctttgtc gatcctacca tccactcgac acacccgcca gcggccgctg     7380

ccaagcttcc gagctctcga attcaaagga ggtacccacc atggccatgc atcaccacca     7440

ccatcatagc tccggcgtcg acctcggcac cgagaattta tatttccaaa gcggcctcaa     7500

tgatatcttc gaggcccaga agatcgagtg gcacgagggc agctccgacc tcgccgtgcc     7560

cggtcccgat ggaggcggag gcactggtcc ttggtgggct gctggcggca gaggccctag     7620

agaagtgagc cccggtgctg gcaccgaggt gcaagacgct ctggagaggg ctctgcccga     7680

actgcagcaa gctctgtccg ctttaaagca agctggagga gctagagccg tcggcgccgg     7740

actggccgaa gtgttccagc tcgtggagga agcttggtta ttacccgctg tgggaagaga     7800

ggtcgcccaa ggtctgtgtg acgccattcg tctggacgga ggtttagact tattactgag     7860

gctgctgcaa gctcccgaac tggagacaag ggtccaagct gctcgtctgc tggagcagat     7920

cctcgtggcc gagaatcgtg acagagtggc tagaatcggt ttaggcgtca tcctcaattt     7980

agccaaagag agggagcccg ttgagctggc cagaagcgtc gctggcatcc tcgagcacat     8040

gttcaagcat tccgaggaga cttgtcagag actggtcgcc gccggaggac tcgatgctgt     8100

tttatactgg tgcagaagga cagaccccgc tttactgagg cattgtgctc tggccctcgg     8160

caattgcgct ttacatggag gccaagccgt ccagagaagg atggtggaga aaagagccgc     8220

cgagtggctg ttccctttag ccttctccaa agaagacgaa ctgttacgtc tgcatgcttg     8280

tctcgctgtc gctgttttag ccaccaacaa ggaggtggaa agggaagtgg aaagaagcgg     8340

aacactggct ttagtcgaac ctctggtggc ttctttagat cccggaaggt ttgccagatg     8400

tctggtcgac gccagcgata cctcccaagg aagaggcccc gacgatctcc agagactggt     8460

gcctctgctg gacagcaatc gtctggaggc ccaatgtatt ggcgccttct atctctgcgc     8520

cgaagccgcc atcaagtctt tacaaggtaa gaccaaggtg ttctccgaca ttggagccat     8580

ccaatcttta aagaggctgg tgagctattc caccaacggc acaaaaagcg ctttagccaa     8640

aagagcttta agactgctgg gcgaagaggt gcctaggccc attttacctt ccgtgcctag     8700

ctggaaggag gccgaggtgc agacttggct gcagcagatc ggctttagca aatattgcga     8760

atcctttagg gagcagcaag ttgacggcga tttattatta aggctgaccg aggaagagct     8820

ccagacagat ttaggcatga aaagcggcat cactcgtaag aggttctttc gtgagctcac     8880

cgaactgaag accttcgcca actactccac ttgtgatcgt agcaatttag ctgattggct     8940

cggatccctc gatcccagat ttcgtcagta cacctatgga ctcgtctctt gtggactgga     9000

cagatcttta ctgcatcgtg tgagcgagca acagctgctg gaagattgcg gcatccattt     9060

aggagtgcac agagccagaa ttctgaccgc cgctagagag atgctgcatt cccctctccc     9120

ttgtaccgga ggcaagccta gcggagacac ccccgacgtg ttcatcagct atcgtagaaa     9180

cagcggaagc cagctggcct ctttactgaa ggtccattta cagctgcacg gatttagcgt     9240

cttcatcgac gtggagaaac tggaggctgg caagttcgag gacaagctga tccagtccgt     9300

gatgggcgct aggaatttcg ttttagtgct cagccccggc gctctggata aatgcatgca     9360

agatcatgac tgtaaggact gggtccacaa ggaaatcgtg accgctctgt cttgtggcaa     9420

gaacatcgtc cccatcatcg acggcttcga atggcccgag cctcaagttc tccccgaaga     9480

tatgcaagct gttttaacct tcaatggaat caagtggagc cacgagtacc aagaagccac     9540

aatcgagaag atcattcgtt ttctgcaagg tagatcctcc agagattcct ccgctggcag     9600

cgacacatct ttagagggcg ccgcccctat gggtcctacc taataatcta gaagttgtct     9660

cctcctgcac tgactgactg atacaatcga tttctggatc cgcaggcctc tgctagcttg     9720

actgactgag atacagcgta ccttcagctc acagacatga taagatacat tgatgagttt     9780

ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct     9840

attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt     9900

cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc     9960

tacaaatgtg gtattggccc atctctatcg gtatcgtagc ataacccctt ggggcctcta    10020

aacgggtctt gaggggtttt ttgtgcccct cgggccggat tgctatctac cggcattggc    10080

gcagaaaaaa atgcctgatg cgacgctgcg cgtcttatac tcccacatat gccagattca    10140

gcaacggata cggcttcccc aacttgccca cttccatacg tgtcctcctt accagaaatt    10200

tatccttaag gtcgtcagct atcctgcagg cgatctctcg atttcgatca agacattcct    10260

ttaatggtct tttctggaca ccactagggg tcagaagtag ttcatcaaac tttcttccct    10320

ccctaatctc attggttacc ttgggctatc gaaacttaat taaccagtca agtcagctac    10380

ttggcgagat cgacttgtct gggtttcgac tacgctcaga attgcgtcag tcaagttcga    10440

tctggtcctt gctattgcac ccgttctccg attacgagtt tcatttaaat catgtgagca    10500

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg    10560

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg    10620

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt    10680

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt    10740

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc    10800

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt    10860

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt    10920

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc    10980

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa    11040

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt    11100

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct    11160

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta    11220

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa    11280

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc    11340

tcagcgatct gtctatttcg ttcatccata gttgcattta aatttccgaa ctctccaagg    11400

ccctcgtcgg aaaatcttca aacctttcgt ccgatccatc ttgcaggcta cctctcgaac    11460

gaactatcgc aagtctcttg gccggccttg cgccttggct attgcttggc agcgcctatc    11520

gccaggtatt actccaatcc cgaatatccg agatcgggat cacccgagag aagttcaacc    11580

tacatcctca atcccgatct atccgagatc cgaggaatat cgaaatcggg gcgcgcctgg    11640

tgtaccgaga acgatcctct cagtgcgagt ctcgacgatc catatcgttg cttggcagtc    11700

agccagtcgg aatccagctt gggacccagg aagtccaatc gtcagatatt gtactcaagc    11760

ctggtcacgg cagcgtaccg atctgtttaa acctagatat tgatagtctg atcggtcaac    11820

gtataatcga gtcctagctt ttgcaaacat ctatcaagag acaggatcag caggaggctt    11880

tcgcatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct    11940

tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg    12000

tgcgcgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg    12060

ccccgaagaa cgctttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt    12120

atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga    12180

cttggttgag tattcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga    12240

attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac    12300

gattggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg    12360

ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac    12420

gatgcctgta gcaatggcaa caaccttgcg taaactatta actggcgaac tacttactct    12480

agcttcccgg caacagttga tagactggat ggaggcggat aaagttgcag gaccacttct    12540

gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg    12600

gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat    12660

ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg    12720

tgcctcactg attaagcatt ggtaaccgat tctaggtgca ttggcgcaga aaaaaatgcc    12780

tgatgcgacg ctgcgcgtct tatactccca catatgccag attcagcaac ggatacggct    12840

tccccaactt gcccacttcc atacgtgtcc tccttaccag aaatttatcc ttaagatccc    12900

gaatcgttta aactcgactc tggctctatc gaatctccgt cgtttcgagc ttacgcgaac    12960

agccgtggcg ctcatttgct cgtcgggcat cgaatctcgt cagctatcgt cagcttacct    13020

ttttggca                                                             13028


