                               SEQUENCE LISTING

<110> LUNG BIOTECHNOLOGY PBC
 
<120> MODULAR SYNTHETIC RECEPTORS AND METHODS OF USE

<130> 080618-2005

<140> PCT/US2021/025778
<141> 2021-04-05

<150> 63/005,739
<151> 2020-04-06

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 832
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile Pro 
                245                 250                 255     


Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp 
            260                 265                 270         


Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys Gly 
        275                 280                 285             


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
    290                 295                 300                 


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
305                 310                 315                 320 


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
                325                 330                 335     


Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
            340                 345                 350         


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
        355                 360                 365             


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
    370                 375                 380                 


Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu 
385                 390                 395                 400 


Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His 
                405                 410                 415     


Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe 
            420                 425                 430         


Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
        435                 440                 445             


Ala Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val Lys 
    450                 455                 460                 


Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg Glu 
465                 470                 475                 480 


Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp 
                485                 490                 495     


Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala Thr 
            500                 505                 510         


Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn 
        515                 520                 525             


Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro 
    530                 535                 540                 


Pro Pro Ala Gln Leu His Phe Met Tyr Val Ala Ala Ala Ala Phe Val 
545                 550                 555                 560 


Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg 
                565                 570                 575     


Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu Asp Lys Ser Lys 
            580                 585                 590         


Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly 
        595                 600                 605             


Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr 
    610                 615                 620                 


Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala 
625                 630                 635                 640 


Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly 
                645                 650                 655     


Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys 
            660                 665                 670         


Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg 
        675                 680                 685             


Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu 
    690                 695                 700                 


Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala 
705                 710                 715                 720 


Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln 
                725                 730                 735     


Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro 
            740                 745                 750         


Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro 
        755                 760                 765             


Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln 
    770                 775                 780                 


Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp 
785                 790                 795                 800 


Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
                805                 810                 815     


Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
            820                 825                 830         


<210> 2
<211> 833
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
    130                 135                 140                 


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
145                 150                 155                 160 


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
                165                 170                 175     


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
        195                 200                 205             


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
    210                 215                 220                 


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile 
                245                 250                 255     


Pro Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu 
            260                 265                 270         


Asp Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys 
        275                 280                 285             


Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
    290                 295                 300                 


Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
305                 310                 315                 320 


Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
                325                 330                 335     


Cys Gln Arg Ala Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
            340                 345                 350         


Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
        355                 360                 365             


Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
    370                 375                 380                 


Leu Ala Ala Gly Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln 
385                 390                 395                 400 


Leu Arg Asn Ser Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu 
                405                 410                 415     


His Thr Asn Val Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile 
            420                 425                 430         


Phe Pro Tyr Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
        435                 440                 445             


Arg Ala Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val 
    450                 455                 460                 


Lys Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg 
465                 470                 475                 480 


Glu Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile 
                485                 490                 495     


Asp Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala 
            500                 505                 510         


Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu 
        515                 520                 525             


Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro 
    530                 535                 540                 


Pro Pro Pro Ala Gln Leu His Phe Met Tyr Val Ala Ala Ala Ala Phe 
545                 550                 555                 560 


Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg 
                565                 570                 575     


Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu Asp Lys Ser 
            580                 585                 590         


Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu 
        595                 600                 605             


Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro 
    610                 615                 620                 


Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu 
625                 630                 635                 640 


Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu 
                645                 650                 655     


Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg 
            660                 665                 670         


Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr 
        675                 680                 685             


Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe 
    690                 695                 700                 


Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser 
705                 710                 715                 720 


Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His 
                725                 730                 735     


Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro 
            740                 745                 750         


Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu 
        755                 760                 765             


Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys 
    770                 775                 780                 


Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe 
785                 790                 795                 800 


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
                805                 810                 815     


Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro 
            820                 825                 830         


Gly 
    


<210> 3
<211> 822
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
                245                 250                 255     


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
            260                 265                 270         


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
        275                 280                 285             


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
    290                 295                 300                 


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
305                 310                 315                 320 


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
                325                 330                 335     


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
            340                 345                 350         


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
        355                 360                 365             


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
    370                 375                 380                 


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
385                 390                 395                 400 


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
                405                 410                 415     


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
            420                 425                 430         


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
        435                 440                 445             


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
    450                 455                 460                 


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
465                 470                 475                 480 


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
                485                 490                 495     


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
            500                 505                 510         


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
        515                 520                 525             


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
    530                 535                 540                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
545                 550                 555                 560 


Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser 
                565                 570                 575     


Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn 
            580                 585                 590         


Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu 
        595                 600                 605             


Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala 
    610                 615                 620                 


Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His 
625                 630                 635                 640 


Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn 
                645                 650                 655     


Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys 
            660                 665                 670         


Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu 
        675                 680                 685             


Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala 
    690                 695                 700                 


Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu 
705                 710                 715                 720 


Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr 
                725                 730                 735     


Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp 
            740                 745                 750         


His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile 
        755                 760                 765             


Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp 
    770                 775                 780                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
785                 790                 795                 800 


Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp 
                805                 810                 815     


Leu Asp Met Leu Pro Gly 
            820         


<210> 4
<211> 381
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala 
    130                 135                 140                 


Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Asp Lys Thr His Thr Cys 
145                 150                 155                 160 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380     


<210> 5
<211> 767
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
                325                 330                 335     


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
            340                 345                 350         


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
        355                 360                 365             


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
385                 390                 395                 400 


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
                405                 410                 415     


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
    450                 455                 460                 


Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
465                 470                 475                 480 


Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     


Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val 
            500                 505                 510         


Met Ser Tyr Leu Asn Ala Ser Gly Gly Ala Glu Ala Ala Ala Lys Glu 
        515                 520                 525             


Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Asp Lys Thr His 
    530                 535                 540                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
545                 550                 555                 560 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                565                 570                 575     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            580                 585                 590         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        595                 600                 605             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    610                 615                 620                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
625                 630                 635                 640 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                645                 650                 655     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            660                 665                 670         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        675                 680                 685             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    690                 695                 700                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
705                 710                 715                 720 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                725                 730                 735     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            740                 745                 750         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760                 765         


<210> 6
<211> 59
<212> PRT
<213> Drosophila sp.

<400> 6
Gln Leu Arg Asn Asp Phe Gln Ile His Ser Val Arg Gly Ile Lys Asn 
1               5                   10                  15      


Pro Gly Asp Glu Asp Asn Gly Glu Pro Pro Ala Asn Val Lys Tyr Val 
            20                  25                  30          


Ile Thr Gly Ile Ile Leu Val Ile Ile Ala Leu Ala Phe Phe Gly Met 
        35                  40                  45              


Val Leu Ser Thr Gln Arg Lys Arg Ala His Gly 
    50                  55                  


<210> 7
<211> 58
<212> PRT
<213> Caenorhabditis sp.

<400> 7
Gly Leu Pro Ile Thr Glu Ala Met Val Ala Val Pro Lys Arg Asn Glu 
1               5                   10                  15      


Ile Asp Glu Gly Trp Ser Arg Ser Gln Val Ile Leu Phe Ala Cys Ile 
            20                  25                  30          


Ala Phe Leu Ala Phe Gly Thr Val Val Ala Gly Val Ile Ala Lys Asn 
        35                  40                  45              


Gly Pro Glu Arg Ser Arg Lys Arg Lys Met 
    50                  55              


<210> 8
<211> 53
<212> PRT
<213> Sus sp.

<400> 8
Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val 
1               5                   10                  15      


Glu Pro Pro Pro Pro Pro Pro Leu His Phe Met Tyr Val Ala Val Val 
            20                  25                  30          


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
        35                  40                  45              


Lys Arg Arg Arg Gln 
    50              


<210> 9
<211> 53
<212> PRT
<213> Mus sp.

<400> 9
Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val 
1               5                   10                  15      


Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala 
            20                  25                  30          


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
        35                  40                  45              


Lys Arg Arg Arg Gln 
    50              


<210> 10
<211> 53
<212> PRT
<213> Homo sapiens

<400> 10
Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val 
1               5                   10                  15      


Glu Pro Pro Pro Pro Ala Gln Leu His Phe Met Tyr Val Ala Ala Ala 
            20                  25                  30          


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
        35                  40                  45              


Lys Arg Arg Arg Gln 
    50              


<210> 11
<211> 52
<212> PRT
<213> Homo sapiens

<400> 11
Gln Gly Thr Leu Ser Tyr Pro Leu Val Ser Val Val Ser Glu Ser Leu 
1               5                   10                  15      


Thr Pro Glu Arg Thr Gln Leu Leu Tyr Leu Leu Ala Val Ala Val Val 
            20                  25                  30          


Ile Ile Leu Phe Ile Ile Leu Leu Gly Val Ile Met Ala Lys Arg Lys 
        35                  40                  45              


Arg Lys His Gly 
    50          


<210> 12
<211> 52
<212> PRT
<213> Homo sapiens

<400> 12
Arg Leu Asp Phe Pro Tyr Pro Leu Arg Asp Val Arg Gly Glu Pro Leu 
1               5                   10                  15      


Glu Pro Pro Glu Pro Ser Val Pro Leu Leu Pro Leu Leu Val Ala Gly 
            20                  25                  30          


Ala Val Leu Leu Leu Val Ile Leu Val Leu Gly Val Met Val Ala Arg 
        35                  40                  45              


Arg Lys Arg Glu 
    50          


<210> 13
<211> 56
<212> PRT
<213> Homo sapiens

<400> 13
Glu Pro Leu Leu Pro Gly Pro Leu Leu Ala Val His Pro His Ala Gly 
1               5                   10                  15      


Thr Ala Pro Pro Ala Asn Gln Leu Pro Trp Pro Val Leu Cys Ser Pro 
            20                  25                  30          


Val Ala Gly Val Ile Leu Leu Ala Leu Gly Ala Leu Leu Val Leu Gln 
        35                  40                  45              


Leu Ile Arg Arg Arg Arg Arg Glu 
    50                  55      


