                         SEQUENCE LISTING
 
<110>  Agency for Science, Technology and Research  
 
<120>  ANTIGEN-BINDING PROTEIN TO SARS-CoV-2  
 
<130>  2100400  
 
<160>  361 
 
<210>  1 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1A5 light chain variable domain 
 
<400>  1 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Ala Ile Ser Cys Thr Gly Asn Ser Gly Ser Ile Ala Ser His 
             20                  25                  30          
 
Tyr Val Gln Trp Phe Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Gly Ser 
                 85                  90                  95      
 
Gly Phe Val Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  2 
<211>  109 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1A8 light chain variable domain 
 
<400>  2 
Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
  1               5                  10                  15      
 
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
             20                  25                  30          
 
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
         35                  40                  45              
 
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
     50                  55                  60                  
 
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
 65                  70                  75                  80  
 
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                 85                  90                  95      
 
Tyr Tyr Gly Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
            100                 105                  
 
<210>  3 
<211>  107 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1B2 light chain variable domain 
 
<400>  3 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Gly Ser Gly Gly Arg Ile Ala Thr Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ala Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Glu Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser His Asp Thr 
                 85                  90                  95      
 
Ser Arg Gln Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105          
 
<210>  4 
<211>  108 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1B11 light chain variable domain 
 
<400>  4 
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
  1               5                  10                  15      
 
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
             20                  25                  30          
 
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
         35                  40                  45              
 
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
     50                  55                  60                  
 
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
 65                  70                  75                  80  
 
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                 85                  90                  95      
 
Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
            100                 105              
 
<210>  5 
<211>  108 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1C2 light chain variable domain 
 
<400>  5 
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
  1               5                  10                  15      
 
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
             20                  25                  30          
 
Asn Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Leu Ser 
         35                  40                  45              
 
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Pro Gly Val Pro 
     50                  55                  60                  
 
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
 65                  70                  75                  80  
 
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                 85                  90                  95      
 
Ile Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
            100                 105              
 
<210>  6 
<211>  108 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1C3 light chain variable domain 
 
<400>  6 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Tyr 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ala Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser 
                 85                  90                  95      
 
Ser Ile Gln His Val Val Phe Gly Gly Gly Thr Gln 
            100                 105              
 
<210>  7 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1D12 light chain variable domain 
 
<400>  7 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val His Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                 85                  90                  95      
 
Ser Ala Trp Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  8 
<211>  108 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1E5 light chain variable domain 
 
<400>  8 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Leu Thr Ile Ser Cys Thr Arg Ser Ser Gly Arg Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Asp Ser 
                 85                  90                  95      
 
Gly Asn Gln Arg Val Val Phe Gly Gly Gly Thr Lys 
            100                 105              
 
<210>  9 
<211>  105 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1F4 light chain variable domain 
 
<400>  9 
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
  1               5                  10                  15      
 
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
             20                  25                  30          
 
Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Arg Leu Leu 
         35                  40                  45              
 
Met Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Glu Ser Ala Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
 65                  70                  75                  80  
 
Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Leu 
                 85                  90                  95      
 
Phe Val Val Phe Gly Gly Gly Thr Lys 
            100                 105  
 
<210>  10 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1H7 light chain variable domain 
 
<400>  10 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Val Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Glu 
                 85                  90                  95      
 
Asn Ile Arg Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  11 
<211>  103 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2C9 light chain variable domain 
 
<400>  11 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Ser Ser Pro Gly 
  1               5                  10                  15      
 
Glu Arg Ala Thr Leu Ser Cys Thr Ala Ser Gln Thr Val Gly Gly Ser 
             20                  25                  30          
 
Tyr Leu Ala Trp Tyr Gln Gln Lys Arg Gly Gln Pro Pro Arg Leu Leu 
         35                  40                  45              
 
Ile Tyr Gly Ala Ser Thr Arg Ala Pro Gly Ile Pro Glu Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu 
 65                  70                  75                  80  
 
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Ala Ser Ser Arg 
                 85                  90                  95      
 
Thr Phe Gly Gln Gly Thr Arg 
            100              
 
<210>  12 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2C10 light chain variable domain 
 
<400>  12 
Gln Ser Val Val Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
  1               5                  10                  15      
 
Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Thr Ile Gly Thr Asn 
             20                  25                  30          
 
Tyr Val Ala Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
         35                  40                  45              
 
Ile Tyr Asp Asn Tyr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Trp Arg Ser Gly Thr Ser Ala Thr Leu Val Ile Ser Gly Leu Gln 
 65                  70                  75                  80  
 
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Arg Leu 
                 85                  90                  95      
 
Ser Val Gly Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  13 
<211>  103 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2C12 light chain variable domain 
 
<400>  13 
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
  1               5                  10                  15      
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ile Tyr 
             20                  25                  30          
 
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
         35                  40                  45              
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
     50                  55                  60                  
 
Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
 65                  70                  75                  80  
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Thr Pro Gln 
                 85                  90                  95      
 
Thr Phe Gly Gln Gly Thr Lys 
            100              
 
<210>  14 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2D3 light chain variable domain 
 
<400>  14 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Ile 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Val Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                 85                  90                  95      
 
Ser Asn Trp Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  15 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2G7 light chain variable domain 
 
<400>  15 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Ile Thr Ile Ser Cys Thr Arg Ser Gly Gly Thr Ile Gly Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                 85                  90                  95      
 
Ser Asn Arg Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  16 
<211>  103 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2H4 light chain variable domain 
 
<400>  16 
Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Val Ser Ala Ala Pro Gly 
  1               5                  10                  15      
 
Asp Lys Val Ser Ile Ser Cys Lys Ala Ser Glu Phe Ile Gly Asp Asp 
             20                  25                  30          
 
Val Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Val Phe Ile Ile 
         35                  40                  45              
 
Gln Glu Ala Arg Val Pro Val Arg Gly Ile Pro Pro Arg Phe Ser Gly 
     50                  55                  60                  
 
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asp Asp Ile Gln Ser 
 65                  70                  75                  80  
 
Glu Asp Ser Ala Phe Tyr Phe Cys Leu Gln Tyr Asp Ser Phe Pro Leu 
                 85                  90                  95      
 
Thr Phe Gly Gln Gly Thr Lys 
            100              
 
<210>  17 
<211>  107 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3A11 light chain variable domain 
 
<400>  17 
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
  1               5                  10                  15      
 
Ala Ile Thr Met Pro Cys Thr Gly Thr Ser Ser Asp Val Gly Thr Tyr 
             20                  25                  30          
 
Asn Tyr Val Ser Trp Tyr Gln His Phe Pro Gly Lys Ala Pro Lys Leu 
         35                  40                  45              
 
Leu Ile Tyr Asp Val Ser His Arg Pro Ala Gly Ile Ser Asp Arg Phe 
     50                  55                  60                  
 
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
 65                  70                  75                  80  
 
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Phe Ser Ser Ser 
                 85                  90                  95      
 
Ser Thr Leu Leu Val Phe Gly Gly Gly Thr Lys 
            100                 105          
 
<210>  18 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3C5 light chain variable domain 
 
<400>  18 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                 85                  90                  95      
 
Ser Asn Trp Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  19 
<211>  107 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3D2 light chain variable domain 
 
<400>  19 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Asn 
             20                  25                  30          
 
Tyr Val His Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg 
                 85                  90                  95      
 
Thr Asn Lys Arg Val Phe Gly Gly Gly Thr Arg 
            100                 105          
 
<210>  20 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3D11 light chain variable domain 
 
<400>  20 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Pro Cys Thr Gly Ser Ser Gly Asn Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn 
                 85                  90                  95      
 
Asn Ile Gln Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  21 
<211>  108 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3E9 light chain variable domain 
 
<400>  21 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                 85                  90                  95      
 
Ser Asn Leu Gln Trp Val Phe Gly Gly Gly Thr Lys 
            100                 105              
 
<210>  22 
<211>  106 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3F1 light chain variable domain 
 
<400>  22 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Ala Ser Gly Gly Ser Ile Ala Asp Asn 
             20                  25                  30          
 
Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Leu 
         35                  40                  45              
 
Ile Tyr Asp Tyr Ser Arg Arg Pro Tyr Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Val Ser Gly 
 65                  70                  75                  80  
 
Leu Met Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ile 
                 85                  90                  95      
 
Ser Asn Pro Val Phe Gly Gly Gly Thr Lys 
            100                 105      
 
<210>  23 
<211>  104 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3F11 light chain variable domain 
 
<400>  23 
Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
  1               5                  10                  15      
 
Glu Ser Ala Thr Leu Ser Cys Arg Ala Ser His Ser Asp Gly Arg Asn 
             20                  25                  30          
 
Tyr Ile Ala Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu 
         35                  40                  45              
 
Val Tyr Asp Thr Ser Asn Arg Ala Ala Gly Val Pro Asp Arg Phe Arg 
     50                  55                  60                  
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
 65                  70                  75                  80  
 
Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Phe Arg Arg Ser Val 
                 85                  90                  95      
 
Ser Thr Phe Gly Gln Gly Thr Lys 
            100                  
 
<210>  24 
<211>  108 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3H7 light chain variable domain 
 
<400>  24 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Arg Ser Thr Asp Ser Ile Ala Ser Asn 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                 85                  90                  95      
 
Val Asn Arg Gly Val Ile Phe Gly Gly Gly Thr Lys 
            100                 105              
 
<210>  25 
<211>  107 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3H11 light chain variable domain 
 
<400>  25 
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
  1               5                  10                  15      
 
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Asn Ile Ala Ser Tyr 
             20                  25                  30          
 
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
         35                  40                  45              
 
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
 65                  70                  75                  80  
 
Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg 
                 85                  90                  95      
 
Pro Asn His Val Val Phe Gly Gly Gly Thr Arg 
            100                 105          
 
<210>  26 
<211>  103 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  5A6 light chain variable domain 
 
<400>  26 
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
  1               5                  10                  15      
 
His Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
             20                  25                  30          
 
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
         35                  40                  45              
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
     50                  55                  60                  
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
 65                  70                  75                  80  
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Leu Pro Arg 
                 85                  90                  95      
 
Thr Phe Gly Gly Gly Thr Lys 
            100              
 
<210>  27 
<211>  104 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  6F8 light chain variable domain 
 
<400>  27 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
  1               5                  10                  15      
 
Glu Arg Ala Thr Leu Ser Cys Thr Ala Ser Gln Thr Ile Asn Asn Asn 
             20                  25                  30          
 
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Gly Pro Ser Leu Leu 
         35                  40                  45              
 
Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
     50                  55                  60                  
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
 65                  70                  75                  80  
 
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                 85                  90                  95      
 
Arg Thr Phe Gly Gln Gly Thr Lys 
            100                  
 
<210>  28 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  28 
Ser Gly Ser Ile Ala Ser His Tyr 
  1               5              
 
<210>  29 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  29 
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr 
  1               5                  10          
 
<210>  30 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  30 
Gly Gly Arg Ile Ala Thr Asn Tyr 
  1               5              
 
<210>  31 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  31 
Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr 
  1               5                  10      
 
<210>  32 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  32 
Gln Ser Leu Leu His Ser Asn Gly Phe Thr Tyr 
  1               5                  10      
 
<210>  33 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  33 
Ser Gly Ser Ile Ala Ser Tyr Tyr 
  1               5              
 
<210>  34 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  34 
Ser Gly Ser Ile Ala Ser Asn Tyr 
  1               5              
 
<210>  35 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  35 
Ser Gly Arg Ile Ala Ser Asn Tyr 
  1               5              
 
<210>  36 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  36 
Ser Ser Asn Ile Gly Arg Asn Phe 
  1               5              
 
<210>  37 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  37 
Gln Thr Val Gly Gly Ser Tyr 
  1               5          
 
<210>  38 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  38 
Ser Ser Thr Ile Gly Thr Asn Tyr 
  1               5              
 
<210>  39 
<211>  6 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  39 
Gln Ser Ile Asn Ile Tyr 
  1               5      
 
<210>  40 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  40 
Gly Gly Thr Ile Gly Ser Asn Tyr 
  1               5              
 
<210>  41 
<211>  6 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  41 
Glu Phe Ile Gly Asp Asp 
  1               5      
 
<210>  42 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  42 
Ser Ser Asp Val Gly Thr Tyr Asn Tyr 
  1               5                  
 
<210>  43 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  43 
Ser Gly Ser Ile Ala Arg Asn Tyr 
  1               5              
 
<210>  44 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  44 
Ser Gly Asn Ile Ala Ser Asn Tyr 
  1               5              
 
<210>  45 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  45 
Gly Gly Ser Ile Ala Asp Asn Phe 
  1               5              
 
<210>  46 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  46 
His Ser Asp Gly Arg Asn Tyr 
  1               5          
 
<210>  47 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  47 
Thr Asp Ser Ile Ala Ser Asn Tyr 
  1               5              
 
<210>  48 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  48 
Ser Gly Asn Ile Ala Ser Tyr Tyr 
  1               5              
 
<210>  49 
<211>  6 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  49 
Gln Ser Ile Ser Ser Tyr 
  1               5      
 
<210>  50 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  50 
Gln Thr Ile Asn Asn Asn Tyr 
  1               5          
 
<210>  51 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  51 
Glu Asp Asn 
  1          
 
<210>  52 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  52 
Trp Ala Ser 
  1          
 
<210>  53 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  53 
Leu Gly Ser 
  1          
 
<210>  54 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  54 
Glu Asp Asp 
  1          
 
<210>  55 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  55 
Glu Asp Thr 
  1          
 
<210>  56 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  56 
Arg Asn Asn 
  1          
 
<210>  57 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  57 
Gly Ala Ser 
  1          
 
<210>  58 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  58 
Asp Asn Tyr 
  1          
 
<210>  59 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  59 
Ala Ala Ser 
  1          
 
<210>  60 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  60 
Glu Ala Arg 
  1          
 
<210>  61 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  61 
Asp Val Ser 
  1          
 
<210>  62 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  62 
Asp Tyr Ser 
  1          
 
<210>  63 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  63 
Asp Thr Ser 
  1          
 
<210>  64 
<211>  3 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  64 
Asp Ala Ser 
  1          
 
<210>  65 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  65 
Gln Ser Tyr Gly Ser Gly Phe Val Val 
  1               5                  
 
<210>  66 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  66 
Gln Gln Tyr Tyr Gly Thr Pro Tyr Thr 
  1               5                  
 
<210>  67 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  67 
Gln Ser His Asp Thr Ser Arg Gln Ala Val 
  1               5                  10  
 
<210>  68 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  68 
Met Gln Ala Leu Gln Thr Pro Tyr Thr 
  1               5                  
 
<210>  69 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  69 
Met Gln Gly Ile Gln Thr Pro Leu Thr 
  1               5                  
 
<210>  70 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  70 
Gln Ser Phe Asp Ser Ser Ile Gln His Val Val 
  1               5                  10      
 
<210>  71 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  71 
Gln Ser Tyr Asp Gly Ser Ala Trp Val 
  1               5                  
 
<210>  72 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  72 
Gln Ser Phe Asp Ser Gly Asn Gln Arg Val Val 
  1               5                  10      
 
<210>  73 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  73 
Gln Ser Tyr Asp Asn Ser Leu Phe Val Val 
  1               5                  10  
 
<210>  74 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  74 
Gln Ser Tyr Asp Glu Asn Ile Arg Val 
  1               5                  
 
<210>  75 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  75 
Gln Gln Tyr Ala Ser Ser Arg Thr 
  1               5              
 
<210>  76 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  76 
Gly Thr Trp Asp Ser Arg Leu Ser Val Gly Val 
  1               5                  10      
 
<210>  77 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  77 
Gln Gln Ser Tyr Ile Thr Pro Gln Thr 
  1               5                  
 
<210>  78 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  78 
Gln Ser Tyr Asp Ser Ser Asn Trp Val 
  1               5                  
 
<210>  79 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  79 
Gln Ser Tyr Asp Ser Ser Asn Arg Val 
  1               5                  
 
<210>  80 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  80 
Leu Gln Tyr Asp Ser Phe Pro Leu Thr 
  1               5                  
 
<210>  81 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  81 
Ala Ser Phe Ser Ser Ser Ser Thr Leu Leu Val 
  1               5                  10      
 
<210>  82 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  82 
Gln Ser Tyr Asp Arg Thr Asn Lys Arg Val 
  1               5                  10  
 
<210>  83 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  83 
Gln Ser Tyr Asp Asn Asn Ile Gln Val 
  1               5                  
 
<210>  84 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  84 
Gln Ser Tyr Asp Ser Ser Asn Leu Gln Trp Val 
  1               5                  10      
 
<210>  85 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  85 
Gln Ser Tyr Asp Ile Ser Asn Pro Val 
  1               5                  
 
<210>  86 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  86 
His Gln Phe Arg Arg Ser Val Ser Thr 
  1               5                  
 
<210>  87 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  87 
Gln Ser Tyr Asp Gly Val Asn Arg Gly Val Ile 
  1               5                  10      
 
<210>  88 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  88 
Gln Ser Tyr Asp Arg Pro Asn His Val Val 
  1               5                  10  
 
<210>  89 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  89 
Gln Gln Ser Tyr Asn Leu Pro Arg Thr 
  1               5                  
 
<210>  90 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  90 
Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
  1               5                  
 
<210>  91 
<211>  110 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1A5 heavy chain variable domain 
 
<400>  91 
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
  1               5                  10                  15      
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
         35                  40                  45              
 
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
     50                  55                  60                  
 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
 65                  70                  75                  80  
 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Lys Asp Tyr Phe Arg Trp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110  
 
<210>  92 
<211>  115 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1A8 heavy chain variable domain 
 
<400>  92 
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
  1               5                  10                  15      
 
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Ser Ser Arg 
             20                  25                  30          
 
Ser Asp His Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
         35                  40                  45              
 
Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
     50                  55                  60                  
 
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu 
 65                  70                  75                  80  
 
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                 85                  90                  95      
 
Cys Ala Arg Leu Ala Ser Leu Tyr Ser Thr Phe Asp Ile Trp Gly His 
            100                 105                 110          
 
Gly Thr Leu 
        115  
 
<210>  93 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1B2 heavy chain variable domain 
 
<400>  93 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
             20                  25                  30          
 
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Thr Gly Glu Met Ala Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Leu 
     
 
<210>  94 
<211>  120 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1B11 heavy chain variable domain 
 
<400>  94 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Asp Asn Pro Gly Tyr Ser Ser Ser Trp Ser Pro Asn Trp Phe 
            100                 105                 110          
 
Asp Pro Trp Gly Gln Gly Thr Leu 
        115                 120  
 
<210>  95 
<211>  114 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1C2 heavy chain variable domain 
 
<400>  95 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
             20                  25                  30          
 
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Ser Ser Ser Ala Gly Thr Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110          
 
Thr Leu 
         
 
<210>  96 
<211>  116 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1C3 heavy chain variable domain 
 
<400>  96 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Ser Thr Tyr 
             20                  25                  30          
 
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Phe Tyr Cys 
                 85                  90                  95      
 
Ala Arg Val Ala Glu Gln His Leu Asp Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110          
 
Gln Gly Thr Leu 
        115      
 
<210>  97 
<211>  114 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1D12 heavy chain variable domain 
 
<400>  97 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Leu Glu Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110          
 
Thr Thr 
         
 
<210>  98 
<211>  118 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1E5 heavy chain variable domain 
 
<400>  98 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Ala Leu Val Gly Lys Trp Leu Leu Leu Arg Gly Phe Asp Tyr 
            100                 105                 110          
 
Trp Gly Gln Gly Thr Leu 
        115              
 
<210>  99 
<211>  118 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1F4 heavy chain variable domain 
 
<400>  99 
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
  1               5                  10                  15      
 
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
             20                  25                  30          
 
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
         35                  40                  45              
 
Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
     50                  55                  60                  
 
Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
 65                  70                  75                  80  
 
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                 85                  90                  95      
 
Tyr Tyr Cys Ala Arg Glu Lys Gly Ile Glu Gly Pro Ala Phe Asp Pro 
            100                 105                 110          
 
Trp Gly Gln Gly Thr Leu 
        115              
 
<210>  100 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  1H7 heavy chain variable domain 
 
<400>  100 
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
  1               5                  10                  15      
 
Thr Leu Pro Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
             20                  25                  30          
 
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
         35                  40                  45              
 
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
     50                  55                  60                  
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
 65                  70                  75                  80  
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95      
 
Arg Gly Arg Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Met 
     
 
<210>  101 
<211>  119 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2C9 heavy chain variable domain 
 
<400>  101 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg His Gly Gly Val Gly Ala Thr Thr Gly Tyr Tyr Tyr Met Asp 
            100                 105                 110          
 
Val Trp Gly Lys Gly Thr Thr 
        115                  
 
<210>  102 
<211>  112 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2C10 heavy chain variable domain 
 
<400>  102 
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
  1               5                  10                  15      
 
Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
             20                  25                  30          
 
Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
         35                  40                  45              
 
Gly Glu Ile Asn Tyr Arg Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
     50                  55                  60                  
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
 65                  70                  75                  80  
 
Asn Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95      
 
Arg Trp Asp Gly Gly Asn Ser Val Asp His Trp Gly Gln Gly Thr Leu 
            100                 105                 110          
 
<210>  103 
<211>  117 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2C12 heavy chain variable domain 
 
<400>  103 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
  1               5                  10                  15      
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
         35                  40                  45              
 
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
     50                  55                  60                  
 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
 65                  70                  75                  80  
 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Gly Gly Arg Phe His Tyr Tyr Tyr Tyr Ala Met Asp Val Trp 
            100                 105                 110          
 
Gly Gln Gly Thr Thr 
        115          
 
<210>  104 
<211>  114 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2D3 heavy chain variable domain 
 
<400>  104 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Ser Ser Gly Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110          
 
Thr Met 
         
 
<210>  105 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2G7 heavy chain variable domain 
 
<400>  105 
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
  1               5                  10                  15      
 
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
             20                  25                  30          
 
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
         35                  40                  45              
 
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
     50                  55                  60                  
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
 65                  70                  75                  80  
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95      
 
Arg Gly Lys Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Met 
     
 
<210>  106 
<211>  118 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  2H4 heavy chain variable domain 
 
<400>  106 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Thr Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Gly Tyr 
             20                  25                  30          
 
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Arg Val Asn Pro Asn Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Asp Arg Val Thr Leu Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Phe Cys 
                 85                  90                  95      
 
Ala Arg Gly Gly Arg Pro Gly Leu Pro Ala Ala Gly Tyr Ile Asp Tyr 
            100                 105                 110          
 
Trp Gly Gln Gly Thr Leu 
        115              
 
<210>  107 
<211>  116 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3A11 heavy chain variable domain 
 
<400>  107 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Thr Tyr 
             20                  25                  30          
 
Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Trp Ile Ser Thr Tyr Asn Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ile Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Gly Asp Ser Ser Val Gly Tyr Glu Tyr Phe Gln His Trp Gly 
            100                 105                 110          
 
Gln Gly Thr Leu 
        115      
 
<210>  108 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3C5 heavy chain variable domain 
 
<400>  108 
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
  1               5                  10                  15      
 
Thr Leu Ser Leu Thr Cys Gly Val Tyr Gly Gly Ser Leu Ser Gly Tyr 
             20                  25                  30          
 
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
         35                  40                  45              
 
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
     50                  55                  60                  
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
 65                  70                  75                  80  
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95      
 
Arg Arg Trp Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Thr 
     
 
<210>  109 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3D2,3D11 heavy chain variable domain 
 
<400>  109 
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
  1               5                  10                  15      
 
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
             20                  25                  30          
 
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
         35                  40                  45              
 
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
     50                  55                  60                  
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
 65                  70                  75                  80  
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95      
 
Arg Arg Trp Trp Leu Arg Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Thr 
     
 
<210>  110 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3E9 heavy chain variable domain 
 
<400>  110 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
             20                  25                  30          
 
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Gly Ile Ile Thr Met Ile Ser Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Leu 
     
 
<210>  111 
<211>  112 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3F1 heavy chain variable domain 
 
<400>  111 
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
  1               5                  10                  15      
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
         35                  40                  45              
 
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
     50                  55                  60                  
 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
 65                  70                  75                  80  
 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Asp Gly Gly Gly Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110          
 
<210>  112 
<211>  113 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3F11 heavy chain variable domain 
 
<400>  112 
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Ser 
             20                  25                  30          
 
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Arg Gly Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Thr Ser Ile Ala Val Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110          
 
Leu 
     
 
<210>  113 
<211>  116 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3H7 heavy chain variable domain 
 
<400>  113 
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
  1               5                  10                  15      
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
             20                  25                  30          
 
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
         35                  40                  45              
 
Ala Val Ile Trp His Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
     50                  55                  60                  
 
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
 65                  70                  75                  80  
 
Leu Gln Met Asp Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Val Arg Asp Gln Gly Ala Gly Val Trp Asn Gly Tyr Ser Tyr Trp Gly 
            100                 105                 110          
 
Gln Gly Thr Leu 
        115      
 
<210>  114 
<211>  120 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  3H11 heavy chain variable domain 
 
<400>  114 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
  1               5                  10                  15      
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
             20                  25                  30          
 
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
         35                  40                  45              
 
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
     50                  55                  60                  
 
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr 
 65                  70                  75                  80  
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Ser Ser Val Val Pro Ala Ala Ile Tyr Asp Tyr Tyr Tyr Gly Met 
            100                 105                 110          
 
Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120  
 
<210>  115 
<211>  114 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  5A6 heavy chain variable domain 
 
<400>  115 
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
  1               5                  10                  15      
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
             20                  25                  30          
 
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
         35                  40                  45              
 
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
     50                  55                  60                  
 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
 65                  70                  75                  80  
 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                 85                  90                  95      
 
Ala Arg Leu Ile Thr Met Val Arg Gly Glu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110          
 
Thr Leu 
         
 
<210>  116 
<211>  112 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  6F8 heavy chain variable domain 
 
<400>  116 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
  1               5                  10                  15      
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
             20                  25                  30          
 
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
         35                  40                  45              
 
Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
     50                  55                  60                  
 
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
 65                  70                  75                  80  
 
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                 85                  90                  95      
 
Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110          
 
<210>  117 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  117 
Gly Phe Thr Phe Ser Ser Tyr Ala 
  1               5              
 
<210>  118 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  118 
Gly Val Ser Ile Ser Ser Arg Ser Asp His 
  1               5                  10  
 
<210>  119 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  119 
Gly Tyr Thr Phe Thr Ser Tyr Tyr 
  1               5              
 
<210>  120 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  120 
Gly Gly Thr Phe Ser Ser Tyr Ala 
  1               5              
 
<210>  121 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  121 
Gly Tyr Pro Phe Ser Thr Tyr Tyr 
  1               5              
 
<210>  122 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  122 
Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
  1               5                  10  
 
<210>  123 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  123 
Gly Gly Ser Phe Ser Gly Tyr Tyr 
  1               5              
 
<210>  124 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  124 
Gly Tyr Thr Phe Ser Gly Tyr Tyr 
  1               5              
 
<210>  125 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  125 
Gly Tyr Thr Phe Ser Thr Tyr Asp 
  1               5              
 
<210>  126 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  126 
Gly Gly Ser Leu Ser Gly Tyr Tyr 
  1               5              
 
<210>  127 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  127 
Gly Tyr Thr Phe Thr Ser Tyr Gly 
  1               5              
 
<210>  128 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  128 
Gly Phe Thr Phe Ser Ser Tyr Gly 
  1               5              
 
<210>  129 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  129 
Gly Tyr Thr Phe Ser Ser Ser Gly 
  1               5              
 
<210>  130 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  130 
Gly Phe Thr Phe Ser Asn Tyr Gly 
  1               5              
 
<210>  131 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  131 
Gly Phe Thr Phe Ser Ser Tyr Glu 
  1               5              
 
<210>  132 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  132 
Gly Phe Thr Val Ser Ser Asn Tyr 
  1               5              
 
<210>  133 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  133 
Ile Ser Gly Ser Gly Gly Ser Thr 
  1               5              
 
<210>  134 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  134 
Ile Ser Tyr Ser Gly Ser Thr 
  1               5          
 
<210>  135 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  135 
Ile Asn Pro Ser Gly Gly Ser Thr 
  1               5              
 
<210>  136 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  136 
Ile Ile Pro Ile Phe Gly Thr Ala 
  1               5              
 
<210>  137 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  137 
Ile Asp Pro Ser Gly Gly Ser Thr 
  1               5              
 
<210>  138 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  138 
Ile Ser Ala Tyr Asn Gly Asn Thr 
  1               5              
 
<210>  139 
<211>  9 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  139 
Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
  1               5                  
 
<210>  140 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  140 
Ile Asn His Ser Gly Ser Thr 
  1               5          
 
<210>  141 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  141 
Ile Ile Pro Ile Leu Gly Ile Ala 
  1               5              
 
<210>  142 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  142 
Ile Asn Tyr Arg Gly Asn Thr 
  1               5          
 
<210>  143 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  143 
Ile Ser Tyr Asp Gly Ser Asn Lys 
  1               5              
 
<210>  144 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  144 
Val Asn Pro Asn Ser Gly Gly Thr 
  1               5              
 
<210>  145 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  145 
Ile Ser Thr Tyr Asn Gly Asp Thr 
  1               5              
 
<210>  146 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  146 
Ile Ser Thr Tyr Asn Gly Asn Thr 
  1               5              
 
<210>  147 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  147 
Ile Trp His Asp Gly Thr Asn Lys 
  1               5              
 
<210>  148 
<211>  7 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  148 
Ile Tyr Ser Gly Gly Ser Thr 
  1               5          
 
<210>  149 
<211>  8 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  149 
Ala Lys Asp Tyr Phe Arg Trp Leu 
  1               5              
 
<210>  150 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  150 
Ala Arg Leu Ala Ser Leu Tyr Ser Thr Phe Asp Ile 
  1               5                  10          
 
<210>  151 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  151 
Ala Thr Gly Glu Met Ala Gly Asp Phe Asp Tyr 
  1               5                  10      
 
<210>  152 
<211>  18 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  152 
Ala Arg Asp Asn Pro Gly Tyr Ser Ser Ser Trp Ser Pro Asn Trp Phe 
  1               5                  10                  15      
 
Asp Pro 
         
 
<210>  153 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  153 
Ala Ser Ser Ser Ala Gly Thr Phe Tyr Phe Asp Tyr 
  1               5                  10          
 
<210>  154 
<211>  14 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  154 
Ala Arg Val Ala Glu Gln His Leu Asp Tyr Tyr Phe Asp Tyr 
  1               5                  10                  
 
<210>  155 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  155 
Ala Arg Leu Glu Trp Leu Arg Gly Ala Phe Asp Ile 
  1               5                  10          
 
<210>  156 
<211>  16 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  156 
Ala Arg Ala Leu Val Gly Lys Trp Leu Leu Leu Arg Gly Phe Asp Tyr 
  1               5                  10                  15      
 
<210>  157 
<211>  13 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  157 
Ala Arg Glu Lys Gly Ile Glu Gly Pro Ala Phe Asp Pro 
  1               5                  10              
 
<210>  158 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  158 
Ala Arg Gly Arg Trp Leu Arg Gly Ala Phe Asp Ile 
  1               5                  10          
 
<210>  159 
<211>  17 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  159 
Ala Arg His Gly Gly Val Gly Ala Thr Thr Gly Tyr Tyr Tyr Met Asp 
  1               5                  10                  15      
 
Val 
     
 
<210>  160 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  160 
Ala Arg Trp Asp Gly Gly Asn Ser Val Asp His 
  1               5                  10      
 
<210>  161 
<211>  15 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  161 
Ala Arg Gly Gly Arg Phe His Tyr Tyr Tyr Tyr Ala Met Asp Val 
  1               5                  10                  15  
 
<210>  162 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  162 
Ala Ser Ser Gly Trp Leu Arg Gly Ala Phe Asp Ile 
  1               5                  10          
 
<210>  163 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  163 
Ala Arg Gly Lys Trp Leu Arg Gly Ala Phe Asp Ile 
  1               5                  10          
 
<210>  164 
<211>  16 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  164 
Ala Arg Gly Gly Arg Pro Gly Leu Pro Ala Ala Gly Tyr Ile Asp Tyr 
  1               5                  10                  15      
 
<210>  165 
<211>  14 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  165 
Ala Arg Gly Asp Ser Ser Val Gly Tyr Glu Tyr Phe Gln His 
  1               5                  10                  
 
<210>  166 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  166 
Ala Arg Arg Trp Trp Leu Arg Gly Ala Phe Asp Ile 
  1               5                  10          
 
<210>  167 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  167 
Ala Arg Gly Ile Ile Thr Met Ile Ser Asp Tyr 
  1               5                  10      
 
<210>  168 
<211>  10 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  168 
Ala Arg Asp Gly Gly Gly Gly Met Asp Val 
  1               5                  10  
 
<210>  169 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  169 
Ala Thr Ser Ile Ala Val Ala Gly Ile Asp Tyr 
  1               5                  10      
 
<210>  170 
<211>  14 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  170 
Val Arg Asp Gln Gly Ala Gly Val Trp Asn Gly Tyr Ser Tyr 
  1               5                  10                  
 
<210>  171 
<211>  18 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  171 
Ala Ser Ser Val Val Pro Ala Ala Ile Tyr Asp Tyr Tyr Tyr Gly Met 
  1               5                  10                  15      
 
Asp Val 
         
 
<210>  172 
<211>  12 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  172 
Ala Arg Leu Ile Thr Met Val Arg Gly Glu Asp Tyr 
  1               5                  10          
 
<210>  173 
<211>  11 
<212>  PRT 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  173 
Ala Arg Asp Tyr Gly Asp Tyr Tyr Phe Asp Tyr 
  1               5                  10      
 
<210>  174 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1A5 light chain variable domain 
 
<400>  174 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtagccatc       60 
 
tcctgcaccg gcaacagtgg cagcattgcc agccactatg tgcagtggtt ccaacagcgc      120 
 
ccgggcagtg cccccactac tgtgatctat gaagataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacaggtcg tccaactctg cctccctcac catctctgga      240 
 
cttaagagtg aggacgaggc tgactattac tgtcagtctt atggcagcgg ctttgtggtc      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  175 
<211>  327 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1A8 light chain variable domain 
 
<400>  175 
gaaattgtgt tgacgcagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60 
 
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120 
 
tggtatcaac agaaaccagg acagcctcct aagttgctca tttactgggc ttctacccgg      180 
 
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240 
 
atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatggtact      300 
 
ccgtacactt ttggccaggg gaccaag                                          327 
 
 
<210>  176 
<211>  321 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1B2 light chain variable domain 
 
<400>  176 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac cgtaaccatc       60 
 
tcctgcaccg gcagcggtgg caggattgcc accaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataata aaagaccctc tggggtccct      180 
 
catcggttct ctggctccat cgacgcctcc tccaattctg cctccctcac tatctctgga      240 
 
ctggagactg aggacgaggc tgactactac tgtcagtctc atgataccag ccgtcaggcg      300 
 
gttttcggcg gcgggaccaa g                                                321 
 
 
<210>  177 
<211>  324 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1B11 light chain variable domain 
 
<400>  177 
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60 
 
atctcctgca ggtctagtca gagcctcctg tatagtaatg gatacaacta tttggattgg      120 
 
tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180 
 
tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240 
 
agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaaccccg      300 
 
tacacttttg gccaggggac caag                                             324 
 
 
<210>  178 
<211>  324 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1C2 light chain variable domain 
 
<400>  178 
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60 
 
atctcctgca ggtctagtca gagcctcctg catagtaatg gattcaccta tttggattgg      120 
 
tacctgcaga agccagggct gtctccacag ctcctgatct acttgggttc taatcgggcc      180 
 
cccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240 
 
agcagagtgg aggctgagga tgttggggtt tattactgca tgcaaggtat acaaaccccc      300 
 
ctcactttcg gcggggggac caag                                             324 
 
 
<210>  179 
<211>  324 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1C3 light chain variable domain 
 
<400>  179 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccc gcagcagcgg cagcattgcc agctactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtt cccccaccac tgtgatctat gaagatgacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagtgcc tccaactcag cctccctcac catctctggc      240 
 
ctgcagactg aggacgaggc tgactactac tgtcagtctt ttgatagcag cattcaacat      300 
 
gtggtcttcg gcggagggac ccag                                             324 
 
 
<210>  180 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1D12 light chain variable domain 
 
<400>  180 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccg gcagcagtgg cagcattgcc agcaattatg tgcattggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct caggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatggcag cgcttgggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  181 
<211>  324 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1E5 light chain variable domain 
 
<400>  181 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac gttaaccatc       60 
 
tcctgcaccc gcagcagtgg caggattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataccc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt ttgatagcgg caatcaacgg      300 
 
gtggttttcg gcggagggac caaa                                             324 
 
 
<210>  182 
<211>  315 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1F4 light chain variable domain 
 
<400>  182 
cagtctgtgt tgacgcagcc gccctcagtg tctgggaccc ccgggcagag ggtcaccatc       60 
 
tcttgctctg gaagcagctc caacatcgga cgtaattttg tatcctggta ccagcagctc      120 
 
ccaggagcgg cccccagact cctcatgtat aggaataatc agcggccctc aggggtccct      180 
 
gaccgattct ctggctccga gtctgccacc tcagcctccc tggccatcac tgggctccag      240 
 
cctgaggatg aagctgatta ttactgccag tcctatgaca acagcctgtt tgtggtattc      300 
 
ggcggaggga ccaag                                                       315 
 
 
<210>  183 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1H7 light chain variable domain 
 
<400>  183 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccc gcagcagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccgt cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatgaaaa cattcgggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  184 
<211>  309 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2C9 light chain variable domain 
 
<400>  184 
gaaattgtgt tgacgcagtc tccaggcacc ctgtcttcgt ctcctgggga gagagccacc       60 
 
ctctcctgca cggccagcca gactgtcggc ggcagctact tagcctggta ccagcaaaaa      120 
 
cgtggccagc ctcccaggct cctcatctat ggtgcgtcca ctagggcccc tggcatccca      180 
 
gagagattta gtggcagtgg gtctgggaca gacttcactc tcaccatcag caccctggag      240 
 
cctgaagatt ttgcagtgta tttctgtcag cagtatgcca gttcacggac gttcggccaa      300 
 
gggaccagg                                                              309 
 
 
<210>  185 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2C10 light chain variable domain 
 
<400>  185 
cagtctgtcg tgacgcagcc gccctccgcg tccgggtctc ctggacagtc agtcaccatc       60 
 
tcctgttctg gaagcagctc caccattgga actaattatg tggcctggta ccagcagctc      120 
 
ccaggaacag cccccaaact cctcatttat gacaattata agcgaccctc gggaattcct      180 
 
gaccgattct ctggctggag gtctggcacg tcagccaccc tggtcatcag cggactccag      240 
 
accggggacg aggccgatta ttactgcgga acgtgggata gtaggctgag tgttggcgtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  186 
<211>  309 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2C12 light chain variable domain 
 
<400>  186 
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gagcattaac atctatttaa attggtatca gcagaaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180 
 
aggttcagtg gcagtggatc tgcgacagat ttcactctca ccatcagcag tctgcagcct      240 
 
gaagattttg caacttacta ctgtcaacag agttacatta cccctcagac gttcggccaa      300 
 
gggaccaag                                                              309 
 
 
<210>  187 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2D3 light chain variable domain 
 
<400>  187 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccg gcagcagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tattatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccgt cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag caattgggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  188 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2G7 light chain variable domain 
 
<400>  188 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac gataaccatc       60 
 
tcctgcaccc gcagcggtgg caccattggc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag caatcgggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  189 
<211>  309 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2H4 light chain variable domain 
 
<400>  189 
gaaacgacac tcacgcagtc tccagcattc gtgtcggcgg ctcccggaga caaagtgtcc       60 
 
atctcctgca aagccagtga attcattgga gatgatgtga actggtacca acagaaacca      120 
 
ggagaggctc ctgttttcat cattcaagag gctcgtgttc ccgttcgtgg aatcccaccc      180 
 
cgattcagtg gcagcggcta tggaacagat tttaccctca caattgatga catacaatct      240 
 
gaggattctg cattttactt ctgtctgcaa tatgattctt tccctctcac ttttggccag      300 
 
gggaccaag                                                              309 
 
 
<210>  190 
<211>  321 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3A11 light chain variable domain 
 
<400>  190 
caatctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacaggc gatcaccatg       60 
 
ccctgcactg gaaccagcag tgacgttggt acttataact atgtctcctg gtatcaacac      120 
 
ttcccaggca aagcccccaa actcttgatt tatgatgtca gtcatcggcc cgcggggatt      180 
 
tctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctggcctc      240 
 
caggctgagg acgaagctga ctattactgc gcttcatttt catccagcag cactctctta      300 
 
gtgttcggcg gagggaccaa g                                                321 
 
 
<210>  191 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3C5 light chain variable domain 
 
<400>  191 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccg gcagcagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag caattgggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  192 
<211>  321 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3D2 light chain variable domain 
 
<400>  192 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccg gcagcagtgg cagcattgcc cgcaactatg tgcattggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgataggac caataagagg      300 
 
gttttcggcg gagggaccag g                                                321 
 
 
<210>  193 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3D11 light chain variable domain 
 
<400>  193 
aattttatgc tgactcagcc ccactctgtg tcggcgtctc cggggaagac ggtaaccatc       60 
 
ccctgcaccg gcagcagtgg caacattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgataataa cattcaggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  194 
<211>  324 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3E9 light chain variable domain 
 
<400>  194 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccg gcagcagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag caaccttcag      300 
 
tgggtgttcg gcggagggac caag                                             324 
 
 
<210>  195 
<211>  318 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3F1 light chain variable domain 
 
<400>  195 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtcaccatc       60 
 
tcctgcaccg ccagcggtgg cagcattgcc gacaactttg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tctgatctat gactatagtc gaagacccta tggggtccca      180 
 
gatcggttct ctggctccat cgacaggtcc tccaattctg cctccctcac cgtctctgga      240 
 
ctgatgactg aggacgaggc tgactactat tgtcagtctt atgatatcag caatccggtg      300 
 
ttcggcggag ggaccaag                                                    318 
 
 
<210>  196 
<211>  312 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3F11 light chain variable domain 
 
<400>  196 
gaaacgacac tcacgcagtc tccaggcacc ctgtccttgt ctccagggga aagcgccacc       60 
 
ctctcctgca gggccagtca cagtgatggc aggaattaca ttgcctggta ccagcagaca      120 
 
cctggccagg ctcccaggct cctcgtttat gatacgtcga acagggccgc tggcgtccca      180 
 
gacaggttca gaggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240 
 
cctgaggatt ttgcagttta tttctgtcat caatttcgga ggtccgtgtc cacttttggc      300 
 
caggggacca aa                                                          312 
 
 
<210>  197 
<211>  324 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3H7 light chain variable domain 
 
<400>  197 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccc gcagcactga cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtg cccccaccac tgtgatctat gaagataacc aaagaccctc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactcag cctccctcac catctctgga      240 
 
ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatggcgt caatcgcggc      300 
 
gtgatattcg gcggagggac caag                                             324 
 
 
<210>  198 
<211>  321 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3H11 light chain variable domain 
 
<400>  198 
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60 
 
tcctgcaccc gcagcagtgg caacattgcc agttactatg tgcagtggta ccagcagcgc      120 
 
ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccttc tggggtccct      180 
 
gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240 
 
ctgcagactg aggacgaggc tgactactac tgtcagtctt atgatcgtcc caatcatgtg      300 
 
gtgttcggcg gcgggaccag g                                                321 
 
 
<210>  199 
<211>  309 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  5A6 light chain variable domain 
 
<400>  199 
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtgggaca cagagtcacc       60 
 
atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120 
 
gggaaagccc ctaagctcct gatttatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg cgacttacta ctgtcaacag agttacaatc ttccgcgcac tttcggcgga      300 
 
gggaccaag                                                              309 
 
 
<210>  200 
<211>  312 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  6F8 light chain variable domain 
 
<400>  200 
gaaattgtgc tgactcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca cggccagtca gactattaac aacaactact tagcctggta ccagcagaaa      120 
 
cctggccagg gtcccagcct cctcatctat gatgcatcca gcagggccac tggcgtccca      180 
 
gacaggttca gtggcagtgg gtcggggaca gacttcactc tcaccatcag cagactggag      240 
 
cctgaagatt ttgcagtgta ttactgtcag cagtatggaa gctcgcctcg gacgttcggc      300 
 
caagggacca ag                                                          312 
 
 
<210>  201 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  201 
agtggcagca ttgccagcca ctat                                              24 
 
 
<210>  202 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  202 
cagagtgttt tatacagctc caacaataag aactac                                 36 
 
 
<210>  203 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  203 
ggtggcagga ttgccaccaa ctat                                              24 
 
 
<210>  204 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  204 
cagagcctcc tgtatagtaa tggatacaac tat                                    33 
 
 
<210>  205 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  205 
cagagcctcc tgcatagtaa tggattcacc tat                                    33 
 
 
<210>  206 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  206 
agcggcagca ttgccagcta ctat                                              24 
 
 
<210>  207 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  207 
agtggcagca ttgccagcaa ttat                                              24 
 
 
<210>  208 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  208 
agtggcagga ttgccagcaa ctat                                              24 
 
 
<210>  209 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  209 
agctccaaca tcggacgtaa tttt                                              24 
 
 
<210>  210 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  210 
agtggcagca ttgccagcaa ctat                                              24 
 
 
<210>  211 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  211 
cagactgtcg gcggcagcta c                                                 21 
 
 
<210>  212 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  212 
agctccacca ttggaactaa ttat                                              24 
 
 
<210>  213 
<211>  18 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  213 
cagagcatta acatctat                                                     18 
 
 
<210>  214 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  214 
ggtggcacca ttggcagcaa ctat                                              24 
 
 
<210>  215 
<211>  18 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  215 
gaattcattg gagatgat                                                     18 
 
 
<210>  216 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  216 
agcagtgacg ttggtactta taactat                                           27 
 
 
<210>  217 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  217 
agtggcagca ttgcccgcaa ctat                                              24 
 
 
<210>  218 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  218 
agtggcaaca ttgccagcaa ctat                                              24 
 
 
<210>  219 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  219 
ggtggcagca ttgccgacaa cttt                                              24 
 
 
<210>  220 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  220 
cacagtgatg gcaggaatta c                                                 21 
 
 
<210>  221 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  221 
actgacagca ttgccagcaa ctat                                              24 
 
 
<210>  222 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  222 
agtggcaaca ttgccagtta ctat                                              24 
 
 
<210>  223 
<211>  18 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  223 
cagagcatta gcagctat                                                     18 
 
 
<210>  224 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR1 
 
<400>  224 
cagactatta acaacaacta c                                                 21 
 
 
<210>  225 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  225 
gaagataac                                                                9 
 
 
<210>  226 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  226 
tgggcttct                                                                9 
 
 
<210>  227 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  227 
gaggataat                                                                9 
 
 
<210>  228 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  228 
ttgggttct                                                                9 
 
 
<210>  229 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  229 
gaagatgac                                                                9 
 
 
<210>  230 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  230 
gaggataac                                                                9 
 
 
<210>  231 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  231 
gaggatacc                                                                9 
 
 
<210>  232 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  232 
aggaataat                                                                9 
 
 
<210>  233 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  233 
ggtgcgtcc                                                                9 
 
 
<210>  234 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  234 
gacaattat                                                                9 
 
 
<210>  235 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  235 
gctgcatcc                                                                9 
 
 
<210>  236 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  236 
gaggctcgt                                                                9 
 
 
<210>  237 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  237 
gatgtcagt                                                                9 
 
 
<210>  238 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  238 
gactatagt                                                                9 
 
 
<210>  239 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  239 
gatacgtcg                                                                9 
 
 
<210>  240 
<211>  9 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR2 
 
<400>  240 
gatgcatcc                                                                9 
 
 
<210>  241 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  241 
cagtcttatg gcagcggctt tgtggtc                                           27 
 
 
<210>  242 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  242 
cagcaatatt atggtactcc gtacact                                           27 
 
 
<210>  243 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  243 
cagtctcatg ataccagccg tcaggcggtt                                        30 
 
 
<210>  244 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  244 
atgcaagctc tacaaacccc gtacact                                           27 
 
 
<210>  245 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  245 
atgcaaggta tacaaacccc cctcact                                           27 
 
 
<210>  246 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  246 
cagtcttttg atagcagcat tcaacatgtg gtc                                    33 
 
 
<210>  247 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  247 
cagtcttatg atggcagcgc ttgggtg                                           27 
 
 
<210>  248 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  248 
cagtcttttg atagcggcaa tcaacgggtg gtt                                    33 
 
 
<210>  249 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  249 
cagtcctatg acaacagcct gtttgtggta                                        30 
 
 
<210>  250 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  250 
cagtcttatg atgaaaacat tcgggtg                                           27 
 
 
<210>  251 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  251 
cagcagtatg ccagttcacg gacg                                              24 
 
 
<210>  252 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  252 
ggaacgtggg atagtaggct gagtgttggc gtg                                    33 
 
 
<210>  253 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  253 
caacagagtt acattacccc tcagacg                                           27 
 
 
<210>  254 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  254 
cagtcttatg atagcagcaa ttgggtg                                           27 
 
 
<210>  255 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  255 
cagtcttatg atagcagcaa tcgggtg                                           27 
 
 
<210>  256 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  256 
ctgcaatatg attctttccc tctcact                                           27 
 
 
<210>  257 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  257 
gcttcatttt catccagcag cactctctta gtg                                    33 
 
 
<210>  258 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  258 
cagtcttatg ataggaccaa taagagggtt                                        30 
 
 
<210>  259 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  259 
cagtcttatg ataataacat tcaggtg                                           27 
 
 
<210>  260 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  260 
cagtcttatg atagcagcaa ccttcagtgg gtg                                    33 
 
 
<210>  261 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  261 
cagtcttatg atatcagcaa tccggtg                                           27 
 
 
<210>  262 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  262 
catcaatttc ggaggtccgt gtccact                                           27 
 
 
<210>  263 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  263 
cagtcttatg atggcgtcaa tcgcggcgtg ata                                    33 
 
 
<210>  264 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  264 
cagtcttatg atcgtcccaa tcatgtggtg                                        30 
 
 
<210>  265 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  265 
caacagagtt acaatcttcc gcgcact                                           27 
 
 
<210>  266 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  light chain CDR3 
 
<400>  266 
cagcagtatg gaagctcgcc tcggacg                                           27 
 
 
<210>  267 
<211>  330 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1A5 heavy chain variable domain 
 
<400>  267 
caggtgcagc tgcaggagtc ggggggaggc ttggtacagc ctggggggtc cctgagactc       60 
 
tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120 
 
ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180 
 
gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240 
 
ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagattac      300 
 
ttcaggtggt tatggggcca gggaaccctg                                       330 
 
 
<210>  268 
<211>  345 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1A8 heavy chain variable domain 
 
<400>  268 
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60 
 
acctgcactg tctctggtgt ctccatcagc agtagaagtg accactgggg ctgggtccgc      120 
 
cagcccccag ggaaggggct ggagtggatt ggaagtatct cttatagtgg gagcacctac      180 
 
tacaacccgt ccctcaagag ccgagtcacc atatccgtag acacctccaa gaaccaactc      240 
 
tccctgaagc tgagctctgt gaccgccgca gacacggctg tctattactg tgcgagactc      300 
 
gcttcccttt attctacttt tgatatctgg ggccacggca ccctg                      345 
 
 
<210>  269 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1B2 heavy chain variable domain 
 
<400>  269 
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60 
 
tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180 
 
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gactggggag      300 
 
atggcagggg attttgacta ctggggccag ggcaccctg                             339 
 
 
<210>  270 
<211>  360 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1B11 heavy chain variable domain 
 
<400>  270 
gaagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagacaac      300 
 
cccgggtata gcagcagctg gtcccccaac tggttcgacc cctggggcca gggaaccctg      360 
 
 
<210>  271 
<211>  342 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1C2 heavy chain variable domain 
 
<400>  271 
gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180 
 
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagctcttcg      300 
 
gctggtacgt tctactttga ctactggggc cagggcaccc tg                         342 
 
 
<210>  272 
<211>  348 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1C3 heavy chain variable domain 
 
<400>  272 
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60 
 
tcctgcaagg catctggata ccccttcagc acttactata tacactgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaata atcgacccta gtggtggtag cacaagctac      180 
 
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240 
 
atggagctga ggagcctaag atctgacgac acggccgtgt tttactgtgc gagagttgcc      300 
 
gagcaacacc tggactacta ctttgactac tggggccagg gaaccctg                   348 
 
 
<210>  273 
<211>  342 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1D12 heavy chain variable domain 
 
<400>  273 
gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180 
 
gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240 
 
atggagctga ggagcctgag atctgaggac acggccgtgt attactgtgc gaggcttgag      300 
 
tggctacgtg gtgcttttga tatctggggc caagggacca cg                         342 
 
 
<210>  274 
<211>  354 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1E5 heavy chain variable domain 
 
<400>  274 
gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagcgtta      300 
 
gtcggaaagt ggttattact acggggcttt gactactggg gccagggaac cctg            354 
 
 
<210>  275 
<211>  354 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1F4 heavy chain variable domain 
 
<400>  275 
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60 
 
acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120 
 
cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180 
 
aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240 
 
cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300 
 
agagaaaagg gcatcgaagg gcctgcgttc gacccctggg gccagggaac cctg            354 
 
 
<210>  276 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  1H7 heavy chain variable domain 
 
<400>  276 
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgcccctc       60 
 
acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120 
 
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180 
 
ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agggaggtgg      300 
 
ctgcggggtg cttttgatat ctggggccaa gggacaatg                             339 
 
 
<210>  277 
<211>  357 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2C9 heavy chain variable domain 
 
<400>  277 
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagacatggg      300 
 
ggggtgggag ctactacggg ttactactac atggacgtct ggggcaaagg gaccacg         357 
 
 
<210>  278 
<211>  336 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2C10 heavy chain variable domain 
 
<400>  278 
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60 
 
acctgcggtg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagtcc      120 
 
ccagggaagg ggctggagtg gattggggaa atcaattata gaggaaacac caactacaac      180 
 
ccgtctctca agagtcgagt caccatatcg gtagacacgt ccaaaaacca gttctcccta      240 
 
aacgtgaact ctgtgaccgc cgcggacacg gctgtgtatt attgtgcgag atgggacggt      300 
 
ggtaactccg tggaccactg gggccaggga accctg                                336 
 
 
<210>  279 
<211>  351 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2C12 heavy chain variable domain 
 
<400>  279 
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60 
 
tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120 
 
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180 
 
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240 
 
ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagaggggga      300 
 
cgattccact actactacta tgccatggac gtctggggcc aagggaccac g               351 
 
 
<210>  280 
<211>  342 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2D3 heavy chain variable domain 
 
<400>  280 
gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagcagtggc      300 
 
tggttaaggg gtgcttttga tatctggggc caagggacaa tg                         342 
 
 
<210>  281 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2G7 heavy chain variable domain 
 
<400>  281 
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60 
 
acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120 
 
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180 
 
ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agggaaatgg      300 
 
ttacggggtg cttttgatat ctggggccaa gggacaatg                             339 
 
 
<210>  282 
<211>  354 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  2H4 heavy chain variable domain 
 
<400>  282 
caggtccagc tggtacagtc tggggctgag gtgacgaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggata caccttcagc ggctactata tacactgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatggggcgg gtcaacccta atagtggtgg cacaaagtat      180 
 
gcacagaagt ttcaggacag ggtcacgttg accagggaca cgtccatcag tactgcctac      240 
 
atggaattga ccagtctgag atctgacgac acggccatgt atttctgtgc gagaggtggc      300 
 
aggcccggtt tacctgcagc tggctatatt gactactggg gccagggcac cctg            354 
 
 
<210>  283 
<211>  348 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3A11 heavy chain variable domain 
 
<400>  283 
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggtta cacgtttagc acctatgata tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggatgg atcagcactt acaatggtga cacaaactat      180 
 
gcacagaagt tccagggcag agtcaccatg accacagaca cgtccacgag cacaatctac      240 
 
atggagctga ggagcctgag atctgacgac acggccgtct attactgtgc gaggggagat      300 
 
agcagtgtcg ggtacgaata cttccaacac tggggccagg gaaccctg                   348 
 
 
<210>  284 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3C5 heavy chain variable domain 
 
<400>  284 
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60 
 
acctgcggtg tctatggtgg gtccttaagt ggttactact ggagctggat ccgccagccc      120 
 
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180 
 
ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag acggtggtgg      300 
 
ctacgaggtg cttttgatat ctggggccaa gggaccacg                             339 
 
 
<210>  285 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3D2, 3D11 heavy chain variable domain 
 
<400>  285 
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60 
 
acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120 
 
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180 
 
ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag acggtggtgg      300 
 
ctacgaggtg cttttgatat ctggggccaa gggaccacg                             339 
 
 
<210>  286 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3E9 heavy chain variable domain 
 
<400>  286 
gaagtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180 
 
gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240 
 
atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaggcatt      300 
 
attactatga tatcggacta ctggggccag ggaaccctg                             339 
 
 
<210>  287 
<211>  336 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3F1 heavy chain variable domain 
 
<400>  287 
caggtgcagc tggtgcaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60 
 
tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120 
 
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180 
 
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240 
 
ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagacggt      300 
 
gggggaggta tggacgtctg gggccaaggg accacg                                336 
 
 
<210>  288 
<211>  339 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3F11 heavy chain variable domain 
 
<400>  288 
gaggtccagc tggtacagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggtta cacctttagc agctctggta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggatgg atcagcactt acaatggtaa cacaaactat      180 
 
gcacagaatt tccagggcag agtcaccatg accacagaca cgtccacgag cacagtctac      240 
 
atggagttga ggggcctgac atctgacgac acggccgtgt attactgtgc tacgagtata      300 
 
gcggtggctg gtattgacta ctggggccag ggcaccctg                             339 
 
 
<210>  289 
<211>  348 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3H7 heavy chain variable domain 
 
<400>  289 
caggtgcagc tggtgcaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactg       60 
 
tcctgtgcag cgtctggatt caccttcagt aactatggca tgcactgggt ccgccaggct      120 
 
ccgggcaagg ggctggagtg ggtggcagtt atatggcatg atggaaccaa taaatactat      180 
 
gcagactccg tgaagggccg attcaccgtc tccagagaca attcgaagaa cactctgtat      240 
 
ttgcaaatgg acactctgag agccgaggac acggctgtgt attactgtgt gagagatcag      300 
 
ggggccggtg tttggaatgg ttattcctac tggggccagg gaaccctg                   348 
 
 
<210>  290 
<211>  360 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  3H11 heavy chain variable domain 
 
<400>  290 
caggtgcagc tggtgcaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60 
 
tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180 
 
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgaa cacagtctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagctcagta      300 
 
gtaccagctg ctatttacga ctactactac ggtatggacg tctggggcca agggaccacg      360 
 
 
<210>  291 
<211>  342 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  5A6 heavy chain variable domain 
 
<400>  291 
caggtgcagc tgcaggagtc ggggggaggc ttggtacagc ctggagggtc cctgagactc       60 
 
tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct      120 
 
ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180 
 
gcagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240 
 
ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagactgatt      300 
 
actatggttc ggggagagga ctactggggc cagggcaccc tg                         342 
 
 
<210>  292 
<211>  336 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  6F8 heavy chain variable domain 
 
<400>  292 
caggtgcagc tggtggagtc cgggggaggc ttggtacagc ctggggggtc cctgagactc       60 
 
tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120 
 
ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180 
 
gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240 
 
caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agactacggt      300 
 
gactattact ttgactactg gggccagggc accctg                                336 
 
 
<210>  293 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  293 
ggattcacct ttagcagcta tgcc                                              24 
 
 
<210>  294 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  294 
ggtgtctcca tcagcagtag aagtgaccac                                        30 
 
 
<210>  295 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  295 
ggatacacct tcaccagcta ctat                                              24 
 
 
<210>  296 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  296 
ggaggcacct tcagcagcta tgct                                              24 
 
 
<210>  297 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  297 
ggatacccct tcagcactta ctat                                              24 
 
 
<210>  298 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  298 
ggggacagtg tctctagcaa cagtgctgct                                        30 
 
 
<210>  299 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  299 
ggtgggtcct tcagtggtta ctac                                              24 
 
 
<210>  300 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  300 
ggattcacct tcagtagcta tgct                                              24 
 
 
<210>  301 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  301 
ggatacacct tcagcggcta ctat                                              24 
 
 
<210>  302 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  302 
ggttacacgt ttagcaccta tgat                                              24 
 
 
<210>  303 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  303 
ggtgggtcct taagtggtta ctac                                              24 
 
 
<210>  304 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  304 
ggttacacct ttaccagcta tggt                                              24 
 
 
<210>  305 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  305 
ggattcacct tcagtagcta tggc                                              24 
 
 
<210>  306 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  306 
ggttacacct ttagcagctc tggt                                              24 
 
 
<210>  307 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  307 
ggattcacct tcagtaacta tggc                                              24 
 
 
<210>  308 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  308 
ggattcacct tcagtagtta tgaa                                              24 
 
 
<210>  309 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR1 
 
<400>  309 
gggttcaccg tcagtagcaa ctac                                              24 
 
 
<210>  310 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  310 
attagtggta gtggtggtag caca                                              24 
 
 
<210>  311 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  311 
atctcttata gtgggagcac c                                                 21 
 
 
<210>  312 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  312 
atcaacccta gtggtggtag caca                                              24 
 
 
<210>  313 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  313 
atcatcccta tctttggtac agca                                              24 
 
 
<210>  314 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  314 
atcgacccta gtggtggtag caca                                              24 
 
 
<210>  315 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  315 
atcagcgctt acaatggtaa caca                                              24 
 
 
<210>  316 
<211>  27 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  316 
acatactaca ggtccaagtg gtataat                                           27 
 
 
<210>  317 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  317 
atcaatcata gtggaagcac c                                                 21 
 
 
<210>  318 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  318 
atcatcccta tccttggtat agca                                              24 
 
 
<210>  319 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  319 
atcaattata gaggaaacac c                                                 21 
 
 
<210>  320 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  320 
atatcatatg atggaagtaa taaa                                              24 
 
 
<210>  321 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  321 
gtcaacccta atagtggtgg caca                                              24 
 
 
<210>  322 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  322 
atcagcactt acaatggtga caca                                              24 
 
 
<210>  323 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  323 
atcagcactt acaatggtaa caca                                              24 
 
 
<210>  324 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  324 
atatggcatg atggaaccaa taaa                                              24 
 
 
<210>  325 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  325 
atatcatatg atggaagcaa taaa                                              24 
 
 
<210>  326 
<211>  21 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR2 
 
<400>  326 
atttatagcg gtggtagcac a                                                 21 
 
 
<210>  327 
<211>  24 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  327 
gcgaaagatt acttcaggtg gtta                                              24 
 
 
<210>  328 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  328 
gcgagactcg cttcccttta ttctactttt gatatc                                 36 
 
 
<210>  329 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  329 
gcgactgggg agatggcagg ggattttgac tac                                    33 
 
 
<210>  330 
<211>  54 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  330 
gcgagagaca accccgggta tagcagcagc tggtccccca actggttcga cccc             54 
 
 
<210>  331 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  331 
gcgagctctt cggctggtac gttctacttt gactac                                 36 
 
 
<210>  332 
<211>  42 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  332 
gcgagagttg ccgagcaaca cctggactac tactttgact ac                          42 
 
 
<210>  333 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  333 
gcgaggcttg agtggctacg tggtgctttt gatatc                                 36 
 
 
<210>  334 
<211>  48 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  334 
gcgagagcgt tagtcggaaa gtggttatta ctacggggct ttgactac                    48 
 
 
<210>  335 
<211>  39 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  335 
gcaagagaaa agggcatcga agggcctgcg ttcgacccc                              39 
 
 
<210>  336 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  336 
gcgagaggga ggtggctgcg gggtgctttt gatatc                                 36 
 
 
<210>  337 
<211>  51 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  337 
gcgagacatg ggggggtggg agctactacg ggttactact acatggacgt c                51 
 
 
<210>  338 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  338 
gcgagatggg acggtggtaa ctccgtggac cac                                    33 
 
 
<210>  339 
<211>  45 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  339 
gcgagagggg gacgattcca ctactactac tatgccatgg acgtc                       45 
 
 
<210>  340 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  340 
gcgagcagtg gctggttaag gggtgctttt gatatc                                 36 
 
 
<210>  341 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  341 
gcgagaggga aatggttacg gggtgctttt gatatc                                 36 
 
 
<210>  342 
<211>  48 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  342 
gcgagaggtg gcaggcccgg tttacctgca gctggctata ttgactac                    48 
 
 
<210>  343 
<211>  42 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  343 
gcgaggggag atagcagtgt cgggtacgaa tacttccaac ac                          42 
 
 
<210>  344 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  344 
gcgagacggt ggtggctacg aggtgctttt gatatc                                 36 
 
 
<210>  345 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  345 
gcgagaggca ttattactat gatatcggac tac                                    33 
 
 
<210>  346 
<211>  30 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  346 
gcgagagacg gtgggggagg tatggacgtc                                        30 
 
 
<210>  347 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  347 
gctacgagta tagcggtggc tggtattgac tac                                    33 
 
 
<210>  348 
<211>  42 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  348 
gtgagagatc agggggccgg tgtttggaat ggttattcct ac                          42 
 
 
<210>  349 
<211>  54 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  349 
gcgagctcag tagtaccagc tgctatttac gactactact acggtatgga cgtc             54 
 
 
<210>  350 
<211>  36 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  350 
gcgagactga ttactatggt tcggggagag gactac                                 36 
 
 
<210>  351 
<211>  33 
<212>  DNA 
<213>  Homo sapiens 
 
<220>   
<223>  heavy chain CDR3 
 
<400>  351 
gcgagagact acggtgacta ttactttgac tac                                    33 
 
 
<210>  352 
<211>  29903 
<212>  DNA 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  complete genome 
 
<400>  352 
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct       60 
 
gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact      120 
 
cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc      180 
 
ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt      240 
 
cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac      300 
 
acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg      360 
 
agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg      420 
 
cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa      480 
 
acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact      540 
 
cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg      600 
 
cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg      660 
 
tggccatagt tacggcgccg atctaaagtc atttgactta ggcgacgagc ttggcactga      720 
 
tccttatgaa gattttcaag aaaactggaa cactaaacat agcagtggtg ttacccgtga      780 
 
actcatgcgt gagcttaacg gaggggcata cactcgctat gtcgataaca acttctgtgg      840 
 
ccctgatggc taccctcttg agtgcattaa agaccttcta gcacgtgctg gtaaagcttc      900 
 
atgcactttg tccgaacaac tggactttat tgacactaag aggggtgtat actgctgccg      960 
 
tgaacatgag catgaaattg cttggtacac ggaacgttct gaaaagagct atgaattgca     1020 
 
gacacctttt gaaattaaat tggcaaagaa atttgacacc ttcaatgggg aatgtccaaa     1080 
 
ttttgtattt cccttaaatt ccataatcaa gactattcaa ccaagggttg aaaagaaaaa     1140 
 
gcttgatggc tttatgggta gaattcgatc tgtctatcca gttgcgtcac caaatgaatg     1200 
 
caaccaaatg tgcctttcaa ctctcatgaa gtgtgatcat tgtggtgaaa cttcatggca     1260 
 
gacgggcgat tttgttaaag ccacttgcga attttgtggc actgagaatt tgactaaaga     1320 
 
aggtgccact acttgtggtt acttacccca aaatgctgtt gttaaaattt attgtccagc     1380 
 
atgtcacaat tcagaagtag gacctgagca tagtcttgcc gaataccata atgaatctgg     1440 
 
cttgaaaacc attcttcgta agggtggtcg cactattgcc tttggaggct gtgtgttctc     1500 
 
ttatgttggt tgccataaca agtgtgccta ttgggttcca cgtgctagcg ctaacatagg     1560 
 
ttgtaaccat acaggtgttg ttggagaagg ttccgaaggt cttaatgaca accttcttga     1620 
 
aatactccaa aaagagaaag tcaacatcaa tattgttggt gactttaaac ttaatgaaga     1680 
 
gatcgccatt attttggcat ctttttctgc ttccacaagt gcttttgtgg aaactgtgaa     1740 
 
aggtttggat tataaagcat tcaaacaaat tgttgaatcc tgtggtaatt ttaaagttac     1800 
 
aaaaggaaaa gctaaaaaag gtgcctggaa tattggtgaa cagaaatcaa tactgagtcc     1860 
 
tctttatgca tttgcatcag aggctgctcg tgttgtacga tcaattttct cccgcactct     1920 
 
tgaaactgct caaaattctg tgcgtgtttt acagaaggcc gctataacaa tactagatgg     1980 
 
aatttcacag tattcactga gactcattga tgctatgatg ttcacatctg atttggctac     2040 
 
taacaatcta gttgtaatgg cctacattac aggtggtgtt gttcagttga cttcgcagtg     2100 
 
gctaactaac atctttggca ctgtttatga aaaactcaaa cccgtccttg attggcttga     2160 
 
agagaagttt aaggaaggtg tagagtttct tagagacggt tgggaaattg ttaaatttat     2220 
 
ctcaacctgt gcttgtgaaa ttgtcggtgg acaaattgtc acctgtgcaa aggaaattaa     2280 
 
ggagagtgtt cagacattct ttaagcttgt aaataaattt ttggctttgt gtgctgactc     2340 
 
tatcattatt ggtggagcta aacttaaagc cttgaattta ggtgaaacat ttgtcacgca     2400 
 
ctcaaaggga ttgtacagaa agtgtgttaa atccagagaa gaaactggcc tactcatgcc     2460 
 
tctaaaagcc ccaaaagaaa ttatcttctt agagggagaa acacttccca cagaagtgtt     2520 
 
aacagaggaa gttgtcttga aaactggtga tttacaacca ttagaacaac ctactagtga     2580 
 
agctgttgaa gctccattgg ttggtacacc agtttgtatt aacgggctta tgttgctcga     2640 
 
aatcaaagac acagaaaagt actgtgccct tgcacctaat atgatggtaa caaacaatac     2700 
 
cttcacactc aaaggcggtg caccaacaaa ggttactttt ggtgatgaca ctgtgataga     2760 
 
agtgcaaggt tacaagagtg tgaatatcac ttttgaactt gatgaaagga ttgataaagt     2820 
 
acttaatgag aagtgctctg cctatacagt tgaactcggt acagaagtaa atgagttcgc     2880 
 
ctgtgttgtg gcagatgctg tcataaaaac tttgcaacca gtatctgaat tacttacacc     2940 
 
actgggcatt gatttagatg agtggagtat ggctacatac tacttatttg atgagtctgg     3000 
 
tgagtttaaa ttggcttcac atatgtattg ttctttctac cctccagatg aggatgaaga     3060 
 
agaaggtgat tgtgaagaag aagagtttga gccatcaact caatatgagt atggtactga     3120 
 
agatgattac caaggtaaac ctttggaatt tggtgccact tctgctgctc ttcaacctga     3180 
 
agaagagcaa gaagaagatt ggttagatga tgatagtcaa caaactgttg gtcaacaaga     3240 
 
cggcagtgag gacaatcaga caactactat tcaaacaatt gttgaggttc aacctcaatt     3300 
 
agagatggaa cttacaccag ttgttcagac tattgaagtg aatagtttta gtggttattt     3360 
 
aaaacttact gacaatgtat acattaaaaa tgcagacatt gtggaagaag ctaaaaaggt     3420 
 
aaaaccaaca gtggttgtta atgcagccaa tgtttacctt aaacatggag gaggtgttgc     3480 
 
aggagcctta aataaggcta ctaacaatgc catgcaagtt gaatctgatg attacatagc     3540 
 
tactaatgga ccacttaaag tgggtggtag ttgtgtttta agcggacaca atcttgctaa     3600 
 
acactgtctt catgttgtcg gcccaaatgt taacaaaggt gaagacattc aacttcttaa     3660 
 
gagtgcttat gaaaatttta atcagcacga agttctactt gcaccattat tatcagctgg     3720 
 
tatttttggt gctgacccta tacattcttt aagagtttgt gtagatactg ttcgcacaaa     3780 
 
tgtctactta gctgtctttg ataaaaatct ctatgacaaa cttgtttcaa gctttttgga     3840 
 
aatgaagagt gaaaagcaag ttgaacaaaa gatcgctgag attcctaaag aggaagttaa     3900 
 
gccatttata actgaaagta aaccttcagt tgaacagaga aaacaagatg ataagaaaat     3960 
 
caaagcttgt gttgaagaag ttacaacaac tctggaagaa actaagttcc tcacagaaaa     4020 
 
cttgttactt tatattgaca ttaatggcaa tcttcatcca gattctgcca ctcttgttag     4080 
 
tgacattgac atcactttct taaagaaaga tgctccatat atagtgggtg atgttgttca     4140 
 
agagggtgtt ttaactgctg tggttatacc tactaaaaag gctggtggca ctactgaaat     4200 
 
gctagcgaaa gctttgagaa aagtgccaac agacaattat ataaccactt acccgggtca     4260 
 
gggtttaaat ggttacactg tagaggaggc aaagacagtg cttaaaaagt gtaaaagtgc     4320 
 
cttttacatt ctaccatcta ttatctctaa tgagaagcaa gaaattcttg gaactgtttc     4380 
 
ttggaatttg cgagaaatgc ttgcacatgc agaagaaaca cgcaaattaa tgcctgtctg     4440 
 
tgtggaaact aaagccatag tttcaactat acagcgtaaa tataagggta ttaaaataca     4500 
 
agagggtgtg gttgattatg gtgctagatt ttacttttac accagtaaaa caactgtagc     4560 
 
gtcacttatc aacacactta acgatctaaa tgaaactctt gttacaatgc cacttggcta     4620 
 
tgtaacacat ggcttaaatt tggaagaagc tgctcggtat atgagatctc tcaaagtgcc     4680 
 
agctacagtt tctgtttctt cacctgatgc tgttacagcg tataatggtt atcttacttc     4740 
 
ttcttctaaa acacctgaag aacattttat tgaaaccatc tcacttgctg gttcctataa     4800 
 
agattggtcc tattctggac aatctacaca actaggtata gaatttctta agagaggtga     4860 
 
taaaagtgta tattacacta gtaatcctac cacattccac ctagatggtg aagttatcac     4920 
 
ctttgacaat cttaagacac ttctttcttt gagagaagtg aggactatta aggtgtttac     4980 
 
aacagtagac aacattaacc tccacacgca agttgtggac atgtcaatga catatggaca     5040 
 
acagtttggt ccaacttatt tggatggagc tgatgttact aaaataaaac ctcataattc     5100 
 
acatgaaggt aaaacatttt atgttttacc taatgatgac actctacgtg ttgaggcttt     5160 
 
tgagtactac cacacaactg atcctagttt tctgggtagg tacatgtcag cattaaatca     5220 
 
cactaaaaag tggaaatacc cacaagttaa tggtttaact tctattaaat gggcagataa     5280 
 
caactgttat cttgccactg cattgttaac actccaacaa atagagttga agtttaatcc     5340 
 
acctgctcta caagatgctt attacagagc aagggctggt gaagctgcta acttttgtgc     5400 
 
acttatctta gcctactgta ataagacagt aggtgagtta ggtgatgtta gagaaacaat     5460 
 
gagttacttg tttcaacatg ccaatttaga ttcttgcaaa agagtcttga acgtggtgtg     5520 
 
taaaacttgt ggacaacagc agacaaccct taagggtgta gaagctgtta tgtacatggg     5580 
 
cacactttct tatgaacaat ttaagaaagg tgttcagata ccttgtacgt gtggtaaaca     5640 
 
agctacaaaa tatctagtac aacaggagtc accttttgtt atgatgtcag caccacctgc     5700 
 
tcagtatgaa cttaagcatg gtacatttac ttgtgctagt gagtacactg gtaattacca     5760 
 
gtgtggtcac tataaacata taacttctaa agaaactttg tattgcatag acggtgcttt     5820 
 
acttacaaag tcctcagaat acaaaggtcc tattacggat gttttctaca aagaaaacag     5880 
 
ttacacaaca accataaaac cagttactta taaattggat ggtgttgttt gtacagaaat     5940 
 
tgaccctaag ttggacaatt attataagaa agacaattct tatttcacag agcaaccaat     6000 
 
tgatcttgta ccaaaccaac catatccaaa cgcaagcttc gataatttta agtttgtatg     6060 
 
tgataatatc aaatttgctg atgatttaaa ccagttaact ggttataaga aacctgcttc     6120 
 
aagagagctt aaagttacat ttttccctga cttaaatggt gatgtggtgg ctattgatta     6180 
 
taaacactac acaccctctt ttaagaaagg agctaaattg ttacataaac ctattgtttg     6240 
 
gcatgttaac aatgcaacta ataaagccac gtataaacca aatacctggt gtatacgttg     6300 
 
tctttggagc acaaaaccag ttgaaacatc aaattcgttt gatgtactga agtcagagga     6360 
 
cgcgcaggga atggataatc ttgcctgcga agatctaaaa ccagtctctg aagaagtagt     6420 
 
ggaaaatcct accatacaga aagacgttct tgagtgtaat gtgaaaacta ccgaagttgt     6480 
 
aggagacatt atacttaaac cagcaaataa tagtttaaaa attacagaag aggttggcca     6540 
 
cacagatcta atggctgctt atgtagacaa ttctagtctt actattaaga aacctaatga     6600 
 
attatctaga gtattaggtt tgaaaaccct tgctactcat ggtttagctg ctgttaatag     6660 
 
tgtcccttgg gatactatag ctaattatgc taagcctttt cttaacaaag ttgttagtac     6720 
 
aactactaac atagttacac ggtgtttaaa ccgtgtttgt actaattata tgccttattt     6780 
 
ctttacttta ttgctacaat tgtgtacttt tactagaagt acaaattcta gaattaaagc     6840 
 
atctatgccg actactatag caaagaatac tgttaagagt gtcggtaaat tttgtctaga     6900 
 
ggcttcattt aattatttga agtcacctaa tttttctaaa ctgataaata ttataatttg     6960 
 
gtttttacta ttaagtgttt gcctaggttc tttaatctac tcaaccgctg ctttaggtgt     7020 
 
tttaatgtct aatttaggca tgccttctta ctgtactggt tacagagaag gctatttgaa     7080 
 
ctctactaat gtcactattg caacctactg tactggttct ataccttgta gtgtttgtct     7140 
 
tagtggttta gattctttag acacctatcc ttctttagaa actatacaaa ttaccatttc     7200 
 
atcttttaaa tgggatttaa ctgcttttgg cttagttgca gagtggtttt tggcatatat     7260 
 
tcttttcact aggtttttct atgtacttgg attggctgca atcatgcaat tgtttttcag     7320 
 
ctattttgca gtacatttta ttagtaattc ttggcttatg tggttaataa ttaatcttgt     7380 
 
acaaatggcc ccgatttcag ctatggttag aatgtacatc ttctttgcat cattttatta     7440 
 
tgtatggaaa agttatgtgc atgttgtaga cggttgtaat tcatcaactt gtatgatgtg     7500 
 
ttacaaacgt aatagagcaa caagagtcga atgtacaact attgttaatg gtgttagaag     7560 
 
gtccttttat gtctatgcta atggaggtaa aggcttttgc aaactacaca attggaattg     7620 
 
tgttaattgt gatacattct gtgctggtag tacatttatt agtgatgaag ttgcgagaga     7680 
 
cttgtcacta cagtttaaaa gaccaataaa tcctactgac cagtcttctt acatcgttga     7740 
 
tagtgttaca gtgaagaatg gttccatcca tctttacttt gataaagctg gtcaaaagac     7800 
 
ttatgaaaga cattctctct ctcattttgt taacttagac aacctgagag ctaataacac     7860 
 
taaaggttca ttgcctatta atgttatagt ttttgatggt aaatcaaaat gtgaagaatc     7920 
 
atctgcaaaa tcagcgtctg tttactacag tcagcttatg tgtcaaccta tactgttact     7980 
 
agatcaggca ttagtgtctg atgttggtga tagtgcggaa gttgcagtta aaatgtttga     8040 
 
tgcttacgtt aatacgtttt catcaacttt taacgtacca atggaaaaac tcaaaacact     8100 
 
agttgcaact gcagaagctg aacttgcaaa gaatgtgtcc ttagacaatg tcttatctac     8160 
 
ttttatttca gcagctcggc aagggtttgt tgattcagat gtagaaacta aagatgttgt     8220 
 
tgaatgtctt aaattgtcac atcaatctga catagaagtt actggcgata gttgtaataa     8280 
 
ctatatgctc acctataaca aagttgaaaa catgacaccc cgtgaccttg gtgcttgtat     8340 
 
tgactgtagt gcgcgtcata ttaatgcgca ggtagcaaaa agtcacaaca ttgctttgat     8400 
 
atggaacgtt aaagatttca tgtcattgtc tgaacaacta cgaaaacaaa tacgtagtgc     8460 
 
tgctaaaaag aataacttac cttttaagtt gacatgtgca actactagac aagttgttaa     8520 
 
tgttgtaaca acaaagatag cacttaaggg tggtaaaatt gttaataatt ggttgaagca     8580 
 
gttaattaaa gttacacttg tgttcctttt tgttgctgct attttctatt taataacacc     8640 
 
tgttcatgtc atgtctaaac atactgactt ttcaagtgaa atcataggat acaaggctat     8700 
 
tgatggtggt gtcactcgtg acatagcatc tacagatact tgttttgcta acaaacatgc     8760 
 
tgattttgac acatggttta gccagcgtgg tggtagttat actaatgaca aagcttgccc     8820 
 
attgattgct gcagtcataa caagagaagt gggttttgtc gtgcctggtt tgcctggcac     8880 
 
gatattacgc acaactaatg gtgacttttt gcatttctta cctagagttt ttagtgcagt     8940 
 
tggtaacatc tgttacacac catcaaaact tatagagtac actgactttg caacatcagc     9000 
 
ttgtgttttg gctgctgaat gtacaatttt taaagatgct tctggtaagc cagtaccata     9060 
 
ttgttatgat accaatgtac tagaaggttc tgttgcttat gaaagtttac gccctgacac     9120 
 
acgttatgtg ctcatggatg gctctattat tcaatttcct aacacctacc ttgaaggttc     9180 
 
tgttagagtg gtaacaactt ttgattctga gtactgtagg cacggcactt gtgaaagatc     9240 
 
agaagctggt gtttgtgtat ctactagtgg tagatgggta cttaacaatg attattacag     9300 
 
atctttacca ggagttttct gtggtgtaga tgctgtaaat ttacttacta atatgtttac     9360 
 
accactaatt caacctattg gtgctttgga catatcagca tctatagtag ctggtggtat     9420 
 
tgtagctatc gtagtaacat gccttgccta ctattttatg aggtttagaa gagcttttgg     9480 
 
tgaatacagt catgtagttg cctttaatac tttactattc cttatgtcat tcactgtact     9540 
 
ctgtttaaca ccagtttact cattcttacc tggtgtttat tctgttattt acttgtactt     9600 
 
gacattttat cttactaatg atgtttcttt tttagcacat attcagtgga tggttatgtt     9660 
 
cacaccttta gtacctttct ggataacaat tgcttatatc atttgtattt ccacaaagca     9720 
 
tttctattgg ttctttagta attacctaaa gagacgtgta gtctttaatg gtgtttcctt     9780 
 
tagtactttt gaagaagctg cgctgtgcac ctttttgtta aataaagaaa tgtatctaaa     9840 
 
gttgcgtagt gatgtgctat tacctcttac gcaatataat agatacttag ctctttataa     9900 
 
taagtacaag tattttagtg gagcaatgga tacaactagc tacagagaag ctgcttgttg     9960 
 
tcatctcgca aaggctctca atgacttcag taactcaggt tctgatgttc tttaccaacc    10020 
 
accacaaacc tctatcacct cagctgtttt gcagagtggt tttagaaaaa tggcattccc    10080 
 
atctggtaaa gttgagggtt gtatggtaca agtaacttgt ggtacaacta cacttaacgg    10140 
 
tctttggctt gatgacgtag tttactgtcc aagacatgtg atctgcacct ctgaagacat    10200 
 
gcttaaccct aattatgaag atttactcat tcgtaagtct aatcataatt tcttggtaca    10260 
 
ggctggtaat gttcaactca gggttattgg acattctatg caaaattgtg tacttaagct    10320 
 
taaggttgat acagccaatc ctaagacacc taagtataag tttgttcgca ttcaaccagg    10380 
 
acagactttt tcagtgttag cttgttacaa tggttcacca tctggtgttt accaatgtgc    10440 
 
tatgaggccc aatttcacta ttaagggttc attccttaat ggttcatgtg gtagtgttgg    10500 
 
ttttaacata gattatgact gtgtctcttt ttgttacatg caccatatgg aattaccaac    10560 
 
tggagttcat gctggcacag acttagaagg taacttttat ggaccttttg ttgacaggca    10620 
 
aacagcacaa gcagctggta cggacacaac tattacagtt aatgttttag cttggttgta    10680 
 
cgctgctgtt ataaatggag acaggtggtt tctcaatcga tttaccacaa ctcttaatga    10740 
 
ctttaacctt gtggctatga agtacaatta tgaacctcta acacaagacc atgttgacat    10800 
 
actaggacct ctttctgctc aaactggaat tgccgtttta gatatgtgtg cttcattaaa    10860 
 
agaattactg caaaatggta tgaatggacg taccatattg ggtagtgctt tattagaaga    10920 
 
tgaatttaca ccttttgatg ttgttagaca atgctcaggt gttactttcc aaagtgcagt    10980 
 
gaaaagaaca atcaagggta cacaccactg gttgttactc acaattttga cttcactttt    11040 
 
agttttagtc cagagtactc aatggtcttt gttctttttt ttgtatgaaa atgccttttt    11100 
 
accttttgct atgggtatta ttgctatgtc tgcttttgca atgatgtttg tcaaacataa    11160 
 
gcatgcattt ctctgtttgt ttttgttacc ttctcttgcc actgtagctt attttaatat    11220 
 
ggtctatatg cctgctagtt gggtgatgcg tattatgaca tggttggata tggttgatac    11280 
 
tagtttgtct ggttttaagc taaaagactg tgttatgtat gcatcagctg tagtgttact    11340 
 
aatccttatg acagcaagaa ctgtgtatga tgatggtgct aggagagtgt ggacacttat    11400 
 
gaatgtcttg acactcgttt ataaagttta ttatggtaat gctttagatc aagccatttc    11460 
 
catgtgggct cttataatct ctgttacttc taactactca ggtgtagtta caactgtcat    11520 
 
gtttttggcc agaggtattg tttttatgtg tgttgagtat tgccctattt tcttcataac    11580 
 
tggtaataca cttcagtgta taatgctagt ttattgtttc ttaggctatt tttgtacttg    11640 
 
ttactttggc ctcttttgtt tactcaaccg ctactttaga ctgactcttg gtgtttatga    11700 
 
ttacttagtt tctacacagg agtttagata tatgaattca cagggactac tcccacccaa    11760 
 
gaatagcata gatgccttca aactcaacat taaattgttg ggtgttggtg gcaaaccttg    11820 
 
tatcaaagta gccactgtac agtctaaaat gtcagatgta aagtgcacat cagtagtctt    11880 
 
actctcagtt ttgcaacaac tcagagtaga atcatcatct aaattgtggg ctcaatgtgt    11940 
 
ccagttacac aatgacattc tcttagctaa agatactact gaagcctttg aaaaaatggt    12000 
 
ttcactactt tctgttttgc tttccatgca gggtgctgta gacataaaca agctttgtga    12060 
 
agaaatgctg gacaacaggg caaccttaca agctatagcc tcagagttta gttcccttcc    12120 
 
atcatatgca gcttttgcta ctgctcaaga agcttatgag caggctgttg ctaatggtga    12180 
 
ttctgaagtt gttcttaaaa agttgaagaa gtctttgaat gtggctaaat ctgaatttga    12240 
 
ccgtgatgca gccatgcaac gtaagttgga aaagatggct gatcaagcta tgacccaaat    12300 
 
gtataaacag gctagatctg aggacaagag ggcaaaagtt actagtgcta tgcagacaat    12360 
 
gcttttcact atgcttagaa agttggataa tgatgcactc aacaacatta tcaacaatgc    12420 
 
aagagatggt tgtgttccct tgaacataat acctcttaca acagcagcca aactaatggt    12480 
 
tgtcatacca gactataaca catataaaaa tacgtgtgat ggtacaacat ttacttatgc    12540 
 
atcagcattg tgggaaatcc aacaggttgt agatgcagat agtaaaattg ttcaacttag    12600 
 
tgaaattagt atggacaatt cacctaattt agcatggcct cttattgtaa cagctttaag    12660 
 
ggccaattct gctgtcaaat tacagaataa tgagcttagt cctgttgcac tacgacagat    12720 
 
gtcttgtgct gccggtacta cacaaactgc ttgcactgat gacaatgcgt tagcttacta    12780 
 
caacacaaca aagggaggta ggtttgtact tgcactgtta tccgatttac aggatttgaa    12840 
 
atgggctaga ttccctaaga gtgatggaac tggtactatc tatacagaac tggaaccacc    12900 
 
ttgtaggttt gttacagaca cacctaaagg tcctaaagtg aagtatttat actttattaa    12960 
 
aggattaaac aacctaaata gaggtatggt acttggtagt ttagctgcca cagtacgtct    13020 
 
acaagctggt aatgcaacag aagtgcctgc caattcaact gtattatctt tctgtgcttt    13080 
 
tgctgtagat gctgctaaag cttacaaaga ttatctagct agtgggggac aaccaatcac    13140 
 
taattgtgtt aagatgttgt gtacacacac tggtactggt caggcaataa cagttacacc    13200 
 
ggaagccaat atggatcaag aatcctttgg tggtgcatcg tgttgtctgt actgccgttg    13260 
 
ccacatagat catccaaatc ctaaaggatt ttgtgactta aaaggtaagt atgtacaaat    13320 
 
acctacaact tgtgctaatg accctgtggg ttttacactt aaaaacacag tctgtaccgt    13380 
 
ctgcggtatg tggaaaggtt atggctgtag ttgtgatcaa ctccgcgaac ccatgcttca    13440 
 
gtcagctgat gcacaatcgt ttttaaacgg gtttgcggtg taagtgcagc ccgtcttaca    13500 
 
ccgtgcggca caggcactag tactgatgtc gtatacaggg cttttgacat ctacaatgat    13560 
 
aaagtagctg gttttgctaa attcctaaaa actaattgtt gtcgcttcca agaaaaggac    13620 
 
gaagatgaca atttaattga ttcttacttt gtagttaaga gacacacttt ctctaactac    13680 
 
caacatgaag aaacaattta taatttactt aaggattgtc cagctgttgc taaacatgac    13740 
 
ttctttaagt ttagaataga cggtgacatg gtaccacata tatcacgtca acgtcttact    13800 
 
aaatacacaa tggcagacct cgtctatgct ttaaggcatt ttgatgaagg taattgtgac    13860 
 
acattaaaag aaatacttgt cacatacaat tgttgtgatg atgattattt caataaaaag    13920 
 
gactggtatg attttgtaga aaacccagat atattacgcg tatacgccaa cttaggtgaa    13980 
 
cgtgtacgcc aagctttgtt aaaaacagta caattctgtg atgccatgcg aaatgctggt    14040 
 
attgttggtg tactgacatt agataatcaa gatctcaatg gtaactggta tgatttcggt    14100 
 
gatttcatac aaaccacgcc aggtagtgga gttcctgttg tagattctta ttattcattg    14160 
 
ttaatgccta tattaacctt gaccagggct ttaactgcag agtcacatgt tgacactgac    14220 
 
ttaacaaagc cttacattaa gtgggatttg ttaaaatatg acttcacgga agagaggtta    14280 
 
aaactctttg accgttattt taaatattgg gatcagacat accacccaaa ttgtgttaac    14340 
 
tgtttggatg acagatgcat tctgcattgt gcaaacttta atgttttatt ctctacagtg    14400 
 
ttcccaccta caagttttgg accactagtg agaaaaatat ttgttgatgg tgttccattt    14460 
 
gtagtttcaa ctggatacca cttcagagag ctaggtgttg tacataatca ggatgtaaac    14520 
 
ttacatagct ctagacttag ttttaaggaa ttacttgtgt atgctgctga ccctgctatg    14580 
 
cacgctgctt ctggtaatct attactagat aaacgcacta cgtgcttttc agtagctgca    14640 
 
cttactaaca atgttgcttt tcaaactgtc aaacccggta attttaacaa agacttctat    14700 
 
gactttgctg tgtctaaggg tttctttaag gaaggaagtt ctgttgaatt aaaacacttc    14760 
 
ttctttgctc aggatggtaa tgctgctatc agcgattatg actactatcg ttataatcta    14820 
 
ccaacaatgt gtgatatcag acaactacta tttgtagttg aagttgttga taagtacttt    14880 
 
gattgttacg atggtggctg tattaatgct aaccaagtca tcgtcaacaa cctagacaaa    14940 
 
tcagctggtt ttccatttaa taaatggggt aaggctagac tttattatga ttcaatgagt    15000 
 
tatgaggatc aagatgcact tttcgcatat acaaaacgta atgtcatccc tactataact    15060 
 
caaatgaatc ttaagtatgc cattagtgca aagaatagag ctcgcaccgt agctggtgtc    15120 
 
tctatctgta gtactatgac caatagacag tttcatcaaa aattattgaa atcaatagcc    15180 
 
gccactagag gagctactgt agtaattgga acaagcaaat tctatggtgg ttggcacaac    15240 
 
atgttaaaaa ctgtttatag tgatgtagaa aaccctcacc ttatgggttg ggattatcct    15300 
 
aaatgtgata gagccatgcc taacatgctt agaattatgg cctcacttgt tcttgctcgc    15360 
 
aaacatacaa cgtgttgtag cttgtcacac cgtttctata gattagctaa tgagtgtgct    15420 
 
caagtattga gtgaaatggt catgtgtggc ggttcactat atgttaaacc aggtggaacc    15480 
 
tcatcaggag atgccacaac tgcttatgct aatagtgttt ttaacatttg tcaagctgtc    15540 
 
acggccaatg ttaatgcact tttatctact gatggtaaca aaattgccga taagtatgtc    15600 
 
cgcaatttac aacacagact ttatgagtgt ctctatagaa atagagatgt tgacacagac    15660 
 
tttgtgaatg agttttacgc atatttgcgt aaacatttct caatgatgat actctctgac    15720 
 
gatgctgttg tgtgtttcaa tagcacttat gcatctcaag gtctagtggc tagcataaag    15780 
 
aactttaagt cagttcttta ttatcaaaac aatgttttta tgtctgaagc aaaatgttgg    15840 
 
actgagactg accttactaa aggacctcat gaattttgct ctcaacatac aatgctagtt    15900 
 
aaacagggtg atgattatgt gtaccttcct tacccagatc catcaagaat cctaggggcc    15960 
 
ggctgttttg tagatgatat cgtaaaaaca gatggtacac ttatgattga acggttcgtg    16020 
 
tctttagcta tagatgctta cccacttact aaacatccta atcaggagta tgctgatgtc    16080 
 
tttcatttgt acttacaata cataagaaag ctacatgatg agttaacagg acacatgtta    16140 
 
gacatgtatt ctgttatgct tactaatgat aacacttcaa ggtattggga acctgagttt    16200 
 
tatgaggcta tgtacacacc gcatacagtc ttacaggctg ttggggcttg tgttctttgc    16260 
 
aattcacaga cttcattaag atgtggtgct tgcatacgta gaccattctt atgttgtaaa    16320 
 
tgctgttacg accatgtcat atcaacatca cataaattag tcttgtctgt taatccgtat    16380 
 
gtttgcaatg ctccaggttg tgatgtcaca gatgtgactc aactttactt aggaggtatg    16440 
 
agctattatt gtaaatcaca taaaccaccc attagttttc cattgtgtgc taatggacaa    16500 
 
gtttttggtt tatataaaaa tacatgtgtt ggtagcgata atgttactga ctttaatgca    16560 
 
attgcaacat gtgactggac aaatgctggt gattacattt tagctaacac ctgtactgaa    16620 
 
agactcaagc tttttgcagc agaaacgctc aaagctactg aggagacatt taaactgtct    16680 
 
tatggtattg ctactgtacg tgaagtgctg tctgacagag aattacatct ttcatgggaa    16740 
 
gttggtaaac ctagaccacc acttaaccga aattatgtct ttactggtta tcgtgtaact    16800 
 
aaaaacagta aagtacaaat aggagagtac acctttgaaa aaggtgacta tggtgatgct    16860 
 
gttgtttacc gaggtacaac aacttacaaa ttaaatgttg gtgattattt tgtgctgaca    16920 
 
tcacatacag taatgccatt aagtgcacct acactagtgc cacaagagca ctatgttaga    16980 
 
attactggct tatacccaac actcaatatc tcagatgagt tttctagcaa tgttgcaaat    17040 
 
tatcaaaagg ttggtatgca aaagtattct acactccagg gaccacctgg tactggtaag    17100 
 
agtcattttg ctattggcct agctctctac tacccttctg ctcgcatagt gtatacagct    17160 
 
tgctctcatg ccgctgttga tgcactatgt gagaaggcat taaaatattt gcctatagat    17220 
 
aaatgtagta gaattatacc tgcacgtgct cgtgtagagt gttttgataa attcaaagtg    17280 
 
aattcaacat tagaacagta tgtcttttgt actgtaaatg cattgcctga gacgacagca    17340 
 
gatatagttg tctttgatga aatttcaatg gccacaaatt atgatttgag tgttgtcaat    17400 
 
gccagattac gtgctaagca ctatgtgtac attggcgacc ctgctcaatt acctgcacca    17460 
 
cgcacattgc taactaaggg cacactagaa ccagaatatt tcaattcagt gtgtagactt    17520 
 
atgaaaacta taggtccaga catgttcctc ggaacttgtc ggcgttgtcc tgctgaaatt    17580 
 
gttgacactg tgagtgcttt ggtttatgat aataagctta aagcacataa agacaaatca    17640 
 
gctcaatgct ttaaaatgtt ttataagggt gttatcacgc atgatgtttc atctgcaatt    17700 
 
aacaggccac aaataggcgt ggtaagagaa ttccttacac gtaaccctgc ttggagaaaa    17760 
 
gctgtcttta tttcacctta taattcacag aatgctgtag cctcaaagat tttgggacta    17820 
 
ccaactcaaa ctgttgattc atcacagggc tcagaatatg actatgtcat attcactcaa    17880 
 
accactgaaa cagctcactc ttgtaatgta aacagattta atgttgctat taccagagca    17940 
 
aaagtaggca tactttgcat aatgtctgat agagaccttt atgacaagtt gcaatttaca    18000 
 
agtcttgaaa ttccacgtag gaatgtggca actttacaag ctgaaaatgt aacaggactc    18060 
 
tttaaagatt gtagtaaggt aatcactggg ttacatccta cacaggcacc tacacacctc    18120 
 
agtgttgaca ctaaattcaa aactgaaggt ttatgtgttg acatacctgg catacctaag    18180 
 
gacatgacct atagaagact catctctatg atgggtttta aaatgaatta tcaagttaat    18240 
 
ggttacccta acatgtttat cacccgcgaa gaagctataa gacatgtacg tgcatggatt    18300 
 
ggcttcgatg tcgaggggtg tcatgctact agagaagctg ttggtaccaa tttaccttta    18360 
 
cagctaggtt tttctacagg tgttaaccta gttgctgtac ctacaggtta tgttgataca    18420 
 
cctaataata cagatttttc cagagttagt gctaaaccac cgcctggaga tcaatttaaa    18480 
 
cacctcatac cacttatgta caaaggactt ccttggaatg tagtgcgtat aaagattgta    18540 
 
caaatgttaa gtgacacact taaaaatctc tctgacagag tcgtatttgt cttatgggca    18600 
 
catggctttg agttgacatc tatgaagtat tttgtgaaaa taggacctga gcgcacctgt    18660 
 
tgtctatgtg atagacgtgc cacatgcttt tccactgctt cagacactta tgcctgttgg    18720 
 
catcattcta ttggatttga ttacgtctat aatccgttta tgattgatgt tcaacaatgg    18780 
 
ggttttacag gtaacctaca aagcaaccat gatctgtatt gtcaagtcca tggtaatgca    18840 
 
catgtagcta gttgtgatgc aatcatgact aggtgtctag ctgtccacga gtgctttgtt    18900 
 
aagcgtgttg actggactat tgaatatcct ataattggtg atgaactgaa gattaatgcg    18960 
 
gcttgtagaa aggttcaaca catggttgtt aaagctgcat tattagcaga caaattccca    19020 
 
gttcttcacg acattggtaa ccctaaagct attaagtgtg tacctcaagc tgatgtagaa    19080 
 
tggaagttct atgatgcaca gccttgtagt gacaaagctt ataaaataga agaattattc    19140 
 
tattcttatg ccacacattc tgacaaattc acagatggtg tatgcctatt ttggaattgc    19200 
 
aatgtcgata gatatcctgc taattccatt gtttgtagat ttgacactag agtgctatct    19260 
 
aaccttaact tgcctggttg tgatggtggc agtttgtatg taaataaaca tgcattccac    19320 
 
acaccagctt ttgataaaag tgcttttgtt aatttaaaac aattaccatt tttctattac    19380 
 
tctgacagtc catgtgagtc tcatggaaaa caagtagtgt cagatataga ttatgtacca    19440 
 
ctaaagtctg ctacgtgtat aacacgttgc aatttaggtg gtgctgtctg tagacatcat    19500 
 
gctaatgagt acagattgta tctcgatgct tataacatga tgatctcagc tggctttagc    19560 
 
ttgtgggttt acaaacaatt tgatacttat aacctctgga acacttttac aagacttcag    19620 
 
agtttagaaa atgtggcttt taatgttgta aataagggac actttgatgg acaacagggt    19680 
 
gaagtaccag tttctatcat taataacact gtttacacaa aagttgatgg tgttgatgta    19740 
 
gaattgtttg aaaataaaac aacattacct gttaatgtag catttgagct ttgggctaag    19800 
 
cgcaacatta aaccagtacc agaggtgaaa atactcaata atttgggtgt ggacattgct    19860 
 
gctaatactg tgatctggga ctacaaaaga gatgctccag cacatatatc tactattggt    19920 
 
gtttgttcta tgactgacat agccaagaaa ccaactgaaa cgatttgtgc accactcact    19980 
 
gtcttttttg atggtagagt tgatggtcaa gtagacttat ttagaaatgc ccgtaatggt    20040 
 
gttcttatta cagaaggtag tgttaaaggt ttacaaccat ctgtaggtcc caaacaagct    20100 
 
agtcttaatg gagtcacatt aattggagaa gccgtaaaaa cacagttcaa ttattataag    20160 
 
aaagttgatg gtgttgtcca acaattacct gaaacttact ttactcagag tagaaattta    20220 
 
caagaattta aacccaggag tcaaatggaa attgatttct tagaattagc tatggatgaa    20280 
 
ttcattgaac ggtataaatt agaaggctat gccttcgaac atatcgttta tggagatttt    20340 
 
agtcatagtc agttaggtgg tttacatcta ctgattggac tagctaaacg ttttaaggaa    20400 
 
tcaccttttg aattagaaga ttttattcct atggacagta cagttaaaaa ctatttcata    20460 
 
acagatgcgc aaacaggttc atctaagtgt gtgtgttctg ttattgattt attacttgat    20520 
 
gattttgttg aaataataaa atcccaagat ttatctgtag tttctaaggt tgtcaaagtg    20580 
 
actattgact atacagaaat ttcatttatg ctttggtgta aagatggcca tgtagaaaca    20640 
 
ttttacccaa aattacaatc tagtcaagcg tggcaaccgg gtgttgctat gcctaatctt    20700 
 
tacaaaatgc aaagaatgct attagaaaag tgtgaccttc aaaattatgg tgatagtgca    20760 
 
acattaccta aaggcataat gatgaatgtc gcaaaatata ctcaactgtg tcaatattta    20820 
 
aacacattaa cattagctgt accctataat atgagagtta tacattttgg tgctggttct    20880 
 
gataaaggag ttgcaccagg tacagctgtt ttaagacagt ggttgcctac gggtacgctg    20940 
 
cttgtcgatt cagatcttaa tgactttgtc tctgatgcag attcaacttt gattggtgat    21000 
 
tgtgcaactg tacatacagc taataaatgg gatctcatta ttagtgatat gtacgaccct    21060 
 
aagactaaaa atgttacaaa agaaaatgac tctaaagagg gttttttcac ttacatttgt    21120 
 
gggtttatac aacaaaagct agctcttgga ggttccgtgg ctataaagat aacagaacat    21180 
 
tcttggaatg ctgatcttta taagctcatg ggacacttcg catggtggac agcctttgtt    21240 
 
actaatgtga atgcgtcatc atctgaagca tttttaattg gatgtaatta tcttggcaaa    21300 
 
ccacgcgaac aaatagatgg ttatgtcatg catgcaaatt acatattttg gaggaataca    21360 
 
aatccaattc agttgtcttc ctattcttta tttgacatga gtaaatttcc ccttaaatta    21420 
 
aggggtactg ctgttatgtc tttaaaagaa ggtcaaatca atgatatgat tttatctctt    21480 
 
cttagtaaag gtagacttat aattagagaa aacaacagag ttgttatttc tagtgatgtt    21540 
 
cttgttaaca actaaacgaa caatgtttgt ttttcttgtt ttattgccac tagtctctag    21600 
 
tcagtgtgtt aatcttacaa ccagaactca attaccccct gcatacacta attctttcac    21660 
 
acgtggtgtt tattaccctg acaaagtttt cagatcctca gttttacatt caactcagga    21720 
 
cttgttctta cctttctttt ccaatgttac ttggttccat gctatacatg tctctgggac    21780 
 
caatggtact aagaggtttg ataaccctgt cctaccattt aatgatggtg tttattttgc    21840 
 
ttccactgag aagtctaaca taataagagg ctggattttt ggtactactt tagattcgaa    21900 
 
gacccagtcc ctacttattg ttaataacgc tactaatgtt gttattaaag tctgtgaatt    21960 
 
tcaattttgt aatgatccat ttttgggtgt ttattaccac aaaaacaaca aaagttggat    22020 
 
ggaaagtgag ttcagagttt attctagtgc gaataattgc acttttgaat atgtctctca    22080 
 
gccttttctt atggaccttg aaggaaaaca gggtaatttc aaaaatctta gggaatttgt    22140 
 
gtttaagaat attgatggtt attttaaaat atattctaag cacacgccta ttaatttagt    22200 
 
gcgtgatctc cctcagggtt tttcggcttt agaaccattg gtagatttgc caataggtat    22260 
 
taacatcact aggtttcaaa ctttacttgc tttacataga agttatttga ctcctggtga    22320 
 
ttcttcttca ggttggacag ctggtgctgc agcttattat gtgggttatc ttcaacctag    22380 
 
gacttttcta ttaaaatata atgaaaatgg aaccattaca gatgctgtag actgtgcact    22440 
 
tgaccctctc tcagaaacaa agtgtacgtt gaaatccttc actgtagaaa aaggaatcta    22500 
 
tcaaacttct aactttagag tccaaccaac agaatctatt gttagatttc ctaatattac    22560 
 
aaacttgtgc ccttttggtg aagtttttaa cgccaccaga tttgcatctg tttatgcttg    22620 
 
gaacaggaag agaatcagca actgtgttgc tgattattct gtcctatata attccgcatc    22680 
 
attttccact tttaagtgtt atggagtgtc tcctactaaa ttaaatgatc tctgctttac    22740 
 
taatgtctat gcagattcat ttgtaattag aggtgatgaa gtcagacaaa tcgctccagg    22800 
 
gcaaactgga aagattgctg attataatta taaattacca gatgatttta caggctgcgt    22860 
 
tatagcttgg aattctaaca atcttgattc taaggttggt ggtaattata attacctgta    22920 
 
tagattgttt aggaagtcta atctcaaacc ttttgagaga gatatttcaa ctgaaatcta    22980 
 
tcaggccggt agcacacctt gtaatggtgt tgaaggtttt aattgttact ttcctttaca    23040 
 
atcatatggt ttccaaccca ctaatggtgt tggttaccaa ccatacagag tagtagtact    23100 
 
ttcttttgaa cttctacatg caccagcaac tgtttgtgga cctaaaaagt ctactaattt    23160 
 
ggttaaaaac aaatgtgtca atttcaactt caatggttta acaggcacag gtgttcttac    23220 
 
tgagtctaac aaaaagtttc tgcctttcca acaatttggc agagacattg ctgacactac    23280 
 
tgatgctgtc cgtgatccac agacacttga gattcttgac attacaccat gttcttttgg    23340 
 
tggtgtcagt gttataacac caggaacaaa tacttctaac caggttgctg ttctttatca    23400 
 
ggatgttaac tgcacagaag tccctgttgc tattcatgca gatcaactta ctcctacttg    23460 
 
gcgtgtttat tctacaggtt ctaatgtttt tcaaacacgt gcaggctgtt taataggggc    23520 
 
tgaacatgtc aacaactcat atgagtgtga catacccatt ggtgcaggta tatgcgctag    23580 
 
ttatcagact cagactaatt ctcctcggcg ggcacgtagt gtagctagtc aatccatcat    23640 
 
tgcctacact atgtcacttg gtgcagaaaa ttcagttgct tactctaata actctattgc    23700 
 
catacccaca aattttacta ttagtgttac cacagaaatt ctaccagtgt ctatgaccaa    23760 
 
gacatcagta gattgtacaa tgtacatttg tggtgattca actgaatgca gcaatctttt    23820 
 
gttgcaatat ggcagttttt gtacacaatt aaaccgtgct ttaactggaa tagctgttga    23880 
 
acaagacaaa aacacccaag aagtttttgc acaagtcaaa caaatttaca aaacaccacc    23940 
 
aattaaagat tttggtggtt ttaatttttc acaaatatta ccagatccat caaaaccaag    24000 
 
caagaggtca tttattgaag atctactttt caacaaagtg acacttgcag atgctggctt    24060 
 
catcaaacaa tatggtgatt gccttggtga tattgctgct agagacctca tttgtgcaca    24120 
 
aaagtttaac ggccttactg ttttgccacc tttgctcaca gatgaaatga ttgctcaata    24180 
 
cacttctgca ctgttagcgg gtacaatcac ttctggttgg acctttggtg caggtgctgc    24240 
 
attacaaata ccatttgcta tgcaaatggc ttataggttt aatggtattg gagttacaca    24300 
 
gaatgttctc tatgagaacc aaaaattgat tgccaaccaa tttaatagtg ctattggcaa    24360 
 
aattcaagac tcactttctt ccacagcaag tgcacttgga aaacttcaag atgtggtcaa    24420 
 
ccaaaatgca caagctttaa acacgcttgt taaacaactt agctccaatt ttggtgcaat    24480 
 
ttcaagtgtt ttaaatgata tcctttcacg tcttgacaaa gttgaggctg aagtgcaaat    24540 
 
tgataggttg atcacaggca gacttcaaag tttgcagaca tatgtgactc aacaattaat    24600 
 
tagagctgca gaaatcagag cttctgctaa tcttgctgct actaaaatgt cagagtgtgt    24660 
 
acttggacaa tcaaaaagag ttgatttttg tggaaagggc tatcatctta tgtccttccc    24720 
 
tcagtcagca cctcatggtg tagtcttctt gcatgtgact tatgtccctg cacaagaaaa    24780 
 
gaacttcaca actgctcctg ccatttgtca tgatggaaaa gcacactttc ctcgtgaagg    24840 
 
tgtctttgtt tcaaatggca cacactggtt tgtaacacaa aggaattttt atgaaccaca    24900 
 
aatcattact acagacaaca catttgtgtc tggtaactgt gatgttgtaa taggaattgt    24960 
 
caacaacaca gtttatgatc ctttgcaacc tgaattagac tcattcaagg aggagttaga    25020 
 
taaatatttt aagaatcata catcaccaga tgttgattta ggtgacatct ctggcattaa    25080 
 
tgcttcagtt gtaaacattc aaaaagaaat tgaccgcctc aatgaggttg ccaagaattt    25140 
 
aaatgaatct ctcatcgatc tccaagaact tggaaagtat gagcagtata taaaatggcc    25200 
 
atggtacatt tggctaggtt ttatagctgg cttgattgcc atagtaatgg tgacaattat    25260 
 
gctttgctgt atgaccagtt gctgtagttg tctcaagggc tgttgttctt gtggatcctg    25320 
 
ctgcaaattt gatgaagacg actctgagcc agtgctcaaa ggagtcaaat tacattacac    25380 
 
ataaacgaac ttatggattt gtttatgaga atcttcacaa ttggaactgt aactttgaag    25440 
 
caaggtgaaa tcaaggatgc tactccttca gattttgttc gcgctactgc aacgataccg    25500 
 
atacaagcct cactcccttt cggatggctt attgttggcg ttgcacttct tgctgttttt    25560 
 
cagagcgctt ccaaaatcat aaccctcaaa aagagatggc aactagcact ctccaagggt    25620 
 
gttcactttg tttgcaactt gctgttgttg tttgtaacag tttactcaca ccttttgctc    25680 
 
gttgctgctg gccttgaagc cccttttctc tatctttatg ctttagtcta cttcttgcag    25740 
 
agtataaact ttgtaagaat aataatgagg ctttggcttt gctggaaatg ccgttccaaa    25800 
 
aacccattac tttatgatgc caactatttt ctttgctggc atactaattg ttacgactat    25860 
 
tgtatacctt acaatagtgt aacttcttca attgtcatta cttcaggtga tggcacaaca    25920 
 
agtcctattt ctgaacatga ctaccagatt ggtggttata ctgaaaaatg ggaatctgga    25980 
 
gtaaaagact gtgttgtatt acacagttac ttcacttcag actattacca gctgtactca    26040 
 
actcaattga gtacagacac tggtgttgaa catgttacct tcttcatcta caataaaatt    26100 
 
gttgatgagc ctgaagaaca tgtccaaatt cacacaatcg acggttcatc cggagttgtt    26160 
 
aatccagtaa tggaaccaat ttatgatgaa ccgacgacga ctactagcgt gcctttgtaa    26220 
 
gcacaagctg atgagtacga acttatgtac tcattcgttt cggaagagac aggtacgtta    26280 
 
atagttaata gcgtacttct ttttcttgct ttcgtggtat tcttgctagt tacactagcc    26340 
 
atccttactg cgcttcgatt gtgtgcgtac tgctgcaata ttgttaacgt gagtcttgta    26400 
 
aaaccttctt tttacgttta ctctcgtgtt aaaaatctga attcttctag agttcctgat    26460 
 
cttctggtct aaacgaacta aatattatat tagtttttct gtttggaact ttaattttag    26520 
 
ccatggcaga ttccaacggt actattaccg ttgaagagct taaaaagctc cttgaacaat    26580 
 
ggaacctagt aataggtttc ctattcctta catggatttg tcttctacaa tttgcctatg    26640 
 
ccaacaggaa taggtttttg tatataatta agttaatttt cctctggctg ttatggccag    26700 
 
taactttagc ttgttttgtg cttgctgctg tttacagaat aaattggatc accggtggaa    26760 
 
ttgctatcgc aatggcttgt cttgtaggct tgatgtggct cagctacttc attgcttctt    26820 
 
tcagactgtt tgcgcgtacg cgttccatgt ggtcattcaa tccagaaact aacattcttc    26880 
 
tcaacgtgcc actccatggc actattctga ccagaccgct tctagaaagt gaactcgtaa    26940 
 
tcggagctgt gatccttcgt ggacatcttc gtattgctgg acaccatcta ggacgctgtg    27000 
 
acatcaagga cctgcctaaa gaaatcactg ttgctacatc acgaacgctt tcttattaca    27060 
 
aattgggagc ttcgcagcgt gtagcaggtg actcaggttt tgctgcatac agtcgctaca    27120 
 
ggattggcaa ctataaatta aacacagacc attccagtag cagtgacaat attgctttgc    27180 
 
ttgtacagta agtgacaaca gatgtttcat ctcgttgact ttcaggttac tatagcagag    27240 
 
atattactaa ttattatgag gacttttaaa gtttccattt ggaatcttga ttacatcata    27300 
 
aacctcataa ttaaaaattt atctaagtca ctaactgaga ataaatattc tcaattagat    27360 
 
gaagagcaac caatggagat tgattaaacg aacatgaaaa ttattctttt cttggcactg    27420 
 
ataacactcg ctacttgtga gctttatcac taccaagagt gtgttagagg tacaacagta    27480 
 
cttttaaaag aaccttgctc ttctggaaca tacgagggca attcaccatt tcatcctcta    27540 
 
gctgataaca aatttgcact gacttgcttt agcactcaat ttgcttttgc ttgtcctgac    27600 
 
ggcgtaaaac acgtctatca gttacgtgcc agatcagttt cacctaaact gttcatcaga    27660 
 
caagaggaag ttcaagaact ttactctcca atttttctta ttgttgcggc aatagtgttt    27720 
 
ataacacttt gcttcacact caaaagaaag acagaatgat tgaactttca ttaattgact    27780 
 
tctatttgtg ctttttagcc tttctgctat tccttgtttt aattatgctt attatctttt    27840 
 
ggttctcact tgaactgcaa gatcataatg aaacttgtca cgcctaaacg aacatgaaat    27900 
 
ttcttgtttt cttaggaatc atcacaactg tagctgcatt tcaccaagaa tgtagtttac    27960 
 
agtcatgtac tcaacatcaa ccatatgtag ttgatgaccc gtgtcctatt cacttctatt    28020 
 
ctaaatggta tattagagta ggagctagaa aatcagcacc tttaattgaa ttgtgcgtgg    28080 
 
atgaggctgg ttctaaatca cccattcagt acatcgatat cggtaattat acagtttcct    28140 
 
gtttaccttt tacaattaat tgccaggaac ctaaattggg tagtcttgta gtgcgttgtt    28200 
 
cgttctatga agacttttta gagtatcatg acgttcgtgt tgttttagat ttcatctaaa    28260 
 
cgaacaaact aaaatgtctg ataatggacc ccaaaatcag cgaaatgcac cccgcattac    28320 
 
gtttggtgga ccctcagatt caactggcag taaccagaat ggagaacgca gtggggcgcg    28380 
 
atcaaaacaa cgtcggcccc aaggtttacc caataatact gcgtcttggt tcaccgctct    28440 
 
cactcaacat ggcaaggaag accttaaatt ccctcgagga caaggcgttc caattaacac    28500 
 
caatagcagt ccagatgacc aaattggcta ctaccgaaga gctaccagac gaattcgtgg    28560 
 
tggtgacggt aaaatgaaag atctcagtcc aagatggtat ttctactacc taggaactgg    28620 
 
gccagaagct ggacttccct atggtgctaa caaagacggc atcatatggg ttgcaactga    28680 
 
gggagccttg aatacaccaa aagatcacat tggcacccgc aatcctgcta acaatgctgc    28740 
 
aatcgtgcta caacttcctc aaggaacaac attgccaaaa ggcttctacg cagaagggag    28800 
 
cagaggcggc agtcaagcct cttctcgttc ctcatcacgt agtcgcaaca gttcaagaaa    28860 
 
ttcaactcca ggcagcagta ggggaacttc tcctgctaga atggctggca atggcggtga    28920 
 
tgctgctctt gctttgctgc tgcttgacag attgaaccag cttgagagca aaatgtctgg    28980 
 
taaaggccaa caacaacaag gccaaactgt cactaagaaa tctgctgctg aggcttctaa    29040 
 
gaagcctcgg caaaaacgta ctgccactaa agcatacaat gtaacacaag ctttcggcag    29100 
 
acgtggtcca gaacaaaccc aaggaaattt tggggaccag gaactaatca gacaaggaac    29160 
 
tgattacaaa cattggccgc aaattgcaca atttgccccc agcgcttcag cgttcttcgg    29220 
 
aatgtcgcgc attggcatgg aagtcacacc ttcgggaacg tggttgacct acacaggtgc    29280 
 
catcaaattg gatgacaaag atccaaattt caaagatcaa gtcattttgc tgaataagca    29340 
 
tattgacgca tacaaaacat tcccaccaac agagcctaaa aaggacaaaa agaagaaggc    29400 
 
tgatgaaact caagccttac cgcagagaca gaagaaacag caaactgtga ctcttcttcc    29460 
 
tgctgcagat ttggatgatt tctccaaaca attgcaacaa tccatgagca gtgctgactc    29520 
 
aactcaggcc taaactcatg cagaccacac aaggcagatg ggctatataa acgttttcgc    29580 
 
ttttccgttt acgatatata gtctactctt gtgcagaatg aattctcgta actacatagc    29640 
 
acaagtagat gtagttaact ttaatctcac atagcaatct ttaatcagtg tgtaacatta    29700 
 
gggaggactt gaaagagcca ccacattttc accgaggcca cgcggagtac gatcgagtgt    29760 
 
acagtgaaca atgctaggga gagctgccta tatggaagag ccctaatgtg taaaattaat    29820 
 
tttagtagtg ctatccccat gtgattttaa tagcttctta ggagaatgac aaaaaaaaaa    29880 
 
aaaaaaaaaa aaaaaaaaaa aaa                                            29903 
 
 
<210>  353 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  spike protein (wild-type) 
 
<400>  353 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  354 
<211>  214 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  receptor binding domain (wild-type) 
 
<400>  354 
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
  1               5                  10                  15      
 
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
             20                  25                  30          
 
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
         35                  40                  45              
 
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
     50                  55                  60                  
 
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
 65                  70                  75                  80  
 
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                 85                  90                  95      
 
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110          
 
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125              
 
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                  
 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160  
 
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175      
 
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190          
 
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205              
 
Pro Lys Lys Ser Thr Asn 
    210                  
 
<210>  355 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  V483A variant 
 
<400>  355 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Ala Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  356 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  V483I variant 
 
<400>  356 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Ile Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  357 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  L455I/F456V  variant 
 
<400>  357 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Ile Val Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  358 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  G476S variant 
 
<400>  358 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Ser Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  359 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  S494P variant 
 
<400>  359 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Pro Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  360 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  N439K variant 
 
<400>  360 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Lys Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
<210>  361 
<211>  1273 
<212>  PRT 
<213>  Severe acute respiratory syndrome coronavirus 2 
 
<220>   
<223>  D614G variant 
 
<400>  361 
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
  1               5                  10                  15      
 
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
             20                  25                  30          
 
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
         35                  40                  45              
 
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
     50                  55                  60                  
 
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
 65                  70                  75                  80  
 
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                 85                  90                  95      
 
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110          
 
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125              
 
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                  
 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160  
 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175      
 
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190          
 
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205              
 
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                  
 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240  
 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255      
 
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270          
 
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285              
 
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                  
 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320  
 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335      
 
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350          
 
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365              
 
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                  
 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400  
 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415      
 
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430          
 
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445              
 
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                  
 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480  
 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495      
 
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510          
 
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525              
 
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                  
 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560  
 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575      
 
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590          
 
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605              
 
Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                  
 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640  
 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655      
 
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670          
 
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685              
 
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                  
 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720  
 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735      
 
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750          
 
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765              
 
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                  
 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800  
 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815      
 
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830          
 
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845              
 
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                  
 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880  
 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895      
 
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910          
 
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925              
 
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                  
 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960  
 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975      
 
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990          
 
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                 1005              
 
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                 1015                 1020                  
 
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                 1030                 1035                 1040  
 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                 1050                 1055      
 
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                 1065                 1070          
 
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                 1080                 1085              
 
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                 1095                 1100                  
 
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                 1110                 1115                 1120  
 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                 1130                 1135      
 
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                 1145                 1150          
 
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                 1160                 1165              
 
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                 1175                 1180                  
 
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                 1190                 1195                 1200  
 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                 1210                 1215      
 
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                 1225                 1230          
 
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                 1240                 1245              
 
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                 1255                 1260                  
 
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                 1270              
 
