                         SEQUENCE LISTING

<110>  SynVaccine Ltd.
 
<120>  MODIFIED GENOMES AND USE THEREOF

<130>  SYV-P-006-PCT

<150>  63/008,050
<151>  2020-04-10

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  903
<212>  PRT
<213>  Zika Virus

<400>  1

Gly Gly Gly Thr Gly Glu Thr Leu Gly Glu Lys Trp Lys Ala Arg Leu 
1               5                   10                  15      


Asn Gln Met Ser Ala Leu Glu Phe Tyr Ser Tyr Lys Lys Ser Gly Ile 
            20                  25                  30          


Thr Glu Val Cys Arg Glu Glu Ala Arg Arg Ala Leu Lys Asp Gly Val 
        35                  40                  45              


Ala Thr Gly Gly His Ala Val Ser Arg Gly Ser Ala Lys Leu Arg Trp 
    50                  55                  60                  


Leu Val Glu Arg Gly Tyr Leu Gln Pro His Gly Lys Val Ile Asp Leu 
65                  70                  75                  80  


Gly Cys Gly Arg Gly Gly Trp Ser Tyr Tyr Ala Ala Thr Ile Arg Lys 
                85                  90                  95      


Val Gln Glu Val Lys Gly Tyr Thr Lys Gly Gly Pro Gly His Glu Glu 
            100                 105                 110         


Pro Met Leu Val Gln Ser Tyr Gly Trp Asn Ile Val Arg Leu Lys Ser 
        115                 120                 125             


Gly Val Asp Val Phe His Met Ala Ala Glu Pro Cys Asp Thr Leu Leu 
    130                 135                 140                 


Cys Asp Ile Gly Glu Ser Ser Ser Ser Pro Glu Val Glu Glu Ala Arg 
145                 150                 155                 160 


Thr Leu Arg Val Leu Ser Met Val Gly Asp Trp Leu Glu Lys Arg Pro 
                165                 170                 175     


Gly Ala Phe Cys Ile Lys Val Leu Cys Pro Tyr Thr Ser Thr Met Met 
            180                 185                 190         


Glu Thr Leu Glu Arg Leu Gln Arg Arg Tyr Gly Gly Gly Leu Val Arg 
        195                 200                 205             


Val Pro Leu Ser Arg Asn Ser Thr His Glu Met Tyr Trp Val Ser Gly 
    210                 215                 220                 


Ala Lys Ser Asn Thr Ile Lys Ser Val Ser Thr Thr Ser Gln Leu Leu 
225                 230                 235                 240 


Leu Gly Arg Met Asp Gly Pro Arg Arg Pro Val Lys Tyr Glu Glu Asp 
                245                 250                 255     


Val Asn Leu Gly Ser Gly Thr Arg Ala Val Val Ser Cys Ala Glu Ala 
            260                 265                 270         


Pro Asn Met Lys Ile Ile Gly Asn Arg Ile Glu Arg Ile Arg Ser Glu 
        275                 280                 285             


His Ala Glu Thr Trp Phe Phe Asp Glu Asn His Pro Tyr Arg Thr Trp 
    290                 295                 300                 


Ala Tyr His Gly Ser Tyr Glu Ala Pro Thr Gln Gly Ser Ala Ser Ser 
305                 310                 315                 320 


Leu Val Asn Gly Val Val Arg Leu Leu Ser Lys Pro Trp Asp Val Val 
                325                 330                 335     


Thr Gly Val Thr Gly Ile Ala Met Thr Asp Thr Thr Pro Tyr Gly Gln 
            340                 345                 350         


Gln Arg Val Phe Lys Glu Lys Val Asp Thr Arg Val Pro Asp Pro Gln 
        355                 360                 365             


Glu Gly Thr Arg Gln Val Met Ser Met Val Ser Ser Trp Leu Trp Lys 
    370                 375                 380                 


Glu Leu Gly Lys His Lys Arg Pro Arg Val Cys Thr Lys Glu Glu Phe 
385                 390                 395                 400 


Ile Asn Lys Val Arg Ser Asn Ala Ala Leu Gly Ala Ile Phe Glu Glu 
                405                 410                 415     


Glu Lys Glu Trp Lys Thr Ala Val Glu Ala Val Asn Asp Pro Arg Phe 
            420                 425                 430         


Trp Ala Leu Val Asp Lys Glu Arg Glu Tyr His Leu Arg Gly Glu Cys 
        435                 440                 445             


Gln Ser Cys Val Tyr Asn Met Met Gly Lys Arg Glu Lys Lys Gln Gly 
    450                 455                 460                 


Glu Phe Gly Lys Ala Lys Gly Ser Arg Ala Ile Trp Tyr Met Trp Leu 
465                 470                 475                 480 


Gly Ala Arg Phe Leu Glu Phe Glu Ala Leu Gly Phe Leu Asn Glu Asp 
                485                 490                 495     


His Trp Met Gly Arg Glu Asn Ser Gly Gly Gly Val Glu Gly Leu Gly 
            500                 505                 510         


Leu Gln Arg Leu Gly Tyr Val Leu Glu Glu Met Ser Arg Ile Pro Gly 
        515                 520                 525             


Gly Arg Met Tyr Ala Asp Asp Thr Ala Gly Trp Asp Thr Arg Ile Ser 
    530                 535                 540                 


Arg Phe Asp Leu Glu Asn Glu Ala Leu Ile Thr Asn Gln Met Glu Lys 
545                 550                 555                 560 


Gly His Arg Ala Leu Ala Leu Ala Ile Ile Lys Tyr Thr Tyr Gln Asn 
                565                 570                 575     


Lys Val Val Lys Val Leu Arg Pro Ala Glu Lys Gly Lys Thr Val Met 
            580                 585                 590         


Asp Ile Ile Ser Arg Gln Asp Gln Arg Gly Ser Gly Gln Val Val Thr 
        595                 600                 605             


Tyr Ala Leu Asn Thr Phe Thr Asn Leu Val Val Gln Leu Ile Arg Asn 
    610                 615                 620                 


Met Glu Ala Glu Glu Val Leu Glu Met Gln Asp Leu Trp Leu Leu Arg 
625                 630                 635                 640 


Arg Pro Glu Lys Val Thr Asn Trp Leu Gln Ser Asn Gly Trp Asp Arg 
                645                 650                 655     


Leu Lys Arg Met Ala Val Ser Gly Asp Asp Cys Val Val Lys Pro Ile 
            660                 665                 670         


Asp Asp Arg Phe Ala His Ala Leu Arg Phe Leu Asn Asp Met Gly Lys 
        675                 680                 685             


Val Arg Lys Asp Thr Gln Glu Trp Lys Pro Ser Thr Gly Trp Asp Asn 
    690                 695                 700                 


Trp Glu Glu Val Pro Phe Cys Ser His His Phe Asn Lys Leu His Leu 
705                 710                 715                 720 


Lys Asp Gly Arg Ser Ile Val Val Pro Cys Arg His Gln Asp Glu Leu 
                725                 730                 735     


Ile Gly Arg Ala Arg Val Ser Pro Gly Ala Gly Trp Ser Ile Arg Glu 
            740                 745                 750         


Thr Ala Cys Leu Ala Lys Ser Tyr Ala Gln Met Trp Gln Leu Leu Tyr 
        755                 760                 765             


Phe His Arg Arg Asp Leu Arg Leu Met Ala Asn Ala Ile Cys Ser Ser 
    770                 775                 780                 


Val Pro Val Asp Trp Val Pro Thr Gly Arg Thr Thr Trp Ser Ile His 
785                 790                 795                 800 


Gly Lys Gly Glu Trp Met Thr Thr Glu Asp Met Leu Val Val Trp Asn 
                805                 810                 815     


Arg Val Trp Ile Glu Glu Asn Asp His Met Glu Asp Lys Thr Pro Val 
            820                 825                 830         


Thr Lys Trp Thr Asp Ile Pro Tyr Leu Gly Lys Arg Glu Asp Leu Trp 
        835                 840                 845             


Cys Gly Ser Leu Ile Gly His Arg Pro Arg Thr Thr Trp Ala Glu Asn 
    850                 855                 860                 


Ile Lys Asn Thr Val Asn Met Val Arg Arg Ile Ile Gly Asp Glu Glu 
865                 870                 875                 880 


Lys Tyr Met Asp Tyr Leu Ser Thr Gln Val Arg Tyr Leu Gly Glu Glu 
                885                 890                 895     


Gly Ser Thr Pro Gly Val Leu 
            900             


<210>  2
<211>  2712
<212>  DNA
<213>  Zika Virus

<400>  2
gggggtggaa caggagagac cctgggagag aaatggaagg cccgcctgaa ccagatgtcg       60

gccctggagt tctactccta caaaaagtca ggcatcaccg aggtgtgcag agaagaagcc      120

cgccgcgccc tcaaggacgg tgtggcaacg ggaggccatg ctgtgtcccg aggaagtgca      180

aagctgagat ggttggtgga gcggggatac ctgcagcccc atggaaaggt cattgatctt      240

ggatgtggca gagggggctg gagctactac gccgccacca tccgcaaagt tcaagaagtg      300

aaaggataca caaaaggagg ccctggtcat gaagaaccca tgttggtgca aagctatggg      360

tggaacatag tccgtcttaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt      420

gacacgttgc tgtgtgatat aggtgagtca tcatctagtc ctgaagtgga agaagcacgg      480

acgctcagag tcctctccat ggtgggggat tggcttgaaa aaagaccagg agccttttgt      540

ataaaagtgt tgtgcccata caccagcact atgatggaaa ccctggagcg actgcagcgt      600

aggtatgggg gaggactggt cagagtgcca ctctcccgca actctacaca tgagatgtac      660

tgggtctctg gagcgaaaag caacaccata aaaagtgtgt ccaccacgag ccagctcctc      720

ttggggcgca tggacgggcc caggaggcca gtgaaatatg aggaggatgt gaatctcggc      780

tctggcacgc gggctgtggt aagctgcgct gaagctccca acatgaagat cattggtaac      840

cgcattgaga ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca      900

tataggacat gggcttacca tggaagctat gaggccccta cacaagggtc agcgtcctct      960

ctggtaaacg gggttgtcag gctcctgtca aaaccctggg atgtggtgac tggagtcaca     1020

ggaatagcta tgaccgacac cacaccgtat ggtcagcaaa gagttttcaa ggaaaaagtg     1080

gacactaggg tgccagaccc ccaagaaggc actcgtcagg ttatgagcat ggtctcttcc     1140

tggttgtgga aagagctagg caaacacaaa cggccacgag tctgtaccaa agaagagttc     1200

atcaacaagg ttcgtagcaa tgcagcatta ggggcaatat ttgaagagga aaaagagtgg     1260

aagactgcag tggaagctgt gaacgatcca aggttctggg ctctagtgga caaggaaaga     1320

gagtaccacc tgagaggaga gtgccagagc tgtgtgtaca acatgatggg aaaaagagaa     1380

aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta tatgtggcta     1440

ggggctagat ttctagagtt cgaagccctt ggattcttga acgaggatca ctggatgggg     1500

agagagaact caggaggtgg tgttgaaggg ctgggattac aaagactcgg atatgtccta     1560

gaagagatga gtcgcatacc aggaggaagg atgtatgcag atgacactgc tggctgggac     1620

acccgcatca gcaggtttga tctggagaat gaagctctaa tcaccaacca aatggagaaa     1680

gggcacaggg ccttggcatt ggccataatc aagtacacat accaaaacaa agtggtaaag     1740

gtccttagac cagctgaaaa agggaagaca gttatggaca ttatttcaag acaagaccaa     1800

agggggagcg gacaagttgt cacttacgct cttaatacat tcaccaacct agtggtgcag     1860

ctcattcgga atatggaggc tgaggaagtt ttggagatgc aagacttgtg gctgctgcgg     1920

aggccagaga aagtgaccaa ctggttgcag agcaacggat gggataggct caaacgaatg     1980

gcagtcagtg gagatgattg cgttgtgaag ccaattgatg ataggttcgc acatgccctc     2040

aggttcttga atgatatggg aaaagttagg aaggacacac aagagtggaa accctcaaca     2100

ggatgggaca actgggaaga agttccgttt tgctcccacc atttcaacaa gctccatctc     2160

aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgggcc     2220

cgcgtctctc caggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat     2280

gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccgactgat ggccaatgcc     2340

atttgttcat ctgtgccagt tgactgggtt ccaactggga gaactacctg gtcaatccat     2400

ggaaagggag aatggatgac cactgaagac atgcttgtgg tgtggaacag agtgtggatt     2460

gaggagaacg accacatgga agacaagacc ccagttacga aatggacaga cattccctat     2520

ttgggaaaaa gggaagactt gtggtgtgga tctctcatag ggcacagacc gcgcaccacc     2580

tgggctgaga acattaaaaa cacagtcaac atggtgcgca ggatcatagg tgatgaagaa     2640

aaatacatgg actacctatc cacccaagtg cgctacttgg gtgaagaagg gtctacacct     2700

ggagtgctat aa                                                         2712


<210>  3
<211>  2712
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  3
gggggtggga ctggagagac acttggagag aaatggaagg cccggctcaa ccagatgtcg       60

gccctcgagt tctactccta caaaaagtca ggcatcaccg aggtgtgcag agaagaagcc      120

cgccgcgcac ttaaggacgg ggtggcaacg ggaggccatg ctgtgtccag gggaagtgca      180

aagctgagat ggctcgtgga gaggggatac ctgcagcccc atggaaaggt cattgatctt      240

ggatgtggca gggggggctg gagctactac gccgccacca tccgcaaagt tcaagaagtg      300

aaaggataca caaaaggagg ccctggtcat gaagaaccca tgttggttca aagctatggg      360

tggaacatag tccggctcaa gagtggggtg gacgtctttc atatggcggc tgagccgtgt      420

gacacacttc tgtgtgatat aggtgagtca tcatctagtc ctgaagtgga agaagcacgg      480

actctcaggg tgctctccat ggttggggat tggctcgaaa aaagaccagg agccttttgt      540

ataaaagtgt tgtgcccata caccagcact atgatggaaa ccctcgagcg gctccagcgt      600

aggtatgggg gagggctggt cagggtgcca ctttcccgca actctacaca tgagatgtac      660

tgggtgtctg gagcgaaaag caacaccata aaaagtgtgt ccaccacgag ccagctcctc      720

ttggggcgca tggacgggcc caggaggcca gtgaaatatg aggaggatgt gaatctcggc      780

tctgggactc gggctgtggt tagctgcgct gaagctccca acatgaagat cattggtaac      840

cgcattgaga ggatccgcag tgagcacgcg gaaacgtggt tctttgacga gaaccaccca      900

tataggactt gggcttacca tggaagctat gaggccccta cacaagggtc agcgtccagc      960

ctggtaaacg gggtggtcag gctcctgtca aaaccctggg atgtggttac tggggtgaca     1020

ggaatagcta tgaccgacac cacaccgtat ggtcagcaaa gggtgttcaa ggaaaaagtg     1080

gacactaggg tgccagaccc ccaagaaggg actcgtcagg ttatgagcat ggtttcttcc     1140

tggctctgga aagagctagg caaacacaaa cggccacggg tgtgtaccaa agaagagttc     1200

atcaacaagg ttcgtagcaa tgcagcactt ggggcaatct ttgaagagga aaaagagtgg     1260

aagactgcag tggaagctgt gaacgatcca aggttctggg cacttgtgga caaggaaaga     1320

gagtaccacc tgaggggaga gtgccagagc tgtgtgtaca acatgatggg aaaaagagaa     1380

aagaaacaag gggaatttgg aaaggccaag ggcagccgcg ccatctggta tatgtggctc     1440

ggggctagat ttctcgagtt cgaagcactt ggattcttga acgaggatca ctggatgggg     1500

agagagaact caggaggtgg ggtggaaggg ctcgggctac aaaggctcgg atatgtcctc     1560

gaagagatga gtcgcatacc aggaggaagg atgtatgcag atgacactgc tggctgggac     1620

acccgcatca gcaggtttga tctcgagaat gaagcactta tcaccaacca aatggagaaa     1680

gggcacaggg cacttgcact tgccataatc aagtacacat accaaaacaa agtggttaag     1740

gtccttagac cagctgaaaa agggaagaca gttatggata ttatttcaag acaagaccaa     1800

agggggagcg gacaagtggt tacttacgca cttaatacat tcaccaacct ggttgtgcag     1860

ctcattcgga atatggaggc tgaggaagtt ctcgagatgc aagacttgtg gctcctgcgg     1920

aggccagaga aagtgaccaa ctggctccag agcaacggat gggataggct caaacgaatg     1980

gcagtcagtg gagatgattg cgtggttaag ccaattgatg ataggttcgc acatgcactt     2040

aggttcttga atgatatggg aaaagttagg aaggacacac aagagtggaa accctcaaca     2100

ggatgggaca actgggaaga agttccgttt tgctcccacc atttcaacaa gctccatctc     2160

aaggacggga ggtccattgt ggttccctgc cgccaccaag atgaactgat tggccgggcc     2220

cgggtgtctc caggggcggg atggagcatc cgggagactg cttgcctagc aaaatcatat     2280

gcgcaaatgt ggcagctcct ttatttccac agaagggacc tccggctcat ggccaatgcc     2340

atttgttcat ctgtgccagt tgactgggtg ccaactggga ggactacctg gtcaatccat     2400

ggaaagggag aatggatgac cactgaagat atgctggttg tgtggaacag ggtgtggatt     2460

gaggagaacg accacatgga agacaagacc ccagttacga aatggactga tattccctat     2520

ttgggaaaaa gggaagactt gtggtgtgga agcctcatag ggcacagacc gcggactacc     2580

tgggctgaga acattaaaaa cacagtcaac atggttcgca ggatcatagg tgatgaagaa     2640

aaatacatgg actacctatc cacccaagtg cgctacttgg gtgaagaagg gtctacacct     2700

ggggtgctat aa                                                         2712


