                         SEQUENCE LISTING

<110>  AprilBio Co., Ltd.
 
<120>  MONOCLONAL ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR 
       SUPPRESSING CD73 IMMUNE CHECKPOINT AND USES THEREOF

<130>  2662-0003WO01

<150>  KR 10-2020-0043607
<151>  2020-04-09

<150>  KR 10-2020-0144595
<151>  2020-11-02

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of L4-66

<400>  1

Asp Tyr Ala Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of L4-66

<400>  2

Gly Ile Ser Asp Gly Gly Ser Ala Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L4-66

<400>  3

Ala Gly Ser Ser Trp Tyr Phe Gly Ala Phe Asp Ile 
1               5                   10          


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of L6-1

<400>  4

Thr His Gly Met His 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of L6-1

<400>  5

Ala Ile Ser Tyr Asp Gly Ser Asn Gln Tyr Tyr Gly Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L6-1

<400>  6

Asp Val Asp Trp Gly Leu Pro Tyr Tyr Phe Gly Met Asp Val 
1               5                   10                  


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of L2-3

<400>  7

Asp Thr Tyr Met His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of L2-3

<400>  8

Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L2-3

<400>  9

Gln Pro Val Val Val Leu Ala Ala Asn Val Tyr Tyr Arg Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of L4-4, L4-5

<400>  10

Ser Trp Leu Gly Glu Phe Pro Tyr 
1               5               


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of L4-4, L4-5

<400>  11

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L4-4

<400>  12

Ser Trp Leu Gly Glu Phe Pro Tyr 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L4-5

<400>  13

Asp Pro Gly Ile Ala Ala Ala Gly Phe Asp Tyr 
1               5                   10      


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of L4-46

<400>  14

Ser Ser Ala Ile His 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of L4-46

<400>  15

Val Ile Ser Tyr Asp Gly Asn Gly Lys Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L4-46

<400>  16

Ile Arg Gly Tyr Gly Leu Val Asp Met Asp Val 
1               5                   10      


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of L8-24

<400>  17

Asn Tyr Gly Ile Thr 
1               5   


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of L8-24

<400>  18

Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of L8-2

<400>  19

Gly Trp Gly Phe Ala His 
1               5       


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of L4-4, L4-5, L4-46, L4-66

<400>  20

Arg Ala Ser Gln Asn Ile Gly Ser Trp Leu Ala 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of L4-4, L4-5, L4-46, L4-66

<400>  21

Arg Ala Ser Asn Leu Arg Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of L4-4, L4-5, L4-46, L4-46

<400>  22

Gln Gln Ala Thr Ile Phe Pro Leu Thr 
1               5                   


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of L6-1

<400>  23

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of L6-1

<400>  24

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  25

Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr 
1               5                   10  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of L2-3

<400>  26

Arg Ala Ser Gln Ser Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of L2-3

<400>  27

Gly Ala Ser Arg Leu Glu Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of L2-3

<400>  28

Gln Gln Ser Asp Ser Val Pro Val Thr 
1               5                   


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of L8-2

<400>  29

Gln Ala Ser Asp Lys Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of L8-24

<400>  30

Asp Ala Ser Asn Leu Gln Thr 
1               5           


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of L8-24

<400>  31

Gln Gln Tyr Asn Ser Tyr Pro Tyr Ala Thr 
1               5                   10  


<210>  32
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L4-66

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Tyr Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Asn Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asp Gly Gly Ser Ala Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Ser Ser Trp Tyr Phe Gly Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  33
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L6-1

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Asn Gln Tyr Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Asp Trp Gly Leu Pro Tyr Tyr Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L2-3

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Ala Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asn Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Pro Val Val Val Leu Ala Ala Asn Val Tyr Tyr Arg Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  35
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L4-4

<400>  35

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Trp Leu Gly Glu Phe Pro Tyr Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L4-5

<400>  36

Gln Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ile Ala Ala Ala Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L4-46

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Asn Gly Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Asn Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ile Arg Gly Tyr Gly Leu Val Asp Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of L8-24

<400>  38

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Gly Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of L4-66,  L4-4, L4-5, L4-46

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ala Thr Ile Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  40
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of L6-1

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of L2-3

<400>  41

Asp Ile Gln Thr Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Val Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  42
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of L8-24

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Gln Ala Ser Asp Lys Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  43
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of L4-66

<400>  43
caggtgcagc tggtgcagtc cggaggaggc ctggtgcagc caggaagata tttgcggctg       60

tcctgcgtgg cctccggctt caacttcgac gactacgcca tgcactgggt gaggcaggct      120

cccggaaagg ccctggagtg ggtgtccgga atcagcgatg gcggcagcgc caccacctac      180

gctgactctg tgaagggcag gtttaccatc tccagggata acgctaagaa taccctgtat      240

ctgcagctga atagcctgac cgctgaggac accgccgtgt attattgcgc cagggccggc      300

agcagctggt attttggcgc cttcgatatt tggggccagg gcaccctggt gaccgtgtct      360

agc                                                                    363


<210>  44
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of L4-66

<400>  44
gatattcaga tgacccagag ccccagcagc ctgagcgcta gcgtgggcga cagggtgacc       60

atcacctgta gggctagcca gaacatcggc agctggctgg cctggtacca gcagaagcct      120

ggcaacgctc ctaagctgct gatctacagg gctagcaatc tgcggagcgg cgtgcccagc      180

aggtttagcg gctccggctc cggcaccgac ttcaccctga ccatcagctc cctgcagccc      240

gaggattttg ccacctattt ttgccagcag gccaccatct ttcctctgac cttcggccag      300

ggcaccaagc tggagatcaa g                                                321


<210>  45
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of L6-1

<400>  45
caggtgcagc tggtgcagtc cggcggcgga gtggtgcagc ctggaagatc cctgaggctg       60

agctgcgccg ccagcggatt cactttcaat acccacggca tgcactgggt gaggcaggcc      120

cctggcaagg gcctggagtg ggtggctgct atctcctacg acggcagcaa tcagtactac      180

ggcgagagcg tgaagggccg gttcaccatc agccgggaca acagccggga caccctgtat      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt attactgcgc tagggatgtg      300

gactggggcc tgccctatta cttcggcatg gacgtgtggg gccagggcac cctggtgacc      360

gtgagctcc                                                              369


<210>  46
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of L6-1

<400>  46
gacatccaga tgacccagtc cccctcctcc ctgagcgcta gcgtgggcga tagggtgacc       60

atcacctgta gggcttccca gtccatctcc tcctacctga attggtatca gcagaagccc      120

ggcaaggccc ctaagctgct gatctacgct gcctccagcc tgcagagcgg cgtgccatcc      180

aggtttagcg gcagcggcag cggaaccgat ttcaccctga ccatcagctc cctgcagccc      240

gaggactttg ctacctatta ctgccagcag tcctactcca ccccccctta tacctttggc      300

cagggcacca agctggagat caag                                             324


<210>  47
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1

<400>  47
gatcaacaag cttgccacca tggagaccca cagccag                                37


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1

<400>  48
cccctccacc ccgctcagcc acag                                              24


<210>  49
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1

<400>  49
ctgagcgggg tggaggggga catccagatg acccagtctc catcttccct gtct             54


<210>  50
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1

<400>  50
ccaccgtacg tttgatttcc agcttggtcc cttggccgaa ggt                         43


<210>  51
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1

<400>  51
gatcaacgaa ttcgccacca tggagtggtc ctgggtc                                37


<210>  52
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1

<400>  52
ggaaagcact ccggtggtca cgctgag                                           27


<210>  53
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1

<400>  53
gcgtgaccac cggagtgctt tcccaggtgc agctggtgca gtctgg                      46


<210>  54
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1

<400>  54
cagtgggccc ttggtggagg ctgaggagac ggtgaccagg gtgccttg                    48


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1 (APBA2-01)

<400>  55
gctagacacg gtcaccaggg tg                                                22


<210>  56
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1 (APBA2-01)

<400>  56
caccctggtg accgtgtcta gcgcatcaac aaaaggtcct tcagttttcc cc               52


<210>  57
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1 (APBA2-01)

<400>  57
aggaagacgc ttttagaggc ggccgctcac tttcctggtg aaag                        44


<210>  58
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1 (APBA2-02)

<400>  58
ctaggagcgg ccacggtccg cttgatctcc agcttggtgc cctg                        44


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1 (APBA2-02)

<400>  59
cggaccgtgg ccgctcctag                                                   20


<210>  60
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of Human IgG1 (APBA2-02)

<400>  60
ccactctaga gaagacgctt ttagatcaac actc                                   34


<210>  61
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1 (APBA2-02)

<400>  61
ggagctcacg gtcaccaggg tgccctg                                           27


<210>  62
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Human IgG1 (APBA2-02)

<400>  62
gtgaccgtga gctccgcatc aacaaaaggt ccttcagttt tcccc                       45


<210>  63
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Mouse IgG1 (APBA2-01)

<400>  63
caccctggtg accgtgtcta gcgctaagac taccccacca tcagtctatc cc               52


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Mouse IgG1 (APBA2-01)

<400>  64
atcggcggcc gcgaagacgc ttttagatca                                        30


<210>  65
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Mouse IgG2a (APBA2-01)

<400>  65
caccctggtg accgtgtcta gcgctaaaac taccgcacct agcgtgtatc ct               52


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 59H VH3-9

<400>  66

Asp Tyr Ala Met His 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 59H VH3-9

<400>  67

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 59H VH3-9

<400>  68

Ala Arg Gly Tyr Ser Tyr Gly Glu Gly Ala Phe Asp Ile 
1               5                   10              


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 60H VH3-9

<400>  69

Asp Tyr Ala Met His 
1               5   


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 60H VH3-9

<400>  70

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 60H VH3-9

<400>  71

Asp Ile Trp Tyr Gly Gly Phe Phe Gly Ala Phe Asp Ile 
1               5                   10              


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 69H VH3-9

<400>  72

Asp Tyr Ala Met His 
1               5   


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 69H VH3-9

<400>  73

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 69H VH3-9

<400>  74

Gly Gly Phe Gly Val Val Thr Ala Leu Thr Val 
1               5                   10      


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 75H VH1-18

<400>  75

Ser Tyr Gly Ile Ser 
1               5   


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 75H VH1-18

<400>  76

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 75H VH1-18

<400>  77

Gly Thr Tyr Tyr Met Asp Val 
1               5           


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 290H VH3-30

<400>  78

Arg Tyr Gly Met His 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 290H VH3-30

<400>  79

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 290H VH3-30

<400>  80

Gly Asp Ser Ser Gly Phe Leu Asn Ala Phe Asp Ile 
1               5                   10          


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 59L VL1-44

<400>  81

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp Thr Val Thr 
1               5                   10              


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 59L VL1-44

<400>  82

Ser Asn Ser Gln Arg Pro Ser 
1               5           


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 59L VL1-44e

<400>  83

Ala Thr Trp Asp Ala Ser Leu Lys Ala Val Val 
1               5                   10      


<210>  84
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 60L VL1-47

<400>  84

Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Ser Val Tyr 
1               5                   10              


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 60L VL1-47

<400>  85

Arg Asn Phe Gln Arg Pro Ser 
1               5           


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 60L VL1-4

<400>  86

Ala Gly Trp Asp Asp Ser Val Arg Gly Tyr Val 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 69L VK1-16

<400>  87

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 69L VK1-16

<400>  88

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 69L VK1-1

<400>  89

Gln Gln Tyr Lys Ser Tyr Pro Leu Thr 
1               5                   


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 75L VK1-12

<400>  90

Arg Ala Asn Gln Asp Ile Thr Trp Leu Val 
1               5                   10  


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 75L VK1-12

<400>  91

Gly Ala Ser Ser Ser Gln Gly 
1               5           


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 75L VK1-12

<400>  92

Gln Gln Ala Asp Arg Tyr Pro Leu Thr 
1               5                   


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 290L VK1-33

<400>  93

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 59H VH3-9

<400>  94

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 290L VK1-33

<400>  95

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  96
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 59H VH3-9

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Arg Gly Tyr Ser Tyr Gly Glu Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  97
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 59L VL1-44

<400>  97

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asp 
            20                  25                  30          


Thr Val Thr Trp Tyr Gln Asn Leu Pro Gly Thr Ala Pro His Val Val 
        35                  40                  45              


Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ala Ser Leu 
                85                  90                  95      


Lys Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  98
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 60H VH3-9

<400>  98

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Trp Tyr Gly Gly Phe Phe Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  99
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 60L VL1-47

<400>  99

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Pro Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Tyr Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Phe Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ala Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Gly Trp Asp Asp Ser Val 
                85                  90                  95      


Arg Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  100
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 69H VH3-9

<400>  100

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Phe Gly Val Val Thr Ala Leu Thr Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  101
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 69L VK1-16

<400>  101

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105             


<210>  102
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 75H VH1-18

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  103
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 75L VK1-12

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Thr Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Asn Gln Asp Ile Thr Trp Leu 
            20                  25                  30          


Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Met Ser 
        35                  40                  45              


Gly Ala Ser Ser Ser Gln Gly Gly Ala Pro Ser Arg Phe Ser Val Ser 
    50                  55                  60                  


Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Arg Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  104
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 290H VH3-3

<400>  104

Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
        35                  40                  45              


Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Gly Asp Ser Ser Gly Phe Leu Asn Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  105
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 290L VK1-33

<400>  105

Val Ile Trp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105             


<210>  106
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of 59H VH3-9

<400>  106
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagcccgt      300

ggatacagct atggcgaggg ggcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcgagc                                                                 366


<210>  107
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of 59L VL1-44

<400>  107
agctatgagc tgactcagcc accctcagcc tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtgatactg tgacctggta ccagaacctc      120

ccaggaacgg ccccccatgt cgtcatatat agtaatagtc agcggccctc aggggtccct      180

gaccgcttct ctggctccaa gtctggcacc tcagcctccc tggccatcac tggtctccag      240

tctgaggatg aggctgatta ttactgtgca acatgggatg ccagtctgaa ggccgtggtc      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  108
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of 60H VH3-9

<400>  108
cagctgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagatatt      300

tggtatggtg gcttctttgg ggcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcgagc                                                                 366


<210>  109
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of 60L VL1-47

<400>  109
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcactatt       60

ccttgttctg gaagcagctc caacatcgga actaattctg tttattggta ccagcaattt      120

ccaggaacgg cccccaagct cctcatctat aggaattttc agcggccctc aggggtccct      180

gaccgatttt ctggctccaa gtctggcacc tccgcctccc tggccatcgc tggactccgg      240

tccgaggatg aggctgatta ttattgtgcg ggatgggatg acagtgtgag gggttatgtc      300

ttcggaactg ggaccaagct gaccgtccta ggt                                   333


<210>  110
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of 69H VH3-9

<400>  110
gaagtgcagc tggtggagac tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagggggc      300

tttggagtgg ttacggccct tacagtctgg ggccaaggga ccacggtcac cgtctcgagc      360


<210>  111
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of 69L VK1-16

<400>  111
gccatccagt tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataaaagtt acccgctcac attcggcgga      300

gggaccaaag tggatatcaa acgt                                             324


<210>  112
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of 75H VH1-18

<400>  112
caggtacagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctacggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaactat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagggacc      300

tactacatgg acgtctgggg caaagggacc acggtcaccg tctcgagc                   348


<210>  113
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of 75L VK1-12

<400>  113
gacatccaga tgacccagtc tccatcttcc gtgactgcat ctgtaggaga cagagtcagc       60

atcacttgtc gggcgaatca ggatattact tggttagtct ggtatcagca gaaaccaggg      120

aaagccccta agttcctgat gtctggtgca tccagttcgc aaggtggggc cccatcaagg      180

ttcagcgtca gtgaatctgg gacagacttc actctcacca tcagcagcct gcagccggaa      240

gattttgcaa cttactattg tcaacaggct gacagatatc cgctcacttt cggcggaggg      300

accaaggtgg agatcaaacg t                                                321


<210>  114
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH of 290H VH3-30

<400>  114
caggtacagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agatatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagaggggat      300

agtagtgggt tcttgaatgc ttttgatatc tggggccaag ggacaatggt caccgtctcg      360

agc                                                                    363


<210>  115
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL of 290L VK1-33

<400>  115
gtcatctgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccccctcac tttcggcgga      300

gggaccaaag tggatatcaa acgt                                             324


