                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado, a body corporate
       Pfizer Inc.
       Spencer, Sabrina
       Arora, Mansi
       Dann, Stephen G
       Goodman Miller, Nichol L
       VanArsdale, Todd L
 
<120>  CO-TREATMENT WITH CDK4/6 AND CDK2 INHIBITORS TO SUPPRESS TUMOR 
       ADAPTATION TO CDK2 INHIBITORS

<130>  PC072580-02

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (11)..(11)
<223>  Phosphorylation on Threonine

<400>  1

Asp Val Pro Pro Leu Ser Glu Thr Glu Ala Thr Pro Val Pro Ile Lys 
1               5                   10                  15      


<210>  2
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (21)..(21)
<223>  Phosphorylation on Threonine

<400>  2

Gly Ile Ala Ser Thr Ser Asp Pro Pro Thr Ala Asn Ile Lys Pro Thr 
1               5                   10                  15      


Pro Val Val Ser Thr Pro Ser Lys 
            20                  


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapians


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (10)..(10)
<223>  Phosphorylation on Threonine

<400>  3

Ser Val Ser Ser Val Leu Ser Ser Leu Thr Pro Ala Lys 
1               5                   10              


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (14)..(14)
<223>  Phosphorylation on Serine

<400>  4

Glu Leu Pro Ser Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser 
1               5                   10                  15      


Lys 
    


<210>  5
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (13)..(13)
<223>  Phosphorylation on Serine

<400>  5

Ala Gly Val Val Asn Gly Thr Gly Ala Pro Gly Gln Ser Pro Gly Ala 
1               5                   10                  15      


Gly Arg 
        


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (10)..(10)
<223>  Phosphorylation on Serine

<400>  6

Val Asn Phe Pro Glu Asn Gly Phe Leu Ser Pro Asp Lys 
1               5                   10              


<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (11)..(11)
<223>  Phosphorylation on Serine

<400>  7

Arg Val Ile Ala Ile Asp Ser Asp Ala Glu Ser Pro Ala Lys 
1               5                   10                  


<210>  8
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (14)..(14)
<223>  Phosphorylation on Threonine

<400>  8

Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn Ser Val Thr Pro Arg 
1               5                   10                  15      


<210>  9
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (12)..(12)
<223>  Phosphorylation on Serine

<400>  9

Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro Lys 
1               5                   10                  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (14)..(14)
<223>  Phosphorylation on Serine

<400>  10

Gly Gly Val Thr Gly Ser Pro Glu Ala Ser Ile Ser Gly Ser Lys 
1               5                   10                  15  


<210>  11
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (3)..(3)
<223>  Phosphorylation on Threonine

<400>  11

Thr Asn Thr Pro Gln Gly Val Leu Pro Ser Ser Gln Leu Lys 
1               5                   10                  


<210>  12
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (28)..(28)
<223>  Phosphorylation on Serine

<400>  12

Thr Ala Pro Ala Ala Pro Ala Glu Asp Ala Val Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Pro Ser Glu Pro Ser Glu Pro Ser Arg Pro Ser Pro Gln Pro Lys 
            20                  25                  30          


<210>  13
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (9)..(9)
<223>  Phosphorylation on Threonine

<400>  13

Glu Val Val Lys Pro Val Pro Ile Thr Ser Pro Ala Val Ser Lys 
1               5                   10                  15  


<210>  14
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (15)..(15)
<223>  Phosphorylation on Serine

<400>  14

Gln Glu Gln Ile Asn Thr Glu Pro Leu Glu Asp Thr Val Leu Ser Pro 
1               5                   10                  15      


Thr Lys Lys 
            


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (8)..(8)
<223>  Phosphorylation on Serine

<400>  15

His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro Gln Val Leu Ala Gln 
1               5                   10                  15      


Lys 
    


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (13)..(13)
<223>  Phosphorylation on Serine

<400>  16

Glu Lys Glu Pro Gly Glu Gln Ala Ser Val Pro Leu Ser Pro Lys 
1               5                   10                  15  


<210>  17
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (11)..(11)
<223>  Phosphorylation on Serine

<400>  17

Ala Gly Gly Gly Gly Gly Leu Gly Ala Gly Ser Pro Ala Leu Ser Gly 
1               5                   10                  15      


Gly Gln Gly Arg 
            20  


<210>  18
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (9)..(9)
<223>  Phosphorylation on Serine

<400>  18

Asn Cys Pro Ala Val Thr Leu Thr Ser Pro Ala Lys 
1               5                   10          


<210>  19
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (2)..(2)
<223>  Phosphorylation on Serine

<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (8)..(8)
<223>  Phosphorylation on Serine

<400>  19

His Ser Pro Ile Ala Pro Ser Ser Pro Ser Pro Gln Val Leu Ala Gln 
1               5                   10                  15      


Lys 
    


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (11)..(11)
<223>  Phosphorylation on Threonine

<400>  20

Asp Gly Val Leu Thr Leu Ala Asn Asn Val Thr Pro Ala Lys 
1               5                   10                  


<210>  21
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (11)..(11)
<223>  Phosphorylation on Threonine

<400>  21

Asp Ser Val Val Ser Leu Glu Ser Gln Lys Thr Pro Ala Asp Pro Lys 
1               5                   10                  15      


<210>  22
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (17)..(17)
<223>  Phosphorylation on Serine

<400>  22

Pro Gln Val Ala Ala Gln Ser Gln Pro Gln Ser Asn Val Gln Gly Gln 
1               5                   10                  15      


Ser Pro Val Arg 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (17)..(17)
<223>  Phosphorylation on Threonine

<400>  23

Ser Gln Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn 
1               5                   10                  15      


Thr Pro Gln Lys 
            20  


<210>  24
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (8)..(8)
<223>  Phosphorylation on Serine

<220>
<221>  M(15.995)
<222>  (17)..(17)
<223>  Oxidation on Methionine

<400>  24

Tyr Ser Gln Ser Ala Pro Gly Ser Pro Val Ser Ala Gln Pro Val Ile 
1               5                   10                  15      


Met Ala Val Pro Pro Arg Pro Ser Ser Leu Val Ala Lys 
            20                  25                  


<210>  25
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (2)..(2)
<223>  Phosphorylation on Serine

<400>  25

Gly Ser Pro Ile Pro Tyr Gly Leu Gly His His Pro Pro Val Thr Ile 
1               5                   10                  15      


Gly Gln Pro Gln Asn Gln His Gln Glu Lys 
            20                  25      


<210>  26
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (14)..(14)
<223>  Phosphorylation on Serine

<400>  26

Arg Ile Val Ala His Ala Val Glu Val Pro Ala Val Gln Ser Pro Arg 
1               5                   10                  15      


<210>  27
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (1)..(1)
<223>  Phosphorylation on Serine

<400>  27

Ser Pro Ser Pro Ala Pro Ala Pro Ala Pro Ala Ala Ala Ala Gly Pro 
1               5                   10                  15      


Pro Thr Arg 
            


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (2)..(2)
<223>  Phosphorylation on Serine

<400>  28

Ala Ser Pro Gln Glu Asn Gly Pro Ala Val His Lys 
1               5                   10          


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (8)..(8)
<223>  Phosphorylation on Serine

<400>  29

Val Asn Asp Ala Glu Pro Gly Ser Pro Glu Ala Pro Gln Gly Lys 
1               5                   10                  15  


<210>  30
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (14)..(14)
<223>  Phosphorylation on Threonine

<400>  30

Asn Thr Gly Val Ser Pro Ala Ser Arg Pro Ser Pro Gly Thr Pro Thr 
1               5                   10                  15      


Ser Pro Ser Asn Leu Thr Ser Gly Leu Lys 
            20                  25      


<210>  31
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (12)..(12)
<223>  Phosphorylation on Serine

<400>  31

Pro Gln Ser Pro Val Ile Gln Ala Ala Ala Val Ser Pro Lys 
1               5                   10                  


<210>  32
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (13)..(13)
<223>  Phosphorylation on Serine

<400>  32

Ala Gly Gly Leu Asp Trp Pro Glu Ala Thr Glu Val Ser Pro Ser Arg 
1               5                   10                  15      


<210>  33
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (1)..(1)
<223>  Phosphorylation on Serine

<400>  33

Ser Pro Ser Pro Ala Pro Ala Pro Ala Pro Ala Ala Ala Ala Gly Pro 
1               5                   10                  15      


Pro Thr Arg Lys 
            20  


<210>  34
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (10)..(10)
<223>  Phosphorylation on Serine

<400>  34

Asp Val Pro Pro Asp Ile Leu Leu Asp Ser Pro Glu Arg Lys 
1               5                   10                  


<210>  35
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Oxidation on Methionine

<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (14)..(14)
<223>  Phosphorylation on Serine

<400>  35

Arg Tyr Ser Tyr Leu Thr Glu Pro Gly Met Ser Pro Gln Ser Pro Cys 
1               5                   10                  15      


Glu Arg 
        


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (10)..(10)
<223>  Phosphorylation on Serine

<400>  36

Ser Thr Val Gly Ser Ser Asp Asn Ser Ser Pro Gln Pro Leu Lys 
1               5                   10                  15  


<210>  37
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (5)..(5)
<223>  Phosphorylation on Serine

<400>  37

Asp Leu Leu Pro Ser Pro Ala Gly Pro Val Pro Ser Lys 
1               5                   10              


<210>  38
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (6)..(6)
<223>  Phosphorylation on Threonine

<400>  38

Asp Ser Glu Leu Lys Thr Pro Pro Ser Val Gly Pro Pro Ser Val Thr 
1               5                   10                  15      


Val Val Thr Leu Glu Ser Ala 
            20              


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Oxidation on Methionine

<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (5)..(5)
<223>  Phosphorylation on Serine

<400>  39

Thr Ala Met Pro Ser Pro Gly Val Ser Gln Asn Lys 
1               5                   10          


<210>  40
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (3)..(3)
<223>  Phosphorylation on Serine

<220>
<221>  MOD_RES_PHOSPHORYLATION
<222>  (7)..(7)
<223>  Phosphorylation on Serine

<400>  40

Ala Gly Ser Pro Arg Gly Ser Pro Leu Ala Glu Gly Pro Gln Ala Phe 
1               5                   10                  15      


Phe Pro Glu Arg 
            20  


