                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  MOLECULE

<130>  P121993PCT

<140>  PCT/GB2021/050865
<141>  2021-04-08

<150>  GB 2005331.0
<151>  2020-04-09

<150>  GB 2017358.9
<151>  2020-11-02

<150>  GB 2101491.5
<151>  2021-02-03

<160>  213   

<170>  PatentIn version 3.5

<210>  1
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  2
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn 
145             


<210>  3
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp 
1               5                   10                  15      


Val 
    


<210>  4
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn 
1               5                   10                  15      


Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile 
            20                  25                  30          


Asn Leu Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Met Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val 
    50                  55                  60                  


Asn Glu Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr 
65                  70                  75                  80  


Ala Glu Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly 
                85                  90                  95      


Lys Lys Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn 
            100                 105                 110         


Leu Cys Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile 
        115                 120                 125             


Thr Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
    130                 135                 140                 


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain from anti-Fas antibody

<400>  5

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ile Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Thr Thr Asn Tyr Ser Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Ile Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Leu Trp Ile Gly Glu Gly Asp Tyr Gly Leu Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain from anti-Fas antibody

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  7
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  8
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Leu Val Gly Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln 
1               5                   10                  15      


Lys Glu Leu Ala Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala 
            20                  25                  30          


Ser Ser Leu Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys 
        35                  40                  45              


Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg 
    50                  55                  60                  


Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser 
65                  70                  75                  80  


Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu 
                85                  90                  95      


Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn 
            100                 105                 110         


Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln 
        115                 120                 125             


Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly 
    130                 135                 140                 


Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr 
145                 150                 155                 160 


Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn 
                165                 170                 175     


Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
            180                 185                 


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal, C-terminal signal

<400>  9

Lys Asp Glu Leu 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal, C-terminal signal


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Lys Lys Xaa Xaa 
1               


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal, C-terminal signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Lys Xaa Lys Xaa Xaa 
1               5   


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal, RXR(R) motif of potassium channels


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Arg Xaa Arg Arg 
1               


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention sequence

<400>  13

Ser Glu Lys Asp Glu Leu 
1               5       


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention sequence, tail of adenoviral E19 protein

<400>  14

Lys Tyr Lys Ser Arg Arg Ser Phe Ile Asp Glu Lys Lys Met Pro 
1               5                   10                  15  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention sequence, HLA invariant chain

<400>  15

Met His Arg Arg Arg Ser Arg Ser Cys Arg 
1               5                   10  


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention sequence, HLA invariant chain


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Asp or Glu

<400>  16

Lys Xaa Xaa 
1           


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Golgi retention sequence, HLA invariant chain

<400>  17

Tyr Gln Arg Leu 
1               


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KDEL sequence in Fas-retaining molecule

<400>  18

Asp Pro Ala Glu Pro Ser Glu Lys Asp Glu Leu 
1               5                   10      


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  retention signal, tail of adenoviral E19 protein sequence

<400>  19

Asp Glu Lys Lys Met Pro 
1               5       


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal, TYRP-1 intracellular domain

<400>  20

Asn Gln Pro Leu Leu Thr Asp 
1               5           


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  21

Gly Gly Gly Gly Ser 
1               5   


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  23

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-Fas KDEL molecule with an Ig Kappa leader sequence

<400>  24

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  25
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-Fas-KDEL sequence

<400>  25

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys 
    50                  55                  60                  


Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Ile Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr Tyr 
                165                 170                 175     


Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Thr Thr Asn Tyr Ser Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Ile Ser Leu Asn 
    210                 215                 220                 


Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Trp Ile Gly Glu Gly Asp Tyr Gly Leu Asp Val Trp Gly 
                245                 250                 255     


Gln Gly Thr Thr Val Thr Val Ser Ser Asp Pro Ala Glu Pro Ser Glu 
            260                 265                 270         


Lys Asp Glu Leu 
        275     


<210>  26
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated Fas endodomain

<400>  26

Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn 
1               5                   10                  15      


Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ala 
            20                  25                  30          


Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser Asp Ser Glu 
        35                  40                  45              


Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
    50                  55                  60  


<210>  27
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated Fas, or FasdeltaDD

<400>  27

Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro 
145                 150                 155                 160 


Leu Ile Val Trp Val Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys 
                165                 170                 175     


His Arg Lys Glu Asn Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro 
            180                 185                 190         


Glu Thr Val Ala Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile 
        195                 200                 205             


Thr Ser Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu 
    210                 215                 220                 


Val 
225 


<210>  28
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fas with D260V point mutation

<400>  28

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Trp Ala Gln Val Thr Asp Ile Asn Ser Lys 
            20                  25                  30          


Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn Leu 
        35                  40                  45              


Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro Pro 
    50                  55                  60                  


Gly Glu Arg Lys Ala Arg Asp Cys Thr Trp Gly Asp Glu Pro Asp Cys 
65                  70                  75                  80  


Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His Phe Ser 
                85                  90                  95      


Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly Leu Glu 
            100                 105                 110         


Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg Cys Lys 
        115                 120                 125             


Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp Pro Cys 
    130                 135                 140                 


Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr Ser Asn 
145                 150                 155                 160 


Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp Leu Cys 
                165                 170                 175     


Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg Lys Glu 
            180                 185                 190         


Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser His 
        195                 200                 205             


Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Ser Asp 
    210                 215                 220                 


Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met Thr Leu 
225                 230                 235                 240 


Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Trp Glu Ala Lys Ile 
                245                 250                 255     


Val Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu Gln Lys Val 
            260                 265                 270         


Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys Glu Ala Tyr 
        275                 280                 285             


Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys Thr Leu Ala 
    290                 295                 300                 


Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser Asp Ser Glu 
305                 310                 315                 320 


Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330         


<210>  29
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DcR2 endodomain

<400>  29

Arg Lys Lys Phe Ile Ser Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly 
1               5                   10                  15      


Gly Gly Pro Glu Arg Val His Arg Val Leu Phe Arg Arg Arg Ser Cys 
            20                  25                  30          


Pro Ser Arg Val Pro Gly Ala Glu Asp Asn Ala Arg Asn Glu Thr Leu 
        35                  40                  45              


Ser Asn Arg Tyr Leu Gln Pro Thr Gln Val Ser Glu Gln Glu Ile Gln 
    50                  55                  60                  


Gly Gln Glu Leu Ala Glu Leu Thr Gly Val Thr Val Glu Ser Pro Glu 
65                  70                  75                  80  


Glu Pro Gln Arg Leu Leu Glu Gln Ala Glu Ala Glu Gly Cys Gln Arg 
                85                  90                  95      


Arg Arg Leu Leu Val Pro Val Asn Asp Ala Asp Ser Ala Asp Ile Ser 
            100                 105                 110         


Thr Leu Leu Asp Ala Ser Ala Thr Leu Glu Glu Gly His Ala Lys Glu 
        115                 120                 125             


Thr Ile Gln Asp Gln Leu Val Gly Ser Glu Lys Leu Phe Tyr Glu Glu 
    130                 135                 140                 


Asp Glu Ala Gly Ser Ala Thr Ser Cys Leu 
145                 150                 


<210>  30
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GITR endodomain

<400>  30

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  31
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD30 endodomain

<400>  31

His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys 
1               5                   10                  15      


Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg 
            20                  25                  30          


Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu 
        35                  40                  45              


Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr 
    50                  55                  60                  


Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp 
65                  70                  75                  80  


Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro 
                85                  90                  95      


Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile 
            100                 105                 110         


Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro 
        115                 120                 125             


Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu 
    130                 135                 140                 


Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro 
145                 150                 155                 160 


Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly 
                165                 170                 175     


Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185             


<210>  32
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XEDAR endodomain

<400>  32

Leu Tyr Cys Lys Gln Phe Phe Asn Arg His Cys Gln Arg Gly Gly Leu 
1               5                   10                  15      


Leu Gln Phe Glu Ala Asp Lys Thr Ala Lys Glu Glu Ser Leu Phe Pro 
            20                  25                  30          


Val Pro Pro Ser Lys Glu Thr Ser Ala Glu Ser Gln Val Ser Glu Asn 
        35                  40                  45              


Ile Phe Gln Thr Gln Pro Leu Asn Pro Ile Leu Glu Asp Asp Cys Ser 
    50                  55                  60                  


Ser Thr Ser Gly Phe Pro Thr Gln Glu Ser Phe Thr Met Ala Ser Cys 
65                  70                  75                  80  


Thr Ser Glu Ser His Ser His Trp Val His Ser Pro Ile Glu Cys Thr 
                85                  90                  95      


Glu Leu Asp Leu Gln Lys Phe Ser Ser Ser Ala Ser Tyr Thr Gly Ala 
            100                 105                 110         


Glu Thr Leu Gly Gly Asn Thr Val Glu Ser Thr Gly Asp Arg Leu Glu 
        115                 120                 125             


Leu Asn Val Pro Phe Glu Val Pro Ser Pro 
    130                 135             


<210>  33
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40 endodomain

<400>  33

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  34
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 endodomain

<400>  34

Arg Lys Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val 
1               5                   10                  15      


Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly 
            20                  25                  30          


Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys 
        35                  40                  45              


Ser Pro 
    50  


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA endodomain

<400>  35

Arg Lys Ile Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
1               5                   10                  15      


Ser Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr 
            20                  25                  30          


Gly Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu 
        35                  40                  45              


Cys Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp 
    50                  55                  60                  


His Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val 
65                  70                  75                  80  


Thr Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser 
                85                  90                  95      


Ala Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
            100                 105         


<210>  36
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fn14 endodomain

<400>  36

Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr Pro Ile Glu Glu Thr 
1               5                   10                  15      


Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile Gln 
            20                  25              


<210>  37
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB endodomain

<400>  37

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence tested, predicted as siRNA for Fas mRNA

<400>  38
ggacattact agtgactca                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence tested, predicted as siRNA for Fas mRNA

<400>  39
gttcaactgc ttcgtaatt                                                    19


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense siRNA sequence (knocks down Fas expression)

<400>  40
gugcaagugc aaaccagact t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense siRNA sequence (knocks down Fas expression)

<400>  41
gucugguuug cacuugcact t                                                 21


<210>  42
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-Fas shRNA sequence

<400>  42
ccgggtgcag atgtaaacca aacttctcga gaagtttggt ttacatctgc actttttg         58


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fas-gRNA encoding sequence

<400>  43
gagggtccag atgcccagca                                                   20


<210>  44
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fas-targeting gRNA sequence

<400>  44
ggaguugaug ucagucacuu                                                   20


<210>  45
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fas-targeting gRNA sequence

<400>  45
gugacugaca ucaacuccaa                                                   20


<210>  46
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fas-targeting gRNA sequence

<400>  46
cuuccucaau uccaaucccu                                                   20


<210>  47
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fas-targeting gRNA sequence

<400>  47
ugacaucaac uccaagggau                                                   20


<210>  48
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD3zeta endodomain

<400>  48

Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
1               5                   10                  15      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            20                  25                  30          


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
        35                  40                  45              


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    50                  55                  60                  


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
65                  70                  75                  80  


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                85                  90                  95      


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 


<210>  49
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 endodomain

<400>  49

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  50
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS endodomain

<400>  50

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  51
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4 endodomain

<400>  51

Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr 
1               5                   10                  15      


Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu Lys Gln 
            20                  25                  30          


Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
        35                  40      


<210>  52
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX-40 endodomain

<400>  52

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI endodomain

<400>  53

Lys Lys Arg Gly Asp Pro Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg 
1               5                   10                  15      


Gln Ser Pro Ala Lys Ser Ser Gln Asp His Ala Met Glu Ala Gly Ser 
            20                  25                  30          


Pro Val Ser Thr Ser Pro Glu Pro Val Glu Thr Cys Ser Phe Cys Phe 
        35                  40                  45              


Pro Glu Cys Arg Ala Pro Thr Gln Glu Ser Ala Val Thr Pro Gly Thr 
    50                  55                  60                  


Pro Asp Pro Thr Cys Ala Gly Arg Trp Gly Cys His Thr Arg Thr Thr 
65                  70                  75                  80  


Val Leu Gln Pro Cys Pro His Ile Pro Asp Ser Gly Leu Gly Ile Val 
                85                  90                  95      


Cys Val Pro Ala Gln Glu Gly Gly Pro Gly Ala 
            100                 105         


<210>  54
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 endodomain

<400>  54

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser 
        115 


<210>  55
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FasL having a deletion of residues 126-135

<400>  55

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Pro Pro Pro 
        115                 120                 125             


Glu Lys Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn 
    130                 135                 140                 


Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu 
145                 150                 155                 160 


Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr 
                165                 170                 175     


Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys 
            180                 185                 190         


Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr 
        195                 200                 205             


Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr 
    210                 215                 220                 


Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn 
225                 230                 235                 240 


Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu 
                245                 250                 255     


Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
            260                 265                 270     


<210>  56
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FasL having a deletion of residues 126-145

<400>  56

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Val Ala His 
        115                 120                 125             


Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu Glu Trp Glu Asp 
    130                 135                 140                 


Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly 
145                 150                 155                 160 


Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr 
                165                 170                 175     


Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr 
            180                 185                 190         


Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys 
        195                 200                 205             


Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr 
    210                 215                 220                 


Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn 
225                 230                 235                 240 


Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser Gln Thr Phe Phe 
                245                 250                 255     


Gly Leu Tyr Lys Leu 
            260     


<210>  57
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Ala Glu Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu 
1               5                   10                  15      


Arg Leu Val Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro 
            20                  25                  30          


Cys Arg Arg Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His 
        35                  40                  45              


Tyr Thr Gln Phe Trp Asn Tyr Leu Glu Arg Cys Arg Tyr Cys Asn Val 
    50                  55                  60                  


Leu Cys Gly Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His 
65                  70                  75                  80  


Asn Arg Ala Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe 
                85                  90                  95      


Cys Leu Glu His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro 
            100                 105                 110         


Gly Thr Pro Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr 
        115                 120                 125             


Phe Ser Ala Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn 
    130                 135                 140                 


Cys Thr Ala Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His 
145                 150                 155                 160 


Asp Thr Leu Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val 
                165                 170                 175     


Pro Gly Ala Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe 
            180                 185                 190         


Gln Asp Ile Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu 
        195                 200                 205             


Ala Pro Glu Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu 
    210                 215                 220                 


Gln Leu Lys Leu Arg Arg Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp 
225                 230                 235                 240 


Gly Ala Leu Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met 
                245                 250                 255     


Pro Gly Leu Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His 
            260                 265                 270     


<210>  58
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DcR3 sequence

<400>  58

Val Ala Glu Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu 
1               5                   10                  15      


Arg Leu Val Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro 
            20                  25                  30          


Cys Arg Arg Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His 
        35                  40                  45              


Tyr Thr Gln Phe Trp Asn Leu Glu Arg Cys Arg Tyr Cys Asn Val Leu 
    50                  55                  60                  


Cys Gly Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His Asn 
65                  70                  75                  80  


Arg Ala Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe Cys 
                85                  90                  95      


Leu Glu His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro Gly 
            100                 105                 110         


Thr Pro Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr Phe 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn Cys 
    130                 135                 140                 


Thr Ala Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His Asp 
145                 150                 155                 160 


Thr Leu Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val Pro 
                165                 170                 175     


Gly Ala Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe Gln 
            180                 185                 190         


Asp Ile Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu Ala 
        195                 200                 205             


Pro Glu Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu Gln 
    210                 215                 220                 


Leu Ala Leu Ala Ala Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp Gly 
225                 230                 235                 240 


Ala Leu Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met Pro 
                245                 250                 255     


Gly Leu Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His 
            260                 265                 270 


<210>  59
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, 
       CD8stk

<400>  59

Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45      


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, 
       Hinge

<400>  60

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  61
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, COMP

<400>  61

Ala Gly Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr 
1               5                   10                  15      


Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg 
            20                  25                  30          


Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45              


Ser Gly Lys 
    50      


<210>  62
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, 
       CH1-Hinge

<400>  62

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
1               5                   10                  15      


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            20                  25                  30          


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        35                  40                  45              


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    50                  55                  60                  


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
65                  70                  75                  80  


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
                85                  90                  95      


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            100                 105                 110 


<210>  63
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, 
       CH1-Hinge-CH2-CH3

<400>  63

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
1               5                   10                  15      


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            20                  25                  30          


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        35                  40                  45              


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    50                  55                  60                  


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
65                  70                  75                  80  


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
                85                  90                  95      


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        195                 200                 205             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, HuIG
       Kappa

<400>  64

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  65
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence suitable for tethering DcR3 to the plasma membrane, CD28
       Stalk

<400>  65

Ala Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polar anchor

<400>  66

Arg Lys Lys Arg 
1               


<210>  67
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rigid linker with truncations

<400>  67

Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45              


Leu Glu 
    50  


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA targeting TCR alpha chain constant region (TRAC-gRNA)

<400>  68
agagtctctc agctggtaca                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA targeting TCR beta chain constant region (TRBC-gRNA)

<400>  69
gcagtatctg gagtcattga                                                   20


<210>  70
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  71
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  calcineurin A alpha isoform

<400>  71

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  72
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  calcineurin B, type 1

<400>  72

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  73

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  74

Asn Pro Phe Xaa 
1               


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine-based sorting signal


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

Asn Pro Xaa Tyr 
1               


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine-based sorting signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<400>  76

Tyr Xaa Xaa Xaa 
1               


<210>  77
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  77

Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
1               5                   10          


<210>  78
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  78

Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr Glu 
1               5                   10          


<210>  79
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  79

Thr Asn Phe Thr Asn Pro Val Tyr Ala Thr Leu Tyr 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  80

Gly Asn Phe Ala Asn Pro Val Tyr Glu Ser Met Tyr 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Caenorhabditis elegans

<400>  81

Thr Thr Phe Thr Asn Pro Val Tyr Glu Leu Glu Asp 
1               5                   10          


<210>  82
<211>  12
<212>  PRT
<213>  Caenorhabditis elegans

<400>  82

Leu Arg Val Asp Asn Pro Leu Tyr Asp Pro Asp Ser 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  83

Ile Ile Phe Glu Asn Pro Met Tyr Ser Ala Arg Asp 
1               5                   10          


<210>  84
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  84

Thr Asn Phe Glu Asn Pro Ile Tyr Ala Gln Met Glu 
1               5                   10          


<210>  85
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  85

Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val 
1               5                   10          


<210>  86
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  86

Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
1               5                   10      


<210>  87
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  87

Trp Asp Thr Glu Asn Pro Ile Tyr Lys Gln Ala Thr 
1               5                   10          


<210>  88
<211>  11
<212>  PRT
<213>  Drosophila sp.

<400>  88

Ser Thr Phe Lys Asn Pro Met Tyr Ala Gly Lys 
1               5                   10      


<210>  89
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  89

His Gly Tyr Glu Asn Pro Thr Tyr Arg Phe Leu Glu 
1               5                   10          


<210>  90
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  90

Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu 
1               5                   10          


<210>  91
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  91

Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Tyr Phe Glu 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  92

Tyr Ala Ser Ser Asn Pro Glu Tyr Leu Ser Ala Ser 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  93

Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro 
1               5                   10          


<210>  94
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  94

Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val 
1               5                   10          


<210>  95
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  95

Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe 
1               5                   10          


<210>  96
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  96

Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
1               5                   10      


<210>  97
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  97

Lys His His His Ala Gly Tyr Glu Gln Phe 
1               5                   10  


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken LAMP-2a sequence

<400>  98

Lys Lys His His Asn Thr Gly Tyr Glu Gln Phe 
1               5                   10      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken LAMP-2b sequence

<400>  99

Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
1               5                   10      


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken LAMP-2c sequence

<400>  100

Arg Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
1               5                   10      


<210>  101
<211>  12
<212>  PRT
<213>  Drosophila sp.

<400>  101

Arg Arg Arg Ser Thr Ser Arg Gly Tyr Met Ser Phe 
1               5                   10          


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  earthworm LAMP sequence

<400>  102

Arg Lys Arg Ser Arg Arg Gly Tyr Glu Ser Val 
1               5                   10      


<210>  103
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  103

Lys Ser Ile Arg Ser Gly Tyr Glu Val Met 
1               5                   10  


<210>  104
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  104

His Cys Gly Gly Pro Arg Pro Gly Tyr Glu Thr Leu 
1               5                   10          


<210>  105
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  105

His Cys Arg Thr Arg Arg Ala Glu Tyr Glu Thr Leu 
1               5                   10          


<210>  106
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  106

Arg Arg Arg Pro Ser Ala Tyr Gln Ala Leu 
1               5                   10  


<210>  107
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  107

Arg Arg Arg Ser Tyr Gln Asn Ile Pro 
1               5                   


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  108

Lys Lys His Cys Ser Tyr Gln Asp Ile Leu 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  109

Arg Arg Arg Ser Ala Tyr Gln Asp Ile Arg 
1               5                   10  


<210>  110
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  110

Arg Lys Arg Arg Arg Ser Tyr Gln Asp Ile Met 
1               5                   10      


<210>  111
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  111

Lys Phe Cys Lys Ser Lys Glu Arg Asn Tyr His Thr Leu 
1               5                   10              


<210>  112
<211>  14
<212>  PRT
<213>  Drosophila sp.

<400>  112

Lys Phe Tyr Lys Ala Arg Asn Glu Arg Asn Tyr His Thr Leu 
1               5                   10                  


<210>  113
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  113

Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
1               5                   10                  


<210>  114
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  114

Lys Ile Arg Gln Arg His Gln Ser Ser Ala Tyr Gln Arg Ile 
1               5                   10                  


<210>  115
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  115

His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
1               5                   10                  15  


<210>  116
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  116

Ser Leu Ser Arg Gly Ser Gly Tyr Lys Glu Ile 
1               5                   10      


<210>  117
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  117

Arg Arg Leu Arg Lys Gly Tyr Thr Pro Leu Met Glu Thr 
1               5                   10              


<210>  118
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  118

Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser 
1               5                   10                  


<210>  119
<211>  18
<212>  PRT
<213>  Dictyostelium sp.

<400>  119

Lys Lys Leu Arg Gln Gln Lys Gln Gln Gly Tyr Gln Ala Ile Ile Asn 
1               5                   10                  15      


Asn Glu 
        


<210>  120
<211>  15
<212>  PRT
<213>  Dictyostelium sp.

<400>  120

Arg Ser Lys Ser Asn Gln Asn Gln Ser Tyr Asn Leu Ile Gln Leu 
1               5                   10                  15  


<210>  121
<211>  17
<212>  PRT
<213>  Dictyostelium sp.

<400>  121

Arg Lys Thr Phe Tyr Asn Asn Asn Gln Tyr Asn Gly Tyr Asn Ile Ile 
1               5                   10                  15      


Asn 
    


<210>  122
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  122

Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala 
1               5                   10  


<210>  123
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Thr Lys Glu Tyr Gln Asp Leu Gln His Leu 
1               5                   10      


<210>  124
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  124

Ser Tyr Lys Tyr Ser Lys Val Asn Lys Glu 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  125

Pro Ala Ala Tyr Arg Gly Val Gly Asp Asp 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  126

Thr Gly Val Tyr Val Lys Met Pro Pro Thr 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  127

Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu 
1               5                   10  


<210>  128
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  128

Ala Ser Asp Tyr Gln Arg Leu Asn Leu Lys Leu 
1               5                   10      


<210>  129
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  129

Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
1               5                   10      


<210>  130
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  130

Arg Met Gln Ala Gln Pro Pro Gly Tyr Arg His Val Ala Asp Gly Glu 
1               5                   10                  15      


Asp His Ala 
            


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dileucine-based sorting signal


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Asp or Glu

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Leu or Ile

<400>  131

Xaa Xaa Xaa Xaa Leu Leu Xaa 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  132

Ser Asp Lys Gln Thr Leu Leu Pro Asn 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  133

Asp Glu Arg Ala Pro Leu Ile Arg Thr 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Gln Glu Lys Asp Pro Leu Leu Lys Asn 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Coturnix japonica

<400>  135

Thr Glu Arg Asn Pro Leu Leu Lys Ser 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  136

Gly Glu Asn Ser Pro Leu Leu Ser Gly 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  137

Glu Glu Lys Gln Pro Leu Leu Met Glu 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Oryzias latipes

<400>  138

Gly Glu Arg Gln Pro Leu Leu Gln Ser 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken tyrosinase dileucine-based sorting signal

<400>  139

Pro Glu Ile Gln Pro Leu Leu Thr Glu 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  goldfish TRP-1 dileucine-based sorting signal

<400>  140

Glu Gly Arg Gln Pro Leu Leu Gly Asp 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Glu Ala Asn Gln Pro Leu Leu Thr Asp 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken TRP-1 dileucine-based sorting signal

<400>  142

Glu Leu His Gln Pro Leu Leu Thr Asp 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  zebrafish TRP-2 dileucine-based sorting signal

<400>  143

Arg Glu Phe Glu Pro Leu Leu Asn Ala 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  144

Glu Glu Lys Met Ala Ile Leu Met Asp 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  145

Glu Glu Lys Leu Ala Ile Leu Ser Gln 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  146

Ser Glu Arg Asp Val Leu Leu Asp Glu 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser Glu Arg Arg Asn Leu Leu Glu Asp 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  148

Asp Asp Ser Gly Asp Leu Leu Pro Gly 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  149

Ser Gln Ile Lys Arg Leu Leu Ser Glu 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Felis catus

<400>  150

Ser His Ile Lys Arg Leu Leu Ser Glu 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  151

Arg Arg Thr Pro Ser Leu Leu Glu Gln 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  152

His Arg Thr Pro Ser Leu Leu Glu Gln 
1               5                   


<210>  153
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  153

Glu Pro Arg Gly Ser Arg Leu Leu Val Arg 
1               5                   10  


<210>  154
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
1               5                   10                  15      


Leu Gly Arg 
            


<210>  155
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  155

Met Asp Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Leu Pro Ile 
1               5                   10                  15      


Leu Gly Asn 
            


<210>  156
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken Ii dileucine-based sorting signal

<400>  156

Met Ala Glu Glu Gln Arg Asp Leu Ile Ser Ser Asp Gly Ser Ser Gly 
1               5                   10                  15      


Val Leu Pro Ile 
            20  


<210>  157
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  zebrafish Ii dileucine-based sorting signal

<400>  157

Met Glu Pro Asp His Gln Asn Glu Ser Leu Ile Gln Arg Val Pro Ser 
1               5                   10                  15      


Ala Glu Thr Ile Leu Gly Arg 
            20              


<210>  158
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  zebrafish Ii dileucine-based sorting signal

<400>  158

Met Ser Ser Glu Gly Asn Glu Thr Pro Leu Ile Ser Asp Gln Ser Ser 
1               5                   10                  15      


Val Asn Met Gly Pro Gln Pro 
            20              


<210>  159
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trypanosome Lamp dileucine-based sorting signal

<400>  159

Arg Pro Arg Arg Arg Thr Glu Glu Asp Glu Leu Leu Pro Glu Glu Ala 
1               5                   10                  15      


Glu Gly Leu Ile Asp Pro Gln Asn 
            20                  


<210>  160
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  160

Pro Asp Lys His Ser Leu Leu Val Gly Asp Phe Arg Glu Asp Asp Asp 
1               5                   10                  15      


Thr Ala Leu 
            


<210>  161
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  161

Thr Glu Arg Glu Arg Leu Leu Asn Phe 
1               5                   


<210>  162
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  162

Val Glu Thr Asp Asp Leu Ile Leu 
1               5               


<210>  163
<211>  7
<212>  PRT
<213>  Caenorhabditis elegans

<400>  163

Phe Glu Asn Asp Ser Leu Leu 
1               5           


<210>  164
<211>  9
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  164

Asn Glu Gln Ser Pro Leu Leu His Asn 
1               5                   


<210>  165
<211>  8
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  165

Ser Glu Gln Thr Arg Leu Val Pro 
1               5               


<210>  166
<211>  8
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  166

Glu Val Asp Leu Asp Leu Leu Lys 
1               5               


<210>  167
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dileucine-based sorting signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  167

Asp Xaa Xaa Leu Leu 
1               5   


<210>  168
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  168

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Ile 
1               5                   10              


<210>  169
<211>  13
<212>  PRT
<213>  Bos taurus

<400>  169

Thr Phe His Asp Asp Ser Asp Glu Asp Leu Leu His Val 
1               5                   10              


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rabbit CI-MPR dileucine-based sorting signal

<400>  170

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu Asn Ile 
1               5                   10              


<210>  171
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken CI-MPR dileucine-based sorting signal

<400>  171

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu Asn Val 
1               5                   10              


<210>  172
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  172

Glu Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
1               5                   10              


<210>  173
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chicken CD-MPR dileucine-based sorting signal

<400>  173

Asp Glu Ser Glu Glu Arg Asp Asp His Leu Leu Pro Met 
1               5                   10              


<210>  174
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  174

Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
1               5                   10          


<210>  175
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  175

Ile Thr Gly Phe Ser Asp Asp Val Pro Met Val Ile Ala 
1               5                   10              


<210>  176
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydra Head-activator BP dileucine-based sorting signal

<400>  176

Ile Asn Arg Phe Ser Asp Asp Glu Pro Leu Val Val Ala 
1               5                   10              


<210>  177
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Leu Glu Ala Ser Asp Asp Glu Ala Leu Leu Val Cys 
1               5                   10              


<210>  178
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  178

Lys Asn Glu Thr Ser Asp Asp Glu Ala Leu Leu Leu Cys 
1               5                   10              


<210>  179
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  179

Trp Val Val Glu Ala Glu Asp Glu Pro Leu Leu Ala 
1               5                   10          


<210>  180
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  180

Trp Val Ala Glu Ala Glu Asp Glu Pro Leu Leu Thr 
1               5                   10          


<210>  181
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  181

His Asp Asp Phe Ala Asp Asp Ile Ser Leu Leu Lys 
1               5                   10          


<210>  182
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  182

Gly Arg Asp Ser Pro Glu Asp His Ser Leu Leu Val Asn 
1               5                   10              


<210>  183
<211>  12
<212>  PRT
<213>  Peromyscus maniculatus

<400>  183

Val Arg Cys His Pro Glu Asp Asp Arg Leu Leu Gly 
1               5                   10          


<210>  184
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  184

His Arg Val Ser Gln Asp Asp Leu Asp Leu Leu Thr Ser 
1               5                   10              


<210>  185
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  185

Ala Ser Val Ser Leu Leu Asp Asp Glu Leu Met Ser Leu 
1               5                   10              


<210>  186
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  186

Ala Ser Ser Gly Leu Asp Asp Leu Asp Leu Leu Gly Lys 
1               5                   10              


<210>  187
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  187

Val Gln Asn Pro Ser Ala Asp Arg Asn Leu Leu Asp Leu 
1               5                   10              


<210>  188
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  188

Asn Ala Leu Ser Trp Leu Asp Glu Glu Leu Leu Cys Leu 
1               5                   10              


<210>  189
<211>  13
<212>  PRT
<213>  Drosophila sp.

<400>  189

Thr Val Asp Ser Ile Asp Asp Val Pro Leu Leu Ser Asp 
1               5                   10              


<210>  190
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  190

Gln Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly 
1               5                   10              


<210>  191
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  191

Arg Asp Arg Asp Tyr Asp Glu Asp Asp Glu Asp Asp Ile 
1               5                   10              


<210>  192
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  192

Leu Asp Glu Thr Glu Asp Asp Glu Leu Glu Tyr Asp Asp Glu Ser 
1               5                   10                  15  


<210>  193
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  193

Lys Asp Pro Asp Glu Val Glu Thr Glu Ser 
1               5                   10  


<210>  194
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  194

His Glu Phe Gln Asp Glu Thr Asp Thr Glu Glu Glu Thr 
1               5                   10              


<210>  195
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  195

Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr 
1               5                   10                  


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VMAT1 acidic cluster sorting signal

<400>  196

Gly Glu Asp Glu Glu Ser Glu Ser Asp 
1               5                   


<210>  197
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VAMP4 acidic cluster sorting signal

<400>  197

Gly Glu Asp Ser Asp Glu Glu Pro Asp His Glu Glu 
1               5                   10          


<210>  198
<211>  13
<212>  PRT
<213>  Herpes virus 3

<400>  198

Phe Glu Asp Ser Glu Ser Thr Asp Thr Glu Glu Glu Phe 
1               5                   10              


<210>  199
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  199

Leu Glu Ala Gln Glu Glu Glu Glu Val 
1               5                   


<210>  200
<211>  22
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  200

Ala Asp Asp Leu Glu Ser Gly Leu Gly Ala Glu Asp Asp Leu Glu Gln 
1               5                   10                  15      


Asp Glu Gln Leu Glu Gly 
            20          


<210>  201
<211>  12
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  201

Thr Glu Ile Asp Glu Ser Phe Glu Met Thr Asp Phe 
1               5                   10          


<210>  202
<211>  18
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  202

Thr Glu Pro Glu Glu Val Glu Asp Phe Asp Phe Asp Leu Ser Asp Glu 
1               5                   10                  15      


Asp His 
        


<210>  203
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  203

Phe Glu Ile Glu Glu Asp Asp Val Pro Thr Leu Glu Glu Glu His 
1               5                   10                  15  


<210>  204
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Asp or Glu

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Leu or Ile

<400>  204

Xaa Xaa Xaa Xaa Leu Xaa 
1               5       


<210>  205
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Phe or Trp

<400>  205

Asp Pro Xaa 
1           


<210>  206
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  206

Phe Xaa Asp Xaa Phe 
1               5   


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is an amino acid with a bulky hydrophobic side chain

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be Asp or Glu

<400>  207

Leu Xaa Xaa Xaa Xaa 
1               5   


<210>  208
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  208

Leu Leu Asp Leu Leu 
1               5   


<210>  209
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  209

Pro Trp Asp Leu Trp 
1               5   


<210>  210
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular retention signal

<400>  210

His Asp Glu Leu 
1               


<210>  211
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  membrane proximal buffer sequence

<400>  211

Lys Pro Asp Lys 
1               


<210>  212
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  membrane-bound DcR3: sequence:human DcR3-CD8 stalk/TM/rigid 
       linker

<400>  212

Met Glu Thr Asp Thr Leu Ile Leu Trp Val Leu Leu Leu Leu Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Val Ala Glu Thr Pro Thr Tyr Pro Trp Arg Asp Ala 
            20                  25                  30          


Glu Thr Gly Glu Arg Leu Val Cys Ala Gln Cys Pro Pro Gly Thr Phe 
        35                  40                  45              


Val Gln Arg Pro Cys Arg Arg Asp Ser Pro Thr Thr Cys Gly Pro Cys 
    50                  55                  60                  


Pro Pro Arg His Tyr Thr Gln Phe Trp Asn Tyr Leu Glu Arg Cys Arg 
65                  70                  75                  80  


Tyr Cys Asn Val Leu Cys Gly Glu Arg Glu Glu Glu Ala Arg Ala Cys 
                85                  90                  95      


His Ala Thr His Asn Arg Ala Cys Arg Cys Arg Thr Gly Phe Phe Ala 
            100                 105                 110         


His Ala Gly Phe Cys Leu Glu His Ala Ser Cys Pro Pro Gly Ala Gly 
        115                 120                 125             


Val Ile Ala Pro Gly Thr Pro Ser Gln Asn Thr Gln Cys Gln Pro Cys 
    130                 135                 140                 


Pro Pro Gly Thr Phe Ser Ala Ser Ser Ser Ser Ser Glu Gln Cys Gln 
145                 150                 155                 160 


Pro His Arg Asn Cys Thr Ala Leu Gly Leu Ala Leu Asn Val Pro Gly 
                165                 170                 175     


Ser Ser Ser His Asp Thr Leu Cys Thr Ser Cys Thr Gly Phe Pro Leu 
            180                 185                 190         


Ser Thr Arg Val Pro Gly Ala Glu Glu Cys Glu Arg Ala Val Ile Asp 
        195                 200                 205             


Phe Val Ala Phe Gln Asp Ile Ser Ile Lys Arg Leu Gln Arg Leu Leu 
    210                 215                 220                 


Gln Ala Leu Glu Ala Pro Glu Gly Trp Gly Pro Thr Pro Arg Ala Gly 
225                 230                 235                 240 


Arg Ala Ala Leu Gln Leu Lys Leu Arg Arg Arg Leu Thr Glu Leu Leu 
                245                 250                 255     


Gly Ala Gln Asp Gly Ala Leu Leu Val Arg Leu Leu Gln Ala Leu Arg 
            260                 265                 270         


Val Ala Arg Met Pro Gly Leu Glu Arg Ser Val Arg Glu Arg Phe Leu 
        275                 280                 285             


Pro Val His Ser Asp Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    290                 295                 300                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
305                 310                 315                 320 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                325                 330                 335     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            340                 345                 350         


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Lys Lys Arg Ser 
        355                 360                 365             


Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
    370                 375                 380                 


Ala Lys Glu Ala Ala Ala Lys Ala Leu Glu 
385                 390                 


<210>  213
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bicistronic construct co-expressing an anti-Fas KDEL with FasL: 
       Anti-Fas-KDEL-2A-FasL

<400>  213

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys 
    50                  55                  60                  


Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Ile Cys Ala Val Tyr Gly Gly Ser Phe Ser Thr Tyr Tyr 
                165                 170                 175     


Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Thr Thr Asn Tyr Ser Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn His Ile Ser Leu Asn 
    210                 215                 220                 


Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Trp Ile Gly Glu Gly Asp Tyr Gly Leu Asp Val Trp Gly 
                245                 250                 255     


Gln Gly Thr Thr Val Thr Val Ser Ser Asp Pro Ala Glu Pro Ser Glu 
            260                 265                 270         


Lys Asp Glu Leu Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
        275                 280                 285             


Glu Glu Asn Pro Gly Pro Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro 
    290                 295                 300                 


Gln Ile Tyr Trp Val Asp Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro 
305                 310                 315                 320 


Gly Thr Val Leu Pro Cys Pro Thr Ser Val Pro Arg Arg Pro Gly Gln 
                325                 330                 335     


Arg Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro 
            340                 345                 350         


Pro Pro Pro Pro Leu Pro Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg 
        355                 360                 365             


Gly Asn His Ser Thr Gly Leu Cys Leu Leu Val Met Phe Phe Met Val 
    370                 375                 380                 


Leu Val Ala Leu Val Gly Leu Gly Leu Gly Met Phe Gln Leu Phe His 
385                 390                 395                 400 


Leu Gln Lys Glu Leu Ala Glu Leu Arg Glu Ser Thr Ser Gln Met His 
                405                 410                 415     


Thr Ala Ser Ser Leu Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro 
            420                 425                 430         


Glu Lys Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn 
        435                 440                 445             


Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu 
    450                 455                 460                 


Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr 
465                 470                 475                 480 


Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys 
                485                 490                 495     


Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr 
            500                 505                 510         


Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr 
        515                 520                 525             


Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn 
    530                 535                 540                 


Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu 
545                 550                 555                 560 


Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
                565                 570                 575 


