                         SEQUENCE LISTING

<110>  Autolus Limited
 
<120>  CELL

<130>  P120118PCT

<140>  PCT/GB2021/050862
<141>  2021-04-08

<150>  GB 2005216.3
<151>  2020-04-08

<160>  133   

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cartilage-oligomeric matrix protein (COMP) spacer

<400>  1

Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr 
            20                  25                  30          


Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain (VH) complementarity determining region 
       (CDR), VH CDR1

<400>  2

Gly Tyr Thr Phe Thr Gly Tyr 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  3

Asn Pro Tyr Asn Asp Asp 
1               5       


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  4

Gly Ala Gly Tyr Asn Phe Asp Gly Ala Tyr Arg Phe Phe Asp Phe 
1               5                   10                  15  


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain (VL) CDR, VL CDR1

<400>  5

Arg Ser Ser Gln Arg Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  6

Arg Val Ser Asn Arg Phe Pro 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  7

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  8
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJovi-1 variable heavy chain (VH)

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Asn Pro Tyr Asn Asp Asp Ile Gln Ser Asn Glu Arg Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Asn Phe Asp Gly Ala Tyr Arg Phe Phe Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJovi-1 variable light chain (VL)

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Jovi-1 single-chain variable fragment (scFv)

<400>  10

Glu Val Arg Leu Gln Gln Ser Gly Pro Asp Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Tyr Asn Asp Asp Ile Gln Ser Asn Glu Arg Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Asn Phe Asp Gly Ala Tyr Arg Phe Phe Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
    130                 135                 140                 


Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
145                 150                 155                 160 


Ser Cys Arg Ser Ser Gln Arg Leu Val His Ser Asn Gly Asn Thr Tyr 
                165                 170                 175     


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Arg Val Ser Asn Arg Phe Pro Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
    210                 215                 220                 


Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
                245                 250         


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide bridge comprising the 13 membrane proximal amino acids of
       the extracellular portion of HLA-A2

<400>  11

Leu Arg Trp Glu Pro Ser Ser Asn Pro Thr Ile Pro Ile 
1               5                   10              


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  12

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  13
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  13

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210>  14
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  15
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
1               5                   10                  15      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            20                  25                  30          


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
        35                  40                  45              


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    50                  55                  60                  


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
65                  70                  75                  80  


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                85                  90                  95      


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 


<210>  16
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A01, amino acid sequence of HLA class I

<400>  16

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  17
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A02, amino acid sequence of HLA class I

<400>  17

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  18
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A-A03, amino acid sequence of HLA class I

<400>  18

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  19
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B07, amino acid sequence of HLA class I

<400>  19

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  20
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B08, amino acid sequence of HLA class I

<400>  20

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Phe Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Asp Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Thr Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  21
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B44, amino acid sequence of HLA class I

<400>  21

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ala Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Thr Ser Pro Arg Lys Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Ser Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Tyr Arg Glu Asn Leu Arg Thr Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Ile Ile Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Asp Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Ser Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Val Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  22
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C01, amino acid sequence of HLA class I

<400>  22

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Lys Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met Cys Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu His 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Trp Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Met 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Ala Val Val Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Ser Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Ala Cys Lys Ala 
        355                 360                 365     


<210>  23
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  24
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Thr Ser Pro Arg Lys Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Ser Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Tyr Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  25
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr Ala 
1               5                   10                  15      


Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr Pro 
            20                  25                  30          


Glu Asn Tyr Val His Gln Leu Arg Gln Glu Cys Tyr Gly Phe Asn Gly 
        35                  40                  45              


Thr Gln Arg Phe Leu Glu Ser Tyr Ile Tyr Asn Arg Glu Glu Phe Val 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu Gly 
65                  70                  75                  80  


Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu Glu 
                85                  90                  95      


Glu Arg Ala Val Pro Asp Arg Val Cys Arg Arg Asn Tyr Glu Leu Asp 
            100                 105                 110         


Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val Ser 
        115                 120                 125             


Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys His 
    130                 135                 140                 


Val Thr Asp Phe Tyr Pro Ser Ser Ile Gln Val Arg Trp Phe Leu Asn 
145                 150                 155                 160 


Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro Gln 
            180                 185                 190         


Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp Ser 
        195                 200                 205             


Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Gln Ser Lys 
    210                 215                 220                 


Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys Gly 
225                 230                 235                 240 


Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly Ser 
                245                 250                 255     


Ala 
    


<210>  26
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala Thr 
1               5                   10                  15      


Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly Arg 
            20                  25                  30          


Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr Phe 
        35                  40                  45              


Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr Asn 
    50                  55                  60                  


Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg Ala 
65                  70                  75                  80  


Val Thr Pro Gln Gly Arg Pro Val Ala Glu Tyr Trp Asn Ser Gln Lys 
                85                  90                  95      


Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg His 
            100                 105                 110         


Asn Tyr Glu Val Gly Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu Pro 
        115                 120                 125             


Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn 
    130                 135                 140                 


Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys Val 
145                 150                 155                 160 


Gln Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr 
                165                 170                 175     


Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Met Leu Glu 
            180                 185                 190         


Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu His Pro 
        195                 200                 205             


Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu Ser 
    210                 215                 220                 


Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu 
225                 230                 235                 240 


Ile Phe Leu Gly Leu Gly Leu Ile Ile 
                245                 


<210>  27
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  28
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210>  29
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  30
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  31
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  32
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  33

Ser Gly Gly Gly Gly 
1               5   


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  34

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  35
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from HLA-DRalpha, a
       transmembrane domain and an intracellular CD3-zeta endodomain

<400>  35

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
            20                  25                  30          


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
        35                  40                  45              


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
    50                  55                  60                  


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
65                  70                  75                  80  


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
                85                  90                  95      


Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu 
            100                 105                 110         


Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe 
        115                 120                 125             


Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn 
    130                 135                 140                 


Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg 
145                 150                 155                 160 


Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser 
                165                 170                 175     


Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu 
            180                 185                 190         


Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu 
        195                 200                 205             


Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu Thr Val Gly Leu Val 
    210                 215                 220                 


Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Arg Val Lys Phe Ser Arg 
225                 230                 235                 240 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                245                 250                 255     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            260                 265                 270         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala 
            340                 345         


<210>  36
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from HLA-DRalpha, a
       transmembrane domain, a 41BB endodomain and an intracellular 
       CD3-zeta endodomain.

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
            20                  25                  30          


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
        35                  40                  45              


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
    50                  55                  60                  


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
65                  70                  75                  80  


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
                85                  90                  95      


Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu 
            100                 105                 110         


Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe 
        115                 120                 125             


Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn 
    130                 135                 140                 


Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg 
145                 150                 155                 160 


Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser 
                165                 170                 175     


Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu 
            180                 185                 190         


Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu 
        195                 200                 205             


Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu Thr Val Gly Leu Val 
    210                 215                 220                 


Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys Arg Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                245                 250                 255     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            260                 265                 270         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        275                 280                 285             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    290                 295                 300                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
305                 310                 315                 320 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                325                 330                 335     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            340                 345                 350         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        355                 360                 365             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    370                 375                 380                 


Leu Pro Pro Arg Ala 
385                 


<210>  37
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from HLA-DRalpha, a
       transmembrane domain, a CD28 endodomain and an intracellular 
       CD3-zeta endodomain

<400>  37

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe 
            20                  25                  30          


Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly 
        35                  40                  45              


Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg 
    50                  55                  60                  


Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu 
65                  70                  75                  80  


Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg 
                85                  90                  95      


Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu 
            100                 105                 110         


Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe 
        115                 120                 125             


Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn 
    130                 135                 140                 


Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg 
145                 150                 155                 160 


Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser 
                165                 170                 175     


Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu 
            180                 185                 190         


Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu 
        195                 200                 205             


Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu Thr Val Gly Leu Val 
    210                 215                 220                 


Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Arg Ser Lys Arg Ser Arg 
225                 230                 235                 240 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                245                 250                 255     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            260                 265                 270         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        275                 280                 285             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    290                 295                 300                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
305                 310                 315                 320 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                325                 330                 335     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            340                 345                 350         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        355                 360                 365             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    370                 375                 380                 


Pro Pro Arg Ala 
385             


<210>  38
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from CD79alpha, a 
       41BB domain and an endodomain from CD79

<400>  38

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val 
            20                  25                  30          


Ser Leu Gly Glu Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn 
        35                  40                  45              


Asn Ala Asn Val Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp 
    50                  55                  60                  


Pro Pro Glu Phe Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile 
65                  70                  75                  80  


Ile Gln Asn Val Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val 
                85                  90                  95      


Gln Glu Gly Asn Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg 
            100                 105                 110         


Val Arg Gln Pro Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr 
        115                 120                 125             


Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala 
    130                 135                 140                 


Val Val Pro Gly Thr Leu Leu Leu Phe Lys Arg Gly Arg Lys Lys Leu 
145                 150                 155                 160 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                165                 170                 175     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            180                 185                 190         


Cys Glu Leu Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala 
        195                 200                 205             


Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp 
    210                 215                 220                 


Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr 
225                 230                 235                 240 


Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
                245                 250                 255     


<210>  39
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from CD79beta, a 
       CD28 domain and an endodomain from CD79

<400>  39

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly 
            20                  25                  30          


Ser Ala Cys Ser Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Phe Thr Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly 
    50                  55                  60                  


Asn Val Ser Trp Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln 
65                  70                  75                  80  


Leu Lys Leu Glu Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu 
                85                  90                  95      


Ala Thr Leu Thr Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr 
            100                 105                 110         


Phe Cys Gln Gln Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly Cys 
        115                 120                 125             


Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu Ala Gln Leu Lys 
    130                 135                 140                 


Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu 
145                 150                 155                 160 


Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Arg Ser Lys Arg 
                165                 170                 175     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            180                 185                 190         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        195                 200                 205             


Ala Ala Tyr Arg Ser Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu 
    210                 215                 220                 


Glu Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr 
225                 230                 235                 240 


Glu Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly 
                245                 250                 255     


Glu His Pro Gly Gln Glu 
            260         


<210>  40
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from CD79alpha, a 
       CD28 domain and an endodomain from CD79

<400>  40

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val 
            20                  25                  30          


Ser Leu Gly Glu Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn 
        35                  40                  45              


Asn Ala Asn Val Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp 
    50                  55                  60                  


Pro Pro Glu Phe Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile 
65                  70                  75                  80  


Ile Gln Asn Val Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val 
                85                  90                  95      


Gln Glu Gly Asn Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg 
            100                 105                 110         


Val Arg Gln Pro Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr 
        115                 120                 125             


Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala 
    130                 135                 140                 


Val Val Pro Gly Thr Leu Leu Leu Phe Arg Ser Lys Arg Ser Arg Leu 
145                 150                 155                 160 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                165                 170                 175     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            180                 185                 190         


Arg Ser Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly 
        195                 200                 205             


Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp 
    210                 215                 220                 


Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln 
225                 230                 235                 240 


Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
                245                 250                 255 


<210>  41
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from CD79beta, a 
       41BB domain and an endodomain from CD79

<400>  41

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly 
            20                  25                  30          


Ser Ala Cys Ser Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Phe Thr Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly 
    50                  55                  60                  


Asn Val Ser Trp Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln 
65                  70                  75                  80  


Leu Lys Leu Glu Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu 
                85                  90                  95      


Ala Thr Leu Thr Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr 
            100                 105                 110         


Phe Cys Gln Gln Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly Cys 
        115                 120                 125             


Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu Ala Gln Leu Lys 
    130                 135                 140                 


Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu 
145                 150                 155                 160 


Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Lys Arg Gly Arg 
                165                 170                 175     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            180                 185                 190         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        195                 200                 205             


Glu Gly Gly Cys Glu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met 
    210                 215                 220                 


Glu Glu Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr 
225                 230                 235                 240 


Tyr Glu Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val 
                245                 250                 255     


Gly Glu His Pro Gly Gln Glu 
            260             


<210>  42
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from CD79alpha, a 
       41BB domain and a CD3-zeta domain

<400>  42

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val 
            20                  25                  30          


Ser Leu Gly Glu Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn 
        35                  40                  45              


Asn Ala Asn Val Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp 
    50                  55                  60                  


Pro Pro Glu Phe Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile 
65                  70                  75                  80  


Ile Gln Asn Val Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val 
                85                  90                  95      


Gln Glu Gly Asn Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg 
            100                 105                 110         


Val Arg Gln Pro Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr 
        115                 120                 125             


Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala 
    130                 135                 140                 


Val Val Pro Gly Thr Leu Leu Leu Phe Lys Arg Gly Arg Lys Lys Leu 
145                 150                 155                 160 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                165                 170                 175     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            180                 185                 190         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        195                 200                 205             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    210                 215                 220                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
225                 230                 235                 240 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                245                 250                 255     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            260                 265                 270         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        275                 280                 285             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    290                 295                 300                 


Pro Pro Arg Ala 
305             


<210>  43
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence comprising an ectodomain from CD79beta, a 
       41BB domain and a CD3-zeta domain

<400>  43

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly 
            20                  25                  30          


Ser Ala Cys Ser Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Phe Thr Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly 
    50                  55                  60                  


Asn Val Ser Trp Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln 
65                  70                  75                  80  


Leu Lys Leu Glu Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu 
                85                  90                  95      


Ala Thr Leu Thr Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr 
            100                 105                 110         


Phe Cys Gln Gln Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly Cys 
        115                 120                 125             


Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu Ala Gln Leu Lys 
    130                 135                 140                 


Gln Arg Asn Thr Leu Lys Asp Ile Ile Thr Ala Glu Gly Ile Ile Leu 
145                 150                 155                 160 


Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Lys Arg Gly 
                165                 170                 175     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            180                 185                 190         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        195                 200                 205             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    210                 215                 220                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
225                 230                 235                 240 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                245                 250                 255     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            260                 265                 270         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        275                 280                 285             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    290                 295                 300                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
305                 310                 315                 320 


Met Gln Ala Leu Pro Pro Arg Ala 
                325             


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta endodomain

<400>  44

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  45
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB and CD3-zeta endodomains

<400>  45

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                245                 250                 255     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  46
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 and CD3-zeta endodomains

<400>  46

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
        35                  40                  45              


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
65                  70                  75                  80  


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            100                 105                 110         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        115                 120                 125             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    130                 135                 140                 


His Met Gln Ala Leu Pro Pro Arg 
145                 150         


<210>  47
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28, OX40 and CD3-zeta endodomains

<400>  47

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short flexible linker

<400>  48

Ser Gly Gly Gly Ser Asp Pro 
1               5           


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  serine-glycine linker

<400>  49

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  50
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 D1 domain

<400>  50

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu 
            100 


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha Ig-like V-type domain

<400>  51

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala 
        


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide spacer repeating unit

<400>  52

Gly Gly Gly Gly Ser 
1               5   


<210>  53
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha alpha homodimer

<400>  53

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Gln Phe Arg Val Ser Pro Leu Asp Arg 
    130                 135                 140                 


Thr Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu 
145                 150                 155                 160 


Ser Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala 
                165                 170                 175     


Ala Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys 
            180                 185                 190         


Ala Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly 
        195                 200                 205             


Asp Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly 
    210                 215                 220                 


Tyr Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His 
225                 230                 235                 240 


Phe Val Pro Val Phe Leu Pro Ala 
                245             


<210>  54
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8beta Ig-like V-type domain

<400>  54

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu 
            100                 105                 110     


<210>  55
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence, second binding domain

<400>  55

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 heavy chain CDR1

<400>  56

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 heavy chain CDR2

<400>  57

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 heavy chain CDR3

<400>  58

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 light chain CDR1

<400>  59

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 light chain CDR2

<400>  60

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 light chain CDR3

<400>  61

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  62
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence, second binding domain

<400>  62

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Ser Ser Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        115                 120                 125             


Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
145                 150                 155                 160 


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
                165                 170                 175     


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys 
            180                 185                 190         


Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
        195                 200                 205             


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr 
    210                 215                 220                 


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  63
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, IgG1 hinge

<400>  63

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  64
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, CD8 stalk

<400>  64

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  65
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  calcineurin A, alpha isoform

<400>  65

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  66
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  calcineurin B, type 1

<400>  66

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  67
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  68
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dominant negative C-terminal Src kinase (dnCSK) sequence, 
       wild-type CSK sequence minus kinase domain (CSK_del_kinase)

<400>  68

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu 
        


<210>  69
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnCSK sequence, wild-type CSK sequence minus kinase and SH3 
       domains (CSK_del_kinase_SH3)

<400>  69

Met Ser Ala Ile Gln Ala Ala Trp Val Lys Ala Gly Thr Lys Leu Ser 
1               5                   10                  15      


Leu Met Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg 
            20                  25                  30          


Leu Leu Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr 
        35                  40                  45              


Asn Tyr Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val 
    50                  55                  60                  


Glu His Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu 
65                  70                  75                  80  


Glu Val Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser 
                85                  90                  95      


Asp Ala Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu 
            100                 105                 110         


Gly Thr Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu 
        115                 120                 125             


Asn Met Lys Glu 
    130         


<210>  70
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnCSK sequence, full length CSK sequence with a K222R 
       substitution (CSK(K222R))

<400>  70

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Arg Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  71
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnCSK sequence, mutated CSK comprising mutation T266G and SH3 
       domain deleted

<400>  71

Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala 
1               5                   10                  15      


Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys 
            20                  25                  30          


Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr 
        35                  40                  45              


Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr 
    50                  55                  60                  


Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met 
65                  70                  75                  80  


Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu 
                85                  90                  95      


Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr 
            100                 105                 110         


Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His 
        115                 120                 125             


Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val 
    130                 135                 140                 


Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala 
145                 150                 155                 160 


Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr 
                165                 170                 175     


Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met 
            180                 185                 190         


Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp 
        195                 200                 205             


Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile 
    210                 215                 220                 


Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met 
225                 230                 235                 240 


Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val 
                245                 250                 255     


Glu Glu Lys Gly Gly Leu Tyr Ile Val Gly Glu Tyr Met Ala Lys Gly 
            260                 265                 270         


Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly 
        275                 280                 285             


Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr 
    290                 295                 300                 


Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val 
305                 310                 315                 320 


Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr 
                325                 330                 335     


Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp 
            340                 345                 350         


Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp 
        355                 360                 365             


Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg 
    370                 375                 380                 


Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu 
385                 390                 395                 400 


Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr 
                405                 410                 415     


Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser 
            420                 425                 430         


Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu 
        435                 440                 445             


His Leu 
    450 


<210>  72
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  73
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala 
        


<210>  74
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  74

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  75
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  75

Thr His Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala 
1               5                   10                  15      


Leu Thr Phe Ile Phe 
            20      


<210>  76
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  77
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala 
            


<210>  78
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu Lys 
            100                 105                 110         


Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly Tyr 
        115                 120                 125             


Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn Thr 
    130                 135                 140                 


Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val Leu 
145                 150                 155                 160 


Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp Asn 
                165                 170                 175     


Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser Gln 
            180                 185                 190         


Met Glu Pro Arg Thr His Pro Thr 
        195                 200 


<210>  79
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  79

Trp Leu Leu His Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe 
1               5                   10                  15      


Ile Ala Thr Val Ile 
            20      


<210>  80
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  81
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala 
        35              


<210>  82
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  82

Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro Val Gly Ser Glu Cys Cys 
1               5                   10                  15      


Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu 
            20                  25                  30          


Thr Gly Thr Val Cys Glu Pro Cys Pro Pro Gly Thr Tyr Ile Ala His 
        35                  40                  45              


Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys Gln Met Cys Asp Pro Ala 
    50                  55                  60                  


Met Gly Leu Arg Ala Ser Arg Asn Cys Ser Arg Thr Glu Asn Ala Val 
65                  70                  75                  80  


Cys Gly Cys Ser Pro Gly His Phe Cys Ile Val Gln Asp Gly Asp His 
                85                  90                  95      


Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser Ser Pro Gly Gln Arg Val 
            100                 105                 110         


Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr Leu Cys Gln Asn Cys Pro 
        115                 120                 125             


Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu Glu Glu Cys Gln His Gln 
    130                 135                 140                 


Thr Lys Cys Ser Trp Leu Val Thr Lys Ala Gly Ala Gly Thr Ser Ser 
145                 150                 155                 160 


Ser His Trp Val 
                


<210>  83
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  83

Trp Trp Phe Leu Ser Gly Ser Leu Val Ile Val Ile Val Cys Ser Thr 
1               5                   10                  15      


Val Gly Leu Ile 
            20  


<210>  84
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  85
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser 
            20  


<210>  86
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  86

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  87
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Ile Ile Phe Leu Val Leu Gly Ile Leu Val Phe Leu Ile Leu Leu 
1               5                   10                  15      


Gly Ile Gly Ile Tyr Phe Tyr Trp 
            20                  


<210>  88
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile 
225                 230                 235                 240 


Gly Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe 
                245                 250                 255     


Cys Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp 
        275                 280                 285             


Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser 
    290                 295                 300                 


Ser Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg 
305                 310                 315                 320 


Tyr Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser 
                325                 330                 335     


His Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala 
            340                 345                 350         


Asn Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln 
        355                 360                 365             


His Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val 
    370                 375                 380                 


Met Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His 
385                 390                 395                 400 


Thr His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala 
                405                 410                 415     


Val Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430     


<210>  89
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser 
            20          


<210>  90
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  90

Leu Glu Val Ser Glu Ser Pro Gly Ser Ile Gln Val Ala Arg Gly Gln 
1               5                   10                  15      


Pro Ala Val Leu Pro Cys Thr Phe Thr Thr Ser Ala Ala Leu Ile Asn 
            20                  25                  30          


Leu Asn Val Ile Trp Met Val Thr Pro Leu Ser Asn Ala Asn Gln Pro 
        35                  40                  45              


Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln Met Phe Asp Gly Ala Pro 
    50                  55                  60                  


Arg Phe His Gly Arg Val Gly Phe Thr Gly Thr Met Pro Ala Thr Asn 
65                  70                  75                  80  


Val Ser Ile Phe Ile Asn Asn Thr Gln Leu Ser Asp Thr Gly Thr Tyr 
                85                  90                  95      


Gln Cys Leu Val Asn Asn Leu Pro Asp Ile Gly Gly Arg Asn Ile Gly 
            100                 105                 110         


Val Thr Gly Leu Thr Val Leu Val Pro Pro Ser Ala Pro His Cys Gln 
        115                 120                 125             


Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp Val Ile Leu Leu Cys Ser 
    130                 135                 140                 


Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr Leu Trp Glu Lys Leu Asp 
145                 150                 155                 160 


Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr Gln Asp Gln Val Gln Gly 
                165                 170                 175     


Thr Val Thr Ile Arg Asn Ile Ser Ala Leu Ser Ser Gly Leu Tyr Gln 
            180                 185                 190         


Cys Val Ala Ser Asn Ala Ile Gly Thr Ser Thr Cys Leu Leu Asp Leu 
        195                 200                 205             


Gln Val Ile Ser Pro Gln Pro Arg Asn Ile Gly 
    210                 215                 


<210>  91
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe Cys 
1               5                   10                  15      


Ile Ala Leu Ile Leu 
            20      


<210>  92
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  93
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


<210>  94
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  94

Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
1               5                   10                  15      


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
            20                  25                  30          


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
        35                  40                  45              


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
    50                  55                  60                  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
65                  70                  75                  80  


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
                85                  90                  95      


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
            100                 105                 110         


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
        115                 120                 125             


Ile Ser Phe Gln 
    130         


<210>  95
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  95

Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser Ile Leu 
1               5                   10                  15      


Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile Asn Leu 
            20                  25                  30          


Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu 
        35                  40                  45              


Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly Ser Glu 
    50                  55                  60                  


Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln Ser Phe 
65                  70                  75                  80  


Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala Val Asp 
                85                  90                  95      


Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu Pro Thr 
            100                 105                 110         


Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His Val Gln 
        115                 120                 125             


Thr 
    


<210>  96
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  97
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala 
            20                  


<210>  98
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  98

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu 
            260                 265                 270         


Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile 
        275                 280                 


<210>  99
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly 
1               5                   10                  15      


Ala Ala Val Ala Ala Val Leu Trp 
            20                  


<210>  100
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  101
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala 
        


<210>  102
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  102

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly 
385                 390                 


<210>  103
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  103

Ala Ile Ala Gly Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile 
1               5                   10                  15      


Ala Val Ala Leu Ala Cys Phe 
            20              


<210>  104
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Asp Thr Thr Arg Tyr Ser Lys Trp Gly Gly Ser Ser Glu Glu Val 
1               5                   10                  15      


Pro Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro Leu 
            20                  25                  30          


Phe Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val Ile 
        35                  40                  45              


Leu Ser Ile Leu Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu 
    50                  55                  60                  


Asp Gly His Asp Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala 
65                  70                  75                  80  


Leu Gly Ala Leu Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser 
                85                  90                  95      


Gly Thr Gln Ala Gln Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala 
            100                 105                 110         


Gln Ala Lys Leu Met Glu Gln Glu Ser Ala Leu Arg Glu Leu Arg Glu 
        115                 120                 125             


Arg Val Thr Gln Gly Leu Ala Glu Ala Gly Arg Gly Arg Glu Asp Val 
    130                 135                 140                 


Arg Thr Glu Leu Phe Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Asn 
145                 150                 155                 160 


Ser Cys Glu Pro Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly Ser Cys 
                165                 170                 175     


Tyr Phe Phe Ser Val Pro Lys Thr Thr Trp Ala Ala Ala Gln Asp His 
            180                 185                 190         


Cys Ala Asp Ala Ser Ala His Leu Val Ile Val Gly Gly Leu Asp Glu 
        195                 200                 205             


Gln Gly Phe Leu Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp Leu Gly 
    210                 215                 220                 


Leu Arg Ala Val Arg His Leu Gly Lys Val Gln Gly Tyr Gln Trp Val 
225                 230                 235                 240 


Asp Gly Val Ser Leu Ser Phe Ser His Trp Asn Gln Gly Glu Pro Asn 
                245                 250                 255     


Asp Ala Trp Gly Arg Glu Asn Cys Val Met Met Leu His Thr Gly Leu 
            260                 265                 270         


Trp Asn Asp Ala Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile Cys Glu 
        275                 280                 285             


Lys Arg His Asn Cys 
    290             


<210>  105
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Asp Thr Thr Arg Tyr Ser Lys Trp Gly Gly Ser Ser Glu Glu Val 
1               5                   10                  15      


Pro Gly Gly Pro Trp Gly Arg Trp Val His Trp Ser Arg Arg Pro 
            20                  25                  30      


<210>  106
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  106

Leu Phe Leu Ala Leu Ala Val Leu Val Thr Thr Val Leu Trp Ala Val 
1               5                   10                  15      


Ile Leu Ser Ile Leu 
            20      


<210>  107
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  107

Leu Ser Lys Ala Ser Thr Glu Arg Ala Ala Leu Leu Asp Gly His Asp 
1               5                   10                  15      


Leu Leu Arg Thr Asn Ala Ser Lys Gln Thr Ala Ala Leu Gly Ala Leu 
            20                  25                  30          


Lys Glu Glu Val Gly Asp Cys His Ser Cys Cys Ser Gly Thr Gln Ala 
        35                  40                  45              


Gln Leu Gln Thr Thr Arg Ala Glu Leu Gly Glu Ala Gln Ala Lys Leu 
    50                  55                  60                  


Met Glu Gln Glu Ser Ala Leu Arg Glu Leu Arg Glu Arg Val Thr Gln 
65                  70                  75                  80  


Gly Leu Ala Glu Ala Gly Arg Gly Arg Glu Asp Val Arg Thr Glu Leu 
                85                  90                  95      


Phe Arg Ala Leu Glu Ala Val Arg Leu Gln Asn Asn Ser Cys Glu Pro 
            100                 105                 110         


Cys Pro Thr Ser Trp Leu Ser Phe Glu Gly Ser Cys Tyr Phe Phe Ser 
        115                 120                 125             


Val Pro Lys Thr Thr Trp Ala Ala Ala Gln Asp His Cys Ala Asp Ala 
    130                 135                 140                 


Ser Ala His Leu Val Ile Val Gly Gly Leu Asp Glu Gln Gly Phe Leu 
145                 150                 155                 160 


Thr Arg Asn Thr Arg Gly Arg Gly Tyr Trp Leu Gly Leu Arg Ala Val 
                165                 170                 175     


Arg His Leu Gly Lys Val Gln Gly Tyr Gln Trp Val Asp Gly Val Ser 
            180                 185                 190         


Leu Ser Phe Ser His Trp Asn Gln Gly Glu Pro Asn Asp Ala Trp Gly 
        195                 200                 205             


Arg Glu Asn Cys Val Met Met Leu His Thr Gly Leu Trp Asn Asp Ala 
    210                 215                 220                 


Pro Cys Asp Ser Glu Lys Asp Gly Trp Ile Cys Glu Lys Arg His Asn 
225                 230                 235                 240 


Cys 
    


<210>  108
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210>  109
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala 
            20          


<210>  110
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  111
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala 
            20                  25              


<210>  112
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  112

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         


Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             


Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 


Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 


Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     


His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         


Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             


Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 


Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 


Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     


Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             


Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 


Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         


Thr Phe Pro Pro Glu Ala 
        435             


<210>  113
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  113

Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val 
1               5                   10                  15      


Ala Leu Ala Phe Val 
            20      


<210>  114
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  115
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala 
            20                  


<210>  116
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  116

Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
1               5                   10                  15      


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
            20                  25                  30          


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
        35                  40                  45              


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
    50                  55                  60                  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
65                  70                  75                  80  


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
                85                  90                  95      


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
            100                 105                 110         


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
        115                 120                 125             


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
    130                 135                 140                 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
145                 150                 155                 160 


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
                165                 170                 175     


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
            180                 185                 190         


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
        195                 200                 205             


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
    210                 215                 220                 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230                 235 


<210>  117
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  117

Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu 
1               5                   10                  15      


Ser Pro Tyr Leu Met 
            20      


<210>  118
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 endodomain

<400>  118

Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr Asp Pro 
1               5                   10                  15      


Thr Arg Arg Phe Phe Lys Val Thr Pro Pro Pro Gly Ser Gly Pro Gln 
            20                  25                  30          


Asn Gln Tyr Gly Asn Val Leu Ser Leu Pro Thr Pro Thr Ser Gly Leu 
        35                  40                  45              


Gly Arg Ala Gln Arg Trp Ala Ala Gly Leu Gly Gly Thr Ala Pro Ser 
    50                  55                  60                  


Tyr Gly Asn Pro Ser Ser Asp Val Gln Ala Asp Gly Ala Leu Gly Ser 
65                  70                  75                  80  


Arg Ser Pro Pro Gly Val Gly Pro Glu Glu Glu Glu Gly Glu Gly Tyr 
                85                  90                  95      


Glu Glu Pro Asp Ser Glu Glu Asp Ser Glu Phe Tyr Glu Asn Asp Ser 
            100                 105                 110         


Asn Leu Gly Gln Asp Gln Leu Ser Gln Asp Gly Ser Gly Tyr Glu Asn 
        115                 120                 125             


Pro Glu Asp Glu Pro Leu Gly Pro Glu Asp Glu Asp Ser Phe Ser Asn 
    130                 135                 140                 


Ala Glu Ser Tyr Glu Asn Glu Asp Glu Glu Leu Thr Gln Pro Val Ala 
145                 150                 155                 160 


Arg Thr Met Asp Phe Leu Ser Pro His Gly Ser Ala Trp Asp Pro Ser 
                165                 170                 175     


Arg Glu Ala Thr Ser Leu Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly 
            180                 185                 190         


Ile Leu Tyr Ala Ala Pro Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly 
        195                 200                 205             


Pro Asn His Glu Glu Asp Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro 
    210                 215                 220                 


Asp Gly Pro Asp Pro Ala Trp Gly Gly Gly Gly Arg Met Gly Thr Trp 
225                 230                 235                 240 


Ser Thr Arg 
            


<210>  119
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated CD19 endodomain

<400>  119

Gln Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr Asp Pro 
1               5                   10                  15      


Thr Arg Arg 
            


<210>  120
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 endodomain

<400>  120

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  121
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS endodomain

<400>  121

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  122
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4 endodomain

<400>  122

Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr 
1               5                   10                  15      


Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu Lys Gln 
            20                  25                  30          


Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
        35                  40      


<210>  123
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB endodomain

<400>  123

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  124
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 endodomain

<400>  124

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD30 endodomain

<400>  125

Cys His Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu 
1               5                   10                  15      


Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser 
            20                  25                  30          


Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr 
        35                  40                  45              


Glu Pro Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu 
    50                  55                  60                  


Thr Cys His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln 
65                  70                  75                  80  


Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu 
                85                  90                  95      


Pro Arg Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr 
            100                 105                 110         


Ile Met Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu 
        115                 120                 125             


Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu 
    130                 135                 140                 


Glu Leu Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu 
145                 150                 155                 160 


Pro Pro Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu 
                165                 170                 175     


Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185                 


<210>  126
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX-40 endodomain

<400>  126

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  127
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI endodomain

<400>  127

Lys Lys Arg Gly Asp Pro Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg 
1               5                   10                  15      


Gln Ser Pro Ala Lys Ser Ser Gln Asp His Ala Met Glu Ala Gly Ser 
            20                  25                  30          


Pro Val Ser Thr Ser Pro Glu Pro Val Glu Thr Cys Ser Phe Cys Phe 
        35                  40                  45              


Pro Glu Cys Arg Ala Pro Thr Gln Glu Ser Ala Val Thr Pro Gly Thr 
    50                  55                  60                  


Pro Asp Pro Thr Cys Ala Gly Arg Trp Gly Cys His Thr Arg Thr Thr 
65                  70                  75                  80  


Val Leu Gln Pro Cys Pro His Ile Pro Asp Ser Gly Leu Gly Ile Val 
                85                  90                  95      


Cys Val Pro Ala Gln Glu Gly Gly Pro Gly Ala 
            100                 105         


<210>  128
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GITR endodmain

<400>  128

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  129
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 endodomain

<400>  129

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser 
        115 


<210>  130
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40 endodomain

<400>  130

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  131
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant calcineurin B, CnB30

<400>  131

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Thr Lys Leu Ala Asp 
        115                 120                 125             


Thr Gln Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys 
    130                 135                 140                 


Asp Gly Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly 
145                 150                 155                 160 


Gly Leu Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170         


<210>  132
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  132

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  133
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM (immunoreceptor tyrosine-based activation motif)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Leu or Ile

<400>  133

Tyr Xaa Xaa Xaa 
1               


