                         SEQUENCE LISTING

<110>  King's College London
       Northwestern University
 
<120>  ChiA Enzyme

<130>  PN836686WO

<150>  US 63/005592
<151>  2020-04-06

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD crystal structure amino acid sequence

<400>  1

Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys Thr Pro Pro Ala Ala 
1               5                   10                  15      


Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val Met Ile Ala Phe Gly 
            20                  25                  30          


Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val Pro Ala Phe Glu Thr 
        35                  40                  45              


Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln Ala Gly Ile Lys Val 
    50                  55                  60                  


Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile Pro Asn Thr Thr Val 
65                  70                  75                  80  


Asp Phe His Gln Val Leu Val Ala Ser Ser Ser Pro Glu Ala Phe Lys 
                85                  90                  95      


Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile Ser Gln Tyr Gly Phe 
            100                 105                 110         


Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile Asn Ala Ser Gly Ser 
        115                 120                 125             


Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu Ala Ser Ile Ile Asn 
    130                 135                 140                 


Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile Thr Leu Thr Pro Gln 
145                 150                 155                 160 


Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp Gln Thr Trp Gly Asn 
                165                 170                 175     


Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser Leu Ala Trp Val Gly 
            180                 185                 190         


Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly Ile Asp Gln Val Cys 
        195                 200                 205             


Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe Ser Val Ala Met Ala 
    210                 215                 220                 


Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val Asn Gly Arg Pro Thr 
225                 230                 235                 240 


Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro Ser Gln Ile Val Ile 
                245                 250                 255     


Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser Asp Gly Ser Pro Val 
            260                 265                 270         


Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln Cys Leu Lys Thr Ala 
        275                 280                 285             


Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val Pro Pro Arg Ala Tyr 
    290                 295                 300                 


Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val Thr Tyr Asp Lys Asn 
305                 310                 315                 320 


Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn Cys Ala Ile Asn Gly 
                325                 330                 335     


Val Cys Glu 
            


<210>  2
<211>  762
<212>  PRT
<213>  Legionella pneumophila

<400>  2

Asn Thr Ser Leu Lys Pro Ser Ile Ala Gln Pro Thr Ala Cys Val Asn 
1               5                   10                  15      


Ser Leu Phe Thr Ala Thr Gly Asn Gln His Trp Lys Ser Ile Val Leu 
            20                  25                  30          


Lys Leu Thr Asn Asn Cys Asn Gln Ala Val Asp Phe Gln Asn Ser Thr 
        35                  40                  45              


Val Ser Phe Gln Thr Thr Ala Ala Leu Asn Thr Ser Phe Trp Gly Asp 
    50                  55                  60                  


Phe Ser Pro Leu Ser Tyr Pro Asp Asn Ala Leu Asn Ile Ser Ser Gln 
65                  70                  75                  80  


Pro Gln Ser Gly Gly Asn Tyr Leu Ala Thr Leu Asn Leu His Phe Pro 
                85                  90                  95      


Ser Tyr Pro Gly Ala Asn Ser Lys Leu Pro Val Gly Ser Ser Ile Ser 
            100                 105                 110         


Ile Lys Tyr Gly Ala Val Thr Asp Ser His Ile Glu Gly Thr Ala Asn 
        115                 120                 125             


Val Tyr Leu Ser Thr Thr Val Glu Ser Gly Ser Ile Gln Leu Ile Asn 
    130                 135                 140                 


Ala Ala Ala Lys Pro Thr Asn Val Ser Gln Gly Tyr Ala Leu Val His 
145                 150                 155                 160 


Val Thr Met Asn Gly Gln Ser Val Ser Asp Val Gln Leu Pro Trp Glu 
                165                 170                 175     


Thr Ser Lys Thr Leu Ser Gly Phe Ala Ala Gly Asn Tyr Ala Ile Ser 
            180                 185                 190         


Ala Glu Thr Val Thr Asp Ser Asn Gly Asn Leu Tyr Leu Gly Gln Ala 
        195                 200                 205             


Asn Pro Ser Met Val Asn Val Ile Ala Asn Gln Thr Thr Ser Ser Thr 
    210                 215                 220                 


Ile Asn Tyr Ala Arg Val Gln Glu Thr Gly Lys Ile Lys Ile His Val 
225                 230                 235                 240 


Gln Asn Leu Pro Gly Glu Leu Ser Asn Tyr Asn Glu Asn Pro Thr Val 
                245                 250                 255     


Leu Ile Thr Gln Ser Gln Ser Gly Asn Ser Arg Ser Gln His Ala Val 
            260                 265                 270         


Trp Gly Asn Thr Thr Thr Val Ala Glu Leu Lys Glu Gly Ser Ser Tyr 
        275                 280                 285             


Gln Phe Ser Thr Pro Ala Ile Gln Tyr Asn Asp Tyr Asn Cys Trp Pro 
    290                 295                 300                 


Thr Phe Thr Pro Ser Ser Leu Val Ala Ser Ala Ala Asn Val Pro Thr 
305                 310                 315                 320 


Thr Asn Leu Thr Tyr Gln Cys Ala Gln Ile Val Lys Asp Asn Val Thr 
                325                 330                 335     


Ile Asn Val Ser Gly Ala Pro Ser Ser Leu Ala Ser Leu Lys Ile Ile 
            340                 345                 350         


Leu Thr Pro Asn Asp Gly Ser Gln Thr Val Glu Gln Thr Ile Asp Leu 
        355                 360                 365             


Ala Asn Gly Val Gly Ser Ser Ala Ile Ser Leu Thr Asp Gly Val Ile 
    370                 375                 380                 


Tyr Thr Leu Ser Ser Glu Gly Val Pro Gly Tyr Thr Val Gln Phe Ser 
385                 390                 395                 400 


Pro Gln Pro Leu Thr Ala Thr Glu Asn Ala Thr Val Asn Ile Thr Leu 
                405                 410                 415     


Ser Pro Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly 
            420                 425                 430         


Trp Lys Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr 
        435                 440                 445             


His Val Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val 
    450                 455                 460                 


Ile Val Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu 
465                 470                 475                 480 


His Gln Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr 
                485                 490                 495     


Ser Ile Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser 
            500                 505                 510         


Ser Ser Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu 
        515                 520                 525             


Leu Ile Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His 
    530                 535                 540                 


Gly Ile Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala 
545                 550                 555                 560 


Val Leu Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu 
                565                 570                 575     


Leu Ile Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly 
            580                 585                 590         


Phe Asp Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His 
        595                 600                 605             


Gln Ser Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala 
    610                 615                 620                 


Phe Gly Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro 
625                 630                 635                 640 


Asp Phe Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala 
                645                 650                 655     


Thr Val Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu 
            660                 665                 670         


Arg Pro Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly 
        675                 680                 685             


Gly Ser Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala 
    690                 695                 700                 


Ile Gln Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val 
705                 710                 715                 720 


Tyr Val Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp 
                725                 730                 735     


Glu Val Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu 
            740                 745                 750         


Lys Asn Cys Ala Ile Asn Gly Val Cys Glu 
        755                 760         


<210>  3
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD crystal structure nucleic acid sequence

<400>  3
gggcgtatta ttggttacgt accgggatgg aaaactccac ctgccgctca agagttggct       60

agcgcgggtt atactcatgt catgattgct ttcggcgtat ttagtaccaa tactccgggt      120

gttattgttc ctgcttttga aacaataacc aaagaatata ttcagtctct tcatcaagcc      180

gggattaaag ttattctttc tttaggtggt gcgttaacta gtattcccaa tacaacagta      240

gattttcacc aggttttagt agcttcttct tcaccagagg catttaaaca aacatttatc      300

aactctttaa aggagttaat ttctcaatat ggttttgatg ggtttgatac agatattgag      360

catggtatta acgctagcgg ttccttttct caaccacagg gtgacattgc tgtcttagca      420

agcattatca atacgatgta cagccaaaat tcttctctgc taattactct gacacctcaa      480

gtggctaata ttgctgcaac aagcggtttc gaccaaacct gggggaatta tgcctcttta      540

attatgcaaa cccatcagtc tttagcgtgg gtaggtatcc agctttacaa tacaggatgt      600

gctttcggaa ttgatcaagt atgctatggt cctacaccaa ctgatacccc tgatttttca      660

gtagctatgg ctaccgattt attggagaat tggccagcaa cggtcaatgg acgtcctaca      720

ggatttcaac cttatattag ctatttaaga ccttcccaaa ttgtcattgg ttatccatct      780

ccaaatgcta gtggtggcag tgacggttca ccggttactc cgacaaccac aatcaagcgg      840

gctattcagt gccttaagac agcaattgcc ggtaatacca gttgtggtgt ttatgttccg      900

ccaagagctt atgggaatat cggtggtgta tttaactggg aagtaactta tgataagaac      960

aatcaattca aatttgcaaa agaattgaaa aattgtgcta ttaatggtgt ttgtgagtaa     1020


<210>  4
<211>  2289
<212>  DNA
<213>  Legionella pneumophila

<400>  4
aatacctctt taaaaccctc aattgcccag cctacagcct gtgtaaactc actttttaca       60

gcaacgggaa atcaacactg gaaatcaatc gtattaaagt taaccaataa ttgcaatcag      120

gcagtcgatt ttcaaaattc aactgtctcc tttcaaacaa cagcagcttt aaatacctct      180

ttttgggggg atttttctcc tttatcttac ccggataatg ctttaaatat ttcttctcaa      240

cctcaatctg gcggaaacta tctagccact ttaaacctgc attttcccag ctatccgggt      300

gctaatagca agttacctgt cggaagttct atttcaatta aatatggggc agtcactgat      360

agtcatatcg agggaacggc taatgtttat ttaagcacaa cggttgaatc aggaagcatc      420

caattaatca atgctgctgc aaaaccaaca aatgtgtcac aaggatatgc attagttcat      480

gtcacaatga atggtcaatc agtcagtgat gtgcaattac catgggaaac ttcaaagact      540

ctatctgggt ttgctgcagg taattatgct atttctgctg aaacggttac tgacagtaat      600

ggcaatcttt atctgggaca ggccaatccc agcatggtga atgtgattgc aaaccaaaca      660

acgagctcga ctattaatta tgctcgggta caagagacag gcaagatcaa gatccatgtg      720

cagaacctcc ctggcgaatt aagcaactac aatgaaaatc caactgttct aattacccag      780

agtcaatcag gaaattcacg ctcacagcat gccgtttggg ggaacacaac gactgttgct      840

gagttgaaag aggggagtag ttaccaattc tcaactcctg caattcaata taacgattac      900

aattgctggc ccactttcac accatcttcc ttagtggcaa gtgctgcaaa tgttccaact      960

accaatttaa cctatcagtg tgcccagatt gtgaaagata atgtgacaat taatgtcagt     1020

ggcgctccat cctccctggc ttcattgaaa attattttaa ctcccaacga tggttcacaa     1080

acagtagaac agacaataga tttggccaat ggtgttggtt catctgccat ttctttaact     1140

gacggggtta tttatacact ttcaagtgaa ggtgttcccg gctatacagt acaattttcg     1200

ccccaacctt taacagcaac agaaaatgca acagtaaaca tcactttatc tccggtaacc     1260

gctgcaaaag ggcgtattat tggttacgta ccgggatgga aaactccacc tgccgctcaa     1320

gagttggcta gcgcgggtta tactcatgtc atgattgctt tcggcgtatt tagtaccaat     1380

actccgggtg ttattgttcc tgcttttgaa acaataacca aagaatatat tcagtctctt     1440

catcaagccg ggattaaagt tattctttct ttaggtggtg cgttaactag tattcccaat     1500

acaacagtag attttcacca ggttttagta gcttcttctt caccagaggc atttaaacaa     1560

acatttatca actctttaaa ggagttaatt tctcaatatg gttttgatgg gtttgataca     1620

gatattgagc atggtattaa cgctagcggt tccttttctc aaccacaggg tgacattgct     1680

gtcttagcaa gcattatcaa tacgatgtac agccaaaatt cttctctgct aattactctg     1740

acacctcaag tggctaatat tgctgcaaca agcggtttcg accaaacctg ggggaattat     1800

gcctctttaa ttatgcaaac ccatcagtct ttagcgtggg taggtatcca gctttacaat     1860

acaggatgtg ctttcggaat tgatcaagta tgctatggtc ctacaccaac tgatacccct     1920

gatttttcag tagctatggc taccgattta ttggagaatt ggccagcaac ggtcaatgga     1980

cgtcctacag gatttcaacc ttatattagc tatttaagac cttcccaaat tgtcattggt     2040

tatccatctc caaatgctag tggtggcagt gacggttcac cggttactcc gacaaccaca     2100

atcaagcggg ctattcagtg ccttaagaca gcaattgccg gtaataccag ttgtggtgtt     2160

tatgttccgc caagagctta tgggaatatc ggtggtgtat ttaactggga agtaacttat     2220

gataagaaca atcaattcaa atttgcaaaa gaattgaaaa attgtgctat taatggtgtt     2280

tgtgagtaa                                                             2289


<210>  5
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chiA NTD-domain amino acid sequence

<400>  5

Asn Thr Ser Leu Lys Pro Ser Ile Ala Gln Pro Thr Ala Cys Val Asn 
1               5                   10                  15      


Ser Leu Phe Thr Ala Thr Gly Asn Gln His Trp Lys Ser Ile Val Leu 
            20                  25                  30          


Lys Leu Thr Asn Asn Cys Asn Gln Ala Val Asp Phe Gln Asn Ser Thr 
        35                  40                  45              


Val Ser Phe Gln Thr Thr Ala Ala Leu Asn Thr Ser Phe Trp Gly Asp 
    50                  55                  60                  


Phe Ser Pro Leu Ser Tyr Pro Asp Asn Ala Leu Asn Ile Ser Ser Gln 
65                  70                  75                  80  


Pro Gln Ser Gly Gly Asn Tyr Leu Ala Thr Leu Asn Leu His Phe Pro 
                85                  90                  95      


Ser Tyr Pro Gly Ala Asn Ser Lys Leu Pro Val Gly Ser Ser Ile Ser 
            100                 105                 110         


Ile Lys Tyr Gly Ala Val Thr Asp Ser His Ile Glu Gly Thr Ala Asn 
        115                 120                 125             


Val Tyr Leu Ser Thr Thr Val Glu Ser Gly Ser Ile Gln Leu Ile Asn 
    130                 135                 140                 


Ala Ala Ala Lys Pro Thr Asn Val Ser Gln Gly Tyr Ala Leu Val His 
145                 150                 155                 160 


Val Thr Met Asn Gly Gln Ser Val Ser Asp Val Gln Leu Pro Trp Glu 
                165                 170                 175     


Thr Ser Lys Thr Leu Ser Gly Phe Ala Ala Gly Asn Tyr Ala Ile Ser 
            180                 185                 190         


Ala Glu Thr Val Thr Asp Ser Asn Gly Asn Leu Tyr Leu Gly Gln Ala 
        195                 200                 205             


Asn Pro Ser Met Val Asn Val Ile Ala Asn Gln Thr Thr Ser Ser Thr 
    210                 215                 220                 


Ile Asn Tyr Ala Arg Val Gln Glu Thr Gly Lys Ile Lys Ile His Val 
225                 230                 235                 240 


Gln Asn Leu Pro Gly Glu Leu Ser Asn Tyr Asn Glu Asn Pro Thr Val 
                245                 250                 255     


Leu Ile Thr Gln Ser Gln Ser Gly Asn Ser Arg Ser Gln His Ala Val 
            260                 265                 270         


Trp Gly Asn Thr Thr Thr Val Ala Glu Leu Lys Glu Gly Ser Ser Tyr 
        275                 280                 285             


Gln Phe Ser Thr Pro Ala Ile Gln Tyr Asn Asp Tyr Asn Cys Trp Pro 
    290                 295                 300                 


Thr Phe Thr Pro Ser Ser Leu Val Ala Ser Ala Ala Asn Val Pro Thr 
305                 310                 315                 320 


Thr Asn Leu Thr Tyr Gln Cys Ala Gln Ile Val Lys Asp Asn Val Thr 
                325                 330                 335     


Ile Asn Val Ser Gly Ala Pro Ser Ser Leu Ala Ser Leu Lys Ile Ile 
            340                 345                 350         


Leu Thr Pro Asn Asp Gly Ser Gln Thr Val Glu Gln Thr Ile Asp Leu 
        355                 360                 365             


Ala Asn Gly Val Gly Ser Ser Ala Ile Ser Leu Thr Asp Gly Val Ile 
    370                 375                 380                 


Tyr Thr Leu Ser Ser Glu Gly Val Pro Gly Tyr Thr Val Gln Phe Ser 
385                 390                 395                 400 


Pro Gln Pro Leu Thr Ala Thr Glu Asn Ala Thr Val Asn Ile Thr Leu 
                405                 410                 415     


Ser 
    


<210>  6
<211>  668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chiA NTD-domain nucleic acid sequence

<400>  6
cggttactga cagtaatggc aatctttatc tgggacaggc caatcccagc atggtgaatg       60

tgattgcaaa ccaaacaacg agctcgacta ttaattatgc tcgggtacaa gagacaggca      120

agatcaagat ccatgtgcag aacctccctg gcgaattaag caactacaat gaaaatccaa      180

ctgttctaat tacccagagt caatcaggaa attcacgctc acagcatgcc gtttggggga      240

acacaacgac tgttgctgag ttgaaagagg ggagtagtta ccaattctca actcctgcaa      300

ttcaatataa cgattacaat tgctggccca ctttcacacc atcttcctta gtggcaagtg      360

ctgcaaatgt tccaactacc aatttaacct atcagtgtgc ccagattgtg aaagataatg      420

tgacaattaa tgtcagtggc gctccatcct ccctggcttc attgaaaatt attttaactc      480

ccaacgatgg ttcacaaaca gtagaacaga caatagattt ggccaatggt gttggttcat      540

ctgccatttc tttaactgac ggggttattt atacactttc aagtgaaggt gttcccggct      600

atacagtaca attttcgccc caacctttaa cagcaacaga aaatgcaaca gtaaacatca      660

ctttatct                                                               668


<210>  7
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chiA N1-domain amino acid sequence

<400>  7

Asn Thr Ser Leu Lys Pro Ser Ile Ala Gln Pro Thr Ala Cys Val Asn 
1               5                   10                  15      


Ser Leu Phe Thr Ala Thr Gly Asn Gln His Trp Lys Ser Ile Val Leu 
            20                  25                  30          


Lys Leu Thr Asn Asn Cys Asn Gln Ala Val Asp Phe Gln Asn Ser Thr 
        35                  40                  45              


Val Ser Phe Gln Thr Thr Ala Ala Leu Asn Thr Ser Phe Trp Gly Asp 
    50                  55                  60                  


Phe Ser Pro Leu Ser Tyr Pro Asp Asn Ala Leu Asn Ile Ser Ser Gln 
65                  70                  75                  80  


Pro Gln Ser Gly Gly Asn Tyr Leu Ala Thr Leu Asn Leu His Phe Pro 
                85                  90                  95      


Ser Tyr Pro Gly Ala Asn Ser Lys Leu Pro Val Gly Ser Ser Ile Ser 
            100                 105                 110         


Ile Lys Tyr Gly Ala Val Thr Asp Ser His Ile Glu Gly Thr Ala Asn 
        115                 120                 125             


Val Tyr Leu Ser Thr Thr Val Glu Ser Gly Ser Ile 
    130                 135                 140 


<210>  8
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chiA N1-domain nucleic acid sequence

<400>  8
aatacctctt taaaaccctc aattgcccag cctacagcct gtgtaaactc actttttaca       60

gcaacgggaa atcaacactg gaaatcaatc gtattaaagt taaccaataa ttgcaatcag      120

gcagtcgatt ttcaaaattc aactgtctcc tttcaaacaa cagcagcttt aaatacctct      180

ttttgggggg atttttctcc tttatcttac ccggataatg ctttaaatat ttcttctcaa      240

cctcaatctg gcggaaacta tctagccact ttaaacctgc attttcccag ctatccgggt      300

gctaatagca agttacctgt cggaagttct atttcaatta aatatggggc agtcactgat      360

agtcatatcg agggaacggc taatgtttat ttaagcacaa cggttgaatc aggaagcatc      420


<210>  9
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chiA N2-domain amino acid sequence

<400>  9

Gln Leu Ile Asn Ala Ala Ala Lys Pro Thr Asn Val Ser Gln Gly Tyr 
1               5                   10                  15      


Ala Leu Val His Val Thr Met Asn Gly Gln Ser Val Ser Asp Val Gln 
            20                  25                  30          


Leu Pro Trp Glu Thr Ser Lys Thr Leu Ser Gly Phe Ala Ala Gly Asn 
        35                  40                  45              


Tyr Ala Ile Ser Ala Glu Thr Val Thr Asp Ser Asn Gly Asn Leu Tyr 
    50                  55                  60                  


Leu Gly Gln Ala Asn Pro Ser Met Val Asn Val Ile Ala Asn Gln Thr 
65                  70                  75                  80  


Thr Ser Ser Thr Ile Asn Tyr Ala Arg Val Gln Glu Thr Gly Lys Ile 
                85                  90                  95      


Lys Ile His Val Gln Asn Leu Pro Gly Glu Leu Ser Asn Tyr Asn Glu 
            100                 105                 110         


Asn Pro Thr Val Leu Ile Thr Gln Ser Gln Ser Gly Asn Ser Arg Ser 
        115                 120                 125             


Gln His Ala Val Trp Gly Asn Thr Thr Thr Val Ala Glu Leu Lys Glu 
    130                 135                 140                 


<210>  10
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chiA N2-domain nucleic acid sequence

<400>  10
caattaatca atgctgctgc aaaaccaaca aatgtgtcac aaggatatgc attagttcat       60

gtcacaatga atggtcaatc agtcagtgat gtgcaattac catgggaaac ttcaaagact      120

ctatctgggt ttgctgcagg taattatgct atttctgctg aaacggttac tgacagtaat      180

ggcaatcttt atctgggaca ggccaatccc agcatggtga atgtgattgc aaaccaaaca      240

acgagctcga ctattaatta tgctcgggta caagagacag gcaagatcaa gatccatgtg      300

cagaacctcc ctggcgaatt aagcaactac aatgaaaatc caactgttct aattacccag      360

agtcaatcag gaaattcacg ctcacagcat gccgtttggg ggaacacaac gactgttgct      420

gagttgaaag ag                                                          432


<210>  11
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chiA N3-domain amino acid sequence

<400>  11

Gly Ser Ser Tyr Gln Phe Ser Thr Pro Ala Ile Gln Tyr Asn Asp Tyr 
1               5                   10                  15      


Asn Cys Trp Pro Thr Phe Thr Pro Ser Ser Leu Val Ala Ser Ala Ala 
            20                  25                  30          


Asn Val Pro Thr Thr Asn Leu Thr Tyr Gln Cys Ala Gln Ile Val Lys 
        35                  40                  45              


Asp Asn Val Thr Ile Asn Val Ser Gly Ala Pro Ser Ser Leu Ala Ser 
    50                  55                  60                  


Leu Lys Ile Ile Leu Thr Pro Asn Asp Gly Ser Gln Thr Val Glu Gln 
65                  70                  75                  80  


Thr Ile Asp Leu Ala Asn Gly Val Gly Ser Ser Ala Ile Ser Leu Thr 
                85                  90                  95      


Asp Gly Val Ile Tyr Thr Leu Ser Ser Glu Gly Val Pro Gly Tyr Thr 
            100                 105                 110         


Val Gln Phe Ser Pro Gln Pro Leu Thr Ala Thr Glu Asn Ala Thr Val 
        115                 120                 125             


Asn Ile Thr Leu Ser 
    130             


<210>  12
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chiA N3-domain nucleic acid sequence

<400>  12
gggagtagtt accaattctc aactcctgca attcaatata acgattacaa ttgctggccc       60

actttcacac catcttcctt agtggcaagt gctgcaaatg ttccaactac caatttaacc      120

tatcagtgtg cccagattgt gaaagataat gtgacaatta atgtcagtgg cgctccatcc      180

tccctggctt cattgaaaat tattttaact cccaacgatg gttcacaaac agtagaacag      240

acaatagatt tggccaatgg tgttggttca tctgccattt ctttaactga cggggttatt      300

tatacacttt caagtgaagg tgttcccggc tatacagtac aattttcgcc ccaaccttta      360

acagcaacag aaaatgcaac agtaaacatc actttatct                             399


<210>  13
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD D504A mutant amino acid sequence

<400>  13

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Ala Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  14
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD D504A mutant nucleic acid sequence

<400>  14
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgcgtt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgagcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  15
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD H506A mutant amino acid sequence

<400>  15

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe Ala Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  16
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD H506A mutant nucleic acid sequence

<400>  16
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tgcgcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgagcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  17
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M mutant amino acid sequence

<400>  17

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Met His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  18
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M mutant nucleic acid sequence

<400>  18
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttatgcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  19
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD H544A mutant amino acid sequence

<400>  19

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu Ala Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  20
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD H544A mutant nucleic acid sequence

<400>  20
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgaggcggg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  21
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD N547A mutant amino acid sequence

<400>  21

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Ala Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  22
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD N547A mutant nucleic acid sequence

<400>  22
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgagcatgg tattgcggcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  23
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD Q595A mutant amino acid sequence

<400>  23

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Ala Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  24
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD Q595A mutant nucleic acid sequence

<400>  24
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgagcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatgc gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  25
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD Q583A mutant amino acid sequence

<400>  25

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Ala Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  26
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD Q583A mutant nucleic acid sequence

<400>  26
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgagcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cggcggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  27
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD Q617A mutant amino acid sequence

<400>  27

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Ala Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  28
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD Q617A mutant nucleic acid sequence

<400>  28
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttgagcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattgcgctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  29
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/D504A mutant amino acid sequence

<400>  29

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Ala Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Met His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  30
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/D504A mutant nucleic acid sequence

<400>  30
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgcgtt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttatgcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  31
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/H506A mutant amino acid sequence

<400>  31

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe Ala Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Met His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  32
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/H506A mutant nucleic acid sequence

<400>  32
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tgcgcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttatgcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  33
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/H544A mutant amino acid sequence

<400>  33

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Met Ala Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  34
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/H544A mutant nucleic acid sequence

<400>  34
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttatggcggg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  35
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/N547A mutant amino acid sequence

<400>  35

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Met His Gly Ile 
        115                 120                 125             


Ala Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  36
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/N547A mutant nucleic acid sequence

<400>  36
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttatgcatgg tattgcggcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatca gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  37
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/Q595A mutant amino acid sequence

<400>  37

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Met His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Ala Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  38
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD E543M/Q595A mutant nucleic acid sequence

<400>  38
gttaccgcag caaaaggtcg cattattggt tatgttccag gttggaaaac ccctccggca       60

gcacaagaac tggcaagcgc aggttatacc catgttatga ttgcatttgg tgtgttcagc      120

accaatacac cgggtgttat tgttccggca tttgaaacca ttaccaaaga gtatattcag      180

agcctgcatc aggcaggcat taaagttatt ctgagcttag gtggtgcact gaccagcatt      240

ccgaatacca ccgttgattt tcatcaggtt ctggttgcaa gcagcagtcc ggaagcattt      300

aaacagacct ttattaacag cctgaaagaa ctgattagcc agtatggttt tgatggcttt      360

gataccgata ttatgcatgg tattaatgcc agcggtagct ttagccagcc gcagggtgat      420

attgcagttc tggcaagcat tattaacacc atgtatagcc agaatagcag cctgctgatt      480

accctgacac cgcaggttgc aaatattgca gcaaccagcg gttttgatgc gacctggggt      540

aattatgcaa gcctgattat gcagacccat cagagtctgg catgggttgg tattcagctg      600

tataataccg gttgtgcctt tggtattgat caggtttgtt atggtccgac accgaccgat      660

acaccggatt ttagcgttgc aatggcaacc gatctgctgg aaaattggcc tgcaaccgtt      720

aatggtcgtc cgaccggttt tcagccgtat attagctatc tgcgtccgag ccagattgtg      780

attggttatc cgagtccgaa tgcaagcggt ggtagtgatg gtagtccggt tacaccgacc      840

accaccatta aacgtgcaat tcagtgtctg aaaacagcca ttgcaggtaa taccagctgt      900

ggtgtttatg ttccgcctcg tgcatatggt aatattggtg gtgtgtttaa ttgggaagtg      960

acctacgata aaaacaacca gttcaaattc gccaaagagc tgaaaaattg cgcgattaat     1020

ggcgtgtgtg aa                                                         1032


<210>  39
<211>  5654
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Val Gly Arg Arg Lys Leu Ala Leu Leu Trp Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Ala Cys Thr Arg His Thr Gly His Ala Gln Asp Gly Ser Ser 
            20                  25                  30          


Glu Ser Ser Tyr Lys His His Pro Ala Leu Ser Pro Ile Ala Arg Gly 
        35                  40                  45              


Pro Ser Gly Val Pro Leu Arg Gly Ala Thr Val Phe Pro Ser Leu Arg 
    50                  55                  60                  


Thr Ile Pro Val Val Arg Ala Ser Asn Pro Ala His Asn Gly Arg Val 
65                  70                  75                  80  


Cys Ser Thr Trp Gly Ser Phe His Tyr Lys Thr Phe Asp Gly Asp Val 
                85                  90                  95      


Phe Arg Phe Pro Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Gly 
            100                 105                 110         


Ala Ala Tyr Glu Asp Phe Asn Ile Gln Leu Arg Arg Ser Gln Glu Ser 
        115                 120                 125             


Ala Ala Pro Thr Leu Ser Arg Val Leu Met Lys Val Asp Gly Val Val 
    130                 135                 140                 


Ile Gln Leu Thr Lys Gly Ser Val Leu Val Asn Gly His Pro Val Leu 
145                 150                 155                 160 


Leu Pro Phe Ser Gln Ser Gly Val Leu Ile Gln Gln Ser Ser Ser Tyr 
                165                 170                 175     


Thr Lys Val Glu Ala Arg Leu Gly Leu Val Leu Met Trp Asn His Asp 
            180                 185                 190         


Asp Ser Leu Leu Leu Glu Leu Asp Thr Lys Tyr Ala Asn Lys Thr Cys 
        195                 200                 205             


Gly Leu Cys Gly Asp Phe Asn Gly Met Pro Val Val Ser Glu Leu Leu 
    210                 215                 220                 


Ser His Asn Thr Lys Leu Thr Pro Met Glu Phe Gly Asn Leu Gln Lys 
225                 230                 235                 240 


Met Asp Asp Pro Thr Asp Gln Cys Gln Asp Pro Val Pro Glu Pro Pro 
                245                 250                 255     


Arg Asn Cys Ser Thr Gly Phe Gly Ile Cys Glu Glu Leu Leu His Gly 
            260                 265                 270         


Gln Leu Phe Ser Gly Cys Val Ala Leu Val Asp Val Gly Ser Tyr Leu 
        275                 280                 285             


Glu Ala Cys Arg Gln Asp Leu Cys Phe Cys Glu Asp Thr Asp Leu Leu 
    290                 295                 300                 


Ser Cys Val Cys His Thr Leu Ala Glu Tyr Ser Arg Gln Cys Thr His 
305                 310                 315                 320 


Ala Gly Gly Leu Pro Gln Asp Trp Arg Gly Pro Asp Phe Cys Pro Gln 
                325                 330                 335     


Lys Cys Pro Asn Asn Met Gln Tyr His Glu Cys Arg Ser Pro Cys Ala 
            340                 345                 350         


Asp Thr Cys Ser Asn Gln Glu His Ser Arg Ala Cys Glu Asp His Cys 
        355                 360                 365             


Val Ala Gly Cys Phe Cys Pro Glu Gly Thr Val Leu Asp Asp Ile Gly 
    370                 375                 380                 


Gln Thr Gly Cys Val Pro Val Ser Lys Cys Ala Cys Val Tyr Asn Gly 
385                 390                 395                 400 


Ala Ala Tyr Ala Pro Gly Ala Thr Tyr Ser Thr Asp Cys Thr Asn Cys 
                405                 410                 415     


Thr Cys Ser Gly Gly Arg Trp Ser Cys Gln Glu Val Pro Cys Pro Gly 
            420                 425                 430         


Thr Cys Ser Val Leu Gly Gly Ala His Phe Ser Thr Phe Asp Gly Lys 
        435                 440                 445             


Gln Tyr Thr Val His Gly Asp Cys Ser Tyr Val Leu Thr Lys Pro Cys 
    450                 455                 460                 


Asp Ser Ser Ala Phe Thr Val Leu Ala Glu Leu Arg Arg Cys Gly Leu 
465                 470                 475                 480 


Thr Asp Ser Glu Thr Cys Leu Lys Ser Val Thr Leu Ser Leu Asp Gly 
                485                 490                 495     


Ala Gln Thr Val Val Val Ile Lys Ala Ser Gly Glu Val Phe Leu Asn 
            500                 505                 510         


Gln Ile Tyr Thr Gln Leu Pro Ile Ser Ala Ala Asn Val Thr Ile Phe 
        515                 520                 525             


Arg Pro Ser Thr Phe Phe Ile Ile Ala Gln Thr Ser Leu Gly Leu Gln 
    530                 535                 540                 


Leu Asn Leu Gln Leu Val Pro Thr Met Gln Leu Phe Met Gln Leu Ala 
545                 550                 555                 560 


Pro Lys Leu Arg Gly Gln Thr Cys Gly Leu Cys Gly Asn Phe Asn Ser 
                565                 570                 575     


Ile Gln Ala Asp Asp Phe Arg Thr Leu Ser Gly Val Val Glu Ala Thr 
            580                 585                 590         


Ala Ala Ala Phe Phe Asn Thr Phe Lys Thr Gln Ala Ala Cys Pro Asn 
        595                 600                 605             


Ile Arg Asn Ser Phe Glu Asp Pro Cys Ser Leu Ser Val Glu Asn Glu 
    610                 615                 620                 


Lys Tyr Ala Gln His Trp Cys Ser Gln Leu Thr Asp Ala Asp Gly Pro 
625                 630                 635                 640 


Phe Gly Arg Cys His Ala Ala Val Lys Pro Gly Thr Tyr Tyr Ser Asn 
                645                 650                 655     


Cys Met Phe Asp Thr Cys Asn Cys Glu Arg Ser Glu Asp Cys Leu Cys 
            660                 665                 670         


Ala Ala Leu Ser Ser Tyr Val His Ala Cys Ala Ala Lys Gly Val Gln 
        675                 680                 685             


Leu Gly Gly Trp Arg Asp Gly Val Cys Thr Lys Pro Met Thr Thr Cys 
    690                 695                 700                 


Pro Lys Ser Met Thr Tyr His Tyr His Val Ser Thr Cys Gln Pro Thr 
705                 710                 715                 720 


Cys Arg Ser Leu Ser Glu Gly Asp Ile Thr Cys Ser Val Gly Phe Ile 
                725                 730                 735     


Pro Val Asp Gly Cys Ile Cys Pro Lys Gly Thr Phe Leu Asp Asp Thr 
            740                 745                 750         


Gly Lys Cys Val Gln Ala Ser Asn Cys Pro Cys Tyr His Arg Gly Ser 
        755                 760                 765             


Met Ile Pro Asn Gly Glu Ser Val His Asp Ser Gly Ala Ile Cys Thr 
    770                 775                 780                 


Cys Thr His Gly Lys Leu Ser Cys Ile Gly Gly Gln Ala Pro Ala Pro 
785                 790                 795                 800 


Val Cys Ala Ala Pro Met Val Phe Phe Asp Cys Arg Asn Ala Thr Pro 
                805                 810                 815     


Gly Asp Thr Gly Ala Gly Cys Gln Lys Ser Cys His Thr Leu Asp Met 
            820                 825                 830         


Thr Cys Tyr Ser Pro Gln Cys Val Pro Gly Cys Val Cys Pro Asp Gly 
        835                 840                 845             


Leu Val Ala Asp Gly Glu Gly Gly Cys Ile Thr Ala Glu Asp Cys Pro 
    850                 855                 860                 


Cys Val His Asn Glu Ala Ser Tyr Arg Ala Gly Gln Thr Ile Arg Val 
865                 870                 875                 880 


Gly Cys Asn Thr Cys Thr Cys Asp Ser Arg Met Trp Arg Cys Thr Asp 
                885                 890                 895     


Asp Pro Cys Leu Ala Thr Cys Ala Val Tyr Gly Asp Gly His Tyr Leu 
            900                 905                 910         


Thr Phe Asp Gly Gln Ser Tyr Ser Phe Asn Gly Asp Cys Glu Tyr Thr 
        915                 920                 925             


Leu Val Gln Asn His Cys Gly Gly Lys Asp Ser Thr Gln Asp Ser Phe 
    930                 935                 940                 


Arg Val Val Thr Glu Asn Val Pro Cys Gly Thr Thr Gly Thr Thr Cys 
945                 950                 955                 960 


Ser Lys Ala Ile Lys Ile Phe Leu Gly Gly Phe Glu Leu Lys Leu Ser 
                965                 970                 975     


His Gly Lys Val Glu Val Ile Gly Thr Asp Glu Ser Gln Glu Val Pro 
            980                 985                 990         


Tyr Thr Ile Arg Gln Met Gly Ile  Tyr Leu Val Val Asp  Thr Asp Ile 
        995                 1000                 1005             


Gly Leu  Val Leu Leu Trp Asp  Lys Lys Thr Ser Ile  Phe Ile Asn 
    1010                 1015                 1020             


Leu Ser  Pro Glu Phe Lys Gly  Arg Val Cys Gly Leu  Cys Gly Asn 
    1025                 1030                 1035             


Phe Asp  Asp Ile Ala Val Asn  Asp Phe Ala Thr Arg  Ser Arg Ser 
    1040                 1045                 1050             


Val Val  Gly Asp Val Leu Glu  Phe Gly Asn Ser Trp  Lys Leu Ser 
    1055                 1060                 1065             


Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys Asp Pro  Cys Thr Ala 
    1070                 1075                 1080             


Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys Gln Cys  Ser Ile Leu 
    1085                 1090                 1095             


His Gly  Pro Thr Phe Ala Ala  Cys His Ala His Val  Glu Pro Ala 
    1100                 1105                 1110             


Arg Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala Cys Ala  Cys Asp Ser 
    1115                 1120                 1125             


Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala Val Ala  Ala Tyr Ala 
    1130                 1135                 1140             


Gln Ala  Cys His Glu Val Gly  Leu Cys Val Ser Trp  Arg Thr Pro 
    1145                 1150                 1155             


Ser Ile  Cys Pro Leu Phe Cys  Asp Tyr Tyr Asn Pro  Glu Gly Gln 
    1160                 1165                 1170             


Cys Glu  Trp His Tyr Gln Pro  Cys Gly Val Pro Cys  Leu Arg Thr 
    1175                 1180                 1185             


Cys Arg  Asn Pro Arg Gly Asp  Cys Leu Arg Asp Val  Arg Gly Leu 
    1190                 1195                 1200             


Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Glu Ala Pro  Ile Phe Asp 
    1205                 1210                 1215             


Glu Asp  Lys Met Gln Cys Val  Ala Thr Cys Pro Thr  Pro Pro Leu 
    1220                 1225                 1230             


Pro Pro  Arg Cys His Val His  Gly Lys Ser Tyr Arg  Pro Gly Ala 
    1235                 1240                 1245             


Val Val  Pro Ser Asp Lys Asn  Cys Gln Ser Cys Leu  Cys Thr Glu 
    1250                 1255                 1260             


Arg Gly  Val Glu Cys Thr Tyr  Lys Ala Glu Ala Cys  Val Cys Thr 
    1265                 1270                 1275             


Tyr Asn  Gly Gln Arg Phe His  Pro Gly Asp Val Ile  Tyr His Thr 
    1280                 1285                 1290             


Thr Asp  Gly Thr Gly Gly Cys  Ile Ser Ala Arg Cys  Gly Ala Asn 
    1295                 1300                 1305             


Gly Thr  Ile Glu Arg Arg Val  Tyr Pro Cys Ser Pro  Thr Thr Pro 
    1310                 1315                 1320             


Val Pro  Pro Thr Thr Phe Ser  Phe Ser Thr Pro Pro  Leu Val Val 
    1325                 1330                 1335             


Ser Ser  Thr His Thr Pro Ser  Asn Gly Pro Ser Ser  Ala His Thr 
    1340                 1345                 1350             


Gly Pro  Pro Ser Ser Ala Trp  Pro Thr Thr Ala Gly  Thr Ser Pro 
    1355                 1360                 1365             


Arg Thr  Arg Leu Pro Thr Ala  Ser Ala Ser Leu Pro  Pro Val Cys 
    1370                 1375                 1380             


Gly Glu  Lys Cys Leu Trp Ser  Pro Trp Met Asp Val  Ser Arg Pro 
    1385                 1390                 1395             


Gly Arg  Gly Thr Asp Ser Gly  Asp Phe Asp Thr Leu  Glu Asn Leu 
    1400                 1405                 1410             


Arg Ala  His Gly Tyr Arg Val  Cys Glu Ser Pro Arg  Ser Val Glu 
    1415                 1420                 1425             


Cys Arg  Ala Glu Asp Ala Pro  Gly Val Pro Leu Arg  Ala Leu Gly 
    1430                 1435                 1440             


Gln Arg  Val Gln Cys Ser Pro  Asp Val Gly Leu Thr  Cys Arg Asn 
    1445                 1450                 1455             


Arg Glu  Gln Ala Ser Gly Leu  Cys Tyr Asn Tyr Gln  Ile Arg Val 
    1460                 1465                 1470             


Gln Cys  Cys Thr Pro Leu Pro  Cys Ser Thr Ser Ser  Ser Pro Ala 
    1475                 1480                 1485             


Gln Thr  Thr Pro Pro Thr Thr  Ser Lys Thr Thr Glu  Thr Arg Ala 
    1490                 1495                 1500             


Ser Gly  Ser Ser Ala Pro Ser  Ser Thr Pro Gly Thr  Val Ser Leu 
    1505                 1510                 1515             


Ser Thr  Ala Arg Thr Thr Pro  Ala Pro Gly Thr Ala  Thr Ser Val 
    1520                 1525                 1530             


Lys Lys  Thr Phe Ser Thr Pro  Ser Pro Pro Pro Val  Pro Ala Thr 
    1535                 1540                 1545             


Ser Thr  Ser Ser Met Ser Thr  Thr Ala Pro Gly Thr  Ser Val Val 
    1550                 1555                 1560             


Ser Ser  Lys Pro Thr Pro Thr  Glu Pro Ser Thr Ser  Ser Cys Leu 
    1565                 1570                 1575             


Gln Glu  Leu Cys Thr Trp Thr  Glu Trp Ile Asp Gly  Ser Tyr Pro 
    1580                 1585                 1590             


Ala Pro  Gly Ile Asn Gly Gly  Asp Phe Asp Thr Phe  Gln Asn Leu 
    1595                 1600                 1605             


Arg Asp  Glu Gly Tyr Thr Phe  Cys Glu Ser Pro Arg  Ser Val Gln 
    1610                 1615                 1620             


Cys Arg  Ala Glu Ser Phe Pro  Asn Thr Pro Leu Ala  Asp Leu Gly 
    1625                 1630                 1635             


Gln Asp  Val Ile Cys Ser His  Thr Glu Gly Leu Ile  Cys Leu Asn 
    1640                 1645                 1650             


Lys Asn  Gln Leu Pro Pro Ile  Cys Tyr Asn Tyr Glu  Ile Arg Ile 
    1655                 1660                 1665             


Gln Cys  Cys Glu Thr Val Asn  Val Cys Arg Asp Ile  Thr Arg Leu 
    1670                 1675                 1680             


Pro Lys  Thr Val Ala Thr Thr  Arg Pro Thr Pro His  Pro Thr Gly 
    1685                 1690                 1695             


Ala Gln  Thr Gln Thr Thr Phe  Thr Thr His Met Pro  Ser Ala Ser 
    1700                 1705                 1710             


Thr Glu  Gln Pro Thr Ala Thr  Ser Arg Gly Gly Pro  Thr Ala Thr 
    1715                 1720                 1725             


Ser Val  Thr Gln Gly Thr His  Thr Thr Leu Val Thr  Arg Asn Cys 
    1730                 1735                 1740             


His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe Asp Val  Asp Phe Pro 
    1745                 1750                 1755             


Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu Thr Tyr  Asn Asn Ile 
    1760                 1765                 1770             


Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg Pro Glu  Glu Ile Thr 
    1775                 1780                 1785             


Arg Leu  Gln Cys Arg Ala Lys  Ser His Pro Glu Val  Ser Ile Glu 
    1790                 1795                 1800             


His Leu  Gly Gln Val Val Gln  Cys Ser Arg Glu Glu  Gly Leu Val 
    1805                 1810                 1815             


Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe Lys Met  Cys Leu Asn 
    1820                 1825                 1830             


Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr Pro Arg  Gly Cys His 
    1835                 1840                 1845             


Met Thr  Ser Thr Pro Gly Ser  Thr Ser Ser Ser Pro  Ala Gln Thr 
    1850                 1855                 1860             


Thr Pro  Ser Thr Thr Ser Lys  Thr Thr Glu Thr Gln  Ala Ser Gly 
    1865                 1870                 1875             


Ser Ser  Ala Pro Ser Ser Thr  Pro Gly Thr Val Ser  Leu Ser Thr 
    1880                 1885                 1890             


Ala Arg  Thr Thr Pro Ala Pro  Gly Thr Ala Thr Ser  Val Lys Lys 
    1895                 1900                 1905             


Thr Phe  Ser Thr Pro Ser Pro  Pro Pro Val Pro Ala  Thr Ser Thr 
    1910                 1915                 1920             


Ser Ser  Met Ser Thr Thr Ala  Pro Gly Thr Ser Val  Val Ser Ser 
    1925                 1930                 1935             


Lys Pro  Thr Pro Thr Glu Pro  Ser Thr Ser Ser Cys  Leu Gln Glu 
    1940                 1945                 1950             


Leu Cys  Thr Trp Thr Glu Trp  Ile Asp Gly Ser Tyr  Pro Ala Pro 
    1955                 1960                 1965             


Gly Ile  Asn Gly Gly Asp Phe  Asp Thr Phe Gln Asn  Leu Arg Asp 
    1970                 1975                 1980             


Glu Gly  Tyr Thr Phe Cys Glu  Ser Pro Arg Ser Val  Gln Cys Arg 
    1985                 1990                 1995             


Ala Glu  Ser Phe Pro Asn Thr  Pro Leu Ala Asp Leu  Gly Gln Asp 
    2000                 2005                 2010             


Val Ile  Cys Ser His Thr Glu  Gly Leu Ile Cys Leu  Asn Lys Asn 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ile Cys Tyr  Asn Tyr Glu Ile Arg  Ile Gln Cys 
    2030                 2035                 2040             


Cys Glu  Thr Val Asn Val Cys  Arg Asp Ile Thr Arg  Pro Pro Lys 
    2045                 2050                 2055             


Thr Val  Ala Thr Thr Arg Pro  Thr Pro His Pro Thr  Gly Ala Gln 
    2060                 2065                 2070             


Thr Gln  Thr Thr Phe Thr Thr  His Met Pro Ser Ala  Ser Thr Glu 
    2075                 2080                 2085             


Gln Pro  Thr Ala Thr Ser Arg  Gly Gly Pro Thr Ala  Thr Ser Val 
    2090                 2095                 2100             


Thr Gln  Gly Thr His Thr Thr  Pro Val Thr Arg Asn  Cys His Pro 
    2105                 2110                 2115             


Arg Cys  Thr Trp Thr Thr Trp  Phe Asp Val Asp Phe  Pro Ser Pro 
    2120                 2125                 2130             


Gly Pro  His Gly Gly Asp Lys  Glu Thr Tyr Asn Asn  Ile Ile Arg 
    2135                 2140                 2145             


Ser Gly  Glu Lys Ile Cys Arg  Arg Pro Glu Glu Ile  Thr Arg Leu 
    2150                 2155                 2160             


Gln Cys  Arg Ala Lys Ser His  Pro Glu Val Ser Ile  Glu His Leu 
    2165                 2170                 2175             


Gly Gln  Val Val Gln Cys Ser  Arg Glu Glu Gly Leu  Val Cys Arg 
    2180                 2185                 2190             


Asn Gln  Asp Gln Gln Gly Pro  Phe Lys Met Cys Leu  Asn Tyr Glu 
    2195                 2200                 2205             


Val Arg  Val Leu Cys Cys Glu  Thr Pro Lys Gly Cys  Pro Val Thr 
    2210                 2215                 2220             


Ser Thr  Pro Val Thr Ala Pro  Ser Thr Pro Ser Gly  Arg Ala Thr 
    2225                 2230                 2235             


Ser Pro  Thr Gln Ser Thr Ser  Ser Trp Gln Lys Ser  Arg Thr Thr 
    2240                 2245                 2250             


Thr Leu  Val Thr Thr Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr 
    2255                 2260                 2265             


Thr Tyr  Ala His Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Ala Arg 
    2270                 2275                 2280             


Thr Thr  Ser Ala Pro Thr Thr  Arg Thr Thr Ser Ala  Ser Pro Ala 
    2285                 2290                 2295             


Ser Thr  Thr Ser Gly Pro Gly  Asn Thr Pro Ser Pro  Val Pro Thr 
    2300                 2305                 2310             


Thr Ser  Thr Ile Ser Ala Pro  Thr Thr Ser Ile Thr  Ser Ala Pro 
    2315                 2320                 2325             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Ser Ser Thr  Thr Ser Gly 
    2330                 2335                 2340             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Ile Thr Ser 
    2345                 2350                 2355             


Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2360                 2365                 2370             


Ser Ala  Arg Thr Ser Ser Thr  Thr Ser Ala Thr Thr  Thr Ser Arg 
    2375                 2380                 2385             


Ile Ser  Gly Pro Glu Thr Thr  Pro Ser Pro Val Pro  Thr Thr Ser 
    2390                 2395                 2400             


Thr Thr  Ser Ala Thr Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    2405                 2410                 2415             


Ser Thr  Thr Ser Ala Pro Thr  Ser Ser Thr Thr Ser  Ser Pro Gln 
    2420                 2425                 2430             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Gly Pro 
    2435                 2440                 2445             


Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala 
    2450                 2455                 2460             


Pro Thr  Thr Arg Thr Thr Ser  Ala Pro Lys Ser Ser  Thr Thr Ser 
    2465                 2470                 2475             


Ala Ala  Thr Thr Ser Thr Thr  Ser Gly Pro Glu Thr  Thr Pro Arg 
    2480                 2485                 2490             


Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ser Pro Thr  Thr Ser Thr 
    2495                 2500                 2505             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Ser  Thr Thr Ser 
    2510                 2515                 2520             


Thr Thr  Ser Gly Ala Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    2525                 2530                 2535             


Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Ile 
    2540                 2545                 2550             


Ser Ser  Thr Thr Ser Ala Thr  Thr Thr Ser Thr Thr  Ser Gly Pro 
    2555                 2560                 2565             


Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala 
    2570                 2575                 2580             


Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Ala 
    2585                 2590                 2595             


Val Pro  Thr Thr Ser Ile Thr  Ser Ala Pro Thr Thr  Ser Thr Asn 
    2600                 2605                 2610             


Ser Ala  Pro Ile Ser Ser Thr  Thr Ser Ala Thr Thr  Thr Ser Arg 
    2615                 2620                 2625             


Ile Ser  Gly Pro Glu Thr Thr  Pro Ser Pro Val Pro  Thr Ala Ser 
    2630                 2635                 2640             


Thr Thr  Ser Ala Ser Thr Thr  Ser Thr Thr Ser Gly  Pro Gly Thr 
    2645                 2650                 2655             


Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr Ile Ser  Val Pro Thr 
    2660                 2665                 2670             


Thr Ser  Thr Thr Ser Ala Ser  Thr Thr Ser Thr Thr  Ser Ala Ser 
    2675                 2680                 2685             


Thr Thr  Ser Thr Thr Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val 
    2690                 2695                 2700             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    2705                 2710                 2715             


Ala Pro  Thr Thr Ser Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2720                 2725                 2730             


Ser Ala  Thr Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Pro Arg Arg 
    2735                 2740                 2745             


Thr Ser  Ala Pro Thr Thr Ser  Thr Ile Ser Ala Ser  Thr Thr Ser 
    2750                 2755                 2760             


Thr Thr  Ser Ala Thr Thr Thr  Ser Thr Thr Ser Ala  Thr Thr Thr 
    2765                 2770                 2775             


Ser Thr  Ile Ser Ala Pro Thr  Thr Ser Thr Thr Leu  Ser Pro Thr 
    2780                 2785                 2790             


Thr Ser  Thr Thr Ser Thr Thr  Ile Thr Ser Thr Thr  Ser Ala Pro 
    2795                 2800                 2805             


Ile Ser  Ser Thr Thr Ser Thr  Pro Gln Thr Ser Thr  Thr Ser Ala 
    2810                 2815                 2820             


Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Ser Ser Pro 
    2825                 2830                 2835             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr 
    2840                 2845                 2850             


Ser Ala  Pro Thr Thr Arg Thr  Thr Ser Val Pro Thr  Ser Ser Thr 
    2855                 2860                 2865             


Thr Ser  Thr Ala Thr Thr Ser  Thr Thr Ser Gly Pro  Gly Thr Thr 
    2870                 2875                 2880             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    2885                 2890                 2895             


Arg Thr  Thr Ser Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    2900                 2905                 2910             


Thr Ser  Thr Thr Ser Ala Pro  Thr Ser Ser Thr Thr  Ser Ala Thr 
    2915                 2920                 2925             


Thr Thr  Ser Thr Ile Ser Val  Pro Thr Thr Ser Thr  Thr Ser Val 
    2930                 2935                 2940             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Ile Ser 
    2945                 2950                 2955             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Ser Thr Thr  Ser Thr Thr 
    2960                 2965                 2970             


Ser Gly  Pro Gly Thr Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    2975                 2980                 2985             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser 
    2990                 2995                 3000             


Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Pro Ser Ala  Pro Thr Thr 
    3005                 3010                 3015             


Ser Thr  Thr Leu Ala Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    3020                 3025                 3030             


Thr Ser  Thr Thr Ser Thr Pro  Thr Ser Ser Thr Thr  Ser Ser Pro 
    3035                 3040                 3045             


Gln Thr  Ser Thr Thr Ser Ala  Ser Thr Thr Ser Ile  Thr Ser Gly 
    3050                 3055                 3060             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Thr Ser 
    3065                 3070                 3075             


Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Ala Thr Thr  Ser Thr Ile 
    3080                 3085                 3090             


Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    3095                 3100                 3105             


Thr Ser  Ala Ser Thr Ala Ser  Lys Thr Ser Gly Leu  Gly Thr Thr 
    3110                 3115                 3120             


Pro Ser  Pro Ile Pro Thr Thr  Ser Thr Thr Ser Pro  Pro Thr Thr 
    3125                 3130                 3135             


Ser Thr  Thr Ser Ala Ser Thr  Ala Ser Lys Thr Ser  Gly Pro Gly 
    3140                 3145                 3150             


Thr Thr  Pro Ser Pro Val Pro  Thr Thr Ser Thr Ile  Phe Ala Pro 
    3155                 3160                 3165             


Arg Thr  Ser Thr Thr Ser Ala  Ser Thr Thr Ser Thr  Thr Pro Gly 
    3170                 3175                 3180             


Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr Thr Ser  Thr Ala Ser 
    3185                 3190                 3195             


Val Ser  Lys Thr Ser Thr Ser  His Val Ser Ile Ser  Lys Thr Thr 
    3200                 3205                 3210             


His Ser  Gln Pro Val Thr Arg  Asp Cys His Leu Arg  Cys Thr Trp 
    3215                 3220                 3225             


Thr Lys  Trp Phe Asp Ile Asp  Phe Pro Ser Pro Gly  Pro His Gly 
    3230                 3235                 3240             


Gly Asp  Lys Glu Thr Tyr Asn  Asn Ile Ile Arg Ser  Gly Glu Lys 
    3245                 3250                 3255             


Ile Cys  Arg Arg Pro Glu Glu  Ile Thr Arg Leu Gln  Cys Arg Ala 
    3260                 3265                 3270             


Glu Ser  His Pro Glu Val Ser  Ile Glu His Leu Gly  Gln Val Val 
    3275                 3280                 3285             


Gln Cys  Ser Arg Glu Glu Gly  Leu Val Cys Arg Asn  Gln Asp Gln 
    3290                 3295                 3300             


Gln Gly  Pro Phe Lys Met Cys  Leu Asn Tyr Glu Val  Arg Val Leu 
    3305                 3310                 3315             


Cys Cys  Glu Thr Pro Lys Gly  Cys Pro Val Thr Ser  Thr Pro Val 
    3320                 3325                 3330             


Thr Ala  Pro Ser Thr Pro Ser  Gly Arg Ala Thr Ser  Pro Thr Gln 
    3335                 3340                 3345             


Ser Thr  Ser Ser Trp Gln Lys  Ser Arg Thr Thr Thr  Leu Val Thr 
    3350                 3355                 3360             


Thr Ser  Thr Thr Ser Thr Pro  Gln Thr Ser Thr Thr  Ser Ala Pro 
    3365                 3370                 3375             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Ala 
    3380                 3385                 3390             


Pro Thr  Thr Ser Thr Thr Ser  Thr Pro Gln Thr Ser  Ile Ser Ser 
    3395                 3400                 3405             


Ala Pro  Thr Ser Ser Thr Thr  Ser Ala Pro Thr Ser  Ser Thr Ile 
    3410                 3415                 3420             


Ser Ala  Arg Thr Thr Ser Ile  Ile Ser Ala Pro Thr  Thr Ser Thr 
    3425                 3430                 3435             


Thr Ser  Ser Pro Thr Thr Ser  Thr Thr Ser Ala Thr  Thr Thr Ser 
    3440                 3445                 3450             


Thr Thr  Ser Ala Pro Thr Ser  Ser Thr Thr Ser Thr  Pro Gln Thr 
    3455                 3460                 3465             


Ser Lys  Thr Ser Ala Ala Thr  Ser Ser Thr Thr Ser  Gly Ser Gly 
    3470                 3475                 3480             


Thr Thr  Pro Ser Pro Val Thr  Thr Thr Ser Thr Ala  Ser Val Ser 
    3485                 3490                 3495             


Lys Thr  Ser Thr Ser His Val  Ser Val Ser Lys Thr  Thr His Ser 
    3500                 3505                 3510             


Gln Pro  Val Thr Arg Asp Cys  His Pro Arg Cys Thr  Trp Thr Lys 
    3515                 3520                 3525             


Trp Phe  Asp Val Asp Phe Pro  Ser Pro Gly Pro His  Gly Gly Asp 
    3530                 3535                 3540             


Lys Glu  Thr Tyr Asn Asn Ile  Ile Arg Ser Gly Glu  Lys Ile Cys 
    3545                 3550                 3555             


Arg Arg  Pro Glu Glu Ile Thr  Arg Leu Gln Cys Arg  Ala Lys Ser 
    3560                 3565                 3570             


His Pro  Glu Val Ser Ile Glu  His Leu Gly Gln Val  Val Gln Cys 
    3575                 3580                 3585             


Ser Arg  Glu Glu Gly Leu Val  Cys Arg Asn Gln Asp  Gln Gln Gly 
    3590                 3595                 3600             


Pro Phe  Lys Met Cys Leu Asn  Tyr Glu Val Arg Val  Leu Cys Cys 
    3605                 3610                 3615             


Glu Thr  Pro Lys Gly Cys Pro  Val Thr Ser Thr Ser  Val Thr Ala 
    3620                 3625                 3630             


Pro Ser  Thr Pro Ser Gly Arg  Ala Thr Ser Pro Thr  Gln Ser Thr 
    3635                 3640                 3645             


Ser Ser  Trp Gln Lys Ser Arg  Thr Thr Thr Leu Val  Thr Ser Ser 
    3650                 3655                 3660             


Ile Thr  Ser Thr Thr Gln Thr  Ser Thr Thr Ser Ala  Pro Thr Thr 
    3665                 3670                 3675             


Ser Thr  Thr Pro Ala Ser Ile  Pro Ser Thr Thr Ser  Ala Pro Thr 
    3680                 3685                 3690             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    3695                 3700                 3705             


Thr Thr  Ser Thr Thr Ser Thr  Pro Gln Thr Thr Thr  Ser Ser Ala 
    3710                 3715                 3720             


Pro Thr  Ser Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Ile Ser 
    3725                 3730                 3735             


Ala Pro  Thr Thr Ser Thr Ile  Ser Ala Pro Thr Thr  Ser Thr Thr 
    3740                 3745                 3750             


Ser Ala  Pro Thr Ala Ser Thr  Thr Ser Ala Pro Thr  Ser Thr Ser 
    3755                 3760                 3765             


Ser Ala  Pro Thr Thr Asn Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    3770                 3775                 3780             


Thr Ser  Ala Pro Ile Thr Ser  Thr Ile Ser Ala Pro  Thr Thr Ser 
    3785                 3790                 3795             


Thr Thr  Ser Thr Pro Gln Thr  Ser Thr Ile Ser Ser  Pro Thr Thr 
    3800                 3805                 3810             


Ser Thr  Thr Ser Thr Pro Gln  Thr Ser Thr Thr Ser  Ser Pro Thr 
    3815                 3820                 3825             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Pro 
    3830                 3835                 3840             


Thr Thr  Ser Thr Thr Ser Thr  Pro Gln Thr Ser Ile  Ser Ser Ala 
    3845                 3850                 3855             


Pro Thr  Ser Ser Thr Thr Ser  Ala Pro Thr Ala Ser  Thr Ile Ser 
    3860                 3865                 3870             


Ala Pro  Thr Thr Ser Thr Thr  Ser Phe His Thr Thr  Ser Thr Thr 
    3875                 3880                 3885             


Ser Pro  Pro Thr Ser Ser Thr  Ser Ser Thr Pro Gln  Thr Ser Lys 
    3890                 3895                 3900             


Thr Ser  Ala Ala Thr Ser Ser  Thr Thr Ser Gly Ser  Gly Thr Thr 
    3905                 3910                 3915             


Pro Ser  Pro Val Pro Thr Thr  Ser Thr Ala Ser Val  Ser Lys Thr 
    3920                 3925                 3930             


Ser Thr  Ser His Val Ser Val  Ser Lys Thr Thr His  Ser Gln Pro 
    3935                 3940                 3945             


Val Thr  Arg Asp Cys His Pro  Arg Cys Thr Trp Thr  Lys Trp Phe 
    3950                 3955                 3960             


Asp Val  Asp Phe Pro Ser Pro  Gly Pro His Gly Gly  Asp Lys Glu 
    3965                 3970                 3975             


Thr Tyr  Asn Asn Ile Ile Arg  Ser Gly Glu Lys Ile  Cys Arg Arg 
    3980                 3985                 3990             


Pro Glu  Glu Ile Thr Arg Leu  Gln Cys Arg Ala Glu  Ser His Pro 
    3995                 4000                 4005             


Glu Val  Ser Ile Glu His Leu  Gly Gln Val Val Gln  Cys Ser Arg 
    4010                 4015                 4020             


Glu Glu  Gly Leu Val Cys Arg  Asn Gln Asp Gln Gln  Gly Pro Phe 
    4025                 4030                 4035             


Lys Met  Cys Leu Asn Tyr Glu  Val Arg Val Leu Cys  Cys Glu Thr 
    4040                 4045                 4050             


Pro Lys  Gly Cys Pro Val Thr  Ser Thr Pro Val Thr  Ala Pro Ser 
    4055                 4060                 4065             


Thr Pro  Ser Gly Arg Ala Thr  Ser Pro Thr Gln Ser  Thr Ser Ser 
    4070                 4075                 4080             


Trp Gln  Lys Ser Arg Thr Thr  Thr Leu Val Thr Thr  Ser Thr Thr 
    4085                 4090                 4095             


Ser Thr  Pro Gln Thr Ser Thr  Thr Ser Ala Pro Thr  Thr Ser Thr 
    4100                 4105                 4110             


Ile Pro  Ala Ser Thr Pro Ser  Thr Thr Ser Ala Pro  Thr Thr Ser 
    4115                 4120                 4125             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Pro Thr His 
    4130                 4135                 4140             


Arg Thr  Thr Ser Gly Pro Thr  Thr Ser Thr Thr Leu  Ala Pro Thr 
    4145                 4150                 4155             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Asn  Ser Ala Pro 
    4160                 4165                 4170             


Thr Thr  Ser Thr Ile Ser Ala  Ser Thr Thr Ser Thr  Ile Ser Ala 
    4175                 4180                 4185             


Pro Thr  Thr Ser Thr Ile Ser  Ser Pro Thr Ser Ser  Thr Thr Ser 
    4190                 4195                 4200             


Thr Pro  Gln Thr Ser Lys Thr  Ser Ala Ala Thr Ser  Ser Thr Thr 
    4205                 4210                 4215             


Ser Gly  Ser Gly Thr Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    4220                 4225                 4230             


Thr Ser  Ala Ser Thr Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser 
    4235                 4240                 4245             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Ser Thr 
    4250                 4255                 4260             


Ser Thr  Thr Ser Ala Ala Thr  Thr Ser Thr Thr Ser  Ala Pro Thr 
    4265                 4270                 4275             


Thr Arg  Thr Thr Ser Ala Pro  Thr Ser Ser Met Thr  Ser Gly Pro 
    4280                 4285                 4290             


Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr Ser Thr  Thr Ser Ala 
    4295                 4300                 4305             


Pro Thr  Thr Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro 
    4310                 4315                 4320             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Pro Ile Thr  Ser Thr Thr 
    4325                 4330                 4335             


Ser Gly  Pro Gly Ser Thr Pro  Ser Pro Val Pro Thr  Thr Ser Thr 
    4340                 4345                 4350             


Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser Ala Ser  Thr Ala Ser 
    4355                 4360                 4365             


Thr Thr  Ser Gly Pro Gly Thr  Thr Pro Ser Pro Val  Pro Thr Thr 
    4370                 4375                 4380             


Ser Thr  Thr Ser Ala Pro Thr  Thr Arg Thr Thr Ser  Ala Ser Thr 
    4385                 4390                 4395             


Ala Ser  Thr Thr Ser Gly Pro  Gly Ser Thr Pro Ser  Pro Val Pro 
    4400                 4405                 4410             


Thr Thr  Ser Thr Thr Ser Ala  Pro Thr Thr Arg Thr  Thr Pro Ala 
    4415                 4420                 4425             


Ser Thr  Ala Ser Thr Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro 
    4430                 4435                 4440             


Val Pro  Thr Thr Ser Thr Thr  Ser Ala Ser Thr Thr  Ser Thr Ile 
    4445                 4450                 4455             


Ser Leu  Pro Thr Thr Ser Thr  Thr Ser Ala Pro Ile  Thr Ser Met 
    4460                 4465                 4470             


Thr Ser  Gly Pro Gly Thr Thr  Pro Ser Pro Val Pro  Thr Thr Ser 
    4475                 4480                 4485             


Thr Thr  Ser Ala Pro Thr Thr  Ser Thr Thr Ser Ala  Ser Thr Ala 
    4490                 4495                 4500             


Ser Thr  Thr Ser Gly Pro Gly  Thr Thr Pro Ser Pro  Val Pro Thr 
    4505                 4510                 4515             


Thr Ser  Thr Thr Ser Ala Pro  Thr Thr Ser Thr Thr  Ser Ala Ser 
    4520                 4525                 4530             


Thr Ala  Ser Thr Thr Ser Gly  Pro Gly Thr Ser Leu  Ser Pro Val 
    4535                 4540                 4545             


Pro Thr  Thr Ser Thr Thr Ser  Ala Pro Thr Thr Ser  Thr Thr Ser 
    4550                 4555                 4560             


Gly Pro  Gly Thr Thr Pro Ser  Pro Val Pro Thr Thr  Ser Thr Thr 
    4565                 4570                 4575             


Ser Ala  Pro Thr Thr Ser Thr  Thr Ser Gly Pro Gly  Thr Thr Pro 
    4580                 4585                 4590             


Ser Pro  Val Pro Thr Thr Ser  Thr Thr Pro Val Ser  Lys Thr Ser 
    4595                 4600                 4605             


Thr Ser  His Leu Ser Val Ser  Lys Thr Thr His Ser  Gln Pro Val 
    4610                 4615                 4620             


Thr Ser  Asp Cys His Pro Leu  Cys Ala Trp Thr Lys  Trp Phe Asp 
    4625                 4630                 4635             


Val Asp  Phe Pro Ser Pro Gly  Pro His Gly Gly Asp  Lys Glu Thr 
    4640                 4645                 4650             


Tyr Asn  Asn Ile Ile Arg Ser  Gly Glu Lys Ile Cys  Arg Arg Pro 
    4655                 4660                 4665             


Glu Glu  Ile Thr Arg Leu Gln  Cys Arg Ala Glu Ser  His Pro Glu 
    4670                 4675                 4680             


Val Asn  Ile Glu His Leu Gly  Gln Val Val Gln Cys  Ser Arg Glu 
    4685                 4690                 4695             


Glu Gly  Leu Val Cys Arg Asn  Gln Asp Gln Gln Gly  Pro Phe Lys 
    4700                 4705                 4710             


Met Cys  Leu Asn Tyr Glu Val  Arg Val Leu Cys Cys  Glu Thr Pro 
    4715                 4720                 4725             


Arg Gly  Cys Pro Val Thr Ser  Val Thr Pro Tyr Gly  Thr Ser Pro 
    4730                 4735                 4740             


Thr Asn  Ala Leu Tyr Pro Ser  Leu Ser Thr Ser Met  Val Ser Ala 
    4745                 4750                 4755             


Ser Val  Ala Ser Thr Ser Val  Ala Ser Ser Ser Val  Ala Ser Ser 
    4760                 4765                 4770             


Ser Val  Ala Tyr Ser Thr Gln  Thr Cys Phe Cys Asn  Val Ala Asp 
    4775                 4780                 4785             


Arg Leu  Tyr Pro Ala Gly Ser  Thr Ile Tyr Arg His  Arg Asp Leu 
    4790                 4795                 4800             


Ala Gly  His Cys Tyr Tyr Ala  Leu Cys Ser Gln Asp  Cys Gln Val 
    4805                 4810                 4815             


Val Arg  Gly Val Asp Ser Asp  Cys Pro Ser Thr Thr  Leu Pro Pro 
    4820                 4825                 4830             


Ala Pro  Ala Thr Ser Pro Ser  Ile Ser Thr Ser Glu  Pro Val Thr 
    4835                 4840                 4845             


Glu Leu  Gly Cys Pro Asn Ala  Val Pro Pro Arg Lys  Lys Gly Glu 
    4850                 4855                 4860             


Thr Trp  Ala Thr Pro Asn Cys  Ser Glu Ala Thr Cys  Glu Gly Asn 
    4865                 4870                 4875             


Asn Val  Ile Ser Leu Arg Pro  Arg Thr Cys Pro Arg  Val Glu Lys 
    4880                 4885                 4890             


Pro Thr  Cys Ala Asn Gly Tyr  Pro Ala Val Lys Val  Ala Asp Gln 
    4895                 4900                 4905             


Asp Gly  Cys Cys His His Tyr  Gln Cys Gln Cys Val  Cys Ser Gly 
    4910                 4915                 4920             


Trp Gly  Asp Pro His Tyr Ile  Thr Phe Asp Gly Thr  Tyr Tyr Thr 
    4925                 4930                 4935             


Phe Leu  Asp Asn Cys Thr Tyr  Val Leu Val Gln Gln  Ile Val Pro 
    4940                 4945                 4950             


Val Tyr  Gly His Phe Arg Val  Leu Val Asp Asn Tyr  Phe Cys Gly 
    4955                 4960                 4965             


Ala Glu  Asp Gly Leu Ser Cys  Pro Arg Ser Ile Ile  Leu Glu Tyr 
    4970                 4975                 4980             


His Gln  Asp Arg Val Val Leu  Thr Arg Lys Pro Val  His Gly Val 
    4985                 4990                 4995             


Met Thr  Asn Glu Ile Ile Phe  Asn Asn Lys Val Val  Ser Pro Gly 
    5000                 5005                 5010             


Phe Arg  Lys Asn Gly Ile Val  Val Ser Arg Ile Gly  Val Lys Met 
    5015                 5020                 5025             


Tyr Ala  Thr Ile Pro Glu Leu  Gly Val Gln Val Met  Phe Ser Gly 
    5030                 5035                 5040             


Leu Ile  Phe Ser Val Glu Val  Pro Phe Ser Lys Phe  Ala Asn Asn 
    5045                 5050                 5055             


Thr Glu  Gly Gln Cys Gly Thr  Cys Thr Asn Asp Arg  Lys Asp Glu 
    5060                 5065                 5070             


Cys Arg  Thr Pro Arg Gly Thr  Val Val Ala Ser Cys  Ser Glu Met 
    5075                 5080                 5085             


Ser Gly  Leu Trp Asn Val Ser  Ile Pro Asp Gln Pro  Ala Cys His 
    5090                 5095                 5100             


Arg Pro  His Pro Thr Pro Thr  Thr Val Gly Pro Thr  Thr Val Gly 
    5105                 5110                 5115             


Ser Thr  Thr Val Gly Pro Thr  Thr Val Gly Ser Thr  Thr Val Gly 
    5120                 5125                 5130             


Pro Thr  Thr Pro Pro Ala Pro  Cys Leu Pro Ser Pro  Ile Cys Gln 
    5135                 5140                 5145             


Leu Ile  Leu Ser Lys Val Phe  Glu Pro Cys His Thr  Val Ile Pro 
    5150                 5155                 5160             


Pro Leu  Leu Phe Tyr Glu Gly  Cys Val Phe Asp Arg  Cys His Met 
    5165                 5170                 5175             


Thr Asp  Leu Asp Val Val Cys  Ser Ser Leu Glu Leu  Tyr Ala Ala 
    5180                 5185                 5190             


Leu Cys  Ala Ser His Asp Ile  Cys Ile Asp Trp Arg  Gly Arg Thr 
    5195                 5200                 5205             


Gly His  Met Cys Pro Phe Thr  Cys Pro Ala Asp Lys  Val Tyr Gln 
    5210                 5215                 5220             


Pro Cys  Gly Pro Ser Asn Pro  Ser Tyr Cys Tyr Gly  Asn Asp Ser 
    5225                 5230                 5235             


Ala Ser  Leu Gly Ala Leu Pro  Glu Ala Gly Pro Ile  Thr Glu Gly 
    5240                 5245                 5250             


Cys Phe  Cys Pro Glu Gly Met  Thr Leu Phe Ser Thr  Ser Ala Gln 
    5255                 5260                 5265             


Val Cys  Val Pro Thr Gly Cys  Pro Arg Cys Leu Gly  Pro His Gly 
    5270                 5275                 5280             


Glu Pro  Val Lys Val Gly His  Thr Val Gly Met Asp  Cys Gln Glu 
    5285                 5290                 5295             


Cys Thr  Cys Glu Ala Ala Thr  Trp Thr Leu Thr Cys  Arg Pro Lys 
    5300                 5305                 5310             


Leu Cys  Pro Leu Pro Pro Ala  Cys Pro Leu Pro Gly  Phe Val Pro 
    5315                 5320                 5325             


Val Pro  Ala Ala Pro Gln Ala  Gly Gln Cys Cys Pro  Gln Tyr Ser 
    5330                 5335                 5340             


Cys Ala  Cys Asn Thr Ser Arg  Cys Pro Ala Pro Val  Gly Cys Pro 
    5345                 5350                 5355             


Glu Gly  Ala Arg Ala Ile Pro  Thr Tyr Gln Glu Gly  Ala Cys Cys 
    5360                 5365                 5370             


Pro Val  Gln Asn Cys Ser Trp  Thr Val Cys Ser Ile  Asn Gly Thr 
    5375                 5380                 5385             


Leu Tyr  Gln Pro Gly Ala Val  Val Ser Ser Ser Leu  Cys Glu Thr 
    5390                 5395                 5400             


Cys Arg  Cys Glu Leu Pro Gly  Gly Pro Pro Ser Asp  Ala Phe Val 
    5405                 5410                 5415             


Val Ser  Cys Glu Thr Gln Ile  Cys Asn Thr His Cys  Pro Val Gly 
    5420                 5425                 5430             


Phe Glu  Tyr Gln Glu Gln Ser  Gly Gln Cys Cys Gly  Thr Cys Val 
    5435                 5440                 5445             


Gln Val  Ala Cys Val Thr Asn  Thr Ser Lys Ser Pro  Ala His Leu 
    5450                 5455                 5460             


Phe Tyr  Pro Gly Glu Thr Trp  Ser Asp Ala Gly Asn  His Cys Val 
    5465                 5470                 5475             


Thr His  Gln Cys Glu Lys His  Gln Asp Gly Leu Val  Val Val Thr 
    5480                 5485                 5490             


Thr Lys  Lys Ala Cys Pro Pro  Leu Ser Cys Ser Leu  Asp Glu Ala 
    5495                 5500                 5505             


Arg Met  Ser Lys Asp Gly Cys  Cys Arg Phe Cys Pro  Pro Pro Pro 
    5510                 5515                 5520             


Pro Pro  Tyr Gln Asn Gln Ser  Thr Cys Ala Val Tyr  His Arg Ser 
    5525                 5530                 5535             


Leu Ile  Ile Gln Gln Gln Gly  Cys Ser Ser Ser Glu  Pro Val Arg 
    5540                 5545                 5550             


Leu Ala  Tyr Cys Arg Gly Asn  Cys Gly Asp Ser Ser  Ser Met Tyr 
    5555                 5560                 5565             


Ser Leu  Glu Gly Asn Thr Val  Glu His Arg Cys Gln  Cys Cys Gln 
    5570                 5575                 5580             


Glu Leu  Arg Thr Ser Leu Arg  Asn Val Thr Leu His  Cys Thr Asp 
    5585                 5590                 5595             


Gly Ser  Ser Arg Ala Phe Ser  Tyr Thr Glu Val Glu  Glu Cys Gly 
    5600                 5605                 5610             


Cys Met  Gly Arg Arg Cys Pro  Ala Pro Gly Asp Thr  Gln His Ser 
    5615                 5620                 5625             


Glu Glu  Ala Glu Pro Glu Pro  Ser Gln Glu Ala Glu  Ser Gly Ser 
    5630                 5635                 5640             


Trp Glu  Arg Gly Val Pro Val  Ser Pro Met His 
    5645                 5650                 


<210>  40
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD amino acid sequence

<400>  40

Val Thr Ala Ala Lys Gly Arg Ile Ile Gly Tyr Val Pro Gly Trp Lys 
1               5                   10                  15      


Thr Pro Pro Ala Ala Gln Glu Leu Ala Ser Ala Gly Tyr Thr His Val 
            20                  25                  30          


Met Ile Ala Phe Gly Val Phe Ser Thr Asn Thr Pro Gly Val Ile Val 
        35                  40                  45              


Pro Ala Phe Glu Thr Ile Thr Lys Glu Tyr Ile Gln Ser Leu His Gln 
    50                  55                  60                  


Ala Gly Ile Lys Val Ile Leu Ser Leu Gly Gly Ala Leu Thr Ser Ile 
65                  70                  75                  80  


Pro Asn Thr Thr Val Asp Phe His Gln Val Leu Val Ala Ser Ser Ser 
                85                  90                  95      


Pro Glu Ala Phe Lys Gln Thr Phe Ile Asn Ser Leu Lys Glu Leu Ile 
            100                 105                 110         


Ser Gln Tyr Gly Phe Asp Gly Phe Asp Thr Asp Ile Glu His Gly Ile 
        115                 120                 125             


Asn Ala Ser Gly Ser Phe Ser Gln Pro Gln Gly Asp Ile Ala Val Leu 
    130                 135                 140                 


Ala Ser Ile Ile Asn Thr Met Tyr Ser Gln Asn Ser Ser Leu Leu Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Gln Val Ala Asn Ile Ala Ala Thr Ser Gly Phe Asp 
                165                 170                 175     


Gln Thr Trp Gly Asn Tyr Ala Ser Leu Ile Met Gln Thr His Gln Ser 
            180                 185                 190         


Leu Ala Trp Val Gly Ile Gln Leu Tyr Asn Thr Gly Cys Ala Phe Gly 
        195                 200                 205             


Ile Asp Gln Val Cys Tyr Gly Pro Thr Pro Thr Asp Thr Pro Asp Phe 
    210                 215                 220                 


Ser Val Ala Met Ala Thr Asp Leu Leu Glu Asn Trp Pro Ala Thr Val 
225                 230                 235                 240 


Asn Gly Arg Pro Thr Gly Phe Gln Pro Tyr Ile Ser Tyr Leu Arg Pro 
                245                 250                 255     


Ser Gln Ile Val Ile Gly Tyr Pro Ser Pro Asn Ala Ser Gly Gly Ser 
            260                 265                 270         


Asp Gly Ser Pro Val Thr Pro Thr Thr Thr Ile Lys Arg Ala Ile Gln 
        275                 280                 285             


Cys Leu Lys Thr Ala Ile Ala Gly Asn Thr Ser Cys Gly Val Tyr Val 
    290                 295                 300                 


Pro Pro Arg Ala Tyr Gly Asn Ile Gly Gly Val Phe Asn Trp Glu Val 
305                 310                 315                 320 


Thr Tyr Asp Lys Asn Asn Gln Phe Lys Phe Ala Lys Glu Leu Lys Asn 
                325                 330                 335     


Cys Ala Ile Asn Gly Val Cys Glu 
            340                 


<210>  41
<211>  1035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChiA-CTD nucleic acid sequence

<400>  41
gtaaccgctg caaaagggcg tattattggt tacgtaccgg gatggaaaac tccacctgcc       60

gctcaagagt tggctagcgc gggttatact catgtcatga ttgctttcgg cgtatttagt      120

accaatactc cgggtgttat tgttcctgct tttgaaacaa taaccaaaga atatattcag      180

tctcttcatc aagccgggat taaagttatt ctttctttag gtggtgcgtt aactagtatt      240

cccaatacaa cagtagattt tcaccaggtt ttagtagctt cttcttcacc agaggcattt      300

aaacaaacat ttatcaactc tttaaaggag ttaatttctc aatatggttt tgatgggttt      360

gatacagata ttgagcatgg tattaacgct agcggttcct tttctcaacc acagggtgac      420

attgctgtct tagcaagcat tatcaatacg atgtacagcc aaaattcttc tctgctaatt      480

actctgacac ctcaagtggc taatattgct gcaacaagcg gtttcgacca aacctggggg      540

aattatgcct ctttaattat gcaaacccat cagtctttag cgtgggtagg tatccagctt      600

tacaatacag gatgtgcttt cggaattgat caagtatgct atggtcctac accaactgat      660

acccctgatt tttcagtagc tatggctacc gatttattgg agaattggcc agcaacggtc      720

aatggacgtc ctacaggatt tcaaccttat attagctatt taagaccttc ccaaattgtc      780

attggttatc catctccaaa tgctagtggt ggcagtgacg gttcaccggt tactccgaca      840

accacaatca agcgggctat tcagtgcctt aagacagcaa ttgccggtaa taccagttgt      900

ggtgtttatg ttccgccaag agcttatggg aatatcggtg gtgtatttaa ctgggaagta      960

acttatgata agaacaatca attcaaattt gcaaaagaat tgaaaaattg tgctattaat     1020

ggtgtttgtg agtaa                                                      1035


