                         SEQUENCE LISTING



<110>  Sciomics GmbH

 

<120>  Prediction and early diagnosis of acute kidney injury by a 

       protein signature



<130>  SC0002P-EP



<160>  304   



<170>  PatentIn version 3.5



<210>  1

<211>  604

<212>  PRT

<213>  Homo sapiens



<400>  1



Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 

1               5                   10                  15      





Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 

            20                  25                  30          





Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 

        35                  40                  45              





Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 

    50                  55                  60                  





Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 

65                  70                  75                  80  





Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 

                85                  90                  95      





Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 

            100                 105                 110         





Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 

        115                 120                 125             





Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 

    130                 135                 140                 





Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 

145                 150                 155                 160 





Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 

                165                 170                 175     





Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 

            180                 185                 190         





His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 

        195                 200                 205             





Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 

    210                 215                 220                 





Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 

225                 230                 235                 240 





Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 

                245                 250                 255     





Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 

            260                 265                 270         





Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 

        275                 280                 285             





Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 

    290                 295                 300                 





Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 

305                 310                 315                 320 





Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 

                325                 330                 335     





His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 

            340                 345                 350         





Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 

        355                 360                 365             





Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 

    370                 375                 380                 





Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 

385                 390                 395                 400 





Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 

                405                 410                 415     





Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 

            420                 425                 430         





Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 

        435                 440                 445             





Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 

    450                 455                 460                 





Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 

465                 470                 475                 480 





Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 

                485                 490                 495     





Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 

            500                 505                 510         





Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 

        515                 520                 525             





Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 

    530                 535                 540                 





Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 

545                 550                 555                 560 





Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 

                565                 570                 575     





Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 

            580                 585                 590         





Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 

        595                 600                 





<210>  2

<211>  185

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 

1               5                   10                  15      





Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 

            20                  25                  30          





Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 

        35                  40                  45              





Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 

    50                  55                  60                  





Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 

65                  70                  75                  80  





Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 

                85                  90                  95      





Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 

            100                 105                 110         





Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 

        115                 120                 125             





Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 

    130                 135                 140                 





Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 

145                 150                 155                 160 





Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 

                165                 170                 175     





Ala Val Gln Arg Thr Leu Leu Glu Lys 

            180                 185 





<210>  3

<211>  160

<212>  PRT

<213>  Homo sapiens



<400>  3



Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 

1               5                   10                  15      





Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 

            20                  25                  30          





Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 

        35                  40                  45              





Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 

    50                  55                  60                  





Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 

65                  70                  75                  80  





Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 

                85                  90                  95      





Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 

            100                 105                 110         





Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 

        115                 120                 125             





Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 

    130                 135                 140                 





Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Asp Gly 

145                 150                 155                 160 





<210>  4

<211>  169

<212>  PRT

<213>  Homo sapiens



<400>  4



Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 

1               5                   10                  15      





Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 

            20                  25                  30          





Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 

        35                  40                  45              





Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 

    50                  55                  60                  





Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 

65                  70                  75                  80  





Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 

                85                  90                  95      





Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 

            100                 105                 110         





Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 

        115                 120                 125             





Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 

    130                 135                 140                 





Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 

145                 150                 155                 160 





Ala Val Gln Arg Thr Leu Leu Glu Lys 

                165                 





<210>  5

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  5



Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 

1               5                   10                  15      





Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 

            20                  25                  30          





Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 

        35                  40                  45              





Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 

    50                  55                  60                  





Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 

65                  70                  75                  80  





Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 

                85                  90                  95      





Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 

            100                 105                 110         





Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 

        115                 120                 125             





Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 

    130                 135                 140                 





Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 

145                 150                 155                 160 





Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 

                165                 170                 175     





Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 

            180                 185                 190         





Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 

        195                 200                 205             





Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 

    210                 215                 220                 





Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 

225                 230                 235                 240 





Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 

                245                 250                 255     





Asn 

    





<210>  6

<211>  335

<212>  PRT

<213>  Homo sapiens



<400>  6



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 

65                  70                  75                  80  





Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 

                85                  90                  95      





Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 

            100                 105                 110         





Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 

        115                 120                 125             





Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 

    130                 135                 140                 





Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 

145                 150                 155                 160 





Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 

                165                 170                 175     





Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 

            180                 185                 190         





Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 

        195                 200                 205             





Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 

    210                 215                 220                 





Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 

225                 230                 235                 240 





Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 

                245                 250                 255     





Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 

            260                 265                 270         





Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 

        275                 280                 285             





Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 

    290                 295                 300                 





Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 

305                 310                 315                 320 





Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 

                325                 330                 335 





<210>  7

<211>  103

<212>  PRT

<213>  Homo sapiens



<400>  7



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Asp Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr 

65                  70                  75                  80  





Pro Ser Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val 

                85                  90                  95      





Phe Phe Phe Cys Gln Phe His 

            100             





<210>  8

<211>  86

<212>  PRT

<213>  Homo sapiens



<400>  8



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Asp Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr 

65                  70                  75                  80  





Pro Ser Ala Lys Arg Lys 

                85      





<210>  9

<211>  149

<212>  PRT

<213>  Homo sapiens



<400>  9



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 

65                  70                  75                  80  





Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 

                85                  90                  95      





Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 

            100                 105                 110         





Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 

        115                 120                 125             





Ala Lys Arg Lys Asp Pro Asp Leu Thr Trp Gly Gly Phe Val Phe Phe 

    130                 135                 140                 





Phe Cys Gln Phe His 

145                 





<210>  10

<211>  132

<212>  PRT

<213>  Homo sapiens



<400>  10



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 

65                  70                  75                  80  





Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 

                85                  90                  95      





Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Asp 

            100                 105                 110         





Val Asn Met Glu Ser Ser Arg Asn Ala His Ser Pro Ala Thr Pro Ser 

        115                 120                 125             





Ala Lys Arg Lys 

    130         





<210>  11

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  11



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 

65                  70                  75                  80  





Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 

                85                  90                  95      





Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 

            100                 105                 110         





Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 

        115                 120                 125             





Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 

    130                 135                 140                 





Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 

145                 150                 155                 160 





Ser Asn Thr Lys Cys Lys Glu Glu Val Lys Arg Lys Glu Val Gln Lys 

                165                 170                 175     





Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly Ser His Glu Ser Pro 

            180                 185                 190         





Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu Ser Asp Val Asp Leu 

        195                 200                 205             





Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met Thr Leu Ser Gln Val 

    210                 215                 220                 





Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu Ala Lys Ile Asp Glu 

225                 230                 235                 240 





Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu Gln Lys Val Gln Leu 

                245                 250                 255     





Leu Arg Asn Trp His Gln Leu His Gly Lys Lys Glu Ala Tyr Asp Thr 

            260                 265                 270         





Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys Thr Leu Ala Glu Lys 

        275                 280                 285             





Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser Asp Ser Glu Asn Ser 

    290                 295                 300                 





Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 

305                 310                 





<210>  12

<211>  220

<212>  PRT

<213>  Homo sapiens



<400>  12



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 

65                  70                  75                  80  





Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 

                85                  90                  95      





Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 

            100                 105                 110         





Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 

        115                 120                 125             





Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 

    130                 135                 140                 





Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 

145                 150                 155                 160 





Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 

                165                 170                 175     





Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 

            180                 185                 190         





Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 

        195                 200                 205             





Ser His Glu Ser Pro Thr Leu Asn Pro Met Leu Thr 

    210                 215                 220 





<210>  13

<211>  189

<212>  PRT

<213>  Homo sapiens



<400>  13



Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 

1               5                   10                  15      





Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 

            20                  25                  30          





Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 

        35                  40                  45              





Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 

    50                  55                  60                  





Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 

65                  70                  75                  80  





His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 

                85                  90                  95      





Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 

            100                 105                 110         





Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 

        115                 120                 125             





Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 

    130                 135                 140                 





Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 

145                 150                 155                 160 





Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 

                165                 170                 175     





Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 

            180                 185                 





<210>  14

<211>  385

<212>  PRT

<213>  Homo sapiens



<400>  14



Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 

1               5                   10                  15      





His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 

            20                  25                  30          





Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 

        35                  40                  45              





Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 

    50                  55                  60                  





Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 

65                  70                  75                  80  





Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 

                85                  90                  95      





Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 

            100                 105                 110         





Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 

        115                 120                 125             





Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 

    130                 135                 140                 





Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 

145                 150                 155                 160 





Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 

                165                 170                 175     





Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 

            180                 185                 190         





Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 

        195                 200                 205             





Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 

    210                 215                 220                 





Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 

225                 230                 235                 240 





Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 

                245                 250                 255     





Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 

            260                 265                 270         





Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 

        275                 280                 285             





Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 

    290                 295                 300                 





Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 

305                 310                 315                 320 





His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 

                325                 330                 335     





Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 

            340                 345                 350         





Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 

        355                 360                 365             





Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 

    370                 375                 380                 





Ser 

385 





<210>  15

<211>  269

<212>  PRT

<213>  Homo sapiens



<400>  15



Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 

1               5                   10                  15      





His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp 

            20                  25                  30          





Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr 

        35                  40                  45              





Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu 

    50                  55                  60                  





Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp 

65                  70                  75                  80  





Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 

                85                  90                  95      





Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 

            100                 105                 110         





Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 

        115                 120                 125             





Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 

    130                 135                 140                 





Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 

145                 150                 155                 160 





Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 

                165                 170                 175     





Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 

            180                 185                 190         





Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 

        195                 200                 205             





Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 

    210                 215                 220                 





Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 

225                 230                 235                 240 





Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 

                245                 250                 255     





Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 

            260                 265                 





<210>  16

<211>  176

<212>  PRT

<213>  Homo sapiens



<400>  16



Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala 

1               5                   10                  15      





Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val 

            20                  25                  30          





Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys 

        35                  40                  45              





Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg 

    50                  55                  60                  





Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn 

65                  70                  75                  80  





Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser 

                85                  90                  95      





Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His 

            100                 105                 110         





Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val 

        115                 120                 125             





Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp 

    130                 135                 140                 





Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly 

145                 150                 155                 160 





Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 

                165                 170                 175     





<210>  17

<211>  205

<212>  PRT

<213>  Homo sapiens



<400>  17



Met Lys Gln Ser Asp Ala Ser Pro Gln Glu Arg Val Asp Ser Asp Asp 

1               5                   10                  15      





Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr 

            20                  25                  30          





Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys Ser 

        35                  40                  45              





Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser 

    50                  55                  60                  





Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp 

65                  70                  75                  80  





Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val 

                85                  90                  95      





Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn Met 

            100                 105                 110         





Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys Gly 

        115                 120                 125             





Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala Ala 

    130                 135                 140                 





Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val Thr 

145                 150                 155                 160 





Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu Asp 

                165                 170                 175     





Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser Gly Gln His Gln 

            180                 185                 190         





Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser Ser 

        195                 200                 205 





<210>  18

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  18



Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 

1               5                   10                  15      





Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 

            20                  25                  30          





Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 

        35                  40                  45              





Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 

    50                  55                  60                  





Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 

65                  70                  75                  80  





Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 

                85                  90                  95      





Pro Lys Leu 

            





<210>  19

<211>  228

<212>  PRT

<213>  Homo sapiens



<400>  19



Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 

1               5                   10                  15      





Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 

            20                  25                  30          





Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 

        35                  40                  45              





Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 

    50                  55                  60                  





Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 

65                  70                  75                  80  





Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 

                85                  90                  95      





Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 

            100                 105                 110         





His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 

        115                 120                 125             





Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 

    130                 135                 140                 





Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 

145                 150                 155                 160 





Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 

                165                 170                 175     





Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 

            180                 185                 190         





Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 

        195                 200                 205             





Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 

    210                 215                 220                 





Arg Glu Met Val 

225             





<210>  20

<211>  259

<212>  PRT

<213>  Homo sapiens



<400>  20



Met Ala Ala Leu Met Arg Ser Lys Asp Ser Ser Cys Cys Leu Leu Leu 

1               5                   10                  15      





Leu Ala Ala Val Leu Met Val Glu Ser Ser Gln Ile Gly Ser Ser Arg 

            20                  25                  30          





Ala Lys Leu Asn Ser Ile Lys Ser Ser Leu Gly Gly Glu Thr Pro Gly 

        35                  40                  45              





Gln Ala Ala Asn Arg Ser Ala Gly Met Tyr Gln Gly Leu Ala Phe Gly 

    50                  55                  60                  





Gly Ser Lys Lys Gly Lys Asn Leu Gly Gln Ala Tyr Pro Cys Ser Ser 

65                  70                  75                  80  





Asp Lys Glu Cys Glu Val Gly Arg Tyr Cys His Ser Pro His Gln Gly 

                85                  90                  95      





Ser Ser Ala Cys Met Val Cys Arg Arg Lys Lys Lys Arg Cys His Arg 

            100                 105                 110         





Asp Gly Met Cys Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile 

        115                 120                 125             





Pro Val Thr Glu Ser Ile Leu Thr Pro His Ile Pro Ala Leu Asp Gly 

    130                 135                 140                 





Thr Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu 

145                 150                 155                 160 





Gly Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys 

                165                 170                 175     





Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly 

            180                 185                 190         





Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu 

        195                 200                 205             





His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly 

    210                 215                 220                 





Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys 

225                 230                 235                 240 





Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys 

                245                 250                 255     





Gln Lys Ile 

            





<210>  21

<211>  724

<212>  PRT

<213>  Homo sapiens



<400>  21



Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 

1               5                   10                  15      





Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 

            20                  25                  30          





Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 

        35                  40                  45              





Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 

    50                  55                  60                  





Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Glu Ser Gln Lys Asn 

65                  70                  75                  80  





Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu Gln 

                85                  90                  95      





Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu Leu 

            100                 105                 110         





Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr Ser 

        115                 120                 125             





Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu Thr 

    130                 135                 140                 





Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn Gln 

145                 150                 155                 160 





Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn Lys 

                165                 170                 175     





Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met Glu 

            180                 185                 190         





Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly Lys 

        195                 200                 205             





Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys Ile 

    210                 215                 220                 





Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu Ile 

225                 230                 235                 240 





Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala Gln 

                245                 250                 255     





Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu Lys 

            260                 265                 270         





Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu Asp 

        275                 280                 285             





Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His Val 

    290                 295                 300                 





Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln Asn 

305                 310                 315                 320 





Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu Gln 

                325                 330                 335     





Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu Leu 

            340                 345                 350         





Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met Val 

        355                 360                 365             





Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp Glu 

    370                 375                 380                 





Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val Lys 

385                 390                 395                 400 





Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu Leu 

                405                 410                 415     





Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser Ala 

            420                 425                 430         





Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser Met 

        435                 440                 445             





Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys Ala 

    450                 455                 460                 





Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser Leu 

465                 470                 475                 480 





Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln His 

                485                 490                 495     





Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met Leu 

            500                 505                 510         





Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys Glu 

        515                 520                 525             





Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln Leu 

    530                 535                 540                 





Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu Gly 

545                 550                 555                 560 





Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu Ile 

                565                 570                 575     





Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys Pro 

            580                 585                 590         





Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu Leu 

        595                 600                 605             





Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp Ser 

    610                 615                 620                 





Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys His 

625                 630                 635                 640 





Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val Ser 

                645                 650                 655     





Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys Leu 

            660                 665                 670         





Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro Ser 

        675                 680                 685             





Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr Pro 

    690                 695                 700                 





Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys Gln 

705                 710                 715                 720 





Glu Ser Trp Lys 

                





<210>  22

<211>  709

<212>  PRT

<213>  Homo sapiens



<400>  22



Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 

1               5                   10                  15      





Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 

            20                  25                  30          





Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 

        35                  40                  45              





Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 

    50                  55                  60                  





Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Ile Arg Val Leu Leu 

65                  70                  75                  80  





Gln Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu 

                85                  90                  95      





Leu Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr 

            100                 105                 110         





Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu 

        115                 120                 125             





Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn 

    130                 135                 140                 





Gln Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn 

145                 150                 155                 160 





Lys Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met 

                165                 170                 175     





Glu Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly 

            180                 185                 190         





Lys Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys 

        195                 200                 205             





Ile Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu 

    210                 215                 220                 





Ile Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala 

225                 230                 235                 240 





Gln Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu 

                245                 250                 255     





Lys Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu 

            260                 265                 270         





Asp Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His 

        275                 280                 285             





Val Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln 

    290                 295                 300                 





Asn Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu 

305                 310                 315                 320 





Gln Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu 

                325                 330                 335     





Leu Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met 

            340                 345                 350         





Val Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp 

        355                 360                 365             





Glu Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val 

    370                 375                 380                 





Lys Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu 

385                 390                 395                 400 





Leu Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser 

                405                 410                 415     





Ala Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser 

            420                 425                 430         





Met Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys 

        435                 440                 445             





Ala Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser 

    450                 455                 460                 





Leu Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln 

465                 470                 475                 480 





His Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met 

                485                 490                 495     





Leu Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys 

            500                 505                 510         





Glu Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln 

        515                 520                 525             





Leu Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu 

    530                 535                 540                 





Gly Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu 

545                 550                 555                 560 





Ile Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys 

                565                 570                 575     





Pro Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu 

            580                 585                 590         





Leu Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp 

        595                 600                 605             





Ser Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys 

    610                 615                 620                 





His Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val 

625                 630                 635                 640 





Ser Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys 

                645                 650                 655     





Leu Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro 

            660                 665                 670         





Ser Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr 

        675                 680                 685             





Pro Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys 

    690                 695                 700                 





Gln Glu Ser Trp Lys 

705                 





<210>  23

<211>  725

<212>  PRT

<213>  Homo sapiens



<400>  23



Met Ser Phe Pro Lys Ala Pro Leu Lys Arg Phe Asn Asp Pro Ser Gly 

1               5                   10                  15      





Cys Ala Pro Ser Pro Gly Ala Tyr Asp Val Lys Thr Leu Glu Val Leu 

            20                  25                  30          





Lys Gly Pro Val Ser Phe Gln Lys Ser Gln Arg Phe Lys Gln Gln Lys 

        35                  40                  45              





Glu Ser Lys Gln Asn Leu Asn Val Asp Lys Asp Thr Thr Leu Pro Ala 

    50                  55                  60                  





Ser Ala Arg Lys Val Lys Ser Ser Glu Ser Lys Lys Glu Ser Gln Lys 

65                  70                  75                  80  





Asn Asp Lys Asp Leu Lys Ile Leu Glu Lys Glu Ile Arg Val Leu Leu 

                85                  90                  95      





Gln Glu Arg Gly Ala Gln Asp Arg Arg Ile Gln Asp Leu Glu Thr Glu 

            100                 105                 110         





Leu Glu Lys Met Glu Ala Arg Leu Asn Ala Ala Leu Arg Glu Lys Thr 

        115                 120                 125             





Ser Leu Ser Ala Asn Asn Ala Thr Leu Glu Lys Gln Leu Ile Glu Leu 

    130                 135                 140                 





Thr Arg Thr Asn Glu Leu Leu Lys Ser Lys Phe Ser Glu Asn Gly Asn 

145                 150                 155                 160 





Gln Lys Asn Leu Arg Ile Leu Ser Leu Glu Leu Met Lys Leu Arg Asn 

                165                 170                 175     





Lys Arg Glu Thr Lys Met Arg Gly Met Met Ala Lys Gln Glu Gly Met 

            180                 185                 190         





Glu Met Lys Leu Gln Val Thr Gln Arg Ser Leu Glu Glu Ser Gln Gly 

        195                 200                 205             





Lys Ile Ala Gln Leu Glu Gly Lys Leu Val Ser Ile Glu Lys Glu Lys 

    210                 215                 220                 





Ile Asp Glu Lys Ser Glu Thr Glu Lys Leu Leu Glu Tyr Ile Glu Glu 

225                 230                 235                 240 





Ile Ser Cys Ala Ser Asp Gln Val Glu Lys Tyr Lys Leu Asp Ile Ala 

                245                 250                 255     





Gln Leu Glu Glu Asn Leu Lys Glu Lys Asn Asp Glu Ile Leu Ser Leu 

            260                 265                 270         





Lys Gln Ser Leu Glu Glu Asn Ile Val Ile Leu Ser Lys Gln Val Glu 

        275                 280                 285             





Asp Leu Asn Val Lys Cys Gln Leu Leu Glu Lys Glu Lys Glu Asp His 

    290                 295                 300                 





Val Asn Arg Asn Arg Glu His Asn Glu Asn Leu Asn Ala Glu Met Gln 

305                 310                 315                 320 





Asn Leu Lys Gln Lys Phe Ile Leu Glu Gln Gln Glu Arg Glu Lys Leu 

                325                 330                 335     





Gln Gln Lys Glu Leu Gln Ile Asp Ser Leu Leu Gln Gln Glu Lys Glu 

            340                 345                 350         





Leu Ser Ser Ser Leu His Gln Lys Leu Cys Ser Phe Gln Glu Glu Met 

        355                 360                 365             





Val Lys Glu Lys Asn Leu Phe Glu Glu Glu Leu Lys Gln Thr Leu Asp 

    370                 375                 380                 





Glu Leu Asp Lys Leu Gln Gln Lys Glu Glu Gln Ala Glu Arg Leu Val 

385                 390                 395                 400 





Lys Gln Leu Glu Glu Glu Ala Lys Ser Arg Ala Glu Glu Leu Lys Leu 

                405                 410                 415     





Leu Glu Glu Lys Leu Lys Gly Lys Glu Ala Glu Leu Glu Lys Ser Ser 

            420                 425                 430         





Ala Ala His Thr Gln Ala Thr Leu Leu Leu Gln Glu Lys Tyr Asp Ser 

        435                 440                 445             





Met Val Gln Ser Leu Glu Asp Val Thr Ala Gln Phe Glu Ser Tyr Lys 

    450                 455                 460                 





Ala Leu Thr Ala Ser Glu Ile Glu Asp Leu Lys Leu Glu Asn Ser Ser 

465                 470                 475                 480 





Leu Gln Glu Lys Ala Ala Lys Ala Gly Lys Asn Ala Glu Asp Val Gln 

                485                 490                 495     





His Gln Ile Leu Ala Thr Glu Ser Ser Asn Gln Glu Tyr Val Arg Met 

            500                 505                 510         





Leu Leu Asp Leu Gln Thr Lys Ser Ala Leu Lys Glu Thr Glu Ile Lys 

        515                 520                 525             





Glu Ile Thr Val Ser Phe Leu Gln Lys Ile Thr Asp Leu Gln Asn Gln 

    530                 535                 540                 





Leu Lys Gln Gln Glu Glu Asp Phe Arg Lys Gln Leu Glu Asp Glu Glu 

545                 550                 555                 560 





Gly Arg Lys Ala Glu Lys Glu Asn Thr Thr Ala Glu Leu Thr Glu Glu 

                565                 570                 575     





Ile Asn Lys Trp Arg Leu Leu Tyr Glu Glu Leu Tyr Asn Lys Thr Lys 

            580                 585                 590         





Pro Phe Gln Leu Gln Leu Asp Ala Phe Glu Val Glu Lys Gln Ala Leu 

        595                 600                 605             





Leu Asn Glu His Gly Ala Ala Gln Glu Gln Leu Asn Lys Ile Arg Asp 

    610                 615                 620                 





Ser Tyr Ala Lys Leu Leu Gly His Gln Asn Leu Lys Gln Lys Ile Lys 

625                 630                 635                 640 





His Val Val Lys Leu Lys Asp Glu Asn Ser Gln Leu Lys Ser Glu Val 

                645                 650                 655     





Ser Lys Leu Arg Cys Gln Leu Ala Lys Lys Lys Gln Ser Glu Thr Lys 

            660                 665                 670         





Leu Gln Glu Glu Leu Asn Lys Val Leu Gly Ile Lys His Phe Asp Pro 

        675                 680                 685             





Ser Lys Ala Phe His His Glu Ser Lys Glu Asn Phe Ala Leu Lys Thr 

    690                 695                 700                 





Pro Leu Lys Glu Gly Asn Thr Asn Cys Tyr Arg Ala Pro Met Glu Cys 

705                 710                 715                 720 





Gln Glu Ser Trp Lys 

                725 





<210>  24

<211>  638

<212>  PRT

<213>  Homo sapiens



<400>  24



Met Thr Leu Leu Ile Arg Val Leu Leu Gln Glu Arg Gly Ala Gln Asp 

1               5                   10                  15      





Arg Arg Ile Gln Asp Leu Glu Thr Glu Leu Glu Lys Met Glu Ala Arg 

            20                  25                  30          





Leu Asn Ala Ala Leu Arg Glu Lys Thr Ser Leu Ser Ala Asn Asn Ala 

        35                  40                  45              





Thr Leu Glu Lys Gln Leu Ile Glu Leu Thr Arg Thr Asn Glu Leu Leu 

    50                  55                  60                  





Lys Ser Lys Phe Ser Glu Asn Gly Asn Gln Lys Asn Leu Arg Ile Leu 

65                  70                  75                  80  





Ser Leu Glu Leu Met Lys Leu Arg Asn Lys Arg Glu Thr Lys Met Arg 

                85                  90                  95      





Gly Met Met Ala Lys Gln Glu Gly Met Glu Met Lys Leu Gln Val Thr 

            100                 105                 110         





Gln Arg Ser Leu Glu Glu Ser Gln Gly Lys Ile Ala Gln Leu Glu Gly 

        115                 120                 125             





Lys Leu Val Ser Ile Glu Lys Glu Lys Ile Asp Glu Lys Ser Glu Thr 

    130                 135                 140                 





Glu Lys Leu Leu Glu Tyr Ile Glu Glu Ile Ser Cys Ala Ser Asp Gln 

145                 150                 155                 160 





Val Glu Lys Tyr Lys Leu Asp Ile Ala Gln Leu Glu Glu Asn Leu Lys 

                165                 170                 175     





Glu Lys Asn Asp Glu Ile Leu Ser Leu Lys Gln Ser Leu Glu Glu Asn 

            180                 185                 190         





Ile Val Ile Leu Ser Lys Gln Val Glu Asp Leu Asn Val Lys Cys Gln 

        195                 200                 205             





Leu Leu Glu Lys Glu Lys Glu Asp His Val Asn Arg Asn Arg Glu His 

    210                 215                 220                 





Asn Glu Asn Leu Asn Ala Glu Met Gln Asn Leu Lys Gln Lys Phe Ile 

225                 230                 235                 240 





Leu Glu Gln Gln Glu Arg Glu Lys Leu Gln Gln Lys Glu Leu Gln Ile 

                245                 250                 255     





Asp Ser Leu Leu Gln Gln Glu Lys Glu Leu Ser Ser Ser Leu His Gln 

            260                 265                 270         





Lys Leu Cys Ser Phe Gln Glu Glu Met Val Lys Glu Lys Asn Leu Phe 

        275                 280                 285             





Glu Glu Glu Leu Lys Gln Thr Leu Asp Glu Leu Asp Lys Leu Gln Gln 

    290                 295                 300                 





Lys Glu Glu Gln Ala Glu Arg Leu Val Lys Gln Leu Glu Glu Glu Ala 

305                 310                 315                 320 





Lys Ser Arg Ala Glu Glu Leu Lys Leu Leu Glu Glu Lys Leu Lys Gly 

                325                 330                 335     





Lys Glu Ala Glu Leu Glu Lys Ser Ser Ala Ala His Thr Gln Ala Thr 

            340                 345                 350         





Leu Leu Leu Gln Glu Lys Tyr Asp Ser Met Val Gln Ser Leu Glu Asp 

        355                 360                 365             





Val Thr Ala Gln Phe Glu Ser Tyr Lys Ala Leu Thr Ala Ser Glu Ile 

    370                 375                 380                 





Glu Asp Leu Lys Leu Glu Asn Ser Ser Leu Gln Glu Lys Ala Ala Lys 

385                 390                 395                 400 





Ala Gly Lys Asn Ala Glu Asp Val Gln His Gln Ile Leu Ala Thr Glu 

                405                 410                 415     





Ser Ser Asn Gln Glu Tyr Val Arg Met Leu Leu Asp Leu Gln Thr Lys 

            420                 425                 430         





Ser Ala Leu Lys Glu Thr Glu Ile Lys Glu Ile Thr Val Ser Phe Leu 

        435                 440                 445             





Gln Lys Ile Thr Asp Leu Gln Asn Gln Leu Lys Gln Gln Glu Glu Asp 

    450                 455                 460                 





Phe Arg Lys Gln Leu Glu Asp Glu Glu Gly Arg Lys Ala Glu Lys Glu 

465                 470                 475                 480 





Asn Thr Thr Ala Glu Leu Thr Glu Glu Ile Asn Lys Trp Arg Leu Leu 

                485                 490                 495     





Tyr Glu Glu Leu Tyr Asn Lys Thr Lys Pro Phe Gln Leu Gln Leu Asp 

            500                 505                 510         





Ala Phe Glu Val Glu Lys Gln Ala Leu Leu Asn Glu His Gly Ala Ala 

        515                 520                 525             





Gln Glu Gln Leu Asn Lys Ile Arg Asp Ser Tyr Ala Lys Leu Leu Gly 

    530                 535                 540                 





His Gln Asn Leu Lys Gln Lys Ile Lys His Val Val Lys Leu Lys Asp 

545                 550                 555                 560 





Glu Asn Ser Gln Leu Lys Ser Glu Val Ser Lys Leu Arg Cys Gln Leu 

                565                 570                 575     





Ala Lys Lys Lys Gln Ser Glu Thr Lys Leu Gln Glu Glu Leu Asn Lys 

            580                 585                 590         





Val Leu Gly Ile Lys His Phe Asp Pro Ser Lys Ala Phe His His Glu 

        595                 600                 605             





Ser Lys Glu Asn Phe Ala Leu Lys Thr Pro Leu Lys Glu Gly Asn Thr 

    610                 615                 620                 





Asn Cys Tyr Arg Ala Pro Met Glu Cys Gln Glu Ser Trp Lys 

625                 630                 635             





<210>  25

<211>  193

<212>  PRT

<213>  Homo sapiens



<400>  25



Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 

1               5                   10                  15      





Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 

            20                  25                  30          





Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 

        35                  40                  45              





Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 

    50                  55                  60                  





Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 

65                  70                  75                  80  





Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 

                85                  90                  95      





Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 

            100                 105                 110         





Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 

        115                 120                 125             





Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 

    130                 135                 140                 





His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 

145                 150                 155                 160 





Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 

                165                 170                 175     





Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 

            180                 185                 190         





Asp 

    





<210>  26

<211>  189

<212>  PRT

<213>  Homo sapiens



<400>  26



Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 

1               5                   10                  15      





Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Glu Asn Leu Glu Ser Asp 

            20                  25                  30          





Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 

        35                  40                  45              





Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 

    50                  55                  60                  





Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 

65                  70                  75                  80  





Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 

                85                  90                  95      





Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 

            100                 105                 110         





Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 

        115                 120                 125             





Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 

    130                 135                 140                 





Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 

145                 150                 155                 160 





Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 

                165                 170                 175     





Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 

            180                 185                 





<210>  27

<211>  177

<212>  PRT

<213>  Homo sapiens



<400>  27



Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 

1               5                   10                  15      





Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 

            20                  25                  30          





Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 

        35                  40                  45              





Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 

    50                  55                  60                  





Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 

65                  70                  75                  80  





Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 

                85                  90                  95      





Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 

            100                 105                 110         





Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 

        115                 120                 125             





Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 

    130                 135                 140                 





Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 

145                 150                 155                 160 





Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 

                165                 170                 175     





His 

    





<210>  28

<211>  133

<212>  PRT

<213>  Homo sapiens



<400>  28



Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 

1               5                   10                  15      





Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 

            20                  25                  30          





Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 

        35                  40                  45              





Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 

    50                  55                  60                  





Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 

65                  70                  75                  80  





Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 

                85                  90                  95      





Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 

            100                 105                 110         





Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 

        115                 120                 125             





Gly Thr Lys Glu His 

    130             





<210>  29

<211>  64

<212>  PRT

<213>  Homo sapiens



<400>  29



Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 

1               5                   10                  15      





Lys Arg His Ile Cys Asp Ala Asn Lys Glu Glu Asn Lys Ser Leu Lys 

            20                  25                  30          





Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln 

        35                  40                  45              





Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 

    50                  55                  60                  





<210>  30

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  30



Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 

1               5                   10                  15      





Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 

            20                  25                  30          





Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 

        35                  40                  45              





Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 

    50                  55                  60                  





Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 

65                  70                  75                  80  





Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 

                85                  90                  95      





Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 

            100                 105                 110         





Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 

        115                 120                 125             





Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 

    130                 135                 140                 





Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 

145                 150                 155                 160 





Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 

                165                 170                 175     





His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 

            180                 185                 190         





Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 

        195                 200                 205             





Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 

    210                 215                 220                 





Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 

225                 230                 235                 240 





Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 

                245                 250             





<210>  31

<211>  1306

<212>  PRT

<213>  Homo sapiens



<400>  31



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 

        35                  40                  45              





Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 

    50                  55                  60                  





Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 

65                  70                  75                  80  





Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 

                85                  90                  95      





Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 

            100                 105                 110         





Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 

        115                 120                 125             





Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 

    130                 135                 140                 





Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 

145                 150                 155                 160 





Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 

                165                 170                 175     





Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 

            180                 185                 190         





Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 

        195                 200                 205             





Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 

    210                 215                 220                 





Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 

225                 230                 235                 240 





Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 

                245                 250                 255     





Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 

            260                 265                 270         





Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 

        275                 280                 285             





Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 

    290                 295                 300                 





Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 

305                 310                 315                 320 





Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 

                325                 330                 335     





Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 

            340                 345                 350         





Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 

        355                 360                 365             





Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 

    370                 375                 380                 





Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 

385                 390                 395                 400 





Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 

                405                 410                 415     





Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 

            420                 425                 430         





Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 

        435                 440                 445             





Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 

    450                 455                 460                 





Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 

465                 470                 475                 480 





Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 

                485                 490                 495     





Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 

            500                 505                 510         





Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 

        515                 520                 525             





Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 

    530                 535                 540                 





Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 

545                 550                 555                 560 





Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 

                565                 570                 575     





Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 

            580                 585                 590         





Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 

        595                 600                 605             





Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 

    610                 615                 620                 





Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 

625                 630                 635                 640 





Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 

                645                 650                 655     





Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 

            660                 665                 670         





Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 

        675                 680                 685             





Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 

    690                 695                 700                 





Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 

705                 710                 715                 720 





Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 

                725                 730                 735     





Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 

            740                 745                 750         





Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 

        755                 760                 765             





Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 

    770                 775                 780                 





Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 

785                 790                 795                 800 





Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 

                805                 810                 815     





Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 

            820                 825                 830         





Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 

        835                 840                 845             





Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 

    850                 855                 860                 





Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 

865                 870                 875                 880 





Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 

                885                 890                 895     





Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 

            900                 905                 910         





Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 

        915                 920                 925             





Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 

    930                 935                 940                 





Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 

945                 950                 955                 960 





His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 

                965                 970                 975     





Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 

            980                 985                 990         





Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 

        995                 1000                 1005             





Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 

    1010                 1015                 1020             





Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 

    1025                 1030                 1035             





Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 

    1040                 1045                 1050             





Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 

    1055                 1060                 1065             





Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 

    1070                 1075                 1080             





Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 

    1085                 1090                 1095             





Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 

    1100                 1105                 1110             





Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 

    1115                 1120                 1125             





Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 

    1130                 1135                 1140             





Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 

    1145                 1150                 1155             





His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 

    1160                 1165                 1170             





Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 

    1175                 1180                 1185             





Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 

    1190                 1195                 1200             





Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 

    1205                 1210                 1215             





Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 

    1220                 1225                 1230             





Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 

    1235                 1240                 1245             





Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 

    1250                 1255                 1260             





Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 

    1265                 1270                 1275             





Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 

    1280                 1285                 1290             





Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 

    1295                 1300                 1305     





<210>  32

<211>  1145

<212>  PRT

<213>  Homo sapiens



<400>  32



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 

        35                  40                  45              





Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 

    50                  55                  60                  





Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 

65                  70                  75                  80  





Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 

                85                  90                  95      





Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 

            100                 105                 110         





Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 

        115                 120                 125             





Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 

    130                 135                 140                 





Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 

145                 150                 155                 160 





Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 

                165                 170                 175     





Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 

            180                 185                 190         





Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 

        195                 200                 205             





Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 

    210                 215                 220                 





Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 

225                 230                 235                 240 





Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 

                245                 250                 255     





Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 

            260                 265                 270         





Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 

        275                 280                 285             





Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 

    290                 295                 300                 





Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 

305                 310                 315                 320 





Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 

                325                 330                 335     





Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 

            340                 345                 350         





Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 

        355                 360                 365             





Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 

    370                 375                 380                 





Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 

385                 390                 395                 400 





Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 

                405                 410                 415     





Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 

            420                 425                 430         





Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 

        435                 440                 445             





Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 

    450                 455                 460                 





Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 

465                 470                 475                 480 





Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 

                485                 490                 495     





Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 

            500                 505                 510         





Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 

        515                 520                 525             





Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 

    530                 535                 540                 





Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 

545                 550                 555                 560 





Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 

                565                 570                 575     





Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 

            580                 585                 590         





Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 

        595                 600                 605             





Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 

    610                 615                 620                 





His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 

625                 630                 635                 640 





Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 

                645                 650                 655     





Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 

            660                 665                 670         





Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 

        675                 680                 685             





Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 

    690                 695                 700                 





Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 

705                 710                 715                 720 





Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 

                725                 730                 735     





Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 

            740                 745                 750         





Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 

        755                 760                 765             





His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 

    770                 775                 780                 





Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 

785                 790                 795                 800 





Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 

                805                 810                 815     





Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 

            820                 825                 830         





Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 

        835                 840                 845             





Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 

    850                 855                 860                 





Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 

865                 870                 875                 880 





Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 

                885                 890                 895     





Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 

            900                 905                 910         





Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 

        915                 920                 925             





Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 

    930                 935                 940                 





Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 

945                 950                 955                 960 





Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 

                965                 970                 975     





Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 

            980                 985                 990         





Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 

        995                 1000                 1005             





Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 

    1010                 1015                 1020             





Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 

    1025                 1030                 1035             





Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 

    1040                 1045                 1050             





Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 

    1055                 1060                 1065             





Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 

    1070                 1075                 1080             





Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 

    1085                 1090                 1095             





Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 

    1100                 1105                 1110             





Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 

    1115                 1120                 1125             





Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 

    1130                 1135                 1140             





Gly Ser  

    1145 





<210>  33

<211>  1258

<212>  PRT

<213>  Homo sapiens



<400>  33



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 

        35                  40                  45              





Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 

    50                  55                  60                  





Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 

65                  70                  75                  80  





Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 

                85                  90                  95      





Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 

            100                 105                 110         





Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 

        115                 120                 125             





Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 

    130                 135                 140                 





Ile Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 

145                 150                 155                 160 





Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 

                165                 170                 175     





Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 

            180                 185                 190         





Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 

        195                 200                 205             





Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 

    210                 215                 220                 





Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 

225                 230                 235                 240 





Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 

                245                 250                 255     





Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 

            260                 265                 270         





Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 

        275                 280                 285             





Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 

    290                 295                 300                 





Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 

305                 310                 315                 320 





Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 

                325                 330                 335     





Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 

            340                 345                 350         





Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 

        355                 360                 365             





Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 

    370                 375                 380                 





Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 

385                 390                 395                 400 





Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 

                405                 410                 415     





Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 

            420                 425                 430         





Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 

        435                 440                 445             





Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 

    450                 455                 460                 





Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 

465                 470                 475                 480 





Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 

                485                 490                 495     





Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 

            500                 505                 510         





Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 

        515                 520                 525             





Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 

    530                 535                 540                 





Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 

545                 550                 555                 560 





Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 

                565                 570                 575     





Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 

            580                 585                 590         





Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 

        595                 600                 605             





Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 

    610                 615                 620                 





Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 

625                 630                 635                 640 





Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 

                645                 650                 655     





Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 

            660                 665                 670         





Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 

        675                 680                 685             





Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 

    690                 695                 700                 





Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 

705                 710                 715                 720 





Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 

                725                 730                 735     





Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 

            740                 745                 750         





Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 

        755                 760                 765             





Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 

    770                 775                 780                 





Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 

785                 790                 795                 800 





Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 

                805                 810                 815     





Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 

            820                 825                 830         





Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 

        835                 840                 845             





Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 

    850                 855                 860                 





Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 

865                 870                 875                 880 





Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 

                885                 890                 895     





Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 

            900                 905                 910         





His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 

        915                 920                 925             





Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 

    930                 935                 940                 





Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 

945                 950                 955                 960 





Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 

                965                 970                 975     





Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 

            980                 985                 990         





Glu Thr Ile Gly Asp Phe Trp Gln  Met Ile Phe Gln Arg  Lys Val Lys 

        995                 1000                 1005             





Val Ile  Val Met Leu Thr Glu  Leu Lys His Gly Asp  Gln Glu Ile 

    1010                 1015                 1020             





Cys Ala  Gln Tyr Trp Gly Glu  Gly Lys Gln Thr Tyr  Gly Asp Ile 

    1025                 1030                 1035             





Glu Val  Asp Leu Lys Asp Thr  Asp Lys Ser Ser Thr  Tyr Thr Leu 

    1040                 1045                 1050             





Arg Val  Phe Glu Leu Arg His  Ser Lys Arg Lys Asp  Ser Arg Thr 

    1055                 1060                 1065             





Val Tyr  Gln Tyr Gln Tyr Thr  Asn Trp Ser Val Glu  Gln Leu Pro 

    1070                 1075                 1080             





Ala Glu  Pro Lys Glu Leu Ile  Ser Met Ile Gln Val  Val Lys Gln 

    1085                 1090                 1095             





Lys Leu  Pro Gln Lys Asn Ser  Ser Glu Gly Asn Lys  His His Lys 

    1100                 1105                 1110             





Ser Thr  Pro Leu Leu Ile His  Cys Arg Asp Gly Ser  Gln Gln Thr 

    1115                 1120                 1125             





Gly Ile  Phe Cys Ala Leu Leu  Asn Leu Leu Glu Ser  Ala Glu Thr 

    1130                 1135                 1140             





Glu Glu  Val Val Asp Ile Phe  Gln Val Val Lys Ala  Leu Arg Lys 

    1145                 1150                 1155             





Ala Arg  Pro Gly Met Val Ser  Thr Phe Glu Gln Tyr  Gln Phe Leu 

    1160                 1165                 1170             





Tyr Asp  Val Ile Ala Ser Thr  Tyr Pro Ala Gln Asn  Gly Gln Val 

    1175                 1180                 1185             





Lys Lys  Asn Asn His Gln Glu  Asp Lys Ile Glu Phe  Asp Asn Glu 

    1190                 1195                 1200             





Val Asp  Lys Val Lys Gln Asp  Ala Asn Cys Val Asn  Pro Leu Gly 

    1205                 1210                 1215             





Ala Pro  Glu Lys Leu Pro Glu  Ala Lys Glu Gln Ala  Glu Gly Ser 

    1220                 1225                 1230             





Glu Pro  Thr Ser Gly Thr Glu  Gly Pro Glu His Ser  Val Asn Gly 

    1235                 1240                 1245             





Pro Ala  Ser Pro Ala Leu Asn  Gln Gly Ser 

    1250                 1255             





<210>  34

<211>  1259

<212>  PRT

<213>  Homo sapiens



<400>  34



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 

        35                  40                  45              





Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 

    50                  55                  60                  





Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 

65                  70                  75                  80  





Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 

                85                  90                  95      





Asn Thr Thr Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro 

            100                 105                 110         





Thr Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His 

        115                 120                 125             





Ser Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala 

    130                 135                 140                 





Asn Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser 

145                 150                 155                 160 





Pro Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro 

                165                 170                 175     





Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr 

            180                 185                 190         





Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn 

        195                 200                 205             





Glu Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His 

    210                 215                 220                 





Asn Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser 

225                 230                 235                 240 





Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val 

                245                 250                 255     





Glu Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr 

            260                 265                 270         





Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr 

        275                 280                 285             





Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn 

    290                 295                 300                 





Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys 

305                 310                 315                 320 





Asp Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys 

                325                 330                 335     





Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe 

            340                 345                 350         





Cys Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro 

        355                 360                 365             





Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu 

    370                 375                 380                 





Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln 

385                 390                 395                 400 





Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile 

                405                 410                 415     





Ile Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr 

            420                 425                 430         





Thr Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met 

        435                 440                 445             





Thr Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg 

    450                 455                 460                 





Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr 

465                 470                 475                 480 





Leu Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp 

                485                 490                 495     





Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly 

            500                 505                 510         





Asp Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn 

        515                 520                 525             





Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser 

    530                 535                 540                 





Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys 

545                 550                 555                 560 





Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp 

                565                 570                 575     





Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu 

            580                 585                 590         





Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala 

        595                 600                 605             





Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu 

    610                 615                 620                 





Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu 

625                 630                 635                 640 





Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala 

                645                 650                 655     





Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro 

            660                 665                 670         





Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp 

        675                 680                 685             





Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val 

    690                 695                 700                 





Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro 

705                 710                 715                 720 





Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile 

                725                 730                 735     





Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile 

            740                 745                 750         





Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln 

        755                 760                 765             





Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu 

    770                 775                 780                 





Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly 

785                 790                 795                 800 





Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr 

                805                 810                 815     





Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val 

            820                 825                 830         





Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met 

        835                 840                 845             





Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu 

    850                 855                 860                 





Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro 

865                 870                 875                 880 





Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro 

                885                 890                 895     





Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr 

            900                 905                 910         





Gln His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser 

        915                 920                 925             





Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu 

    930                 935                 940                 





Glu Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp 

945                 950                 955                 960 





Asp Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile 

                965                 970                 975     





Met Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu 

            980                 985                 990         





Lys Glu Thr Ile Gly Asp Phe Trp  Gln Met Ile Phe Gln  Arg Lys Val 

        995                 1000                 1005             





Lys Val  Ile Val Met Leu Thr  Glu Leu Lys His Gly  Asp Gln Glu 

    1010                 1015                 1020             





Ile Cys  Ala Gln Tyr Trp Gly  Glu Gly Lys Gln Thr  Tyr Gly Asp 

    1025                 1030                 1035             





Ile Glu  Val Asp Leu Lys Asp  Thr Asp Lys Ser Ser  Thr Tyr Thr 

    1040                 1045                 1050             





Leu Arg  Val Phe Glu Leu Arg  His Ser Lys Arg Lys  Asp Ser Arg 

    1055                 1060                 1065             





Thr Val  Tyr Gln Tyr Gln Tyr  Thr Asn Trp Ser Val  Glu Gln Leu 

    1070                 1075                 1080             





Pro Ala  Glu Pro Lys Glu Leu  Ile Ser Met Ile Gln  Val Val Lys 

    1085                 1090                 1095             





Gln Lys  Leu Pro Gln Lys Asn  Ser Ser Glu Gly Asn  Lys His His 

    1100                 1105                 1110             





Lys Ser  Thr Pro Leu Leu Ile  His Cys Arg Asp Gly  Ser Gln Gln 

    1115                 1120                 1125             





Thr Gly  Ile Phe Cys Ala Leu  Leu Asn Leu Leu Glu  Ser Ala Glu 

    1130                 1135                 1140             





Thr Glu  Glu Val Val Asp Ile  Phe Gln Val Val Lys  Ala Leu Arg 

    1145                 1150                 1155             





Lys Ala  Arg Pro Gly Met Val  Ser Thr Phe Glu Gln  Tyr Gln Phe 

    1160                 1165                 1170             





Leu Tyr  Asp Val Ile Ala Ser  Thr Tyr Pro Ala Gln  Asn Gly Gln 

    1175                 1180                 1185             





Val Lys  Lys Asn Asn His Gln  Glu Asp Lys Ile Glu  Phe Asp Asn 

    1190                 1195                 1200             





Glu Val  Asp Lys Val Lys Gln  Asp Ala Asn Cys Val  Asn Pro Leu 

    1205                 1210                 1215             





Gly Ala  Pro Glu Lys Leu Pro  Glu Ala Lys Glu Gln  Ala Glu Gly 

    1220                 1225                 1230             





Ser Glu  Pro Thr Ser Gly Thr  Glu Gly Pro Glu His  Ser Val Asn 

    1235                 1240                 1245             





Gly Pro  Ala Ser Pro Ala Leu  Asn Gln Gly Ser 

    1250                 1255                 





<210>  35

<211>  1240

<212>  PRT

<213>  Homo sapiens



<400>  35



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 

        35                  40                  45              





Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 

    50                  55                  60                  





Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 

65                  70                  75                  80  





Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 

                85                  90                  95      





Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 

            100                 105                 110         





Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 

        115                 120                 125             





Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 

    130                 135                 140                 





Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 

145                 150                 155                 160 





Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 

                165                 170                 175     





Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 

            180                 185                 190         





Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 

        195                 200                 205             





Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 

    210                 215                 220                 





Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 

225                 230                 235                 240 





Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 

                245                 250                 255     





Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 

            260                 265                 270         





Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 

        275                 280                 285             





Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 

    290                 295                 300                 





Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 

305                 310                 315                 320 





Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 

                325                 330                 335     





Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 

            340                 345                 350         





Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 

        355                 360                 365             





Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 

    370                 375                 380                 





Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 

385                 390                 395                 400 





Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 

                405                 410                 415     





Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 

            420                 425                 430         





Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 

        435                 440                 445             





His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 

    450                 455                 460                 





Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 

465                 470                 475                 480 





Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 

                485                 490                 495     





Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 

            500                 505                 510         





Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 

        515                 520                 525             





Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 

    530                 535                 540                 





Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 

545                 550                 555                 560 





Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 

                565                 570                 575     





Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 

            580                 585                 590         





Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 

        595                 600                 605             





Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 

    610                 615                 620                 





Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 

625                 630                 635                 640 





Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 

                645                 650                 655     





Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 

            660                 665                 670         





Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 

        675                 680                 685             





Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 

    690                 695                 700                 





Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 

705                 710                 715                 720 





Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 

                725                 730                 735     





Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 

            740                 745                 750         





Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 

        755                 760                 765             





Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 

    770                 775                 780                 





Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 

785                 790                 795                 800 





Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 

                805                 810                 815     





Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 

            820                 825                 830         





Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 

        835                 840                 845             





Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 

    850                 855                 860                 





Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 

865                 870                 875                 880 





Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 

                885                 890                 895     





Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 

            900                 905                 910         





Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 

        915                 920                 925             





Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 

    930                 935                 940                 





Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 

945                 950                 955                 960 





Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 

                965                 970                 975     





Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 

            980                 985                 990         





Val Met Leu Thr Glu Leu Lys His  Gly Asp Gln Glu Ile  Cys Ala Gln 

        995                 1000                 1005             





Tyr Trp  Gly Glu Gly Lys Gln  Thr Tyr Gly Asp Ile  Glu Val Asp 

    1010                 1015                 1020             





Leu Lys  Asp Thr Asp Lys Ser  Ser Thr Tyr Thr Leu  Arg Val Phe 

    1025                 1030                 1035             





Glu Leu  Arg His Ser Lys Arg  Lys Asp Ser Arg Thr  Val Tyr Gln 

    1040                 1045                 1050             





Tyr Gln  Tyr Thr Asn Trp Ser  Val Glu Gln Leu Pro  Ala Glu Pro 

    1055                 1060                 1065             





Lys Glu  Leu Ile Ser Met Ile  Gln Val Val Lys Gln  Lys Leu Pro 

    1070                 1075                 1080             





Gln Lys  Asn Ser Ser Glu Gly  Asn Lys His His Lys  Ser Thr Pro 

    1085                 1090                 1095             





Leu Leu  Ile His Cys Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe 

    1100                 1105                 1110             





Cys Ala  Leu Leu Asn Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val 

    1115                 1120                 1125             





Val Asp  Ile Phe Gln Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro 

    1130                 1135                 1140             





Gly Met  Val Ser Thr Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val 

    1145                 1150                 1155             





Ile Ala  Ser Thr Tyr Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn 

    1160                 1165                 1170             





Asn His  Gln Glu Asp Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys 

    1175                 1180                 1185             





Val Lys  Gln Asp Ala Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu 

    1190                 1195                 1200             





Lys Leu  Pro Glu Ala Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr 

    1205                 1210                 1215             





Ser Gly  Thr Glu Gly Pro Glu  His Ser Val Asn Gly  Pro Ala Ser 

    1220                 1225                 1230             





Pro Ala  Leu Asn Gln Gly Ser  

    1235                 1240 





<210>  36

<211>  1211

<212>  PRT

<213>  Homo sapiens



<400>  36



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 

        35                  40                  45              





Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 

    50                  55                  60                  





Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 

65                  70                  75                  80  





Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 

                85                  90                  95      





Asn Thr Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser 

            100                 105                 110         





Pro Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro 

        115                 120                 125             





Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr 

    130                 135                 140                 





Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn 

145                 150                 155                 160 





Glu Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His 

                165                 170                 175     





Asn Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser 

            180                 185                 190         





Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val 

        195                 200                 205             





Glu Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr 

    210                 215                 220                 





Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr 

225                 230                 235                 240 





Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn 

                245                 250                 255     





Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys 

            260                 265                 270         





Asp Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys 

        275                 280                 285             





Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe 

    290                 295                 300                 





Cys Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro 

305                 310                 315                 320 





Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu 

                325                 330                 335     





Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln 

            340                 345                 350         





Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile 

        355                 360                 365             





Ile Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr 

    370                 375                 380                 





Thr Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met 

385                 390                 395                 400 





Thr Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg 

                405                 410                 415     





Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr 

            420                 425                 430         





Leu Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp 

        435                 440                 445             





Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly 

    450                 455                 460                 





Asp Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn 

465                 470                 475                 480 





Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser 

                485                 490                 495     





Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys 

            500                 505                 510         





Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp 

        515                 520                 525             





Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu 

    530                 535                 540                 





Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala 

545                 550                 555                 560 





Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu 

                565                 570                 575     





Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu 

            580                 585                 590         





Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala 

        595                 600                 605             





Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro 

    610                 615                 620                 





Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp 

625                 630                 635                 640 





Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val 

                645                 650                 655     





Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro 

            660                 665                 670         





Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile 

        675                 680                 685             





Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile 

    690                 695                 700                 





Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln 

705                 710                 715                 720 





Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu 

                725                 730                 735     





Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly 

            740                 745                 750         





Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr 

        755                 760                 765             





Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val 

    770                 775                 780                 





Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met 

785                 790                 795                 800 





Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu 

                805                 810                 815     





Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro 

            820                 825                 830         





Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro 

        835                 840                 845             





Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr 

    850                 855                 860                 





Gln His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser 

865                 870                 875                 880 





Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu 

                885                 890                 895     





Glu Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp 

            900                 905                 910         





Asp Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile 

        915                 920                 925             





Met Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu 

    930                 935                 940                 





Lys Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val 

945                 950                 955                 960 





Lys Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile 

                965                 970                 975     





Cys Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu 

            980                 985                 990         





Val Asp Leu Lys Asp Thr Asp Lys  Ser Ser Thr Tyr Thr  Leu Arg Val 

        995                 1000                 1005             





Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp Ser Arg  Thr Val Tyr 

    1010                 1015                 1020             





Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu Gln Leu  Pro Ala Glu 

    1025                 1030                 1035             





Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val Val Lys  Gln Lys Leu 

    1040                 1045                 1050             





Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys His His  Lys Ser Thr 

    1055                 1060                 1065             





Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser Gln Gln  Thr Gly Ile 

    1070                 1075                 1080             





Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser Ala Glu  Thr Glu Glu 

    1085                 1090                 1095             





Val Val  Asp Ile Phe Gln Val  Val Lys Ala Leu Arg  Lys Ala Arg 

    1100                 1105                 1110             





Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr Gln Phe  Leu Tyr Asp 

    1115                 1120                 1125             





Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn Gly Gln  Val Lys Lys 

    1130                 1135                 1140             





Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe Asp Asn  Glu Val Asp 

    1145                 1150                 1155             





Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn Pro Leu  Gly Ala Pro 

    1160                 1165                 1170             





Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala Glu Gly  Ser Glu Pro 

    1175                 1180                 1185             





Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser Val Asn  Gly Pro Ala 

    1190                 1195                 1200             





Ser Pro  Ala Leu Asn Gln Gly  Ser 

    1205                 1210     





<210>  37

<211>  1192

<212>  PRT

<213>  Homo sapiens



<400>  37



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 

        35                  40                  45              





Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 

    50                  55                  60                  





Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 

65                  70                  75                  80  





Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 

                85                  90                  95      





Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 

            100                 105                 110         





Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 

        115                 120                 125             





Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 

    130                 135                 140                 





Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 

145                 150                 155                 160 





Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 

                165                 170                 175     





Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 

            180                 185                 190         





Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 

        195                 200                 205             





Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 

    210                 215                 220                 





Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 

225                 230                 235                 240 





Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 

                245                 250                 255     





Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 

            260                 265                 270         





Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 

        275                 280                 285             





Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 

    290                 295                 300                 





Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 

305                 310                 315                 320 





Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 

                325                 330                 335     





Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 

            340                 345                 350         





Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 

        355                 360                 365             





Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 

    370                 375                 380                 





Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 

385                 390                 395                 400 





His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 

                405                 410                 415     





Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 

            420                 425                 430         





Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 

        435                 440                 445             





Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 

    450                 455                 460                 





Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 

465                 470                 475                 480 





Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 

                485                 490                 495     





Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 

            500                 505                 510         





Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 

        515                 520                 525             





Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 

    530                 535                 540                 





Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 

545                 550                 555                 560 





Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 

                565                 570                 575     





Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 

            580                 585                 590         





Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 

        595                 600                 605             





Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 

    610                 615                 620                 





Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 

625                 630                 635                 640 





Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 

                645                 650                 655     





Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 

            660                 665                 670         





Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 

        675                 680                 685             





Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 

    690                 695                 700                 





Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 

705                 710                 715                 720 





Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 

                725                 730                 735     





Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 

            740                 745                 750         





Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 

        755                 760                 765             





Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 

    770                 775                 780                 





Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 

785                 790                 795                 800 





Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 

                805                 810                 815     





Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 

            820                 825                 830         





Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 

        835                 840                 845             





Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 

    850                 855                 860                 





Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 

865                 870                 875                 880 





Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 

                885                 890                 895     





Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 

            900                 905                 910         





Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 

        915                 920                 925             





Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 

    930                 935                 940                 





Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln 

945                 950                 955                 960 





Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu 

                965                 970                 975     





Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu 

            980                 985                 990         





Arg His Ser Lys Arg Lys Asp Ser  Arg Thr Val Tyr Gln  Tyr Gln Tyr 

        995                 1000                 1005             





Thr Asn  Trp Ser Val Glu Gln  Leu Pro Ala Glu Pro  Lys Glu Leu 

    1010                 1015                 1020             





Ile Ser  Met Ile Gln Val Val  Lys Gln Lys Leu Pro  Gln Lys Asn 

    1025                 1030                 1035             





Ser Ser  Glu Gly Asn Lys His  His Lys Ser Thr Pro  Leu Leu Ile 

    1040                 1045                 1050             





His Cys  Arg Asp Gly Ser Gln  Gln Thr Gly Ile Phe  Cys Ala Leu 

    1055                 1060                 1065             





Leu Asn  Leu Leu Glu Ser Ala  Glu Thr Glu Glu Val  Val Asp Ile 

    1070                 1075                 1080             





Phe Gln  Val Val Lys Ala Leu  Arg Lys Ala Arg Pro  Gly Met Val 

    1085                 1090                 1095             





Ser Thr  Phe Glu Gln Tyr Gln  Phe Leu Tyr Asp Val  Ile Ala Ser 

    1100                 1105                 1110             





Thr Tyr  Pro Ala Gln Asn Gly  Gln Val Lys Lys Asn  Asn His Gln 

    1115                 1120                 1125             





Glu Asp  Lys Ile Glu Phe Asp  Asn Glu Val Asp Lys  Val Lys Gln 

    1130                 1135                 1140             





Asp Ala  Asn Cys Val Asn Pro  Leu Gly Ala Pro Glu  Lys Leu Pro 

    1145                 1150                 1155             





Glu Ala  Lys Glu Gln Ala Glu  Gly Ser Glu Pro Thr  Ser Gly Thr 

    1160                 1165                 1170             





Glu Gly  Pro Glu His Ser Val  Asn Gly Pro Ala Ser  Pro Ala Leu 

    1175                 1180                 1185             





Asn Gln  Gly Ser 

    1190         





<210>  38

<211>  1193

<212>  PRT

<213>  Homo sapiens



<400>  38



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp 

        35                  40                  45              





Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser 

    50                  55                  60                  





Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr 

65                  70                  75                  80  





Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 

                85                  90                  95      





Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 

            100                 105                 110         





Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 

        115                 120                 125             





Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 

    130                 135                 140                 





Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 

145                 150                 155                 160 





Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 

                165                 170                 175     





Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 

            180                 185                 190         





Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 

        195                 200                 205             





Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 

    210                 215                 220                 





Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 

225                 230                 235                 240 





Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 

                245                 250                 255     





Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 

            260                 265                 270         





Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 

        275                 280                 285             





Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 

    290                 295                 300                 





Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 

305                 310                 315                 320 





Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 

                325                 330                 335     





Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 

            340                 345                 350         





Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 

        355                 360                 365             





Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 

    370                 375                 380                 





Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 

385                 390                 395                 400 





Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 

                405                 410                 415     





Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 

            420                 425                 430         





Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 

        435                 440                 445             





Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 

    450                 455                 460                 





Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 

465                 470                 475                 480 





Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 

                485                 490                 495     





Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 

            500                 505                 510         





Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 

        515                 520                 525             





Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 

    530                 535                 540                 





Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 

545                 550                 555                 560 





Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 

                565                 570                 575     





Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 

            580                 585                 590         





Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 

        595                 600                 605             





Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 

    610                 615                 620                 





Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 

625                 630                 635                 640 





Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 

                645                 650                 655     





Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 

            660                 665                 670         





His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 

        675                 680                 685             





Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 

    690                 695                 700                 





Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 

705                 710                 715                 720 





Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 

                725                 730                 735     





Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 

            740                 745                 750         





Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 

        755                 760                 765             





Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 

    770                 775                 780                 





Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 

785                 790                 795                 800 





Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 

                805                 810                 815     





His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 

            820                 825                 830         





Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 

        835                 840                 845             





Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 

    850                 855                 860                 





Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 

865                 870                 875                 880 





Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 

                885                 890                 895     





Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 

            900                 905                 910         





Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 

        915                 920                 925             





Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 

    930                 935                 940                 





Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 

945                 950                 955                 960 





Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 

                965                 970                 975     





Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 

            980                 985                 990         





Leu Arg His Ser Lys Arg Lys Asp  Ser Arg Thr Val Tyr  Gln Tyr Gln 

        995                 1000                 1005             





Tyr Thr  Asn Trp Ser Val Glu  Gln Leu Pro Ala Glu  Pro Lys Glu 

    1010                 1015                 1020             





Leu Ile  Ser Met Ile Gln Val  Val Lys Gln Lys Leu  Pro Gln Lys 

    1025                 1030                 1035             





Asn Ser  Ser Glu Gly Asn Lys  His His Lys Ser Thr  Pro Leu Leu 

    1040                 1045                 1050             





Ile His  Cys Arg Asp Gly Ser  Gln Gln Thr Gly Ile  Phe Cys Ala 

    1055                 1060                 1065             





Leu Leu  Asn Leu Leu Glu Ser  Ala Glu Thr Glu Glu  Val Val Asp 

    1070                 1075                 1080             





Ile Phe  Gln Val Val Lys Ala  Leu Arg Lys Ala Arg  Pro Gly Met 

    1085                 1090                 1095             





Val Ser  Thr Phe Glu Gln Tyr  Gln Phe Leu Tyr Asp  Val Ile Ala 

    1100                 1105                 1110             





Ser Thr  Tyr Pro Ala Gln Asn  Gly Gln Val Lys Lys  Asn Asn His 

    1115                 1120                 1125             





Gln Glu  Asp Lys Ile Glu Phe  Asp Asn Glu Val Asp  Lys Val Lys 

    1130                 1135                 1140             





Gln Asp  Ala Asn Cys Val Asn  Pro Leu Gly Ala Pro  Glu Lys Leu 

    1145                 1150                 1155             





Pro Glu  Ala Lys Glu Gln Ala  Glu Gly Ser Glu Pro  Thr Ser Gly 

    1160                 1165                 1170             





Thr Glu  Gly Pro Glu His Ser  Val Asn Gly Pro Ala  Ser Pro Ala 

    1175                 1180                 1185             





Leu Asn  Gln Gly Ser 

    1190             





<210>  39

<211>  412

<212>  PRT

<213>  Homo sapiens



<400>  39



Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 

1               5                   10                  15      





Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 

            20                  25                  30          





Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 

        35                  40                  45              





Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 

    50                  55                  60                  





Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 

65                  70                  75                  80  





Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 

                85                  90                  95      





Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 

            100                 105                 110         





Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 

        115                 120                 125             





Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 

    130                 135                 140                 





Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 

145                 150                 155                 160 





Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 

                165                 170                 175     





Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 

            180                 185                 190         





Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 

        195                 200                 205             





Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 

    210                 215                 220                 





Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 

225                 230                 235                 240 





Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 

                245                 250                 255     





Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 

            260                 265                 270         





Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 

        275                 280                 285             





Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 

    290                 295                 300                 





Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 

305                 310                 315                 320 





Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 

                325                 330                 335     





Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 

            340                 345                 350         





Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 

        355                 360                 365             





Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 

    370                 375                 380                 





Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 

385                 390                 395                 400 





Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 

                405                 410         





<210>  40

<211>  428

<212>  PRT

<213>  Homo sapiens



<400>  40



Met Ala Val Gly Ala Ser Gly Leu Glu Gly Asp Lys Met Ala Gly Ala 

1               5                   10                  15      





Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 

            20                  25                  30          





Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 

        35                  40                  45              





Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 

    50                  55                  60                  





Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 

65                  70                  75                  80  





Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 

                85                  90                  95      





Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 

            100                 105                 110         





Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 

        115                 120                 125             





Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 

    130                 135                 140                 





Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 

145                 150                 155                 160 





Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 

                165                 170                 175     





Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 

            180                 185                 190         





Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 

        195                 200                 205             





Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 

    210                 215                 220                 





Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 

225                 230                 235                 240 





Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 

                245                 250                 255     





Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 

            260                 265                 270         





Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 

        275                 280                 285             





Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 

    290                 295                 300                 





Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 

305                 310                 315                 320 





Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 

                325                 330                 335     





Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 

            340                 345                 350         





Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 

        355                 360                 365             





Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 

    370                 375                 380                 





Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 

385                 390                 395                 400 





Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 

                405                 410                 415     





Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 

            420                 425             





<210>  41

<211>  240

<212>  PRT

<213>  Homo sapiens



<400>  41



Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 

1               5                   10                  15      





Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 

            20                  25                  30          





Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 

        35                  40                  45              





Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 

    50                  55                  60                  





Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 

65                  70                  75                  80  





Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 

                85                  90                  95      





His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 

            100                 105                 110         





Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 

        115                 120                 125             





His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 

    130                 135                 140                 





Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 

145                 150                 155                 160 





Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 

                165                 170                 175     





Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 

            180                 185                 190         





Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 

        195                 200                 205             





Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 

    210                 215                 220                 





Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 

225                 230                 235                 240 





<210>  42

<211>  204

<212>  PRT

<213>  Homo sapiens



<400>  42



Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 

1               5                   10                  15      





Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 

            20                  25                  30          





Cys Ser Val Ala Arg Asp Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile 

        35                  40                  45              





Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly 

    50                  55                  60                  





Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr 

65                  70                  75                  80  





Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala 

                85                  90                  95      





Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln 

            100                 105                 110         





Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His 

        115                 120                 125             





Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu 

    130                 135                 140                 





Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val 

145                 150                 155                 160 





Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 

                165                 170                 175     





Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg 

            180                 185                 190         





Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 

        195                 200                 





<210>  43

<211>  1531

<212>  PRT

<213>  Homo sapiens



<400>  43



Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 

1               5                   10                  15      





Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 

            20                  25                  30          





Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 

        35                  40                  45              





Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 

    50                  55                  60                  





Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 

65                  70                  75                  80  





Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 

                85                  90                  95      





Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 

            100                 105                 110         





Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 

        115                 120                 125             





Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 

    130                 135                 140                 





Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 

145                 150                 155                 160 





Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 

                165                 170                 175     





Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 

            180                 185                 190         





Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 

        195                 200                 205             





Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 

    210                 215                 220                 





Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 

225                 230                 235                 240 





Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 

                245                 250                 255     





Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 

            260                 265                 270         





Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 

        275                 280                 285             





Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 

    290                 295                 300                 





Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 

305                 310                 315                 320 





Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 

                325                 330                 335     





Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 

            340                 345                 350         





Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile 

        355                 360                 365             





Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 

    370                 375                 380                 





Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys 

385                 390                 395                 400 





Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys 

                405                 410                 415     





Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys His 

            420                 425                 430         





Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly 

        435                 440                 445             





Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser 

    450                 455                 460                 





Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp Lys 

465                 470                 475                 480 





Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala 

                485                 490                 495     





Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys 

            500                 505                 510         





Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu 

        515                 520                 525             





Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln 

    530                 535                 540                 





Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn 

545                 550                 555                 560 





Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr Pro 

                565                 570                 575     





Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu 

            580                 585                 590         





Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys Trp 

        595                 600                 605             





Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala 

    610                 615                 620                 





Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys Tyr 

625                 630                 635                 640 





Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys 

                645                 650                 655     





Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg 

            660                 665                 670         





Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln 

        675                 680                 685             





Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile 

    690                 695                 700                 





Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val Asp 

705                 710                 715                 720 





Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg 

                725                 730                 735     





Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala 

            740                 745                 750         





Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr Ile 

        755                 760                 765             





Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu Leu 

    770                 775                 780                 





Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ser 

785                 790                 795                 800 





Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg Leu 

                805                 810                 815     





Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp Asp 

            820                 825                 830         





Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val 

        835                 840                 845             





Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile 

    850                 855                 860                 





Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu Met 

865                 870                 875                 880 





Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys 

                885                 890                 895     





Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu 

            900                 905                 910         





Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro Val 

        915                 920                 925             





Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met Leu 

    930                 935                 940                 





Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr 

945                 950                 955                 960 





His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys 

                965                 970                 975     





Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu Gln 

            980                 985                 990         





Thr Ser Leu Thr Cys Asn Ser Met  Val Leu Phe Asp His  Val Gly Cys 

        995                 1000                 1005             





Leu Lys  Lys Tyr Asp Thr Val  Leu Asp Ile Leu Arg  Asp Phe Phe 

    1010                 1015                 1020             





Glu Leu  Arg Leu Lys Tyr Tyr  Gly Leu Arg Lys Glu  Trp Leu Leu 

    1025                 1030                 1035             





Gly Met  Leu Gly Ala Glu Ser  Ala Lys Leu Asn Asn  Gln Ala Arg 

    1040                 1045                 1050             





Phe Ile  Leu Glu Lys Ile Asp  Gly Lys Ile Ile Ile  Glu Asn Lys 

    1055                 1060                 1065             





Pro Lys  Lys Glu Leu Ile Lys  Val Leu Ile Gln Arg  Gly Tyr Asp 

    1070                 1075                 1080             





Ser Asp  Pro Val Lys Ala Trp  Lys Glu Ala Gln Gln  Lys Val Pro 

    1085                 1090                 1095             





Asp Glu  Glu Glu Asn Glu Glu  Ser Asp Asn Glu Lys  Glu Thr Glu 

    1100                 1105                 1110             





Lys Ser  Asp Ser Val Thr Asp  Ser Gly Pro Thr Phe  Asn Tyr Leu 

    1115                 1120                 1125             





Leu Asp  Met Pro Leu Trp Tyr  Leu Thr Lys Glu Lys  Lys Asp Glu 

    1130                 1135                 1140             





Leu Cys  Arg Leu Arg Asn Glu  Lys Glu Gln Glu Leu  Asp Thr Leu 

    1145                 1150                 1155             





Lys Arg  Lys Ser Pro Ser Asp  Leu Trp Lys Glu Asp  Leu Ala Thr 

    1160                 1165                 1170             





Phe Ile  Glu Glu Leu Glu Ala  Val Glu Ala Lys Glu  Lys Gln Asp 

    1175                 1180                 1185             





Glu Gln  Val Gly Leu Pro Gly  Lys Gly Gly Lys Ala  Lys Gly Lys 

    1190                 1195                 1200             





Lys Thr  Gln Met Ala Glu Val  Leu Pro Ser Pro Arg  Gly Gln Arg 

    1205                 1210                 1215             





Val Ile  Pro Arg Ile Thr Ile  Glu Met Lys Ala Glu  Ala Glu Lys 

    1220                 1225                 1230             





Lys Asn  Lys Lys Lys Ile Lys  Asn Glu Asn Thr Glu  Gly Ser Pro 

    1235                 1240                 1245             





Gln Glu  Asp Gly Val Glu Leu  Glu Gly Leu Lys Gln  Arg Leu Glu 

    1250                 1255                 1260             





Lys Lys  Gln Lys Arg Glu Pro  Gly Thr Lys Thr Lys  Lys Gln Thr 

    1265                 1270                 1275             





Thr Leu  Ala Phe Lys Pro Ile  Lys Lys Gly Lys Lys  Arg Asn Pro 

    1280                 1285                 1290             





Trp Ser  Asp Ser Glu Ser Asp  Arg Ser Ser Asp Glu  Ser Asn Phe 

    1295                 1300                 1305             





Asp Val  Pro Pro Arg Glu Thr  Glu Pro Arg Arg Ala  Ala Thr Lys 

    1310                 1315                 1320             





Thr Lys  Phe Thr Met Asp Leu  Asp Ser Asp Glu Asp  Phe Ser Asp 

    1325                 1330                 1335             





Phe Asp  Glu Lys Thr Asp Asp  Glu Asp Phe Val Pro  Ser Asp Ala 

    1340                 1345                 1350             





Ser Pro  Pro Lys Thr Lys Thr  Ser Pro Lys Leu Ser  Asn Lys Glu 

    1355                 1360                 1365             





Leu Lys  Pro Gln Lys Ser Val  Val Ser Asp Leu Glu  Ala Asp Asp 

    1370                 1375                 1380             





Val Lys  Gly Ser Val Pro Leu  Ser Ser Ser Pro Pro  Ala Thr His 

    1385                 1390                 1395             





Phe Pro  Asp Glu Thr Glu Ile  Thr Asn Pro Val Pro  Lys Lys Asn 

    1400                 1405                 1410             





Val Thr  Val Lys Lys Thr Ala  Ala Lys Ser Gln Ser  Ser Thr Ser 

    1415                 1420                 1425             





Thr Thr  Gly Ala Lys Lys Arg  Ala Ala Pro Lys Gly  Thr Lys Arg 

    1430                 1435                 1440             





Asp Pro  Ala Leu Asn Ser Gly  Val Ser Gln Lys Pro  Asp Pro Ala 

    1445                 1450                 1455             





Lys Thr  Lys Asn Arg Arg Lys  Arg Lys Pro Ser Thr  Ser Asp Asp 

    1460                 1465                 1470             





Ser Asp  Ser Asn Phe Glu Lys  Ile Val Ser Lys Ala  Val Thr Ser 

    1475                 1480                 1485             





Lys Lys  Ser Lys Gly Glu Ser  Asp Asp Phe His Met  Asp Phe Asp 

    1490                 1495                 1500             





Ser Ala  Val Ala Pro Arg Ala  Lys Ser Val Arg Ala  Lys Lys Pro 

    1505                 1510                 1515             





Ile Lys  Tyr Leu Glu Glu Ser  Asp Glu Asp Asp Leu  Phe 

    1520                 1525                 1530     





<210>  44

<211>  1557

<212>  PRT

<213>  Homo sapiens



<400>  44



Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 

1               5                   10                  15      





Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 

            20                  25                  30          





Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 

        35                  40                  45              





Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 

    50                  55                  60                  





Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 

65                  70                  75                  80  





Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 

                85                  90                  95      





Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 

            100                 105                 110         





Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 

        115                 120                 125             





Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 

    130                 135                 140                 





Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 

145                 150                 155                 160 





Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 

                165                 170                 175     





Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 

            180                 185                 190         





Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 

        195                 200                 205             





Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 

    210                 215                 220                 





Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 

225                 230                 235                 240 





Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 

                245                 250                 255     





Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 

            260                 265                 270         





Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 

        275                 280                 285             





Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 

    290                 295                 300                 





Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 

305                 310                 315                 320 





Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 

                325                 330                 335     





Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 

            340                 345                 350         





Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile 

        355                 360                 365             





Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 

    370                 375                 380                 





Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys 

385                 390                 395                 400 





Ala His Leu Tyr Ser Arg Phe Leu Ile Asp Pro Phe Phe Pro Asn Met 

                405                 410                 415     





Ile Pro Asn Met Ile Phe Ser Phe Ser Lys Ala Ala Ile Gly Cys Gly 

            420                 425                 430         





Ile Val Glu Ser Ile Leu Asn Trp Val Lys Phe Lys Ala Gln Val Gln 

        435                 440                 445             





Leu Asn Lys Lys Cys Ser Ala Val Lys His Asn Arg Ile Lys Gly Ile 

    450                 455                 460                 





Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly Gly Arg Asn Ser Thr Glu 

465                 470                 475                 480 





Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser Ala Lys Thr Leu Ala Val 

                485                 490                 495     





Ser Gly Leu Gly Val Val Gly Arg Asp Lys Tyr Gly Val Phe Pro Leu 

            500                 505                 510         





Arg Gly Lys Ile Leu Asn Val Arg Glu Ala Ser His Lys Gln Ile Met 

        515                 520                 525             





Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr 

    530                 535                 540                 





Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu Lys Thr Leu Arg Tyr Gly 

545                 550                 555                 560 





Lys Ile Met Ile Met Thr Asp Gln Asp Gln Asp Gly Ser His Ile Lys 

                565                 570                 575     





Gly Leu Leu Ile Asn Phe Ile His His Asn Trp Pro Ser Leu Leu Arg 

            580                 585                 590         





His Arg Phe Leu Glu Glu Phe Ile Thr Pro Ile Val Lys Val Ser Lys 

        595                 600                 605             





Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu Pro Glu Phe Glu Glu Trp 

    610                 615                 620                 





Lys Ser Ser Thr Pro Asn His Lys Lys Trp Lys Val Lys Tyr Tyr Lys 

625                 630                 635                 640 





Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala Lys Glu Tyr Phe Ala Asp 

                645                 650                 655     





Met Lys Arg His Arg Ile Gln Phe Lys Tyr Ser Gly Pro Glu Asp Asp 

            660                 665                 670         





Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys Gln Ile Asp Asp Arg Lys 

        675                 680                 685             





Glu Trp Leu Thr Asn Phe Met Glu Asp Arg Arg Gln Arg Lys Leu Leu 

    690                 695                 700                 





Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln Thr Thr Thr Tyr Leu Thr 

705                 710                 715                 720 





Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp 

                725                 730                 735     





Asn Glu Arg Ser Ile Pro Ser Met Val Asp Gly Leu Lys Pro Gly Gln 

            740                 745                 750         





Arg Lys Val Leu Phe Thr Cys Phe Lys Arg Asn Asp Lys Arg Glu Val 

        755                 760                 765             





Lys Val Ala Gln Leu Ala Gly Ser Val Ala Glu Met Ser Ser Tyr His 

    770                 775                 780                 





His Gly Glu Met Ser Leu Met Met Thr Ile Ile Asn Leu Ala Gln Asn 

785                 790                 795                 800 





Phe Val Gly Ser Asn Asn Leu Asn Leu Leu Gln Pro Ile Gly Gln Phe 

                805                 810                 815     





Gly Thr Arg Leu His Gly Gly Lys Asp Ser Ala Ser Pro Arg Tyr Ile 

            820                 825                 830         





Phe Thr Met Leu Ser Ser Leu Ala Arg Leu Leu Phe Pro Pro Lys Asp 

        835                 840                 845             





Asp His Thr Leu Lys Phe Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro 

    850                 855                 860                 





Glu Trp Tyr Ile Pro Ile Ile Pro Met Val Leu Ile Asn Gly Ala Glu 

865                 870                 875                 880 





Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile Pro Asn Phe Asp Val Arg 

                885                 890                 895     





Glu Ile Val Asn Asn Ile Arg Arg Leu Met Asp Gly Glu Glu Pro Leu 

            900                 905                 910         





Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys Gly Thr Ile Glu Glu Leu 

        915                 920                 925             





Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu Val Ala Ile Leu Asn Ser 

    930                 935                 940                 





Thr Thr Ile Glu Ile Ser Glu Leu Pro Val Arg Thr Trp Thr Gln Thr 

945                 950                 955                 960 





Tyr Lys Glu Gln Val Leu Glu Pro Met Leu Asn Gly Thr Glu Lys Thr 

                965                 970                 975     





Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr His Thr Asp Thr Thr Val 

            980                 985                 990         





Lys Phe Val Val Lys Met Thr Glu  Glu Lys Leu Ala Glu  Ala Glu Arg 

        995                 1000                 1005             





Val Gly  Leu His Lys Val Phe  Lys Leu Gln Thr Ser  Leu Thr Cys 

    1010                 1015                 1020             





Asn Ser  Met Val Leu Phe Asp  His Val Gly Cys Leu  Lys Lys Tyr 

    1025                 1030                 1035             





Asp Thr  Val Leu Asp Ile Leu  Arg Asp Phe Phe Glu  Leu Arg Leu 

    1040                 1045                 1050             





Lys Tyr  Tyr Gly Leu Arg Lys  Glu Trp Leu Leu Gly  Met Leu Gly 

    1055                 1060                 1065             





Ala Glu  Ser Ala Lys Leu Asn  Asn Gln Ala Arg Phe  Ile Leu Glu 

    1070                 1075                 1080             





Lys Ile  Asp Gly Lys Ile Ile  Ile Glu Asn Lys Pro  Lys Lys Glu 

    1085                 1090                 1095             





Leu Ile  Lys Val Leu Ile Gln  Arg Gly Tyr Asp Ser  Asp Pro Val 

    1100                 1105                 1110             





Lys Ala  Trp Lys Glu Ala Gln  Gln Lys Val Pro Asp  Glu Glu Glu 

    1115                 1120                 1125             





Asn Glu  Glu Ser Asp Asn Glu  Lys Glu Thr Glu Lys  Ser Asp Ser 

    1130                 1135                 1140             





Val Thr  Asp Ser Gly Pro Thr  Phe Asn Tyr Leu Leu  Asp Met Pro 

    1145                 1150                 1155             





Leu Trp  Tyr Leu Thr Lys Glu  Lys Lys Asp Glu Leu  Cys Arg Leu 

    1160                 1165                 1170             





Arg Asn  Glu Lys Glu Gln Glu  Leu Asp Thr Leu Lys  Arg Lys Ser 

    1175                 1180                 1185             





Pro Ser  Asp Leu Trp Lys Glu  Asp Leu Ala Thr Phe  Ile Glu Glu 

    1190                 1195                 1200             





Leu Glu  Ala Val Glu Ala Lys  Glu Lys Gln Asp Glu  Gln Val Gly 

    1205                 1210                 1215             





Leu Pro  Gly Lys Gly Gly Lys  Ala Lys Gly Lys Lys  Thr Gln Met 

    1220                 1225                 1230             





Ala Glu  Val Leu Pro Ser Pro  Arg Gly Gln Arg Val  Ile Pro Arg 

    1235                 1240                 1245             





Ile Thr  Ile Glu Met Lys Ala  Glu Ala Glu Lys Lys  Asn Lys Lys 

    1250                 1255                 1260             





Lys Ile  Lys Asn Glu Asn Thr  Glu Gly Ser Pro Gln  Glu Asp Gly 

    1265                 1270                 1275             





Val Glu  Leu Glu Gly Leu Lys  Gln Arg Leu Glu Lys  Lys Gln Lys 

    1280                 1285                 1290             





Arg Glu  Pro Gly Thr Lys Thr  Lys Lys Gln Thr Thr  Leu Ala Phe 

    1295                 1300                 1305             





Lys Pro  Ile Lys Lys Gly Lys  Lys Arg Asn Pro Trp  Ser Asp Ser 

    1310                 1315                 1320             





Glu Ser  Asp Arg Ser Ser Asp  Glu Ser Asn Phe Asp  Val Pro Pro 

    1325                 1330                 1335             





Arg Glu  Thr Glu Pro Arg Arg  Ala Ala Thr Lys Thr  Lys Phe Thr 

    1340                 1345                 1350             





Met Asp  Leu Asp Ser Asp Glu  Asp Phe Ser Asp Phe  Asp Glu Lys 

    1355                 1360                 1365             





Thr Asp  Asp Glu Asp Phe Val  Pro Ser Asp Ala Ser  Pro Pro Lys 

    1370                 1375                 1380             





Thr Lys  Thr Ser Pro Lys Leu  Ser Asn Lys Glu Leu  Lys Pro Gln 

    1385                 1390                 1395             





Lys Ser  Val Val Ser Asp Leu  Glu Ala Asp Asp Val  Lys Gly Ser 

    1400                 1405                 1410             





Val Pro  Leu Ser Ser Ser Pro  Pro Ala Thr His Phe  Pro Asp Glu 

    1415                 1420                 1425             





Thr Glu  Ile Thr Asn Pro Val  Pro Lys Lys Asn Val  Thr Val Lys 

    1430                 1435                 1440             





Lys Thr  Ala Ala Lys Ser Gln  Ser Ser Thr Ser Thr  Thr Gly Ala 

    1445                 1450                 1455             





Lys Lys  Arg Ala Ala Pro Lys  Gly Thr Lys Arg Asp  Pro Ala Leu 

    1460                 1465                 1470             





Asn Ser  Gly Val Ser Gln Lys  Pro Asp Pro Ala Lys  Thr Lys Asn 

    1475                 1480                 1485             





Arg Arg  Lys Arg Lys Pro Ser  Thr Ser Asp Asp Ser  Asp Ser Asn 

    1490                 1495                 1500             





Phe Glu  Lys Ile Val Ser Lys  Ala Val Thr Ser Lys  Lys Ser Lys 

    1505                 1510                 1515             





Gly Glu  Ser Asp Asp Phe His  Met Asp Phe Asp Ser  Ala Val Ala 

    1520                 1525                 1530             





Pro Arg  Ala Lys Ser Val Arg  Ala Lys Lys Pro Ile  Lys Tyr Leu 

    1535                 1540                 1545             





Glu Glu  Ser Asp Glu Asp Asp  Leu Phe 

    1550                 1555         





<210>  45

<211>  1567

<212>  PRT

<213>  Homo sapiens



<400>  45



Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 

1               5                   10                  15      





Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 

            20                  25                  30          





Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 

        35                  40                  45              





Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 

    50                  55                  60                  





Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 

65                  70                  75                  80  





Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 

                85                  90                  95      





Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 

            100                 105                 110         





Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 

        115                 120                 125             





Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 

    130                 135                 140                 





Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 

145                 150                 155                 160 





Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 

                165                 170                 175     





Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 

            180                 185                 190         





Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 

        195                 200                 205             





Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 

    210                 215                 220                 





Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 

225                 230                 235                 240 





Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 

                245                 250                 255     





Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 

            260                 265                 270         





Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 

        275                 280                 285             





Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 

    290                 295                 300                 





Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 

305                 310                 315                 320 





Lys Ser Ser Lys Tyr Trp Ser Ser Arg Lys Ser Lys Gln His Ile Leu 

                325                 330                 335     





Leu Asn Phe Phe Val Leu Phe Lys Phe Ile Asn Asp Ala Phe Phe Gly 

            340                 345                 350         





Ile Cys Pro Phe Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln 

        355                 360                 365             





Ile Val Thr Lys Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly 

    370                 375                 380                 





Val Ala Val Lys Ala His Gln Val Lys Asn His Met Trp Ile Phe Val 

385                 390                 395                 400 





Asn Ala Leu Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn 

                405                 410                 415     





Met Thr Leu Gln Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu 

            420                 425                 430         





Lys Phe Ile Lys Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu 

        435                 440                 445             





Asn Trp Val Lys Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser 

    450                 455                 460                 





Ala Val Lys His Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala 

465                 470                 475                 480 





Asn Asp Ala Gly Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr 

                485                 490                 495     





Glu Gly Asp Ser Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val 

            500                 505                 510         





Gly Arg Asp Lys Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn 

        515                 520                 525             





Val Arg Glu Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn 

    530                 535                 540                 





Asn Ile Ile Lys Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp 

545                 550                 555                 560 





Glu Asp Ser Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr 

                565                 570                 575     





Asp Gln Asp Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe 

            580                 585                 590         





Ile His His Asn Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu 

        595                 600                 605             





Phe Ile Thr Pro Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala 

    610                 615                 620                 





Phe Tyr Ser Leu Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn 

625                 630                 635                 640 





His Lys Lys Trp Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr 

                645                 650                 655     





Ser Lys Glu Ala Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile 

            660                 665                 670         





Gln Phe Lys Tyr Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala 

        675                 680                 685             





Phe Ser Lys Lys Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe 

    690                 695                 700                 





Met Glu Asp Arg Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr 

705                 710                 715                 720 





Leu Tyr Gly Gln Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn 

                725                 730                 735     





Lys Glu Leu Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro 

            740                 745                 750         





Ser Met Val Asp Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr 

        755                 760                 765             





Cys Phe Lys Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala 

    770                 775                 780                 





Gly Ser Val Ala Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu 

785                 790                 795                 800 





Met Met Thr Ile Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn 

                805                 810                 815     





Leu Asn Leu Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly 

            820                 825                 830         





Gly Lys Asp Ser Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser 

        835                 840                 845             





Leu Ala Arg Leu Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe 

    850                 855                 860                 





Leu Tyr Asp Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile 

865                 870                 875                 880 





Ile Pro Met Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp 

                885                 890                 895     





Ser Cys Lys Ile Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile 

            900                 905                 910         





Arg Arg Leu Met Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr 

        915                 920                 925             





Lys Asn Phe Lys Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val 

    930                 935                 940                 





Ile Ser Gly Glu Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser 

945                 950                 955                 960 





Glu Leu Pro Val Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu 

                965                 970                 975     





Glu Pro Met Leu Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp 

            980                 985                 990         





Tyr Arg Glu Tyr His Thr Asp Thr  Thr Val Lys Phe Val  Val Lys Met 

        995                 1000                 1005             





Thr Glu  Glu Lys Leu Ala Glu  Ala Glu Arg Val Gly  Leu His Lys 

    1010                 1015                 1020             





Val Phe  Lys Leu Gln Thr Ser  Leu Thr Cys Asn Ser  Met Val Leu 

    1025                 1030                 1035             





Phe Asp  His Val Gly Cys Leu  Lys Lys Tyr Asp Thr  Val Leu Asp 

    1040                 1045                 1050             





Ile Leu  Arg Asp Phe Phe Glu  Leu Arg Leu Lys Tyr  Tyr Gly Leu 

    1055                 1060                 1065             





Arg Lys  Glu Trp Leu Leu Gly  Met Leu Gly Ala Glu  Ser Ala Lys 

    1070                 1075                 1080             





Leu Asn  Asn Gln Ala Arg Phe  Ile Leu Glu Lys Ile  Asp Gly Lys 

    1085                 1090                 1095             





Ile Ile  Ile Glu Asn Lys Pro  Lys Lys Glu Leu Ile  Lys Val Leu 

    1100                 1105                 1110             





Ile Gln  Arg Gly Tyr Asp Ser  Asp Pro Val Lys Ala  Trp Lys Glu 

    1115                 1120                 1125             





Ala Gln  Gln Lys Val Pro Asp  Glu Glu Glu Asn Glu  Glu Ser Asp 

    1130                 1135                 1140             





Asn Glu  Lys Glu Thr Glu Lys  Ser Asp Ser Val Thr  Asp Ser Gly 

    1145                 1150                 1155             





Pro Thr  Phe Asn Tyr Leu Leu  Asp Met Pro Leu Trp  Tyr Leu Thr 

    1160                 1165                 1170             





Lys Glu  Lys Lys Asp Glu Leu  Cys Arg Leu Arg Asn  Glu Lys Glu 

    1175                 1180                 1185             





Gln Glu  Leu Asp Thr Leu Lys  Arg Lys Ser Pro Ser  Asp Leu Trp 

    1190                 1195                 1200             





Lys Glu  Asp Leu Ala Thr Phe  Ile Glu Glu Leu Glu  Ala Val Glu 

    1205                 1210                 1215             





Ala Lys  Glu Lys Gln Asp Glu  Gln Val Gly Leu Pro  Gly Lys Gly 

    1220                 1225                 1230             





Gly Lys  Ala Lys Gly Lys Lys  Thr Gln Met Ala Glu  Val Leu Pro 

    1235                 1240                 1245             





Ser Pro  Arg Gly Gln Arg Val  Ile Pro Arg Ile Thr  Ile Glu Met 

    1250                 1255                 1260             





Lys Ala  Glu Ala Glu Lys Lys  Asn Lys Lys Lys Ile  Lys Asn Glu 

    1265                 1270                 1275             





Asn Thr  Glu Gly Ser Pro Gln  Glu Asp Gly Val Glu  Leu Glu Gly 

    1280                 1285                 1290             





Leu Lys  Gln Arg Leu Glu Lys  Lys Gln Lys Arg Glu  Pro Gly Thr 

    1295                 1300                 1305             





Lys Thr  Lys Lys Gln Thr Thr  Leu Ala Phe Lys Pro  Ile Lys Lys 

    1310                 1315                 1320             





Gly Lys  Lys Arg Asn Pro Trp  Ser Asp Ser Glu Ser  Asp Arg Ser 

    1325                 1330                 1335             





Ser Asp  Glu Ser Asn Phe Asp  Val Pro Pro Arg Glu  Thr Glu Pro 

    1340                 1345                 1350             





Arg Arg  Ala Ala Thr Lys Thr  Lys Phe Thr Met Asp  Leu Asp Ser 

    1355                 1360                 1365             





Asp Glu  Asp Phe Ser Asp Phe  Asp Glu Lys Thr Asp  Asp Glu Asp 

    1370                 1375                 1380             





Phe Val  Pro Ser Asp Ala Ser  Pro Pro Lys Thr Lys  Thr Ser Pro 

    1385                 1390                 1395             





Lys Leu  Ser Asn Lys Glu Leu  Lys Pro Gln Lys Ser  Val Val Ser 

    1400                 1405                 1410             





Asp Leu  Glu Ala Asp Asp Val  Lys Gly Ser Val Pro  Leu Ser Ser 

    1415                 1420                 1425             





Ser Pro  Pro Ala Thr His Phe  Pro Asp Glu Thr Glu  Ile Thr Asn 

    1430                 1435                 1440             





Pro Val  Pro Lys Lys Asn Val  Thr Val Lys Lys Thr  Ala Ala Lys 

    1445                 1450                 1455             





Ser Gln  Ser Ser Thr Ser Thr  Thr Gly Ala Lys Lys  Arg Ala Ala 

    1460                 1465                 1470             





Pro Lys  Gly Thr Lys Arg Asp  Pro Ala Leu Asn Ser  Gly Val Ser 

    1475                 1480                 1485             





Gln Lys  Pro Asp Pro Ala Lys  Thr Lys Asn Arg Arg  Lys Arg Lys 

    1490                 1495                 1500             





Pro Ser  Thr Ser Asp Asp Ser  Asp Ser Asn Phe Glu  Lys Ile Val 

    1505                 1510                 1515             





Ser Lys  Ala Val Thr Ser Lys  Lys Ser Lys Gly Glu  Ser Asp Asp 

    1520                 1525                 1530             





Phe His  Met Asp Phe Asp Ser  Ala Val Ala Pro Arg  Ala Lys Ser 

    1535                 1540                 1545             





Val Arg  Ala Lys Lys Pro Ile  Lys Tyr Leu Glu Glu  Ser Asp Glu 

    1550                 1555                 1560             





Asp Asp  Leu Phe 

    1565         





<210>  46

<211>  1612

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 

1               5                   10                  15      





Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 

            20                  25                  30          





Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 

        35                  40                  45              





Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 

    50                  55                  60                  





Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 

65                  70                  75                  80  





Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 

                85                  90                  95      





Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 

            100                 105                 110         





Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 

        115                 120                 125             





Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 

    130                 135                 140                 





Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 

145                 150                 155                 160 





Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 

                165                 170                 175     





Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 

            180                 185                 190         





Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 

        195                 200                 205             





Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 

    210                 215                 220                 





Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 

225                 230                 235                 240 





Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 

                245                 250                 255     





Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 

            260                 265                 270         





Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 

        275                 280                 285             





Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 

    290                 295                 300                 





Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 

305                 310                 315                 320 





Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 

                325                 330                 335     





Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 

            340                 345                 350         





Ala His Gln Arg Glu Leu Cys Asn Gly Ala Ile Leu Ala His Cys Asn 

        355                 360                 365             





Leu Arg Leu Met Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val 

    370                 375                 380                 





Ala Gly Ile Ala Gly Gly Cys His His Thr Gln Leu Ile Phe Val Phe 

385                 390                 395                 400 





Leu Val Glu Thr Gly Phe His His Val Gly Gln Ala Gly Leu Glu Arg 

                405                 410                 415     





Leu Thr Ser Gly Asp Pro Pro Ala Ser Ala Ser Gln Ser Ser Gly Ile 

            420                 425                 430         





Thr Asp Val Lys Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu 

        435                 440                 445             





Ile Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu 

    450                 455                 460                 





Gln Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile 

465                 470                 475                 480 





Lys Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val 

                485                 490                 495     





Lys Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys 

            500                 505                 510         





His Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala 

        515                 520                 525             





Gly Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp 

    530                 535                 540                 





Ser Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp 

545                 550                 555                 560 





Lys Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu 

                565                 570                 575     





Ala Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile 

            580                 585                 590         





Lys Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser 

        595                 600                 605             





Leu Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp 

    610                 615                 620                 





Gln Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His 

625                 630                 635                 640 





Asn Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr 

                645                 650                 655     





Pro Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser 

            660                 665                 670         





Leu Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys 

        675                 680                 685             





Trp Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu 

    690                 695                 700                 





Ala Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys 

705                 710                 715                 720 





Tyr Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys 

                725                 730                 735     





Lys Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp 

            740                 745                 750         





Arg Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly 

        755                 760                 765             





Gln Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu 

    770                 775                 780                 





Ile Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val 

785                 790                 795                 800 





Asp Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys 

                805                 810                 815     





Arg Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val 

            820                 825                 830         





Ala Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr 

        835                 840                 845             





Ile Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu 

    850                 855                 860                 





Leu Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp 

865                 870                 875                 880 





Ser Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg 

                885                 890                 895     





Leu Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp 

            900                 905                 910         





Asp Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met 

        915                 920                 925             





Val Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys 

    930                 935                 940                 





Ile Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu 

945                 950                 955                 960 





Met Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe 

                965                 970                 975     





Lys Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly 

            980                 985                 990         





Glu Val Ala Ile Leu Asn Ser Thr  Thr Ile Glu Ile Ser  Glu Leu Pro 

        995                 1000                 1005             





Val Arg  Thr Trp Thr Gln Thr  Tyr Lys Glu Gln Val  Leu Glu Pro 

    1010                 1015                 1020             





Met Leu  Asn Gly Thr Glu Lys  Thr Pro Pro Leu Ile  Thr Asp Tyr 

    1025                 1030                 1035             





Arg Glu  Tyr His Thr Asp Thr  Thr Val Lys Phe Val  Val Lys Met 

    1040                 1045                 1050             





Thr Glu  Glu Lys Leu Ala Glu  Ala Glu Arg Val Gly  Leu His Lys 

    1055                 1060                 1065             





Val Phe  Lys Leu Gln Thr Ser  Leu Thr Cys Asn Ser  Met Val Leu 

    1070                 1075                 1080             





Phe Asp  His Val Gly Cys Leu  Lys Lys Tyr Asp Thr  Val Leu Asp 

    1085                 1090                 1095             





Ile Leu  Arg Asp Phe Phe Glu  Leu Arg Leu Lys Tyr  Tyr Gly Leu 

    1100                 1105                 1110             





Arg Lys  Glu Trp Leu Leu Gly  Met Leu Gly Ala Glu  Ser Ala Lys 

    1115                 1120                 1125             





Leu Asn  Asn Gln Ala Arg Phe  Ile Leu Glu Lys Ile  Asp Gly Lys 

    1130                 1135                 1140             





Ile Ile  Ile Glu Asn Lys Pro  Lys Lys Glu Leu Ile  Lys Val Leu 

    1145                 1150                 1155             





Ile Gln  Arg Gly Tyr Asp Ser  Asp Pro Val Lys Ala  Trp Lys Glu 

    1160                 1165                 1170             





Ala Gln  Gln Lys Val Pro Asp  Glu Glu Glu Asn Glu  Glu Ser Asp 

    1175                 1180                 1185             





Asn Glu  Lys Glu Thr Glu Lys  Ser Asp Ser Val Thr  Asp Ser Gly 

    1190                 1195                 1200             





Pro Thr  Phe Asn Tyr Leu Leu  Asp Met Pro Leu Trp  Tyr Leu Thr 

    1205                 1210                 1215             





Lys Glu  Lys Lys Asp Glu Leu  Cys Arg Leu Arg Asn  Glu Lys Glu 

    1220                 1225                 1230             





Gln Glu  Leu Asp Thr Leu Lys  Arg Lys Ser Pro Ser  Asp Leu Trp 

    1235                 1240                 1245             





Lys Glu  Asp Leu Ala Thr Phe  Ile Glu Glu Leu Glu  Ala Val Glu 

    1250                 1255                 1260             





Ala Lys  Glu Lys Gln Asp Glu  Gln Val Gly Leu Pro  Gly Lys Gly 

    1265                 1270                 1275             





Gly Lys  Ala Lys Gly Lys Lys  Thr Gln Met Ala Glu  Val Leu Pro 

    1280                 1285                 1290             





Ser Pro  Arg Gly Gln Arg Val  Ile Pro Arg Ile Thr  Ile Glu Met 

    1295                 1300                 1305             





Lys Ala  Glu Ala Glu Lys Lys  Asn Lys Lys Lys Ile  Lys Asn Glu 

    1310                 1315                 1320             





Asn Thr  Glu Gly Ser Pro Gln  Glu Asp Gly Val Glu  Leu Glu Gly 

    1325                 1330                 1335             





Leu Lys  Gln Arg Leu Glu Lys  Lys Gln Lys Arg Glu  Pro Gly Thr 

    1340                 1345                 1350             





Lys Thr  Lys Lys Gln Thr Thr  Leu Ala Phe Lys Pro  Ile Lys Lys 

    1355                 1360                 1365             





Gly Lys  Lys Arg Asn Pro Trp  Ser Asp Ser Glu Ser  Asp Arg Ser 

    1370                 1375                 1380             





Ser Asp  Glu Ser Asn Phe Asp  Val Pro Pro Arg Glu  Thr Glu Pro 

    1385                 1390                 1395             





Arg Arg  Ala Ala Thr Lys Thr  Lys Phe Thr Met Asp  Leu Asp Ser 

    1400                 1405                 1410             





Asp Glu  Asp Phe Ser Asp Phe  Asp Glu Lys Thr Asp  Asp Glu Asp 

    1415                 1420                 1425             





Phe Val  Pro Ser Asp Ala Ser  Pro Pro Lys Thr Lys  Thr Ser Pro 

    1430                 1435                 1440             





Lys Leu  Ser Asn Lys Glu Leu  Lys Pro Gln Lys Ser  Val Val Ser 

    1445                 1450                 1455             





Asp Leu  Glu Ala Asp Asp Val  Lys Gly Ser Val Pro  Leu Ser Ser 

    1460                 1465                 1470             





Ser Pro  Pro Ala Thr His Phe  Pro Asp Glu Thr Glu  Ile Thr Asn 

    1475                 1480                 1485             





Pro Val  Pro Lys Lys Asn Val  Thr Val Lys Lys Thr  Ala Ala Lys 

    1490                 1495                 1500             





Ser Gln  Ser Ser Thr Ser Thr  Thr Gly Ala Lys Lys  Arg Ala Ala 

    1505                 1510                 1515             





Pro Lys  Gly Thr Lys Arg Asp  Pro Ala Leu Asn Ser  Gly Val Ser 

    1520                 1525                 1530             





Gln Lys  Pro Asp Pro Ala Lys  Thr Lys Asn Arg Arg  Lys Arg Lys 

    1535                 1540                 1545             





Pro Ser  Thr Ser Asp Asp Ser  Asp Ser Asn Phe Glu  Lys Ile Val 

    1550                 1555                 1560             





Ser Lys  Ala Val Thr Ser Lys  Lys Ser Lys Gly Glu  Ser Asp Asp 

    1565                 1570                 1575             





Phe His  Met Asp Phe Asp Ser  Ala Val Ala Pro Arg  Ala Lys Ser 

    1580                 1585                 1590             





Val Arg  Ala Lys Lys Pro Ile  Lys Tyr Leu Glu Glu  Ser Asp Glu 

    1595                 1600                 1605             





Asp Asp  Leu Phe 

    1610         





<210>  47

<211>  247

<212>  PRT

<213>  Homo sapiens



<400>  47



Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 

1               5                   10                  15      





Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 

            20                  25                  30          





Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 

        35                  40                  45              





Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 

    50                  55                  60                  





His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 

65                  70                  75                  80  





Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 

                85                  90                  95      





Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 

            100                 105                 110         





Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 

        115                 120                 125             





His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 

    130                 135                 140                 





Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 

145                 150                 155                 160 





Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 

                165                 170                 175     





Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 

            180                 185                 190         





Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 

        195                 200                 205             





Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 

    210                 215                 220                 





Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 

225                 230                 235                 240 





Leu Thr Ile Lys Arg Gly Arg 

                245         





<210>  48

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  48



Met Phe His Gln Val Arg Arg Val Met Thr Ile Leu Phe Leu Thr Met 

1               5                   10                  15      





Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala Pro Met Lys Glu Ala 

            20                  25                  30          





Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro Gly Val Arg Thr His 

        35                  40                  45              





Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu 

    50                  55                  60                  





Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile Glu Glu Leu Leu Asp 

65                  70                  75                  80  





Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp 

                85                  90                  95      





Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln Val Pro Leu Glu Pro 

            100                 105                 110         





Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala 

        115                 120                 125             





Asn Met Ser Met Arg Val Arg Arg His Ser Asp Pro Ala Arg Arg Gly 

    130                 135                 140                 





Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp Val Thr Ala Ala Asp 

145                 150                 155                 160 





Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr Val Thr Val Leu Glu 

                165                 170                 175     





Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr 

            180                 185                 190         





Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp 

        195                 200                 205             





Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg 

    210                 215                 220                 





Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg 

225                 230                 235                 240 





Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile Lys Arg Gly Arg 

                245                 250                 255 





<210>  49

<211>  262

<212>  PRT

<213>  Homo sapiens



<400>  49



Met Gln Ser Arg Glu Glu Glu Trp Phe His Gln Val Arg Arg Val Met 

1               5                   10                  15      





Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys 

            20                  25                  30          





Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala 

        35                  40                  45              





Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro 

    50                  55                  60                  





Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His 

65                  70                  75                  80  





Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu 

                85                  90                  95      





Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser 

            100                 105                 110         





Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr 

        115                 120                 125             





Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His 

    130                 135                 140                 





Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser 

145                 150                 155                 160 





Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly 

                165                 170                 175     





Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu 

            180                 185                 190         





Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys 

        195                 200                 205             





Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg 

    210                 215                 220                 





Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg 

225                 230                 235                 240 





Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu 

                245                 250                 255     





Thr Ile Lys Arg Gly Arg 

            260         





<210>  50

<211>  329

<212>  PRT

<213>  Homo sapiens



<400>  50



Met Cys Gly Ala Thr Ser Phe Leu His Glu Cys Thr Arg Leu Ile Leu 

1               5                   10                  15      





Val Thr Thr Gln Asn Ala Glu Phe Leu Gln Lys Gly Leu Gln Val His 

            20                  25                  30          





Thr Cys Phe Gly Val Tyr Pro His Ala Ser Val Trp His Asp Cys Ala 

        35                  40                  45              





Ser Gln Lys Lys Gly Cys Ala Val Tyr Leu His Val Ser Val Glu Phe 

    50                  55                  60                  





Asn Lys Leu Ile Pro Glu Asn Gly Phe Ile Lys Phe His Gln Val Arg 

65                  70                  75                  80  





Arg Val Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly 

                85                  90                  95      





Cys Met Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly 

            100                 105                 110         





Gly Leu Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val 

        115                 120                 125             





Asn Gly Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr 

    130                 135                 140                 





Phe Glu His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg 

145                 150                 155                 160 





Pro Asn Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val 

                165                 170                 175     





Met Leu Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu 

            180                 185                 190         





Glu Glu Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val 

        195                 200                 205             





Arg Arg His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp 

    210                 215                 220                 





Ser Ile Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 

225                 230                 235                 240 





Met Ser Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys 

                245                 250                 255     





Gly Gln Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly 

            260                 265                 270         





Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser 

        275                 280                 285             





Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 

    290                 295                 300                 





Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val 

305                 310                 315                 320 





Cys Thr Leu Thr Ile Lys Arg Gly Arg 

                325                 





<210>  51

<211>  276

<212>  PRT

<213>  Homo sapiens



<400>  51



Met Leu Cys Ala Ile Ser Leu Cys Ala Arg Val Arg Lys Leu Arg Ser 

1               5                   10                  15      





Ala Gly Arg Cys Gly Lys Phe His Gln Val Arg Arg Val Met Thr Ile 

            20                  25                  30          





Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met Lys Ala Ala 

        35                  40                  45              





Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu Ala Tyr Pro 

    50                  55                  60                  





Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly Pro Lys Ala 

65                  70                  75                  80  





Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu His Val Ile 

                85                  90                  95      





Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn Glu Glu Asn 

            100                 105                 110         





Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu Ser Ser Gln 

        115                 120                 125             





Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu Tyr Lys Asn 

    130                 135                 140                 





Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg His Ser Asp 

145                 150                 155                 160 





Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile Ser Glu Trp 

                165                 170                 175     





Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser Gly Gly Thr 

            180                 185                 190         





Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln Leu Lys Gln 

        195                 200                 205             





Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr Lys Glu Gly 

    210                 215                 220                 





Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys Arg Thr Thr 

225                 230                 235                 240 





Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys Arg Ile Gly 

                245                 250                 255     





Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr Leu Thr Ile 

            260                 265                 270         





Lys Arg Gly Arg 

        275     





<210>  52

<211>  479

<212>  PRT

<213>  Homo sapiens



<400>  52



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 

            180                 185                 190         





Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 

        195                 200                 205             





Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 

    210                 215                 220                 





Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 

225                 230                 235                 240 





Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 

                245                 250                 255     





Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr 

            260                 265                 270         





Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr 

        275                 280                 285             





Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 

    290                 295                 300                 





Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 

305                 310                 315                 320 





Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 

                325                 330                 335     





Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 

            340                 345                 350         





Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 

        355                 360                 365             





Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 

    370                 375                 380                 





Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 

385                 390                 395                 400 





Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 

                405                 410                 415     





Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 

            420                 425                 430         





Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr 

        435                 440                 445             





Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 

    450                 455                 460                 





Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

465                 470                 475                 





<210>  53

<211>  464

<212>  PRT

<213>  Homo sapiens



<400>  53



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 

            180                 185                 190         





Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 

        195                 200                 205             





Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 

    210                 215                 220                 





Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 

225                 230                 235                 240 





Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 

                245                 250                 255     





Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 

            260                 265                 270         





Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 

        275                 280                 285             





His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 

    290                 295                 300                 





Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 

305                 310                 315                 320 





Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 

                325                 330                 335     





Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 

            340                 345                 350         





Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 

        355                 360                 365             





Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 

    370                 375                 380                 





Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 

385                 390                 395                 400 





Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 

                405                 410                 415     





Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 

            420                 425                 430         





Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 

        435                 440                 445             





Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

    450                 455                 460                 





<210>  54

<211>  395

<212>  PRT

<213>  Homo sapiens



<400>  54



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Gly Ala Leu Thr Thr Thr Phe Glu Glu 

            180                 185                 190         





Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile 

        195                 200                 205             





Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp 

    210                 215                 220                 





Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr 

225                 230                 235                 240 





Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe 

                245                 250                 255     





Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe 

            260                 265                 270         





Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu 

        275                 280                 285             





Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro 

    290                 295                 300                 





Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala 

305                 310                 315                 320 





Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp 

                325                 330                 335     





Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly 

            340                 345                 350         





Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn 

        355                 360                 365             





Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe 

    370                 375                 380                 





Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

385                 390                 395 





<210>  55

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  55



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 

            100                 105                 110         





Ala Asn Ser Gln Cys Gln Thr Gln Ser Val Pro Phe Trp Arg Arg Val 

        115                 120                 125             





Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

    130                 135                 140                 





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

145                 150                 155                 160 





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

                165                 170                 175     





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

            180                 185                 190         





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

        195                 200                 205             





Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 

    210                 215                 220                 





Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 

225                 230                 235                 240 





Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 

                245                 250                 255     





Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 

            260                 265                 270         





Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 

        275                 280                 285             





Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 

    290                 295                 300                 





Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 

305                 310                 315                 320 





His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 

                325                 330                 335     





Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 

            340                 345                 350         





Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 

        355                 360                 365             





Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 

    370                 375                 380                 





Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 

385                 390                 395                 400 





Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 

                405                 410                 415     





Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 

            420                 425                 430         





Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 

        435                 440                 445             





Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 

    450                 455                 460                 





Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 

465                 470                 475                 480 





Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

                485                 490                 495     





<210>  56

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  56



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 

            180                 185                 190         





Pro Asp Glu Phe Ser Asn Asp Phe Gly Gln Ser Leu Pro Asn Glu Lys 

        195                 200                 205             





Gln Thr Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys Lys 

    210                 215                 220                 





Ser Thr Gly Glu Ser Ala Gln Thr Ser Gln His 

225                 230                 235 





<210>  57

<211>  220

<212>  PRT

<213>  Homo sapiens



<400>  57



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Asp Phe Gly Gln Ser Leu Pro Asn Glu 

            180                 185                 190         





Lys Gln Thr Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys 

        195                 200                 205             





Lys Ser Thr Gly Glu Ser Ala Gln Thr Ser Gln His 

    210                 215                 220 





<210>  58

<211>  276

<212>  PRT

<213>  Homo sapiens



<400>  58



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 

            180                 185                 190         





Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 

        195                 200                 205             





Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 

    210                 215                 220                 





Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 

225                 230                 235                 240 





Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 

                245                 250                 255     





Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Thr Val Glu Pro 

            260                 265                 270         





Lys Arg Glu Lys 

        275     





<210>  59

<211>  261

<212>  PRT

<213>  Homo sapiens



<400>  59



Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 

1               5                   10                  15      





Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 

            20                  25                  30          





Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 

        35                  40                  45              





Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 

    50                  55                  60                  





Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 

65                  70                  75                  80  





Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 

                85                  90                  95      





Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 

            100                 105                 110         





Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 

        115                 120                 125             





Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 

    130                 135                 140                 





Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 

145                 150                 155                 160 





Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 

                165                 170                 175     





Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 

            180                 185                 190         





Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 

        195                 200                 205             





Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 

    210                 215                 220                 





Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 

225                 230                 235                 240 





Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Thr Val Glu 

                245                 250                 255     





Pro Lys Arg Glu Lys 

            260     





<210>  60

<211>  538

<212>  PRT

<213>  Homo sapiens



<400>  60



Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 

1               5                   10                  15      





Phe Phe Leu Gly Ala Phe Pro Thr Pro Phe Pro Ala Glu His Val Glu 

            20                  25                  30          





Leu Gly Arg Leu Gly Asp Ser Glu Thr Ala Met Val Pro Gly Lys Gly 

        35                  40                  45              





Gly Ala Asp Tyr Ile Leu Leu Pro Phe Lys Lys Met Asp Phe Ser Arg 

    50                  55                  60                  





Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser Glu Asp Leu Ala Ser 

65                  70                  75                  80  





Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln Arg Lys Gln Glu Pro 

                85                  90                  95      





Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu Gln Glu Lys Arg Met 

            100                 105                 110         





Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu Leu Leu Phe Arg Ile 

        115                 120                 125             





Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn Thr Arg Lys Glu Glu 

    130                 135                 140                 





Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala Gln Ile Ser Ala Tyr 

145                 150                 155                 160 





Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu 

                165                 170                 175     





Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu 

            180                 185                 190         





Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg 

        195                 200                 205             





Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala 

    210                 215                 220                 





Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe 

225                 230                 235                 240 





Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser Pro Asp Glu Phe Ser 

                245                 250                 255     





Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile Ser Asp Ser Pro Arg 

            260                 265                 270         





Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys 

        275                 280                 285             





Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala 

    290                 295                 300                 





Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn 

305                 310                 315                 320 





Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu 

                325                 330                 335     





His Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr 

            340                 345                 350         





Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys 

        355                 360                 365             





Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly 

    370                 375                 380                 





Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr 

385                 390                 395                 400 





Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile 

                405                 410                 415     





Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr 

            420                 425                 430         





Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro Gln 

        435                 440                 445             





Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Thr 

    450                 455                 460                 





Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp Tyr 

465                 470                 475                 480 





Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp 

                485                 490                 495     





Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn Lys 

            500                 505                 510         





Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe Thr 

        515                 520                 525             





Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 

    530                 535             





<210>  61

<211>  97

<212>  PRT

<213>  Homo sapiens



<400>  61



Met Lys Val Ser Ala Ala Leu Leu Trp Leu Leu Leu Ile Ala Ala Ala 

1               5                   10                  15      





Phe Ser Pro Gln Gly Leu Ala Gly Pro Ala Ser Val Pro Thr Thr Cys 

            20                  25                  30          





Cys Phe Asn Leu Ala Asn Arg Lys Ile Pro Leu Gln Arg Leu Glu Ser 

        35                  40                  45              





Tyr Arg Arg Ile Thr Ser Gly Lys Cys Pro Gln Lys Ala Val Ile Phe 

    50                  55                  60                  





Lys Thr Lys Leu Ala Lys Asp Ile Cys Ala Asp Pro Lys Lys Lys Trp 

65                  70                  75                  80  





Val Gln Asp Ser Met Lys Tyr Leu Asp Gln Lys Ser Pro Thr Pro Lys 

                85                  90                  95      





Pro 

    





<210>  62

<211>  92

<212>  PRT

<213>  Homo sapiens



<400>  62



Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 

1               5                   10                  15      





Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 

            20                  25                  30          





Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 

        35                  40                  45              





Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 

    50                  55                  60                  





Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 

65                  70                  75                  80  





Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 

                85                  90          





<210>  63

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  63



Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 

1               5                   10                  15      





Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 

            20                  25                  30          





Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 

        35                  40                  45              





Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 

    50                  55                  60                  





Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 

65                  70                  75                  80  





Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 

                85                  90      





<210>  64

<211>  375

<212>  PRT

<213>  Homo sapiens



<400>  64



Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 

1               5                   10                  15      





Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 

            20                  25                  30          





Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 

        35                  40                  45              





Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 

    50                  55                  60                  





Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 

65                  70                  75                  80  





Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 

                85                  90                  95      





Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 

            100                 105                 110         





Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 

        115                 120                 125             





Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 

    130                 135                 140                 





Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 

145                 150                 155                 160 





Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 

                165                 170                 175     





Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 

            180                 185                 190         





Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 

        195                 200                 205             





Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 

    210                 215                 220                 





Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 

225                 230                 235                 240 





Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 

                245                 250                 255     





Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 

            260                 265                 270         





Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 

        275                 280                 285             





Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 

    290                 295                 300                 





Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 

305                 310                 315                 320 





Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 

                325                 330                 335     





Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 

            340                 345                 350         





Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 

        355                 360                 365             





Gln Gly Ala Arg Gly Phe Ala 

    370                 375 





<210>  65

<211>  371

<212>  PRT

<213>  Homo sapiens



<400>  65



Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly 

1               5                   10                  15      





Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile 

            20                  25                  30          





Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala 

        35                  40                  45              





Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly 

    50                  55                  60                  





Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His 

65                  70                  75                  80  





Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr 

                85                  90                  95      





Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp 

            100                 105                 110         





Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 

        115                 120                 125             





Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 

    130                 135                 140                 





Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 

145                 150                 155                 160 





Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 

                165                 170                 175     





Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 

            180                 185                 190         





Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 

        195                 200                 205             





Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 

    210                 215                 220                 





Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 

225                 230                 235                 240 





Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 

                245                 250                 255     





Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 

            260                 265                 270         





Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 

        275                 280                 285             





Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 

    290                 295                 300                 





Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 

305                 310                 315                 320 





Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 

                325                 330                 335     





Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 

            340                 345                 350         





Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 

        355                 360                 365             





Val Ala Leu 

    370     





<210>  66

<211>  233

<212>  PRT

<213>  Homo sapiens



<400>  66



Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly 

1               5                   10                  15      





Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile 

            20                  25                  30          





Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala 

        35                  40                  45              





Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly 

    50                  55                  60                  





Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His 

65                  70                  75                  80  





Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr 

                85                  90                  95      





Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp 

            100                 105                 110         





Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 

        115                 120                 125             





Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 

    130                 135                 140                 





Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 

145                 150                 155                 160 





Gln Thr Gln Ser Arg Ser Val Thr Gln Ala Gly Val Gln Trp Cys Asp 

                165                 170                 175     





Leu Cys Leu Leu Gln Pro Ser Pro Pro Arg Phe Lys Arg Phe Ser Cys 

            180                 185                 190         





Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg His Pro Pro Pro Arg Leu 

        195                 200                 205             





Ala Asn Phe Cys Ile Ile Ser Arg Asp Gly Val Ser Pro Cys Trp Pro 

    210                 215                 220                 





Gly Trp Ser Arg Thr Cys Asp Leu Arg 

225                 230             





<210>  67

<211>  259

<212>  PRT

<213>  Homo sapiens



<400>  67



Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 

1               5                   10                  15      





Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 

            20                  25                  30          





Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 

        35                  40                  45              





Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 

    50                  55                  60                  





Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 

65                  70                  75                  80  





Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 

                85                  90                  95      





Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 

            100                 105                 110         





Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 

        115                 120                 125             





Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 

    130                 135                 140                 





Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 

145                 150                 155                 160 





Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 

                165                 170                 175     





Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 

            180                 185                 190         





Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 

        195                 200                 205             





Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 

    210                 215                 220                 





Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 

225                 230                 235                 240 





Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 

                245                 250                 255     





Val Ala Leu 

            





<210>  68

<211>  586

<212>  PRT

<213>  Homo sapiens



<400>  68



Met Ala Thr Ala Thr Pro Val Pro Pro Arg Met Gly Ser Arg Ala Gly 

1               5                   10                  15      





Gly Pro Thr Thr Pro Leu Ser Pro Thr Arg Leu Ser Arg Leu Gln Glu 

            20                  25                  30          





Lys Glu Glu Leu Arg Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp 

        35                  40                  45              





Lys Val Arg Ser Leu Glu Thr Glu Asn Ser Ala Leu Gln Leu Gln Val 

    50                  55                  60                  





Thr Glu Arg Glu Glu Val Arg Gly Arg Glu Leu Thr Gly Leu Lys Ala 

65                  70                  75                  80  





Leu Tyr Glu Thr Glu Leu Ala Asp Ala Arg Arg Ala Leu Asp Asp Thr 

                85                  90                  95      





Ala Arg Glu Arg Ala Lys Leu Gln Ile Glu Leu Gly Lys Cys Lys Ala 

            100                 105                 110         





Glu His Asp Gln Leu Leu Leu Asn Tyr Ala Lys Lys Glu Ser Asp Leu 

        115                 120                 125             





Asn Gly Ala Gln Ile Lys Leu Arg Glu Tyr Glu Ala Ala Leu Asn Ser 

    130                 135                 140                 





Lys Asp Ala Ala Leu Ala Thr Ala Leu Gly Asp Lys Lys Ser Leu Glu 

145                 150                 155                 160 





Gly Asp Leu Glu Asp Leu Lys Asp Gln Ile Ala Gln Leu Glu Ala Ser 

                165                 170                 175     





Leu Ala Ala Ala Lys Lys Gln Leu Ala Asp Glu Thr Leu Leu Lys Val 

            180                 185                 190         





Asp Leu Glu Asn Arg Cys Gln Ser Leu Thr Glu Asp Leu Glu Phe Arg 

        195                 200                 205             





Lys Ser Met Tyr Glu Glu Glu Ile Asn Glu Thr Arg Arg Lys His Glu 

    210                 215                 220                 





Thr Arg Leu Val Glu Val Asp Ser Gly Arg Gln Ile Glu Tyr Glu Tyr 

225                 230                 235                 240 





Lys Leu Ala Gln Ala Leu His Glu Met Arg Glu Gln His Asp Ala Gln 

                245                 250                 255     





Val Arg Leu Tyr Lys Glu Glu Leu Glu Gln Thr Tyr His Ala Lys Leu 

            260                 265                 270         





Glu Asn Ala Arg Leu Ser Ser Glu Met Asn Thr Ser Thr Val Asn Ser 

        275                 280                 285             





Ala Arg Glu Glu Leu Met Glu Ser Arg Met Arg Ile Glu Ser Leu Ser 

    290                 295                 300                 





Ser Gln Leu Ser Asn Leu Gln Lys Glu Ser Arg Ala Cys Leu Glu Arg 

305                 310                 315                 320 





Ile Gln Glu Leu Glu Asp Leu Leu Ala Lys Glu Lys Asp Asn Ser Arg 

                325                 330                 335     





Arg Met Leu Thr Asp Lys Glu Arg Glu Met Ala Glu Ile Arg Asp Gln 

            340                 345                 350         





Met Gln Gln Gln Leu Asn Asp Tyr Glu Gln Leu Leu Asp Val Lys Leu 

        355                 360                 365             





Ala Leu Asp Met Glu Ile Ser Ala Tyr Arg Lys Leu Leu Glu Gly Glu 

    370                 375                 380                 





Glu Glu Arg Leu Lys Leu Ser Pro Ser Pro Ser Ser Arg Val Thr Val 

385                 390                 395                 400 





Ser Arg Ala Ser Ser Ser Arg Ser Val Arg Thr Thr Arg Gly Lys Arg 

                405                 410                 415     





Lys Arg Val Asp Val Glu Glu Ser Glu Ala Ser Ser Ser Val Ser Ile 

            420                 425                 430         





Ser His Ser Ala Ser Ala Thr Gly Asn Val Cys Ile Glu Glu Ile Asp 

        435                 440                 445             





Val Asp Gly Lys Phe Ile Arg Leu Lys Asn Thr Ser Glu Gln Asp Gln 

    450                 455                 460                 





Pro Met Gly Gly Trp Glu Met Ile Arg Lys Ile Gly Asp Thr Ser Val 

465                 470                 475                 480 





Ser Tyr Lys Tyr Thr Ser Arg Tyr Val Leu Lys Ala Gly Gln Thr Val 

                485                 490                 495     





Thr Ile Trp Ala Ala Asn Ala Gly Val Thr Ala Ser Pro Pro Thr Asp 

            500                 505                 510         





Leu Ile Trp Lys Asn Gln Asn Ser Trp Gly Thr Gly Glu Asp Val Lys 

        515                 520                 525             





Val Ile Leu Lys Asn Ser Gln Gly Glu Glu Val Ala Gln Arg Ser Thr 

    530                 535                 540                 





Val Phe Lys Thr Thr Ile Pro Glu Glu Glu Glu Glu Glu Glu Glu Ala 

545                 550                 555                 560 





Ala Gly Val Val Val Glu Glu Glu Leu Phe His Gln Gln Gly Thr Pro 

                565                 570                 575     





Arg Ala Ser Asn Arg Ser Cys Ala Ile Met 

            580                 585     





<210>  69

<211>  393

<212>  PRT

<213>  Homo sapiens



<400>  69



Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 

1               5                   10                  15      





Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 

            20                  25                  30          





Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 

        35                  40                  45              





Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 

    50                  55                  60                  





Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 

65                  70                  75                  80  





Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 

                85                  90                  95      





Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 

            100                 105                 110         





Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 

        115                 120                 125             





Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 

    130                 135                 140                 





Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 

145                 150                 155                 160 





Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 

                165                 170                 175     





Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 

            180                 185                 190         





His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 

        195                 200                 205             





Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 

    210                 215                 220                 





Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 

225                 230                 235                 240 





Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 

                245                 250                 255     





Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 

            260                 265                 270         





Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 

        275                 280                 285             





Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 

    290                 295                 300                 





Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 

305                 310                 315                 320 





Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 

                325                 330                 335     





Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 

            340                 345                 350         





Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 

        355                 360                 365             





Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 

    370                 375                 380                 





Phe Lys Thr Glu Gly Pro Asp Ser Asp 

385                 390             





<210>  70

<211>  341

<212>  PRT

<213>  Homo sapiens



<400>  70



Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 

1               5                   10                  15      





Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 

            20                  25                  30          





Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 

        35                  40                  45              





Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 

    50                  55                  60                  





Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 

65                  70                  75                  80  





Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 

                85                  90                  95      





Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 

            100                 105                 110         





Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 

        115                 120                 125             





Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 

    130                 135                 140                 





Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 

145                 150                 155                 160 





Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 

                165                 170                 175     





Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 

            180                 185                 190         





His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 

        195                 200                 205             





Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 

    210                 215                 220                 





Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 

225                 230                 235                 240 





Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 

                245                 250                 255     





Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 

            260                 265                 270         





Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 

        275                 280                 285             





Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 

    290                 295                 300                 





Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 

305                 310                 315                 320 





Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 

                325                 330                 335     





Gln Lys Glu Asn Cys 

            340     





<210>  71

<211>  346

<212>  PRT

<213>  Homo sapiens



<400>  71



Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 

1               5                   10                  15      





Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 

            20                  25                  30          





Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 

        35                  40                  45              





Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 

    50                  55                  60                  





Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 

65                  70                  75                  80  





Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 

                85                  90                  95      





Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 

            100                 105                 110         





Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 

        115                 120                 125             





Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 

    130                 135                 140                 





Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 

145                 150                 155                 160 





Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 

                165                 170                 175     





Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 

            180                 185                 190         





His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 

        195                 200                 205             





Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 

    210                 215                 220                 





Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 

225                 230                 235                 240 





Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 

                245                 250                 255     





Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 

            260                 265                 270         





Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 

        275                 280                 285             





Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 

    290                 295                 300                 





Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 

305                 310                 315                 320 





Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 

                325                 330                 335     





Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 

            340                 345     





<210>  72

<211>  354

<212>  PRT

<213>  Homo sapiens



<400>  72



Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 

1               5                   10                  15      





Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 

            20                  25                  30          





Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 

        35                  40                  45              





Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 

    50                  55                  60                  





Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 

65                  70                  75                  80  





Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 

                85                  90                  95      





Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 

            100                 105                 110         





Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 

        115                 120                 125             





His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 

    130                 135                 140                 





Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 

145                 150                 155                 160 





Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 

                165                 170                 175     





Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 

            180                 185                 190         





Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 

        195                 200                 205             





Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 

    210                 215                 220                 





Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 

225                 230                 235                 240 





Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 

                245                 250                 255     





His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 

            260                 265                 270         





Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 

        275                 280                 285             





Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 

    290                 295                 300                 





Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 

305                 310                 315                 320 





Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 

                325                 330                 335     





Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 

            340                 345                 350         





Ser Asp 

        





<210>  73

<211>  302

<212>  PRT

<213>  Homo sapiens



<400>  73



Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 

1               5                   10                  15      





Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 

            20                  25                  30          





Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 

        35                  40                  45              





Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 

    50                  55                  60                  





Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 

65                  70                  75                  80  





Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 

                85                  90                  95      





Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 

            100                 105                 110         





Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 

        115                 120                 125             





His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 

    130                 135                 140                 





Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 

145                 150                 155                 160 





Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 

                165                 170                 175     





Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 

            180                 185                 190         





Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 

        195                 200                 205             





Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 

    210                 215                 220                 





Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 

225                 230                 235                 240 





Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 

                245                 250                 255     





His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 

            260                 265                 270         





Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 

        275                 280                 285             





Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 

    290                 295                 300         





<210>  74

<211>  307

<212>  PRT

<213>  Homo sapiens



<400>  74



Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 

1               5                   10                  15      





Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 

            20                  25                  30          





Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 

        35                  40                  45              





Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 

    50                  55                  60                  





Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 

65                  70                  75                  80  





Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 

                85                  90                  95      





Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 

            100                 105                 110         





Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 

        115                 120                 125             





His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 

    130                 135                 140                 





Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 

145                 150                 155                 160 





Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 

                165                 170                 175     





Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 

            180                 185                 190         





Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 

        195                 200                 205             





Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 

    210                 215                 220                 





Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 

225                 230                 235                 240 





Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 

                245                 250                 255     





His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 

            260                 265                 270         





Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 

        275                 280                 285             





Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 

    290                 295                 300                 





Asn Ser Ser 

305         





<210>  75

<211>  261

<212>  PRT

<213>  Homo sapiens



<400>  75



Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 

1               5                   10                  15      





Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 

            20                  25                  30          





Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 

        35                  40                  45              





Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 

    50                  55                  60                  





Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 

65                  70                  75                  80  





Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 

                85                  90                  95      





Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 

            100                 105                 110         





Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 

        115                 120                 125             





Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 

    130                 135                 140                 





Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 

145                 150                 155                 160 





Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 

                165                 170                 175     





Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 

            180                 185                 190         





Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 

        195                 200                 205             





Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 

    210                 215                 220                 





Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 

225                 230                 235                 240 





Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 

                245                 250                 255     





Gly Pro Asp Ser Asp 

            260     





<210>  76

<211>  209

<212>  PRT

<213>  Homo sapiens



<400>  76



Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 

1               5                   10                  15      





Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 

            20                  25                  30          





Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 

        35                  40                  45              





Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 

    50                  55                  60                  





Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 

65                  70                  75                  80  





Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 

                85                  90                  95      





Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 

            100                 105                 110         





Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 

        115                 120                 125             





Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 

    130                 135                 140                 





Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 

145                 150                 155                 160 





Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 

                165                 170                 175     





Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 

            180                 185                 190         





Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 

        195                 200                 205             





Cys 

    





<210>  77

<211>  214

<212>  PRT

<213>  Homo sapiens



<400>  77



Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 

1               5                   10                  15      





Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 

            20                  25                  30          





Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 

        35                  40                  45              





Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 

    50                  55                  60                  





Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 

65                  70                  75                  80  





Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 

                85                  90                  95      





Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 

            100                 105                 110         





Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 

        115                 120                 125             





Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 

    130                 135                 140                 





Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 

145                 150                 155                 160 





Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 

                165                 170                 175     





Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 

            180                 185                 190         





Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 

        195                 200                 205             





Phe Leu Ile Asn Ser Ser 

    210                 





<210>  78

<211>  545

<212>  PRT

<213>  Homo sapiens



<400>  78



Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 

1               5                   10                  15      





Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly 

            20                  25                  30          





Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 

        35                  40                  45              





Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr 

    50                  55                  60                  





Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 

65                  70                  75                  80  





Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 

                85                  90                  95      





Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 

            100                 105                 110         





Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 

        115                 120                 125             





Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 

    130                 135                 140                 





Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 

145                 150                 155                 160 





Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 

                165                 170                 175     





Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 

            180                 185                 190         





Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 

        195                 200                 205             





Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 

    210                 215                 220                 





Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 

225                 230                 235                 240 





Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 

                245                 250                 255     





Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 

            260                 265                 270         





Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 

        275                 280                 285             





Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 

    290                 295                 300                 





Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 

305                 310                 315                 320 





Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 

                325                 330                 335     





Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 

            340                 345                 350         





Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 

        355                 360                 365             





Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 

    370                 375                 380                 





Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 

385                 390                 395                 400 





Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 

                405                 410                 415     





Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 

            420                 425                 430         





Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp 

        435                 440                 445             





Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr 

    450                 455                 460                 





Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly 

465                 470                 475                 480 





Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp 

                485                 490                 495     





Phe Leu Asn Arg Cys Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala 

            500                 505                 510         





Lys Glu Leu Leu Gln His Gln Phe Leu Lys Ile Ala Lys Pro Leu Ser 

        515                 520                 525             





Ser Leu Thr Pro Leu Ile Ala Ala Ala Lys Glu Ala Thr Lys Asn Asn 

    530                 535                 540                 





His 

545 





<210>  79

<211>  553

<212>  PRT

<213>  Homo sapiens



<400>  79



Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro 

1               5                   10                  15      





Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly 

            20                  25                  30          





Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys 

        35                  40                  45              





Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr 

    50                  55                  60                  





Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp 

65                  70                  75                  80  





Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe 

                85                  90                  95      





Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile 

            100                 105                 110         





Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu 

        115                 120                 125             





Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser 

    130                 135                 140                 





Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn 

145                 150                 155                 160 





Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp 

                165                 170                 175     





Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro 

            180                 185                 190         





Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro 

        195                 200                 205             





Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro 

    210                 215                 220                 





Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu 

225                 230                 235                 240 





Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys 

                245                 250                 255     





Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg 

            260                 265                 270         





Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met 

        275                 280                 285             





Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln 

    290                 295                 300                 





Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg 

305                 310                 315                 320 





Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val 

                325                 330                 335     





Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu 

            340                 345                 350         





Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala 

        355                 360                 365             





Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln 

    370                 375                 380                 





Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp 

385                 390                 395                 400 





Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro 

                405                 410                 415     





Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala 

            420                 425                 430         





Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp 

        435                 440                 445             





Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr 

    450                 455                 460                 





Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly 

465                 470                 475                 480 





Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp 

                485                 490                 495     





Phe Leu Asn Arg Cys Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala 

            500                 505                 510         





Lys Glu Leu Leu Gln Val Arg Lys Leu Arg Phe Gln Val Phe Ser Asn 

        515                 520                 525             





Phe Ser Met Ile Ala Ala Ser Ile Pro Glu Asp Cys Gln Ala Pro Leu 

    530                 535                 540                 





Gln Pro His Ser Thr Asp Cys Cys Ser 

545                 550             





<210>  80

<211>  416

<212>  PRT

<213>  Homo sapiens



<400>  80



Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 

1               5                   10                  15      





Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 

            20                  25                  30          





Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 

        35                  40                  45              





Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 

    50                  55                  60                  





Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 

65                  70                  75                  80  





Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 

                85                  90                  95      





Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 

            100                 105                 110         





Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 

        115                 120                 125             





Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 

    130                 135                 140                 





Leu Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys 

145                 150                 155                 160 





Gly His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly 

                165                 170                 175     





Leu Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg 

            180                 185                 190         





Arg Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr 

        195                 200                 205             





Ala Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His 

    210                 215                 220                 





Gly Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln 

225                 230                 235                 240 





Ala Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys 

                245                 250                 255     





Pro Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys 

            260                 265                 270         





Pro Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly 

        275                 280                 285             





Gly Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu 

    290                 295                 300                 





Asp Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln 

305                 310                 315                 320 





Glu Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro 

                325                 330                 335     





Thr Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val 

            340                 345                 350         





Ser Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp 

        355                 360                 365             





Asp Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu 

    370                 375                 380                 





Leu Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met 

385                 390                 395                 400 





Pro Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 

                405                 410                 415     





<210>  81

<211>  266

<212>  PRT

<213>  Homo sapiens



<400>  81



Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 

1               5                   10                  15      





Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 

            20                  25                  30          





Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 

        35                  40                  45              





Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 

    50                  55                  60                  





Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 

65                  70                  75                  80  





Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 

                85                  90                  95      





Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 

            100                 105                 110         





Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 

        115                 120                 125             





Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Glu Gln Lys Asp His 

    130                 135                 140                 





Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 

145                 150                 155                 160 





Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 

                165                 170                 175     





Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 

            180                 185                 190         





Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 

        195                 200                 205             





Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 

    210                 215                 220                 





Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 

225                 230                 235                 240 





Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 

                245                 250                 255     





Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 

            260                 265     





<210>  82

<211>  154

<212>  PRT

<213>  Homo sapiens



<400>  82



Met Asp Glu Ala Asp Arg Arg Leu Leu Arg Arg Cys Arg Leu Arg Leu 

1               5                   10                  15      





Val Glu Glu Leu Gln Val Asp Gln Leu Trp Asp Ala Leu Leu Ser Arg 

            20                  25                  30          





Glu Leu Phe Arg Pro His Met Ile Glu Asp Ile Gln Arg Ala Gly Ser 

        35                  40                  45              





Gly Ser Arg Arg Asp Gln Ala Arg Gln Leu Ile Ile Asp Leu Glu Thr 

    50                  55                  60                  





Arg Gly Ser Gln Ala Leu Pro Leu Phe Ile Ser Cys Leu Glu Asp Thr 

65                  70                  75                  80  





Gly Gln Asp Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala 

                85                  90                  95      





Lys Leu Ser Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg 

            100                 105                 110         





Pro Glu Ile Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro 

        115                 120                 125             





Val Asp Ile Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser 

    130                 135                 140                 





Leu Arg Gly Asn Ala Asp Leu Thr Val Leu 

145                 150                 





<210>  83

<211>  333

<212>  PRT

<213>  Homo sapiens



<400>  83



Met Leu Ala Ser Phe Leu Arg Thr Asn Arg Gln Ala Ala Lys Leu Ser 

1               5                   10                  15      





Lys Pro Thr Leu Glu Asn Leu Thr Pro Val Val Leu Arg Pro Glu Ile 

            20                  25                  30          





Arg Lys Pro Glu Val Leu Arg Pro Glu Thr Pro Arg Pro Val Asp Ile 

        35                  40                  45              





Gly Ser Gly Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly 

    50                  55                  60                  





Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys 

65                  70                  75                  80  





Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr 

                85                  90                  95      





Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser 

            100                 105                 110         





Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys 

        115                 120                 125             





Met Val Leu Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu 

    130                 135                 140                 





Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His 

145                 150                 155                 160 





Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser 

                165                 170                 175     





Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu 

            180                 185                 190         





Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln 

        195                 200                 205             





Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser 

    210                 215                 220                 





Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu 

225                 230                 235                 240 





Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser 

                245                 250                 255     





Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg 

            260                 265                 270         





Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe 

        275                 280                 285             





Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val 

    290                 295                 300                 





Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys 

305                 310                 315                 320 





Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 

                325                 330             





<210>  84

<211>  683

<212>  PRT

<213>  Homo sapiens



<400>  84



Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 

1               5                   10                  15      





Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 

            20                  25                  30          





Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 

        35                  40                  45              





Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 

    50                  55                  60                  





Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 

65                  70                  75                  80  





Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 

                85                  90                  95      





Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 

            100                 105                 110         





Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 

        115                 120                 125             





Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 

    130                 135                 140                 





Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 

145                 150                 155                 160 





Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 

                165                 170                 175     





Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 

            180                 185                 190         





Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 

        195                 200                 205             





Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 

    210                 215                 220                 





Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 

225                 230                 235                 240 





Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 

                245                 250                 255     





Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 

            260                 265                 270         





Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 

        275                 280                 285             





Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 

    290                 295                 300                 





Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 

305                 310                 315                 320 





Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 

                325                 330                 335     





Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 

            340                 345                 350         





Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 

        355                 360                 365             





Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 

    370                 375                 380                 





Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 

385                 390                 395                 400 





Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu 

                405                 410                 415     





Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 

            420                 425                 430         





Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 

        435                 440                 445             





Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 

    450                 455                 460                 





Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 

465                 470                 475                 480 





Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 

                485                 490                 495     





Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 

            500                 505                 510         





Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 

        515                 520                 525             





Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 

    530                 535                 540                 





Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 

545                 550                 555                 560 





Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 

                565                 570                 575     





Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 

            580                 585                 590         





Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 

        595                 600                 605             





Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 

    610                 615                 620                 





Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 

625                 630                 635                 640 





Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 

                645                 650                 655     





Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 

            660                 665                 670         





Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 

        675                 680             





<210>  85

<211>  323

<212>  PRT

<213>  Homo sapiens



<400>  85



Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 

305                 310                 315                 320 





Asn Asp Glu 

            





<210>  86

<211>  292

<212>  PRT

<213>  Homo sapiens



<400>  86



Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val 

    290         





<210>  87

<211>  305

<212>  PRT

<213>  Homo sapiens



<400>  87



Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 

    290                 295                 300                 





Asn 

305 





<210>  88

<211>  311

<212>  PRT

<213>  Homo sapiens



<400>  88



Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn 

305                 310     





<210>  89

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  89



Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 

1               5                   10                  15      





His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 

            20                  25                  30          





Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 

        35                  40                  45              





Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 

    50                  55                  60                  





Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 

65                  70                  75                  80  





Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 

                85                  90                  95      





Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 

            100                 105                 110         





Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 

        115                 120                 125             





Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 

    130                 135                 140                 





Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 

145                 150                 155                 160 





Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 

                165                 170                 175     





Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 

            180                 185                 190         





Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 

        195                 200                 205             





Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 

    210                 215                 220                 





Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 

225                 230                 235 





<210>  90

<211>  198

<212>  PRT

<213>  Homo sapiens



<400>  90



Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 

1               5                   10                  15      





His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 

            20                  25                  30          





Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 

        35                  40                  45              





Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 

    50                  55                  60                  





Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 

65                  70                  75                  80  





Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 

                85                  90                  95      





Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 

            100                 105                 110         





Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 

        115                 120                 125             





Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 

    130                 135                 140                 





Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 

145                 150                 155                 160 





Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Gly Asn Arg Arg Arg 

                165                 170                 175     





Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 

            180                 185                 190         





Leu Ser Ala Arg Tyr Val 

        195             





<210>  91

<211>  276

<212>  PRT

<213>  Homo sapiens



<400>  91



Met Arg Asn Gln Ala Pro Gly Arg Pro Lys Gly Ala Thr Phe Pro Pro 

1               5                   10                  15      





Arg Arg Pro Thr Gly Ser Arg Ala Pro Pro Leu Ala Pro Glu Leu Arg 

            20                  25                  30          





Ala Lys Gln Arg Pro Gly Glu Arg Val Met Ala Leu Pro Val Thr Ala 

        35                  40                  45              





Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ser Gln 

    50                  55                  60                  





Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr Val 

65                  70                  75                  80  





Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys Ser 

                85                  90                  95      





Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu Leu 

            100                 105                 110         





Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr Gln 

        115                 120                 125             





Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu Ser 

    130                 135                 140                 





Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu Ser 

145                 150                 155                 160 





Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala 

                165                 170                 175     





Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 

            180                 185                 190         





Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 

        195                 200                 205             





Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 

    210                 215                 220                 





Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 

225                 230                 235                 240 





Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys 

                245                 250                 255     





Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser 

            260                 265                 270         





Ala Arg Tyr Val 

        275     





<210>  92

<211>  350

<212>  PRT

<213>  Homo sapiens



<400>  92



Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 

1               5                   10                  15      





Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 

            20                  25                  30          





Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 

        35                  40                  45              





Glu Met Phe Arg Glu Val Glu Glu Leu Met Glu Asp Thr Gln His Lys 

    50                  55                  60                  





Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 

65                  70                  75                  80  





Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 

                85                  90                  95      





Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 

            100                 105                 110         





Arg Glu Ile His Lys Ile Thr Asn Asn Gln Thr Gly Gln Met Val Phe 

        115                 120                 125             





Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 

    130                 135                 140                 





His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 

145                 150                 155                 160 





Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 

                165                 170                 175     





Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 

            180                 185                 190         





Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 

        195                 200                 205             





Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 

    210                 215                 220                 





Gly Leu Leu Phe Pro Val Cys Thr Pro Leu Pro Val Glu Gly Glu Leu 

225                 230                 235                 240 





Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 

                245                 250                 255     





Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 

            260                 265                 270         





Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 

        275                 280                 285             





Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 

    290                 295                 300                 





Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 

305                 310                 315                 320 





Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Arg Glu 

                325                 330                 335     





Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 

            340                 345                 350 





<210>  93

<211>  678

<212>  PRT

<213>  Homo sapiens



<400>  93



Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 

1               5                   10                  15      





Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 

            20                  25                  30          





Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 

        35                  40                  45              





Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 

    50                  55                  60                  





Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 

65                  70                  75                  80  





Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 

                85                  90                  95      





Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 

            100                 105                 110         





Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 

        115                 120                 125             





Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 

    130                 135                 140                 





Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 

145                 150                 155                 160 





Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 

                165                 170                 175     





Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 

            180                 185                 190         





Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 

        195                 200                 205             





Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 

    210                 215                 220                 





Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 

225                 230                 235                 240 





Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 

                245                 250                 255     





Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 

            260                 265                 270         





Asp Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val 

        275                 280                 285             





Ala Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr 

    290                 295                 300                 





Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val 

305                 310                 315                 320 





Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe 

                325                 330                 335     





Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala 

            340                 345                 350         





Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr 

        355                 360                 365             





Ser Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val 

    370                 375                 380                 





Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val 

385                 390                 395                 400 





Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu 

                405                 410                 415     





Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp 

            420                 425                 430         





Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp 

        435                 440                 445             





Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val 

    450                 455                 460                 





Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr 

465                 470                 475                 480 





Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro 

                485                 490                 495     





Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His 

            500                 505                 510         





Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro 

        515                 520                 525             





Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser 

    530                 535                 540                 





Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr 

545                 550                 555                 560 





Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val 

                565                 570                 575     





Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly 

            580                 585                 590         





Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu 

        595                 600                 605             





Ala Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly 

    610                 615                 620                 





Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr 

625                 630                 635                 640 





Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp 

                645                 650                 655     





Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro 

            660                 665                 670         





Val Glu Pro Ala Ala Ala 

        675             





<210>  94

<211>  721

<212>  PRT

<213>  Homo sapiens



<400>  94



Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 

1               5                   10                  15      





Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 

            20                  25                  30          





Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 

        35                  40                  45              





Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 

    50                  55                  60                  





Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 

65                  70                  75                  80  





Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 

                85                  90                  95      





Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 

            100                 105                 110         





Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 

        115                 120                 125             





Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 

    130                 135                 140                 





Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 

145                 150                 155                 160 





Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 

                165                 170                 175     





Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 

            180                 185                 190         





Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 

        195                 200                 205             





Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 

    210                 215                 220                 





Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 

225                 230                 235                 240 





Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 

                245                 250                 255     





Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 

            260                 265                 270         





Asp Met Asp Thr Cys Glu Leu Glu Ala Gly Trp Pro Cys Pro Arg His 

        275                 280                 285             





Arg Arg Asp Gly Ser Pro Ala Ala Arg Pro Gly Arg Gly Ala Gln Gly 

    290                 295                 300                 





Ser Arg Ser Glu Gly His Ile Pro Asp Arg Arg Gly Pro Arg Pro Trp 

305                 310                 315                 320 





Gln Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala Lys Ser Val Lys 

                325                 330                 335     





Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile Arg Leu 

            340                 345                 350         





Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala Glu Phe Asp Phe 

        355                 360                 365             





Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala Gly Gly His Gln 

    370                 375                 380                 





Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu 

385                 390                 395                 400 





Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser Ser Gly Pro Val 

                405                 410                 415     





Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu Ala Arg 

            420                 425                 430         





Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met Lys Ile Ala Val 

        435                 440                 445             





Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr His Leu Asn Leu 

    450                 455                 460                 





Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu Val Gln Pro Ile 

465                 470                 475                 480 





Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu Asn Gly 

                485                 490                 495     





Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn Thr Arg Met Gln 

            500                 505                 510         





Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe 

        515                 520                 525             





Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu Asp Val Gly Thr 

    530                 535                 540                 





Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile Arg Pro Ala Ala 

545                 550                 555                 560 





Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp Leu Arg Ala Val 

                565                 570                 575     





Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys Leu Lys 

            580                 585                 590         





Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala Leu Ala Leu Met 

        595                 600                 605             





Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val Thr Val Ser Leu 

    610                 615                 620                 





Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Arg Gly Gln Ser 

625                 630                 635                 640 





Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala Val Leu Glu Arg 

                645                 650                 655     





His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly Leu Pro Asp Val 

            660                 665                 670         





Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys Met Thr 

        675                 680                 685             





Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys 

    690                 695                 700                 





His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val Glu Pro Ala Ala 

705                 710                 715                 720 





Ala 

    





<210>  95

<211>  624

<212>  PRT

<213>  Homo sapiens



<400>  95



Met Cys Met Cys Gln Ala Ser Pro Pro Pro Ala Ala Leu Ala Gly Cys 

1               5                   10                  15      





Leu Leu Ser Ser Cys Val Gln Pro Ala Arg Glu His Gly Gly Ala Phe 

            20                  25                  30          





Ser Lys Ala Glu Trp Leu Ser Asn Cys Ile Asn Lys Tyr Gly Ser Pro 

        35                  40                  45              





Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys Val Gln Asn Leu Pro Asp 

    50                  55                  60                  





Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys Gly Thr Gln Ala Cys Gln 

65                  70                  75                  80  





Asp Leu Met Gly Asn Phe Phe Cys Leu Cys Lys Ala Gly Trp Gly Gly 

                85                  90                  95      





Arg Leu Cys Asp Lys Asp Val Asn Glu Cys Ser Gln Glu Asn Gly Gly 

            100                 105                 110         





Cys Leu Gln Ile Cys His Asn Lys Pro Gly Ser Phe His Cys Ser Cys 

        115                 120                 125             





His Ser Gly Phe Glu Leu Ser Ser Asp Gly Arg Thr Cys Gln Asp Ile 

    130                 135                 140                 





Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly Glu Ala Arg Cys Lys Asn 

145                 150                 155                 160 





Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp Glu Gly Phe Ala Tyr Ser 

                165                 170                 175     





Ser Gln Glu Lys Ala Cys Arg Asp Val Asp Glu Cys Leu Gln Gly Arg 

            180                 185                 190         





Cys Glu Gln Val Cys Val Asn Ser Pro Gly Ser Tyr Thr Cys His Cys 

        195                 200                 205             





Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln Asp Met Asp Thr Cys Glu 

    210                 215                 220                 





Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala Lys Ser Val Lys Ser 

225                 230                 235                 240 





Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile Arg Leu Arg 

                245                 250                 255     





Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala Glu Phe Asp Phe Arg 

            260                 265                 270         





Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala Gly Gly His Gln Asp 

        275                 280                 285             





Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu Gln 

    290                 295                 300                 





Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser Ser Gly Pro Val Ile 

305                 310                 315                 320 





Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu Ala Arg Asn 

                325                 330                 335     





Leu Val Ile Lys Val Asn Arg Asp Ala Val Met Lys Ile Ala Val Ala 

            340                 345                 350         





Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr His Leu Asn Leu Thr 

        355                 360                 365             





Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu Val Gln Pro Ile Asn 

    370                 375                 380                 





Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu Asn Gly Glu 

385                 390                 395                 400 





Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn Thr Arg Met Gln Cys 

                405                 410                 415     





Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe Ala 

            420                 425                 430         





Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu Asp Val Gly Thr Glu 

        435                 440                 445             





Ser Thr Trp Glu Val Glu Val Val Ala His Ile Arg Pro Ala Ala Asp 

    450                 455                 460                 





Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp Leu Arg Ala Val Pro 

465                 470                 475                 480 





Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys Leu Lys Lys 

                485                 490                 495     





Gln Leu Val Val Leu Ala Val Glu His Thr Ala Leu Ala Leu Met Glu 

            500                 505                 510         





Ile Lys Val Cys Asp Gly Gln Glu His Val Val Thr Val Ser Leu Arg 

        515                 520                 525             





Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Arg Gly Gln Ser Glu 

    530                 535                 540                 





Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala Val Leu Glu Arg His 

545                 550                 555                 560 





Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly Leu Pro Asp Val Pro 

                565                 570                 575     





Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys Met Thr Leu 

            580                 585                 590         





Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys His 

        595                 600                 605             





Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val Glu Pro Ala Ala Ala 

    610                 615                 620                 





<210>  96

<211>  405

<212>  PRT

<213>  Homo sapiens



<400>  96



Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala 

1               5                   10                  15      





Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro 

            20                  25                  30          





Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala 

        35                  40                  45              





Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala 

    50                  55                  60                  





Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly 

65                  70                  75                  80  





Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser 

                85                  90                  95      





Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu 

            100                 105                 110         





Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met 

        115                 120                 125             





Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr 

    130                 135                 140                 





His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu 

145                 150                 155                 160 





Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn 

                165                 170                 175     





Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn 

            180                 185                 190         





Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro 

        195                 200                 205             





Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu 

    210                 215                 220                 





Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile 

225                 230                 235                 240 





Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp 

                245                 250                 255     





Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr 

            260                 265                 270         





Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala 

        275                 280                 285             





Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val 

    290                 295                 300                 





Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr 

305                 310                 315                 320 





Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala 

                325                 330                 335     





Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly 

            340                 345                 350         





Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg 

        355                 360                 365             





Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu 

    370                 375                 380                 





Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val 

385                 390                 395                 400 





Glu Pro Ala Ala Ala 

                405 





<210>  97

<211>  379

<212>  PRT

<213>  Homo sapiens



<400>  97



Met Phe Ser Gly Thr Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln 

1               5                   10                  15      





Pro Thr Arg Leu Val Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu 

            20                  25                  30          





Gly Ile Leu Leu Phe Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val 

        35                  40                  45              





Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly 

    50                  55                  60                  





Val Gly Arg Val Thr Ser Ser Gly Pro Val Ile Asn His Gly Met Trp 

65                  70                  75                  80  





Gln Thr Ile Ser Val Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val 

                85                  90                  95      





Asn Arg Asp Ala Val Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln 

            100                 105                 110         





Pro Glu Arg Gly Leu Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro 

        115                 120                 125             





Phe His Glu Lys Asp Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly 

    130                 135                 140                 





Cys Met Arg Ser Trp Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln 

145                 150                 155                 160 





Glu Thr Val Lys Val Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu 

                165                 170                 175     





Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp 

            180                 185                 190         





Tyr Met Arg Thr Pro Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val 

        195                 200                 205             





Glu Val Val Ala His Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe 

    210                 215                 220                 





Ala Leu Trp Ala Pro Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu 

225                 230                 235                 240 





Val Asp Tyr His Ser Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu 

                245                 250                 255     





Ala Val Glu His Thr Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp 

            260                 265                 270         





Gly Gln Glu His Val Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr 

        275                 280                 285             





Leu Glu Val Asp Gly Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln 

    290                 295                 300                 





Leu Gln Glu Arg Leu Ala Val Leu Glu Arg His Leu Arg Ser Pro Val 

305                 310                 315                 320 





Leu Thr Phe Ala Gly Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro 

                325                 330                 335     





Val Thr Ala Phe Tyr Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg 

            340                 345                 350         





Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala 

        355                 360                 365             





His Ser Cys Pro Pro Val Glu Pro Ala Ala Ala 

    370                 375                 





<210>  98

<211>  162

<212>  PRT

<213>  Homo sapiens



<400>  98



Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 

1               5                   10                  15      





Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 

            20                  25                  30          





Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 

        35                  40                  45              





Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 

    50                  55                  60                  





Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 

65                  70                  75                  80  





Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 

                85                  90                  95      





Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 

            100                 105                 110         





Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 

        115                 120                 125             





Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 

    130                 135                 140                 





Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 

145                 150                 155                 160 





Thr Ser 

        





<210>  99

<211>  135

<212>  PRT

<213>  Homo sapiens



<400>  99



Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 

1               5                   10                  15      





Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 

            20                  25                  30          





Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 

        35                  40                  45              





Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 

    50                  55                  60                  





Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 

65                  70                  75                  80  





His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 

                85                  90                  95      





Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 

            100                 105                 110         





Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 

        115                 120                 125             





Gln Met Phe Ile Asn Thr Ser 

    130                 135 





<210>  100

<211>  897

<212>  PRT

<213>  Homo sapiens



<400>  100



Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 

1               5                   10                  15      





Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 

            20                  25                  30          





Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 

        35                  40                  45              





Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 

    50                  55                  60                  





Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 

65                  70                  75                  80  





Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 

                85                  90                  95      





Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 

            100                 105                 110         





Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 

        115                 120                 125             





Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 

    130                 135                 140                 





Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 

145                 150                 155                 160 





Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 

                165                 170                 175     





Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 

            180                 185                 190         





Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 

        195                 200                 205             





Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 

    210                 215                 220                 





Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 

225                 230                 235                 240 





Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 

                245                 250                 255     





Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 

            260                 265                 270         





Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 

        275                 280                 285             





Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 

    290                 295                 300                 





His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 

305                 310                 315                 320 





Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 

                325                 330                 335     





Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 

            340                 345                 350         





Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 

        355                 360                 365             





Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 

    370                 375                 380                 





Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 

385                 390                 395                 400 





Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 

                405                 410                 415     





Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 

            420                 425                 430         





Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 

        435                 440                 445             





Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 

    450                 455                 460                 





Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 

465                 470                 475                 480 





Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 

                485                 490                 495     





Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 

            500                 505                 510         





Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 

        515                 520                 525             





Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 

    530                 535                 540                 





Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 

545                 550                 555                 560 





Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 

                565                 570                 575     





Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 

            580                 585                 590         





Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 

        595                 600                 605             





Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 

    610                 615                 620                 





Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 

625                 630                 635                 640 





Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 

                645                 650                 655     





Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 

            660                 665                 670         





Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 

        675                 680                 685             





Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 

    690                 695                 700                 





Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 

705                 710                 715                 720 





Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 

                725                 730                 735     





Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 

            740                 745                 750         





Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 

        755                 760                 765             





Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 

    770                 775                 780                 





Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 

785                 790                 795                 800 





Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 

                805                 810                 815     





Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 

            820                 825                 830         





Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 

        835                 840                 845             





Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 

    850                 855                 860                 





Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 

865                 870                 875                 880 





Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 

                885                 890                 895     





Cys 

    





<210>  101

<211>  903

<212>  PRT

<213>  Homo sapiens



<400>  101



Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 

1               5                   10                  15      





Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 

            20                  25                  30          





Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 

        35                  40                  45              





Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 

    50                  55                  60                  





Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 

65                  70                  75                  80  





Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 

                85                  90                  95      





Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 

            100                 105                 110         





Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 

        115                 120                 125             





Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 

    130                 135                 140                 





Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 

145                 150                 155                 160 





Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 

                165                 170                 175     





Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 

            180                 185                 190         





Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 

        195                 200                 205             





Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 

    210                 215                 220                 





Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 

225                 230                 235                 240 





Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 

                245                 250                 255     





Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 

            260                 265                 270         





Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Ser Ala Val 

        275                 280                 285             





Leu Leu Arg Glu Glu Glu Cys Ser Pro Val Leu Arg Glu Gly Leu Gly 

    290                 295                 300                 





Ser Leu His Thr Arg His His Cys Gln Ile Pro Val Pro Asp Pro Ala 

305                 310                 315                 320 





Thr His Gly Gln Tyr Ile Val Ser Val Gln Pro Arg Arg Ala Glu Lys 

                325                 330                 335     





His Ile Lys Ser Ser Val Asn Ile Gln Met Ala Pro Pro Ser Leu Asn 

            340                 345                 350         





Val Thr Lys Asp Gly Asp Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys 

        355                 360                 365             





Met Arg Tyr Glu His Ile Asp His Thr Phe Glu Ile Gln Tyr Arg Lys 

    370                 375                 380                 





Asp Thr Ala Thr Trp Lys Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala 

385                 390                 395                 400 





His Ser Met Ala Leu Pro Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala 

                405                 410                 415     





Arg Val Arg Val Arg Thr Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser 

            420                 425                 430         





Glu Trp Ser Glu Ala Arg Ser Trp Asp Thr Glu Ser Val Leu Pro Met 

        435                 440                 445             





Trp Val Leu Ala Leu Ile Val Ile Phe Leu Thr Ile Ala Val Leu Leu 

    450                 455                 460                 





Ala Leu Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp 

465                 470                 475                 480 





Glu Glu Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly 

                485                 490                 495     





Ser Ala Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly 

            500                 505                 510         





Ser Pro Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu 

        515                 520                 525             





Gly Val Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr 

    530                 535                 540                 





Ile Glu Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr 

545                 550                 555                 560 





Thr Pro Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln 

                565                 570                 575     





Pro Gly Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser 

            580                 585                 590         





Phe Asp Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu 

        595                 600                 605             





Pro Asp Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln 

    610                 615                 620                 





Lys Ser Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly 

625                 630                 635                 640 





Gly Gln Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln 

                645                 650                 655     





Ala Val Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro 

            660                 665                 670         





Ser Leu Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg 

        675                 680                 685             





Val Gly Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser 

    690                 695                 700                 





Ser Gly Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser 

705                 710                 715                 720 





Ala Asp Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu 

                725                 730                 735     





Val Pro Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro 

            740                 745                 750         





Gly Leu Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly 

        755                 760                 765             





Phe Glu Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg 

    770                 775                 780                 





Ser Pro Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu 

785                 790                 795                 800 





Asn Pro Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro 

                805                 810                 815     





Glu Gly Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro 

            820                 825                 830         





Gly Leu Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro 

        835                 840                 845             





Gly Pro Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys 

    850                 855                 860                 





Lys Pro Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe 

865                 870                 875                 880 





Lys Ala Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val 

                885                 890                 895     





Asn Lys Pro Gly Glu Val Cys 

            900             





<210>  102

<211>  483

<212>  PRT

<213>  Homo sapiens



<400>  102



Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly 

1               5                   10                  15      





Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg 

            20                  25                  30          





Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly 

        35                  40                  45              





Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr 

    50                  55                  60                  





Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val 

65                  70                  75                  80  





Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys 

                85                  90                  95      





Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu 

            100                 105                 110         





Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln 

        115                 120                 125             





Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile 

    130                 135                 140                 





Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys 

145                 150                 155                 160 





Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys 

                165                 170                 175     





Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu 

            180                 185                 190         





Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val 

        195                 200                 205             





Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu 

    210                 215                 220                 





Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser 

225                 230                 235                 240 





Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met 

                245                 250                 255     





Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn 

            260                 265                 270         





Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu 

        275                 280                 285             





Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys 

    290                 295                 300                 





Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu 

305                 310                 315                 320 





Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala 

                325                 330                 335     





Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys 

            340                 345                 350         





Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala 

        355                 360                 365             





Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu 

    370                 375                 380                 





Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser 

385                 390                 395                 400 





Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr 

                405                 410                 415     





Ser Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser 

            420                 425                 430         





Pro Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly 

        435                 440                 445             





Ser Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys 

    450                 455                 460                 





Lys Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val 

465                 470                 475                 480 





Leu Pro Lys 

            





<210>  103

<211>  511

<212>  PRT

<213>  Homo sapiens



<400>  103



Met Asn Gly Val Ser Trp Ser Gln Asp Leu Gln Glu Gly Ile Ser Ala 

1               5                   10                  15      





Trp Phe Gly Pro Pro Ala Ser Thr Pro Ala Ser Thr Met Ser Ile Arg 

            20                  25                  30          





Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly Pro Arg Ala Phe 

        35                  40                  45              





Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg Ile Ser Ser Ser 

    50                  55                  60                  





Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly Gly Leu Gly Gly 

65                  70                  75                  80  





Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr Ala Val Thr Val 

                85                  90                  95      





Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val Asp Pro Asn Ile 

            100                 105                 110         





Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys Thr Leu Asn Asn 

        115                 120                 125             





Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 

    130                 135                 140                 





Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln Gln Lys Thr Ala 

145                 150                 155                 160 





Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile Asn Asn Leu Arg 

                165                 170                 175     





Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys Leu Glu Ala Glu 

            180                 185                 190         





Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu 

        195                 200                 205             





Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu Phe Val Leu Ile 

    210                 215                 220                 





Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val Glu Leu Glu Ser 

225                 230                 235                 240 





Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu Arg Gln Leu Tyr 

                245                 250                 255     





Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser Asp Thr Ser Val 

            260                 265                 270         





Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met Asp Ser Ile Ile 

        275                 280                 285             





Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn Arg Ser Arg Ala 

    290                 295                 300                 





Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu Leu Gln Ser Leu 

305                 310                 315                 320 





Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys Thr Glu Ile Ser 

                325                 330                 335     





Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu Ile Glu Gly Leu 

            340                 345                 350         





Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala Asp Ala Glu Gln 

        355                 360                 365             





Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys Leu Ser Glu Leu 

    370                 375                 380                 





Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala Arg Gln Leu Arg 

385                 390                 395                 400 





Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Ile Glu Ile 

                405                 410                 415     





Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Leu Glu Ser 

            420                 425                 430         





Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr Ser Gly Tyr Ala 

        435                 440                 445             





Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser Pro Gly Leu Ser 

    450                 455                 460                 





Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly Ser Ser Ser Phe 

465                 470                 475                 480 





Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys Lys Ile Glu Thr 

                485                 490                 495     





Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val Leu Pro Lys 

            500                 505                 510     





<210>  104

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  104



Met Ala Thr Leu Leu Leu Leu Leu Gly Val Leu Val Val Ser Pro Asp 

1               5                   10                  15      





Ala Leu Gly Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro 

            20                  25                  30          





Leu Val Ser Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser 

        35                  40                  45              





Ile Thr Ser Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala 

    50                  55                  60                  





Leu Pro Pro Ser Thr Ser Ile Asn Glu Gly Ser Pro Leu Trp Thr Ser 

65                  70                  75                  80  





Ile Gly Ala Ser Thr Gly Ser Pro Leu Pro Glu Pro Thr Thr Tyr Gln 

                85                  90                  95      





Glu Val Ser Ile Lys Met Ser Ser Val Pro Gln Glu Thr Pro His Ala 

            100                 105                 110         





Thr Ser His Pro Ala Val Pro Ile Thr Ala Asn Ser Leu Gly Ser His 

        115                 120                 125             





Thr Val Thr Gly Gly Thr Ile Thr Thr Asn Ser Pro Glu Thr Ser Ser 

    130                 135                 140                 





Arg Thr Ser Gly Ala Pro Val Thr Thr Ala Ala Ser Ser Leu Glu Thr 

145                 150                 155                 160 





Ser Arg Gly Thr Ser Gly Pro Pro Leu Thr Met Ala Thr Val Ser Leu 

                165                 170                 175     





Glu Thr Ser Lys Gly Thr Ser Gly Pro Pro Val Thr Met Ala Thr Asp 

            180                 185                 190         





Ser Leu Glu Thr Ser Thr Gly Thr Thr Gly Pro Pro Val Thr Met Thr 

        195                 200                 205             





Thr Gly Ser Leu Glu Pro Ser Ser Gly Ala Ser Gly Pro Gln Val Ser 

    210                 215                 220                 





Ser Val Lys Leu Ser Thr Met Met Ser Pro Thr Thr Ser Thr Asn Ala 

225                 230                 235                 240 





Ser Thr Val Pro Phe Arg Asn Pro Asp Glu Asn Ser Arg Gly Met Leu 

                245                 250                 255     





Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val Leu Val Ala 

            260                 265                 270         





Leu Leu Leu Leu Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu 

        275                 280                 285             





Val Leu Ser Arg Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala 

    290                 295                 300                 





Gly Pro Ala Gln Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly 

305                 310                 315                 320 





Gly Ser Gly Gly Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser 

                325                 330                 335     





Ser Arg Arg Pro Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg 

            340                 345                 350         





Gln Gly Ser Leu Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser 

        355                 360                 365             





Leu Lys Gly Glu Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val 

    370                 375                 380                 





Asp Ala Pro Ala Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 

385                 390                 395                 400 





<210>  105

<211>  752

<212>  PRT

<213>  Homo sapiens



<400>  105



Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn Ser Asp 

1               5                   10                  15      





Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly Pro Ser 

            20                  25                  30          





Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser 

        35                  40                  45              





Cys Pro Glu Glu Gln Pro His Val Gly Asn Tyr Arg Leu Leu Arg Thr 

    50                  55                  60                  





Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu 

65                  70                  75                  80  





Thr Gly Arg Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn 

                85                  90                  95      





Pro Ser Ser Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Gly 

            100                 105                 110         





Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu 

        115                 120                 125             





Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu Val Phe 

    130                 135                 140                 





Asp Tyr Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala Arg Ala 

145                 150                 155                 160 





Lys Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Gln Lys Asn 

                165                 170                 175     





Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Glu 

            180                 185                 190         





Ala Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Leu 

        195                 200                 205             





Gly Ser Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro 

    210                 215                 220                 





Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Ile Trp 

225                 230                 235                 240 





Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe 

                245                 250                 255     





Asp Gly His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys 

            260                 265                 270         





Tyr Arg Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser Ile Leu Arg 

        275                 280                 285             





Arg Phe Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu Gln Ile 

    290                 295                 300                 





Met Lys Asp Lys Trp Ile Asn Ile Gly Tyr Glu Gly Glu Glu Leu Lys 

305                 310                 315                 320 





Pro Tyr Thr Glu Pro Glu Glu Asp Phe Gly Asp Thr Lys Arg Ile Glu 

                325                 330                 335     





Val Met Val Gly Met Gly Tyr Thr Arg Glu Glu Ile Lys Glu Ser Leu 

            340                 345                 350         





Thr Ser Gln Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu Leu Gly 

        355                 360                 365             





Arg Lys Thr Glu Glu Gly Gly Asp Arg Gly Ala Pro Gly Leu Ala Leu 

    370                 375                 380                 





Ala Arg Val Arg Ala Pro Ser Asp Thr Thr Asn Gly Thr Ser Ser Ser 

385                 390                 395                 400 





Lys Gly Thr Ser His Ser Lys Gly Gln Arg Ser Ser Ser Ser Thr Tyr 

                405                 410                 415     





His Arg Gln Arg Arg His Ser Asp Phe Cys Gly Pro Ser Pro Ala Pro 

            420                 425                 430         





Leu His Pro Lys Arg Ser Pro Thr Ser Thr Gly Glu Ala Glu Leu Lys 

        435                 440                 445             





Glu Glu Arg Leu Pro Gly Arg Lys Ala Ser Cys Ser Thr Ala Gly Ser 

    450                 455                 460                 





Gly Ser Arg Gly Leu Pro Pro Ser Ser Pro Met Val Ser Ser Ala His 

465                 470                 475                 480 





Asn Pro Asn Lys Ala Glu Ile Pro Glu Arg Arg Lys Asp Ser Thr Ser 

                485                 490                 495     





Thr Pro Asn Asn Leu Pro Pro Ser Met Met Thr Arg Arg Asn Thr Tyr 

            500                 505                 510         





Val Cys Thr Glu Arg Pro Gly Ala Glu Arg Pro Ser Leu Leu Pro Asn 

        515                 520                 525             





Gly Lys Glu Asn Ser Ser Gly Thr Pro Arg Val Pro Pro Ala Ser Pro 

    530                 535                 540                 





Ser Ser His Ser Leu Ala Pro Pro Ser Gly Glu Arg Ser Arg Leu Ala 

545                 550                 555                 560 





Arg Gly Ser Thr Ile Arg Ser Thr Phe His Gly Gly Gln Val Arg Asp 

                565                 570                 575     





Arg Arg Ala Gly Gly Gly Gly Gly Gly Gly Val Gln Asn Gly Pro Pro 

            580                 585                 590         





Ala Ser Pro Thr Leu Ala His Glu Ala Ala Pro Leu Pro Ala Gly Arg 

        595                 600                 605             





Pro Arg Pro Thr Thr Asn Leu Phe Thr Lys Leu Thr Ser Lys Leu Thr 

    610                 615                 620                 





Arg Arg Val Ala Asp Glu Pro Glu Arg Ile Gly Gly Pro Glu Val Thr 

625                 630                 635                 640 





Ser Cys His Leu Pro Trp Asp Gln Thr Glu Thr Ala Pro Arg Leu Leu 

                645                 650                 655     





Arg Phe Pro Trp Ser Val Lys Leu Thr Ser Ser Arg Pro Pro Glu Ala 

            660                 665                 670         





Leu Met Ala Ala Leu Arg Gln Ala Thr Ala Ala Ala Arg Cys Arg Cys 

        675                 680                 685             





Arg Gln Pro Gln Pro Phe Leu Leu Ala Cys Leu His Gly Gly Ala Gly 

    690                 695                 700                 





Gly Pro Glu Pro Leu Ser His Phe Glu Val Glu Val Cys Gln Leu Pro 

705                 710                 715                 720 





Arg Pro Gly Leu Arg Gly Val Leu Phe Arg Arg Val Ala Gly Thr Ala 

                725                 730                 735     





Leu Ala Phe Arg Thr Leu Val Thr Arg Ile Ser Asn Asp Leu Glu Leu 

            740                 745                 750         





<210>  106

<211>  688

<212>  PRT

<213>  Homo sapiens



<400>  106



Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn Ser Asp 

1               5                   10                  15      





Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly Pro Ser 

            20                  25                  30          





Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser 

        35                  40                  45              





Cys Pro Glu Glu Gln Pro His Val Gly Asn Tyr Arg Leu Leu Arg Thr 

    50                  55                  60                  





Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu 

65                  70                  75                  80  





Thr Gly Arg Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn 

                85                  90                  95      





Pro Ser Ser Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Gly 

            100                 105                 110         





Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu 

        115                 120                 125             





Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu Val Phe 

    130                 135                 140                 





Asp Tyr Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala Arg Ala 

145                 150                 155                 160 





Lys Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Gln Lys Asn 

                165                 170                 175     





Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Glu 

            180                 185                 190         





Ala Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Leu 

        195                 200                 205             





Gly Ser Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro 

    210                 215                 220                 





Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Ile Trp 

225                 230                 235                 240 





Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe 

                245                 250                 255     





Asp Gly His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys 

            260                 265                 270         





Tyr Arg Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser Ile Leu Arg 

        275                 280                 285             





Arg Phe Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu Gln Ile 

    290                 295                 300                 





Met Lys Asp Lys Trp Ile Asn Ile Gly Tyr Glu Gly Glu Glu Leu Lys 

305                 310                 315                 320 





Pro Tyr Thr Glu Pro Glu Glu Asp Phe Gly Asp Thr Lys Arg Ile Glu 

                325                 330                 335     





Val Met Val Gly Met Gly Tyr Thr Arg Glu Glu Ile Lys Glu Ser Leu 

            340                 345                 350         





Thr Ser Gln Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu Leu Gly 

        355                 360                 365             





Arg Lys Thr Glu Glu Gly Gly Asp Arg Gly Ala Pro Gly Leu Ala Leu 

    370                 375                 380                 





Ala Arg Val Arg Ala Pro Ser Asp Thr Thr Asn Gly Thr Ser Ser Ser 

385                 390                 395                 400 





Lys Gly Thr Ser His Ser Lys Gly Gln Arg Ser Ser Ser Ser Thr Tyr 

                405                 410                 415     





His Arg Gln Arg Arg His Ser Asp Phe Cys Gly Pro Ser Pro Ala Pro 

            420                 425                 430         





Leu His Pro Lys Arg Ser Pro Thr Ser Thr Gly Glu Ala Glu Leu Lys 

        435                 440                 445             





Glu Glu Arg Leu Pro Gly Arg Lys Ala Ser Cys Ser Thr Ala Gly Ser 

    450                 455                 460                 





Gly Ser Arg Gly Leu Pro Pro Ser Ser Pro Met Val Ser Ser Ala His 

465                 470                 475                 480 





Asn Pro Asn Lys Ala Glu Ile Pro Glu Arg Arg Lys Asp Ser Thr Ser 

                485                 490                 495     





Thr Pro Asn Asn Leu Pro Pro Ser Met Met Thr Arg Arg Asn Thr Tyr 

            500                 505                 510         





Val Cys Thr Glu Arg Pro Gly Ala Glu Arg Pro Ser Leu Leu Pro Asn 

        515                 520                 525             





Gly Lys Glu Asn Ser Ser Gly Thr Pro Arg Val Pro Pro Ala Ser Pro 

    530                 535                 540                 





Ser Ser His Ser Leu Ala Pro Pro Ser Gly Glu Arg Ser Arg Leu Ala 

545                 550                 555                 560 





Arg Gly Ser Thr Ile Arg Ser Thr Phe His Gly Gly Gln Val Arg Asp 

                565                 570                 575     





Arg Arg Ala Gly Gly Gly Gly Gly Gly Gly Val Gln Asn Gly Pro Pro 

            580                 585                 590         





Ala Ser Pro Thr Leu Ala His Glu Ala Ala Pro Leu Pro Ala Gly Arg 

        595                 600                 605             





Pro Arg Pro Thr Thr Asn Leu Phe Thr Lys Leu Thr Ser Lys Leu Thr 

    610                 615                 620                 





Arg Arg Val Thr Leu Asp Pro Ser Lys Arg Gln Asn Ser Asn Arg Cys 

625                 630                 635                 640 





Val Ser Gly Ala Ser Leu Pro Gln Gly Ser Lys Ile Arg Ser Gln Thr 

                645                 650                 655     





Asn Leu Arg Glu Ser Gly Asp Leu Arg Ser Gln Val Ala Ile Tyr Leu 

            660                 665                 670         





Gly Ile Lys Arg Lys Pro Pro Pro Gly Cys Ser Asp Ser Pro Gly Val 

        675                 680                 685             





<210>  107

<211>  600

<212>  PRT

<213>  Homo sapiens



<400>  107



Met Gly Lys Lys Leu Asp Leu Ser Lys Leu Thr Asp Glu Glu Ala Gln 

1               5                   10                  15      





His Val Leu Glu Val Val Gln Arg Asp Phe Asp Leu Arg Arg Lys Glu 

            20                  25                  30          





Glu Glu Arg Leu Glu Ala Leu Lys Gly Lys Ile Lys Lys Glu Ser Ser 

        35                  40                  45              





Lys Arg Glu Leu Leu Ser Asp Thr Ala His Leu Asn Glu Thr His Cys 

    50                  55                  60                  





Ala Arg Cys Leu Gln Pro Tyr Gln Leu Leu Val Asn Ser Lys Arg Gln 

65                  70                  75                  80  





Cys Leu Glu Cys Gly Leu Phe Thr Cys Lys Ser Cys Gly Arg Val His 

                85                  90                  95      





Pro Glu Glu Gln Gly Trp Ile Cys Asp Pro Cys His Leu Ala Arg Val 

            100                 105                 110         





Val Lys Ile Gly Ser Leu Glu Trp Tyr Tyr Glu His Val Lys Ala Arg 

        115                 120                 125             





Phe Lys Arg Phe Gly Ser Ala Lys Val Ile Arg Ser Leu His Gly Arg 

    130                 135                 140                 





Leu Gln Gly Gly Ala Gly Pro Glu Leu Ile Ser Glu Glu Arg Ser Gly 

145                 150                 155                 160 





Asp Ser Asp Gln Thr Asp Glu Asp Gly Glu Pro Gly Ser Glu Ala Gln 

                165                 170                 175     





Ala Gln Ala Gln Pro Phe Gly Ser Lys Lys Lys Arg Leu Leu Ser Val 

            180                 185                 190         





His Asp Phe Asp Phe Glu Gly Asp Ser Asp Asp Ser Thr Gln Pro Gln 

        195                 200                 205             





Gly His Ser Leu His Leu Ser Ser Val Pro Glu Ala Arg Asp Ser Pro 

    210                 215                 220                 





Gln Ser Leu Thr Asp Glu Ser Cys Ser Glu Lys Ala Ala Pro His Lys 

225                 230                 235                 240 





Ala Glu Gly Leu Glu Glu Ala Asp Thr Gly Ala Ser Gly Cys His Ser 

                245                 250                 255     





His Pro Glu Glu Gln Pro Thr Ser Ile Ser Pro Ser Arg His Gly Ala 

            260                 265                 270         





Leu Ala Glu Leu Cys Pro Pro Gly Gly Ser His Arg Met Ala Leu Gly 

        275                 280                 285             





Thr Ala Ala Ala Leu Gly Ser Asn Val Ile Arg Asn Glu Gln Leu Pro 

    290                 295                 300                 





Leu Gln Tyr Leu Ala Asp Val Asp Thr Ser Asp Glu Glu Ser Ile Arg 

305                 310                 315                 320 





Ala His Val Met Ala Ser His His Ser Lys Arg Arg Gly Arg Ala Ser 

                325                 330                 335     





Ser Glu Ser Gln Ile Phe Glu Leu Asn Lys His Ile Ser Ala Val Glu 

            340                 345                 350         





Cys Leu Leu Thr Tyr Leu Glu Asn Thr Val Val Pro Pro Leu Ala Lys 

        355                 360                 365             





Gly Leu Gly Ala Gly Val Arg Thr Glu Ala Asp Val Glu Glu Glu Ala 

    370                 375                 380                 





Leu Arg Arg Lys Leu Glu Glu Leu Thr Ser Asn Val Ser Asp Gln Glu 

385                 390                 395                 400 





Thr Ser Ser Glu Glu Glu Glu Ala Lys Asp Glu Lys Ala Glu Pro Asn 

                405                 410                 415     





Arg Asp Lys Ser Val Gly Pro Leu Pro Gln Ala Asp Pro Glu Val Gly 

            420                 425                 430         





Thr Ala Ala His Gln Thr Asn Arg Gln Glu Lys Ser Pro Gln Asp Pro 

        435                 440                 445             





Gly Asp Pro Val Gln Tyr Asn Arg Thr Thr Asp Glu Glu Leu Ser Glu 

    450                 455                 460                 





Leu Glu Asp Arg Val Ala Val Thr Ala Ser Glu Val Gln Gln Ala Glu 

465                 470                 475                 480 





Ser Glu Val Ser Asp Ile Glu Ser Arg Ile Ala Ala Leu Arg Ala Ala 

                485                 490                 495     





Gly Leu Thr Val Lys Pro Ser Gly Lys Pro Arg Arg Lys Ser Asn Leu 

            500                 505                 510         





Pro Ile Phe Leu Pro Arg Val Ala Gly Lys Leu Gly Lys Arg Pro Glu 

        515                 520                 525             





Asp Pro Asn Ala Asp Pro Ser Ser Glu Ala Lys Ala Met Ala Val Pro 

    530                 535                 540                 





Tyr Leu Leu Arg Arg Lys Phe Ser Asn Ser Leu Lys Ser Gln Gly Lys 

545                 550                 555                 560 





Asp Asp Asp Ser Phe Asp Arg Lys Ser Val Tyr Arg Gly Ser Leu Thr 

                565                 570                 575     





Gln Arg Asn Pro Asn Ala Arg Lys Gly Met Ala Ser His Thr Phe Ala 

            580                 585                 590         





Lys Pro Val Val Ala His Gln Ser 

        595                 600 





<210>  108

<211>  572

<212>  PRT

<213>  Homo sapiens



<400>  108



Met Gly Lys Lys Leu Asp Leu Ser Lys Leu Thr Asp Glu Glu Ala Gln 

1               5                   10                  15      





His Val Leu Glu Val Val Gln Arg Asp Phe Asp Leu Arg Arg Lys Glu 

            20                  25                  30          





Glu Glu Arg Leu Glu Ala Leu Lys Gly Lys Ile Lys Lys Glu Ser Ser 

        35                  40                  45              





Lys Arg Glu Leu Leu Ser Asp Thr Ala His Leu Asn Glu Thr His Cys 

    50                  55                  60                  





Ala Arg Cys Leu Gln Pro Tyr Gln Leu Leu Val Asn Ser Lys Arg Gln 

65                  70                  75                  80  





Cys Leu Glu Cys Gly Leu Phe Thr Cys Lys Ser Cys Gly Arg Val His 

                85                  90                  95      





Pro Glu Glu Gln Gly Trp Ile Cys Asp Pro Cys His Leu Ala Arg Val 

            100                 105                 110         





Val Lys Ile Gly Ser Leu Glu Trp Tyr Tyr Glu His Val Lys Ala Arg 

        115                 120                 125             





Phe Lys Arg Phe Gly Ser Ala Lys Val Ile Arg Ser Leu His Gly Arg 

    130                 135                 140                 





Leu Gln Gly Gly Ala Gly Pro Glu Leu Ile Ser Glu Glu Arg Ser Gly 

145                 150                 155                 160 





Asp Ser Asp Gln Thr Asp Glu Asp Gly Glu Pro Gly Ser Glu Ala Gln 

                165                 170                 175     





Ala Gln Ala Gln Pro Phe Gly Ser Lys Lys Lys Arg Leu Leu Ser Val 

            180                 185                 190         





His Asp Phe Asp Phe Glu Gly Asp Ser Asp Asp Ser Thr Gln Pro Gln 

        195                 200                 205             





Gly His Ser Leu His Leu Ser Ser Val Pro Glu Ala Arg Asp Ser Pro 

    210                 215                 220                 





Gln Ser Leu Thr Asp Glu Ser Cys Ser Glu Lys Ala Ala Pro His Lys 

225                 230                 235                 240 





Ala Glu Gly Leu Glu Glu Ala Asp Thr Gly Ala Ser Gly Cys His Ser 

                245                 250                 255     





His Pro Glu Glu Gln Pro Thr Ser Ile Ser Pro Ser Arg His Gly Ala 

            260                 265                 270         





Leu Ala Glu Leu Cys Pro Pro Gly Gly Ser His Arg Met Ala Leu Gly 

        275                 280                 285             





Thr Ala Ala Ala Leu Gly Ser Asn Val Ile Arg Asn Glu Gln Leu Pro 

    290                 295                 300                 





Leu Gln Tyr Leu Ala Asp Val Asp Thr Ser Asp Glu Glu Ser Ile Arg 

305                 310                 315                 320 





Ala His Val Met Ala Ser His His Ser Lys Arg Arg Gly Arg Ala Ser 

                325                 330                 335     





Ser Glu Ser Gln Gly Leu Gly Ala Gly Val Arg Thr Glu Ala Asp Val 

            340                 345                 350         





Glu Glu Glu Ala Leu Arg Arg Lys Leu Glu Glu Leu Thr Ser Asn Val 

        355                 360                 365             





Ser Asp Gln Glu Thr Ser Ser Glu Glu Glu Glu Ala Lys Asp Glu Lys 

    370                 375                 380                 





Ala Glu Pro Asn Arg Asp Lys Ser Val Gly Pro Leu Pro Gln Ala Asp 

385                 390                 395                 400 





Pro Glu Val Gly Thr Ala Ala His Gln Thr Asn Arg Gln Glu Lys Ser 

                405                 410                 415     





Pro Gln Asp Pro Gly Asp Pro Val Gln Tyr Asn Arg Thr Thr Asp Glu 

            420                 425                 430         





Glu Leu Ser Glu Leu Glu Asp Arg Val Ala Val Thr Ala Ser Glu Val 

        435                 440                 445             





Gln Gln Ala Glu Ser Glu Val Ser Asp Ile Glu Ser Arg Ile Ala Ala 

    450                 455                 460                 





Leu Arg Ala Ala Gly Leu Thr Val Lys Pro Ser Gly Lys Pro Arg Arg 

465                 470                 475                 480 





Lys Ser Asn Leu Pro Ile Phe Leu Pro Arg Val Ala Gly Lys Leu Gly 

                485                 490                 495     





Lys Arg Pro Glu Asp Pro Asn Ala Asp Pro Ser Ser Glu Ala Lys Ala 

            500                 505                 510         





Met Ala Val Pro Tyr Leu Leu Arg Arg Lys Phe Ser Asn Ser Leu Lys 

        515                 520                 525             





Ser Gln Gly Lys Asp Asp Asp Ser Phe Asp Arg Lys Ser Val Tyr Arg 

    530                 535                 540                 





Gly Ser Leu Thr Gln Arg Asn Pro Asn Ala Arg Lys Gly Met Ala Ser 

545                 550                 555                 560 





His Thr Phe Ala Lys Pro Val Val Ala His Gln Ser 

                565                 570         





<210>  109

<211>  480

<212>  PRT

<213>  Hom sapiens



<400>  109



Met Gly Lys Lys Leu Asp Leu Ser Lys Leu Thr Asp Glu Glu Ala Gln 

1               5                   10                  15      





His Val Leu Glu Val Val Gln Arg Asp Phe Asp Leu Arg Arg Lys Glu 

            20                  25                  30          





Glu Glu Arg Leu Glu Ala Leu Lys Gly Lys Ile Lys Lys Glu Ser Ser 

        35                  40                  45              





Lys Arg Glu Leu Leu Ser Asp Thr Ala His Leu Asn Glu Thr His Cys 

    50                  55                  60                  





Ala Arg Cys Leu Gln Pro Tyr Gln Leu Leu Val Asn Ser Lys Arg Gln 

65                  70                  75                  80  





Cys Leu Glu Cys Gly Leu Phe Thr Cys Lys Ser Cys Gly Arg Val His 

                85                  90                  95      





Pro Glu Glu Gln Gly Trp Ile Cys Asp Pro Cys His Leu Ala Arg Val 

            100                 105                 110         





Val Lys Ile Gly Ser Leu Glu Trp Tyr Tyr Glu His Val Lys Ala Arg 

        115                 120                 125             





Phe Lys Arg Phe Gly Ser Ala Lys Val Ile Arg Ser Leu His Gly Arg 

    130                 135                 140                 





Leu Gln Gly Gly Ala Gly Pro Glu Leu Ile Ser Glu Glu Arg Ser Gly 

145                 150                 155                 160 





Asp Ser Asp Gln Thr Asp Glu Asp Gly Glu Pro Gly Ser Glu Ala Gln 

                165                 170                 175     





Ala Gln Ala Gln Pro Phe Gly Ser Lys Ser Leu Thr Asp Glu Ser Cys 

            180                 185                 190         





Ser Glu Lys Ala Ala Pro His Lys Ala Glu Gly Leu Glu Glu Ala Asp 

        195                 200                 205             





Thr Gly Ala Ser Gly Cys His Ser His Pro Glu Glu Gln Pro Thr Ser 

    210                 215                 220                 





Ile Ser Pro Ser Arg His Gly Ala Leu Ala Glu Leu Cys Pro Pro Gly 

225                 230                 235                 240 





Gly Ser His Arg Met Ala Leu Gly Thr Ala Ala Ala Leu Gly Ser Asn 

                245                 250                 255     





Val Ile Arg Asn Glu Gln Leu Pro Leu Gln Tyr Leu Ala Asp Val Asp 

            260                 265                 270         





Thr Ser Asp Glu Glu Ser Ile Arg Ala His Val Met Ala Ser His His 

        275                 280                 285             





Ser Lys Arg Arg Gly Arg Ala Ser Ser Glu Ser Gln Gly Leu Gly Ala 

    290                 295                 300                 





Gly Val Arg Thr Glu Ala Asp Val Glu Glu Glu Ala Leu Arg Arg Lys 

305                 310                 315                 320 





Leu Glu Glu Leu Thr Ser Asn Val Ser Asp Gln Glu Thr Ser Ser Glu 

                325                 330                 335     





Glu Glu Glu Ala Lys Asp Glu Lys Ala Glu Pro Asn Arg Asp Lys Ser 

            340                 345                 350         





Val Gly Pro Leu Pro Gln Ala Asp Pro Glu Val Ser Asp Ile Glu Ser 

        355                 360                 365             





Arg Ile Ala Ala Leu Arg Ala Ala Gly Leu Thr Val Lys Pro Ser Gly 

    370                 375                 380                 





Lys Pro Arg Arg Lys Ser Asn Leu Pro Ile Phe Leu Pro Arg Val Ala 

385                 390                 395                 400 





Gly Lys Leu Gly Lys Arg Pro Glu Asp Pro Asn Ala Asp Pro Ser Ser 

                405                 410                 415     





Glu Ala Lys Ala Met Ala Val Pro Tyr Leu Leu Arg Arg Lys Phe Ser 

            420                 425                 430         





Asn Ser Leu Lys Ser Gln Gly Lys Asp Asp Asp Ser Phe Asp Arg Lys 

        435                 440                 445             





Ser Val Tyr Arg Gly Ser Leu Thr Gln Arg Asn Pro Asn Ala Arg Lys 

    450                 455                 460                 





Gly Met Ala Ser His Thr Phe Ala Lys Pro Val Val Ala His Gln Ser 

465                 470                 475                 480 





<210>  110

<211>  551

<212>  PRT

<213>  Homo sapiens



<400>  110



Met Gly Lys Lys Leu Asp Leu Ser Lys Leu Thr Asp Glu Glu Ala Gln 

1               5                   10                  15      





His Val Leu Glu Val Val Gln Arg Asp Phe Asp Leu Arg Arg Lys Glu 

            20                  25                  30          





Glu Glu Arg Leu Glu Ala Leu Lys Gly Lys Ile Lys Lys Glu Ser Ser 

        35                  40                  45              





Lys Arg Glu Leu Leu Ser Asp Thr Ala His Leu Asn Glu Thr His Cys 

    50                  55                  60                  





Ala Arg Cys Leu Gln Pro Tyr Gln Leu Leu Val Asn Ser Lys Arg Gln 

65                  70                  75                  80  





Cys Leu Glu Cys Gly Leu Phe Thr Cys Lys Ser Cys Gly Arg Val His 

                85                  90                  95      





Pro Glu Glu Gln Gly Trp Ile Cys Asp Pro Cys His Leu Ala Arg Val 

            100                 105                 110         





Val Lys Ile Gly Ser Leu Glu Trp Tyr Tyr Glu His Val Lys Ala Arg 

        115                 120                 125             





Phe Lys Arg Phe Gly Ser Ala Lys Val Ile Arg Ser Leu His Gly Arg 

    130                 135                 140                 





Leu Gln Gly Gly Ala Gly Pro Glu Leu Ile Ser Glu Glu Arg Ser Gly 

145                 150                 155                 160 





Asp Ser Asp Gln Thr Asp Glu Asp Gly Glu Pro Gly Ser Glu Ala Gln 

                165                 170                 175     





Ala Gln Ala Gln Pro Phe Gly Ser Lys Lys Lys Arg Leu Leu Ser Val 

            180                 185                 190         





His Asp Phe Asp Phe Glu Gly Asp Ser Asp Asp Ser Thr Gln Pro Gln 

        195                 200                 205             





Gly His Ser Leu His Leu Ser Ser Val Pro Glu Ala Arg Asp Ser Pro 

    210                 215                 220                 





Gln Ser Leu Thr Asp Glu Ser Cys Ser Glu Lys Ala Ala Pro His Lys 

225                 230                 235                 240 





Ala Glu Gly Leu Glu Glu Ala Asp Thr Gly Ala Ser Gly Cys His Ser 

                245                 250                 255     





His Pro Glu Glu Gln Pro Thr Ser Ile Ser Pro Ser Arg His Gly Ala 

            260                 265                 270         





Leu Ala Glu Leu Cys Pro Pro Gly Gly Ser His Arg Met Ala Leu Gly 

        275                 280                 285             





Thr Ala Ala Ala Leu Gly Ser Asn Val Ile Arg Asn Glu Gln Leu Pro 

    290                 295                 300                 





Leu Gln Tyr Leu Ala Asp Val Asp Thr Ser Asp Glu Glu Ser Ile Arg 

305                 310                 315                 320 





Ala His Val Met Ala Ser His His Ser Lys Arg Arg Gly Arg Ala Ser 

                325                 330                 335     





Ser Glu Ser Gln Ile Phe Glu Leu Asn Lys His Ile Ser Ala Val Glu 

            340                 345                 350         





Cys Leu Leu Thr Tyr Leu Glu Asn Thr Val Val Pro Pro Leu Ala Lys 

        355                 360                 365             





Gly Leu Gly Ala Gly Val Arg Thr Glu Ala Asp Val Glu Glu Glu Ala 

    370                 375                 380                 





Leu Arg Arg Lys Leu Glu Glu Leu Thr Ser Asn Val Ser Asp Gln Glu 

385                 390                 395                 400 





Thr Ser Ser Glu Glu Glu Glu Ala Lys Asp Glu Lys Ala Glu Pro Asn 

                405                 410                 415     





Arg Asp Lys Ser Val Gly Pro Leu Pro Gln Ala Asp Pro Glu Val Gly 

            420                 425                 430         





Thr Ala Ala His Gln Thr Asn Arg Gln Glu Lys Ser Pro Gln Asp Pro 

        435                 440                 445             





Gly Asp Pro Val Gln Tyr Asn Arg Thr Thr Asp Glu Glu Leu Ser Glu 

    450                 455                 460                 





Leu Glu Asp Arg Val Ala Val Thr Ala Ser Glu Val Gln Gln Ala Glu 

465                 470                 475                 480 





Ser Glu Val Ser Asp Ile Glu Ser Arg Ile Ala Ala Leu Arg Ala Ala 

                485                 490                 495     





Gly Leu Thr Val Lys Pro Ser Gly Lys Pro Arg Arg Lys Ser Asn Leu 

            500                 505                 510         





Pro Ala Leu Tyr Glu Gly Thr Leu Ser Leu Cys Ser Glu Asp Leu Lys 

        515                 520                 525             





His Thr His Pro Asp Ser Val Lys Ser Lys Arg Ser Arg Leu Asn His 

    530                 535                 540                 





Val Ala Ser Cys Gly Asn Pro 

545                 550     





<210>  111

<211>  457

<212>  PRT

<213>  Homo sapiens



<400>  111



Met Gly Lys Lys Leu Asp Leu Ser Lys Leu Thr Asp Glu Glu Ala Gln 

1               5                   10                  15      





His Val Leu Glu Val Val Gln Arg Asp Phe Asp Leu Arg Arg Lys Glu 

            20                  25                  30          





Glu Glu Arg Leu Glu Ala Leu Lys Gly Lys Ile Lys Lys Glu Ser Ser 

        35                  40                  45              





Lys Arg Glu Leu Leu Ser Asp Thr Ala His Leu Asn Glu Thr His Cys 

    50                  55                  60                  





Ala Arg Cys Leu Gln Pro Tyr Gln Leu Leu Val Asn Ser Lys Arg Gln 

65                  70                  75                  80  





Cys Leu Glu Cys Gly Leu Phe Thr Cys Lys Ser Cys Gly Arg Val His 

                85                  90                  95      





Pro Glu Glu Gln Gly Trp Ile Cys Asp Pro Cys His Leu Ala Arg Val 

            100                 105                 110         





Val Lys Ile Gly Ser Leu Glu Trp Tyr Tyr Glu His Val Lys Ala Arg 

        115                 120                 125             





Phe Lys Arg Phe Gly Ser Ala Lys Val Ile Arg Ser Leu His Gly Arg 

    130                 135                 140                 





Leu Gln Gly Gly Ala Gly Pro Glu Leu Ile Ser Glu Glu Arg Ser Gly 

145                 150                 155                 160 





Asp Ser Asp Gln Thr Asp Glu Asp Gly Glu Pro Gly Ser Glu Ala Gln 

                165                 170                 175     





Ala Gln Ala Gln Pro Phe Gly Ser Lys Lys Lys Arg Leu Leu Ser Val 

            180                 185                 190         





His Asp Phe Asp Phe Glu Gly Asp Ser Asp Asp Ser Thr Gln Pro Gln 

        195                 200                 205             





Gly His Ser Leu His Leu Ser Ser Val Pro Glu Ala Arg Asp Ser Pro 

    210                 215                 220                 





Gln Gly Leu Gly Ala Gly Val Arg Thr Glu Ala Asp Val Glu Glu Glu 

225                 230                 235                 240 





Ala Leu Arg Arg Lys Leu Glu Glu Leu Thr Ser Asn Val Ser Asp Gln 

                245                 250                 255     





Glu Thr Ser Ser Glu Glu Glu Glu Ala Lys Asp Glu Lys Ala Glu Pro 

            260                 265                 270         





Asn Arg Asp Lys Ser Val Gly Pro Leu Pro Gln Ala Asp Pro Glu Val 

        275                 280                 285             





Gly Thr Ala Ala His Gln Thr Asn Arg Gln Glu Lys Ser Pro Gln Asp 

    290                 295                 300                 





Pro Gly Asp Pro Val Gln Tyr Asn Arg Thr Thr Asp Glu Glu Leu Ser 

305                 310                 315                 320 





Glu Leu Glu Asp Arg Val Ala Val Thr Ala Ser Glu Val Gln Gln Ala 

                325                 330                 335     





Glu Ser Glu Val Ser Asp Ile Glu Ser Arg Ile Ala Ala Leu Arg Ala 

            340                 345                 350         





Ala Gly Leu Thr Val Lys Pro Ser Gly Lys Pro Arg Arg Lys Ser Asn 

        355                 360                 365             





Leu Pro Ile Phe Leu Pro Arg Val Ala Gly Lys Leu Gly Lys Arg Pro 

    370                 375                 380                 





Glu Asp Pro Asn Ala Asp Pro Ser Ser Glu Ala Lys Ala Met Ala Val 

385                 390                 395                 400 





Pro Tyr Leu Leu Arg Arg Lys Phe Ser Asn Ser Leu Lys Ser Gln Gly 

                405                 410                 415     





Lys Asp Asp Asp Ser Phe Asp Arg Lys Ser Val Tyr Arg Gly Ser Leu 

            420                 425                 430         





Thr Gln Arg Asn Pro Asn Ala Arg Lys Gly Met Ala Ser His Thr Phe 

        435                 440                 445             





Ala Lys Pro Val Val Ala His Gln Ser 

    450                 455         





<210>  112

<211>  469

<212>  PRT

<213>  Homo sapiens



<400>  112



Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 

1               5                   10                  15      





Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 

            20                  25                  30          





Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 

        35                  40                  45              





Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 

    50                  55                  60                  





Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 

65                  70                  75                  80  





Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 

                85                  90                  95      





Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 

            100                 105                 110         





His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 

        115                 120                 125             





Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 

    130                 135                 140                 





Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 

145                 150                 155                 160 





Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 

                165                 170                 175     





Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 

            180                 185                 190         





Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 

        195                 200                 205             





Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 

    210                 215                 220                 





Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 

225                 230                 235                 240 





Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 

                245                 250                 255     





Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 

            260                 265                 270         





Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 

        275                 280                 285             





Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 

    290                 295                 300                 





Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 

305                 310                 315                 320 





Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 

                325                 330                 335     





Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 

            340                 345                 350         





Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 

        355                 360                 365             





Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 

    370                 375                 380                 





Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 

385                 390                 395                 400 





Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 

                405                 410                 415     





His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 

            420                 425                 430         





Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 

        435                 440                 445             





Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 

    450                 455                 460                 





Asn Cys Arg Lys Asn 

465                 





<210>  113

<211>  267

<212>  PRT

<213>  Homo sapiens



<400>  113



Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu 

1               5                   10                  15      





Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp 

            20                  25                  30          





Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu 

        35                  40                  45              





Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys 

    50                  55                  60                  





Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu 

65                  70                  75                  80  





Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser 

                85                  90                  95      





Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg 

            100                 105                 110         





Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu 

        115                 120                 125             





Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe 

    130                 135                 140                 





Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg 

145                 150                 155                 160 





Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu 

                165                 170                 175     





Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe 

            180                 185                 190         





Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe 

        195                 200                 205             





Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His 

    210                 215                 220                 





Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp 

225                 230                 235                 240 





Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys 

                245                 250                 255     





Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys 

            260                 265         





<210>  114

<211>  599

<212>  PRT

<213>  Homo sapiens



<400>  114



Met Ser Arg Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu 

1               5                   10                  15      





Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 

            20                  25                  30          





Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 

        35                  40                  45              





Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 

    50                  55                  60                  





Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 

65                  70                  75                  80  





Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 

                85                  90                  95      





Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 

            100                 105                 110         





Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 

        115                 120                 125             





Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 

    130                 135                 140                 





Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 

145                 150                 155                 160 





Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 

                165                 170                 175     





Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 

            180                 185                 190         





Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 

        195                 200                 205             





Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 

    210                 215                 220                 





His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 

225                 230                 235                 240 





Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 

                245                 250                 255     





Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 

            260                 265                 270         





His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 

        275                 280                 285             





Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 

    290                 295                 300                 





Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 

305                 310                 315                 320 





Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 

                325                 330                 335     





Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 

            340                 345                 350         





Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 

        355                 360                 365             





Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 

    370                 375                 380                 





His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu 

385                 390                 395                 400 





Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr 

                405                 410                 415     





Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg 

            420                 425                 430         





Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val 

        435                 440                 445             





Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu 

    450                 455                 460                 





Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu 

465                 470                 475                 480 





Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp 

                485                 490                 495     





Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His 

            500                 505                 510         





Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe 

        515                 520                 525             





Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp 

    530                 535                 540                 





Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr 

545                 550                 555                 560 





Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr 

                565                 570                 575     





Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val 

            580                 585                 590         





Glu Arg Pro Ser Thr Glu Leu 

        595                 





<210>  115

<211>  562

<212>  PRT

<213>  Homo sapiens



<400>  115



Met Ser Arg Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu 

1               5                   10                  15      





Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 

            20                  25                  30          





Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 

        35                  40                  45              





Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 

    50                  55                  60                  





Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 

65                  70                  75                  80  





Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 

                85                  90                  95      





Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 

            100                 105                 110         





Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 

        115                 120                 125             





Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 

    130                 135                 140                 





Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 

145                 150                 155                 160 





Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 

                165                 170                 175     





Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 

            180                 185                 190         





Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 

        195                 200                 205             





Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 

    210                 215                 220                 





His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 

225                 230                 235                 240 





Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 

                245                 250                 255     





Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 

            260                 265                 270         





His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 

        275                 280                 285             





Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 

    290                 295                 300                 





Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 

305                 310                 315                 320 





Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 

                325                 330                 335     





Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 

            340                 345                 350         





Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 

        355                 360                 365             





Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 

    370                 375                 380                 





His Trp His Pro Leu Met Pro Asp Ser Phe Lys Ile Gly Gly Gly Arg 

385                 390                 395                 400 





Asn Met Asp His His Ile Leu His Val Ala Val Asp Val Ile Arg Glu 

                405                 410                 415     





Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu Tyr Arg Lys Arg Phe 

            420                 425                 430         





Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu Val Gly Glu Lys Glu 

        435                 440                 445             





Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp Ile Asp Ala Leu Glu 

    450                 455                 460                 





Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His Pro Asn Ser Ile Phe 

465                 470                 475                 480 





Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe Ser Leu Lys Gly Leu 

                485                 490                 495     





Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp Lys Pro Ser Thr Phe 

            500                 505                 510         





Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr Ala Thr Leu Lys Lys 

        515                 520                 525             





Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr Val Ser Phe Arg Val 

    530                 535                 540                 





Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val Glu Arg Pro Ser Thr 

545                 550                 555                 560 





Glu Leu 

        





<210>  116

<211>  537

<212>  PRT

<213>  Homo sapiens



<400>  116



Met Arg Lys Pro Arg Leu Met Asn Pro Cys Cys Tyr Tyr Pro Cys Gln 

1               5                   10                  15      





His Gln Gly Ile Cys Val Arg Phe Gly Leu Asp Arg Tyr Gln Cys Asp 

            20                  25                  30          





Cys Thr Arg Thr Gly Tyr Ser Gly Pro Asn Cys Thr Ile Pro Gly Leu 

        35                  40                  45              





Trp Thr Trp Leu Arg Asn Ser Leu Arg Pro Ser Pro Ser Phe Thr His 

    50                  55                  60                  





Phe Leu Leu Thr His Gly Arg Trp Phe Trp Glu Phe Val Asn Ala Thr 

65                  70                  75                  80  





Phe Ile Arg Glu Met Leu Met Arg Leu Val Leu Thr Val Arg Ser Asn 

                85                  90                  95      





Leu Ile Pro Ser Pro Pro Thr Tyr Asn Ser Ala His Asp Tyr Ile Ser 

            100                 105                 110         





Trp Glu Ser Phe Ser Asn Val Ser Tyr Tyr Thr Arg Ile Leu Pro Ser 

        115                 120                 125             





Val Pro Lys Asp Cys Pro Thr Pro Met Gly Thr Lys Gly Lys Lys Gln 

    130                 135                 140                 





Leu Pro Asp Ala Gln Leu Leu Ala Arg Arg Phe Leu Leu Arg Arg Lys 

145                 150                 155                 160 





Phe Ile Pro Asp Pro Gln Gly Thr Asn Leu Met Phe Ala Phe Phe Ala 

                165                 170                 175     





Gln His Phe Thr His Gln Phe Phe Lys Thr Ser Gly Lys Met Gly Pro 

            180                 185                 190         





Gly Phe Thr Lys Ala Leu Gly His Gly Val Asp Leu Gly His Ile Tyr 

        195                 200                 205             





Gly Asp Asn Leu Glu Arg Gln Tyr Gln Leu Arg Leu Phe Lys Asp Gly 

    210                 215                 220                 





Lys Leu Lys Tyr Gln Val Leu Asp Gly Glu Met Tyr Pro Pro Ser Val 

225                 230                 235                 240 





Glu Glu Ala Pro Val Leu Met His Tyr Pro Arg Gly Ile Pro Pro Gln 

                245                 250                 255     





Ser Gln Met Ala Val Gly Gln Glu Val Phe Gly Leu Leu Pro Gly Leu 

            260                 265                 270         





Met Leu Tyr Ala Thr Leu Trp Leu Arg Glu His Asn Arg Val Cys Asp 

        275                 280                 285             





Leu Leu Lys Ala Glu His Pro Thr Trp Gly Asp Glu Gln Leu Phe Gln 

    290                 295                 300                 





Thr Thr Arg Leu Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu 

305                 310                 315                 320 





Glu Tyr Val Gln Gln Leu Ser Gly Tyr Phe Leu Gln Leu Lys Phe Asp 

                325                 330                 335     





Pro Glu Leu Leu Phe Gly Val Gln Phe Gln Tyr Arg Asn Arg Ile Ala 

            340                 345                 350         





Met Glu Phe Asn His Leu Tyr His Trp His Pro Leu Met Pro Asp Ser 

        355                 360                 365             





Phe Lys Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val 

    370                 375                 380                 





Ala Val Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe 

385                 390                 395                 400 





Asn Glu Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln 

                405                 410                 415     





Glu Leu Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr 

            420                 425                 430         





Gly Asp Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys 

        435                 440                 445             





Cys His Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala 

    450                 455                 460                 





Pro Phe Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu 

465                 470                 475                 480 





Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val 

                485                 490                 495     





Lys Thr Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys 

            500                 505                 510         





Pro Tyr Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro 

        515                 520                 525             





Ala Val Glu Arg Pro Ser Thr Glu Leu 

    530                 535         





<210>  117

<211>  490

<212>  PRT

<213>  Homo sapiens



<400>  117



Met Leu Met Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser 

1               5                   10                  15      





Pro Pro Thr Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe 

            20                  25                  30          





Ser Asn Val Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp 

        35                  40                  45              





Cys Pro Thr Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala 

    50                  55                  60                  





Gln Leu Leu Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp 

65                  70                  75                  80  





Pro Gln Gly Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr 

                85                  90                  95      





His Gln Phe Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys 

            100                 105                 110         





Ala Leu Gly His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu 

        115                 120                 125             





Glu Arg Gln Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr 

    130                 135                 140                 





Gln Val Leu Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro 

145                 150                 155                 160 





Val Leu Met His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala 

                165                 170                 175     





Val Gly Gln Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala 

            180                 185                 190         





Thr Leu Trp Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala 

        195                 200                 205             





Glu His Pro Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu 

    210                 215                 220                 





Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln 

225                 230                 235                 240 





Gln Leu Ser Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu 

                245                 250                 255     





Phe Gly Val Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn 

            260                 265                 270         





His Leu Tyr His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly 

        275                 280                 285             





Ser Gln Glu Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu 

    290                 295                 300                 





Val Asp Tyr Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile 

305                 310                 315                 320 





Ala Gly Arg Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His 

                325                 330                 335     





Val Ala Val Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro 

            340                 345                 350         





Phe Asn Glu Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe 

        355                 360                 365             





Gln Glu Leu Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu 

    370                 375                 380                 





Tyr Gly Asp Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu 

385                 390                 395                 400 





Lys Cys His Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly 

                405                 410                 415     





Ala Pro Phe Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro 

            420                 425                 430         





Glu Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile 

        435                 440                 445             





Val Lys Thr Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr 

    450                 455                 460                 





Cys Pro Tyr Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly 

465                 470                 475                 480 





Pro Ala Val Glu Arg Pro Ser Thr Glu Leu 

                485                 490 





<210>  118

<211>  630

<212>  PRT

<213>  Homo sapiens



<400>  118



Met Ser Arg Glu Cys Asp Pro Gly Ala Arg Trp Gly Ile Phe Leu Ala 

1               5                   10                  15      





Ser Gly Gly Ala Leu Asn Ala Arg Leu Ser Pro Ser Ser Leu Ser Ser 

            20                  25                  30          





Ala Gly Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu Pro 

        35                  40                  45              





Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val Asn 

    50                  55                  60                  





Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg Phe 

65                  70                  75                  80  





Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser Gly 

                85                  90                  95      





Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser Leu 

            100                 105                 110         





Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg Trp 

        115                 120                 125             





Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met Arg 

    130                 135                 140                 





Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr Tyr 

145                 150                 155                 160 





Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val Ser 

                165                 170                 175     





Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr Pro 

            180                 185                 190         





Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu Ala 

        195                 200                 205             





Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly Thr 

    210                 215                 220                 





Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe Phe 

225                 230                 235                 240 





Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly His 

                245                 250                 255     





Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln Tyr 

            260                 265                 270         





Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu Asp 

        275                 280                 285             





Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met His 

    290                 295                 300                 





Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln Glu 

305                 310                 315                 320 





Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp Leu 

                325                 330                 335     





Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro Thr 

            340                 345                 350         





Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile Gly 

        355                 360                 365             





Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser Gly 

    370                 375                 380                 





Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val Gln 

385                 390                 395                 400 





Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr His 

                405                 410                 415     





Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu Tyr 

            420                 425                 430         





Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr Gly 

        435                 440                 445             





Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg Ile 

    450                 455                 460                 





Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val Asp 

465                 470                 475                 480 





Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu Tyr 

                485                 490                 495     





Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu Val 

            500                 505                 510         





Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp Ile 

        515                 520                 525             





Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His Pro 

    530                 535                 540                 





Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe Ser 

545                 550                 555                 560 





Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp Lys 

                565                 570                 575     





Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr Ala 

            580                 585                 590         





Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr Val 

        595                 600                 605             





Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val Glu 

    610                 615                 620                 





Arg Pro Ser Thr Glu Leu 

625                 630 





<210>  119

<211>  630

<212>  PRT

<213>  Homo sapiens



<400>  119



Met Ser Arg Glu Cys Asp Pro Gly Ala Arg Trp Gly Ile Phe Leu Ala 

1               5                   10                  15      





Ser Trp Trp Ser Leu Glu Cys Gln Leu Ser Pro Ser Ser Leu Ser Ser 

            20                  25                  30          





Ala Gly Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu Pro 

        35                  40                  45              





Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val Asn 

    50                  55                  60                  





Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg Phe 

65                  70                  75                  80  





Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser Gly 

                85                  90                  95      





Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser Leu 

            100                 105                 110         





Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg Trp 

        115                 120                 125             





Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met Arg 

    130                 135                 140                 





Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr Tyr 

145                 150                 155                 160 





Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val Ser 

                165                 170                 175     





Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr Pro 

            180                 185                 190         





Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu Ala 

        195                 200                 205             





Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly Thr 

    210                 215                 220                 





Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe Phe 

225                 230                 235                 240 





Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly His 

                245                 250                 255     





Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln Tyr 

            260                 265                 270         





Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu Asp 

        275                 280                 285             





Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met His 

    290                 295                 300                 





Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln Glu 

305                 310                 315                 320 





Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp Leu 

                325                 330                 335     





Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro Thr 

            340                 345                 350         





Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile Gly 

        355                 360                 365             





Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser Gly 

    370                 375                 380                 





Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val Gln 

385                 390                 395                 400 





Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr His 

                405                 410                 415     





Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu Tyr 

            420                 425                 430         





Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr Gly 

        435                 440                 445             





Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg Ile 

    450                 455                 460                 





Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val Asp 

465                 470                 475                 480 





Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu Tyr 

                485                 490                 495     





Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu Val 

            500                 505                 510         





Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp Ile 

        515                 520                 525             





Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His Pro 

    530                 535                 540                 





Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe Ser 

545                 550                 555                 560 





Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp Lys 

                565                 570                 575     





Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr Ala 

            580                 585                 590         





Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr Val 

        595                 600                 605             





Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val Glu 

    610                 615                 620                 





Arg Pro Ser Thr Glu Leu 

625                 630 





<210>  120

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  120



Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 

1               5                   10                  15      





Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 

            20                  25                  30          





Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 

        35                  40                  45              





Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 

    50                  55                  60                  





Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 

65                  70                  75                  80  





Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 

                85                  90                  95      





Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 

            100                 105                 110         





Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 

        115                 120                 125             





Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 

    130                 135                 140                 





Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 

145                 150                 155                 160 





Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 

                165                 170                 175     





Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 

            180                 185                 190         





Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 

        195                 200                 205             





Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 

    210                 215                 220                 





Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 

225                 230                 235                 240 





Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 

                245                 250                 255     





<210>  121

<211>  157

<212>  PRT

<213>  Homo sapiens



<400>  121



Met Ser Ser Glu Glu Gly Lys Leu Phe Val Gly Gly Leu Asn Phe Asn 

1               5                   10                  15      





Thr Asp Glu Gln Ala Leu Glu Asp His Phe Ser Ser Phe Gly Pro Ile 

            20                  25                  30          





Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 

        35                  40                  45              





Phe Gly Phe Ile Thr Phe Thr Asn Pro Glu His Ala Ser Val Ala Met 

    50                  55                  60                  





Arg Ala Met Asn Gly Glu Ser Leu Asp Gly Arg Gln Ile Arg Val Asp 

65                  70                  75                  80  





His Ala Gly Lys Ser Ala Arg Gly Thr Arg Gly Gly Gly Phe Gly Ala 

                85                  90                  95      





His Gly Arg Gly Arg Ser Tyr Ser Arg Gly Gly Gly Asp Gln Gly Tyr 

            100                 105                 110         





Gly Ser Gly Arg Tyr Tyr Asp Ser Arg Pro Gly Gly Tyr Gly Tyr Gly 

        115                 120                 125             





Tyr Gly Arg Ser Arg Asp Tyr Asn Gly Arg Asn Gln Gly Gly Tyr Asp 

    130                 135                 140                 





Arg Tyr Ser Gly Gly Asn Tyr Arg Asp Asn Tyr Asp Asn 

145                 150                 155         





<210>  122

<211>  223

<212>  PRT

<213>  Homo sapiens



<400>  122



Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu 

1               5                   10                  15      





Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg 

            20                  25                  30          





Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro 

        35                  40                  45              





Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg 

    50                  55                  60                  





Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu 

65                  70                  75                  80  





Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 

                85                  90                  95      





His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 

            100                 105                 110         





Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 

        115                 120                 125             





Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 

    130                 135                 140                 





Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly 

145                 150                 155                 160 





Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu 

                165                 170                 175     





Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr 

            180                 185                 190         





Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn 

        195                 200                 205             





Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val 

    210                 215                 220             





<210>  123

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  123



Met Ala Glu Ile His Thr Pro Tyr Ser Ser Leu Lys Lys Leu Leu Ser 

1               5                   10                  15      





Leu Leu Asn Gly Phe Val Ala Val Ser Gly Ile Ile Leu Val Gly Leu 

            20                  25                  30          





Gly Ile Gly Gly Lys Cys Gly Gly Ala Ser Leu Thr Asn Val Leu Gly 

        35                  40                  45              





Leu Ser Ser Ala Tyr Leu Leu His Val Gly Asn Leu Cys Leu Val Met 

    50                  55                  60                  





Gly Cys Ile Thr Val Leu Leu Gly Cys Ala Gly Trp Tyr Gly Ala Thr 

65                  70                  75                  80  





Lys Glu Ser Arg Gly Thr Leu Leu Phe Cys Ile Leu Ser Met Val Ile 

                85                  90                  95      





Val Leu Ile Met Glu Val Thr Ala Ala Thr Val Val Leu Leu Phe Phe 

            100                 105                 110         





Pro Ile Val Gly Asp Val Ala Leu Glu His Thr Phe Val Thr Leu Arg 

        115                 120                 125             





Lys Asn Tyr Arg Gly Tyr Asn Glu Pro Asp Asp Tyr Ser Thr Gln Trp 

    130                 135                 140                 





Asn Leu Val Met Glu Lys Leu Lys Cys Cys Gly Val Asn Asn Tyr Thr 

145                 150                 155                 160 





Asp Phe Ser Gly Ser Ser Phe Glu Met Thr Thr Gly His Thr Tyr Pro 

                165                 170                 175     





Arg Ser Cys Cys Lys Ser Ile Gly Ser Val Ser Cys Asp Gly Arg Asp 

            180                 185                 190         





Val Ser Pro Asn Val Ile His Gln Lys Gly Cys Phe His Lys Leu Leu 

        195                 200                 205             





Lys Ile Thr Lys Thr Gln Ser Phe Thr Leu Ser Gly Ser Ser Leu Gly 

    210                 215                 220                 





Ala Ala Val Ile Gln Arg Trp Gly Ser Arg Tyr Val Ala Gln Ala Gly 

225                 230                 235                 240 





Leu Glu Leu Leu Ala 

                245 





<210>  124

<211>  244

<212>  PRT

<213>  Homo sapiens



<400>  124



Met Ala Glu Ile His Thr Pro Tyr Ser Ser Leu Lys Lys Leu Leu Ser 

1               5                   10                  15      





Leu Leu Asn Gly Phe Val Ala Val Ser Gly Ile Ile Leu Val Gly Leu 

            20                  25                  30          





Gly Ile Gly Gly Lys Cys Gly Gly Ala Ser Leu Thr Asn Val Leu Gly 

        35                  40                  45              





Leu Ser Ser Ala Tyr Leu Leu His Val Gly Asn Leu Cys Leu Val Met 

    50                  55                  60                  





Gly Cys Ile Thr Val Leu Leu Gly Cys Ala Gly Trp Tyr Gly Ala Thr 

65                  70                  75                  80  





Lys Glu Ser Arg Gly Thr Leu Leu Phe Cys Ile Leu Ser Met Val Ile 

                85                  90                  95      





Val Leu Ile Met Glu Val Thr Ala Ala Thr Val Val Leu Leu Phe Phe 

            100                 105                 110         





Pro Ile Val Gly Asp Val Ala Leu Glu His Thr Phe Val Thr Leu Arg 

        115                 120                 125             





Lys Asn Tyr Arg Gly Tyr Asn Glu Pro Asp Asp Tyr Ser Thr Gln Trp 

    130                 135                 140                 





Asn Leu Val Met Glu Lys Leu Lys Cys Cys Gly Val Asn Asn Tyr Thr 

145                 150                 155                 160 





Asp Phe Ser Gly Ser Ser Phe Glu Met Thr Thr Gly His Thr Tyr Pro 

                165                 170                 175     





Arg Ser Cys Cys Lys Ser Ile Gly Ser Val Ser Cys Asp Gly Arg Asp 

            180                 185                 190         





Val Ser Pro Asn Val Ile His Gln Lys Gly Cys Phe His Lys Leu Leu 

        195                 200                 205             





Lys Ile Thr Lys Thr Gln Ser Phe Thr Leu Ser Gly Ser Ser Leu Gly 

    210                 215                 220                 





Ala Ala Val Ile Gln Leu Pro Gly Ile Leu Ala Thr Leu Leu Leu Phe 

225                 230                 235                 240 





Ile Lys Leu Gly 

                





<210>  125

<211>  219

<212>  PRT

<213>  Homo sapiens



<400>  125



Met Ala Glu Ile His Thr Pro Tyr Ser Ser Leu Lys Lys Leu Leu Ser 

1               5                   10                  15      





Leu Leu Asn Gly Phe Val Ala Val Ser Gly Ile Ile Leu Val Gly Leu 

            20                  25                  30          





Gly Ile Gly Gly Lys Cys Gly Gly Ala Ser Leu Thr Asn Val Leu Gly 

        35                  40                  45              





Leu Ser Ser Ala Tyr Leu Leu His Val Gly Asn Leu Cys Leu Val Met 

    50                  55                  60                  





Gly Cys Ile Thr Val Leu Leu Gly Cys Ala Gly Trp Tyr Gly Ala Thr 

65                  70                  75                  80  





Lys Glu Ser Arg Gly Thr Leu Leu Phe Val Gly Asp Val Ala Leu Glu 

                85                  90                  95      





His Thr Phe Val Thr Leu Arg Lys Asn Tyr Arg Gly Tyr Asn Glu Pro 

            100                 105                 110         





Asp Asp Tyr Ser Thr Gln Trp Asn Leu Val Met Glu Lys Leu Lys Cys 

        115                 120                 125             





Cys Gly Val Asn Asn Tyr Thr Asp Phe Ser Gly Ser Ser Phe Glu Met 

    130                 135                 140                 





Thr Thr Gly His Thr Tyr Pro Arg Ser Cys Cys Lys Ser Ile Gly Ser 

145                 150                 155                 160 





Val Ser Cys Asp Gly Arg Asp Val Ser Pro Asn Val Ile His Gln Lys 

                165                 170                 175     





Gly Cys Phe His Lys Leu Leu Lys Ile Thr Lys Thr Gln Ser Phe Thr 

            180                 185                 190         





Leu Ser Gly Ser Ser Leu Gly Ala Ala Val Ile Gln Leu Pro Gly Ile 

        195                 200                 205             





Leu Ala Thr Leu Leu Leu Phe Ile Lys Leu Gly 

    210                 215                 





<210>  126

<211>  160

<212>  PRT

<213>  Homo sapiens



<400>  126



Met Ala Glu Ile His Thr Pro Tyr Ser Ser Leu Lys Lys Leu Leu Ser 

1               5                   10                  15      





Leu Leu Asn Gly Phe Val Ala Val Ser Gly Ile Ile Leu Val Gly Leu 

            20                  25                  30          





Gly Ile Gly Gly Lys Cys Gly Gly Ala Ser Leu Thr Asn Val Leu Gly 

        35                  40                  45              





Leu Ser Ser Ala Tyr Leu Leu His Val Gly Asn Leu Cys Leu Val Met 

    50                  55                  60                  





Gly Cys Ile Thr Val Leu Leu Gly Cys Ala Gly Trp Tyr Gly Ala Thr 

65                  70                  75                  80  





Lys Glu Ser Arg Gly Thr Leu Leu Phe Cys Ile Leu Ser Met Val Ile 

                85                  90                  95      





Val Leu Ile Met Glu Val Thr Ala Ala Thr Val Val Leu Leu Phe Phe 

            100                 105                 110         





Pro Ile Val Gly Asp Val Ala Leu Glu His Thr Phe Val Thr Leu Arg 

        115                 120                 125             





Lys Asn Tyr Arg Gly Tyr Asn Glu Pro Asp Asp Tyr Ser Thr Gln Trp 

    130                 135                 140                 





Asn Leu Val Met Glu Lys Gly Leu Ser Lys Tyr Phe Phe Ser Ser Leu 

145                 150                 155                 160 





<210>  127

<211>  431

<212>  PRT

<213>  Homo sapiens



<400>  127



Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 

1               5                   10                  15      





Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 

            20                  25                  30          





Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 

        35                  40                  45              





His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 

    50                  55                  60                  





Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 

65                  70                  75                  80  





Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 

                85                  90                  95      





Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 

            100                 105                 110         





Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 

        115                 120                 125             





Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 

    130                 135                 140                 





Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 

145                 150                 155                 160 





Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 

                165                 170                 175     





Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 

            180                 185                 190         





Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 

        195                 200                 205             





Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 

    210                 215                 220                 





Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 

225                 230                 235                 240 





Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 

                245                 250                 255     





Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 

            260                 265                 270         





His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 

        275                 280                 285             





Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 

    290                 295                 300                 





Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 

305                 310                 315                 320 





Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 

                325                 330                 335     





Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 

            340                 345                 350         





Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 

        355                 360                 365             





Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 

    370                 375                 380                 





Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 

385                 390                 395                 400 





Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 

                405                 410                 415     





Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 

            420                 425                 430     





<210>  128

<211>  414

<212>  PRT

<213>  Homo sapiens



<400>  128



Met Val Phe His Leu Arg Thr Arg Tyr Glu Gln Ala Asn Cys Asp Cys 

1               5                   10                  15      





Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile His 

            20                  25                  30          





Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile Asp 

        35                  40                  45              





Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly Lys 

    50                  55                  60                  





Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser Ala 

65                  70                  75                  80  





Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu Gln 

                85                  90                  95      





Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg Arg 

            100                 105                 110         





Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln Glu 

        115                 120                 125             





Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro Pro 

    130                 135                 140                 





Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Phe 

145                 150                 155                 160 





Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe 

                165                 170                 175     





Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys 

            180                 185                 190         





Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys 

        195                 200                 205             





Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg 

    210                 215                 220                 





Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu 

225                 230                 235                 240 





Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His 

                245                 250                 255     





Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala 

            260                 265                 270         





Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn 

        275                 280                 285             





Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu 

    290                 295                 300                 





Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val 

305                 310                 315                 320 





Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser 

                325                 330                 335     





Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr 

            340                 345                 350         





Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln 

        355                 360                 365             





Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala 

    370                 375                 380                 





Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro 

385                 390                 395                 400 





Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 

                405                 410                 





<210>  129

<211>  591

<212>  PRT

<213>  Homo sapiens



<400>  129



Met Lys Tyr Ile Leu Val Thr Gly Gly Val Ile Ser Gly Ile Gly Lys 

1               5                   10                  15      





Gly Ile Ile Ala Ser Ser Val Gly Thr Ile Leu Lys Ser Cys Gly Leu 

            20                  25                  30          





His Val Thr Ser Ile Lys Ile Asp Pro Tyr Ile Asn Ile Asp Ala Gly 

        35                  40                  45              





Thr Phe Ser Pro Tyr Glu His Gly Glu Val Phe Val Leu Asp Asp Gly 

    50                  55                  60                  





Gly Glu Val Asp Leu Asp Leu Gly Asn Tyr Glu Arg Phe Leu Asp Ile 

65                  70                  75                  80  





Arg Leu Thr Lys Asp Asn Asn Leu Thr Thr Gly Lys Ile Tyr Gln Tyr 

                85                  90                  95      





Val Ile Asn Lys Glu Arg Lys Gly Asp Tyr Leu Gly Lys Thr Val Gln 

            100                 105                 110         





Val Val Pro His Ile Thr Asp Ala Ile Gln Glu Trp Val Met Arg Gln 

        115                 120                 125             





Ala Leu Ile Pro Val Asp Glu Asp Gly Leu Glu Pro Gln Val Cys Val 

    130                 135                 140                 





Ile Glu Leu Gly Gly Thr Val Gly Asp Ile Glu Ser Met Pro Phe Ile 

145                 150                 155                 160 





Glu Ala Phe Arg Gln Phe Gln Phe Lys Val Lys Arg Glu Asn Phe Cys 

                165                 170                 175     





Asn Ile His Val Ser Leu Val Pro Gln Pro Ser Ser Thr Gly Glu Gln 

            180                 185                 190         





Lys Thr Lys Pro Thr Gln Asn Ser Val Arg Glu Leu Arg Gly Leu Gly 

        195                 200                 205             





Leu Ser Pro Asp Leu Val Val Cys Arg Cys Ser Asn Pro Leu Asp Thr 

    210                 215                 220                 





Ser Val Lys Glu Lys Ile Ser Met Phe Cys His Val Glu Pro Glu Gln 

225                 230                 235                 240 





Val Ile Cys Val His Asp Val Ser Ser Ile Tyr Arg Val Pro Leu Leu 

                245                 250                 255     





Leu Glu Glu Gln Gly Val Val Asp Tyr Phe Leu Arg Arg Leu Asp Leu 

            260                 265                 270         





Pro Ile Glu Arg Gln Pro Arg Lys Met Leu Met Lys Trp Lys Glu Met 

        275                 280                 285             





Ala Asp Arg Tyr Asp Arg Leu Leu Glu Thr Cys Ser Ile Ala Leu Val 

    290                 295                 300                 





Gly Lys Tyr Thr Lys Phe Ser Asp Ser Tyr Ala Ser Val Ile Lys Ala 

305                 310                 315                 320 





Leu Glu His Ser Ala Leu Ala Ile Asn His Lys Leu Glu Ile Lys Tyr 

                325                 330                 335     





Ile Asp Ser Ala Asp Leu Glu Pro Ile Thr Ser Gln Glu Glu Pro Val 

            340                 345                 350         





Arg Tyr His Glu Ala Trp Gln Lys Leu Cys Ser Ala His Gly Val Leu 

        355                 360                 365             





Val Pro Gly Gly Phe Gly Val Arg Gly Thr Glu Gly Lys Ile Gln Ala 

    370                 375                 380                 





Ile Ala Trp Ala Arg Asn Gln Lys Lys Pro Phe Leu Gly Val Cys Leu 

385                 390                 395                 400 





Gly Met Gln Leu Ala Val Val Glu Phe Ser Arg Asn Val Leu Gly Trp 

                405                 410                 415     





Gln Asp Ala Asn Ser Thr Glu Phe Asp Pro Thr Thr Ser His Pro Val 

            420                 425                 430         





Val Val Asp Met Pro Glu His Asn Pro Gly Gln Met Gly Gly Thr Met 

        435                 440                 445             





Arg Leu Gly Lys Arg Arg Thr Leu Phe Gln Thr Lys Asn Ser Val Met 

    450                 455                 460                 





Arg Lys Leu Tyr Gly Asp Ala Asp Tyr Leu Glu Glu Arg His Arg His 

465                 470                 475                 480 





Arg Phe Glu Val Asn Pro Val Trp Lys Lys Cys Leu Glu Glu Gln Gly 

                485                 490                 495     





Leu Lys Phe Val Gly Gln Asp Val Glu Gly Glu Arg Met Glu Ile Val 

            500                 505                 510         





Glu Leu Glu Asp His Pro Phe Phe Val Gly Val Gln Tyr His Pro Glu 

        515                 520                 525             





Phe Leu Ser Arg Pro Ile Lys Pro Ser Pro Pro Tyr Phe Gly Leu Leu 

    530                 535                 540                 





Leu Ala Ser Val Gly Arg Leu Ser His Tyr Leu Gln Lys Gly Cys Arg 

545                 550                 555                 560 





Leu Ser Pro Arg Asp Thr Tyr Ser Asp Arg Ser Gly Ser Ser Ser Pro 

                565                 570                 575     





Asp Ser Glu Ile Thr Glu Leu Lys Phe Pro Ser Ile Asn His Asp 

            580                 585                 590     





<210>  130

<211>  360

<212>  PRT

<213>  Homo sapiens



<400>  130



Met Phe Cys His Val Glu Pro Glu Gln Val Ile Cys Val His Asp Val 

1               5                   10                  15      





Ser Ser Ile Tyr Arg Val Pro Leu Leu Leu Glu Glu Gln Gly Val Val 

            20                  25                  30          





Asp Tyr Phe Leu Arg Arg Leu Asp Leu Pro Ile Glu Arg Gln Pro Arg 

        35                  40                  45              





Lys Met Leu Met Lys Trp Lys Glu Met Ala Asp Arg Tyr Asp Arg Leu 

    50                  55                  60                  





Leu Glu Thr Cys Ser Ile Ala Leu Val Gly Lys Tyr Thr Lys Phe Ser 

65                  70                  75                  80  





Asp Ser Tyr Ala Ser Val Ile Lys Ala Leu Glu His Ser Ala Leu Ala 

                85                  90                  95      





Ile Asn His Lys Leu Glu Ile Lys Tyr Ile Asp Ser Ala Asp Leu Glu 

            100                 105                 110         





Pro Ile Thr Ser Gln Glu Glu Pro Val Arg Tyr His Glu Ala Trp Gln 

        115                 120                 125             





Lys Leu Cys Ser Ala His Gly Val Leu Val Pro Gly Gly Phe Gly Val 

    130                 135                 140                 





Arg Gly Thr Glu Gly Lys Ile Gln Ala Ile Ala Trp Ala Arg Asn Gln 

145                 150                 155                 160 





Lys Lys Pro Phe Leu Gly Val Cys Leu Gly Met Gln Leu Ala Val Val 

                165                 170                 175     





Glu Phe Ser Arg Asn Val Leu Gly Trp Gln Asp Ala Asn Ser Thr Glu 

            180                 185                 190         





Phe Asp Pro Thr Thr Ser His Pro Val Val Val Asp Met Pro Glu His 

        195                 200                 205             





Asn Pro Gly Gln Met Gly Gly Thr Met Arg Leu Gly Lys Arg Arg Thr 

    210                 215                 220                 





Leu Phe Gln Thr Lys Asn Ser Val Met Arg Lys Leu Tyr Gly Asp Ala 

225                 230                 235                 240 





Asp Tyr Leu Glu Glu Arg His Arg His Arg Phe Glu Val Asn Pro Val 

                245                 250                 255     





Trp Lys Lys Cys Leu Glu Glu Gln Gly Leu Lys Phe Val Gly Gln Asp 

            260                 265                 270         





Val Glu Gly Glu Arg Met Glu Ile Val Glu Leu Glu Asp His Pro Phe 

        275                 280                 285             





Phe Val Gly Val Gln Tyr His Pro Glu Phe Leu Ser Arg Pro Ile Lys 

    290                 295                 300                 





Pro Ser Pro Pro Tyr Phe Gly Leu Leu Leu Ala Ser Val Gly Arg Leu 

305                 310                 315                 320 





Ser His Tyr Leu Gln Lys Gly Cys Arg Leu Ser Pro Arg Asp Thr Tyr 

                325                 330                 335     





Ser Asp Arg Ser Gly Ser Ser Ser Pro Asp Ser Glu Ile Thr Glu Leu 

            340                 345                 350         





Lys Phe Pro Ser Ile Asn His Asp 

        355                 360 





<210>  131

<211>  209

<212>  PRT

<213>  Homo sapiens



<400>  131



Met Glu Leu Asn Ser Leu Leu Ile Leu Leu Glu Ala Ala Glu Tyr Leu 

1               5                   10                  15      





Glu Arg Arg Asp Arg Glu Ala Glu His Gly Tyr Ala Ser Val Leu Pro 

            20                  25                  30          





Phe Asp Gly Asp Phe Ala Arg Glu Lys Thr Lys Ala Ala Gly Leu Val 

        35                  40                  45              





Arg Lys Ala Pro Asn Asn Arg Ser Ser His Asn Glu Leu Glu Lys His 

    50                  55                  60                  





Arg Arg Ala Lys Leu Arg Leu Tyr Leu Glu Gln Leu Lys Gln Leu Val 

65                  70                  75                  80  





Pro Leu Gly Pro Asp Ser Thr Arg His Thr Thr Leu Ser Leu Leu Lys 

                85                  90                  95      





Arg Ala Lys Val His Ile Lys Lys Leu Glu Glu Gln Asp Arg Arg Ala 

            100                 105                 110         





Leu Ser Ile Lys Glu Gln Leu Gln Gln Glu His Arg Phe Leu Lys Arg 

        115                 120                 125             





Arg Leu Glu Gln Leu Ser Val Gln Ser Val Glu Arg Val Arg Thr Asp 

    130                 135                 140                 





Ser Thr Gly Ser Ala Val Ser Thr Asp Asp Ser Glu Gln Glu Val Asp 

145                 150                 155                 160 





Ile Glu Gly Met Glu Phe Gly Pro Gly Glu Leu Asp Ser Val Gly Ser 

                165                 170                 175     





Ser Ser Asp Ala Asp Asp His Tyr Ser Leu Gln Ser Gly Thr Gly Gly 

            180                 185                 190         





Asp Ser Gly Phe Gly Pro His Cys Arg Arg Leu Gly Arg Pro Ala Leu 

        195                 200                 205             





Ser 

    





<210>  132

<211>  222

<212>  PRT

<213>  Homo sapiens



<400>  132



Met Cys Leu Arg Leu Gly Gly Leu Ser Val Gly Asp Phe Arg Lys Val 

1               5                   10                  15      





Leu Met Lys Thr Gly Leu Val Leu Val Val Leu Gly His Val Ser Phe 

            20                  25                  30          





Ile Thr Ala Ala Leu Phe His Gly Thr Val Leu Arg Tyr Val Gly Thr 

        35                  40                  45              





Pro Gln Asp Ala Val Ala Leu Gln Tyr Cys Val Val Asn Ile Leu Ser 

    50                  55                  60                  





Val Thr Ser Ala Ile Val Val Ile Thr Ser Gly Ile Ala Ala Ile Val 

65                  70                  75                  80  





Leu Ser Arg Tyr Leu Pro Ser Thr Pro Leu Arg Trp Thr Val Phe Ser 

                85                  90                  95      





Ser Ser Val Ala Cys Ala Leu Leu Ser Leu Thr Cys Ala Leu Gly Leu 

            100                 105                 110         





Leu Ala Ser Ile Ala Met Thr Phe Ala Thr Gln Gly Lys Ala Leu Leu 

        115                 120                 125             





Ala Ala Cys Thr Phe Gly Ser Ser Glu Leu Leu Ala Leu Ala Pro Asp 

    130                 135                 140                 





Cys Pro Phe Asp Pro Thr Arg Ile Tyr Ser Ser Ser Leu Cys Leu Trp 

145                 150                 155                 160 





Gly Ile Ala Leu Val Leu Cys Val Ala Glu Asn Val Phe Ala Val Arg 

                165                 170                 175     





Cys Ala Gln Leu Thr His Gln Leu Leu Glu Leu Arg Pro Trp Trp Gly 

            180                 185                 190         





Lys Ser Ser His His Met Met Arg Glu Asn Pro Glu Leu Val Glu Gly 

        195                 200                 205             





Arg Asp Leu Leu Ser Cys Thr Ser Ser Glu Pro Leu Thr Leu 

    210                 215                 220         





<210>  133

<211>  202

<212>  PRT

<213>  Homo sapiens



<400>  133



Met Cys Leu Arg Leu Gly Gly Leu Ser Val Gly Asp Phe Arg Lys Val 

1               5                   10                  15      





Leu Met Lys Thr Gly Leu Val Leu Val Val Leu Gly His Val Ser Phe 

            20                  25                  30          





Ile Thr Ala Ala Leu Phe His Gly Thr Val Leu Arg Tyr Val Gly Thr 

        35                  40                  45              





Pro Gln Asp Ala Val Ala Leu Gln Tyr Cys Val Val Asn Ile Leu Ser 

    50                  55                  60                  





Val Thr Ser Ala Ile Val Arg Trp Thr Val Phe Ser Ser Ser Val Ala 

65                  70                  75                  80  





Cys Ala Leu Leu Ser Leu Thr Cys Ala Leu Gly Leu Leu Ala Ser Ile 

                85                  90                  95      





Ala Met Thr Phe Ala Thr Gln Gly Lys Ala Leu Leu Ala Ala Cys Thr 

            100                 105                 110         





Phe Gly Ser Ser Glu Leu Leu Ala Leu Ala Pro Asp Cys Pro Phe Asp 

        115                 120                 125             





Pro Thr Arg Ile Tyr Ser Ser Ser Leu Cys Leu Trp Gly Ile Ala Leu 

    130                 135                 140                 





Val Leu Cys Val Ala Glu Asn Val Phe Ala Val Arg Cys Ala Gln Leu 

145                 150                 155                 160 





Thr His Gln Leu Leu Glu Leu Arg Pro Trp Trp Gly Lys Ser Ser His 

                165                 170                 175     





His Met Met Arg Glu Asn Pro Glu Leu Val Glu Gly Arg Asp Leu Leu 

            180                 185                 190         





Ser Cys Thr Ser Ser Glu Pro Leu Thr Leu 

        195                 200         





<210>  134

<211>  169

<212>  PRT

<213>  Homo sapiens



<400>  134



Met Cys Leu Arg Leu Gly Gly Leu Ser Val Gly Asp Phe Arg Lys Val 

1               5                   10                  15      





Leu Met Lys Thr Gly Leu Val Leu Val Val Leu Gly His Val Ser Phe 

            20                  25                  30          





Ile Thr Ala Ala Leu Phe His Gly Thr Val Leu Arg Tyr Val Gly Thr 

        35                  40                  45              





Pro Gln Asp Ala Val Ala Leu Gln Tyr Cys Val Val Asn Ile Leu Ser 

    50                  55                  60                  





Val Thr Ser Ala Ile Val Gly Lys Ala Leu Leu Ala Ala Cys Thr Phe 

65                  70                  75                  80  





Gly Ser Ser Glu Leu Leu Ala Leu Ala Pro Asp Cys Pro Phe Asp Pro 

                85                  90                  95      





Thr Arg Ile Tyr Ser Ser Ser Leu Cys Leu Trp Gly Ile Ala Leu Val 

            100                 105                 110         





Leu Cys Val Ala Glu Asn Val Phe Ala Val Arg Cys Ala Gln Leu Thr 

        115                 120                 125             





His Gln Leu Leu Glu Leu Arg Pro Trp Trp Gly Lys Ser Ser His His 

    130                 135                 140                 





Met Met Arg Glu Asn Pro Glu Leu Val Glu Gly Arg Asp Leu Leu Ser 

145                 150                 155                 160 





Cys Thr Ser Ser Glu Pro Leu Thr Leu 

                165                 





<210>  135

<211>  375

<212>  PRT

<213>  Homo sapiens



<400>  135



Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 

1               5                   10                  15      





Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 

            20                  25                  30          





Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 

        35                  40                  45              





Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 

    50                  55                  60                  





Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 

65                  70                  75                  80  





Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 

                85                  90                  95      





Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 

            100                 105                 110         





Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 

        115                 120                 125             





Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 

    130                 135                 140                 





Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 

145                 150                 155                 160 





His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 

                165                 170                 175     





Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 

            180                 185                 190         





Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 

        195                 200                 205             





Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 

    210                 215                 220                 





Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 

225                 230                 235                 240 





Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 

                245                 250                 255     





Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 

            260                 265                 270         





Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 

        275                 280                 285             





Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 

    290                 295                 300                 





Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 

305                 310                 315                 320 





Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 

                325                 330                 335     





Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 

            340                 345                 350         





Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 

        355                 360                 365             





Ile Val His Arg Lys Cys Phe 

    370                 375 





<210>  136

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  136



Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 

1               5                   10                  15      





Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 

            20                  25                  30          





Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 

        35                  40                  45              





Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 

    50                  55                  60                  





Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 

65                  70                  75                  80  





Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 

                85                  90                  95      





Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 

            100                 105                 110         





Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 

        115                 120                 125             





Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 

    130                 135                 140                 





Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 

145                 150                 155                 160 





Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 

                165                 170                 175     





Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 

            180                 185                 190         





Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 

        195                 200                 205             





Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 

    210                 215                 220                 





Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 

225                 230                 235                 240 





Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 

                245                 250                 255     





His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 

            260                 265                 270         





Leu Tyr Phe Tyr His 

        275         





<210>  137

<211>  381

<212>  PRT

<213>  Homo sapiens



<400>  137



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 

                325                 330                 335     





Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 

            340                 345                 350         





Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 

        355                 360                 365             





Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 

    370                 375                 380     





<210>  138

<211>  440

<212>  PRT

<213>  Homo sapiens



<400>  138



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 

                325                 330                 335     





Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 

            340                 345                 350         





Ser Gly Thr Thr Arg Leu Leu Ser Gly Ser Arg Pro Val Thr Gln Ala 

        355                 360                 365             





Gly Met Arg Trp Cys Asp Arg Ser Ser Leu Gln Ser Arg Thr Pro Gly 

    370                 375                 380                 





Phe Lys Arg Ser Phe His Phe Ser Leu Pro Ser Ser Trp Tyr Tyr Arg 

385                 390                 395                 400 





Ala His Val Phe His Val Asp Arg Phe Ala Trp Asp Ala Ser Asn His 

                405                 410                 415     





Gly Leu Ala Asp Leu Ala Lys Glu Glu Leu Arg Arg Lys Tyr Thr Gln 

            420                 425                 430         





Val Tyr Arg Leu Phe Leu Val Ser 

        435                 440 





<210>  139

<211>  384

<212>  PRT

<213>  Homo sapiens



<400>  139



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 

                325                 330                 335     





Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 

            340                 345                 350         





Ser Gly Thr Thr Arg Leu Leu Ser Ala Leu Gln Val Arg Pro Phe Glu 

        355                 360                 365             





Val Ser Gly Ser Ser His Ile Ser Ser Lys Lys Met Met Cys Ile Leu 

    370                 375                 380                 





<210>  140

<211>  364

<212>  PRT

<213>  Homo sapiens



<400>  140



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 

                325                 330                 335     





Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 

            340                 345                 350         





Ser Gly Thr Thr Arg Leu Leu Ser Val Leu Phe Met 

        355                 360                 





<210>  141

<211>  439

<212>  PRT

<213>  Homo sapiens



<400>  141



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 

                325                 330                 335     





Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 

            340                 345                 350         





Ser Gly Thr Thr Arg Leu Leu Ser Glu Thr Val Phe His Arg Val Ile 

        355                 360                 365             





Gln Asp Gly Leu Asp Leu Leu Ala Ser Arg Ser Ala Cys Leu Gly Leu 

    370                 375                 380                 





Pro Lys Cys Trp Asp Tyr Arg Arg Glu Pro Pro His Leu Ala Arg Ala 

385                 390                 395                 400 





His Val Phe His Val Asp Arg Phe Ala Trp Asp Ala Ser Asn His Gly 

                405                 410                 415     





Leu Ala Asp Leu Ala Lys Glu Glu Leu Arg Arg Lys Tyr Thr Gln Val 

            420                 425                 430         





Tyr Arg Leu Phe Leu Val Ser 

        435                 





<210>  142

<211>  525

<212>  PRT

<213>  Homo sapiens



<400>  142



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Gly Thr Glu Thr Pro Ser Val Leu Gln Lys 

                325                 330                 335     





His Thr Thr Glu Asn Val Ser Ala Thr Arg Thr Pro Pro Thr Pro Gln 

            340                 345                 350         





Lys Pro Thr Thr Val Asn Val Pro Ala Thr Ile Val Thr Pro Thr Pro 

        355                 360                 365             





Gln Lys Pro Thr Thr Ile Asn Val Pro Ala Thr Gly Val Ser Ser Thr 

    370                 375                 380                 





Pro Gln Arg His Thr Ile Val Asn Val Ser Ala Thr Gly Thr Leu Pro 

385                 390                 395                 400 





Thr Leu Gln Lys Pro Thr Arg Ala Asn Asp Ser Ala Thr Lys Ser Pro 

                405                 410                 415     





Ala Ala Ala Gln Thr Ser Phe Ile Ser Lys Thr Leu Ser Thr Lys Thr 

            420                 425                 430         





Pro Ser Ala Ala Gln Asn Pro Met Met Thr Asn Ala Ser Ala Thr Gln 

        435                 440                 445             





Ala Thr Leu Thr Ala Gln Lys Phe Thr Thr Ala Lys Val Ala Phe Thr 

    450                 455                 460                 





Gln Ser Pro Ser Ala Ala Pro Thr Arg Ser Thr Pro Val Ser Arg Thr 

465                 470                 475                 480 





Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 

                485                 490                 495     





Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 

            500                 505                 510         





Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 

        515                 520                 525 





<210>  143

<211>  551

<212>  PRT

<213>  Homo sapiens



<400>  143



Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 

1               5                   10                  15      





Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 

            20                  25                  30          





Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 

        35                  40                  45              





Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 

    50                  55                  60                  





Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 

65                  70                  75                  80  





Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 

                85                  90                  95      





Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 

            100                 105                 110         





Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 

        115                 120                 125             





Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 

    130                 135                 140                 





Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 

145                 150                 155                 160 





Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 

                165                 170                 175     





Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 

            180                 185                 190         





Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 

        195                 200                 205             





Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 

    210                 215                 220                 





Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 

225                 230                 235                 240 





Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 

                245                 250                 255     





Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 

            260                 265                 270         





Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 

        275                 280                 285             





Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 

    290                 295                 300                 





Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 

305                 310                 315                 320 





Thr Thr Pro Asn Ala Gln Gly Thr Glu Thr Pro Ser Val Leu Gln Lys 

                325                 330                 335     





His Thr Thr Glu Asn Val Ser Ala Thr Arg Thr Pro Pro Thr Pro Gln 

            340                 345                 350         





Lys Pro Thr Thr Val Asn Val Pro Ala Thr Ile Val Thr Pro Thr Pro 

        355                 360                 365             





Gln Lys Pro Thr Thr Ile Asn Val Pro Ala Thr Gly Val Ser Ser Thr 

    370                 375                 380                 





Pro Gln Arg His Thr Ile Val Asn Val Ser Ala Thr Gly Thr Leu Pro 

385                 390                 395                 400 





Thr Leu Gln Lys Pro Thr Arg Ala Asn Asp Ser Ala Thr Lys Ser Pro 

                405                 410                 415     





Ala Ala Ala Gln Thr Ser Phe Ile Ser Lys Thr Leu Ser Thr Lys Thr 

            420                 425                 430         





Pro Ser Ala Ala Gln Asn Pro Met Met Thr Asn Ala Ser Ala Thr Gln 

        435                 440                 445             





Ala Thr Leu Thr Ala Gln Lys Phe Thr Thr Ala Lys Val Ala Phe Thr 

    450                 455                 460                 





Gln Ser Pro Ser Ala Ala Arg Lys Ser Thr Asn Val His Ser Pro Val 

465                 470                 475                 480 





Thr Asn Gly Leu Lys Ser Thr Gln Arg Phe Pro Ser Ala His Ile Thr 

                485                 490                 495     





Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu 

            500                 505                 510         





Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu 

        515                 520                 525             





Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu 

    530                 535                 540                 





Val Thr Met Gly Leu Leu Thr 

545                 550     





<210>  144

<211>  209

<212>  PRT

<213>  Homo sapiens



<400>  144



Met Gly Lys Gly Asp Pro Asn Lys Pro Arg Gly Lys Met Ser Ser Tyr 

1               5                   10                  15      





Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 

            20                  25                  30          





Asp Ser Ser Val Asn Phe Ala Glu Phe Ser Lys Lys Cys Ser Glu Arg 

        35                  40                  45              





Trp Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala 

    50                  55                  60                  





Lys Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro 

65                  70                  75                  80  





Pro Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys 

                85                  90                  95      





Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu His Arg Pro Lys 

            100                 105                 110         





Ile Lys Ser Glu His Pro Gly Leu Ser Ile Gly Asp Thr Ala Lys Lys 

        115                 120                 125             





Leu Gly Glu Met Trp Ser Glu Gln Ser Ala Lys Asp Lys Gln Pro Tyr 

    130                 135                 140                 





Glu Gln Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 

145                 150                 155                 160 





Ala Tyr Arg Ala Lys Gly Lys Ser Glu Ala Gly Lys Lys Gly Pro Gly 

                165                 170                 175     





Arg Pro Thr Gly Ser Lys Lys Lys Asn Glu Pro Glu Asp Glu Glu Glu 

            180                 185                 190         





Glu Glu Glu Glu Glu Asp Glu Asp Glu Glu Glu Glu Asp Glu Asp Glu 

        195                 200                 205             





Glu 

    





<210>  145

<211>  304

<212>  PRT

<213>  Homo sapiens



<400>  145



Met Phe Asn Ser Val Asn Leu Gly Asn Phe Cys Ser Pro Ser Arg Lys 

1               5                   10                  15      





Glu Arg Gly Ala Asp Phe Gly Glu Arg Gly Ser Cys Ala Ser Asn Leu 

            20                  25                  30          





Tyr Leu Pro Ser Cys Thr Tyr Tyr Met Pro Glu Phe Ser Thr Val Ser 

        35                  40                  45              





Ser Phe Leu Pro Gln Ala Pro Ser Arg Gln Ile Ser Tyr Pro Tyr Ser 

    50                  55                  60                  





Ala Gln Val Pro Pro Val Arg Glu Val Ser Tyr Gly Leu Glu Pro Ser 

65                  70                  75                  80  





Gly Lys Trp His His Arg Asn Ser Tyr Ser Ser Cys Tyr Ala Ala Ala 

                85                  90                  95      





Asp Glu Leu Met His Arg Glu Cys Leu Pro Pro Ser Thr Val Thr Glu 

            100                 105                 110         





Ile Leu Met Lys Asn Glu Gly Ser Tyr Gly Gly His His His Pro Ser 

        115                 120                 125             





Ala Pro His Ala Thr Pro Ala Gly Phe Tyr Ser Ser Val Asn Lys Asn 

    130                 135                 140                 





Ser Val Leu Pro Gln Ala Phe Asp Arg Phe Phe Asp Asn Ala Tyr Cys 

145                 150                 155                 160 





Gly Gly Gly Asp Pro Pro Ala Glu Pro Pro Cys Ser Gly Lys Gly Glu 

                165                 170                 175     





Ala Lys Gly Glu Pro Glu Ala Pro Pro Ala Ser Gly Leu Ala Ser Arg 

            180                 185                 190         





Ala Glu Ala Gly Ala Glu Ala Glu Ala Glu Glu Glu Asn Thr Asn Pro 

        195                 200                 205             





Ser Ser Ser Gly Ser Ala His Ser Val Ala Lys Glu Pro Ala Lys Gly 

    210                 215                 220                 





Ala Ala Pro Asn Ala Pro Arg Thr Arg Lys Lys Arg Cys Pro Tyr Ser 

225                 230                 235                 240 





Lys Phe Gln Ile Arg Glu Leu Glu Arg Glu Phe Phe Phe Asn Val Tyr 

                245                 250                 255     





Ile Asn Lys Glu Lys Arg Leu Gln Leu Ser Arg Met Leu Asn Leu Thr 

            260                 265                 270         





Asp Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Glu Lys 

        275                 280                 285             





Lys Leu Ser Arg Asp Arg Leu Gln Tyr Phe Ser Gly Asn Pro Leu Leu 

    290                 295                 300                 





<210>  146

<211>  532

<212>  PRT

<213>  Homo sapiens



<400>  146



Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 

1               5                   10                  15      





Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 

            20                  25                  30          





Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 

        35                  40                  45              





Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 

    50                  55                  60                  





Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 

65                  70                  75                  80  





Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 

                85                  90                  95      





Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 

            100                 105                 110         





Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 

        115                 120                 125             





Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 

    130                 135                 140                 





Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 

145                 150                 155                 160 





Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 

                165                 170                 175     





Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 

            180                 185                 190         





Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 

        195                 200                 205             





Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 

    210                 215                 220                 





Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 

225                 230                 235                 240 





Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 

                245                 250                 255     





Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 

            260                 265                 270         





Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 

        275                 280                 285             





Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 

    290                 295                 300                 





Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 

305                 310                 315                 320 





Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 

                325                 330                 335     





Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 

            340                 345                 350         





Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 

        355                 360                 365             





Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 

    370                 375                 380                 





Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 

385                 390                 395                 400 





Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 

                405                 410                 415     





Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 

            420                 425                 430         





Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 

        435                 440                 445             





Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 

    450                 455                 460                 





Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 

465                 470                 475                 480 





Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 

                485                 490                 495     





Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 

            500                 505                 510         





Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 

        515                 520                 525             





Ala Thr Pro Pro 

    530         





<210>  147

<211>  219

<212>  PRT

<213>  Homo sapiens



<400>  147



Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 

1               5                   10                  15      





Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 

            20                  25                  30          





Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 

        35                  40                  45              





Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 

    50                  55                  60                  





Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 

65                  70                  75                  80  





Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 

                85                  90                  95      





Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 

            100                 105                 110         





Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 

        115                 120                 125             





Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 

    130                 135                 140                 





Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 

145                 150                 155                 160 





Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 

                165                 170                 175     





Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 

            180                 185                 190         





Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 

        195                 200                 205             





Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 

    210                 215                 





<210>  148

<211>  359

<212>  PRT

<213>  Homo sapiens



<400>  148



Met Val Asp Met Asp Lys Leu Ile Asn Asn Leu Glu Val Gln Leu Asn 

1               5                   10                  15      





Ser Glu Gly Gly Ser Met Gln Val Phe Lys Gln Val Thr Ala Ser Val 

            20                  25                  30          





Arg Asn Arg Asp Pro Pro Glu Ile Glu Tyr Arg Ser Asn Met Thr Ser 

        35                  40                  45              





Pro Thr Leu Leu Asp Ala Asn Pro Met Glu Asn Pro Ala Leu Phe Asn 

    50                  55                  60                  





Asp Ile Lys Ile Glu Pro Pro Glu Glu Leu Leu Ala Ser Asp Phe Ser 

65                  70                  75                  80  





Leu Pro Gln Val Glu Pro Val Asp Leu Ser Phe His Lys Pro Lys Ala 

                85                  90                  95      





Pro Leu Gln Pro Ala Ser Met Leu Gln Ala Pro Ile Arg Pro Pro Lys 

            100                 105                 110         





Pro Gln Ser Ser Pro Gln Thr Leu Val Val Ser Thr Ser Thr Ser Asp 

        115                 120                 125             





Met Ser Thr Ser Ala Asn Ile Pro Thr Val Leu Thr Pro Gly Ser Val 

    130                 135                 140                 





Leu Thr Ser Ser Gln Ser Thr Gly Ser Gln Gln Ile Leu His Val Ile 

145                 150                 155                 160 





His Thr Ile Pro Ser Val Ser Leu Pro Asn Lys Met Gly Gly Leu Lys 

                165                 170                 175     





Thr Ile Pro Val Val Val Gln Ser Leu Pro Met Val Tyr Thr Thr Leu 

            180                 185                 190         





Pro Ala Asp Gly Gly Pro Ala Ala Ile Thr Val Pro Leu Ile Gly Gly 

        195                 200                 205             





Asp Gly Lys Asn Ala Gly Ser Val Lys Val Asp Pro Thr Ser Met Ser 

    210                 215                 220                 





Pro Leu Glu Ile Pro Ser Asp Ser Glu Glu Ser Thr Ile Glu Ser Gly 

225                 230                 235                 240 





Ser Ser Ala Leu Gln Ser Leu Gln Gly Leu Gln Gln Glu Pro Ala Ala 

                245                 250                 255     





Met Ala Gln Met Gln Gly Glu Glu Ser Leu Asp Leu Lys Arg Arg Arg 

            260                 265                 270         





Ile His Gln Cys Asp Phe Ala Gly Cys Ser Lys Val Tyr Thr Lys Ser 

        275                 280                 285             





Ser His Leu Lys Ala His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr 

    290                 295                 300                 





Lys Cys Thr Trp Asp Gly Cys Ser Trp Lys Phe Ala Arg Ser Asp Glu 

305                 310                 315                 320 





Leu Thr Arg His Phe Arg Lys His Thr Gly Ile Lys Pro Phe Arg Cys 

                325                 330                 335     





Thr Asp Cys Asn Arg Ser Phe Ser Arg Ser Asp His Leu Ser Leu His 

            340                 345                 350         





Arg Arg Arg His Asp Thr Met 

        355                 





<210>  149

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  149



Met Val Asp Met Asp Lys Leu Ile Asn Asn Leu Glu Val Gln Leu Asn 

1               5                   10                  15      





Ser Glu Gly Gly Ser Met Gln Val Phe Lys Gln Val Thr Ala Ser Val 

            20                  25                  30          





Arg Asn Arg Asp Pro Pro Glu Ile Glu Tyr Arg Ser Asn Met Thr Ser 

        35                  40                  45              





Pro Thr Leu Leu Asp Ala Asn Pro Met Glu Asn Pro Ala Leu Phe Asn 

    50                  55                  60                  





Asp Ile Lys Ile Glu Pro Pro Glu Glu Leu Leu Ala Ser Asp Phe Ser 

65                  70                  75                  80  





Leu Pro Gln Val Glu Pro Val Asp Leu Ser Phe His Lys Pro Lys Ala 

                85                  90                  95      





Pro Leu Gln Pro Ala Ser Met Leu Gln Ala Pro Ile Arg Pro Pro Lys 

            100                 105                 110         





Pro Gln Ser Ser Pro Gln Thr Leu Val Val Ser Thr Ser Thr Ser Asp 

        115                 120                 125             





Met Ser Thr Ser Ala Asn Ile Pro Thr Val Leu Thr Pro Gly Ser Val 

    130                 135                 140                 





Leu Thr Ser Ser Gln Ser Thr Gly Ser Gln Gln Ile Leu His Val Ile 

145                 150                 155                 160 





His Thr Ile Pro Ser Val Ser Leu Pro Asn Lys Met Gly Gly Leu Lys 

                165                 170                 175     





Thr Ile Pro Val Val Val Gln Ser Leu Pro Met Val Tyr Thr Thr Leu 

            180                 185                 190         





Pro Ala Asp Gly Gly Pro Ala Ala Ile Thr Val Pro Leu Ile Gly Gly 

        195                 200                 205             





Asp Gly Lys Asn Ala Gly Ser Val Lys Val Asp Pro Thr Ser Met Ser 

    210                 215                 220                 





Pro Leu Glu Ile Pro Ser Asp Ser Glu Glu Ser Thr Ile Glu Ser Gly 

225                 230                 235                 240 





Ser Ser Ala Leu Gln Ser Leu Gln Gly Leu Gln Gln Glu Arg Glu Ala 

                245                 250                 255     





Leu 

    





<210>  150

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  150



Met Ser Leu Pro Glu Asp Gly Met Ser Ser Gly His Phe Arg Ser Pro 

1               5                   10                  15      





Gln Leu Val Thr Trp Ser Val Thr Ala Ser Val Arg Asn Arg Asp Pro 

            20                  25                  30          





Pro Glu Ile Glu Tyr Arg Ser Asn Met Thr Ser Pro Thr Leu Leu Asp 

        35                  40                  45              





Ala Asn Pro Met Glu Asn Pro Ala Leu Phe Asn Asp Ile Lys Ile Glu 

    50                  55                  60                  





Pro Pro Glu Glu Leu Leu Ala Ser Asp Phe Ser Leu Pro Gln Val Glu 

65                  70                  75                  80  





Pro Val Asp Leu Ser Phe His Lys Pro Lys Ala Pro Leu Gln Pro Ala 

                85                  90                  95      





Ser Met Leu Gln Ala Pro Ile Arg Pro Pro Lys Pro Gln Ser Ser Pro 

            100                 105                 110         





Gln Thr Leu Val Val Ser Thr Ser Thr Ser Asp Met Ser Thr Ser Ala 

        115                 120                 125             





Asn Ile Pro Thr Val Leu Thr Pro Gly Ser Val Leu Thr Ser Ser Gln 

    130                 135                 140                 





Ser Thr Gly Ser Gln Gln Ile Leu His Val Ile His Thr Ile Pro Ser 

145                 150                 155                 160 





Val Ser Leu Pro Asn Lys Met Gly Gly Leu Lys Thr Ile Pro Val Val 

                165                 170                 175     





Val Gln Ser Leu Pro Met Val Tyr Thr Thr Leu Pro Ala Asp Gly Gly 

            180                 185                 190         





Pro Ala Ala Ile Thr Val Pro Leu Ile Gly Gly Asp Gly Lys Asn Ala 

        195                 200                 205             





Gly Ser Val Lys Val Asp Pro Thr Ser Met Ser Pro Leu Glu Ile Pro 

    210                 215                 220                 





Ser Asp Ser Glu Glu Ser Thr Ile Glu Ser Gly Ser Ser Ala Leu Gln 

225                 230                 235                 240 





Ser Leu Gln Gly Leu Gln Gln Glu Arg Glu Ala Leu 

                245                 250         





<210>  151

<211>  275

<212>  PRT

<213>  Homo sapiens



<400>  151



Met Val Asp Met Asp Lys Leu Ile Asn Asn Leu Glu Val Gln Leu Asn 

1               5                   10                  15      





Ser Glu Gly Gly Ser Met Gln Val Phe Lys Gln Val Thr Ala Ser Val 

            20                  25                  30          





Arg Asn Arg Asp Pro Pro Glu Ile Glu Tyr Arg Ser Asn Met Thr Ser 

        35                  40                  45              





Pro Thr Leu Leu Asp Ala Asn Pro Met Glu Asn Pro Ala Leu Phe Asn 

    50                  55                  60                  





Asp Ile Lys Ile Glu Pro Pro Glu Glu Leu Leu Ala Ser Asp Phe Ser 

65                  70                  75                  80  





Leu Pro Gln Val Glu Pro Val Asp Leu Ser Phe His Lys Pro Lys Ala 

                85                  90                  95      





Pro Leu Gln Pro Ala Ser Met Leu Gln Ala Pro Ile Arg Pro Pro Lys 

            100                 105                 110         





Pro Gln Ser Ser Pro Gln Thr Leu Val Val Ser Thr Ser Thr Ser Asp 

        115                 120                 125             





Met Ser Thr Ser Ala Asn Ile Pro Thr Val Leu Thr Pro Gly Ser Val 

    130                 135                 140                 





Leu Thr Ser Ser Gln Ser Thr Gly Ser Gln Gln Ile Leu His Val Ile 

145                 150                 155                 160 





His Thr Ile Pro Ser Val Ser Leu Pro Asn Lys Met Gly Gly Leu Lys 

                165                 170                 175     





Thr Ile Pro Val Val Val Gln Ser Leu Pro Met Val Tyr Thr Thr Leu 

            180                 185                 190         





Pro Ala Asp Gly Gly Pro Ala Ala Ile Thr Val Pro Leu Ile Gly Gly 

        195                 200                 205             





Asp Gly Lys Asn Ala Gly Ser Gly Glu Lys Pro Tyr Lys Cys Thr Trp 

    210                 215                 220                 





Asp Gly Cys Ser Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His 

225                 230                 235                 240 





Phe Arg Lys His Thr Gly Ile Lys Pro Phe Arg Cys Thr Asp Cys Asn 

                245                 250                 255     





Arg Ser Phe Ser Arg Ser Asp His Leu Ser Leu His Arg Arg Arg His 

            260                 265                 270         





Asp Thr Met 

        275 





<210>  152

<211>  323

<212>  PRT

<213>  Homo sapiens



<400>  152



Met Ala Tyr Val Pro Ala Pro Gly Tyr Gln Pro Thr Tyr Asn Pro Thr 

1               5                   10                  15      





Leu Pro Tyr Tyr Gln Pro Ile Pro Gly Gly Leu Asn Val Gly Met Ser 

            20                  25                  30          





Val Tyr Ile Gln Gly Val Ala Ser Glu His Met Lys Arg Phe Phe Val 

        35                  40                  45              





Asn Phe Val Val Gly Gln Asp Pro Gly Ser Asp Val Ala Phe His Phe 

    50                  55                  60                  





Asn Pro Arg Phe Asp Gly Trp Asp Lys Val Val Phe Asn Thr Leu Gln 

65                  70                  75                  80  





Gly Gly Lys Trp Gly Ser Glu Glu Arg Lys Arg Ser Met Pro Phe Lys 

                85                  90                  95      





Lys Gly Ala Ala Phe Glu Leu Val Phe Ile Val Leu Ala Glu His Tyr 

            100                 105                 110         





Lys Val Val Val Asn Gly Asn Pro Phe Tyr Glu Tyr Gly His Arg Leu 

        115                 120                 125             





Pro Leu Gln Met Val Thr His Leu Gln Val Asp Gly Asp Leu Gln Leu 

    130                 135                 140                 





Gln Ser Ile Asn Phe Ile Gly Gly Gln Pro Leu Arg Pro Gln Gly Pro 

145                 150                 155                 160 





Pro Met Met Pro Pro Tyr Pro Gly Pro Gly His Cys His Gln Gln Leu 

                165                 170                 175     





Asn Ser Leu Pro Thr Met Glu Gly Pro Pro Thr Phe Asn Pro Pro Val 

            180                 185                 190         





Pro Tyr Phe Gly Arg Leu Gln Gly Gly Leu Thr Ala Arg Arg Thr Ile 

        195                 200                 205             





Ile Ile Lys Gly Tyr Val Pro Pro Thr Gly Lys Ser Phe Ala Ile Asn 

    210                 215                 220                 





Phe Lys Val Gly Ser Ser Gly Asp Ile Ala Leu His Ile Asn Pro Arg 

225                 230                 235                 240 





Met Gly Asn Gly Thr Val Val Arg Asn Ser Leu Leu Asn Gly Ser Trp 

                245                 250                 255     





Gly Ser Glu Glu Lys Lys Ile Thr His Asn Pro Phe Gly Pro Gly Gln 

            260                 265                 270         





Phe Phe Asp Leu Ser Ile Arg Cys Gly Leu Asp Arg Phe Lys Val Tyr 

        275                 280                 285             





Ala Asn Gly Gln His Leu Phe Asp Phe Ala His Arg Leu Ser Ala Phe 

    290                 295                 300                 





Gln Arg Val Asp Thr Leu Glu Ile Gln Gly Asp Val Thr Leu Ser Tyr 

305                 310                 315                 320 





Val Gln Ile 

            





<210>  153

<211>  161

<212>  PRT

<213>  Homo sapiens



<400>  153



Met Gly Cys Cys Tyr Ser Ser Glu Asn Glu Asp Ser Asp Gln Asp Arg 

1               5                   10                  15      





Glu Glu Arg Lys Leu Leu Leu Asp Pro Ser Ser Pro Pro Thr Lys Ala 

            20                  25                  30          





Leu Asn Gly Ala Glu Pro Asn Tyr His Ser Leu Pro Ser Ala Arg Thr 

        35                  40                  45              





Asp Glu Gln Ala Leu Leu Ser Ser Ile Leu Ala Lys Thr Ala Ser Asn 

    50                  55                  60                  





Ile Ile Asp Val Ser Ala Ala Asp Ser Gln Gly Met Glu Gln His Glu 

65                  70                  75                  80  





Tyr Met Asp Arg Ala Arg Gln Tyr Ser Thr Arg Leu Ala Val Leu Ser 

                85                  90                  95      





Ser Ser Leu Thr His Trp Lys Lys Leu Pro Pro Leu Pro Ser Leu Thr 

            100                 105                 110         





Ser Gln Pro His Gln Val Leu Ala Ser Glu Pro Ile Pro Phe Ser Asp 

        115                 120                 125             





Leu Gln Gln Val Ser Arg Ile Ala Ala Tyr Ala Tyr Ser Ala Leu Ser 

    130                 135                 140                 





Gln Ile Arg Val Asp Ala Lys Glu Glu Leu Val Val Gln Phe Gly Ile 

145                 150                 155                 160 





Pro 

    





<210>  154

<211>  372

<212>  PRT

<213>  Homo sapiens



<400>  154



Met Ile Phe Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn 

1               5                   10                  15      





Ile Phe Lys Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala 

            20                  25                  30          





His His Gly Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met 

        35                  40                  45              





Asn Trp Gln Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu 

    50                  55                  60                  





Val Ala Ile Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu 

65                  70                  75                  80  





Pro Phe Ser Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly 

                85                  90                  95      





Ile Trp Thr Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu 

            100                 105                 110         





Asn Trp Gly Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys 

        115                 120                 125             





Val Glu Ile Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp 

    130                 135                 140                 





Asp Ala Cys His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys 

145                 150                 155                 160 





Gln Pro Trp Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn 

                165                 170                 175     





Asn Tyr Thr Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln 

            180                 185                 190         





Phe Val Ile Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met 

        195                 200                 205             





Asp Cys Thr His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala 

    210                 215                 220                 





Phe Ser Cys Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr 

225                 230                 235                 240 





Cys Gly Pro Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val 

                245                 250                 255     





Ile Gln Cys Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys 

            260                 265                 270         





Ser His Pro Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile 

        275                 280                 285             





Cys Ser Glu Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu 

    290                 295                 300                 





Ser Ser Gly Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp 

305                 310                 315                 320 





Lys Ser Phe Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile 

                325                 330                 335     





Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile 

            340                 345                 350         





Trp Leu Ala Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met 

        355                 360                 365             





Asn Asp Pro Tyr 

    370         





<210>  155

<211>  385

<212>  PRT

<213>  Homo sapiens



<400>  155



Met Gly Cys Arg Arg Thr Arg Glu Gly Pro Ser Lys Ala Met Ile Phe 

1               5                   10                  15      





Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn Ile Phe Lys 

            20                  25                  30          





Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala His His Gly 

        35                  40                  45              





Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met Asn Trp Gln 

    50                  55                  60                  





Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile 

65                  70                  75                  80  





Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu Pro Phe Ser 

                85                  90                  95      





Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly Ile Trp Thr 

            100                 105                 110         





Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu Asn Trp Gly 

        115                 120                 125             





Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys Val Glu Ile 

    130                 135                 140                 





Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp Asp Ala Cys 

145                 150                 155                 160 





His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys Gln Pro Trp 

                165                 170                 175     





Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn Asn Tyr Thr 

            180                 185                 190         





Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln Phe Val Ile 

        195                 200                 205             





Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met Asp Cys Thr 

    210                 215                 220                 





His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala Phe Ser Cys 

225                 230                 235                 240 





Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr Cys Gly Pro 

                245                 250                 255     





Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val Ile Gln Cys 

            260                 265                 270         





Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys Ser His Pro 

        275                 280                 285             





Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile Cys Ser Glu 

    290                 295                 300                 





Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu Ser Ser Gly 

305                 310                 315                 320 





Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp Lys Ser Phe 

                325                 330                 335     





Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala 

            340                 345                 350         





Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala 

        355                 360                 365             





Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro 

    370                 375                 380                 





Tyr 

385 





<210>  156

<211>  379

<212>  PRT

<213>  Homo sapiens



<400>  156



Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 

1               5                   10                  15      





Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 

            20                  25                  30          





Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 

        35                  40                  45              





Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 

    50                  55                  60                  





Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 

65                  70                  75                  80  





Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 

                85                  90                  95      





His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 

            100                 105                 110         





Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 

        115                 120                 125             





Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 

    130                 135                 140                 





Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 

145                 150                 155                 160 





Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 

                165                 170                 175     





Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 

            180                 185                 190         





Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 

        195                 200                 205             





Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 

    210                 215                 220                 





Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 

225                 230                 235                 240 





Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 

                245                 250                 255     





Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 

            260                 265                 270         





Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 

        275                 280                 285             





Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 

    290                 295                 300                 





Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 

305                 310                 315                 320 





Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 

                325                 330                 335     





Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 

            340                 345                 350         





Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 

        355                 360                 365             





Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 

    370                 375                 





<210>  157

<211>  335

<212>  PRT

<213>  Homo sapiens



<400>  157



Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 

1               5                   10                  15      





Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 

            20                  25                  30          





Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 

        35                  40                  45              





Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 

    50                  55                  60                  





Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 

65                  70                  75                  80  





Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 

                85                  90                  95      





His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 

            100                 105                 110         





Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 

        115                 120                 125             





Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 

    130                 135                 140                 





Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 

145                 150                 155                 160 





Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 

                165                 170                 175     





Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 

            180                 185                 190         





Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 

        195                 200                 205             





Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 

    210                 215                 220                 





Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 

225                 230                 235                 240 





Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 

                245                 250                 255     





Ile Leu Ala Leu Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn 

            260                 265                 270         





Lys Arg Ile Thr Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln 

        275                 280                 285             





Tyr Tyr Asp Pro Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe 

    290                 295                 300                 





Ala Met Glu Leu Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile 

305                 310                 315                 320 





Phe Gln Glu Thr Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 

                325                 330                 335 





<210>  158

<211>  357

<212>  PRT

<213>  Homo sapiens



<400>  158



Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 

1               5                   10                  15      





Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 

            20                  25                  30          





Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 

        35                  40                  45              





Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 

    50                  55                  60                  





Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 

65                  70                  75                  80  





Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 

                85                  90                  95      





His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 

            100                 105                 110         





Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 

        115                 120                 125             





Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 

    130                 135                 140                 





Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 

145                 150                 155                 160 





Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 

                165                 170                 175     





Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 

            180                 185                 190         





Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 

        195                 200                 205             





Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 

    210                 215                 220                 





Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 

225                 230                 235                 240 





Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 

                245                 250                 255     





Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 

            260                 265                 270         





Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 

        275                 280                 285             





Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 

    290                 295                 300                 





Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 

305                 310                 315                 320 





Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 

                325                 330                 335     





Thr Asp Glu Val Gly Gln Ser Pro Ala Ala Val Gly Leu Gly Ala Gly 

            340                 345                 350         





Glu Gln Gly Gly Thr 

        355         





<210>  159

<211>  5762

<212>  PRT

<213>  Homo sapiens



<400>  159



Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala 

1               5                   10                  15      





Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val Glu Pro Ser 

            20                  25                  30          





Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser 

        35                  40                  45              





Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser 

    50                  55                  60                  





Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp 

65                  70                  75                  80  





Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro 

                85                  90                  95      





Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu 

            100                 105                 110         





Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val 

        115                 120                 125             





Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser 

    130                 135                 140                 





Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser 

145                 150                 155                 160 





Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser 

                165                 170                 175     





Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu 

            180                 185                 190         





Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly 

        195                 200                 205             





Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala 

    210                 215                 220                 





Arg Leu Thr Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro 

225                 230                 235                 240 





Thr Glu Gln Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr 

                245                 250                 255     





Asp Glu Glu Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala 

            260                 265                 270         





Glu Cys His Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala 

        275                 280                 285             





Gln Asp Leu Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu 

    290                 295                 300                 





Tyr Ser Arg Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg 

305                 310                 315                 320 





Cys Pro Glu Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln 

                325                 330                 335     





Glu Cys Gly Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala 

            340                 345                 350         





Gln Leu Cys Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly 

        355                 360                 365             





Thr Val Leu Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly Gln 

    370                 375                 380                 





Cys Pro Cys Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe 

385                 390                 395                 400 





Asn Thr Thr Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys 

                405                 410                 415     





Gln Asp Leu Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala His 

            420                 425                 430         





Ile Ser Thr Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys Ser 

        435                 440                 445             





Tyr Val Leu Ser Lys Lys Cys Ala Asp Ser Ser Phe Thr Val Leu Ala 

    450                 455                 460                 





Glu Leu Arg Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala 

465                 470                 475                 480 





Val Thr Leu Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln Ala 

                485                 490                 495     





Asp Gly Gly Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser 

            500                 505                 510         





Ala Ala Asn Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val Val 

        515                 520                 525             





Gln Thr Gly Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu Met 

    530                 535                 540                 





Gln Val Phe Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys Gly 

545                 550                 555                 560 





Leu Cys Gly Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu 

                565                 570                 575     





Ser Gly Val Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys 

            580                 585                 590         





Ala Gln Ala Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys 

        595                 600                 605             





Ser Leu Ser Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser Arg 

    610                 615                 620                 





Leu Thr Asp Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile Asn 

625                 630                 635                 640 





Pro Lys Pro Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys Glu 

                645                 650                 655     





Arg Ser Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His Ala 

            660                 665                 670         





Cys Ala Ala Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val Cys 

        675                 680                 685             





Thr Lys Tyr Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val 

    690                 695                 700                 





Val Asp Ala Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp Val 

705                 710                 715                 720 





Thr Cys Ser Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro Ala 

                725                 730                 735     





Gly Thr Phe Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu Cys 

            740                 745                 750         





Pro Cys Tyr Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val His 

        755                 760                 765             





Asp Glu Gly Ala Val Cys Ser Cys Thr Gly Gly Lys Leu Ser Cys Leu 

    770                 775                 780                 





Gly Ala Ser Leu Gln Lys Ser Thr Gly Cys Ala Ala Pro Met Val Tyr 

785                 790                 795                 800 





Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro Gly Ala Glu Cys Leu 

                805                 810                 815     





Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe Ser Thr His Cys Val 

            820                 825                 830         





Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser Asp Gly Ser Gly Gly 

        835                 840                 845             





Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His Asn Glu Ala Thr Tyr 

    850                 855                 860                 





Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn Thr Cys Thr Cys Arg 

865                 870                 875                 880 





Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys Leu Gly Thr Cys Val 

                885                 890                 895     





Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp Gly Asp Arg Tyr Ser 

            900                 905                 910         





Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln Asp Tyr Cys Gly Asp 

        915                 920                 925             





Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr Glu Asn Ile Pro Cys 

    930                 935                 940                 





Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile Lys Leu Phe Val Glu 

945                 950                 955                 960 





Ser Tyr Glu Leu Ile Leu Gln Glu Gly Thr Phe Lys Ala Val Ala Arg 

                965                 970                 975     





Gly Pro Gly Gly Asp Pro Pro Tyr Lys Ile Arg Tyr Met Gly Ile Phe 

            980                 985                 990         





Leu Val Ile Glu Thr His Gly Met  Ala Val Ser Trp Asp  Arg Lys Thr 

        995                 1000                 1005             





Ser Val  Phe Ile Arg Leu His  Gln Asp Tyr Lys Gly  Arg Val Cys 

    1010                 1015                 1020             





Gly Leu  Cys Gly Asn Phe Asp  Asp Asn Ala Ile Asn  Asp Phe Ala 

    1025                 1030                 1035             





Thr Arg  Ser Arg Ser Val Val  Gly Asp Ala Leu Glu  Phe Gly Asn 

    1040                 1045                 1050             





Ser Trp  Lys Leu Ser Pro Ser  Cys Pro Asp Ala Leu  Ala Pro Lys 

    1055                 1060                 1065             





Asp Pro  Cys Thr Ala Asn Pro  Phe Arg Lys Ser Trp  Ala Gln Lys 

    1070                 1075                 1080             





Gln Cys  Ser Ile Leu His Gly  Pro Thr Phe Ala Ala  Cys Arg Ser 

    1085                 1090                 1095             





Gln Val  Asp Ser Thr Lys Tyr  Tyr Glu Ala Cys Val  Asn Asp Ala 

    1100                 1105                 1110             





Cys Ala  Cys Asp Ser Gly Gly  Asp Cys Glu Cys Phe  Cys Thr Ala 

    1115                 1120                 1125             





Val Ala  Ala Tyr Ala Gln Ala  Cys His Asp Ala Gly  Leu Cys Val 

    1130                 1135                 1140             





Ser Trp  Arg Thr Pro Asp Thr  Cys Pro Leu Phe Cys  Asp Phe Tyr 

    1145                 1150                 1155             





Asn Pro  His Gly Gly Cys Glu  Trp His Tyr Gln Pro  Cys Gly Ala 

    1160                 1165                 1170             





Pro Cys  Leu Lys Thr Cys Arg  Asn Pro Ser Gly His  Cys Leu Val 

    1175                 1180                 1185             





Asp Leu  Pro Gly Leu Glu Gly  Cys Tyr Pro Lys Cys  Pro Pro Ser 

    1190                 1195                 1200             





Gln Pro  Phe Phe Asn Glu Asp  Gln Met Lys Cys Val  Ala Gln Cys 

    1205                 1210                 1215             





Gly Cys  Tyr Asp Lys Asp Gly  Asn Tyr Tyr Asp Val  Gly Ala Arg 

    1220                 1225                 1230             





Val Pro  Thr Ala Glu Asn Cys  Gln Ser Cys Asn Cys  Thr Pro Ser 

    1235                 1240                 1245             





Gly Ile  Gln Cys Ala His Ser  Leu Glu Ala Cys Thr  Cys Thr Tyr 

    1250                 1255                 1260             





Glu Asp  Arg Thr Tyr Ser Tyr  Gln Asp Val Ile Tyr  Asn Thr Thr 

    1265                 1270                 1275             





Asp Gly  Leu Gly Ala Cys Leu  Ile Ala Ile Cys Gly  Ser Asn Gly 

    1280                 1285                 1290             





Thr Ile  Ile Arg Lys Ala Val  Ala Cys Pro Gly Thr  Pro Ala Thr 

    1295                 1300                 1305             





Thr Pro  Phe Thr Phe Thr Thr  Ala Trp Val Pro His  Ser Thr Thr 

    1310                 1315                 1320             





Ser Pro  Ala Leu Pro Val Ser  Thr Val Cys Val Arg  Glu Val Cys 

    1325                 1330                 1335             





Arg Trp  Ser Ser Trp Tyr Asn  Gly His Arg Pro Glu  Pro Gly Leu 

    1340                 1345                 1350             





Gly Gly  Gly Asp Phe Glu Thr  Phe Glu Asn Leu Arg  Gln Arg Gly 

    1355                 1360                 1365             





Tyr Gln  Val Cys Pro Val Leu  Ala Asp Ile Glu Cys  Arg Ala Ala 

    1370                 1375                 1380             





Gln Leu  Pro Asp Met Pro Leu  Glu Glu Leu Gly Gln  Gln Val Asp 

    1385                 1390                 1395             





Cys Asp  Arg Met Arg Gly Leu  Met Cys Ala Asn Ser  Gln Gln Ser 

    1400                 1405                 1410             





Pro Pro  Leu Cys His Asp Tyr  Glu Leu Arg Val Leu  Cys Cys Glu 

    1415                 1420                 1425             





Tyr Val  Pro Cys Gly Pro Ser  Pro Ala Pro Gly Thr  Ser Pro Gln 

    1430                 1435                 1440             





Pro Ser  Leu Ser Ala Ser Thr  Glu Pro Ala Val Pro  Thr Pro Thr 

    1445                 1450                 1455             





Gln Thr  Thr Ala Thr Glu Lys  Thr Thr Leu Trp Val  Thr Pro Ser 

    1460                 1465                 1470             





Ile Arg  Ser Thr Ala Ala Leu  Thr Ser Gln Thr Gly  Ser Ser Ser 

    1475                 1480                 1485             





Gly Pro  Val Thr Val Thr Pro  Ser Ala Pro Gly Thr  Thr Thr Cys 

    1490                 1495                 1500             





Gln Pro  Arg Cys Gln Trp Thr  Glu Trp Phe Asp Glu  Asp Tyr Pro 

    1505                 1510                 1515             





Lys Ser  Glu Gln Leu Gly Gly  Asp Val Glu Ser Tyr  Asp Lys Ile 

    1520                 1525                 1530             





Arg Ala  Ala Gly Gly His Leu  Cys Gln Gln Pro Lys  Asp Ile Glu 

    1535                 1540                 1545             





Cys Gln  Ala Glu Ser Phe Pro  Asn Trp Thr Leu Ala  Gln Val Gly 

    1550                 1555                 1560             





Gln Lys  Val His Cys Asp Val  His Phe Gly Leu Val  Cys Arg Asn 

    1565                 1570                 1575             





Trp Glu  Gln Glu Gly Val Phe  Lys Met Cys Tyr Asn  Tyr Arg Ile 

    1580                 1585                 1590             





Arg Val  Leu Cys Cys Ser Asp  Asp His Cys Arg Gly  Arg Ala Thr 

    1595                 1600                 1605             





Thr Pro  Pro Pro Thr Thr Glu  Leu Glu Thr Ala Thr  Thr Thr Thr 

    1610                 1615                 1620             





Thr Gln  Ala Leu Phe Ser Thr  Pro Gln Pro Thr Ser  Ser Pro Gly 

    1625                 1630                 1635             





Leu Thr  Arg Ala Pro Pro Ala  Ser Thr Thr Ala Val  Pro Thr Leu 

    1640                 1645                 1650             





Ser Glu  Gly Leu Thr Ser Pro  Arg Tyr Thr Ser Thr  Leu Gly Thr 

    1655                 1660                 1665             





Ala Thr  Thr Gly Gly Pro Thr  Thr Pro Ala Gly Ser  Thr Glu Pro 

    1670                 1675                 1680             





Thr Val  Pro Gly Val Ala Thr  Ser Thr Leu Pro Thr  Arg Ser Ala 

    1685                 1690                 1695             





Leu Pro  Gly Thr Thr Gly Ser  Leu Gly Thr Trp Arg  Pro Ser Gln 

    1700                 1705                 1710             





Pro Pro  Thr Leu Ala Pro Thr  Thr Met Ala Thr Ser  Arg Ala Arg 

    1715                 1720                 1725             





Pro Thr  Gly Thr Ala Ser Thr  Ala Ser Lys Glu Pro  Leu Thr Thr 

    1730                 1735                 1740             





Ser Leu  Ala Pro Thr Leu Thr  Ser Glu Leu Ser Thr  Ser Gln Ala 

    1745                 1750                 1755             





Glu Thr  Ser Thr Pro Arg Thr  Glu Thr Thr Met Ser  Pro Leu Thr 

    1760                 1765                 1770             





Asn Thr  Thr Thr Ser Gln Gly  Thr Thr Arg Cys Gln  Pro Lys Cys 

    1775                 1780                 1785             





Glu Trp  Thr Glu Trp Phe Asp  Val Asp Phe Pro Thr  Ser Gly Val 

    1790                 1795                 1800             





Ala Gly  Gly Asp Met Glu Thr  Phe Glu Asn Ile Arg  Ala Ala Gly 

    1805                 1810                 1815             





Gly Lys  Met Cys Trp Ala Pro  Lys Ser Ile Glu Cys  Arg Ala Glu 

    1820                 1825                 1830             





Asn Tyr  Pro Glu Val Ser Ile  Asp Gln Val Gly Gln  Val Leu Thr 

    1835                 1840                 1845             





Cys Ser  Leu Glu Thr Gly Leu  Thr Cys Lys Asn Glu  Asp Gln Thr 

    1850                 1855                 1860             





Gly Arg  Phe Asn Met Cys Phe  Asn Tyr Asn Val Arg  Val Leu Cys 

    1865                 1870                 1875             





Cys Asp  Asp Tyr Ser His Cys  Pro Ser Thr Pro Ala  Thr Ser Ser 

    1880                 1885                 1890             





Thr Ala  Thr Pro Ser Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr 

    1895                 1900                 1905             





Lys Pro  Thr Thr Thr Ala Thr  Thr Thr Ala Ser Thr  Gly Ser Thr 

    1910                 1915                 1920             





Ala Thr  Pro Thr Ser Thr Leu  Arg Thr Ala Pro Pro  Pro Lys Val 

    1925                 1930                 1935             





Leu Thr  Thr Thr Ala Thr Thr  Pro Thr Val Thr Ser  Ser Lys Ala 

    1940                 1945                 1950             





Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Thr Ala Leu  Pro Ala Leu 

    1955                 1960                 1965             





Arg Ser  Thr Ala Thr Thr Pro  Thr Ala Thr Ser Val  Thr Pro Ile 

    1970                 1975                 1980             





Pro Ser  Ser Ser Leu Gly Thr  Thr Trp Thr Arg Leu  Ser Gln Thr 

    1985                 1990                 1995             





Thr Thr  Pro Thr Ala Thr Met  Ser Thr Ala Thr Pro  Ser Ser Thr 

    2000                 2005                 2010             





Pro Glu  Thr Ala His Thr Ser  Thr Val Leu Thr Ala  Thr Ala Thr 

    2015                 2020                 2025             





Thr Thr  Gly Ala Thr Gly Ser  Val Ala Thr Pro Ser  Ser Thr Pro 

    2030                 2035                 2040             





Gly Thr  Ala His Thr Thr Lys  Val Pro Thr Thr Thr  Thr Thr Gly 

    2045                 2050                 2055             





Phe Thr  Ala Thr Pro Ser Ser  Ser Pro Gly Thr Ala  Leu Thr Pro 

    2060                 2065                 2070             





Pro Val  Trp Ile Ser Thr Thr  Thr Thr Pro Thr Thr  Arg Gly Ser 

    2075                 2080                 2085             





Thr Val  Thr Pro Ser Ser Ile  Pro Gly Thr Thr His  Thr Ala Thr 

    2090                 2095                 2100             





Val Leu  Thr Thr Thr Thr Thr  Thr Val Ala Thr Gly  Ser Met Ala 

    2105                 2110                 2115             





Thr Pro  Ser Ser Ser Thr Gln  Thr Ser Gly Thr Pro  Pro Ser Leu 

    2120                 2125                 2130             





Thr Thr  Thr Ala Thr Thr Ile  Thr Ala Thr Gly Ser  Thr Thr Asn 

    2135                 2140                 2145             





Pro Ser  Ser Thr Pro Gly Thr  Thr Pro Ile Pro Pro  Val Leu Thr 

    2150                 2155                 2160             





Thr Thr  Ala Thr Thr Pro Ala  Ala Thr Ser Asn Thr  Val Thr Pro 

    2165                 2170                 2175             





Ser Ser  Ala Leu Gly Thr Thr  His Thr Pro Pro Val  Pro Asn Thr 

    2180                 2185                 2190             





Met Ala  Thr Thr His Gly Arg  Ser Leu Pro Pro Ser  Ser Pro His 

    2195                 2200                 2205             





Thr Val  Arg Thr Ala Trp Thr  Ser Ala Thr Ser Gly  Ile Leu Gly 

    2210                 2215                 2220             





Thr Thr  His Ile Thr Glu Pro  Ser Thr Val Thr Ser  His Thr Leu 

    2225                 2230                 2235             





Ala Ala  Thr Thr Gly Thr Thr  Gln His Ser Thr Pro  Ala Leu Ser 

    2240                 2245                 2250             





Ser Pro  His Pro Ser Ser Arg  Thr Thr Glu Ser Pro  Pro Ser Pro 

    2255                 2260                 2265             





Gly Thr  Thr Thr Pro Gly His  Thr Thr Ala Thr Ser  Arg Thr Thr 

    2270                 2275                 2280             





Ala Thr  Ala Thr Pro Ser Lys  Thr Arg Thr Ser Thr  Leu Leu Pro 

    2285                 2290                 2295             





Ser Ser  Pro Thr Ser Ala Pro  Ile Thr Thr Val Val  Thr Met Gly 

    2300                 2305                 2310             





Cys Glu  Pro Gln Cys Ala Trp  Ser Glu Trp Leu Asp  Tyr Ser Tyr 

    2315                 2320                 2325             





Pro Met  Pro Gly Pro Ser Gly  Gly Asp Phe Asp Thr  Tyr Ser Asn 

    2330                 2335                 2340             





Ile Arg  Ala Ala Gly Gly Ala  Val Cys Glu Gln Pro  Leu Gly Leu 

    2345                 2350                 2355             





Glu Cys  Arg Ala Gln Ala Gln  Pro Gly Val Pro Leu  Arg Glu Leu 

    2360                 2365                 2370             





Gly Gln  Val Val Glu Cys Ser  Leu Asp Phe Gly Leu  Val Cys Arg 

    2375                 2380                 2385             





Asn Arg  Glu Gln Val Gly Lys  Phe Lys Met Cys Phe  Asn Tyr Glu 

    2390                 2395                 2400             





Ile Arg  Val Phe Cys Cys Asn  Tyr Gly His Cys Pro  Ser Thr Pro 

    2405                 2410                 2415             





Ala Thr  Ser Ser Thr Ala Met  Pro Ser Ser Thr Pro  Gly Thr Thr 

    2420                 2425                 2430             





Trp Ile  Leu Thr Glu Leu Thr  Thr Thr Ala Thr Thr  Thr Glu Ser 

    2435                 2440                 2445             





Thr Gly  Ser Thr Ala Thr Pro  Ser Ser Thr Pro Gly  Thr Thr Trp 

    2450                 2455                 2460             





Ile Leu  Thr Glu Pro Ser Thr  Thr Ala Thr Val Thr  Val Pro Thr 

    2465                 2470                 2475             





Gly Ser  Thr Ala Thr Ala Ser  Ser Thr Gln Ala Thr  Ala Gly Thr 

    2480                 2485                 2490             





Pro His  Val Ser Thr Thr Ala  Thr Thr Pro Thr Val  Thr Ser Ser 

    2495                 2500                 2505             





Lys Ala  Thr Pro Phe Ser Ser  Pro Gly Thr Ala Thr  Ala Leu Pro 

    2510                 2515                 2520             





Ala Leu  Arg Ser Thr Ala Thr  Thr Pro Thr Ala Thr  Ser Phe Thr 

    2525                 2530                 2535             





Ala Ile  Pro Ser Ser Ser Leu  Gly Thr Thr Trp Thr  Arg Leu Ser 

    2540                 2545                 2550             





Gln Thr  Thr Thr Pro Thr Ala  Thr Met Ser Thr Ala  Thr Pro Ser 

    2555                 2560                 2565             





Ser Thr  Pro Glu Thr Val His  Thr Ser Thr Val Leu  Thr Thr Thr 

    2570                 2575                 2580             





Ala Thr  Thr Thr Gly Ala Thr  Gly Ser Val Ala Thr  Pro Ser Ser 

    2585                 2590                 2595             





Thr Pro  Gly Thr Ala His Thr  Thr Lys Val Leu Thr  Thr Thr Thr 

    2600                 2605                 2610             





Thr Gly  Phe Thr Ala Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Arg 

    2615                 2620                 2625             





Thr Leu  Pro Val Trp Ile Ser  Thr Thr Thr Thr Pro  Thr Thr Arg 

    2630                 2635                 2640             





Gly Ser  Thr Val Thr Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr 

    2645                 2650                 2655             





Pro Thr  Val Leu Thr Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser 

    2660                 2665                 2670             





Met Ala  Thr Pro Ser Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro 

    2675                 2680                 2685             





Ser Leu  Thr Thr Thr Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr 

    2690                 2695                 2700             





Thr Asn  Pro Ser Ser Thr Pro  Gly Thr Thr Pro Ile  Pro Pro Val 

    2705                 2710                 2715             





Leu Thr  Thr Thr Ala Thr Thr  Pro Ala Ala Thr Ser  Ser Thr Val 

    2720                 2725                 2730             





Thr Pro  Ser Ser Ala Leu Gly  Thr Thr His Thr Pro  Pro Val Pro 

    2735                 2740                 2745             





Asn Thr  Thr Ala Thr Thr His  Gly Arg Ser Leu Ser  Pro Ser Ser 

    2750                 2755                 2760             





Pro His  Thr Val Arg Thr Ala  Trp Thr Ser Ala Thr  Ser Gly Thr 

    2765                 2770                 2775             





Leu Gly  Thr Thr His Ile Thr  Glu Pro Ser Thr Gly  Thr Ser His 

    2780                 2785                 2790             





Thr Pro  Ala Ala Thr Thr Gly  Thr Thr Gln His Ser  Thr Pro Ala 

    2795                 2800                 2805             





Leu Ser  Ser Pro His Pro Ser  Ser Arg Thr Thr Glu  Ser Pro Pro 

    2810                 2815                 2820             





Ser Pro  Gly Thr Thr Thr Pro  Gly His Thr Arg Ala  Thr Ser Arg 

    2825                 2830                 2835             





Thr Thr  Ala Thr Ala Thr Pro  Ser Lys Thr Arg Thr  Ser Thr Leu 

    2840                 2845                 2850             





Leu Pro  Ser Ser Pro Thr Ser  Ala Pro Ile Thr Thr  Val Val Thr 

    2855                 2860                 2865             





Met Gly  Cys Glu Pro Gln Cys  Ala Trp Ser Glu Trp  Leu Asp Tyr 

    2870                 2875                 2880             





Ser Tyr  Pro Met Pro Gly Pro  Ser Gly Gly Asp Phe  Asp Thr Tyr 

    2885                 2890                 2895             





Ser Asn  Ile Arg Ala Ala Gly  Gly Ala Val Cys Glu  Gln Pro Leu 

    2900                 2905                 2910             





Gly Leu  Glu Cys Arg Ala Gln  Ala Gln Pro Gly Val  Pro Leu Arg 

    2915                 2920                 2925             





Glu Leu  Gly Gln Val Val Glu  Cys Ser Leu Asp Phe  Gly Leu Val 

    2930                 2935                 2940             





Cys Arg  Asn Arg Glu Gln Val  Gly Lys Phe Lys Met  Cys Phe Asn 

    2945                 2950                 2955             





Tyr Glu  Ile Arg Val Phe Cys  Cys Asn Tyr Gly His  Cys Pro Ser 

    2960                 2965                 2970             





Thr Pro  Ala Thr Ser Ser Thr  Ala Thr Pro Ser Ser  Thr Pro Gly 

    2975                 2980                 2985             





Thr Thr  Trp Ile Leu Thr Glu  Gln Thr Thr Ala Ala  Thr Thr Thr 

    2990                 2995                 3000             





Ala Thr  Thr Gly Ser Thr Ala  Ile Pro Ser Ser Thr  Pro Gly Thr 

    3005                 3010                 3015             





Ala Pro  Pro Pro Lys Val Leu  Thr Ser Thr Ala Thr  Thr Pro Thr 

    3020                 3025                 3030             





Ala Thr  Ser Ser Lys Ala Thr  Ser Ser Ser Ser Pro  Arg Thr Ala 

    3035                 3040                 3045             





Thr Thr  Leu Pro Val Leu Thr  Ser Thr Ala Thr Lys  Ser Thr Ala 

    3050                 3055                 3060             





Thr Ser  Phe Thr Pro Ile Pro  Ser Phe Thr Leu Gly  Thr Thr Gly 

    3065                 3070                 3075             





Thr Leu  Pro Glu Gln Thr Thr  Thr Pro Met Ala Thr  Met Ser Thr 

    3080                 3085                 3090             





Ile His  Pro Ser Ser Thr Pro  Glu Thr Thr His Thr  Ser Thr Val 

    3095                 3100                 3105             





Leu Thr  Thr Lys Ala Thr Thr  Thr Arg Ala Thr Ser  Ser Met Ser 

    3110                 3115                 3120             





Thr Pro  Ser Ser Thr Pro Gly  Thr Thr Trp Ile Leu  Thr Glu Leu 

    3125                 3130                 3135             





Thr Thr  Ala Ala Thr Thr Thr  Ala Ala Thr Gly Pro  Thr Ala Thr 

    3140                 3145                 3150             





Pro Ser  Ser Thr Pro Gly Thr  Thr Trp Ile Leu Thr  Glu Pro Ser 

    3155                 3160                 3165             





Thr Thr  Ala Thr Val Thr Val  Pro Thr Gly Ser Thr  Ala Thr Ala 

    3170                 3175                 3180             





Ser Ser  Thr Arg Ala Thr Ala  Gly Thr Leu Lys Val  Leu Thr Ser 

    3185                 3190                 3195             





Thr Ala  Thr Thr Pro Thr Val  Ile Ser Ser Arg Ala  Thr Pro Ser 

    3200                 3205                 3210             





Ser Ser  Pro Gly Thr Ala Thr  Ala Leu Pro Ala Leu  Arg Ser Thr 

    3215                 3220                 3225             





Ala Thr  Thr Pro Thr Ala Thr  Ser Val Thr Ala Ile  Pro Ser Ser 

    3230                 3235                 3240             





Ser Leu  Gly Thr Ala Trp Thr  Arg Leu Ser Gln Thr  Thr Thr Pro 

    3245                 3250                 3255             





Thr Ala  Thr Met Ser Thr Ala  Thr Pro Ser Ser Thr  Pro Glu Thr 

    3260                 3265                 3270             





Val His  Thr Ser Thr Val Leu  Thr Thr Thr Thr Thr  Thr Thr Arg 

    3275                 3280                 3285             





Ala Thr  Gly Ser Val Ala Thr  Pro Ser Ser Thr Pro  Gly Thr Ala 

    3290                 3295                 3300             





His Thr  Thr Lys Val Pro Thr  Thr Thr Thr Thr Gly  Phe Thr Ala 

    3305                 3310                 3315             





Thr Pro  Ser Ser Ser Pro Gly  Thr Ala Leu Thr Pro  Pro Val Trp 

    3320                 3325                 3330             





Ile Ser  Thr Thr Thr Thr Pro  Thr Thr Arg Gly Ser  Thr Val Thr 

    3335                 3340                 3345             





Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr Ala Thr  Val Leu Thr 

    3350                 3355                 3360             





Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser Met Ala  Thr Pro Ser 

    3365                 3370                 3375             





Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro Ser Leu  Thr Thr Thr 

    3380                 3385                 3390             





Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr Thr Asn  Pro Ser Ser 

    3395                 3400                 3405             





Thr Pro  Gly Thr Thr Pro Ile  Pro Pro Val Leu Thr  Thr Thr Ala 

    3410                 3415                 3420             





Thr Thr  Pro Ala Ala Thr Ser  Ser Thr Val Thr Pro  Ser Ser Ala 

    3425                 3430                 3435             





Leu Gly  Thr Thr His Thr Pro  Pro Val Pro Asn Thr  Thr Ala Thr 

    3440                 3445                 3450             





Thr His  Gly Arg Ser Leu Pro  Pro Ser Ser Pro His  Thr Val Arg 

    3455                 3460                 3465             





Thr Ala  Trp Thr Ser Ala Thr  Ser Gly Ile Leu Gly  Thr Thr His 

    3470                 3475                 3480             





Ile Thr  Glu Pro Ser Thr Val  Thr Ser His Thr Pro  Ala Ala Thr 

    3485                 3490                 3495             





Thr Ser  Thr Thr Gln His Ser  Thr Pro Ala Leu Ser  Ser Pro His 

    3500                 3505                 3510             





Pro Ser  Ser Arg Thr Thr Glu  Ser Pro Pro Ser Pro  Gly Thr Thr 

    3515                 3520                 3525             





Thr Pro  Gly His Thr Arg Gly  Thr Ser Arg Thr Thr  Ala Thr Ala 

    3530                 3535                 3540             





Thr Pro  Ser Lys Thr Arg Thr  Ser Thr Leu Leu Pro  Ser Ser Pro 

    3545                 3550                 3555             





Thr Ser  Ala Pro Ile Thr Thr  Val Val Thr Thr Gly  Cys Glu Pro 

    3560                 3565                 3570             





Gln Cys  Ala Trp Ser Glu Trp  Leu Asp Tyr Ser Tyr  Pro Met Pro 

    3575                 3580                 3585             





Gly Pro  Ser Gly Gly Asp Phe  Asp Thr Tyr Ser Asn  Ile Arg Ala 

    3590                 3595                 3600             





Ala Gly  Gly Ala Val Cys Glu  Gln Pro Leu Gly Leu  Glu Cys Arg 

    3605                 3610                 3615             





Ala Gln  Ala Gln Pro Gly Val  Pro Leu Arg Glu Leu  Gly Gln Val 

    3620                 3625                 3630             





Val Glu  Cys Ser Leu Asp Phe  Gly Leu Val Cys Arg  Asn Arg Glu 

    3635                 3640                 3645             





Gln Val  Gly Lys Phe Lys Met  Cys Phe Asn Tyr Glu  Ile Arg Val 

    3650                 3655                 3660             





Phe Cys  Cys Asn Tyr Gly His  Cys Pro Ser Thr Pro  Ala Thr Ser 

    3665                 3670                 3675             





Ser Thr  Ala Thr Pro Ser Ser  Thr Pro Gly Thr Thr  Trp Ile Leu 

    3680                 3685                 3690             





Thr Lys  Leu Thr Thr Thr Ala  Thr Thr Thr Glu Ser  Thr Gly Ser 

    3695                 3700                 3705             





Thr Ala  Thr Pro Ser Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr 

    3710                 3715                 3720             





Glu Pro  Ser Thr Thr Ala Thr  Val Thr Val Pro Thr  Gly Ser Thr 

    3725                 3730                 3735             





Ala Thr  Ala Ser Ser Thr Gln  Ala Thr Ala Gly Thr  Pro His Val 

    3740                 3745                 3750             





Ser Thr  Thr Ala Thr Thr Pro  Thr Val Thr Ser Ser  Lys Ala Thr 

    3755                 3760                 3765             





Pro Phe  Ser Ser Pro Gly Thr  Ala Thr Ala Leu Pro  Ala Leu Arg 

    3770                 3775                 3780             





Ser Thr  Ala Thr Thr Pro Thr  Ala Thr Ser Phe Thr  Ala Ile Pro 

    3785                 3790                 3795             





Ser Ser  Ser Leu Gly Thr Thr  Trp Thr Arg Leu Ser  Gln Thr Thr 

    3800                 3805                 3810             





Thr Pro  Thr Ala Thr Met Ser  Thr Ala Thr Pro Ser  Ser Thr Pro 

    3815                 3820                 3825             





Glu Thr  Ala His Thr Ser Thr  Val Leu Thr Thr Thr  Ala Thr Thr 

    3830                 3835                 3840             





Thr Arg  Ala Thr Gly Ser Val  Ala Thr Pro Ser Ser  Thr Pro Gly 

    3845                 3850                 3855             





Thr Ala  His Thr Thr Lys Val  Pro Thr Thr Thr Thr  Thr Gly Phe 

    3860                 3865                 3870             





Thr Val  Thr Pro Ser Ser Ser  Pro Gly Thr Ala Arg  Thr Pro Pro 

    3875                 3880                 3885             





Val Trp  Ile Ser Thr Thr Thr  Thr Pro Thr Thr Ser  Gly Ser Thr 

    3890                 3895                 3900             





Val Thr  Pro Ser Ser Val Pro  Gly Thr Thr His Thr  Pro Thr Val 

    3905                 3910                 3915             





Leu Thr  Thr Thr Thr Thr Thr  Val Ala Thr Gly Ser  Met Ala Thr 

    3920                 3925                 3930             





Pro Ser  Ser Ser Thr Gln Thr  Ser Gly Thr Pro Pro  Ser Leu Ile 

    3935                 3940                 3945             





Thr Thr  Ala Thr Thr Ile Thr  Ala Thr Gly Ser Thr  Thr Asn Pro 

    3950                 3955                 3960             





Ser Ser  Thr Pro Gly Thr Thr  Pro Ile Pro Pro Val  Leu Thr Thr 

    3965                 3970                 3975             





Thr Ala  Thr Thr Pro Ala Ala  Thr Ser Ser Thr Val  Thr Pro Ser 

    3980                 3985                 3990             





Ser Ala  Leu Gly Thr Thr His  Thr Pro Pro Val Pro  Asn Thr Thr 

    3995                 4000                 4005             





Ala Thr  Thr His Gly Arg Ser  Leu Ser Pro Ser Ser  Pro His Thr 

    4010                 4015                 4020             





Val Arg  Thr Ala Trp Thr Ser  Ala Thr Ser Gly Thr  Leu Gly Thr 

    4025                 4030                 4035             





Thr His  Ile Thr Glu Pro Ser  Thr Gly Thr Ser His  Thr Pro Ala 

    4040                 4045                 4050             





Ala Thr  Thr Gly Thr Thr Gln  His Ser Thr Pro Ala  Leu Ser Ser 

    4055                 4060                 4065             





Pro His  Pro Ser Ser Arg Thr  Thr Glu Ser Pro Pro  Ser Pro Gly 

    4070                 4075                 4080             





Thr Thr  Thr Pro Gly His Thr  Thr Ala Thr Ser Arg  Thr Thr Ala 

    4085                 4090                 4095             





Thr Ala  Thr Pro Ser Lys Thr  Arg Thr Ser Thr Leu  Leu Pro Ser 

    4100                 4105                 4110             





Ser Pro  Thr Ser Ala Pro Ile  Thr Thr Val Val Thr  Thr Gly Cys 

    4115                 4120                 4125             





Glu Pro  Gln Cys Ala Trp Ser  Glu Trp Leu Asp Tyr  Ser Tyr Pro 

    4130                 4135                 4140             





Met Pro  Gly Pro Ser Gly Gly  Asp Phe Asp Thr Tyr  Ser Asn Ile 

    4145                 4150                 4155             





Arg Ala  Ala Gly Gly Ala Val  Cys Glu Gln Pro Leu  Gly Leu Glu 

    4160                 4165                 4170             





Cys Arg  Ala Gln Ala Gln Pro  Gly Val Pro Leu Gly  Glu Leu Gly 

    4175                 4180                 4185             





Gln Val  Val Glu Cys Ser Leu  Asp Phe Gly Leu Val  Cys Arg Asn 

    4190                 4195                 4200             





Arg Glu  Gln Val Gly Lys Phe  Lys Met Cys Phe Asn  Tyr Glu Ile 

    4205                 4210                 4215             





Arg Val  Phe Cys Cys Asn Tyr  Gly His Cys Pro Ser  Thr Pro Ala 

    4220                 4225                 4230             





Thr Ser  Ser Thr Ala Met Pro  Ser Ser Thr Pro Gly  Thr Thr Trp 

    4235                 4240                 4245             





Ile Leu  Thr Glu Leu Thr Thr  Thr Ala Thr Thr Thr  Ala Ser Thr 

    4250                 4255                 4260             





Gly Ser  Thr Ala Thr Pro Ser  Ser Thr Pro Gly Thr  Ala Pro Pro 

    4265                 4270                 4275             





Pro Lys  Val Leu Thr Ser Pro  Ala Thr Thr Pro Thr  Ala Thr Ser 

    4280                 4285                 4290             





Ser Lys  Ala Thr Ser Ser Ser  Ser Pro Arg Thr Ala  Thr Thr Leu 

    4295                 4300                 4305             





Pro Val  Leu Thr Ser Thr Ala  Thr Lys Ser Thr Ala  Thr Ser Val 

    4310                 4315                 4320             





Thr Pro  Ile Pro Ser Ser Thr  Leu Gly Thr Thr Gly  Thr Leu Pro 

    4325                 4330                 4335             





Glu Gln  Thr Thr Thr Pro Val  Ala Thr Met Ser Thr  Ile His Pro 

    4340                 4345                 4350             





Ser Ser  Thr Pro Glu Thr Thr  His Thr Ser Thr Val  Leu Thr Thr 

    4355                 4360                 4365             





Lys Ala  Thr Thr Thr Arg Ala  Thr Ser Ser Thr Ser  Thr Pro Ser 

    4370                 4375                 4380             





Ser Thr  Pro Gly Thr Thr Trp  Ile Leu Thr Glu Leu  Thr Thr Ala 

    4385                 4390                 4395             





Ala Thr  Thr Thr Ala Ala Thr  Gly Pro Thr Ala Thr  Pro Ser Ser 

    4400                 4405                 4410             





Thr Pro  Gly Thr Thr Trp Ile  Leu Thr Glu Leu Thr  Thr Thr Ala 

    4415                 4420                 4425             





Thr Thr  Thr Ala Ser Thr Gly  Ser Thr Ala Thr Pro  Ser Ser Thr 

    4430                 4435                 4440             





Pro Gly  Thr Thr Trp Ile Leu  Thr Glu Pro Ser Thr  Thr Ala Thr 

    4445                 4450                 4455             





Val Thr  Val Pro Thr Gly Ser  Thr Ala Thr Ala Ser  Ser Thr Gln 

    4460                 4465                 4470             





Ala Thr  Ala Gly Thr Pro His  Val Ser Thr Thr Ala  Thr Thr Pro 

    4475                 4480                 4485             





Thr Val  Thr Ser Ser Lys Ala  Thr Pro Ser Ser Ser  Pro Gly Thr 

    4490                 4495                 4500             





Ala Thr  Ala Leu Pro Ala Leu  Arg Ser Thr Ala Thr  Thr Pro Thr 

    4505                 4510                 4515             





Ala Thr  Ser Phe Thr Ala Ile  Pro Ser Ser Ser Leu  Gly Thr Thr 

    4520                 4525                 4530             





Trp Thr  Arg Leu Ser Gln Thr  Thr Thr Pro Thr Ala  Thr Met Ser 

    4535                 4540                 4545             





Thr Ala  Thr Pro Ser Ser Thr  Pro Glu Thr Val His  Thr Ser Thr 

    4550                 4555                 4560             





Val Leu  Thr Ala Thr Ala Thr  Thr Thr Gly Ala Thr  Gly Ser Val 

    4565                 4570                 4575             





Ala Thr  Pro Ser Ser Thr Pro  Gly Thr Ala His Thr  Thr Lys Val 

    4580                 4585                 4590             





Pro Thr  Thr Thr Thr Thr Gly  Phe Thr Ala Thr Pro  Ser Ser Ser 

    4595                 4600                 4605             





Pro Gly  Thr Ala Leu Thr Pro  Pro Val Trp Ile Ser  Thr Thr Thr 

    4610                 4615                 4620             





Thr Pro  Thr Thr Thr Thr Pro  Thr Thr Ser Gly Ser  Thr Val Thr 

    4625                 4630                 4635             





Pro Ser  Ser Ile Pro Gly Thr  Thr His Thr Ala Arg  Val Leu Thr 

    4640                 4645                 4650             





Thr Thr  Thr Thr Thr Val Ala  Thr Gly Ser Met Ala  Thr Pro Ser 

    4655                 4660                 4665             





Ser Ser  Thr Gln Thr Ser Gly  Thr Pro Pro Ser Leu  Thr Thr Thr 

    4670                 4675                 4680             





Ala Thr  Thr Ile Thr Ala Thr  Gly Ser Thr Thr Asn  Pro Ser Ser 

    4685                 4690                 4695             





Thr Pro  Gly Thr Thr Pro Ile  Thr Pro Val Leu Thr  Ser Thr Ala 

    4700                 4705                 4710             





Thr Thr  Pro Ala Ala Thr Ser  Ser Lys Ala Thr Ser  Ser Ser Ser 

    4715                 4720                 4725             





Pro Arg  Thr Ala Thr Thr Leu  Pro Val Leu Thr Ser  Thr Ala Thr 

    4730                 4735                 4740             





Lys Ser  Thr Ala Thr Ser Phe  Thr Pro Ile Pro Ser  Ser Thr Leu 

    4745                 4750                 4755             





Trp Thr  Thr Trp Thr Val Pro  Ala Gln Thr Thr Thr  Pro Met Ser 

    4760                 4765                 4770             





Thr Met  Ser Thr Ile His Thr  Ser Ser Thr Pro Glu  Thr Thr His 

    4775                 4780                 4785             





Thr Ser  Thr Val Leu Thr Thr  Thr Ala Thr Met Thr  Arg Ala Thr 

    4790                 4795                 4800             





Asn Ser  Thr Ala Thr Pro Ser  Ser Thr Leu Gly Thr  Thr Arg Ile 

    4805                 4810                 4815             





Leu Thr  Glu Leu Thr Thr Thr  Ala Thr Thr Thr Ala  Ala Thr Gly 

    4820                 4825                 4830             





Ser Thr  Ala Thr Leu Ser Ser  Thr Pro Gly Thr Thr  Trp Ile Leu 

    4835                 4840                 4845             





Thr Glu  Pro Ser Thr Ile Ala  Thr Val Met Val Pro  Thr Gly Ser 

    4850                 4855                 4860             





Thr Ala  Thr Ala Ser Ser Thr  Leu Gly Thr Ala His  Thr Pro Lys 

    4865                 4870                 4875             





Val Val  Thr Thr Met Ala Thr  Met Pro Thr Ala Thr  Ala Ser Thr 

    4880                 4885                 4890             





Val Pro  Ser Ser Ser Thr Val  Gly Thr Thr Arg Thr  Pro Ala Val 

    4895                 4900                 4905             





Leu Pro  Ser Ser Leu Pro Thr  Phe Ser Val Ser Thr  Val Ser Ser 

    4910                 4915                 4920             





Ser Val  Leu Thr Thr Leu Arg  Pro Thr Gly Phe Pro  Ser Ser His 

    4925                 4930                 4935             





Phe Ser  Thr Pro Cys Phe Cys  Arg Ala Phe Gly Gln  Phe Phe Ser 

    4940                 4945                 4950             





Pro Gly  Glu Val Ile Tyr Asn  Lys Thr Asp Arg Ala  Gly Cys His 

    4955                 4960                 4965             





Phe Tyr  Ala Val Cys Asn Gln  His Cys Asp Ile Asp  Arg Phe Gln 

    4970                 4975                 4980             





Gly Ala  Cys Pro Thr Ser Pro  Pro Pro Val Ser Ser  Ala Pro Leu 

    4985                 4990                 4995             





Ser Ser  Pro Ser Pro Ala Pro  Gly Cys Asp Asn Ala  Ile Pro Leu 

    5000                 5005                 5010             





Arg Gln  Val Asn Glu Thr Trp  Thr Leu Glu Asn Cys  Thr Val Ala 

    5015                 5020                 5025             





Arg Cys  Val Gly Asp Asn Arg  Val Val Leu Leu Asp  Pro Lys Pro 

    5030                 5035                 5040             





Val Ala  Asn Val Thr Cys Val  Asn Lys His Leu Pro  Ile Lys Val 

    5045                 5050                 5055             





Ser Asp  Pro Ser Gln Pro Cys  Asp Phe His Tyr Glu  Cys Glu Cys 

    5060                 5065                 5070             





Ile Cys  Ser Met Trp Gly Gly  Ser His Tyr Ser Thr  Phe Asp Gly 

    5075                 5080                 5085             





Thr Ser  Tyr Thr Phe Arg Gly  Asn Cys Thr Tyr Val  Leu Met Arg 

    5090                 5095                 5100             





Glu Ile  His Ala Arg Phe Gly  Asn Leu Ser Leu Tyr  Leu Asp Asn 

    5105                 5110                 5115             





His Tyr  Cys Thr Ala Ser Ala  Thr Ala Ala Ala Ala  Arg Cys Pro 

    5120                 5125                 5130             





Arg Ala  Leu Ser Ile His Tyr  Lys Ser Met Asp Ile  Val Leu Thr 

    5135                 5140                 5145             





Val Thr  Met Val His Gly Lys  Glu Glu Gly Leu Ile  Leu Phe Asp 

    5150                 5155                 5160             





Gln Ile  Pro Val Ser Ser Gly  Phe Ser Lys Asn Gly  Val Leu Val 

    5165                 5170                 5175             





Ser Val  Leu Gly Thr Thr Thr  Met Arg Val Asp Ile  Pro Ala Leu 

    5180                 5185                 5190             





Gly Val  Ser Val Thr Phe Asn  Gly Gln Val Phe Gln  Ala Arg Leu 

    5195                 5200                 5205             





Pro Tyr  Ser Leu Phe His Asn  Asn Thr Glu Gly Gln  Cys Gly Thr 

    5210                 5215                 5220             





Cys Thr  Asn Asn Gln Arg Asp  Asp Cys Leu Gln Arg  Asp Gly Thr 

    5225                 5230                 5235             





Thr Ala  Ala Ser Cys Lys Asp  Met Ala Lys Thr Trp  Leu Val Pro 

    5240                 5245                 5250             





Asp Ser  Arg Lys Asp Gly Cys  Trp Ala Pro Thr Gly  Thr Pro Pro 

    5255                 5260                 5265             





Thr Ala  Ser Pro Ala Ala Pro  Val Ser Ser Thr Pro  Thr Pro Thr 

    5270                 5275                 5280             





Pro Cys  Pro Pro Gln Pro Leu  Cys Asp Leu Met Leu  Ser Gln Val 

    5285                 5290                 5295             





Phe Ala  Glu Cys His Asn Leu  Val Pro Pro Gly Pro  Phe Phe Asn 

    5300                 5305                 5310             





Ala Cys  Ile Ser Asp His Cys  Arg Gly Arg Leu Glu  Val Pro Cys 

    5315                 5320                 5325             





Gln Ser  Leu Glu Ala Tyr Ala  Glu Leu Cys Arg Ala  Arg Gly Val 

    5330                 5335                 5340             





Cys Ser  Asp Trp Arg Gly Ala  Thr Gly Gly Leu Cys  Asp Leu Thr 

    5345                 5350                 5355             





Cys Pro  Pro Thr Lys Val Tyr  Lys Pro Cys Gly Pro  Ile Gln Pro 

    5360                 5365                 5370             





Ala Thr  Cys Asn Ser Arg Asn  Gln Ser Pro Gln Leu  Glu Gly Met 

    5375                 5380                 5385             





Ala Glu  Gly Cys Phe Cys Pro  Glu Asp Gln Ile Leu  Phe Asn Ala 

    5390                 5395                 5400             





His Met  Gly Ile Cys Val Gln  Ala Cys Pro Cys Val  Gly Pro Asp 

    5405                 5410                 5415             





Gly Phe  Pro Lys Phe Pro Gly  Glu Arg Trp Val Ser  Asn Cys Gln 

    5420                 5425                 5430             





Ser Cys  Val Cys Asp Glu Gly  Ser Val Ser Val Gln  Cys Lys Pro 

    5435                 5440                 5445             





Leu Pro  Cys Asp Ala Gln Gly  Gln Pro Pro Pro Cys  Asn Arg Pro 

    5450                 5455                 5460             





Gly Phe  Val Thr Val Thr Arg  Pro Arg Ala Glu Asn  Pro Cys Cys 

    5465                 5470                 5475             





Pro Glu  Thr Val Cys Val Cys  Asn Thr Thr Thr Cys  Pro Gln Ser 

    5480                 5485                 5490             





Leu Pro  Val Cys Pro Pro Gly  Gln Glu Ser Ile Cys  Thr Gln Glu 

    5495                 5500                 5505             





Glu Gly  Asp Cys Cys Pro Thr  Phe Arg Cys Arg Pro  Gln Leu Cys 

    5510                 5515                 5520             





Ser Tyr  Asn Gly Thr Phe Tyr  Gly Val Gly Ala Thr  Phe Pro Gly 

    5525                 5530                 5535             





Ala Leu  Pro Cys His Met Cys  Thr Cys Leu Ser Gly  Asp Thr Gln 

    5540                 5545                 5550             





Asp Pro  Thr Val Gln Cys Gln  Glu Asp Ala Cys Asn  Asn Thr Thr 

    5555                 5560                 5565             





Cys Pro  Gln Gly Phe Glu Tyr  Lys Arg Val Ala Gly  Gln Cys Cys 

    5570                 5575                 5580             





Gly Glu  Cys Val Gln Thr Ala  Cys Leu Thr Pro Asp  Gly Gln Pro 

    5585                 5590                 5595             





Val Gln  Leu Asn Glu Thr Trp  Val Asn Ser His Val  Asp Asn Cys 

    5600                 5605                 5610             





Thr Val  Tyr Leu Cys Glu Ala  Glu Gly Gly Val His  Leu Leu Thr 

    5615                 5620                 5625             





Pro Gln  Pro Ala Ser Cys Pro  Asp Val Ser Ser Cys  Arg Gly Ser 

    5630                 5635                 5640             





Leu Arg  Lys Thr Gly Cys Cys  Tyr Ser Cys Glu Glu  Asp Ser Cys 

    5645                 5650                 5655             





Gln Val  Arg Ile Asn Thr Thr  Ile Leu Trp His Gln  Gly Cys Glu 

    5660                 5665                 5670             





Thr Glu  Val Asn Ile Thr Phe  Cys Glu Gly Ser Cys  Pro Gly Ala 

    5675                 5680                 5685             





Ser Lys  Tyr Ser Ala Glu Ala  Gln Ala Met Gln His  Gln Cys Thr 

    5690                 5695                 5700             





Cys Cys  Gln Glu Arg Arg Val  His Glu Glu Thr Val  Pro Leu His 

    5705                 5710                 5715             





Cys Pro  Asn Gly Ser Ala Ile  Leu His Thr Tyr Thr  His Val Asp 

    5720                 5725                 5730             





Glu Cys  Gly Cys Thr Pro Phe  Cys Val Pro Ala Pro  Met Ala Pro 

    5735                 5740                 5745             





Pro His  Thr Arg Gly Phe Pro  Ala Gln Glu Ala Thr  Ala Val 

    5750                 5755                 5760         





<210>  160

<211>  902

<212>  PRT

<213>  Homo sapiens



<400>  160



Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

1               5                   10                  15      





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

            20                  25                  30          





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

        35                  40                  45              





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

    50                  55                  60                  





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

65                  70                  75                  80  





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

                85                  90                  95      





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

            100                 105                 110         





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

        115                 120                 125             





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

    130                 135                 140                 





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

145                 150                 155                 160 





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

                165                 170                 175     





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

            180                 185                 190         





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

        195                 200                 205             





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

    210                 215                 220                 





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

225                 230                 235                 240 





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

                245                 250                 255     





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

            260                 265                 270         





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

        275                 280                 285             





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

    290                 295                 300                 





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

305                 310                 315                 320 





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

                325                 330                 335     





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

            340                 345                 350         





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

        355                 360                 365             





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

    370                 375                 380                 





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

385                 390                 395                 400 





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

                405                 410                 415     





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

            420                 425                 430         





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

        435                 440                 445             





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

    450                 455                 460                 





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

465                 470                 475                 480 





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

                485                 490                 495     





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

            500                 505                 510         





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

        515                 520                 525             





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

    530                 535                 540                 





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

545                 550                 555                 560 





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

                565                 570                 575     





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

            580                 585                 590         





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

        595                 600                 605             





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

    610                 615                 620                 





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

625                 630                 635                 640 





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

                645                 650                 655     





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

            660                 665                 670         





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

        675                 680                 685             





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

    690                 695                 700                 





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

705                 710                 715                 720 





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

                725                 730                 735     





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

            740                 745                 750         





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

        755                 760                 765             





Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro 

    770                 775                 780                 





Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser 

785                 790                 795                 800 





Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu 

                805                 810                 815     





Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val 

            820                 825                 830         





His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly 

        835                 840                 845             





Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser 

    850                 855                 860                 





Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu 

865                 870                 875                 880 





Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro 

                885                 890                 895     





Gly Glu Glu Pro Pro Ala 

            900         





<210>  161

<211>  965

<212>  PRT

<213>  Homo sapiens



<400>  161



Met Ile Thr Thr Leu Pro Ser Leu Leu Pro Ala Ser Leu Ala Ser Ile 

1               5                   10                  15      





Ser His Arg Val Thr Asn Leu Pro Ser Asn Ser Leu Ser His Asn Pro 

            20                  25                  30          





Gly Leu Ser Lys Pro Asp Phe Pro Gly Asn Ser Ser Pro Gly Leu Pro 

        35                  40                  45              





Ser Ser Ser Ser Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met 

    50                  55                  60                  





Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe 

65                  70                  75                  80  





Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu 

                85                  90                  95      





Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly 

            100                 105                 110         





Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro 

        115                 120                 125             





Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser 

    130                 135                 140                 





Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly 

145                 150                 155                 160 





Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys 

                165                 170                 175     





Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala 

            180                 185                 190         





Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp 

        195                 200                 205             





Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln 

    210                 215                 220                 





Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser 

225                 230                 235                 240 





Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala 

                245                 250                 255     





Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe 

            260                 265                 270         





Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp 

        275                 280                 285             





Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg 

    290                 295                 300                 





Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro 

305                 310                 315                 320 





Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser 

                325                 330                 335     





Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser 

            340                 345                 350         





Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu 

        355                 360                 365             





Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro 

    370                 375                 380                 





Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln 

385                 390                 395                 400 





Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys 

                405                 410                 415     





Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg 

            420                 425                 430         





Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala 

        435                 440                 445             





Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser 

    450                 455                 460                 





Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu 

465                 470                 475                 480 





Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr 

                485                 490                 495     





Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His 

            500                 505                 510         





Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln 

        515                 520                 525             





Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

    530                 535                 540                 





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

545                 550                 555                 560 





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

                565                 570                 575     





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

            580                 585                 590         





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

        595                 600                 605             





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

    610                 615                 620                 





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

625                 630                 635                 640 





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

                645                 650                 655     





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

            660                 665                 670         





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

        675                 680                 685             





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

    690                 695                 700                 





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

705                 710                 715                 720 





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

                725                 730                 735     





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

            740                 745                 750         





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

        755                 760                 765             





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

    770                 775                 780                 





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

785                 790                 795                 800 





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

                805                 810                 815     





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

            820                 825                 830         





Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg 

        835                 840                 845             





Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu 

    850                 855                 860                 





Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro 

865                 870                 875                 880 





Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His 

                885                 890                 895     





Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro 

            900                 905                 910         





Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser 

        915                 920                 925             





Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Val 

    930                 935                 940                 





Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro Gly 

945                 950                 955                 960 





Glu Glu Pro Pro Ala 

                965 





<210>  162

<211>  964

<212>  PRT

<213>  Homo sapiens



<400>  162



Met Ile Thr Thr Leu Pro Ser Leu Leu Pro Ala Ser Leu Ala Ser Ile 

1               5                   10                  15      





Ser His Arg Val Thr Asn Leu Pro Ser Asn Ser Leu Ser His Asn Pro 

            20                  25                  30          





Gly Leu Ser Lys Pro Asp Phe Pro Gly Asn Ser Ser Pro Gly Leu Pro 

        35                  40                  45              





Ser Ser Ser Ser Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met 

    50                  55                  60                  





Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe 

65                  70                  75                  80  





Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu 

                85                  90                  95      





Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly 

            100                 105                 110         





Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro 

        115                 120                 125             





Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser 

    130                 135                 140                 





Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly 

145                 150                 155                 160 





Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys 

                165                 170                 175     





Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala 

            180                 185                 190         





Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp 

        195                 200                 205             





Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln 

    210                 215                 220                 





Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser 

225                 230                 235                 240 





Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala 

                245                 250                 255     





Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe 

            260                 265                 270         





Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp 

        275                 280                 285             





Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg 

    290                 295                 300                 





Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro 

305                 310                 315                 320 





Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser 

                325                 330                 335     





Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser 

            340                 345                 350         





Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu 

        355                 360                 365             





Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro 

    370                 375                 380                 





Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln 

385                 390                 395                 400 





Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys 

                405                 410                 415     





Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg 

            420                 425                 430         





Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala 

        435                 440                 445             





Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser 

    450                 455                 460                 





Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu 

465                 470                 475                 480 





Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr 

                485                 490                 495     





Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His 

            500                 505                 510         





Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln 

        515                 520                 525             





Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

    530                 535                 540                 





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

545                 550                 555                 560 





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

                565                 570                 575     





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

            580                 585                 590         





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

        595                 600                 605             





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

    610                 615                 620                 





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

625                 630                 635                 640 





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

                645                 650                 655     





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

            660                 665                 670         





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

        675                 680                 685             





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

    690                 695                 700                 





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

705                 710                 715                 720 





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

                725                 730                 735     





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

            740                 745                 750         





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

        755                 760                 765             





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

    770                 775                 780                 





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

785                 790                 795                 800 





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

                805                 810                 815     





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

            820                 825                 830         





Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg 

        835                 840                 845             





Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu 

    850                 855                 860                 





Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro 

865                 870                 875                 880 





Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His 

                885                 890                 895     





Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro 

            900                 905                 910         





Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser 

        915                 920                 925             





Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Gly 

    930                 935                 940                 





Gly Cys Gly Thr Gly Gly Cys Glu Cys Glu Cys Val Gln Glu Ile Ala 

945                 950                 955                 960 





Leu His Val Cys 

                





<210>  163

<211>  934

<212>  PRT

<213>  Homo sapiens



<400>  163



Met Ala Asp Gly Gly Ala Asp Ser Ala Ala Gln Arg Leu Pro Glu Gly 

1               5                   10                  15      





Pro Gly Arg Val Ala Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser 

            20                  25                  30          





Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

        35                  40                  45              





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

    50                  55                  60                  





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

65                  70                  75                  80  





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

                85                  90                  95      





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

            100                 105                 110         





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

        115                 120                 125             





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

    130                 135                 140                 





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

145                 150                 155                 160 





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

                165                 170                 175     





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

            180                 185                 190         





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

        195                 200                 205             





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

    210                 215                 220                 





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

225                 230                 235                 240 





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

                245                 250                 255     





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

            260                 265                 270         





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

        275                 280                 285             





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

    290                 295                 300                 





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

305                 310                 315                 320 





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

                325                 330                 335     





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

            340                 345                 350         





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

        355                 360                 365             





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

    370                 375                 380                 





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

385                 390                 395                 400 





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

                405                 410                 415     





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

            420                 425                 430         





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

        435                 440                 445             





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

    450                 455                 460                 





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

465                 470                 475                 480 





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

                485                 490                 495     





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

            500                 505                 510         





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

        515                 520                 525             





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

    530                 535                 540                 





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

545                 550                 555                 560 





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

                565                 570                 575     





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

            580                 585                 590         





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

        595                 600                 605             





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

    610                 615                 620                 





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

625                 630                 635                 640 





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

                645                 650                 655     





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

            660                 665                 670         





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

        675                 680                 685             





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

    690                 695                 700                 





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

705                 710                 715                 720 





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

                725                 730                 735     





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

            740                 745                 750         





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

        755                 760                 765             





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

    770                 775                 780                 





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

785                 790                 795                 800 





Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro 

                805                 810                 815     





Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser 

            820                 825                 830         





Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu 

        835                 840                 845             





Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val 

    850                 855                 860                 





His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly 

865                 870                 875                 880 





Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser 

                885                 890                 895     





Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu 

            900                 905                 910         





Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro 

        915                 920                 925             





Gly Glu Glu Pro Pro Ala 

    930                 





<210>  164

<211>  933

<212>  PRT

<213>  Homo sapiens



<400>  164



Met Ala Asp Gly Gly Ala Asp Ser Ala Ala Gln Arg Leu Pro Glu Gly 

1               5                   10                  15      





Pro Gly Arg Val Ala Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser 

            20                  25                  30          





Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

        35                  40                  45              





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

    50                  55                  60                  





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

65                  70                  75                  80  





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

                85                  90                  95      





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

            100                 105                 110         





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

        115                 120                 125             





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

    130                 135                 140                 





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

145                 150                 155                 160 





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

                165                 170                 175     





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

            180                 185                 190         





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

        195                 200                 205             





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

    210                 215                 220                 





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

225                 230                 235                 240 





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

                245                 250                 255     





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

            260                 265                 270         





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

        275                 280                 285             





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

    290                 295                 300                 





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

305                 310                 315                 320 





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

                325                 330                 335     





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

            340                 345                 350         





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

        355                 360                 365             





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

    370                 375                 380                 





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

385                 390                 395                 400 





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

                405                 410                 415     





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

            420                 425                 430         





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

        435                 440                 445             





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

    450                 455                 460                 





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

465                 470                 475                 480 





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

                485                 490                 495     





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

            500                 505                 510         





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

        515                 520                 525             





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

    530                 535                 540                 





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

545                 550                 555                 560 





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

                565                 570                 575     





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

            580                 585                 590         





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

        595                 600                 605             





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

    610                 615                 620                 





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

625                 630                 635                 640 





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

                645                 650                 655     





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

            660                 665                 670         





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

        675                 680                 685             





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

    690                 695                 700                 





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

705                 710                 715                 720 





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

                725                 730                 735     





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

            740                 745                 750         





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

        755                 760                 765             





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

    770                 775                 780                 





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

785                 790                 795                 800 





Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro 

                805                 810                 815     





Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser 

            820                 825                 830         





Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu 

        835                 840                 845             





Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val 

    850                 855                 860                 





His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly 

865                 870                 875                 880 





Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser 

                885                 890                 895     





Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu 

            900                 905                 910         





Gly Gly Cys Gly Thr Gly Gly Cys Glu Cys Glu Cys Val Gln Glu Ile 

        915                 920                 925             





Ala Leu His Val Cys 

    930             





<210>  165

<211>  915

<212>  PRT

<213>  Homo sapiens



<400>  165



Met Leu Ser Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met Gly Ala 

1               5                   10                  15      





Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe Gly Glu 

            20                  25                  30          





Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu Glu Leu 

        35                  40                  45              





Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly Glu Pro 

    50                  55                  60                  





Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro Pro Pro 

65                  70                  75                  80  





Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser Pro Gly 

                85                  90                  95      





Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly Pro Gly 

            100                 105                 110         





Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys Pro Ser 

        115                 120                 125             





Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala Ala Leu 

    130                 135                 140                 





Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp Tyr Pro 

145                 150                 155                 160 





Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln Gly Gly 

                165                 170                 175     





Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser Ser Trp 

            180                 185                 190         





Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala Ala Cys 

        195                 200                 205             





Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe Gly Leu 

    210                 215                 220                 





Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp Thr Pro 

225                 230                 235                 240 





Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg Gly Pro 

                245                 250                 255     





Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro Ala Ser 

            260                 265                 270         





Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser Ser Gly 

        275                 280                 285             





Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser Leu Gly 

    290                 295                 300                 





Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu Ala Arg 

305                 310                 315                 320 





Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro Pro Ala 

                325                 330                 335     





Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln Ala Val 

            340                 345                 350         





Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys Leu Pro 

        355                 360                 365             





Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg Lys Glu 

    370                 375                 380                 





Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser 

385                 390                 395                 400 





Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser Ala Leu 

                405                 410                 415     





Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu Glu Leu 

            420                 425                 430         





Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr Glu Thr 

        435                 440                 445             





Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His Pro Val 

    450                 455                 460                 





Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln Met Phe 

465                 470                 475                 480 





Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe Tyr Gln 

                485                 490                 495     





Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr Glu Ala 

            500                 505                 510         





Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro Glu Asn 

        515                 520                 525             





Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 

    530                 535                 540                 





Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 

545                 550                 555                 560 





Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly Gly Gly 

                565                 570                 575     





Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys Ser Gln 

            580                 585                 590         





Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro Ser Ala 

        595                 600                 605             





Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser Asn Phe 

    610                 615                 620                 





Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp Gly Lys 

625                 630                 635                 640 





Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser Asn Glu 

                645                 650                 655     





Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg Val Ser 

            660                 665                 670         





Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg Lys Arg 

        675                 680                 685             





Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys Glu Glu 

    690                 695                 700                 





Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser Ala Thr 

705                 710                 715                 720 





Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro 

                725                 730                 735     





Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu 

            740                 745                 750         





Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro 

        755                 760                 765             





Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr 

    770                 775                 780                 





Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg Pro Phe 

785                 790                 795                 800 





Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu Gly Leu 

                805                 810                 815     





Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro Ala Ser 

            820                 825                 830         





Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His Pro Leu 

        835                 840                 845             





Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro Gly Glu 

    850                 855                 860                 





Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser Gly Phe 

865                 870                 875                 880 





Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Val Ser Glu 

                885                 890                 895     





Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro Gly Glu Glu 

            900                 905                 910         





Pro Pro Ala 

        915 





<210>  166

<211>  914

<212>  PRT

<213>  Homo sapiens



<400>  166



Met Leu Ser Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met Gly Ala 

1               5                   10                  15      





Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe Gly Glu 

            20                  25                  30          





Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu Glu Leu 

        35                  40                  45              





Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly Glu Pro 

    50                  55                  60                  





Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro Pro Pro 

65                  70                  75                  80  





Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser Pro Gly 

                85                  90                  95      





Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly Pro Gly 

            100                 105                 110         





Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys Pro Ser 

        115                 120                 125             





Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala Ala Leu 

    130                 135                 140                 





Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp Tyr Pro 

145                 150                 155                 160 





Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln Gly Gly 

                165                 170                 175     





Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser Ser Trp 

            180                 185                 190         





Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala Ala Cys 

        195                 200                 205             





Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe Gly Leu 

    210                 215                 220                 





Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp Thr Pro 

225                 230                 235                 240 





Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg Gly Pro 

                245                 250                 255     





Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro Ala Ser 

            260                 265                 270         





Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser Ser Gly 

        275                 280                 285             





Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser Leu Gly 

    290                 295                 300                 





Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu Ala Arg 

305                 310                 315                 320 





Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro Pro Ala 

                325                 330                 335     





Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln Ala Val 

            340                 345                 350         





Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys Leu Pro 

        355                 360                 365             





Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg Lys Glu 

    370                 375                 380                 





Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser 

385                 390                 395                 400 





Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser Ala Leu 

                405                 410                 415     





Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu Glu Leu 

            420                 425                 430         





Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr Glu Thr 

        435                 440                 445             





Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His Pro Val 

    450                 455                 460                 





Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln Met Phe 

465                 470                 475                 480 





Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe Tyr Gln 

                485                 490                 495     





Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr Glu Ala 

            500                 505                 510         





Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro Glu Asn 

        515                 520                 525             





Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 

    530                 535                 540                 





Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 

545                 550                 555                 560 





Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly Gly Gly 

                565                 570                 575     





Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys Ser Gln 

            580                 585                 590         





Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro Ser Ala 

        595                 600                 605             





Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser Asn Phe 

    610                 615                 620                 





Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp Gly Lys 

625                 630                 635                 640 





Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser Asn Glu 

                645                 650                 655     





Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg Val Ser 

            660                 665                 670         





Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg Lys Arg 

        675                 680                 685             





Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys Glu Glu 

    690                 695                 700                 





Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser Ala Thr 

705                 710                 715                 720 





Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro 

                725                 730                 735     





Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu 

            740                 745                 750         





Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro 

        755                 760                 765             





Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr 

    770                 775                 780                 





Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg Pro Phe 

785                 790                 795                 800 





Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu Gly Leu 

                805                 810                 815     





Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro Ala Ser 

            820                 825                 830         





Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His Pro Leu 

        835                 840                 845             





Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro Gly Glu 

    850                 855                 860                 





Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser Gly Phe 

865                 870                 875                 880 





Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Gly Gly Cys 

                885                 890                 895     





Gly Thr Gly Gly Cys Glu Cys Glu Cys Val Gln Glu Ile Ala Leu His 

            900                 905                 910         





Val Cys 

        





<210>  167

<211>  901

<212>  PRT

<213>  Homo sapiens



<400>  167



Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

1               5                   10                  15      





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

            20                  25                  30          





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

        35                  40                  45              





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

    50                  55                  60                  





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

65                  70                  75                  80  





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

                85                  90                  95      





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

            100                 105                 110         





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

        115                 120                 125             





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

    130                 135                 140                 





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

145                 150                 155                 160 





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

                165                 170                 175     





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

            180                 185                 190         





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

        195                 200                 205             





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

    210                 215                 220                 





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

225                 230                 235                 240 





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

                245                 250                 255     





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

            260                 265                 270         





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

        275                 280                 285             





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

    290                 295                 300                 





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

305                 310                 315                 320 





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

                325                 330                 335     





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

            340                 345                 350         





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

        355                 360                 365             





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

    370                 375                 380                 





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

385                 390                 395                 400 





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

                405                 410                 415     





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

            420                 425                 430         





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

        435                 440                 445             





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

    450                 455                 460                 





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

465                 470                 475                 480 





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

                485                 490                 495     





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

            500                 505                 510         





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

        515                 520                 525             





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

    530                 535                 540                 





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

545                 550                 555                 560 





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

                565                 570                 575     





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

            580                 585                 590         





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

        595                 600                 605             





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

    610                 615                 620                 





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

625                 630                 635                 640 





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

                645                 650                 655     





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

            660                 665                 670         





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

        675                 680                 685             





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

    690                 695                 700                 





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

705                 710                 715                 720 





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

                725                 730                 735     





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

            740                 745                 750         





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

        755                 760                 765             





Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro 

    770                 775                 780                 





Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser 

785                 790                 795                 800 





Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu 

                805                 810                 815     





Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val 

            820                 825                 830         





His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly 

        835                 840                 845             





Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser 

    850                 855                 860                 





Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu 

865                 870                 875                 880 





Gly Gly Cys Gly Thr Gly Gly Cys Glu Cys Glu Cys Val Gln Glu Ile 

                885                 890                 895     





Ala Leu His Val Cys 

            900     





<210>  168

<211>  890

<212>  PRT

<213>  Homo sapiens



<400>  168



Met Pro Ala Ser Ile Ser Ser Ile Phe Pro Gly Pro Thr Leu Leu Leu 

1               5                   10                  15      





Ser Cys Gly Ser Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys 

            20                  25                  30          





Arg Leu Ala Leu Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly 

        35                  40                  45              





Ile Pro Arg Pro Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro 

    50                  55                  60                  





Arg Pro Ala Pro Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser 

65                  70                  75                  80  





Val Arg Leu Gly Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly 

                85                  90                  95      





Arg Val Leu Glu Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr 

            100                 105                 110         





Pro Glu Pro Pro Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp 

        115                 120                 125             





Gly Ser Pro Arg Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg 

    130                 135                 140                 





Glu Ala Gly Gly Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly 

145                 150                 155                 160 





Ser Ser Ser Leu Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu 

                165                 170                 175     





Ala Ala Leu Tyr Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu 

            180                 185                 190         





Ala Ala Ser Arg Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala 

        195                 200                 205             





Ser Pro Arg Pro Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro 

    210                 215                 220                 





Ser Pro Gly Gly Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala 

225                 230                 235                 240 





Pro Gly Pro Thr Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys 

                245                 250                 255     





Arg Arg Tyr Ser Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu 

            260                 265                 270         





Ser Arg Arg Gly Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro 

        275                 280                 285             





Pro Pro Leu Pro Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp 

    290                 295                 300                 





Tyr Val Gly Ala Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg 

305                 310                 315                 320 





Thr Ser Ser Glu Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala 

                325                 330                 335     





Ser Cys Asn Gly Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro 

            340                 345                 350         





Pro Gly Gly Ser Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val 

        355                 360                 365             





Pro Ser Pro Leu Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro 

    370                 375                 380                 





Ile Phe Arg Thr Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser 

385                 390                 395                 400 





Gln Tyr Glu Gln Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His 

                405                 410                 415     





His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala 

            420                 425                 430         





Ala Pro Gly Gly His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys 

        435                 440                 445             





Pro Leu Thr Leu Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu 

    450                 455                 460                 





Arg Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val 

465                 470                 475                 480 





Ala Thr Ala Ser Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu 

                485                 490                 495     





Met Thr Leu Leu Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala 

            500                 505                 510         





Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu 

        515                 520                 525             





Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 

    530                 535                 540                 





His Val Pro Gln Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser 

545                 550                 555                 560 





Val Pro Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val 

                565                 570                 575     





Glu Ala Tyr Ser Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu 

            580                 585                 590         





Val Leu Thr Gly Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile 

        595                 600                 605             





Glu Arg Gly Pro Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val 

    610                 615                 620                 





Asn Arg Leu Gln Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu 

625                 630                 635                 640 





Tyr Ser Asn Lys Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val 

                645                 650                 655     





Ser Asn Gly Arg Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu 

            660                 665                 670         





Pro Val Ile Cys Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly 

        675                 680                 685             





Phe Pro Ser Ala Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser 

    690                 695                 700                 





Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys 

705                 710                 715                 720 





Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu 

                725                 730                 735     





Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met 

            740                 745                 750         





Phe Pro Glu Thr Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val 

        755                 760                 765             





Ser Phe Leu Pro Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly 

    770                 775                 780                 





Ser Ser Phe Ser Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg 

785                 790                 795                 800 





Pro Pro Pro Leu Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser 

                805                 810                 815     





Gln Ser Asp Val His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly 

            820                 825                 830         





Pro Gly Tyr Gly Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg 

        835                 840                 845             





Gly Gly Tyr Ser Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile 

    850                 855                 860                 





Thr Leu Glu Glu Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe 

865                 870                 875                 880 





Pro Ala Pro Pro Gly Glu Glu Pro Pro Ala 

                885                 890 





<210>  169

<211>  889

<212>  PRT

<213>  Homo sapiens



<400>  169



Met Pro Ala Ser Ile Ser Ser Ile Phe Pro Gly Pro Thr Leu Leu Leu 

1               5                   10                  15      





Ser Cys Gly Ser Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys 

            20                  25                  30          





Arg Leu Ala Leu Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly 

        35                  40                  45              





Ile Pro Arg Pro Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro 

    50                  55                  60                  





Arg Pro Ala Pro Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser 

65                  70                  75                  80  





Val Arg Leu Gly Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly 

                85                  90                  95      





Arg Val Leu Glu Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr 

            100                 105                 110         





Pro Glu Pro Pro Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp 

        115                 120                 125             





Gly Ser Pro Arg Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg 

    130                 135                 140                 





Glu Ala Gly Gly Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly 

145                 150                 155                 160 





Ser Ser Ser Leu Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu 

                165                 170                 175     





Ala Ala Leu Tyr Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu 

            180                 185                 190         





Ala Ala Ser Arg Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala 

        195                 200                 205             





Ser Pro Arg Pro Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro 

    210                 215                 220                 





Ser Pro Gly Gly Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala 

225                 230                 235                 240 





Pro Gly Pro Thr Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys 

                245                 250                 255     





Arg Arg Tyr Ser Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu 

            260                 265                 270         





Ser Arg Arg Gly Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro 

        275                 280                 285             





Pro Pro Leu Pro Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp 

    290                 295                 300                 





Tyr Val Gly Ala Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg 

305                 310                 315                 320 





Thr Ser Ser Glu Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala 

                325                 330                 335     





Ser Cys Asn Gly Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro 

            340                 345                 350         





Pro Gly Gly Ser Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val 

        355                 360                 365             





Pro Ser Pro Leu Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro 

    370                 375                 380                 





Ile Phe Arg Thr Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser 

385                 390                 395                 400 





Gln Tyr Glu Gln Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His 

                405                 410                 415     





His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala 

            420                 425                 430         





Ala Pro Gly Gly His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys 

        435                 440                 445             





Pro Leu Thr Leu Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu 

    450                 455                 460                 





Arg Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val 

465                 470                 475                 480 





Ala Thr Ala Ser Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu 

                485                 490                 495     





Met Thr Leu Leu Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala 

            500                 505                 510         





Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu 

        515                 520                 525             





Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 

    530                 535                 540                 





His Val Pro Gln Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser 

545                 550                 555                 560 





Val Pro Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val 

                565                 570                 575     





Glu Ala Tyr Ser Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu 

            580                 585                 590         





Val Leu Thr Gly Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile 

        595                 600                 605             





Glu Arg Gly Pro Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val 

    610                 615                 620                 





Asn Arg Leu Gln Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu 

625                 630                 635                 640 





Tyr Ser Asn Lys Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val 

                645                 650                 655     





Ser Asn Gly Arg Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu 

            660                 665                 670         





Pro Val Ile Cys Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly 

        675                 680                 685             





Phe Pro Ser Ala Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser 

    690                 695                 700                 





Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys 

705                 710                 715                 720 





Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu 

                725                 730                 735     





Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met 

            740                 745                 750         





Phe Pro Glu Thr Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val 

        755                 760                 765             





Ser Phe Leu Pro Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly 

    770                 775                 780                 





Ser Ser Phe Ser Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg 

785                 790                 795                 800 





Pro Pro Pro Leu Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser 

                805                 810                 815     





Gln Ser Asp Val His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly 

            820                 825                 830         





Pro Gly Tyr Gly Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg 

        835                 840                 845             





Gly Gly Tyr Ser Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile 

    850                 855                 860                 





Thr Leu Glu Glu Gly Gly Cys Gly Thr Gly Gly Cys Glu Cys Glu Cys 

865                 870                 875                 880 





Val Gln Glu Ile Ala Leu His Val Cys 

                885                 





<210>  170

<211>  857

<212>  PRT

<213>  Homo sapiens



<400>  170



Met Ile Thr Thr Leu Pro Ser Leu Leu Pro Ala Ser Leu Ala Ser Ile 

1               5                   10                  15      





Ser His Arg Val Thr Asn Leu Pro Ser Asn Ser Leu Ser His Asn Pro 

            20                  25                  30          





Gly Leu Ser Lys Pro Asp Phe Pro Gly Asn Ser Ser Pro Gly Leu Pro 

        35                  40                  45              





Ser Ser Ser Ser Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met 

    50                  55                  60                  





Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe 

65                  70                  75                  80  





Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu 

                85                  90                  95      





Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly 

            100                 105                 110         





Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro 

        115                 120                 125             





Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser 

    130                 135                 140                 





Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly 

145                 150                 155                 160 





Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys 

                165                 170                 175     





Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala 

            180                 185                 190         





Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp 

        195                 200                 205             





Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln 

    210                 215                 220                 





Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser 

225                 230                 235                 240 





Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala 

                245                 250                 255     





Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe 

            260                 265                 270         





Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp 

        275                 280                 285             





Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg 

    290                 295                 300                 





Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro 

305                 310                 315                 320 





Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser 

                325                 330                 335     





Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser 

            340                 345                 350         





Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu 

        355                 360                 365             





Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro 

    370                 375                 380                 





Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln 

385                 390                 395                 400 





Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys 

                405                 410                 415     





Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg 

            420                 425                 430         





Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala 

        435                 440                 445             





Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser 

    450                 455                 460                 





Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu 

465                 470                 475                 480 





Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr 

                485                 490                 495     





Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His 

            500                 505                 510         





Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln 

        515                 520                 525             





Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

    530                 535                 540                 





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

545                 550                 555                 560 





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

                565                 570                 575     





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

            580                 585                 590         





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

        595                 600                 605             





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

    610                 615                 620                 





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

625                 630                 635                 640 





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

                645                 650                 655     





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

            660                 665                 670         





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

        675                 680                 685             





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

    690                 695                 700                 





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

705                 710                 715                 720 





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

                725                 730                 735     





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

            740                 745                 750         





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

        755                 760                 765             





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

    770                 775                 780                 





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

785                 790                 795                 800 





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

                805                 810                 815     





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

            820                 825                 830         





Gly Thr Thr Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro 

        835                 840                 845             





Ala Pro Pro Gly Glu Glu Pro Pro Ala 

    850                 855         





<210>  171

<211>  832

<212>  PRT

<213>  Homo sapiens



<400>  171



Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser Pro Gly Thr Trp Glu 

1               5                   10                  15      





Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly Pro Gly Gly Gly Ala 

            20                  25                  30          





Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys Pro Ser Ile Arg Ile 

        35                  40                  45              





Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala Ala Leu Glu Asp Asn 

    50                  55                  60                  





Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp Tyr Pro Pro Pro Glu 

65                  70                  75                  80  





Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln Gly Gly Gly Ala Phe 

                85                  90                  95      





Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser Ser Trp Ser Phe Phe 

            100                 105                 110         





Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala Ala Cys Asp Glu Val 

        115                 120                 125             





Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe Gly Leu Gly Ser Pro 

    130                 135                 140                 





Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp Thr Pro Glu Asp Pro 

145                 150                 155                 160 





Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg Gly Pro Glu Asp Ser 

                165                 170                 175     





Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro Ala Ser Pro Arg Pro 

            180                 185                 190         





Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser Ser Gly Thr Pro Ser 

        195                 200                 205             





Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser Leu Gly Glu Glu Gly 

    210                 215                 220                 





Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu Ala Arg Asp Pro Gly 

225                 230                 235                 240 





Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro Pro Ala Glu Ser Ile 

                245                 250                 255     





Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln Ala Val Ala Leu Pro 

            260                 265                 270         





Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys Leu Pro Leu Gly Ala 

        275                 280                 285             





Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg Lys Glu Val Ala Gly 

    290                 295                 300                 





Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser Lys Ala Arg 

305                 310                 315                 320 





Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser Ala Leu Pro Pro Leu 

                325                 330                 335     





Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu Glu Leu Arg Ile Glu 

            340                 345                 350         





Val Gln Pro Arg Ala His His Arg Ala His Tyr Glu Thr Glu Gly Ser 

        355                 360                 365             





Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His Pro Val Val Lys Leu 

    370                 375                 380                 





Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln Met Phe Ile Gly Thr 

385                 390                 395                 400 





Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe Tyr Gln Val His Arg 

                405                 410                 415     





Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr Glu Ala Val Val Ser 

            420                 425                 430         





Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro Glu Asn Asn Met Ala 

        435                 440                 445             





Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile 

    450                 455                 460                 





Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val 

465                 470                 475                 480 





Arg Leu Val Phe Arg Val His Val Pro Gln Gly Gly Gly Lys Val Val 

                485                 490                 495     





Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys Ser Gln Arg Ser Ala 

            500                 505                 510         





Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro Ser Ala Cys Ser Val 

        515                 520                 525             





Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser Asn Phe Leu Pro Asp 

    530                 535                 540                 





Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp Gly Lys Leu Gln Trp 

545                 550                 555                 560 





Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser Asn Glu Val Thr Leu 

                565                 570                 575     





Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg Val Ser Arg Pro Val 

            580                 585                 590         





Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg Lys Arg Ser Pro Thr 

        595                 600                 605             





Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys Glu Glu Pro Leu Pro 

    610                 615                 620                 





Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser Ala Thr Pro Phe Gly 

625                 630                 635                 640 





Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro 

                645                 650                 655     





His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly 

            660                 665                 670         





Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr 

        675                 680                 685             





Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr Thr Gly Cys 

    690                 695                 700                 





Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg Pro Phe Pro Ser Asp 

705                 710                 715                 720 





Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu Gly Leu Pro Phe Ser 

                725                 730                 735     





Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro Ala Ser Pro Pro Leu 

            740                 745                 750         





Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His Pro Leu Pro Ala Glu 

        755                 760                 765             





Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro Gly Glu Gly Ala Pro 

    770                 775                 780                 





Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser Gly Phe Arg Asp Ser 

785                 790                 795                 800 





Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Val Ser Glu Ile Ile Gly 

                805                 810                 815     





Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro Gly Glu Glu Pro Pro Ala 

            820                 825                 830         





<210>  172

<211>  831

<212>  PRT

<213>  Homo sapiens



<400>  172



Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser Pro Gly Thr Trp Glu 

1               5                   10                  15      





Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly Pro Gly Gly Gly Ala 

            20                  25                  30          





Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys Pro Ser Ile Arg Ile 

        35                  40                  45              





Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala Ala Leu Glu Asp Asn 

    50                  55                  60                  





Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp Tyr Pro Pro Pro Glu 

65                  70                  75                  80  





Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln Gly Gly Gly Ala Phe 

                85                  90                  95      





Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser Ser Trp Ser Phe Phe 

            100                 105                 110         





Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala Ala Cys Asp Glu Val 

        115                 120                 125             





Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe Gly Leu Gly Ser Pro 

    130                 135                 140                 





Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp Thr Pro Glu Asp Pro 

145                 150                 155                 160 





Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg Gly Pro Glu Asp Ser 

                165                 170                 175     





Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro Ala Ser Pro Arg Pro 

            180                 185                 190         





Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser Ser Gly Thr Pro Ser 

        195                 200                 205             





Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser Leu Gly Glu Glu Gly 

    210                 215                 220                 





Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu Ala Arg Asp Pro Gly 

225                 230                 235                 240 





Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro Pro Ala Glu Ser Ile 

                245                 250                 255     





Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln Ala Val Ala Leu Pro 

            260                 265                 270         





Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys Leu Pro Leu Gly Ala 

        275                 280                 285             





Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg Lys Glu Val Ala Gly 

    290                 295                 300                 





Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser Lys Ala Arg 

305                 310                 315                 320 





Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser Ala Leu Pro Pro Leu 

                325                 330                 335     





Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu Glu Leu Arg Ile Glu 

            340                 345                 350         





Val Gln Pro Arg Ala His His Arg Ala His Tyr Glu Thr Glu Gly Ser 

        355                 360                 365             





Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His Pro Val Val Lys Leu 

    370                 375                 380                 





Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln Met Phe Ile Gly Thr 

385                 390                 395                 400 





Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe Tyr Gln Val His Arg 

                405                 410                 415     





Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr Glu Ala Val Val Ser 

            420                 425                 430         





Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro Glu Asn Asn Met Ala 

        435                 440                 445             





Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile 

    450                 455                 460                 





Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val 

465                 470                 475                 480 





Arg Leu Val Phe Arg Val His Val Pro Gln Gly Gly Gly Lys Val Val 

                485                 490                 495     





Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys Ser Gln Arg Ser Ala 

            500                 505                 510         





Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro Ser Ala Cys Ser Val 

        515                 520                 525             





Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser Asn Phe Leu Pro Asp 

    530                 535                 540                 





Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp Gly Lys Leu Gln Trp 

545                 550                 555                 560 





Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser Asn Glu Val Thr Leu 

                565                 570                 575     





Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg Val Ser Arg Pro Val 

            580                 585                 590         





Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg Lys Arg Ser Pro Thr 

        595                 600                 605             





Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys Glu Glu Pro Leu Pro 

    610                 615                 620                 





Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser Ala Thr Pro Phe Gly 

625                 630                 635                 640 





Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro 

                645                 650                 655     





His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly 

            660                 665                 670         





Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr 

        675                 680                 685             





Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr Thr Gly Cys 

    690                 695                 700                 





Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg Pro Phe Pro Ser Asp 

705                 710                 715                 720 





Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu Gly Leu Pro Phe Ser 

                725                 730                 735     





Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro Ala Ser Pro Pro Leu 

            740                 745                 750         





Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His Pro Leu Pro Ala Glu 

        755                 760                 765             





Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro Gly Glu Gly Ala Pro 

    770                 775                 780                 





Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser Gly Phe Arg Asp Ser 

785                 790                 795                 800 





Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Gly Gly Cys Gly Thr Gly 

                805                 810                 815     





Gly Cys Glu Cys Glu Cys Val Gln Glu Ile Ala Leu His Val Cys 

            820                 825                 830     





<210>  173

<211>  826

<212>  PRT

<213>  Homo sapiens



<400>  173



Met Ala Asp Gly Gly Ala Asp Ser Ala Ala Gln Arg Leu Pro Glu Gly 

1               5                   10                  15      





Pro Gly Arg Val Ala Pro Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser 

            20                  25                  30          





Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

        35                  40                  45              





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

    50                  55                  60                  





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

65                  70                  75                  80  





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

                85                  90                  95      





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

            100                 105                 110         





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

        115                 120                 125             





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

    130                 135                 140                 





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

145                 150                 155                 160 





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

                165                 170                 175     





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

            180                 185                 190         





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

        195                 200                 205             





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

    210                 215                 220                 





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

225                 230                 235                 240 





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

                245                 250                 255     





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

            260                 265                 270         





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

        275                 280                 285             





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

    290                 295                 300                 





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

305                 310                 315                 320 





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

                325                 330                 335     





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

            340                 345                 350         





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

        355                 360                 365             





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

    370                 375                 380                 





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

385                 390                 395                 400 





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

                405                 410                 415     





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

            420                 425                 430         





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

        435                 440                 445             





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

    450                 455                 460                 





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

465                 470                 475                 480 





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

                485                 490                 495     





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

            500                 505                 510         





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

        515                 520                 525             





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

    530                 535                 540                 





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

545                 550                 555                 560 





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

                565                 570                 575     





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

            580                 585                 590         





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

        595                 600                 605             





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

    610                 615                 620                 





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

625                 630                 635                 640 





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

                645                 650                 655     





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

            660                 665                 670         





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

        675                 680                 685             





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

    690                 695                 700                 





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

705                 710                 715                 720 





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

                725                 730                 735     





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

            740                 745                 750         





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

        755                 760                 765             





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

    770                 775                 780                 





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

785                 790                 795                 800 





Arg Gly Thr Thr Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe 

                805                 810                 815     





Pro Ala Pro Pro Gly Glu Glu Pro Pro Ala 

            820                 825     





<210>  174

<211>  807

<212>  PRT

<213>  Homo sapiens



<400>  174



Met Leu Ser Gly Arg Asp Leu Gly Ala Pro Ala Gly Ser Met Gly Ala 

1               5                   10                  15      





Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val Phe Gly Glu 

            20                  25                  30          





Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly Glu Glu Leu 

        35                  40                  45              





Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu Gly Glu Pro 

    50                  55                  60                  





Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro Pro Pro Pro 

65                  70                  75                  80  





Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser Pro Gly 

                85                  90                  95      





Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly Pro Gly 

            100                 105                 110         





Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys Pro Ser 

        115                 120                 125             





Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala Ala Leu 

    130                 135                 140                 





Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp Tyr Pro 

145                 150                 155                 160 





Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln Gly Gly 

                165                 170                 175     





Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser Ser Trp 

            180                 185                 190         





Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala Ala Cys 

        195                 200                 205             





Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe Gly Leu 

    210                 215                 220                 





Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp Thr Pro 

225                 230                 235                 240 





Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg Gly Pro 

                245                 250                 255     





Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro Ala Ser 

            260                 265                 270         





Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser Ser Gly 

        275                 280                 285             





Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser Leu Gly 

    290                 295                 300                 





Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu Ala Arg 

305                 310                 315                 320 





Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro Pro Ala 

                325                 330                 335     





Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln Ala Val 

            340                 345                 350         





Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys Leu Pro 

        355                 360                 365             





Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg Lys Glu 

    370                 375                 380                 





Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser 

385                 390                 395                 400 





Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser Ala Leu 

                405                 410                 415     





Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu Glu Leu 

            420                 425                 430         





Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His Tyr Glu Thr 

        435                 440                 445             





Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His Pro Val 

    450                 455                 460                 





Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln Met Phe 

465                 470                 475                 480 





Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe Tyr Gln 

                485                 490                 495     





Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr Glu Ala 

            500                 505                 510         





Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro Glu Asn 

        515                 520                 525             





Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 

    530                 535                 540                 





Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 

545                 550                 555                 560 





Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly Gly Gly 

                565                 570                 575     





Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys Ser Gln 

            580                 585                 590         





Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro Ser Ala 

        595                 600                 605             





Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser Asn Phe 

    610                 615                 620                 





Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp Gly Lys 

625                 630                 635                 640 





Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser Asn Glu 

                645                 650                 655     





Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg Val Ser 

            660                 665                 670         





Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg Lys Arg 

        675                 680                 685             





Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys Glu Glu 

    690                 695                 700                 





Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser Ala Thr 

705                 710                 715                 720 





Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro 

                725                 730                 735     





Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu 

            740                 745                 750         





Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro 

        755                 760                 765             





Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr 

    770                 775                 780                 





Thr Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro 

785                 790                 795                 800 





Pro Gly Glu Glu Pro Pro Ala 

                805         





<210>  175

<211>  794

<212>  PRT

<213>  Homo sapiens



<400>  175



Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 

1               5                   10                  15      





Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 

            20                  25                  30          





Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 

        35                  40                  45              





Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 

    50                  55                  60                  





Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 

65                  70                  75                  80  





Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 

                85                  90                  95      





Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 

            100                 105                 110         





Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 

        115                 120                 125             





Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 

    130                 135                 140                 





Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 

145                 150                 155                 160 





Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 

                165                 170                 175     





Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 

            180                 185                 190         





Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 

        195                 200                 205             





Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 

    210                 215                 220                 





Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 

225                 230                 235                 240 





Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 

                245                 250                 255     





Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 

            260                 265                 270         





Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 

        275                 280                 285             





Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 

    290                 295                 300                 





Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 

305                 310                 315                 320 





Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 

                325                 330                 335     





Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 

            340                 345                 350         





Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 

        355                 360                 365             





Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 

    370                 375                 380                 





Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 

385                 390                 395                 400 





Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 

                405                 410                 415     





Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 

            420                 425                 430         





Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 

        435                 440                 445             





His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 

    450                 455                 460                 





Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 

465                 470                 475                 480 





Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 

                485                 490                 495     





Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 

            500                 505                 510         





Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 

        515                 520                 525             





Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 

    530                 535                 540                 





Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 

545                 550                 555                 560 





Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 

                565                 570                 575     





Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 

            580                 585                 590         





Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 

        595                 600                 605             





Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 

    610                 615                 620                 





Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 

625                 630                 635                 640 





Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 

                645                 650                 655     





Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 

            660                 665                 670         





Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 

        675                 680                 685             





Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 

    690                 695                 700                 





Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 

705                 710                 715                 720 





Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 

                725                 730                 735     





Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 

            740                 745                 750         





Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 

        755                 760                 765             





Arg Gly Thr Thr Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe 

    770                 775                 780                 





Pro Ala Pro Pro Gly Glu Glu Pro Pro Ala 

785                 790                 





<210>  176

<211>  782

<212>  PRT

<213>  Homo sapiens



<400>  176



Met Pro Ala Ser Ile Ser Ser Ile Phe Pro Gly Pro Thr Leu Leu Leu 

1               5                   10                  15      





Ser Cys Gly Ser Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys 

            20                  25                  30          





Arg Leu Ala Leu Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly 

        35                  40                  45              





Ile Pro Arg Pro Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro 

    50                  55                  60                  





Arg Pro Ala Pro Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser 

65                  70                  75                  80  





Val Arg Leu Gly Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly 

                85                  90                  95      





Arg Val Leu Glu Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr 

            100                 105                 110         





Pro Glu Pro Pro Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp 

        115                 120                 125             





Gly Ser Pro Arg Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg 

    130                 135                 140                 





Glu Ala Gly Gly Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly 

145                 150                 155                 160 





Ser Ser Ser Leu Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu 

                165                 170                 175     





Ala Ala Leu Tyr Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu 

            180                 185                 190         





Ala Ala Ser Arg Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala 

        195                 200                 205             





Ser Pro Arg Pro Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro 

    210                 215                 220                 





Ser Pro Gly Gly Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala 

225                 230                 235                 240 





Pro Gly Pro Thr Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys 

                245                 250                 255     





Arg Arg Tyr Ser Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu 

            260                 265                 270         





Ser Arg Arg Gly Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro 

        275                 280                 285             





Pro Pro Leu Pro Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp 

    290                 295                 300                 





Tyr Val Gly Ala Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg 

305                 310                 315                 320 





Thr Ser Ser Glu Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala 

                325                 330                 335     





Ser Cys Asn Gly Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro 

            340                 345                 350         





Pro Gly Gly Ser Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val 

        355                 360                 365             





Pro Ser Pro Leu Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro 

    370                 375                 380                 





Ile Phe Arg Thr Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser 

385                 390                 395                 400 





Gln Tyr Glu Gln Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His 

                405                 410                 415     





His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala 

            420                 425                 430         





Ala Pro Gly Gly His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys 

        435                 440                 445             





Pro Leu Thr Leu Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu 

    450                 455                 460                 





Arg Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val 

465                 470                 475                 480 





Ala Thr Ala Ser Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu 

                485                 490                 495     





Met Thr Leu Leu Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala 

            500                 505                 510         





Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu 

        515                 520                 525             





Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 

    530                 535                 540                 





His Val Pro Gln Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser 

545                 550                 555                 560 





Val Pro Ile Glu Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val 

                565                 570                 575     





Glu Ala Tyr Ser Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu 

            580                 585                 590         





Val Leu Thr Gly Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile 

        595                 600                 605             





Glu Arg Gly Pro Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val 

    610                 615                 620                 





Asn Arg Leu Gln Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu 

625                 630                 635                 640 





Tyr Ser Asn Lys Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val 

                645                 650                 655     





Ser Asn Gly Arg Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu 

            660                 665                 670         





Pro Val Ile Cys Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly 

        675                 680                 685             





Phe Pro Ser Ala Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser 

    690                 695                 700                 





Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys 

705                 710                 715                 720 





Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu 

                725                 730                 735     





Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met 

            740                 745                 750         





Phe Pro Glu Thr Arg Gly Thr Thr Val Ser Glu Ile Ile Gly Arg Asp 

        755                 760                 765             





Leu Ser Gly Phe Pro Ala Pro Pro Gly Glu Glu Pro Pro Ala 

    770                 775                 780         





<210>  177

<211>  724

<212>  PRT

<213>  Homo sapiens



<400>  177



Met His Ser Pro Pro Pro Arg Pro Ala Pro Ser Pro Gly Thr Trp Glu 

1               5                   10                  15      





Ser Gln Pro Ala Arg Ser Val Arg Leu Gly Gly Pro Gly Gly Gly Ala 

            20                  25                  30          





Gly Gly Ala Gly Gly Gly Arg Val Leu Glu Cys Pro Ser Ile Arg Ile 

        35                  40                  45              





Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro Ala Ala Leu Glu Asp Asn 

    50                  55                  60                  





Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg Asp Tyr Pro Pro Pro Glu 

65                  70                  75                  80  





Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly Gln Gly Gly Gly Ala Phe 

                85                  90                  95      





Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu Ser Ser Trp Ser Phe Phe 

            100                 105                 110         





Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr Ala Ala Cys Asp Glu Val 

        115                 120                 125             





Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg Phe Gly Leu Gly Ser Pro 

    130                 135                 140                 





Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro Trp Thr Pro Glu Asp Pro 

145                 150                 155                 160 





Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly Arg Gly Pro Glu Asp Ser 

                165                 170                 175     





Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr Pro Ala Ser Pro Arg Pro 

            180                 185                 190         





Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser Ser Ser Gly Thr Pro Ser 

        195                 200                 205             





Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly Ser Leu Gly Glu Glu Gly 

    210                 215                 220                 





Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro Leu Ala Arg Asp Pro Gly 

225                 230                 235                 240 





Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala Pro Pro Ala Glu Ser Ile 

                245                 250                 255     





Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu Gln Ala Val Ala Leu Pro 

            260                 265                 270         





Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly Lys Leu Pro Leu Gly Ala 

        275                 280                 285             





Glu Glu Ser Val Ala Pro Pro Gly Gly Ser Arg Lys Glu Val Ala Gly 

    290                 295                 300                 





Met Asp Tyr Leu Ala Val Pro Ser Pro Leu Ala Trp Ser Lys Ala Arg 

305                 310                 315                 320 





Ile Gly Gly His Ser Pro Ile Phe Arg Thr Ser Ala Leu Pro Pro Leu 

                325                 330                 335     





Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln Leu Glu Leu Arg Ile Glu 

            340                 345                 350         





Val Gln Pro Arg Ala His His Arg Ala His Tyr Glu Thr Glu Gly Ser 

        355                 360                 365             





Arg Gly Ala Val Lys Ala Ala Pro Gly Gly His Pro Val Val Lys Leu 

    370                 375                 380                 





Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu Gln Met Phe Ile Gly Thr 

385                 390                 395                 400 





Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe Tyr Gln Val His Arg 

                405                 410                 415     





Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr Glu Ala Val Val Ser 

            420                 425                 430         





Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro Glu Asn Asn Met Ala 

        435                 440                 445             





Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile 

    450                 455                 460                 





Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val 

465                 470                 475                 480 





Arg Leu Val Phe Arg Val His Val Pro Gln Gly Gly Gly Lys Val Val 

                485                 490                 495     





Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys Ser Gln Arg Ser Ala 

            500                 505                 510         





Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro Ser Ala Cys Ser Val 

        515                 520                 525             





Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser Asn Phe Leu Pro Asp 

    530                 535                 540                 





Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp Gly Lys Leu Gln Trp 

545                 550                 555                 560 





Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser Asn Glu Val Thr Leu 

                565                 570                 575     





Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg Val Ser Arg Pro Val 

            580                 585                 590         





Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg Lys Arg Ser Pro Thr 

        595                 600                 605             





Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys Glu Glu Pro Leu Pro 

    610                 615                 620                 





Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser Ala Thr Pro Phe Gly 

625                 630                 635                 640 





Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro 

                645                 650                 655     





His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly 

            660                 665                 670         





Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr 

        675                 680                 685             





Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr Thr Val Ser 

    690                 695                 700                 





Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro Gly Glu 

705                 710                 715                 720 





Glu Pro Pro Ala 

                





<210>  178

<211>  437

<212>  PRT

<213>  Homo sapiens



<400>  178



Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

1               5                   10                  15      





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

            20                  25                  30          





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

        35                  40                  45              





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

    50                  55                  60                  





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

65                  70                  75                  80  





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

                85                  90                  95      





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

            100                 105                 110         





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

        115                 120                 125             





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

    130                 135                 140                 





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

145                 150                 155                 160 





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

                165                 170                 175     





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

            180                 185                 190         





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

        195                 200                 205             





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

    210                 215                 220                 





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

225                 230                 235                 240 





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

                245                 250                 255     





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

            260                 265                 270         





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

        275                 280                 285             





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

    290                 295                 300                 





Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg 

305                 310                 315                 320 





Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu 

                325                 330                 335     





Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro 

            340                 345                 350         





Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His 

        355                 360                 365             





Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro 

    370                 375                 380                 





Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser 

385                 390                 395                 400 





Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Val 

                405                 410                 415     





Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro Gly 

            420                 425                 430         





Glu Glu Pro Pro Ala 

        435         





<210>  179

<211>  436

<212>  PRT

<213>  Homo sapiens



<400>  179



Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

1               5                   10                  15      





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

            20                  25                  30          





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

        35                  40                  45              





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

    50                  55                  60                  





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

65                  70                  75                  80  





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

                85                  90                  95      





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

            100                 105                 110         





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

        115                 120                 125             





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

    130                 135                 140                 





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

145                 150                 155                 160 





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

                165                 170                 175     





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

            180                 185                 190         





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

        195                 200                 205             





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

    210                 215                 220                 





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

225                 230                 235                 240 





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

                245                 250                 255     





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

            260                 265                 270         





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

        275                 280                 285             





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

    290                 295                 300                 





Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro Arg 

305                 310                 315                 320 





Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser Leu 

                325                 330                 335     





Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu Pro 

            340                 345                 350         





Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val His 

        355                 360                 365             





Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly Pro 

    370                 375                 380                 





Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser Ser 

385                 390                 395                 400 





Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu Gly 

                405                 410                 415     





Gly Cys Gly Thr Gly Gly Cys Glu Cys Glu Cys Val Gln Glu Ile Ala 

            420                 425                 430         





Leu His Val Cys 

        435     





<210>  180

<211>  329

<212>  PRT

<213>  Homo sapiens



<400>  180



Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala Phe 

1               5                   10                  15      





Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser Tyr 

            20                  25                  30          





Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu Pro 

        35                  40                  45              





Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys Leu 

    50                  55                  60                  





Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg 

65                  70                  75                  80  





Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Gly 

                85                  90                  95      





Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu Cys 

            100                 105                 110         





Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser Pro 

        115                 120                 125             





Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly Ser 

    130                 135                 140                 





Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro Asp 

145                 150                 155                 160 





Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln Ser 

                165                 170                 175     





Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys Arg 

            180                 185                 190         





Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg Arg 

        195                 200                 205             





Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys Lys 

    210                 215                 220                 





Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala Ser 

225                 230                 235                 240 





Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro Pro 

                245                 250                 255     





Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr Leu 

            260                 265                 270         





Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr Gly 

        275                 280                 285             





Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr Arg 

    290                 295                 300                 





Gly Thr Thr Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro 

305                 310                 315                 320 





Ala Pro Pro Gly Glu Glu Pro Pro Ala 

                325                 





<210>  181

<211>  190

<212>  PRT

<213>  Homo sapiens



<400>  181



Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro His Glu 

1               5                   10                  15      





Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly Tyr Gly 

            20                  25                  30          





Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr Arg Pro 

        35                  40                  45              





Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr Thr Gly Cys Ala Gln 

    50                  55                  60                  





Pro Pro Ala Val Ser Phe Leu Pro Arg Pro Phe Pro Ser Asp Pro Tyr 

65                  70                  75                  80  





Gly Gly Arg Gly Ser Ser Phe Ser Leu Gly Leu Pro Phe Ser Pro Pro 

                85                  90                  95      





Ala Pro Phe Arg Pro Pro Pro Leu Pro Ala Ser Pro Pro Leu Glu Gly 

            100                 105                 110         





Pro Phe Pro Ser Gln Ser Asp Val His Pro Leu Pro Ala Glu Gly Tyr 

        115                 120                 125             





Asn Lys Val Gly Pro Gly Tyr Gly Pro Gly Glu Gly Ala Pro Glu Gln 

    130                 135                 140                 





Glu Lys Ser Arg Gly Gly Tyr Ser Ser Gly Phe Arg Asp Ser Val Pro 

145                 150                 155                 160 





Ile Gln Gly Ile Thr Leu Glu Glu Val Ser Glu Ile Ile Gly Arg Asp 

                165                 170                 175     





Leu Ser Gly Phe Pro Ala Pro Pro Gly Glu Glu Pro Pro Ala 

            180                 185                 190 





<210>  182

<211>  189

<212>  PRT

<213>  Homo sapiens



<400>  182



Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro His Glu 

1               5                   10                  15      





Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly Tyr Gly 

            20                  25                  30          





Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr Arg Pro 

        35                  40                  45              





Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr Thr Gly Cys Ala Gln 

    50                  55                  60                  





Pro Pro Ala Val Ser Phe Leu Pro Arg Pro Phe Pro Ser Asp Pro Tyr 

65                  70                  75                  80  





Gly Gly Arg Gly Ser Ser Phe Ser Leu Gly Leu Pro Phe Ser Pro Pro 

                85                  90                  95      





Ala Pro Phe Arg Pro Pro Pro Leu Pro Ala Ser Pro Pro Leu Glu Gly 

            100                 105                 110         





Pro Phe Pro Ser Gln Ser Asp Val His Pro Leu Pro Ala Glu Gly Tyr 

        115                 120                 125             





Asn Lys Val Gly Pro Gly Tyr Gly Pro Gly Glu Gly Ala Pro Glu Gln 

    130                 135                 140                 





Glu Lys Ser Arg Gly Gly Tyr Ser Ser Gly Phe Arg Asp Ser Val Pro 

145                 150                 155                 160 





Ile Gln Gly Ile Thr Leu Glu Glu Gly Gly Cys Gly Thr Gly Gly Cys 

                165                 170                 175     





Glu Cys Glu Cys Val Gln Glu Ile Ala Leu His Val Cys 

            180                 185                 





<210>  183

<211>  82

<212>  PRT

<213>  Homo sapiens



<400>  183



Met Asp Phe Ser Pro Pro Arg Pro Pro Tyr Pro Ser Tyr Pro His Glu 

1               5                   10                  15      





Asp Pro Ala Cys Glu Thr Pro Tyr Leu Ser Glu Gly Phe Gly Tyr Gly 

            20                  25                  30          





Met Pro Pro Leu Tyr Pro Gln Thr Gly Pro Pro Pro Ser Tyr Arg Pro 

        35                  40                  45              





Gly Leu Arg Met Phe Pro Glu Thr Arg Gly Thr Thr Val Ser Glu Ile 

    50                  55                  60                  





Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro Gly Glu Glu Pro 

65                  70                  75                  80  





Pro Ala 

        





<210>  184

<211>  390

<212>  PRT

<213>  Homo sapiens



<400>  184



Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 

1               5                   10                  15      





Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 

            20                  25                  30          





Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 

        35                  40                  45              





Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 

    50                  55                  60                  





Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 

65                  70                  75                  80  





Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 

                85                  90                  95      





Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 

            100                 105                 110         





Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 

        115                 120                 125             





His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 

    130                 135                 140                 





Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 

145                 150                 155                 160 





Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 

                165                 170                 175     





Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 

            180                 185                 190         





Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 

        195                 200                 205             





Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 

    210                 215                 220                 





Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 

225                 230                 235                 240 





Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 

                245                 250                 255     





Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 

            260                 265                 270         





Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 

        275                 280                 285             





Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 

    290                 295                 300                 





Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 

305                 310                 315                 320 





Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 

                325                 330                 335     





Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 

            340                 345                 350         





Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 

        355                 360                 365             





Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 

    370                 375                 380                 





Arg Ser Cys Lys Cys Ser 

385                 390 





<210>  185

<211>  396

<212>  PRT

<213>  Homo sapiens



<400>  185



Met Pro Arg Val Lys Ala Ala Gln Ala Gly Arg Gln Ser Ser Ala Lys 

1               5                   10                  15      





Arg His Leu Ala Glu Gln Phe Ala Val Gly Glu Ile Ile Thr Asp Met 

            20                  25                  30          





Ala Lys Lys Glu Trp Lys Val Gly Leu Pro Ile Gly Gln Gly Gly Phe 

        35                  40                  45              





Gly Cys Ile Tyr Leu Ala Asp Met Asn Ser Ser Glu Ser Val Gly Ser 

    50                  55                  60                  





Asp Ala Pro Cys Val Val Lys Val Glu Pro Ser Asp Asn Gly Pro Leu 

65                  70                  75                  80  





Phe Thr Glu Leu Lys Phe Tyr Gln Arg Ala Ala Lys Pro Glu Gln Ile 

                85                  90                  95      





Gln Lys Trp Ile Arg Thr Arg Lys Leu Lys Tyr Leu Gly Val Pro Lys 

            100                 105                 110         





Tyr Trp Gly Ser Gly Leu His Asp Lys Asn Gly Lys Ser Tyr Arg Phe 

        115                 120                 125             





Met Ile Met Asp Arg Phe Gly Ser Asp Leu Gln Lys Ile Tyr Glu Ala 

    130                 135                 140                 





Asn Ala Lys Arg Phe Ser Arg Lys Thr Val Leu Gln Leu Ser Leu Arg 

145                 150                 155                 160 





Ile Leu Asp Ile Leu Glu Tyr Ile His Glu His Glu Tyr Val His Gly 

                165                 170                 175     





Asp Ile Lys Ala Ser Asn Leu Leu Leu Asn Tyr Lys Asn Pro Asp Gln 

            180                 185                 190         





Val Tyr Leu Val Asp Tyr Gly Leu Ala Tyr Arg Tyr Cys Pro Glu Gly 

        195                 200                 205             





Val His Lys Glu Tyr Lys Glu Asp Pro Lys Arg Cys His Asp Gly Thr 

    210                 215                 220                 





Ile Glu Phe Thr Ser Ile Asp Ala His Asn Gly Val Ala Pro Ser Arg 

225                 230                 235                 240 





Arg Gly Asp Leu Glu Ile Leu Gly Tyr Cys Met Ile Gln Trp Leu Thr 

                245                 250                 255     





Gly His Leu Pro Trp Glu Asp Asn Leu Lys Asp Pro Lys Tyr Val Arg 

            260                 265                 270         





Asp Ser Lys Ile Arg Tyr Arg Glu Asn Ile Ala Ser Leu Met Asp Lys 

        275                 280                 285             





Cys Phe Pro Glu Lys Asn Lys Pro Gly Glu Ile Ala Lys Tyr Met Glu 

    290                 295                 300                 





Thr Val Lys Leu Leu Asp Tyr Thr Glu Lys Pro Leu Tyr Glu Asn Leu 

305                 310                 315                 320 





Arg Asp Ile Leu Leu Gln Gly Leu Lys Ala Ile Gly Ser Lys Asp Asp 

                325                 330                 335     





Gly Lys Leu Asp Leu Ser Val Val Glu Asn Gly Gly Leu Lys Ala Lys 

            340                 345                 350         





Thr Ile Thr Lys Lys Arg Lys Lys Glu Ile Glu Glu Ser Lys Glu Pro 

        355                 360                 365             





Gly Val Glu Asp Thr Glu Trp Ser Asn Thr Gln Thr Glu Glu Ala Ile 

    370                 375                 380                 





Gln Thr Arg Ser Arg Thr Arg Lys Arg Val Gln Lys 

385                 390                 395     





<210>  186

<211>  212

<212>  PRT

<213>  Homo sapiens



<400>  186



Met Lys Pro Pro Ser Ser Ile Gln Thr Ser Glu Phe Asp Ser Ser Asp 

1               5                   10                  15      





Glu Glu Pro Ile Glu Asp Glu Gln Thr Pro Ile His Ile Ser Trp Leu 

            20                  25                  30          





Ser Leu Ser Arg Val Asn Cys Ser Gln Phe Leu Gly Leu Cys Ala Leu 

        35                  40                  45              





Pro Gly Cys Lys Phe Lys Asp Val Arg Arg Asn Val Gln Lys Asp Thr 

    50                  55                  60                  





Glu Glu Leu Lys Ser Cys Gly Ile Gln Asp Ile Phe Val Phe Cys Thr 

65                  70                  75                  80  





Arg Gly Glu Leu Ser Lys Tyr Arg Val Pro Asn Leu Leu Asp Leu Tyr 

                85                  90                  95      





Gln Gln Cys Gly Ile Ile Thr His His His Pro Ile Ala Asp Gly Gly 

            100                 105                 110         





Thr Pro Asp Ile Ala Ser Cys Cys Glu Ile Met Glu Glu Leu Thr Thr 

        115                 120                 125             





Cys Leu Lys Asn Tyr Arg Lys Thr Leu Ile His Cys Tyr Gly Gly Leu 

    130                 135                 140                 





Gly Arg Ser Cys Leu Val Ala Ala Cys Leu Leu Leu Tyr Leu Ser Asp 

145                 150                 155                 160 





Thr Ile Ser Pro Glu Gln Ala Ile Asp Ser Leu Arg Asp Leu Arg Gly 

                165                 170                 175     





Ser Gly Ala Ile Gln Thr Ile Lys Gln Tyr Asn Tyr Leu His Glu Phe 

            180                 185                 190         





Arg Asp Lys Leu Ala Ala His Leu Ser Ser Arg Asp Ser Gln Ser Arg 

        195                 200                 205             





Ser Val Ser Arg 

    210         





<210>  187

<211>  172

<212>  PRT

<213>  Homo sapiens



<400>  187



Met Lys Pro Pro Ser Ser Ile Gln Thr Ser Cys Lys Phe Lys Asp Val 

1               5                   10                  15      





Arg Arg Asn Val Gln Lys Asp Thr Glu Glu Leu Lys Ser Cys Gly Ile 

            20                  25                  30          





Gln Asp Ile Phe Val Phe Cys Thr Arg Gly Glu Leu Ser Lys Tyr Arg 

        35                  40                  45              





Val Pro Asn Leu Leu Asp Leu Tyr Gln Gln Cys Gly Ile Ile Thr His 

    50                  55                  60                  





His His Pro Ile Ala Asp Gly Gly Thr Pro Asp Ile Ala Ser Cys Cys 

65                  70                  75                  80  





Glu Ile Met Glu Glu Leu Thr Thr Cys Leu Lys Asn Tyr Arg Lys Thr 

                85                  90                  95      





Leu Ile His Cys Tyr Gly Gly Leu Gly Arg Ser Cys Leu Val Ala Ala 

            100                 105                 110         





Cys Leu Leu Leu Tyr Leu Ser Asp Thr Ile Ser Pro Glu Gln Ala Ile 

        115                 120                 125             





Asp Ser Leu Arg Asp Leu Arg Gly Ser Gly Ala Ile Gln Thr Ile Lys 

    130                 135                 140                 





Gln Tyr Asn Tyr Leu His Glu Phe Arg Asp Lys Leu Ala Ala His Leu 

145                 150                 155                 160 





Ser Ser Arg Asp Ser Gln Ser Arg Ser Val Ser Arg 

                165                 170         





<210>  188

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  188



Met Asp Pro Ala Arg Pro Leu Gly Leu Ser Ile Leu Leu Leu Phe Leu 

1               5                   10                  15      





Thr Glu Ala Ala Leu Gly Asp Ala Ala Gln Glu Pro Thr Gly Asn Asn 

            20                  25                  30          





Ala Glu Ile Cys Leu Leu Pro Leu Asp Tyr Gly Pro Cys Arg Ala Leu 

        35                  40                  45              





Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln Ser Cys Arg Gln Phe 

    50                  55                  60                  





Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn Phe Tyr Thr Trp Glu 

65                  70                  75                  80  





Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys Val Pro Lys Val Cys 

                85                  90                  95      





Arg Leu Gln Val Ser Val Asp Asp Gln Cys Glu Gly Ser Thr Glu Lys 

            100                 105                 110         





Tyr Phe Phe Asn Leu Ser Ser Met Thr Cys Glu Lys Phe Phe Ser Gly 

        115                 120                 125             





Gly Cys His Arg Asn Arg Ile Glu Asn Arg Phe Pro Asp Glu Ala Thr 

    130                 135                 140                 





Cys Met Gly Phe Cys Ala Pro Lys Lys Ile Pro Ser Phe Cys Tyr Ser 

145                 150                 155                 160 





Pro Lys Asp Glu Gly Leu Cys Ser Ala Asn Val Thr Arg Tyr Tyr Phe 

                165                 170                 175     





Asn Pro Arg Tyr Arg Thr Cys Asp Ala Phe Thr Tyr Thr Gly Cys Gly 

            180                 185                 190         





Gly Asn Asp Asn Asn Phe Val Ser Arg Glu Asp Cys Lys Arg Ala Cys 

        195                 200                 205             





Ala Lys Ala Leu Lys Lys Lys Lys Lys Met Pro Lys Leu Arg Phe Ala 

    210                 215                 220                 





Ser Arg Ile Arg Lys Ile Arg Lys Lys Gln Phe 

225                 230                 235 





<210>  189

<211>  224

<212>  PRT

<213>  Homo sapiens



<400>  189



Met Asp Pro Ala Arg Pro Leu Gly Leu Ser Ile Leu Leu Leu Phe Leu 

1               5                   10                  15      





Thr Glu Ala Ala Leu Gly Asp Ala Ala Gln Glu Pro Thr Asp Tyr Gly 

            20                  25                  30          





Pro Cys Arg Ala Leu Leu Leu Arg Tyr Tyr Tyr Asp Arg Tyr Thr Gln 

        35                  40                  45              





Ser Cys Arg Gln Phe Leu Tyr Gly Gly Cys Glu Gly Asn Ala Asn Asn 

    50                  55                  60                  





Phe Tyr Thr Trp Glu Ala Cys Asp Asp Ala Cys Trp Arg Ile Glu Lys 

65                  70                  75                  80  





Val Pro Lys Val Cys Arg Leu Gln Val Ser Val Asp Asp Gln Cys Glu 

                85                  90                  95      





Gly Ser Thr Glu Lys Tyr Phe Phe Asn Leu Ser Ser Met Thr Cys Glu 

            100                 105                 110         





Lys Phe Phe Ser Gly Gly Cys His Arg Asn Arg Ile Glu Asn Arg Phe 

        115                 120                 125             





Pro Asp Glu Ala Thr Cys Met Gly Phe Cys Ala Pro Lys Lys Ile Pro 

    130                 135                 140                 





Ser Phe Cys Tyr Ser Pro Lys Asp Glu Gly Leu Cys Ser Ala Asn Val 

145                 150                 155                 160 





Thr Arg Tyr Tyr Phe Asn Pro Arg Tyr Arg Thr Cys Asp Ala Phe Thr 

                165                 170                 175     





Tyr Thr Gly Cys Gly Gly Asn Asp Asn Asn Phe Val Ser Arg Glu Asp 

            180                 185                 190         





Cys Lys Arg Ala Cys Ala Lys Ala Leu Lys Lys Lys Lys Lys Met Pro 

        195                 200                 205             





Lys Leu Arg Phe Ala Ser Arg Ile Arg Lys Ile Arg Lys Lys Gln Phe 

    210                 215                 220                 





<210>  190

<211>  125

<212>  PRT

<213>  Homo sapiens



<400>  190



Met Pro Ser Glu Lys Thr Phe Lys Gln Arg Arg Thr Phe Glu Gln Arg 

1               5                   10                  15      





Val Glu Asp Val Arg Leu Ile Arg Glu Gln His Pro Thr Lys Ile Pro 

            20                  25                  30          





Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 

        35                  40                  45              





Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Ile 

    50                  55                  60                  





Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Ala Asn Gln Ala Phe Phe 

65                  70                  75                  80  





Leu Leu Val Asn Gly His Ser Met Val Ser Val Ser Thr Pro Ile Ser 

                85                  90                  95      





Glu Val Tyr Glu Ser Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 

            100                 105                 110         





Tyr Ala Ser Gln Glu Thr Phe Gly Met Lys Leu Ser Val 

        115                 120                 125 





<210>  191

<211>  403

<212>  PRT

<213>  Homo sapiens



<400>  191



Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 

1               5                   10                  15      





Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 

            20                  25                  30          





Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 

        35                  40                  45              





Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 

    50                  55                  60                  





Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 

65                  70                  75                  80  





Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 

                85                  90                  95      





Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 

            100                 105                 110         





Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 

        115                 120                 125             





Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 

    130                 135                 140                 





Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 

145                 150                 155                 160 





Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 

                165                 170                 175     





Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 

            180                 185                 190         





Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 

        195                 200                 205             





Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 

    210                 215                 220                 





Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 

225                 230                 235                 240 





Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 

                245                 250                 255     





Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 

            260                 265                 270         





Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 

        275                 280                 285             





Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 

    290                 295                 300                 





Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 

305                 310                 315                 320 





Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 

                325                 330                 335     





Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 

            340                 345                 350         





Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 

        355                 360                 365             





Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 

    370                 375                 380                 





Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 

385                 390                 395                 400 





Thr Lys Val 

            





<210>  192

<211>  576

<212>  PRT

<213>  Homo sapiens



<400>  192



Met Glu Arg Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 

1               5                   10                  15      





Ala Pro Gly Arg Gly Ser Glu Ser Pro Val Thr Ile Ser Arg Ala Gly 

            20                  25                  30          





Asn Ala Gly Glu Leu Val Ser Pro Leu Leu Leu Pro Pro Thr Arg Arg 

        35                  40                  45              





Arg Arg Arg Arg His Ile Gln Gly Pro Gly Pro Val Leu Asn Leu Pro 

    50                  55                  60                  





Ser Ala Ala Ala Ala Pro Pro Val Ala Arg Ala Pro Glu Ala Ala Gly 

65                  70                  75                  80  





Gly Gly Ser Arg Ser Glu Asp Tyr Ser Ser Ser Pro His Ser Ala Ala 

                85                  90                  95      





Ala Ala Ala Arg Pro Leu Ala Ala Glu Glu Lys Gln Ala Gln Ser Leu 

            100                 105                 110         





Gln Pro Ser Ser Ser Arg Arg Ser Ser His Tyr Pro Ala Ala Val Gln 

        115                 120                 125             





Ser Gln Ala Ala Ala Glu Arg Gly Ala Ser Ala Thr Ala Lys Ser Arg 

    130                 135                 140                 





Ala Ile Ser Ile Leu Gln Lys Lys Pro Arg His Gln Gln Leu Leu Pro 

145                 150                 155                 160 





Ser Leu Ser Ser Phe Phe Phe Ser His Arg Leu Pro Asp Met Thr Ala 

                165                 170                 175     





Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr Gln Glu Asp 

            180                 185                 190         





Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile Ile Ala Met 

        195                 200                 205             





Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn Asn Ile Asp 

    210                 215                 220                 





Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His Tyr Lys Ile 

225                 230                 235                 240 





Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys Phe Asn Cys 

                245                 250                 255     





Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro Gln Leu Glu 

            260                 265                 270         





Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu Ser Glu Asp 

        275                 280                 285             





Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys Gly Arg Thr 

    290                 295                 300                 





Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys Phe Leu Lys 

305                 310                 315                 320 





Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr Arg Asp Lys 

                325                 330                 335     





Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr Tyr Tyr Ser 

            340                 345                 350         





Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala Leu Leu Phe 

        355                 360                 365             





His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly Gly Thr Cys 

    370                 375                 380                 





Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile Tyr Ser Ser 

385                 390                 395                 400 





Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr Phe Glu Phe 

                405                 410                 415     





Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu Phe Phe His 

            420                 425                 430         





Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His Phe Trp Val 

        435                 440                 445             





Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu Lys Val Glu 

    450                 455                 460                 





Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu 

465                 470                 475                 480 





Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu Thr Lys Asn 

                485                 490                 495     





Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr Phe Ser Pro 

            500                 505                 510         





Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu Glu Pro Ser 

        515                 520                 525             





Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp Val Ser Asp 

    530                 535                 540                 





Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp Ser Asp Pro 

545                 550                 555                 560 





Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile Thr Lys Val 

                565                 570                 575     





<210>  193

<211>  175

<212>  PRT

<213>  Homo sapiens



<400>  193



Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 

1               5                   10                  15      





Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 

            20                  25                  30          





Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 

        35                  40                  45              





Asn Ile Asp Asp Val Val Ser Cys Ala Glu Arg His Tyr Asp Thr Ala 

    50                  55                  60                  





Lys Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro 

65                  70                  75                  80  





Pro Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp 

                85                  90                  95      





Leu Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly 

            100                 105                 110         





Lys Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly 

        115                 120                 125             





Lys Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg 

    130                 135                 140                 





Thr Arg Asp Lys Lys Ala Asp Pro Thr Gly Gly Ile Pro Asp Lys Gly 

145                 150                 155                 160 





Ile Ile Val Ile Gly Asp Gly Ser Ser Met Asp Val Ile Ala Pro 

                165                 170                 175 





<210>  194

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  194



Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 

1               5                   10                  15      





Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 

            20                  25                  30          





Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 

        35                  40                  45              





Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 

    50                  55                  60                  





Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 

65                  70                  75                  80  





Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 

                85                  90                  95      





Glu Asn Ser 

            





<210>  195

<211>  986

<212>  PRT

<213>  Homo sapiens



<400>  195



Met Ser Arg Ile Glu Ser Leu Thr Arg Ala Arg Ile Asp Arg Ser Arg 

1               5                   10                  15      





Glu Leu Ala Ser Lys Thr Arg Glu Lys Glu Lys Met Lys Glu Ala Lys 

            20                  25                  30          





Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr Thr Ile Ser Val Ser 

        35                  40                  45              





Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser Ile Thr Ala Lys Glu 

    50                  55                  60                  





Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile His Asn Arg Cys Lys 

65                  70                  75                  80  





Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln Lys Gln Gln Lys Ala 

                85                  90                  95      





Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser Val Ser Leu Arg Ser 

            100                 105                 110         





Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp 

        115                 120                 125             





Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu 

    130                 135                 140                 





Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile Ala Gly His Phe Asn 

145                 150                 155                 160 





Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Thr Asp 

                165                 170                 175     





Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val Glu Ser Leu Ile Asp 

            180                 185                 190         





Glu Ala Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp 

        195                 200                 205             





Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser 

    210                 215                 220                 





Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile 

225                 230                 235                 240 





Tyr Glu Leu Ile Gln Thr Glu Leu His His Val Arg Thr Leu Lys Ile 

                245                 250                 255     





Met Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu Leu His Leu Glu 

            260                 265                 270         





Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp 

        275                 280                 285             





Ile His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala 

    290                 295                 300                 





Leu Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His Arg Leu Gly Asp 

305                 310                 315                 320 





Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys 

                325                 330                 335     





Thr Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr 

            340                 345                 350         





Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys 

        355                 360                 365             





Val Thr Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile 

    370                 375                 380                 





Leu Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu Leu Ile Ser Arg 

385                 390                 395                 400 





Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Thr 

                405                 410                 415     





Thr Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly 

            420                 425                 430         





Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg 

        435                 440                 445             





Met Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys Gly Pro Phe Gly 

    450                 455                 460                 





Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu 

465                 470                 475                 480 





Trp Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met 

                485                 490                 495     





Thr Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe 

            500                 505                 510         





Pro Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val 

        515                 520                 525             





Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala 

    530                 535                 540                 





Pro Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg Asp Asp Arg Ser 

545                 550                 555                 560 





Thr Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr Cys Pro Ser Arg 

                565                 570                 575     





Glu Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala Tyr Leu Arg Arg 

            580                 585                 590         





Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu 

        595                 600                 605             





Arg Glu Lys Val Gly Leu Phe Ala Glu Met Thr His Phe Gln Ala Glu 

    610                 615                 620                 





Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu Pro Arg Gly Leu 

625                 630                 635                 640 





Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln 

                645                 650                 655     





Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro 

            660                 665                 670         





Gly Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala Leu Pro Leu Glu 

        675                 680                 685             





Pro Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr Ala Asn Gly Glu 

    690                 695                 700                 





Ala Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp 

705                 710                 715                 720 





Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu 

                725                 730                 735     





Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu 

            740                 745                 750         





Gln Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu Ala Arg Phe Pro 

        755                 760                 765             





Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp 

    770                 775                 780                 





Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln 

785                 790                 795                 800 





Ala Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu 

                805                 810                 815     





Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Thr Glu Ala 

            820                 825                 830         





Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu 

        835                 840                 845             





Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly 

    850                 855                 860                 





Gln Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val 

865                 870                 875                 880 





Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser 

                885                 890                 895     





Phe Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg Leu Asp Leu Pro 

            900                 905                 910         





Val Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln 

        915                 920                 925             





Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp 

    930                 935                 940                 





Thr Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser 

945                 950                 955                 960 





Pro Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu Glu Thr Glu Ser 

                965                 970                 975     





Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 

            980                 985     





<210>  196

<211>  985

<212>  PRT

<213>  Homo sapiens



<400>  196



Met Ser Arg Ile Glu Ser Leu Thr Arg Ala Arg Ile Asp Arg Ser Arg 

1               5                   10                  15      





Glu Leu Ala Ser Lys Thr Arg Glu Lys Glu Lys Met Lys Glu Ala Lys 

            20                  25                  30          





Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr Thr Ile Ser Val Ser 

        35                  40                  45              





Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser Ile Thr Ala Lys Glu 

    50                  55                  60                  





Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile His Asn Arg Cys Lys 

65                  70                  75                  80  





Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln Lys Gln Gln Lys Ala 

                85                  90                  95      





Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser Val Ser Leu Arg Ser 

            100                 105                 110         





Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala Ile Tyr Pro Ser Asp 

        115                 120                 125             





Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg Gly Arg Ser Ser Leu 

    130                 135                 140                 





Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile Ala Gly His Phe Asn 

145                 150                 155                 160 





Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu Ser Gln Ser Thr Asp 

                165                 170                 175     





Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val Glu Ser Leu Ile Asp 

            180                 185                 190         





Glu Glu Val Ile Tyr Ser Glu Leu Met Ser Asp Phe Glu Met Asp Glu 

        195                 200                 205             





Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala Val Asp Ser Ser Phe 

    210                 215                 220                 





Leu Gln Gln His Lys Lys Glu Val Met Lys Gln Gln Asp Val Ile Tyr 

225                 230                 235                 240 





Glu Leu Ile Gln Thr Glu Leu His His Val Arg Thr Leu Lys Ile Met 

                245                 250                 255     





Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu Leu His Leu Glu Pro 

            260                 265                 270         





Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp Glu Leu Ser Asp Ile 

        275                 280                 285             





His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg Arg Arg Gln Ala Leu 

    290                 295                 300                 





Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His Arg Leu Gly Asp Leu 

305                 310                 315                 320 





Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu Gln Met Cys Lys Thr 

                325                 330                 335     





Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala Leu Lys Leu Tyr Lys 

            340                 345                 350         





Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln Phe Ile Arg Lys Val 

        355                 360                 365             





Thr Arg Pro Ala Val Leu Lys Arg His Gly Val Gln Glu Cys Ile Leu 

    370                 375                 380                 





Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu Leu Ile Ser Arg Ile 

385                 390                 395                 400 





Leu Gln His Ser His Gly Ile Glu Glu Glu Arg Gln Asp Leu Thr Thr 

                405                 410                 415     





Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn Val Asp Glu Gly Ile 

            420                 425                 430         





Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu Ile Tyr Asn Arg Met 

        435                 440                 445             





Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys Gly Pro Phe Gly Arg 

    450                 455                 460                 





Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp Gly Cys Leu Leu Trp 

465                 470                 475                 480 





Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu Val Leu Leu Met Thr 

                485                 490                 495     





Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln Lys Tyr Ile Phe Pro 

            500                 505                 510         





Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln Asn Leu Ile Val Arg 

        515                 520                 525             





Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu Ile Ser Ala Ala Pro 

    530                 535                 540                 





Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg Asp Asp Arg Ser Thr 

545                 550                 555                 560 





Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr Cys Pro Ser Arg Glu 

                565                 570                 575     





Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala Tyr Leu Arg Arg Ile 

            580                 585                 590         





Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu Val Glu Leu Leu Arg 

        595                 600                 605             





Glu Lys Val Gly Leu Phe Ala Glu Met Thr His Phe Gln Ala Glu Glu 

    610                 615                 620                 





Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu Pro Arg Gly Leu Phe 

625                 630                 635                 640 





Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu Arg Leu Leu Gln Asp 

                645                 650                 655     





Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu Leu Val Gly Pro Gly 

            660                 665                 670         





Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala Leu Pro Leu Glu Pro 

        675                 680                 685             





Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr Ala Asn Gly Glu Ala 

    690                 695                 700                 





Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg Ala Asp Ser Asp Ser 

705                 710                 715                 720 





Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg Ser Pro Gln Glu Glu 

                725                 730                 735     





Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu Leu His Gly Leu Gln 

            740                 745                 750         





Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu Ala Arg Phe Pro Glu 

        755                 760                 765             





Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala Asn Ser Arg Asp Gly 

    770                 775                 780                 





Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala Pro Glu Lys Gln Ala 

785                 790                 795                 800 





Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala Leu Leu Gln Glu Glu 

                805                 810                 815     





Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg Ala Thr Glu Ala Gly 

            820                 825                 830         





Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln Ala Arg Ala Leu Leu 

        835                 840                 845             





Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu Ala Ala Leu Gly Gln 

    850                 855                 860                 





Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala Arg Arg Pro Val Asp 

865                 870                 875                 880 





Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala Leu Tyr Leu Ser Phe 

                885                 890                 895     





Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg Leu Asp Leu Pro Val 

            900                 905                 910         





Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp Arg Glu Arg Gln Glu 

        915                 920                 925             





Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser Ser Asp Pro Asp Thr 

    930                 935                 940                 





Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser Pro Pro His Ser Pro 

945                 950                 955                 960 





Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu Glu Thr Glu Ser Arg 

                965                 970                 975     





Asp Gly Glu Ala Val Ala Ser Glu Ser 

            980                 985 





<210>  197

<211>  958

<212>  PRT

<213>  Homo sapiens



<400>  197



Met Lys Glu Ala Lys Asp Ala Arg Tyr Thr Asn Gly His Leu Phe Thr 

1               5                   10                  15      





Thr Ile Ser Val Ser Gly Met Thr Met Cys Tyr Ala Cys Asn Lys Ser 

            20                  25                  30          





Ile Thr Ala Lys Glu Ala Leu Ile Cys Pro Thr Cys Asn Val Thr Ile 

        35                  40                  45              





His Asn Arg Cys Lys Asp Thr Leu Ala Asn Cys Thr Lys Val Lys Gln 

    50                  55                  60                  





Lys Gln Gln Lys Ala Ala Leu Leu Lys Asn Asn Thr Ala Leu Gln Ser 

65                  70                  75                  80  





Val Ser Leu Arg Ser Lys Thr Thr Ile Arg Glu Arg Pro Ser Ser Ala 

                85                  90                  95      





Ile Tyr Pro Ser Asp Ser Phe Arg Gln Ser Leu Leu Gly Ser Arg Arg 

            100                 105                 110         





Gly Arg Ser Ser Leu Ser Leu Ala Lys Ser Val Ser Thr Thr Asn Ile 

        115                 120                 125             





Ala Gly His Phe Asn Asp Glu Ser Pro Leu Gly Leu Arg Arg Ile Leu 

    130                 135                 140                 





Ser Gln Ser Thr Asp Ser Leu Asn Met Arg Asn Arg Thr Leu Ser Val 

145                 150                 155                 160 





Glu Ser Leu Ile Asp Glu Glu Val Ile Tyr Ser Glu Leu Met Ser Asp 

                165                 170                 175     





Phe Glu Met Asp Glu Lys Asp Phe Ala Ala Asp Ser Trp Ser Leu Ala 

            180                 185                 190         





Val Asp Ser Ser Phe Leu Gln Gln His Lys Lys Glu Val Met Lys Gln 

        195                 200                 205             





Gln Asp Val Ile Tyr Glu Leu Ile Gln Thr Glu Leu His His Val Arg 

    210                 215                 220                 





Thr Leu Lys Ile Met Thr Arg Leu Phe Arg Thr Gly Met Leu Glu Glu 

225                 230                 235                 240 





Leu His Leu Glu Pro Gly Val Val Gln Gly Leu Phe Pro Cys Val Asp 

                245                 250                 255     





Glu Leu Ser Asp Ile His Thr Arg Phe Leu Ser Gln Leu Leu Glu Arg 

            260                 265                 270         





Arg Arg Gln Ala Leu Cys Pro Gly Ser Thr Arg Asn Phe Val Ile His 

        275                 280                 285             





Arg Leu Gly Asp Leu Leu Ile Ser Gln Phe Ser Gly Pro Ser Ala Glu 

    290                 295                 300                 





Gln Met Cys Lys Thr Tyr Ser Glu Phe Cys Ser Arg His Ser Lys Ala 

305                 310                 315                 320 





Leu Lys Leu Tyr Lys Glu Leu Tyr Ala Arg Asp Lys Arg Phe Gln Gln 

                325                 330                 335     





Phe Ile Arg Lys Val Thr Arg Pro Ala Val Leu Lys Arg His Gly Val 

            340                 345                 350         





Gln Glu Cys Ile Leu Leu Val Thr Gln Arg Ile Thr Lys Tyr Pro Leu 

        355                 360                 365             





Leu Ile Ser Arg Ile Leu Gln His Ser His Gly Ile Glu Glu Glu Arg 

    370                 375                 380                 





Gln Asp Leu Thr Thr Ala Leu Gly Leu Val Lys Glu Leu Leu Ser Asn 

385                 390                 395                 400 





Val Asp Glu Gly Ile Tyr Gln Leu Glu Lys Gly Ala Arg Leu Gln Glu 

                405                 410                 415     





Ile Tyr Asn Arg Met Asp Pro Arg Ala Gln Thr Pro Val Pro Gly Lys 

            420                 425                 430         





Gly Pro Phe Gly Arg Glu Glu Leu Leu Arg Arg Lys Leu Ile His Asp 

        435                 440                 445             





Gly Cys Leu Leu Trp Lys Thr Ala Thr Gly Arg Phe Lys Asp Val Leu 

    450                 455                 460                 





Val Leu Leu Met Thr Asp Val Leu Val Phe Leu Gln Glu Lys Asp Gln 

465                 470                 475                 480 





Lys Tyr Ile Phe Pro Thr Leu Asp Lys Pro Ser Val Val Ser Leu Gln 

                485                 490                 495     





Asn Leu Ile Val Arg Asp Ile Ala Asn Gln Glu Lys Gly Met Phe Leu 

            500                 505                 510         





Ile Ser Ala Ala Pro Pro Glu Met Tyr Glu Val His Thr Ala Ser Arg 

        515                 520                 525             





Asp Asp Arg Ser Thr Trp Ile Arg Val Ile Gln Gln Ser Val Arg Thr 

    530                 535                 540                 





Cys Pro Ser Arg Glu Asp Phe Pro Leu Ile Glu Thr Glu Asp Glu Ala 

545                 550                 555                 560 





Tyr Leu Arg Arg Ile Lys Met Glu Leu Gln Gln Lys Asp Arg Ala Leu 

                565                 570                 575     





Val Glu Leu Leu Arg Glu Lys Val Gly Leu Phe Ala Glu Met Thr His 

            580                 585                 590         





Phe Gln Ala Glu Glu Asp Gly Gly Ser Gly Met Ala Leu Pro Thr Leu 

        595                 600                 605             





Pro Arg Gly Leu Phe Arg Ser Glu Ser Leu Glu Ser Pro Arg Gly Glu 

    610                 615                 620                 





Arg Leu Leu Gln Asp Ala Ile Arg Glu Val Glu Gly Leu Lys Asp Leu 

625                 630                 635                 640 





Leu Val Gly Pro Gly Val Glu Leu Leu Leu Thr Pro Arg Glu Pro Ala 

                645                 650                 655     





Leu Pro Leu Glu Pro Asp Ser Gly Gly Asn Thr Ser Pro Gly Val Thr 

            660                 665                 670         





Ala Asn Gly Glu Ala Arg Thr Phe Asn Gly Ser Ile Glu Leu Cys Arg 

        675                 680                 685             





Ala Asp Ser Asp Ser Ser Gln Arg Asp Arg Asn Gly Asn Gln Leu Arg 

    690                 695                 700                 





Ser Pro Gln Glu Glu Ala Leu Gln Arg Leu Val Asn Leu Tyr Gly Leu 

705                 710                 715                 720 





Leu His Gly Leu Gln Ala Ala Val Ala Gln Gln Asp Thr Leu Met Glu 

                725                 730                 735     





Ala Arg Phe Pro Glu Gly Pro Glu Arg Arg Glu Lys Leu Cys Arg Ala 

            740                 745                 750         





Asn Ser Arg Asp Gly Glu Ala Gly Arg Ala Gly Ala Ala Pro Val Ala 

        755                 760                 765             





Pro Glu Lys Gln Ala Thr Glu Leu Ala Leu Leu Gln Arg Gln His Ala 

    770                 775                 780                 





Leu Leu Gln Glu Glu Leu Arg Arg Cys Arg Arg Leu Gly Glu Glu Arg 

785                 790                 795                 800 





Ala Thr Glu Ala Gly Ser Leu Glu Ala Arg Leu Arg Glu Ser Glu Gln 

                805                 810                 815     





Ala Arg Ala Leu Leu Glu Arg Glu Ala Glu Glu Ala Arg Arg Gln Leu 

            820                 825                 830         





Ala Ala Leu Gly Gln Thr Glu Pro Leu Pro Ala Glu Ala Pro Trp Ala 

        835                 840                 845             





Arg Arg Pro Val Asp Pro Arg Arg Arg Ser Leu Pro Ala Gly Asp Ala 

    850                 855                 860                 





Leu Tyr Leu Ser Phe Asn Pro Pro Gln Pro Ser Arg Gly Thr Asp Arg 

865                 870                 875                 880 





Leu Asp Leu Pro Val Thr Thr Arg Ser Val His Arg Asn Phe Glu Asp 

                885                 890                 895     





Arg Glu Arg Gln Glu Leu Gly Ser Pro Glu Glu Arg Leu Gln Asp Ser 

            900                 905                 910         





Ser Asp Pro Asp Thr Gly Ser Glu Glu Glu Gly Ser Ser Arg Leu Ser 

        915                 920                 925             





Pro Pro His Ser Pro Arg Asp Phe Thr Arg Met Gln Asp Ile Pro Glu 

    930                 935                 940                 





Glu Thr Glu Ser Arg Asp Gly Glu Ala Val Ala Ser Glu Ser 

945                 950                 955             





<210>  198

<211>  480

<212>  PRT

<213>  Homo sapiens



<400>  198



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

        195                 200                 205             





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

    210                 215                 220                 





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

225                 230                 235                 240 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

                245                 250                 255     





Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 

            260                 265                 270         





Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 

        275                 280                 285             





Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 

    290                 295                 300                 





Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 

305                 310                 315                 320 





Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 

                325                 330                 335     





Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 

            340                 345                 350         





Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 

        355                 360                 365             





Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 

    370                 375                 380                 





Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 

385                 390                 395                 400 





Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 

                405                 410                 415     





His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 

            420                 425                 430         





Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 

        435                 440                 445             





Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 

    450                 455                 460                 





Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 

465                 470                 475                 480 





<210>  199

<211>  221

<212>  PRT

<213>  Homo sapiens



<400>  199



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Met Ile Thr Pro Tyr Ala 

        195                 200                 205             





His Cys Pro Asp Leu Lys Ile Leu Gly Asn Cys Ser Met 

    210                 215                 220     





<210>  200

<211>  366

<212>  PRT

<213>  Homo sapiens



<400>  200



Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

1               5                   10                  15      





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

            20                  25                  30          





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

        35                  40                  45              





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

    50                  55                  60                  





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

65                  70                  75                  80  





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

                85                  90                  95      





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

            100                 105                 110         





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

        115                 120                 125             





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

    130                 135                 140                 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

145                 150                 155                 160 





Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 

                165                 170                 175     





Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 

            180                 185                 190         





Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 

        195                 200                 205             





Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 

    210                 215                 220                 





Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 

225                 230                 235                 240 





Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 

                245                 250                 255     





Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 

            260                 265                 270         





Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 

        275                 280                 285             





Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 

    290                 295                 300                 





Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 

305                 310                 315                 320 





His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 

                325                 330                 335     





Gln Glu Arg Gly Thr Ile Pro Gly Ser Gly Ile Thr Glu Ser Lys Asp 

            340                 345                 350         





Met His Phe Ser Ser Leu Gly Cys Ile Leu Leu Asp Val Leu 

        355                 360                 365     





<210>  201

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  201



Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp Cys Ile Gly 

1               5                   10                  15      





Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr Ser Leu Gly Tyr Glu 

            20                  25                  30          





Val Gln Lys Phe Leu His Leu Ser Met His Gly Ile Ser Gln Ile Leu 

        35                  40                  45              





Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp Tyr Asp Ser Phe Val 

    50                  55                  60                  





Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser Val Tyr Gly Val Asp 

65                  70                  75                  80  





Gln Thr His Ser Gly Leu Pro Leu His His Ile Arg Arg Met Phe Met 

                85                  90                  95      





Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro Lys Met Phe Phe Ile 

            100                 105                 110         





Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu Asp Ser Ser Leu Leu 

        115                 120                 125             





Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu Phe Lys Ala Gln Lys 

    130                 135                 140                 





Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp Phe Phe Trp Ser Leu 

145                 150                 155                 160 





Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser His Ser Ser Pro Ser 

                165                 170                 175     





Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg Gln Glu Arg Lys Arg 

            180                 185                 190         





Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly Tyr Met Tyr Asp Trp 

        195                 200                 205             





Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr Val Trp Leu Gln His 

    210                 215                 220                 





Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 

225                 230                 235 





<210>  202

<211>  449

<212>  PRT

<213>  Homo sapiens



<400>  202



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

        195                 200                 205             





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

    210                 215                 220                 





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

225                 230                 235                 240 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

                245                 250                 255     





Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 

            260                 265                 270         





Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 

        275                 280                 285             





Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 

    290                 295                 300                 





Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 

305                 310                 315                 320 





Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 

                325                 330                 335     





Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 

            340                 345                 350         





Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 

        355                 360                 365             





Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 

    370                 375                 380                 





Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 

385                 390                 395                 400 





Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 

                405                 410                 415     





His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 

            420                 425                 430         





Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 

        435                 440                 445             





Leu 

    





<210>  203

<211>  442

<212>  PRT

<213>  Homo sapiens



<400>  203



Met Leu Glu Arg Pro Pro Val Cys Ser Lys Val Asp Val Val Pro Pro 

1               5                   10                  15      





Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly Lys Leu Ser 

            20                  25                  30          





Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg Phe Asp Leu 

        35                  40                  45              





Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu Thr His Leu 

    50                  55                  60                  





Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu Met Ala Glu 

65                  70                  75                  80  





Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu Ile Phe Leu 

                85                  90                  95      





Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu Lys Ser Phe 

            100                 105                 110         





Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val Ala Pro Asp 

        115                 120                 125             





Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His Arg Ile Asp 

    130                 135                 140                 





Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln Gly Ala Gly 

145                 150                 155                 160 





Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys Ser Leu Lys 

                165                 170                 175     





Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser Lys Glu Gln 

            180                 185                 190         





Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val Lys Lys Ser 

        195                 200                 205             





Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro Glu Glu Arg 

    210                 215                 220                 





Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp Cys 

225                 230                 235                 240 





Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr Ser Leu Gly 

                245                 250                 255     





Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly Ile Ser Gln 

            260                 265                 270         





Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp Tyr Asp Ser 

        275                 280                 285             





Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser Val Tyr Gly 

    290                 295                 300                 





Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile Arg Arg Met 

305                 310                 315                 320 





Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro Lys Met Phe 

                325                 330                 335     





Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu Asp Ser Ser 

            340                 345                 350         





Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu Phe Lys Ala 

        355                 360                 365             





Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp Phe Phe Trp 

    370                 375                 380                 





Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser His Ser Ser 

385                 390                 395                 400 





Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg Gln Glu Arg 

                405                 410                 415     





Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly Tyr Met Tyr 

            420                 425                 430         





Asp Ser Leu Glu His Thr Gly Gly Arg Tyr 

        435                 440         





<210>  204

<211>  348

<212>  PRT

<213>  Homo sapiens



<400>  204



Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

1               5                   10                  15      





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

            20                  25                  30          





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

        35                  40                  45              





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

    50                  55                  60                  





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

65                  70                  75                  80  





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

                85                  90                  95      





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Glu Glu Pro Val Lys Lys 

            100                 105                 110         





Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro Glu Glu 

        115                 120                 125             





Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp 

    130                 135                 140                 





Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr Ser Leu 

145                 150                 155                 160 





Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly Ile Ser 

                165                 170                 175     





Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp Tyr Asp 

            180                 185                 190         





Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser Val Tyr 

        195                 200                 205             





Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile Arg Arg 

    210                 215                 220                 





Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro Lys Met 

225                 230                 235                 240 





Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu Asp Ser 

                245                 250                 255     





Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu Phe Lys 

            260                 265                 270         





Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp Phe Phe 

        275                 280                 285             





Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser His Ser 

    290                 295                 300                 





Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg Gln Glu 

305                 310                 315                 320 





Arg Gly Thr Ile Pro Gly Ser Gly Ile Thr Glu Ser Lys Asp Met His 

                325                 330                 335     





Phe Ser Ser Leu Gly Cys Ile Leu Leu Asp Val Leu 

            340                 345             





<210>  205

<211>  445

<212>  PRT

<213>  Homo sapiens



<400>  205



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Ser Ile Pro Glu Glu Arg 

        195                 200                 205             





Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp Cys 

    210                 215                 220                 





Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr Ser Leu Gly 

225                 230                 235                 240 





Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly Ile Ser Gln 

                245                 250                 255     





Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp Tyr Asp Ser 

            260                 265                 270         





Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser Val Tyr Gly 

        275                 280                 285             





Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile Arg Arg Met 

    290                 295                 300                 





Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro Lys Met Phe 

305                 310                 315                 320 





Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu Asp Ser Ser 

                325                 330                 335     





Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu Phe Lys Ala 

            340                 345                 350         





Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp Phe Phe Trp 

        355                 360                 365             





Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser His Ser Ser 

    370                 375                 380                 





Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg Gln Glu Arg 

385                 390                 395                 400 





Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly Tyr Met Tyr 

                405                 410                 415     





Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr Val Trp Leu 

            420                 425                 430         





Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 

        435                 440                 445 





<210>  206

<211>  270

<212>  PRT

<213>  Homo sapiens



<400>  206



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Ser Ile Pro Glu Glu Arg 

        195                 200                 205             





Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile Ile Asp Cys 

    210                 215                 220                 





Ile Gly Asn Glu Thr Glu Leu Cys Gly Val Arg Gly Pro Ala Gly Gly 

225                 230                 235                 240 





Gln Gln Pro Leu Gly Gly Gly Trp Ala Ser Asp Glu Glu Cys Gly Ile 

                245                 250                 255     





Gln Gly Ser Glu Ala Arg Ala Val His Ser Ser Pro Arg Ser 

            260                 265                 270 





<210>  207

<211>  300

<212>  PRT

<213>  Homo sapiens



<400>  207



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

        195                 200                 205             





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

    210                 215                 220                 





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

225                 230                 235                 240 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

                245                 250                 255     





Ile Asp Cys Ile Gly Asn Glu Thr Glu Asn Ala His Ser Trp Ile Phe 

            260                 265                 270         





Thr Leu Asn Ser Met Ala Thr Cys Met Ile Gly Thr Ala Glu Phe Leu 

        275                 280                 285             





Pro Arg Arg Asn Ile Met Phe Gly Cys Ser Thr Leu 

    290                 295                 300 





<210>  208

<211>  462

<212>  PRT

<213>  Homo sapiens



<400>  208



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

        195                 200                 205             





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

    210                 215                 220                 





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

225                 230                 235                 240 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

                245                 250                 255     





Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 

            260                 265                 270         





Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 

        275                 280                 285             





Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 

    290                 295                 300                 





Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 

305                 310                 315                 320 





Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 

                325                 330                 335     





Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 

            340                 345                 350         





Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 

        355                 360                 365             





Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 

    370                 375                 380                 





Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 

385                 390                 395                 400 





Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 

                405                 410                 415     





His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 

            420                 425                 430         





Gln Glu Arg Gly Thr Ile Pro Gly Ser Gly Ile Thr Glu Ser Lys Asp 

        435                 440                 445             





Met His Phe Ser Ser Leu Gly Cys Ile Leu Leu Asp Val Leu 

    450                 455                 460         





<210>  209

<211>  292

<212>  PRT

<213>  Homo sapiens



<400>  209



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

        195                 200                 205             





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

    210                 215                 220                 





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

225                 230                 235                 240 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

                245                 250                 255     





Ile Asp Cys Ile Gly Asn Glu Thr Gly Trp Ser Ala Met Ala Gln Ser 

            260                 265                 270         





Gln Leu Thr Ala Ile Ser Thr Ser Gln Val Gln Ala Ile Leu Leu Pro 

        275                 280                 285             





Gln Pro Pro Glu 

    290         





<210>  210

<211>  202

<212>  PRT

<213>  Homo sapiens



<400>  210



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg 

        195                 200         





<210>  211

<211>  435

<212>  PRT

<213>  Homo sapiens



<400>  211



Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 

1               5                   10                  15      





Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 

            20                  25                  30          





Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 

        35                  40                  45              





Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 

    50                  55                  60                  





Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 

65                  70                  75                  80  





Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 

                85                  90                  95      





Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

            100                 105                 110         





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

        115                 120                 125             





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

    130                 135                 140                 





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

145                 150                 155                 160 





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

                165                 170                 175     





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

            180                 185                 190         





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

        195                 200                 205             





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

    210                 215                 220                 





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

225                 230                 235                 240 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

                245                 250                 255     





Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 

            260                 265                 270         





Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 

        275                 280                 285             





Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 

    290                 295                 300                 





Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 

305                 310                 315                 320 





Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 

                325                 330                 335     





Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 

            340                 345                 350         





Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 

        355                 360                 365             





Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 

    370                 375                 380                 





Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 

385                 390                 395                 400 





Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 

                405                 410                 415     





His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 

            420                 425                 430         





Gln Glu Arg 

        435 





<210>  212

<211>  384

<212>  PRT

<213>  Homo sapiens



<400>  212



Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 

1               5                   10                  15      





Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 

            20                  25                  30          





Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 

        35                  40                  45              





Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 

    50                  55                  60                  





Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 

65                  70                  75                  80  





Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 

                85                  90                  95      





Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 

            100                 105                 110         





Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 

        115                 120                 125             





Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 

    130                 135                 140                 





Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 

145                 150                 155                 160 





Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 

                165                 170                 175     





Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 

            180                 185                 190         





Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 

        195                 200                 205             





Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 

    210                 215                 220                 





Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 

225                 230                 235                 240 





Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 

                245                 250                 255     





Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 

            260                 265                 270         





Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 

        275                 280                 285             





Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 

    290                 295                 300                 





Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 

305                 310                 315                 320 





His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 

                325                 330                 335     





Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 

            340                 345                 350         





Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 

        355                 360                 365             





Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 

    370                 375                 380                 





<210>  213

<211>  287

<212>  PRT

<213>  Homo sapiens



<400>  213



Met Glu Leu Glu Arg Ile Val Ser Ala Ala Leu Leu Ala Phe Val Gln 

1               5                   10                  15      





Thr His Leu Pro Glu Ala Asp Leu Ser Gly Leu Asp Glu Val Ile Phe 

            20                  25                  30          





Ser Tyr Val Leu Gly Val Leu Glu Asp Leu Gly Pro Ser Gly Pro Ser 

        35                  40                  45              





Glu Glu Asn Phe Asp Met Glu Ala Phe Thr Glu Met Met Glu Ala Tyr 

    50                  55                  60                  





Val Pro Gly Phe Ala His Ile Pro Arg Gly Thr Ile Gly Asp Met Met 

65                  70                  75                  80  





Gln Lys Leu Ser Gly Gln Leu Ser Asp Ala Arg Asn Lys Glu Asn Leu 

                85                  90                  95      





Gln Pro Gln Ser Ser Gly Val Gln Gly Gln Val Pro Ile Ser Pro Glu 

            100                 105                 110         





Pro Leu Gln Arg Pro Glu Met Leu Lys Glu Glu Thr Arg Ser Ser Ala 

        115                 120                 125             





Ala Ala Ala Ala Asp Thr Gln Asp Glu Ala Thr Gly Ala Glu Glu Glu 

    130                 135                 140                 





Leu Leu Pro Gly Val Asp Val Leu Leu Glu Val Phe Pro Thr Cys Ser 

145                 150                 155                 160 





Val Glu Gln Ala Gln Trp Val Leu Ala Lys Ala Arg Gly Asp Leu Glu 

                165                 170                 175     





Glu Ala Val Gln Met Leu Val Glu Gly Lys Glu Glu Gly Pro Ala Ala 

            180                 185                 190         





Trp Glu Gly Pro Asn Gln Asp Leu Pro Arg Arg Leu Arg Gly Pro Gln 

        195                 200                 205             





Lys Asp Glu Leu Lys Ser Phe Ile Leu Gln Lys Tyr Met Met Val Asp 

    210                 215                 220                 





Ser Ala Glu Asp Gln Lys Ile His Arg Pro Met Ala Pro Lys Glu Ala 

225                 230                 235                 240 





Pro Lys Lys Leu Ile Arg Tyr Ile Asp Asn Gln Val Val Ser Thr Lys 

                245                 250                 255     





Gly Glu Arg Phe Lys Asp Val Arg Asn Pro Glu Ala Glu Glu Met Lys 

            260                 265                 270         





Ala Thr Tyr Ile Asn Leu Lys Pro Ala Arg Lys Tyr Arg Phe His 

        275                 280                 285         





<210>  214

<211>  1430

<212>  PRT

<213>  Homo sapiens



<400>  214



Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 

1               5                   10                  15      





Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 

            20                  25                  30          





Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 

        35                  40                  45              





Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 

    50                  55                  60                  





Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 

65                  70                  75                  80  





Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 

                85                  90                  95      





Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 

            100                 105                 110         





Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 

        115                 120                 125             





Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 

    130                 135                 140                 





Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 

145                 150                 155                 160 





Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 

                165                 170                 175     





Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 

            180                 185                 190         





Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 

        195                 200                 205             





Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 

    210                 215                 220                 





Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 

225                 230                 235                 240 





Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 

                245                 250                 255     





Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 

            260                 265                 270         





Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 

        275                 280                 285             





Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 

    290                 295                 300                 





Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 

305                 310                 315                 320 





Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 

                325                 330                 335     





Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 

            340                 345                 350         





Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 

        355                 360                 365             





Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 

    370                 375                 380                 





Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 

385                 390                 395                 400 





Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 

                405                 410                 415     





Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 

            420                 425                 430         





Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 

        435                 440                 445             





Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 

    450                 455                 460                 





Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 

465                 470                 475                 480 





Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 

                485                 490                 495     





Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 

            500                 505                 510         





Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 

        515                 520                 525             





Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 

    530                 535                 540                 





His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 

545                 550                 555                 560 





Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 

                565                 570                 575     





Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 

            580                 585                 590         





Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 

        595                 600                 605             





Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 

    610                 615                 620                 





Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 

625                 630                 635                 640 





Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 

                645                 650                 655     





His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 

            660                 665                 670         





Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 

        675                 680                 685             





Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 

    690                 695                 700                 





Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 

705                 710                 715                 720 





Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 

                725                 730                 735     





Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 

            740                 745                 750         





Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 

        755                 760                 765             





Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 

    770                 775                 780                 





His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 

785                 790                 795                 800 





Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 

                805                 810                 815     





Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 

            820                 825                 830         





Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 

        835                 840                 845             





Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 

    850                 855                 860                 





Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 

865                 870                 875                 880 





Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg 

                885                 890                 895     





Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys 

            900                 905                 910         





Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 

        915                 920                 925             





Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 

    930                 935                 940                 





Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 

945                 950                 955                 960 





Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp 

                965                 970                 975     





Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 

            980                 985                 990         





Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 

        995                 1000                 1005             





Arg Arg  Ile Ala Gln Gln Leu  His Ser Thr Gly Glu  Ile Asn Ile 

    1010                 1015                 1020             





Met Gln  Ser Glu Thr Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 

    1025                 1030                 1035             





Trp Leu  Cys Thr Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Thr 

    1040                 1045                 1050             





Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Thr  Val Glu Asp 

    1055                 1060                 1065             





Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 

    1070                 1075                 1080             





Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 

    1085                 1090                 1095             





Thr Met  Val Asp Val Pro Ala  Leu Ile Lys Thr Asp  Asn Leu His 

    1100                 1105                 1110             





Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 

    1115                 1120                 1125             





Val Arg  Ile Val Pro Val Glu  His Leu Thr Pro Phe  Pro Cys Gly 

    1130                 1135                 1140             





Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 

    1145                 1150                 1155             





Gln Ser  Thr Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 

    1160                 1165                 1170             





Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 

    1175                 1180                 1185             





Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Thr 

    1190                 1195                 1200             





Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Thr 

    1205                 1210                 1215             





Ile Glu  Asn Val Met Ala Thr  Thr Leu Pro Gly Leu  Leu Thr Val 

    1220                 1225                 1230             





Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 

    1235                 1240                 1245             





Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Thr Leu 

    1250                 1255                 1260             





Lys Glu  Thr Ser Leu Thr Asn  Thr Met Gly Gly Tyr  Lys Glu Ser 

    1265                 1270                 1275             





Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 

    1280                 1285                 1290             





Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 

    1295                 1300                 1305             





Thr Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 

    1310                 1315                 1320             





Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 

    1325                 1330                 1335             





Leu Val  Ala Lys Tyr Asn Thr  Ser Asn Gly Ala Pro  Lys Asp Phe 

    1340                 1345                 1350             





Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Thr Thr Tyr 

    1355                 1360                 1365             





Pro Glu  Ser Thr Val Gly Thr  Leu Met Ser Lys Leu  Arg Glu Leu 

    1370                 1375                 1380             





Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 

    1385                 1390                 1395             





Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 

    1400                 1405                 1410             





Ser Cys  Asn Ser Gly Thr Ser  Tyr Asn Ser Ile Ser  Ser Val Val 

    1415                 1420                 1425             





Ser Arg  

    1430 





<210>  215

<211>  337

<212>  PRT

<213>  Homo sapiens



<400>  215



Met Ala Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln 

1               5                   10                  15      





Leu Leu Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu 

            20                  25                  30          





Glu Thr Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala 

        35                  40                  45              





Lys Ala Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu 

    50                  55                  60                  





Gly Glu Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile 

65                  70                  75                  80  





Val Glu Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys 

                85                  90                  95      





Asp Gly His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu 

            100                 105                 110         





Val Ile Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp 

        115                 120                 125             





Arg His Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met 

    130                 135                 140                 





Pro Ile Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser 

145                 150                 155                 160 





Asn Lys Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile 

                165                 170                 175     





Leu Asp Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala 

            180                 185                 190         





Leu Thr Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln 

        195                 200                 205             





His Glu His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His 

    210                 215                 220                 





Arg Gly Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro 

225                 230                 235                 240 





Arg Ile Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr 

                245                 250                 255     





Leu Val Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg 

            260                 265                 270         





Arg Arg Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser 

        275                 280                 285             





Pro Leu Ala Ser Lys Pro Thr Gly Arg Asn Leu His Ala Gly Pro Val 

    290                 295                 300                 





Ser Pro Ala Gly Val Gly Phe Arg Thr Leu Ser Phe Gln Gly Leu Gly 

305                 310                 315                 320 





Gly Lys Gly Val Val Phe Gly Ser Leu Gly Leu Tyr Trp Thr Leu Trp 

                325                 330                 335     





Pro 

    





<210>  216

<211>  1440

<212>  PRT

<213>  Homo sapiens



<400>  216



Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 

1               5                   10                  15      





Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 

            20                  25                  30          





Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 

        35                  40                  45              





Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 

    50                  55                  60                  





Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 

65                  70                  75                  80  





Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 

                85                  90                  95      





Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 

            100                 105                 110         





Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 

        115                 120                 125             





Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 

    130                 135                 140                 





Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 

145                 150                 155                 160 





Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 

                165                 170                 175     





Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 

            180                 185                 190         





Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 

        195                 200                 205             





Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 

    210                 215                 220                 





Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 

225                 230                 235                 240 





Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 

                245                 250                 255     





Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 

            260                 265                 270         





Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 

        275                 280                 285             





Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 

    290                 295                 300                 





Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 

305                 310                 315                 320 





Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 

                325                 330                 335     





Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 

            340                 345                 350         





Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 

        355                 360                 365             





Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 

    370                 375                 380                 





Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 

385                 390                 395                 400 





Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 

                405                 410                 415     





Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 

            420                 425                 430         





Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 

        435                 440                 445             





Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 

    450                 455                 460                 





Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 

465                 470                 475                 480 





Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 

                485                 490                 495     





Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 

            500                 505                 510         





Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 

        515                 520                 525             





Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 

    530                 535                 540                 





His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 

545                 550                 555                 560 





Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 

                565                 570                 575     





Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 

            580                 585                 590         





Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 

        595                 600                 605             





Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 

    610                 615                 620                 





Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 

625                 630                 635                 640 





Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 

                645                 650                 655     





His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 

            660                 665                 670         





Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 

        675                 680                 685             





Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 

    690                 695                 700                 





Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 

705                 710                 715                 720 





Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 

                725                 730                 735     





Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 

            740                 745                 750         





Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 

        755                 760                 765             





Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 

    770                 775                 780                 





His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 

785                 790                 795                 800 





Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 

                805                 810                 815     





Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 

            820                 825                 830         





Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 

        835                 840                 845             





Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 

    850                 855                 860                 





Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 

865                 870                 875                 880 





Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg 

                885                 890                 895     





Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys 

            900                 905                 910         





Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 

        915                 920                 925             





Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 

    930                 935                 940                 





Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 

945                 950                 955                 960 





Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp 

                965                 970                 975     





Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 

            980                 985                 990         





Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 

        995                 1000                 1005             





Arg Arg  Ile Ala Gln Gln Leu  His Ser Thr Gly Glu  Ile Asn Ile 

    1010                 1015                 1020             





Met Gln  Ser Glu Thr Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 

    1025                 1030                 1035             





Trp Leu  Cys Thr Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Thr 

    1040                 1045                 1050             





Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Thr  Val Glu Asp 

    1055                 1060                 1065             





Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 

    1070                 1075                 1080             





Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 

    1085                 1090                 1095             





Thr Met  Val Asp Val Pro Ala  Leu Ile Lys Thr Asp  Asn Leu His 

    1100                 1105                 1110             





Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 

    1115                 1120                 1125             





Val Arg  Ile Val Pro Val Glu  His Leu Thr Pro Phe  Pro Cys Gly 

    1130                 1135                 1140             





Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 

    1145                 1150                 1155             





Gln Ser  Thr Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 

    1160                 1165                 1170             





Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 

    1175                 1180                 1185             





Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Thr 

    1190                 1195                 1200             





Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Thr 

    1205                 1210                 1215             





Ile Glu  Asn Val Met Ala Thr  Thr Leu Pro Gly Leu  Leu Thr Val 

    1220                 1225                 1230             





Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 

    1235                 1240                 1245             





Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Thr Leu 

    1250                 1255                 1260             





Lys Glu  Thr Ser Leu Thr Asn  Thr Met Gly Gly Tyr  Lys Glu Ser 

    1265                 1270                 1275             





Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 

    1280                 1285                 1290             





Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 

    1295                 1300                 1305             





Thr Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 

    1310                 1315                 1320             





Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 

    1325                 1330                 1335             





Leu Val  Ala Lys Tyr Asn Thr  Ser Asn Gly Ala Pro  Lys Asp Phe 

    1340                 1345                 1350             





Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Thr Thr Tyr 

    1355                 1360                 1365             





Pro Glu  Ser Thr Val Gly Thr  Leu Met Ser Lys Leu  Arg Glu Leu 

    1370                 1375                 1380             





Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 

    1385                 1390                 1395             





Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 

    1400                 1405                 1410             





Ser Cys  Asn Ser Gly Thr Ser  Tyr Asn Ser Ile Ser  Ser Val Val 

    1415                 1420                 1425             





Ser Arg  Arg Asn Ser His Val  Trp Asn Pro Thr Val  

    1430                 1435                 1440 





<210>  217

<211>  1364

<212>  PRT

<213>  Homo sapiens



<400>  217



Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 

1               5                   10                  15      





Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 

            20                  25                  30          





Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 

        35                  40                  45              





Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 

    50                  55                  60                  





Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 

65                  70                  75                  80  





Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 

                85                  90                  95      





Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 

            100                 105                 110         





Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 

        115                 120                 125             





Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 

    130                 135                 140                 





Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 

145                 150                 155                 160 





Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 

                165                 170                 175     





Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 

            180                 185                 190         





Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 

        195                 200                 205             





Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 

    210                 215                 220                 





Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 

225                 230                 235                 240 





Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 

                245                 250                 255     





Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 

            260                 265                 270         





Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 

        275                 280                 285             





Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 

    290                 295                 300                 





Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 

305                 310                 315                 320 





Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 

                325                 330                 335     





Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 

            340                 345                 350         





Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 

        355                 360                 365             





Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 

    370                 375                 380                 





Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 

385                 390                 395                 400 





Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 

                405                 410                 415     





Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 

            420                 425                 430         





Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 

        435                 440                 445             





Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 

    450                 455                 460                 





Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 

465                 470                 475                 480 





Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 

                485                 490                 495     





Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 

            500                 505                 510         





Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 

        515                 520                 525             





Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 

    530                 535                 540                 





His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 

545                 550                 555                 560 





Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 

                565                 570                 575     





Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 

            580                 585                 590         





Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 

        595                 600                 605             





Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 

    610                 615                 620                 





Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 

625                 630                 635                 640 





Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 

                645                 650                 655     





His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 

            660                 665                 670         





Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 

        675                 680                 685             





Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 

    690                 695                 700                 





Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 

705                 710                 715                 720 





Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 

                725                 730                 735     





Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 

            740                 745                 750         





Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 

        755                 760                 765             





Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 

    770                 775                 780                 





His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 

785                 790                 795                 800 





Ala Tyr Leu Asn Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu Gln Val 

                805                 810                 815     





Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg Pro Ala 

            820                 825                 830         





Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys Glu Ile 

        835                 840                 845             





Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu Phe Val 

    850                 855                 860                 





Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu Arg Asn 

865                 870                 875                 880 





His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro Pro Met 

                885                 890                 895     





Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp Arg Lys 

            900                 905                 910         





Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val Tyr Asp 

        915                 920                 925             





Val Gln Asp Gln Leu Asn Pro Leu Ala Ser Glu Glu Asp Leu Arg Arg 

    930                 935                 940                 





Ile Ala Gln Gln Leu His Ser Thr Gly Glu Ile Asn Ile Met Gln Ser 

945                 950                 955                 960 





Glu Thr Val Gln Asp Val Leu Leu Leu Asp Pro Arg Trp Leu Cys Thr 

                965                 970                 975     





Asn Val Leu Gly Lys Leu Leu Ser Val Glu Thr Pro Arg Ala Leu His 

            980                 985                 990         





His Tyr Arg Gly Arg Tyr Thr Val  Glu Asp Ile Gln Arg  Leu Val Pro 

        995                 1000                 1005             





Asp Ser  Asp Val Glu Glu Leu  Leu Gln Ile Leu Asp  Ala Met Asp 

    1010                 1015                 1020             





Ile Cys  Ala Arg Asp Leu Ser  Ser Gly Thr Met Val  Asp Val Pro 

    1025                 1030                 1035             





Ala Leu  Ile Lys Thr Asp Asn  Leu His Arg Ser Trp  Ala Asp Glu 

    1040                 1045                 1050             





Glu Asp  Glu Val Met Val Tyr  Gly Gly Val Arg Ile  Val Pro Val 

    1055                 1060                 1065             





Glu His  Leu Thr Pro Phe Pro  Cys Gly Ile Phe His  Lys Val Gln 

    1070                 1075                 1080             





Val Asn  Leu Cys Arg Trp Ile  His Gln Gln Ser Thr  Glu Gly Asp 

    1085                 1090                 1095             





Ala Asp  Ile Arg Leu Trp Val  Asn Gly Cys Lys Leu  Ala Asn Arg 

    1100                 1105                 1110             





Gly Ala  Glu Leu Leu Val Leu  Leu Val Asn His Gly  Gln Gly Ile 

    1115                 1120                 1125             





Glu Val  Gln Val Arg Gly Leu  Glu Thr Glu Lys Ile  Lys Cys Cys 

    1130                 1135                 1140             





Leu Leu  Leu Asp Ser Val Cys  Ser Thr Ile Glu Asn  Val Met Ala 

    1145                 1150                 1155             





Thr Thr  Leu Pro Gly Leu Leu  Thr Val Lys His Tyr  Leu Ser Pro 

    1160                 1165                 1170             





Gln Gln  Leu Arg Glu His His  Glu Pro Val Met Ile  Tyr Gln Pro 

    1175                 1180                 1185             





Arg Asp  Phe Phe Arg Ala Gln  Thr Leu Lys Glu Thr  Ser Leu Thr 

    1190                 1195                 1200             





Asn Thr  Met Gly Gly Tyr Lys  Glu Ser Phe Ser Ser  Ile Met Cys 

    1205                 1210                 1215             





Phe Gly  Cys His Asp Val Tyr  Ser Gln Ala Ser Leu  Gly Met Asp 

    1220                 1225                 1230             





Ile His  Ala Ser Asp Leu Asn  Leu Leu Thr Arg Arg  Lys Leu Ser 

    1235                 1240                 1245             





Arg Leu  Leu Asp Pro Pro Asp  Pro Leu Gly Lys Asp  Trp Cys Leu 

    1250                 1255                 1260             





Leu Ala  Met Asn Leu Gly Leu  Pro Asp Leu Val Ala  Lys Tyr Asn 

    1265                 1270                 1275             





Thr Ser  Asn Gly Ala Pro Lys  Asp Phe Leu Pro Ser  Pro Leu His 

    1280                 1285                 1290             





Ala Leu  Leu Arg Glu Trp Thr  Thr Tyr Pro Glu Ser  Thr Val Gly 

    1295                 1300                 1305             





Thr Leu  Met Ser Lys Leu Arg  Glu Leu Gly Arg Arg  Asp Ala Ala 

    1310                 1315                 1320             





Asp Phe  Leu Leu Lys Ala Ser  Ser Val Phe Lys Ile  Asn Leu Asp 

    1325                 1330                 1335             





Gly Asn  Gly Gln Glu Ala Tyr  Ala Ser Ser Cys Asn  Ser Gly Thr 

    1340                 1345                 1350             





Ser Tyr  Asn Ser Ile Ser Ser  Val Val Ser Arg 

    1355                 1360                 





<210>  218

<211>  427

<212>  PRT

<213>  Homo sapiens



<400>  218



Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 

1               5                   10                  15      





Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 

            20                  25                  30          





His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 

        35                  40                  45              





Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 

    50                  55                  60                  





Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 

65                  70                  75                  80  





Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 

                85                  90                  95      





Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 

            100                 105                 110         





Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 

        115                 120                 125             





Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 

    130                 135                 140                 





Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 

145                 150                 155                 160 





Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 

                165                 170                 175     





Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 

            180                 185                 190         





Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 

        195                 200                 205             





Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 

    210                 215                 220                 





Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 

225                 230                 235                 240 





Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 

                245                 250                 255     





Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 

            260                 265                 270         





Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 

        275                 280                 285             





Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 

    290                 295                 300                 





Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 

305                 310                 315                 320 





Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 

                325                 330                 335     





Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 

            340                 345                 350         





Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 

        355                 360                 365             





Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 

    370                 375                 380                 





Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 

385                 390                 395                 400 





Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn 

                405                 410                 415     





Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 

            420                 425         





<210>  219

<211>  161

<212>  PRT

<213>  Homo sapiens



<400>  219



Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 

1               5                   10                  15      





Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 

            20                  25                  30          





His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 

        35                  40                  45              





Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 

    50                  55                  60                  





Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 

65                  70                  75                  80  





Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 

                85                  90                  95      





Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 

            100                 105                 110         





Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 

        115                 120                 125             





Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Val Gln Ser Ser 

    130                 135                 140                 





Cys Leu Leu Glu Ser Cys Ser Gly Asn Trp Asp Ser Phe Gly Asn Cys 

145                 150                 155                 160 





His 

    





<210>  220

<211>  187

<212>  PRT

<213>  Homo sapiens



<400>  220



Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 

1               5                   10                  15      





Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 

            20                  25                  30          





His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 

        35                  40                  45              





Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 

    50                  55                  60                  





Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 

65                  70                  75                  80  





Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 

                85                  90                  95      





Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 

            100                 105                 110         





Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 

        115                 120                 125             





Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 

    130                 135                 140                 





Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 

145                 150                 155                 160 





Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 

                165                 170                 175     





Cys Ala Leu Ser Val Asp Ser Ser Thr Lys Met 

            180                 185         





<210>  221

<211>  318

<212>  PRT

<213>  Homo sapiens



<400>  221



Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 

1               5                   10                  15      





Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 

            20                  25                  30          





His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 

        35                  40                  45              





Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 

    50                  55                  60                  





Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 

65                  70                  75                  80  





Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 

                85                  90                  95      





Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 

            100                 105                 110         





Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 

        115                 120                 125             





Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Phe Tyr Gln Asp 

    130                 135                 140                 





Val Lys Asp Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val 

145                 150                 155                 160 





Cys Thr Ala Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg 

                165                 170                 175     





Arg Asn Gly Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg 

            180                 185                 190         





Arg Glu Val Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu 

        195                 200                 205             





Cys Trp Phe Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr 

    210                 215                 220                 





Asn Glu Met Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu 

225                 230                 235                 240 





Met Asp Tyr Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn 

                245                 250                 255     





Pro Ile Ala Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln 

            260                 265                 270         





Ser Cys Leu Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser 

        275                 280                 285             





Val Pro Met Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn 

    290                 295                 300                 





Asn His Asn Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 

305                 310                 315             





<210>  222

<211>  202

<212>  PRT

<213>  Homo sapiens



<400>  222



Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met Leu 

1               5                   10                  15      





Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp Trp 

            20                  25                  30          





Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala Ile 

        35                  40                  45              





Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly Ser 

    50                  55                  60                  





Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val Ala 

65                  70                  75                  80  





Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe Pro 

                85                  90                  95      





Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met Asp 

            100                 105                 110         





Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr Ile 

        115                 120                 125             





Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala Leu 

    130                 135                 140                 





Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu Cys 

145                 150                 155                 160 





Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met Asn 

                165                 170                 175     





Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn Thr 

            180                 185                 190         





Asp Arg Ser Ser His Lys Asp Ser Met Asn 

        195                 200         





<210>  223

<211>  814

<212>  PRT

<213>  Homo sapiens



<400>  223



Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg 

1               5                   10                  15      





Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu 

            20                  25                  30          





Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr 

        35                  40                  45              





Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Ser 

    50                  55                  60                  





Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro 

65                  70                  75                  80  





Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His 

                85                  90                  95      





Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala 

            100                 105                 110         





Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala 

        115                 120                 125             





Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu 

    130                 135                 140                 





Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val 

145                 150                 155                 160 





Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg 

                165                 170                 175     





Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile Val Val Asp Asn Val 

            180                 185                 190         





Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His 

        195                 200                 205             





Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu 

    210                 215                 220                 





Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro 

225                 230                 235                 240 





Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp 

                245                 250                 255     





Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr 

            260                 265                 270         





Met Thr Ile Ser Asp Glu Trp Asp Ile Pro Glu Lys Gln Pro Phe Lys 

        275                 280                 285             





Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp 

    290                 295                 300                 





Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp 

305                 310                 315                 320 





Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr 

                325                 330                 335     





Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe 

            340                 345                 350         





His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile 

        355                 360                 365             





Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys 

    370                 375                 380                 





Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp 

385                 390                 395                 400 





Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg 

                405                 410                 415     





Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser 

            420                 425                 430         





His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile 

        435                 440                 445             





Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile 

    450                 455                 460                 





Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala 

465                 470                 475                 480 





Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met 

                485                 490                 495     





Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val 

            500                 505                 510         





Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val 

        515                 520                 525             





Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe 

    530                 535                 540                 





Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu 

545                 550                 555                 560 





Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys 

                565                 570                 575     





Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr 

            580                 585                 590         





His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys 

        595                 600                 605             





Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val 

    610                 615                 620                 





Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr 

625                 630                 635                 640 





Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp 

                645                 650                 655     





Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp 

            660                 665                 670         





Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly 

        675                 680                 685             





Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp 

    690                 695                 700                 





Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile 

705                 710                 715                 720 





Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg 

                725                 730                 735     





Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr 

            740                 745                 750         





Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr 

        755                 760                 765             





Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr 

    770                 775                 780                 





Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu 

785                 790                 795                 800 





Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Asn Gln Glu 

                805                 810                 





<210>  224

<211>  873

<212>  PRT

<213>  Homo sapiens



<400>  224



Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg 

1               5                   10                  15      





Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu 

            20                  25                  30          





Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr 

        35                  40                  45              





Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Ser 

    50                  55                  60                  





Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro 

65                  70                  75                  80  





Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His 

                85                  90                  95      





Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala 

            100                 105                 110         





Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala 

        115                 120                 125             





Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu 

    130                 135                 140                 





Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val 

145                 150                 155                 160 





Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg 

                165                 170                 175     





Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile Val Val Asp Asn Val 

            180                 185                 190         





Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His 

        195                 200                 205             





Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu 

    210                 215                 220                 





Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro 

225                 230                 235                 240 





Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp 

                245                 250                 255     





Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr 

            260                 265                 270         





Met Thr Ile Ser Asp Glu Trp Asp Ile Pro Glu Lys Gln Pro Phe Lys 

        275                 280                 285             





Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp 

    290                 295                 300                 





Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp 

305                 310                 315                 320 





Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr 

                325                 330                 335     





Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe 

            340                 345                 350         





His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile 

        355                 360                 365             





Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys 

    370                 375                 380                 





Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp 

385                 390                 395                 400 





Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg 

                405                 410                 415     





Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser 

            420                 425                 430         





His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile 

        435                 440                 445             





Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile 

    450                 455                 460                 





Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala 

465                 470                 475                 480 





Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met 

                485                 490                 495     





Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val 

            500                 505                 510         





Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val 

        515                 520                 525             





Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe 

    530                 535                 540                 





Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu 

545                 550                 555                 560 





Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys 

                565                 570                 575     





Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr 

            580                 585                 590         





His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys 

        595                 600                 605             





Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val 

    610                 615                 620                 





Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr 

625                 630                 635                 640 





Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp 

                645                 650                 655     





Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp 

            660                 665                 670         





Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly 

        675                 680                 685             





Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp 

    690                 695                 700                 





Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile 

705                 710                 715                 720 





Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg 

                725                 730                 735     





Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr 

            740                 745                 750         





Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr 

        755                 760                 765             





Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr 

    770                 775                 780                 





Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu 

785                 790                 795                 800 





Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Ile Arg Ser Asp Leu 

                805                 810                 815     





Glu His Cys Ala Gln Pro Cys Val Leu Trp Ser Arg Gly Arg Pro Ala 

            820                 825                 830         





Gly Ser Arg Val Thr Pro Ala Ser Ser Leu Cys Ser Leu Ala Leu Asp 

        835                 840                 845             





Cys Asp Cys Ala Trp Ile Leu Pro Leu Arg His Ile Phe Val Pro Phe 

    850                 855                 860                 





Ser Pro Trp Cys Leu Gln Trp Gly Ile 

865                 870             





<210>  225

<211>  134

<212>  PRT

<213>  Homo sapiens



<400>  225



Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 

1               5                   10                  15      





Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 

            20                  25                  30          





Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 

        35                  40                  45              





Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Ser Lys Met Glu Ile 

    50                  55                  60                  





Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 

65                  70                  75                  80  





Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 

                85                  90                  95      





Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 

            100                 105                 110         





Leu Ser Leu Gln Ala Ser Glu Phe Pro Ser Glu Leu Met Ser Asn Asp 

        115                 120                 125             





Ser Lys Ala Leu Cys Gly 

    130                 





<210>  226

<211>  664

<212>  PRT

<213>  Homo sapiens



<400>  226



Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 

1               5                   10                  15      





Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 

            20                  25                  30          





Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 

        35                  40                  45              





Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 

    50                  55                  60                  





Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 

65                  70                  75                  80  





Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 

                85                  90                  95      





Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 

            100                 105                 110         





Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 

        115                 120                 125             





Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 

    130                 135                 140                 





Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 

145                 150                 155                 160 





Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 

                165                 170                 175     





Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 

            180                 185                 190         





Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 

        195                 200                 205             





Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 

    210                 215                 220                 





Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 

225                 230                 235                 240 





Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 

                245                 250                 255     





Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 

            260                 265                 270         





Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 

        275                 280                 285             





His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 

    290                 295                 300                 





Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 

305                 310                 315                 320 





Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 

                325                 330                 335     





Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 

            340                 345                 350         





Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 

        355                 360                 365             





Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 

    370                 375                 380                 





Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 

385                 390                 395                 400 





Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 

                405                 410                 415     





Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 

            420                 425                 430         





His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 

        435                 440                 445             





Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 

    450                 455                 460                 





Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 

465                 470                 475                 480 





Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 

                485                 490                 495     





Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 

            500                 505                 510         





Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 

        515                 520                 525             





Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 

    530                 535                 540                 





Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 

545                 550                 555                 560 





Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 

                565                 570                 575     





Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 

            580                 585                 590         





Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 

        595                 600                 605             





Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 

    610                 615                 620                 





Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 

625                 630                 635                 640 





Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 

                645                 650                 655     





Ser Pro Gln Asn Cys Ser Ile Met 

            660                 





<210>  227

<211>  572

<212>  PRT

<213>  Homo sapiens



<400>  227



Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 

1               5                   10                  15      





Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 

            20                  25                  30          





Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 

        35                  40                  45              





Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 

    50                  55                  60                  





Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 

65                  70                  75                  80  





Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 

                85                  90                  95      





Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 

            100                 105                 110         





Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 

        115                 120                 125             





Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 

    130                 135                 140                 





Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 

145                 150                 155                 160 





Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 

                165                 170                 175     





Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 

            180                 185                 190         





Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 

        195                 200                 205             





Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 

    210                 215                 220                 





Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 

225                 230                 235                 240 





Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 

                245                 250                 255     





Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 

            260                 265                 270         





Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 

        275                 280                 285             





His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 

    290                 295                 300                 





Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 

305                 310                 315                 320 





Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 

                325                 330                 335     





Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 

            340                 345                 350         





Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 

        355                 360                 365             





Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 

    370                 375                 380                 





Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 

385                 390                 395                 400 





Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 

                405                 410                 415     





Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 

            420                 425                 430         





His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 

        435                 440                 445             





Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 

    450                 455                 460                 





Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 

465                 470                 475                 480 





Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 

                485                 490                 495     





Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 

            500                 505                 510         





Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 

        515                 520                 525             





Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 

    530                 535                 540                 





Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 

545                 550                 555                 560 





Leu Leu His His His His Val Ser Gly Ser Arg Arg 

                565                 570         





<210>  228

<211>  634

<212>  PRT

<213>  Homo sapiens



<400>  228



Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 

1               5                   10                  15      





Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 

            20                  25                  30          





Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 

        35                  40                  45              





Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 

    50                  55                  60                  





Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 

65                  70                  75                  80  





Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 

                85                  90                  95      





Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 

            100                 105                 110         





Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 

        115                 120                 125             





Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 

    130                 135                 140                 





Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 

145                 150                 155                 160 





Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 

                165                 170                 175     





Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 

            180                 185                 190         





Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 

        195                 200                 205             





Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 

    210                 215                 220                 





Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 

225                 230                 235                 240 





Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 

                245                 250                 255     





Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 

            260                 265                 270         





Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 

        275                 280                 285             





His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 

    290                 295                 300                 





Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 

305                 310                 315                 320 





Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 

                325                 330                 335     





Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 

            340                 345                 350         





Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 

        355                 360                 365             





Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 

    370                 375                 380                 





Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 

385                 390                 395                 400 





Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 

                405                 410                 415     





Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 

            420                 425                 430         





His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 

        435                 440                 445             





Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 

    450                 455                 460                 





Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 

465                 470                 475                 480 





Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 

                485                 490                 495     





Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 

            500                 505                 510         





Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 

        515                 520                 525             





Ala Leu Ile Asn Ser Thr Gly Glu Gly Ser His Cys Ser Ser Ser Gly 

    530                 535                 540                 





Asp Pro Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr 

545                 550                 555                 560 





Cys Gly Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln 

                565                 570                 575     





Val Gly Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val 

            580                 585                 590         





Thr Arg Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly 

        595                 600                 605             





Asp Asn Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg 

    610                 615                 620                 





Thr Gln Ser Pro Gln Asn Cys Ser Ile Met 

625                 630                 





<210>  229

<211>  574

<212>  PRT

<213>  Homo sapiens



<400>  229



Met Gly Asn Ser Glu Gly Cys Asn Thr Lys Lys Glu Gly Asp Leu Ile 

1               5                   10                  15      





Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 

            20                  25                  30          





Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 

        35                  40                  45              





Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 

    50                  55                  60                  





Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 

65                  70                  75                  80  





Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 

                85                  90                  95      





Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 

            100                 105                 110         





Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 

        115                 120                 125             





Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 

    130                 135                 140                 





Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 

145                 150                 155                 160 





Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 

                165                 170                 175     





His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 

            180                 185                 190         





Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 

        195                 200                 205             





Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 

    210                 215                 220                 





Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 

225                 230                 235                 240 





Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 

                245                 250                 255     





Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 

            260                 265                 270         





Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 

        275                 280                 285             





Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 

    290                 295                 300                 





Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 

305                 310                 315                 320 





His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 

                325                 330                 335     





Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 

            340                 345                 350         





Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 

        355                 360                 365             





Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 

    370                 375                 380                 





Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 

385                 390                 395                 400 





Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 

                405                 410                 415     





Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 

            420                 425                 430         





Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 

        435                 440                 445             





Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 

    450                 455                 460                 





Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 

465                 470                 475                 480 





Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly 

                485                 490                 495     





Gly Pro Ile Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg 

            500                 505                 510         





Ser Tyr Arg Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn 

        515                 520                 525             





Leu Val Thr Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln 

    530                 535                 540                 





Ser Pro Gln Asn Cys Ser Ile Ile Gln Glu Met Gly Met Arg Trp Glu 

545                 550                 555                 560 





Val Glu Glu Gly Arg Arg Lys Val Ser Leu Ser Cys Leu Pro 

                565                 570                 





<210>  230

<211>  565

<212>  PRT

<213>  Homo sapiens



<400>  230



Met Asp Leu Glu Ala Trp Asp Pro His Leu Glu Pro Asp Ala Glu Ala 

1               5                   10                  15      





Met Val Asp Gly Asn Thr Lys Lys Glu Gly Asp Leu Ile Ala Ala Gln 

            20                  25                  30          





Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys Glu Ala Ala 

        35                  40                  45              





Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly Glu Leu His 

    50                  55                  60                  





Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu Gly Glu Ala 

65                  70                  75                  80  





Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp Ala Glu Asn 

                85                  90                  95      





Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys Asn Ile Tyr 

            100                 105                 110         





Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr Arg Leu Val 

        115                 120                 125             





Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg Leu Ala Asp 

    130                 135                 140                 





Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val Glu Gln Tyr 

145                 150                 155                 160 





Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp Asn Ala Arg 

                165                 170                 175     





Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala His Glu Glu 

            180                 185                 190         





Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala Gln Leu Ser 

        195                 200                 205             





Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu Arg Asp Leu 

    210                 215                 220                 





Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg Leu Leu Ala 

225                 230                 235                 240 





Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met Gln Gln Gln 

                245                 250                 255     





Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala Leu Asp Met 

            260                 265                 270         





Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu Arg Leu 

        275                 280                 285             





Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly Arg Ala Ser 

    290                 295                 300                 





Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr Lys Lys Arg 

305                 310                 315                 320 





Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln His Ala Arg 

                325                 330                 335     





Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu Gly Lys Phe 

            340                 345                 350         





Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met Gly Asn Trp 

        355                 360                 365             





Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr Tyr Arg Phe 

    370                 375                 380                 





Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr Ile Trp Ala 

385                 390                 395                 400 





Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu Val Trp Lys 

                405                 410                 415     





Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr Ala Leu Ile 

            420                 425                 430         





Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val Arg Ser Val 

        435                 440                 445             





Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp Leu Leu His 

    450                 455                 460                 





His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro Ala Glu Tyr 

465                 470                 475                 480 





Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly Gln Pro Ala 

                485                 490                 495     





Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly Gly Pro Ile 

            500                 505                 510         





Ser Ser Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg Ser Tyr Arg 

        515                 520                 525             





Ser Val Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn Leu Val Thr 

    530                 535                 540                 





Arg Ser Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln Ser Pro Gln 

545                 550                 555                 560 





Asn Cys Ser Ile Met 

                565 





<210>  231

<211>  614

<212>  PRT

<213>  Homo sapiens



<400>  231



Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 

1               5                   10                  15      





Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 

            20                  25                  30          





Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 

        35                  40                  45              





Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 

    50                  55                  60                  





Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 

65                  70                  75                  80  





Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 

                85                  90                  95      





Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 

            100                 105                 110         





Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 

        115                 120                 125             





Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 

    130                 135                 140                 





Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 

145                 150                 155                 160 





Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 

                165                 170                 175     





Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 

            180                 185                 190         





Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 

        195                 200                 205             





Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 

    210                 215                 220                 





Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 

225                 230                 235                 240 





Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 

                245                 250                 255     





Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 

            260                 265                 270         





Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 

        275                 280                 285             





His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 

    290                 295                 300                 





Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 

305                 310                 315                 320 





Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 

                325                 330                 335     





Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 

            340                 345                 350         





Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 

        355                 360                 365             





Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 

    370                 375                 380                 





Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 

385                 390                 395                 400 





Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 

                405                 410                 415     





Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 

            420                 425                 430         





His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 

        435                 440                 445             





Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 

    450                 455                 460                 





Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 

465                 470                 475                 480 





Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 

                485                 490                 495     





Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 

            500                 505                 510         





Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 

        515                 520                 525             





Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 

    530                 535                 540                 





Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 

545                 550                 555                 560 





Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 

                565                 570                 575     





Ala Glu Tyr Asn Leu Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly 

            580                 585                 590         





Gln Pro Ala Asp Lys Ala Ser Ala Ser Gly Ser Gly Ala Gln Ser Pro 

        595                 600                 605             





Gln Asn Cys Ser Ile Met 

    610                 





<210>  232

<211>  2225

<212>  PRT

<213>  Homo sapiens



<400>  232



Met Ala Ala Leu Val Leu Glu Asp Gly Ser Val Leu Arg Gly Gln Pro 

1               5                   10                  15      





Phe Gly Ala Ala Val Ser Thr Ala Gly Glu Val Val Phe Gln Thr Gly 

            20                  25                  30          





Met Val Gly Tyr Pro Glu Ala Leu Thr Asp Pro Ser Tyr Lys Ala Gln 

        35                  40                  45              





Ile Leu Val Leu Thr Tyr Pro Leu Ile Gly Asn Tyr Gly Ile Pro Pro 

    50                  55                  60                  





Asp Glu Met Asp Glu Phe Gly Leu Cys Lys Trp Phe Glu Ser Ser Gly 

65                  70                  75                  80  





Ile His Val Ala Ala Leu Val Val Gly Glu Cys Cys Pro Thr Pro Ser 

                85                  90                  95      





His Trp Ser Ala Thr Arg Thr Leu His Glu Trp Leu Gln Gln His Gly 

            100                 105                 110         





Ile Pro Gly Leu Gln Gly Val Asp Thr Arg Glu Leu Thr Lys Lys Leu 

        115                 120                 125             





Arg Glu Gln Gly Ser Leu Leu Gly Lys Leu Val Gln Asn Gly Thr Glu 

    130                 135                 140                 





Pro Ser Ser Leu Pro Phe Leu Asp Pro Asn Ala Arg Pro Leu Val Pro 

145                 150                 155                 160 





Glu Val Ser Ile Lys Thr Pro Arg Val Phe Asn Thr Gly Gly Ala Pro 

                165                 170                 175     





Arg Ile Leu Ala Leu Asp Cys Gly Leu Lys Tyr Asn Gln Ile Arg Cys 

            180                 185                 190         





Leu Cys Gln Arg Gly Ala Glu Val Thr Val Val Pro Trp Asp His Ala 

        195                 200                 205             





Leu Asp Ser Gln Glu Tyr Glu Gly Leu Phe Leu Ser Asn Gly Pro Gly 

    210                 215                 220                 





Asp Pro Ala Ser Tyr Pro Ser Val Val Ser Thr Leu Ser Arg Val Leu 

225                 230                 235                 240 





Ser Glu Pro Asn Pro Arg Pro Val Phe Gly Ile Cys Leu Gly His Gln 

                245                 250                 255     





Leu Leu Ala Leu Ala Ile Gly Ala Lys Thr Tyr Lys Met Arg Tyr Gly 

            260                 265                 270         





Asn Arg Gly His Asn Gln Pro Cys Leu Leu Val Gly Ser Gly Arg Cys 

        275                 280                 285             





Phe Leu Thr Ser Gln Asn His Gly Phe Ala Val Glu Thr Asp Ser Leu 

    290                 295                 300                 





Pro Ala Asp Trp Ala Pro Leu Phe Thr Asn Ala Asn Asp Gly Ser Asn 

305                 310                 315                 320 





Glu Gly Ile Val His Asn Ser Leu Pro Phe Phe Ser Val Gln Phe His 

                325                 330                 335     





Pro Glu His Gln Ala Gly Pro Ser Asp Met Glu Leu Leu Phe Asp Ile 

            340                 345                 350         





Phe Leu Glu Thr Val Lys Glu Ala Thr Ala Gly Asn Pro Gly Gly Gln 

        355                 360                 365             





Thr Val Arg Glu Arg Leu Thr Glu Arg Leu Cys Pro Pro Gly Ile Pro 

    370                 375                 380                 





Thr Pro Gly Ser Gly Leu Pro Pro Pro Arg Lys Val Leu Ile Leu Gly 

385                 390                 395                 400 





Ser Gly Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly 

                405                 410                 415     





Ser Gln Ala Ile Lys Ala Leu Lys Glu Glu Asn Ile Gln Thr Leu Leu 

            420                 425                 430         





Ile Asn Pro Asn Ile Ala Thr Val Gln Thr Ser Gln Gly Leu Ala Asp 

        435                 440                 445             





Lys Val Tyr Phe Leu Pro Ile Thr Pro His Tyr Val Thr Gln Val Ile 

    450                 455                 460                 





Arg Asn Glu Arg Pro Asp Gly Val Leu Leu Thr Phe Gly Gly Gln Thr 

465                 470                 475                 480 





Ala Leu Asn Cys Gly Val Glu Leu Thr Lys Ala Gly Val Leu Ala Arg 

                485                 490                 495     





Tyr Gly Val Arg Val Leu Gly Thr Pro Val Glu Thr Ile Glu Leu Thr 

            500                 505                 510         





Glu Asp Arg Arg Ala Phe Ala Ala Arg Met Ala Glu Ile Gly Glu His 

        515                 520                 525             





Val Ala Pro Ser Glu Ala Ala Asn Ser Leu Glu Gln Ala Gln Ala Ala 

    530                 535                 540                 





Ala Glu Arg Leu Gly Tyr Pro Val Leu Val Arg Ala Ala Phe Ala Leu 

545                 550                 555                 560 





Gly Gly Leu Gly Ser Gly Phe Ala Ser Asn Arg Glu Glu Leu Ser Ala 

                565                 570                 575     





Leu Val Ala Pro Ala Phe Ala His Thr Ser Gln Val Leu Val Asp Lys 

            580                 585                 590         





Ser Leu Lys Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 

        595                 600                 605             





Tyr Gly Asn Cys Val Thr Val Cys Asn Met Glu Asn Leu Asp Pro Leu 

    610                 615                 620                 





Gly Ile His Thr Gly Glu Ser Ile Val Val Ala Pro Ser Gln Thr Leu 

625                 630                 635                 640 





Asn Asp Arg Glu Tyr Gln Leu Leu Arg Gln Thr Ala Ile Lys Val Thr 

                645                 650                 655     





Gln His Leu Gly Ile Val Gly Glu Cys Asn Val Gln Tyr Ala Leu Asn 

            660                 665                 670         





Pro Glu Ser Glu Gln Tyr Tyr Ile Ile Glu Val Asn Ala Arg Leu Ser 

        675                 680                 685             





Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Tyr 

    690                 695                 700                 





Val Ala Ala Lys Leu Ala Leu Gly Ile Pro Leu Pro Glu Leu Arg Asn 

705                 710                 715                 720 





Ser Val Thr Gly Gly Thr Ala Ala Phe Glu Pro Ser Val Asp Tyr Cys 

                725                 730                 735     





Val Val Lys Ile Pro Arg Trp Asp Leu Ser Lys Phe Leu Arg Val Ser 

            740                 745                 750         





Thr Lys Ile Gly Ser Cys Met Lys Ser Val Gly Glu Val Met Gly Ile 

        755                 760                 765             





Gly Arg Ser Phe Glu Glu Ala Phe Gln Lys Ala Leu Arg Met Val Asp 

    770                 775                 780                 





Glu Asn Cys Val Gly Phe Asp His Thr Val Lys Pro Val Ser Asp Met 

785                 790                 795                 800 





Glu Leu Glu Thr Pro Thr Asp Lys Arg Ile Phe Val Val Ala Ala Ala 

                805                 810                 815     





Leu Trp Ala Gly Tyr Ser Val Asp Arg Leu Tyr Glu Leu Thr Arg Ile 

            820                 825                 830         





Asp Arg Trp Phe Leu His Arg Met Lys Arg Ile Ile Ala His Ala Gln 

        835                 840                 845             





Leu Leu Glu Gln His Arg Gly Gln Pro Leu Pro Pro Asp Leu Leu Gln 

    850                 855                 860                 





Gln Ala Lys Cys Leu Gly Phe Ser Asp Lys Gln Ile Ala Leu Ala Val 

865                 870                 875                 880 





Leu Ser Thr Glu Leu Ala Val Arg Lys Leu Arg Gln Glu Leu Gly Ile 

                885                 890                 895     





Cys Pro Ala Val Lys Gln Ile Asp Thr Val Ala Ala Glu Trp Pro Ala 

            900                 905                 910         





Gln Thr Asn Tyr Leu Tyr Leu Thr Tyr Trp Gly Thr Thr His Asp Leu 

        915                 920                 925             





Thr Phe Arg Thr Pro His Val Leu Val Leu Gly Ser Gly Val Tyr Arg 

    930                 935                 940                 





Ile Gly Ser Ser Val Glu Phe Asp Trp Cys Ala Val Gly Cys Ile Gln 

945                 950                 955                 960 





Gln Leu Arg Lys Met Gly Tyr Lys Thr Ile Met Val Asn Tyr Asn Pro 

                965                 970                 975     





Glu Thr Val Ser Thr Asp Tyr Asp Met Cys Asp Arg Leu Tyr Phe Asp 

            980                 985                 990         





Glu Ile Ser Phe Glu Val Val Met  Asp Ile Tyr Glu Leu  Glu Asn Pro 

        995                 1000                 1005             





Glu Gly  Val Ile Leu Ser Met  Gly Gly Gln Leu Pro  Asn Asn Met 

    1010                 1015                 1020             





Ala Met  Ala Leu His Arg Gln  Gln Cys Arg Val Leu  Gly Thr Ser 

    1025                 1030                 1035             





Pro Glu  Ala Ile Asp Ser Ala  Glu Asn Arg Phe Lys  Phe Ser Arg 

    1040                 1045                 1050             





Leu Leu  Asp Thr Ile Gly Ile  Ser Gln Pro Gln Trp  Arg Glu Leu 

    1055                 1060                 1065             





Ser Asp  Leu Glu Ser Ala Arg  Gln Phe Cys Gln Thr  Val Gly Tyr 

    1070                 1075                 1080             





Pro Cys  Val Val Arg Pro Ser  Tyr Val Leu Ser Gly  Ala Ala Met 

    1085                 1090                 1095             





Asn Val  Ala Tyr Thr Asp Gly  Asp Leu Glu Arg Phe  Leu Ser Ser 

    1100                 1105                 1110             





Ala Ala  Ala Val Ser Lys Glu  His Pro Val Val Ile  Ser Lys Phe 

    1115                 1120                 1125             





Ile Gln  Glu Ala Lys Glu Ile  Asp Val Asp Ala Val  Ala Ser Asp 

    1130                 1135                 1140             





Gly Val  Val Ala Ala Ile Ala  Ile Ser Glu His Val  Glu Asn Ala 

    1145                 1150                 1155             





Gly Val  His Ser Gly Asp Ala  Thr Leu Val Thr Pro  Pro Gln Asp 

    1160                 1165                 1170             





Ile Thr  Ala Lys Thr Leu Glu  Arg Ile Lys Ala Ile  Val His Ala 

    1175                 1180                 1185             





Val Gly  Gln Glu Leu Gln Val  Thr Gly Pro Phe Asn  Leu Gln Leu 

    1190                 1195                 1200             





Ile Ala  Lys Asp Asp Gln Leu  Lys Val Ile Glu Cys  Asn Val Arg 

    1205                 1210                 1215             





Val Ser  Arg Ser Phe Pro Phe  Val Ser Lys Thr Leu  Gly Val Asp 

    1220                 1225                 1230             





Leu Val  Ala Leu Ala Thr Arg  Val Ile Met Gly Glu  Glu Val Glu 

    1235                 1240                 1245             





Pro Val  Gly Leu Met Thr Gly  Ser Gly Val Val Gly  Val Lys Val 

    1250                 1255                 1260             





Pro Gln  Phe Ser Phe Ser Arg  Leu Ala Gly Ala Asp  Val Val Leu 

    1265                 1270                 1275             





Gly Val  Glu Met Thr Ser Thr  Gly Glu Val Ala Gly  Phe Gly Glu 

    1280                 1285                 1290             





Ser Arg  Cys Glu Ala Tyr Leu  Lys Ala Met Leu Ser  Thr Gly Phe 

    1295                 1300                 1305             





Lys Ile  Pro Lys Lys Asn Ile  Leu Leu Thr Ile Gly  Ser Tyr Lys 

    1310                 1315                 1320             





Asn Lys  Ser Glu Leu Leu Pro  Thr Val Arg Leu Leu  Glu Ser Leu 

    1325                 1330                 1335             





Gly Tyr  Ser Leu Tyr Ala Ser  Leu Gly Thr Ala Asp  Phe Tyr Thr 

    1340                 1345                 1350             





Glu His  Gly Val Lys Val Thr  Ala Val Asp Trp His  Phe Glu Glu 

    1355                 1360                 1365             





Ala Val  Asp Gly Glu Cys Pro  Pro Gln Arg Ser Ile  Leu Glu Gln 

    1370                 1375                 1380             





Leu Ala  Glu Lys Asn Phe Glu  Leu Val Ile Asn Leu  Ser Met Arg 

    1385                 1390                 1395             





Gly Ala  Gly Gly Arg Arg Leu  Ser Ser Phe Val Thr  Lys Gly Tyr 

    1400                 1405                 1410             





Arg Thr  Arg Arg Leu Ala Ala  Asp Phe Ser Val Pro  Leu Ile Ile 

    1415                 1420                 1425             





Asp Ile  Lys Cys Thr Lys Leu  Phe Val Glu Ala Leu  Gly Gln Ile 

    1430                 1435                 1440             





Gly Pro  Ala Pro Pro Leu Lys  Val His Val Asp Cys  Met Thr Ser 

    1445                 1450                 1455             





Gln Lys  Leu Val Arg Leu Pro  Gly Leu Ile Asp Val  His Val His 

    1460                 1465                 1470             





Leu Arg  Glu Pro Gly Gly Thr  His Lys Glu Asp Phe  Ala Ser Gly 

    1475                 1480                 1485             





Thr Ala  Ala Ala Leu Ala Gly  Gly Ile Thr Met Val  Cys Ala Met 

    1490                 1495                 1500             





Pro Asn  Thr Arg Pro Pro Ile  Ile Asp Ala Pro Ala  Leu Ala Leu 

    1505                 1510                 1515             





Ala Gln  Lys Leu Ala Glu Ala  Gly Ala Arg Cys Asp  Phe Ala Leu 

    1520                 1525                 1530             





Phe Leu  Gly Ala Ser Ser Glu  Asn Ala Gly Thr Leu  Gly Thr Val 

    1535                 1540                 1545             





Ala Gly  Ser Ala Ala Gly Leu  Lys Leu Tyr Leu Asn  Glu Thr Phe 

    1550                 1555                 1560             





Ser Glu  Leu Arg Leu Asp Ser  Val Val Gln Trp Met  Glu His Phe 

    1565                 1570                 1575             





Glu Thr  Trp Pro Ser His Leu  Pro Ile Val Ala His  Ala Glu Gln 

    1580                 1585                 1590             





Gln Thr  Val Ala Ala Val Leu  Met Val Ala Gln Leu  Thr Gln Arg 

    1595                 1600                 1605             





Ser Val  His Ile Cys His Val  Ala Arg Lys Glu Glu  Ile Leu Leu 

    1610                 1615                 1620             





Ile Lys  Ala Ala Lys Ala Arg  Gly Leu Pro Val Thr  Cys Glu Val 

    1625                 1630                 1635             





Ala Pro  His His Leu Phe Leu  Ser His Asp Asp Leu  Glu Arg Leu 

    1640                 1645                 1650             





Gly Pro  Gly Lys Gly Glu Val  Arg Pro Glu Leu Gly  Ser Arg Gln 

    1655                 1660                 1665             





Asp Val  Glu Ala Leu Trp Glu  Asn Met Ala Val Ile  Asp Cys Phe 

    1670                 1675                 1680             





Ala Ser  Asp His Ala Pro His  Thr Leu Glu Glu Lys  Cys Gly Ser 

    1685                 1690                 1695             





Arg Pro  Pro Pro Gly Phe Pro  Gly Leu Glu Thr Met  Leu Pro Leu 

    1700                 1705                 1710             





Leu Leu  Thr Ala Val Ser Glu  Gly Arg Leu Ser Leu  Asp Asp Leu 

    1715                 1720                 1725             





Leu Gln  Arg Leu His His Asn  Pro Arg Arg Ile Phe  His Leu Pro 

    1730                 1735                 1740             





Pro Gln  Glu Asp Thr Tyr Val  Glu Val Asp Leu Glu  His Glu Trp 

    1745                 1750                 1755             





Thr Ile  Pro Ser His Met Pro  Phe Ser Lys Ala His  Trp Thr Pro 

    1760                 1765                 1770             





Phe Glu  Gly Gln Lys Val Lys  Gly Thr Val Arg Arg  Val Val Leu 

    1775                 1780                 1785             





Arg Gly  Glu Val Ala Tyr Ile  Asp Gly Gln Val Leu  Val Pro Pro 

    1790                 1795                 1800             





Gly Tyr  Gly Gln Asp Val Arg  Lys Trp Pro Gln Gly  Ala Val Pro 

    1805                 1810                 1815             





Gln Leu  Pro Pro Ser Ala Pro  Ala Thr Ser Glu Met  Thr Thr Thr 

    1820                 1825                 1830             





Pro Glu  Arg Pro Arg Arg Gly  Ile Pro Gly Leu Pro  Asp Gly Arg 

    1835                 1840                 1845             





Phe His  Leu Pro Pro Arg Ile  His Arg Ala Ser Asp  Pro Gly Leu 

    1850                 1855                 1860             





Pro Ala  Glu Glu Pro Lys Glu  Lys Ser Ser Arg Lys  Val Ala Glu 

    1865                 1870                 1875             





Pro Glu  Leu Met Gly Thr Pro  Asp Gly Thr Cys Tyr  Pro Pro Pro 

    1880                 1885                 1890             





Pro Val  Pro Arg Gln Ala Ser  Pro Gln Asn Leu Gly  Thr Pro Gly 

    1895                 1900                 1905             





Leu Leu  His Pro Gln Thr Ser  Pro Leu Leu His Ser  Leu Val Gly 

    1910                 1915                 1920             





Gln His  Ile Leu Ser Val Gln  Gln Phe Thr Lys Asp  Gln Met Ser 

    1925                 1930                 1935             





His Leu  Phe Asn Val Ala His  Thr Leu Arg Met Met  Val Gln Lys 

    1940                 1945                 1950             





Glu Arg  Ser Leu Asp Ile Leu  Lys Gly Lys Val Met  Ala Ser Met 

    1955                 1960                 1965             





Phe Tyr  Glu Val Ser Thr Arg  Thr Ser Ser Ser Phe  Ala Ala Ala 

    1970                 1975                 1980             





Met Ala  Arg Leu Gly Gly Ala  Val Leu Ser Phe Ser  Glu Ala Thr 

    1985                 1990                 1995             





Ser Ser  Val Gln Lys Gly Glu  Ser Leu Ala Asp Ser  Val Gln Thr 

    2000                 2005                 2010             





Met Ser  Cys Tyr Ala Asp Val  Val Val Leu Arg His  Pro Gln Pro 

    2015                 2020                 2025             





Gly Ala  Val Glu Leu Ala Ala  Lys His Cys Arg Arg  Pro Val Ile 

    2030                 2035                 2040             





Asn Ala  Gly Asp Gly Val Gly  Glu His Pro Thr Gln  Ala Leu Leu 

    2045                 2050                 2055             





Asp Ile  Phe Thr Ile Arg Glu  Glu Leu Gly Thr Val  Asn Gly Met 

    2060                 2065                 2070             





Thr Ile  Thr Met Val Gly Asp  Leu Lys His Gly Arg  Thr Val His 

    2075                 2080                 2085             





Ser Leu  Ala Cys Leu Leu Thr  Gln Tyr Arg Val Ser  Leu Arg Tyr 

    2090                 2095                 2100             





Val Ala  Pro Pro Ser Leu Arg  Met Pro Pro Thr Val  Arg Ala Phe 

    2105                 2110                 2115             





Val Ala  Ser Arg Gly Thr Lys  Gln Glu Glu Phe Glu  Ser Ile Glu 

    2120                 2125                 2130             





Glu Ala  Leu Pro Asp Thr Asp  Val Leu Tyr Met Thr  Arg Ile Gln 

    2135                 2140                 2145             





Lys Glu  Arg Phe Gly Ser Thr  Gln Glu Tyr Glu Ala  Cys Phe Gly 

    2150                 2155                 2160             





Gln Phe  Ile Leu Thr Pro His  Ile Met Thr Arg Ala  Lys Lys Lys 

    2165                 2170                 2175             





Met Val  Val Met His Pro Met  Pro Arg Val Asn Glu  Ile Ser Val 

    2180                 2185                 2190             





Glu Val  Asp Ser Asp Pro Arg  Ala Ala Tyr Phe Arg  Gln Ala Glu 

    2195                 2200                 2205             





Asn Gly  Met Tyr Ile Arg Met  Ala Leu Leu Ala Thr  Val Leu Gly 

    2210                 2215                 2220             





Arg Phe  

    2225 





<210>  233

<211>  134

<212>  PRT

<213>  Homo sapiens



<400>  233



Met Gly Arg Ser Arg Arg Thr Gly Ala His Arg Ala His Ser Leu Ala 

1               5                   10                  15      





Arg Gln Met Lys Ala Lys Arg Arg Arg Pro Asp Leu Asp Glu Ile His 

            20                  25                  30          





Arg Glu Leu Arg Pro Gln Gly Ser Ala Arg Pro Gln Pro Asp Pro Asn 

        35                  40                  45              





Ala Glu Phe Asp Pro Asp Leu Pro Gly Gly Gly Leu His Arg Cys Leu 

    50                  55                  60                  





Ala Cys Ala Arg Tyr Phe Ile Asp Ser Thr Asn Leu Lys Thr His Phe 

65                  70                  75                  80  





Arg Ser Lys Asp His Lys Lys Arg Leu Lys Gln Leu Ser Val Glu Pro 

                85                  90                  95      





Tyr Ser Gln Glu Glu Ala Glu Arg Ala Ala Gly Met Gly Ser Tyr Val 

            100                 105                 110         





Pro Pro Arg Arg Leu Ala Val Pro Thr Glu Val Ser Thr Glu Val Pro 

        115                 120                 125             





Glu Met Asp Thr Ser Thr 

    130                 





<210>  234

<211>  367

<212>  PRT

<213>  Homo sapiens



<400>  234



Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 

1               5                   10                  15      





Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 

            20                  25                  30          





Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 

        35                  40                  45              





Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 

    50                  55                  60                  





Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 

65                  70                  75                  80  





Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 

                85                  90                  95      





Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 

            100                 105                 110         





Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 

        115                 120                 125             





Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 

    130                 135                 140                 





His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 

145                 150                 155                 160 





Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 

                165                 170                 175     





Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 

            180                 185                 190         





Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 

        195                 200                 205             





Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 

    210                 215                 220                 





Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 

225                 230                 235                 240 





Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 

                245                 250                 255     





Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 

            260                 265                 270         





Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro Leu Ala Val Asn Leu Leu 

        275                 280                 285             





Glu Lys Met Leu Val Leu Asp Ala Glu Gln Arg Val Thr Ala Gly Glu 

    290                 295                 300                 





Ala Leu Ala His Pro Tyr Phe Glu Ser Leu His Asp Thr Glu Asp Glu 

305                 310                 315                 320 





Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe Asp Asp Val Asp Arg Thr 

                325                 330                 335     





Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys 

            340                 345                 350         





Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 

        355                 360                 365         





<210>  235

<211>  357

<212>  PRT

<213>  Homo sapiens



<400>  235



Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 

1               5                   10                  15      





Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 

            20                  25                  30          





Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 

        35                  40                  45              





Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 

    50                  55                  60                  





Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 

65                  70                  75                  80  





Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 

                85                  90                  95      





Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 

            100                 105                 110         





Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 

        115                 120                 125             





Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Asp Leu 

    130                 135                 140                 





Lys Pro Gly Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu 

145                 150                 155                 160 





Asp Phe Gly Leu Ala Arg Gln Ala Asp Ser Glu Met Thr Gly Tyr Val 

                165                 170                 175     





Val Thr Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg 

            180                 185                 190         





Tyr Thr Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu 

        195                 200                 205             





Met Ile Thr Gly Lys Thr Leu Phe Lys Gly Ser Asp His Leu Asp Gln 

    210                 215                 220                 





Leu Lys Glu Ile Met Lys Val Thr Gly Thr Pro Pro Ala Glu Phe Val 

225                 230                 235                 240 





Gln Arg Leu Gln Ser Asp Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro 

                245                 250                 255     





Glu Leu Glu Lys Lys Asp Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro 

            260                 265                 270         





Leu Ala Val Asn Leu Leu Glu Lys Met Leu Val Leu Asp Ala Glu Gln 

        275                 280                 285             





Arg Val Thr Ala Gly Glu Ala Leu Ala His Pro Tyr Phe Glu Ser Leu 

    290                 295                 300                 





His Asp Thr Glu Asp Glu Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe 

305                 310                 315                 320 





Asp Asp Val Asp Arg Thr Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys 

                325                 330                 335     





Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser 

            340                 345                 350         





Lys Glu Thr Pro Leu 

        355         





<210>  236

<211>  543

<212>  PRT

<213>  Homo sapiens



<400>  236



Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 

1               5                   10                  15      





Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 

            20                  25                  30          





Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 

        35                  40                  45              





Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 

    50                  55                  60                  





Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 

65                  70                  75                  80  





Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 

                85                  90                  95      





Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 

            100                 105                 110         





Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 

        115                 120                 125             





Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 

    130                 135                 140                 





Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 

145                 150                 155                 160 





Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 

                165                 170                 175     





Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 

            180                 185                 190         





Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 

        195                 200                 205             





Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 

    210                 215                 220                 





Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 

225                 230                 235                 240 





Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 

                245                 250                 255     





Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 

            260                 265                 270         





Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 

        275                 280                 285             





Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 

    290                 295                 300                 





Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 

305                 310                 315                 320 





Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 

                325                 330                 335     





Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 

            340                 345                 350         





Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 

        355                 360                 365             





Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 

    370                 375                 380                 





Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 

385                 390                 395                 400 





His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 

                405                 410                 415     





Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 

            420                 425                 430         





Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 

        435                 440                 445             





Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 

    450                 455                 460                 





Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 

465                 470                 475                 480 





Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 

                485                 490                 495     





Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 

            500                 505                 510         





Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 

        515                 520                 525             





Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 

    530                 535                 540             





<210>  237

<211>  485

<212>  PRT

<213>  Homo sapiens



<400>  237



Met Arg Lys Arg Ala Pro Gln Ser Glu Met Ala Pro Ala Gly Val Ser 

1               5                   10                  15      





Leu Arg Ala Thr Ile Leu Cys Leu Leu Ala Trp Ala Gly Leu Ala Ala 

            20                  25                  30          





Gly Asp Arg Val Tyr Ile His Pro Phe His Leu Val Ile His Asn Glu 

        35                  40                  45              





Ser Thr Cys Glu Gln Leu Ala Lys Ala Asn Ala Gly Lys Pro Lys Asp 

    50                  55                  60                  





Pro Thr Phe Ile Pro Ala Pro Ile Gln Ala Lys Thr Ser Pro Val Asp 

65                  70                  75                  80  





Glu Lys Ala Leu Gln Asp Gln Leu Val Leu Val Ala Ala Lys Leu Asp 

                85                  90                  95      





Thr Glu Asp Lys Leu Arg Ala Ala Met Val Gly Met Leu Ala Asn Phe 

            100                 105                 110         





Leu Gly Phe Arg Ile Tyr Gly Met His Ser Glu Leu Trp Gly Val Val 

        115                 120                 125             





His Gly Ala Thr Val Leu Ser Pro Thr Ala Val Phe Gly Thr Leu Ala 

    130                 135                 140                 





Ser Leu Tyr Leu Gly Ala Leu Asp His Thr Ala Asp Arg Leu Gln Ala 

145                 150                 155                 160 





Ile Leu Gly Val Pro Trp Lys Asp Lys Asn Cys Thr Ser Arg Leu Asp 

                165                 170                 175     





Ala His Lys Val Leu Ser Ala Leu Gln Ala Val Gln Gly Leu Leu Val 

            180                 185                 190         





Ala Gln Gly Arg Ala Asp Ser Gln Ala Gln Leu Leu Leu Ser Thr Val 

        195                 200                 205             





Val Gly Val Phe Thr Ala Pro Gly Leu His Leu Lys Gln Pro Phe Val 

    210                 215                 220                 





Gln Gly Leu Ala Leu Tyr Thr Pro Val Val Leu Pro Arg Ser Leu Asp 

225                 230                 235                 240 





Phe Thr Glu Leu Asp Val Ala Ala Glu Lys Ile Asp Arg Phe Met Gln 

                245                 250                 255     





Ala Val Thr Gly Trp Lys Thr Gly Cys Ser Leu Met Gly Ala Ser Val 

            260                 265                 270         





Asp Ser Thr Leu Ala Phe Asn Thr Tyr Val His Phe Gln Gly Lys Met 

        275                 280                 285             





Lys Gly Phe Ser Leu Leu Ala Glu Pro Gln Glu Phe Trp Val Asp Asn 

    290                 295                 300                 





Ser Thr Ser Val Ser Val Pro Met Leu Ser Gly Met Gly Thr Phe Gln 

305                 310                 315                 320 





His Trp Ser Asp Ile Gln Asp Asn Phe Ser Val Thr Gln Val Pro Phe 

                325                 330                 335     





Thr Glu Ser Ala Cys Leu Leu Leu Ile Gln Pro His Tyr Ala Ser Asp 

            340                 345                 350         





Leu Asp Lys Val Glu Gly Leu Thr Phe Gln Gln Asn Ser Leu Asn Trp 

        355                 360                 365             





Met Lys Lys Leu Ser Pro Arg Thr Ile His Leu Thr Met Pro Gln Leu 

    370                 375                 380                 





Val Leu Gln Gly Ser Tyr Asp Leu Gln Asp Leu Leu Ala Gln Ala Glu 

385                 390                 395                 400 





Leu Pro Ala Ile Leu His Thr Glu Leu Asn Leu Gln Lys Leu Ser Asn 

                405                 410                 415     





Asp Arg Ile Arg Val Gly Glu Val Leu Asn Ser Ile Phe Phe Glu Leu 

            420                 425                 430         





Glu Ala Asp Glu Arg Glu Pro Thr Glu Ser Thr Gln Gln Leu Asn Lys 

        435                 440                 445             





Pro Glu Val Leu Glu Val Thr Leu Asn Arg Pro Phe Leu Phe Ala Val 

    450                 455                 460                 





Tyr Asp Gln Ser Ala Thr Ala Leu His Phe Leu Gly Arg Val Ala Asn 

465                 470                 475                 480 





Pro Leu Ser Thr Ala 

                485 





<210>  238

<211>  2843

<212>  PRT

<213>  Homo sapiens



<400>  238



Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 

1               5                   10                  15      





Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 

            20                  25                  30          





His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu 

        35                  40                  45              





Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 

    50                  55                  60                  





Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 

65                  70                  75                  80  





Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 

                85                  90                  95      





Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 

            100                 105                 110         





Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 

        115                 120                 125             





Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 

    130                 135                 140                 





Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 

145                 150                 155                 160 





Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu 

                165                 170                 175     





Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu 

            180                 185                 190         





Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln 

        195                 200                 205             





Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 

    210                 215                 220                 





Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr 

225                 230                 235                 240 





Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp 

                245                 250                 255     





Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 

            260                 265                 270         





Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr 

        275                 280                 285             





Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu 

    290                 295                 300                 





Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser 

305                 310                 315                 320 





Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala 

                325                 330                 335     





Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys 

            340                 345                 350         





Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val 

        355                 360                 365             





Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser 

    370                 375                 380                 





Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly 

385                 390                 395                 400 





Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr 

                405                 410                 415     





Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp 

            420                 425                 430         





Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro 

        435                 440                 445             





Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His 

    450                 455                 460                 





Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln 

465                 470                 475                 480 





Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr 

                485                 490                 495     





Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp 

            500                 505                 510         





Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala 

        515                 520                 525             





Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile 

    530                 535                 540                 





Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys 

545                 550                 555                 560 





Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala 

                565                 570                 575     





Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu 

            580                 585                 590         





Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala 

        595                 600                 605             





Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser 

    610                 615                 620                 





Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg 

625                 630                 635                 640 





Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu 

                645                 650                 655     





Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His 

            660                 665                 670         





Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser 

        675                 680                 685             





Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val 

    690                 695                 700                 





Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met 

705                 710                 715                 720 





Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys 

                725                 730                 735     





Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu 

            740                 745                 750         





His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His 

        755                 760                 765             





Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser 

    770                 775                 780                 





His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val 

785                 790                 795                 800 





Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr 

                805                 810                 815     





Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro 

            820                 825                 830         





Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys 

        835                 840                 845             





Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His 

    850                 855                 860                 





Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile 

865                 870                 875                 880 





Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala 

                885                 890                 895     





Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu 

            900                 905                 910         





His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala 

        915                 920                 925             





His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn 

    930                 935                 940                 





Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser 

945                 950                 955                 960 





Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg 

                965                 970                 975     





Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser 

            980                 985                 990         





Lys Phe Cys Ser Tyr Gly Gln Tyr  Pro Ala Asp Leu Ala  His Lys Ile 

        995                 1000                 1005             





His Ser  Ala Asn His Met Asp  Asp Asn Asp Gly Glu  Leu Asp Thr 

    1010                 1015                 1020             





Pro Ile  Asn Tyr Ser Leu Lys  Tyr Ser Asp Glu Gln  Leu Asn Ser 

    1025                 1030                 1035             





Gly Arg  Gln Ser Pro Ser Gln  Asn Glu Arg Trp Ala  Arg Pro Lys 

    1040                 1045                 1050             





His Ile  Ile Glu Asp Glu Ile  Lys Gln Ser Glu Gln  Arg Gln Ser 

    1055                 1060                 1065             





Arg Asn  Gln Ser Thr Thr Tyr  Pro Val Tyr Thr Glu  Ser Thr Asp 

    1070                 1075                 1080             





Asp Lys  His Leu Lys Phe Gln  Pro His Phe Gly Gln  Gln Glu Cys 

    1085                 1090                 1095             





Val Ser  Pro Tyr Arg Ser Arg  Gly Ala Asn Gly Ser  Glu Thr Asn 

    1100                 1105                 1110             





Arg Val  Gly Ser Asn His Gly  Ile Asn Gln Asn Val  Ser Gln Ser 

    1115                 1120                 1125             





Leu Cys  Gln Glu Asp Asp Tyr  Glu Asp Asp Lys Pro  Thr Asn Tyr 

    1130                 1135                 1140             





Ser Glu  Arg Tyr Ser Glu Glu  Glu Gln His Glu Glu  Glu Glu Arg 

    1145                 1150                 1155             





Pro Thr  Asn Tyr Ser Ile Lys  Tyr Asn Glu Glu Lys  Arg His Val 

    1160                 1165                 1170             





Asp Gln  Pro Ile Asp Tyr Ser  Leu Lys Tyr Ala Thr  Asp Ile Pro 

    1175                 1180                 1185             





Ser Ser  Gln Lys Gln Ser Phe  Ser Phe Ser Lys Ser  Ser Ser Gly 

    1190                 1195                 1200             





Gln Ser  Ser Lys Thr Glu His  Met Ser Ser Ser Ser  Glu Asn Thr 

    1205                 1210                 1215             





Ser Thr  Pro Ser Ser Asn Ala  Lys Arg Gln Asn Gln  Leu His Pro 

    1220                 1225                 1230             





Ser Ser  Ala Gln Ser Arg Ser  Gly Gln Pro Gln Lys  Ala Ala Thr 

    1235                 1240                 1245             





Cys Lys  Val Ser Ser Ile Asn  Gln Glu Thr Ile Gln  Thr Tyr Cys 

    1250                 1255                 1260             





Val Glu  Asp Thr Pro Ile Cys  Phe Ser Arg Cys Ser  Ser Leu Ser 

    1265                 1270                 1275             





Ser Leu  Ser Ser Ala Glu Asp  Glu Ile Gly Cys Asn  Gln Thr Thr 

    1280                 1285                 1290             





Gln Glu  Ala Asp Ser Ala Asn  Thr Leu Gln Ile Ala  Glu Ile Lys 

    1295                 1300                 1305             





Glu Lys  Ile Gly Thr Arg Ser  Ala Glu Asp Pro Val  Ser Glu Val 

    1310                 1315                 1320             





Pro Ala  Val Ser Gln His Pro  Arg Thr Lys Ser Ser  Arg Leu Gln 

    1325                 1330                 1335             





Gly Ser  Ser Leu Ser Ser Glu  Ser Ala Arg His Lys  Ala Val Glu 

    1340                 1345                 1350             





Phe Ser  Ser Gly Ala Lys Ser  Pro Ser Lys Ser Gly  Ala Gln Thr 

    1355                 1360                 1365             





Pro Lys  Ser Pro Pro Glu His  Tyr Val Gln Glu Thr  Pro Leu Met 

    1370                 1375                 1380             





Phe Ser  Arg Cys Thr Ser Val  Ser Ser Leu Asp Ser  Phe Glu Ser 

    1385                 1390                 1395             





Arg Ser  Ile Ala Ser Ser Val  Gln Ser Glu Pro Cys  Ser Gly Met 

    1400                 1405                 1410             





Val Ser  Gly Ile Ile Ser Pro  Ser Asp Leu Pro Asp  Ser Pro Gly 

    1415                 1420                 1425             





Gln Thr  Met Pro Pro Ser Arg  Ser Lys Thr Pro Pro  Pro Pro Pro 

    1430                 1435                 1440             





Gln Thr  Ala Gln Thr Lys Arg  Glu Val Pro Lys Asn  Lys Ala Pro 

    1445                 1450                 1455             





Thr Ala  Glu Lys Arg Glu Ser  Gly Pro Lys Gln Ala  Ala Val Asn 

    1460                 1465                 1470             





Ala Ala  Val Gln Arg Val Gln  Val Leu Pro Asp Ala  Asp Thr Leu 

    1475                 1480                 1485             





Leu His  Phe Ala Thr Glu Ser  Thr Pro Asp Gly Phe  Ser Cys Ser 

    1490                 1495                 1500             





Ser Ser  Leu Ser Ala Leu Ser  Leu Asp Glu Pro Phe  Ile Gln Lys 

    1505                 1510                 1515             





Asp Val  Glu Leu Arg Ile Met  Pro Pro Val Gln Glu  Asn Asp Asn 

    1520                 1525                 1530             





Gly Asn  Glu Thr Glu Ser Glu  Gln Pro Lys Glu Ser  Asn Glu Asn 

    1535                 1540                 1545             





Gln Glu  Lys Glu Ala Glu Lys  Thr Ile Asp Ser Glu  Lys Asp Leu 

    1550                 1555                 1560             





Leu Asp  Asp Ser Asp Asp Asp  Asp Ile Glu Ile Leu  Glu Glu Cys 

    1565                 1570                 1575             





Ile Ile  Ser Ala Met Pro Thr  Lys Ser Ser Arg Lys  Ala Lys Lys 

    1580                 1585                 1590             





Pro Ala  Gln Thr Ala Ser Lys  Leu Pro Pro Pro Val  Ala Arg Lys 

    1595                 1600                 1605             





Pro Ser  Gln Leu Pro Val Tyr  Lys Leu Leu Pro Ser  Gln Asn Arg 

    1610                 1615                 1620             





Leu Gln  Pro Gln Lys His Val  Ser Phe Thr Pro Gly  Asp Asp Met 

    1625                 1630                 1635             





Pro Arg  Val Tyr Cys Val Glu  Gly Thr Pro Ile Asn  Phe Ser Thr 

    1640                 1645                 1650             





Ala Thr  Ser Leu Ser Asp Leu  Thr Ile Glu Ser Pro  Pro Asn Glu 

    1655                 1660                 1665             





Leu Ala  Ala Gly Glu Gly Val  Arg Gly Gly Ala Gln  Ser Gly Glu 

    1670                 1675                 1680             





Phe Glu  Lys Arg Asp Thr Ile  Pro Thr Glu Gly Arg  Ser Thr Asp 

    1685                 1690                 1695             





Glu Ala  Gln Gly Gly Lys Thr  Ser Ser Val Thr Ile  Pro Glu Leu 

    1700                 1705                 1710             





Asp Asp  Asn Lys Ala Glu Glu  Gly Asp Ile Leu Ala  Glu Cys Ile 

    1715                 1720                 1725             





Asn Ser  Ala Met Pro Lys Gly  Lys Ser His Lys Pro  Phe Arg Val 

    1730                 1735                 1740             





Lys Lys  Ile Met Asp Gln Val  Gln Gln Ala Ser Ala  Ser Ser Ser 

    1745                 1750                 1755             





Ala Pro  Asn Lys Asn Gln Leu  Asp Gly Lys Lys Lys  Lys Pro Thr 

    1760                 1765                 1770             





Ser Pro  Val Lys Pro Ile Pro  Gln Asn Thr Glu Tyr  Arg Thr Arg 

    1775                 1780                 1785             





Val Arg  Lys Asn Ala Asp Ser  Lys Asn Asn Leu Asn  Ala Glu Arg 

    1790                 1795                 1800             





Val Phe  Ser Asp Asn Lys Asp  Ser Lys Lys Gln Asn  Leu Lys Asn 

    1805                 1810                 1815             





Asn Ser  Lys Val Phe Asn Asp  Lys Leu Pro Asn Asn  Glu Asp Arg 

    1820                 1825                 1830             





Val Arg  Gly Ser Phe Ala Phe  Asp Ser Pro His His  Tyr Thr Pro 

    1835                 1840                 1845             





Ile Glu  Gly Thr Pro Tyr Cys  Phe Ser Arg Asn Asp  Ser Leu Ser 

    1850                 1855                 1860             





Ser Leu  Asp Phe Asp Asp Asp  Asp Val Asp Leu Ser  Arg Glu Lys 

    1865                 1870                 1875             





Ala Glu  Leu Arg Lys Ala Lys  Glu Asn Lys Glu Ser  Glu Ala Lys 

    1880                 1885                 1890             





Val Thr  Ser His Thr Glu Leu  Thr Ser Asn Gln Gln  Ser Ala Asn 

    1895                 1900                 1905             





Lys Thr  Gln Ala Ile Ala Lys  Gln Pro Ile Asn Arg  Gly Gln Pro 

    1910                 1915                 1920             





Lys Pro  Ile Leu Gln Lys Gln  Ser Thr Phe Pro Gln  Ser Ser Lys 

    1925                 1930                 1935             





Asp Ile  Pro Asp Arg Gly Ala  Ala Thr Asp Glu Lys  Leu Gln Asn 

    1940                 1945                 1950             





Phe Ala  Ile Glu Asn Thr Pro  Val Cys Phe Ser His  Asn Ser Ser 

    1955                 1960                 1965             





Leu Ser  Ser Leu Ser Asp Ile  Asp Gln Glu Asn Asn  Asn Lys Glu 

    1970                 1975                 1980             





Asn Glu  Pro Ile Lys Glu Thr  Glu Pro Pro Asp Ser  Gln Gly Glu 

    1985                 1990                 1995             





Pro Ser  Lys Pro Gln Ala Ser  Gly Tyr Ala Pro Lys  Ser Phe His 

    2000                 2005                 2010             





Val Glu  Asp Thr Pro Val Cys  Phe Ser Arg Asn Ser  Ser Leu Ser 

    2015                 2020                 2025             





Ser Leu  Ser Ile Asp Ser Glu  Asp Asp Leu Leu Gln  Glu Cys Ile 

    2030                 2035                 2040             





Ser Ser  Ala Met Pro Lys Lys  Lys Lys Pro Ser Arg  Leu Lys Gly 

    2045                 2050                 2055             





Asp Asn  Glu Lys His Ser Pro  Arg Asn Met Gly Gly  Ile Leu Gly 

    2060                 2065                 2070             





Glu Asp  Leu Thr Leu Asp Leu  Lys Asp Ile Gln Arg  Pro Asp Ser 

    2075                 2080                 2085             





Glu His  Gly Leu Ser Pro Asp  Ser Glu Asn Phe Asp  Trp Lys Ala 

    2090                 2095                 2100             





Ile Gln  Glu Gly Ala Asn Ser  Ile Val Ser Ser Leu  His Gln Ala 

    2105                 2110                 2115             





Ala Ala  Ala Ala Cys Leu Ser  Arg Gln Ala Ser Ser  Asp Ser Asp 

    2120                 2125                 2130             





Ser Ile  Leu Ser Leu Lys Ser  Gly Ile Ser Leu Gly  Ser Pro Phe 

    2135                 2140                 2145             





His Leu  Thr Pro Asp Gln Glu  Glu Lys Pro Phe Thr  Ser Asn Lys 

    2150                 2155                 2160             





Gly Pro  Arg Ile Leu Lys Pro  Gly Glu Lys Ser Thr  Leu Glu Thr 

    2165                 2170                 2175             





Lys Lys  Ile Glu Ser Glu Ser  Lys Gly Ile Lys Gly  Gly Lys Lys 

    2180                 2185                 2190             





Val Tyr  Lys Ser Leu Ile Thr  Gly Lys Val Arg Ser  Asn Ser Glu 

    2195                 2200                 2205             





Ile Ser  Gly Gln Met Lys Gln  Pro Leu Gln Ala Asn  Met Pro Ser 

    2210                 2215                 2220             





Ile Ser  Arg Gly Arg Thr Met  Ile His Ile Pro Gly  Val Arg Asn 

    2225                 2230                 2235             





Ser Ser  Ser Ser Thr Ser Pro  Val Ser Lys Lys Gly  Pro Pro Leu 

    2240                 2245                 2250             





Lys Thr  Pro Ala Ser Lys Ser  Pro Ser Glu Gly Gln  Thr Ala Thr 

    2255                 2260                 2265             





Thr Ser  Pro Arg Gly Ala Lys  Pro Ser Val Lys Ser  Glu Leu Ser 

    2270                 2275                 2280             





Pro Val  Ala Arg Gln Thr Ser  Gln Ile Gly Gly Ser  Ser Lys Ala 

    2285                 2290                 2295             





Pro Ser  Arg Ser Gly Ser Arg  Asp Ser Thr Pro Ser  Arg Pro Ala 

    2300                 2305                 2310             





Gln Gln  Pro Leu Ser Arg Pro  Ile Gln Ser Pro Gly  Arg Asn Ser 

    2315                 2320                 2325             





Ile Ser  Pro Gly Arg Asn Gly  Ile Ser Pro Pro Asn  Lys Leu Ser 

    2330                 2335                 2340             





Gln Leu  Pro Arg Thr Ser Ser  Pro Ser Thr Ala Ser  Thr Lys Ser 

    2345                 2350                 2355             





Ser Gly  Ser Gly Lys Met Ser  Tyr Thr Ser Pro Gly  Arg Gln Met 

    2360                 2365                 2370             





Ser Gln  Gln Asn Leu Thr Lys  Gln Thr Gly Leu Ser  Lys Asn Ala 

    2375                 2380                 2385             





Ser Ser  Ile Pro Arg Ser Glu  Ser Ala Ser Lys Gly  Leu Asn Gln 

    2390                 2395                 2400             





Met Asn  Asn Gly Asn Gly Ala  Asn Lys Lys Val Glu  Leu Ser Arg 

    2405                 2410                 2415             





Met Ser  Ser Thr Lys Ser Ser  Gly Ser Glu Ser Asp  Arg Ser Glu 

    2420                 2425                 2430             





Arg Pro  Val Leu Val Arg Gln  Ser Thr Phe Ile Lys  Glu Ala Pro 

    2435                 2440                 2445             





Ser Pro  Thr Leu Arg Arg Lys  Leu Glu Glu Ser Ala  Ser Phe Glu 

    2450                 2455                 2460             





Ser Leu  Ser Pro Ser Ser Arg  Pro Ala Ser Pro Thr  Arg Ser Gln 

    2465                 2470                 2475             





Ala Gln  Thr Pro Val Leu Ser  Pro Ser Leu Pro Asp  Met Ser Leu 

    2480                 2485                 2490             





Ser Thr  His Ser Ser Val Gln  Ala Gly Gly Trp Arg  Lys Leu Pro 

    2495                 2500                 2505             





Pro Asn  Leu Ser Pro Thr Ile  Glu Tyr Asn Asp Gly  Arg Pro Ala 

    2510                 2515                 2520             





Lys Arg  His Asp Ile Ala Arg  Ser His Ser Glu Ser  Pro Ser Arg 

    2525                 2530                 2535             





Leu Pro  Ile Asn Arg Ser Gly  Thr Trp Lys Arg Glu  His Ser Lys 

    2540                 2545                 2550             





His Ser  Ser Ser Leu Pro Arg  Val Ser Thr Trp Arg  Arg Thr Gly 

    2555                 2560                 2565             





Ser Ser  Ser Ser Ile Leu Ser  Ala Ser Ser Glu Ser  Ser Glu Lys 

    2570                 2575                 2580             





Ala Lys  Ser Glu Asp Glu Lys  His Val Asn Ser Ile  Ser Gly Thr 

    2585                 2590                 2595             





Lys Gln  Ser Lys Glu Asn Gln  Val Ser Ala Lys Gly  Thr Trp Arg 

    2600                 2605                 2610             





Lys Ile  Lys Glu Asn Glu Phe  Ser Pro Thr Asn Ser  Thr Ser Gln 

    2615                 2620                 2625             





Thr Val  Ser Ser Gly Ala Thr  Asn Gly Ala Glu Ser  Lys Thr Leu 

    2630                 2635                 2640             





Ile Tyr  Gln Met Ala Pro Ala  Val Ser Lys Thr Glu  Asp Val Trp 

    2645                 2650                 2655             





Val Arg  Ile Glu Asp Cys Pro  Ile Asn Asn Pro Arg  Ser Gly Arg 

    2660                 2665                 2670             





Ser Pro  Thr Gly Asn Thr Pro  Pro Val Ile Asp Ser  Val Ser Glu 

    2675                 2680                 2685             





Lys Ala  Asn Pro Asn Ile Lys  Asp Ser Lys Asp Asn  Gln Ala Lys 

    2690                 2695                 2700             





Gln Asn  Val Gly Asn Gly Ser  Val Pro Met Arg Thr  Val Gly Leu 

    2705                 2710                 2715             





Glu Asn  Arg Leu Asn Ser Phe  Ile Gln Val Asp Ala  Pro Asp Gln 

    2720                 2725                 2730             





Lys Gly  Thr Glu Ile Lys Pro  Gly Gln Asn Asn Pro  Val Pro Val 

    2735                 2740                 2745             





Ser Glu  Thr Asn Glu Ser Ser  Ile Val Glu Arg Thr  Pro Phe Ser 

    2750                 2755                 2760             





Ser Ser  Ser Ser Ser Lys His  Ser Ser Pro Ser Gly  Thr Val Ala 

    2765                 2770                 2775             





Ala Arg  Val Thr Pro Phe Asn  Tyr Asn Pro Ser Pro  Arg Lys Ser 

    2780                 2785                 2790             





Ser Ala  Asp Ser Thr Ser Ala  Arg Pro Ser Gln Ile  Pro Thr Pro 

    2795                 2800                 2805             





Val Asn  Asn Asn Thr Lys Lys  Arg Asp Ser Lys Thr  Asp Ser Thr 

    2810                 2815                 2820             





Glu Ser  Ser Gly Thr Gln Ser  Pro Lys Arg His Ser  Gly Ser Tyr 

    2825                 2830                 2835             





Leu Val  Thr Ser Val 

    2840             





<210>  239

<211>  2742

<212>  PRT

<213>  Homo sapiens



<400>  239



Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 

1               5                   10                  15      





Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 

            20                  25                  30          





His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu 

        35                  40                  45              





Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 

    50                  55                  60                  





Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 

65                  70                  75                  80  





Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 

                85                  90                  95      





Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 

            100                 105                 110         





Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 

        115                 120                 125             





Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 

    130                 135                 140                 





Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 

145                 150                 155                 160 





Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu 

                165                 170                 175     





Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu 

            180                 185                 190         





Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln 

        195                 200                 205             





Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 

    210                 215                 220                 





Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr 

225                 230                 235                 240 





Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp 

                245                 250                 255     





Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 

            260                 265                 270         





Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr 

        275                 280                 285             





Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu 

    290                 295                 300                 





Thr Ser His Leu Gly Thr Lys Ile Arg Ala Tyr Cys Glu Thr Cys Trp 

305                 310                 315                 320 





Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp Gln Asp Lys Asn Pro 

                325                 330                 335     





Met Pro Ala Pro Val Glu His Gln Ile Cys Pro Ala Val Cys Val Leu 

            340                 345                 350         





Met Lys Leu Ser Phe Asp Glu Glu His Arg His Ala Met Asn Glu Leu 

        355                 360                 365             





Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln Val Asp Cys Glu Met 

    370                 375                 380                 





Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr Leu Arg Arg Tyr Ala 

385                 390                 395                 400 





Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp Val Ala Asn Lys Ala 

                405                 410                 415     





Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala Leu Val Ala Gln Leu 

            420                 425                 430         





Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile Ala Ser Val Leu Arg 

        435                 440                 445             





Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys Lys Thr Leu Arg Glu 

    450                 455                 460                 





Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala Leu Glu Val Lys Lys 

465                 470                 475                 480 





Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu Trp Asn Leu Ser Ala 

                485                 490                 495     





His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala Val Asp Gly Ala Leu 

            500                 505                 510         





Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser Gln Thr Asn Thr Leu 

        515                 520                 525             





Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val Ser Ser Leu 

    530                 535                 540                 





Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu Arg Glu Asn Asn Cys 

545                 550                 555                 560 





Leu Gln Thr Leu Leu Gln His Leu Lys Ser His Ser Leu Thr Ile Val 

                565                 570                 575     





Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser Ala Arg Asn Pro Lys 

            580                 585                 590         





Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val Ser Met Leu Lys Asn 

        595                 600                 605             





Leu Ile His Ser Lys His Lys Met Ile Ala Met Gly Ser Ala Ala Ala 

    610                 615                 620                 





Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys Tyr Lys Asp Ala Asn 

625                 630                 635                 640 





Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu His Val Arg Lys Gln 

                645                 650                 655     





Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His Leu Ser Glu Thr Phe 

            660                 665                 670         





Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser His Arg Ser Lys Gln 

        675                 680                 685             





Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val Phe Asp Thr Asn Arg 

    690                 695                 700                 





His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr Gly Asn Met Thr Val 

705                 710                 715                 720 





Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro Ser Ser Ser Ser Ser 

                725                 730                 735     





Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys Asp Arg Ser Leu Glu 

            740                 745                 750         





Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His Pro Ala Thr Glu Asn 

        755                 760                 765             





Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile Ser Thr Thr Ala Ala 

    770                 775                 780                 





Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala Ile His Thr Ser Gln 

785                 790                 795                 800 





Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu His Cys Val Thr Asp 

                805                 810                 815     





Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala His Thr His Ser Asn 

            820                 825                 830         





Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn Arg Thr Cys Ser Met 

        835                 840                 845             





Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser Asn Asp Ser Leu Asn 

    850                 855                 860                 





Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg Gly Gln Met Lys Pro 

865                 870                 875                 880 





Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser Lys Phe Cys Ser Tyr 

                885                 890                 895     





Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile His Ser Ala Asn His 

            900                 905                 910         





Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro Ile Asn Tyr Ser Leu 

        915                 920                 925             





Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg Gln Ser Pro Ser Gln 

    930                 935                 940                 





Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile Glu Asp Glu Ile Lys 

945                 950                 955                 960 





Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser Thr Thr Tyr Pro Val 

                965                 970                 975     





Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys Phe Gln Pro His Phe 

            980                 985                 990         





Gly Gln Gln Glu Cys Val Ser Pro  Tyr Arg Ser Arg Gly  Ala Asn Gly 

        995                 1000                 1005             





Ser Glu  Thr Asn Arg Val Gly  Ser Asn His Gly Ile  Asn Gln Asn 

    1010                 1015                 1020             





Val Ser  Gln Ser Leu Cys Gln  Glu Asp Asp Tyr Glu  Asp Asp Lys 

    1025                 1030                 1035             





Pro Thr  Asn Tyr Ser Glu Arg  Tyr Ser Glu Glu Glu  Gln His Glu 

    1040                 1045                 1050             





Glu Glu  Glu Arg Pro Thr Asn  Tyr Ser Ile Lys Tyr  Asn Glu Glu 

    1055                 1060                 1065             





Lys Arg  His Val Asp Gln Pro  Ile Asp Tyr Ser Leu  Lys Tyr Ala 

    1070                 1075                 1080             





Thr Asp  Ile Pro Ser Ser Gln  Lys Gln Ser Phe Ser  Phe Ser Lys 

    1085                 1090                 1095             





Ser Ser  Ser Gly Gln Ser Ser  Lys Thr Glu His Met  Ser Ser Ser 

    1100                 1105                 1110             





Ser Glu  Asn Thr Ser Thr Pro  Ser Ser Asn Ala Lys  Arg Gln Asn 

    1115                 1120                 1125             





Gln Leu  His Pro Ser Ser Ala  Gln Ser Arg Ser Gly  Gln Pro Gln 

    1130                 1135                 1140             





Lys Ala  Ala Thr Cys Lys Val  Ser Ser Ile Asn Gln  Glu Thr Ile 

    1145                 1150                 1155             





Gln Thr  Tyr Cys Val Glu Asp  Thr Pro Ile Cys Phe  Ser Arg Cys 

    1160                 1165                 1170             





Ser Ser  Leu Ser Ser Leu Ser  Ser Ala Glu Asp Glu  Ile Gly Cys 

    1175                 1180                 1185             





Asn Gln  Thr Thr Gln Glu Ala  Asp Ser Ala Asn Thr  Leu Gln Ile 

    1190                 1195                 1200             





Ala Glu  Ile Lys Glu Lys Ile  Gly Thr Arg Ser Ala  Glu Asp Pro 

    1205                 1210                 1215             





Val Ser  Glu Val Pro Ala Val  Ser Gln His Pro Arg  Thr Lys Ser 

    1220                 1225                 1230             





Ser Arg  Leu Gln Gly Ser Ser  Leu Ser Ser Glu Ser  Ala Arg His 

    1235                 1240                 1245             





Lys Ala  Val Glu Phe Ser Ser  Gly Ala Lys Ser Pro  Ser Lys Ser 

    1250                 1255                 1260             





Gly Ala  Gln Thr Pro Lys Ser  Pro Pro Glu His Tyr  Val Gln Glu 

    1265                 1270                 1275             





Thr Pro  Leu Met Phe Ser Arg  Cys Thr Ser Val Ser  Ser Leu Asp 

    1280                 1285                 1290             





Ser Phe  Glu Ser Arg Ser Ile  Ala Ser Ser Val Gln  Ser Glu Pro 

    1295                 1300                 1305             





Cys Ser  Gly Met Val Ser Gly  Ile Ile Ser Pro Ser  Asp Leu Pro 

    1310                 1315                 1320             





Asp Ser  Pro Gly Gln Thr Met  Pro Pro Ser Arg Ser  Lys Thr Pro 

    1325                 1330                 1335             





Pro Pro  Pro Pro Gln Thr Ala  Gln Thr Lys Arg Glu  Val Pro Lys 

    1340                 1345                 1350             





Asn Lys  Ala Pro Thr Ala Glu  Lys Arg Glu Ser Gly  Pro Lys Gln 

    1355                 1360                 1365             





Ala Ala  Val Asn Ala Ala Val  Gln Arg Val Gln Val  Leu Pro Asp 

    1370                 1375                 1380             





Ala Asp  Thr Leu Leu His Phe  Ala Thr Glu Ser Thr  Pro Asp Gly 

    1385                 1390                 1395             





Phe Ser  Cys Ser Ser Ser Leu  Ser Ala Leu Ser Leu  Asp Glu Pro 

    1400                 1405                 1410             





Phe Ile  Gln Lys Asp Val Glu  Leu Arg Ile Met Pro  Pro Val Gln 

    1415                 1420                 1425             





Glu Asn  Asp Asn Gly Asn Glu  Thr Glu Ser Glu Gln  Pro Lys Glu 

    1430                 1435                 1440             





Ser Asn  Glu Asn Gln Glu Lys  Glu Ala Glu Lys Thr  Ile Asp Ser 

    1445                 1450                 1455             





Glu Lys  Asp Leu Leu Asp Asp  Ser Asp Asp Asp Asp  Ile Glu Ile 

    1460                 1465                 1470             





Leu Glu  Glu Cys Ile Ile Ser  Ala Met Pro Thr Lys  Ser Ser Arg 

    1475                 1480                 1485             





Lys Ala  Lys Lys Pro Ala Gln  Thr Ala Ser Lys Leu  Pro Pro Pro 

    1490                 1495                 1500             





Val Ala  Arg Lys Pro Ser Gln  Leu Pro Val Tyr Lys  Leu Leu Pro 

    1505                 1510                 1515             





Ser Gln  Asn Arg Leu Gln Pro  Gln Lys His Val Ser  Phe Thr Pro 

    1520                 1525                 1530             





Gly Asp  Asp Met Pro Arg Val  Tyr Cys Val Glu Gly  Thr Pro Ile 

    1535                 1540                 1545             





Asn Phe  Ser Thr Ala Thr Ser  Leu Ser Asp Leu Thr  Ile Glu Ser 

    1550                 1555                 1560             





Pro Pro  Asn Glu Leu Ala Ala  Gly Glu Gly Val Arg  Gly Gly Ala 

    1565                 1570                 1575             





Gln Ser  Gly Glu Phe Glu Lys  Arg Asp Thr Ile Pro  Thr Glu Gly 

    1580                 1585                 1590             





Arg Ser  Thr Asp Glu Ala Gln  Gly Gly Lys Thr Ser  Ser Val Thr 

    1595                 1600                 1605             





Ile Pro  Glu Leu Asp Asp Asn  Lys Ala Glu Glu Gly  Asp Ile Leu 

    1610                 1615                 1620             





Ala Glu  Cys Ile Asn Ser Ala  Met Pro Lys Gly Lys  Ser His Lys 

    1625                 1630                 1635             





Pro Phe  Arg Val Lys Lys Ile  Met Asp Gln Val Gln  Gln Ala Ser 

    1640                 1645                 1650             





Ala Ser  Ser Ser Ala Pro Asn  Lys Asn Gln Leu Asp  Gly Lys Lys 

    1655                 1660                 1665             





Lys Lys  Pro Thr Ser Pro Val  Lys Pro Ile Pro Gln  Asn Thr Glu 

    1670                 1675                 1680             





Tyr Arg  Thr Arg Val Arg Lys  Asn Ala Asp Ser Lys  Asn Asn Leu 

    1685                 1690                 1695             





Asn Ala  Glu Arg Val Phe Ser  Asp Asn Lys Asp Ser  Lys Lys Gln 

    1700                 1705                 1710             





Asn Leu  Lys Asn Asn Ser Lys  Val Phe Asn Asp Lys  Leu Pro Asn 

    1715                 1720                 1725             





Asn Glu  Asp Arg Val Arg Gly  Ser Phe Ala Phe Asp  Ser Pro His 

    1730                 1735                 1740             





His Tyr  Thr Pro Ile Glu Gly  Thr Pro Tyr Cys Phe  Ser Arg Asn 

    1745                 1750                 1755             





Asp Ser  Leu Ser Ser Leu Asp  Phe Asp Asp Asp Asp  Val Asp Leu 

    1760                 1765                 1770             





Ser Arg  Glu Lys Ala Glu Leu  Arg Lys Ala Lys Glu  Asn Lys Glu 

    1775                 1780                 1785             





Ser Glu  Ala Lys Val Thr Ser  His Thr Glu Leu Thr  Ser Asn Gln 

    1790                 1795                 1800             





Gln Ser  Ala Asn Lys Thr Gln  Ala Ile Ala Lys Gln  Pro Ile Asn 

    1805                 1810                 1815             





Arg Gly  Gln Pro Lys Pro Ile  Leu Gln Lys Gln Ser  Thr Phe Pro 

    1820                 1825                 1830             





Gln Ser  Ser Lys Asp Ile Pro  Asp Arg Gly Ala Ala  Thr Asp Glu 

    1835                 1840                 1845             





Lys Leu  Gln Asn Phe Ala Ile  Glu Asn Thr Pro Val  Cys Phe Ser 

    1850                 1855                 1860             





His Asn  Ser Ser Leu Ser Ser  Leu Ser Asp Ile Asp  Gln Glu Asn 

    1865                 1870                 1875             





Asn Asn  Lys Glu Asn Glu Pro  Ile Lys Glu Thr Glu  Pro Pro Asp 

    1880                 1885                 1890             





Ser Gln  Gly Glu Pro Ser Lys  Pro Gln Ala Ser Gly  Tyr Ala Pro 

    1895                 1900                 1905             





Lys Ser  Phe His Val Glu Asp  Thr Pro Val Cys Phe  Ser Arg Asn 

    1910                 1915                 1920             





Ser Ser  Leu Ser Ser Leu Ser  Ile Asp Ser Glu Asp  Asp Leu Leu 

    1925                 1930                 1935             





Gln Glu  Cys Ile Ser Ser Ala  Met Pro Lys Lys Lys  Lys Pro Ser 

    1940                 1945                 1950             





Arg Leu  Lys Gly Asp Asn Glu  Lys His Ser Pro Arg  Asn Met Gly 

    1955                 1960                 1965             





Gly Ile  Leu Gly Glu Asp Leu  Thr Leu Asp Leu Lys  Asp Ile Gln 

    1970                 1975                 1980             





Arg Pro  Asp Ser Glu His Gly  Leu Ser Pro Asp Ser  Glu Asn Phe 

    1985                 1990                 1995             





Asp Trp  Lys Ala Ile Gln Glu  Gly Ala Asn Ser Ile  Val Ser Ser 

    2000                 2005                 2010             





Leu His  Gln Ala Ala Ala Ala  Ala Cys Leu Ser Arg  Gln Ala Ser 

    2015                 2020                 2025             





Ser Asp  Ser Asp Ser Ile Leu  Ser Leu Lys Ser Gly  Ile Ser Leu 

    2030                 2035                 2040             





Gly Ser  Pro Phe His Leu Thr  Pro Asp Gln Glu Glu  Lys Pro Phe 

    2045                 2050                 2055             





Thr Ser  Asn Lys Gly Pro Arg  Ile Leu Lys Pro Gly  Glu Lys Ser 

    2060                 2065                 2070             





Thr Leu  Glu Thr Lys Lys Ile  Glu Ser Glu Ser Lys  Gly Ile Lys 

    2075                 2080                 2085             





Gly Gly  Lys Lys Val Tyr Lys  Ser Leu Ile Thr Gly  Lys Val Arg 

    2090                 2095                 2100             





Ser Asn  Ser Glu Ile Ser Gly  Gln Met Lys Gln Pro  Leu Gln Ala 

    2105                 2110                 2115             





Asn Met  Pro Ser Ile Ser Arg  Gly Arg Thr Met Ile  His Ile Pro 

    2120                 2125                 2130             





Gly Val  Arg Asn Ser Ser Ser  Ser Thr Ser Pro Val  Ser Lys Lys 

    2135                 2140                 2145             





Gly Pro  Pro Leu Lys Thr Pro  Ala Ser Lys Ser Pro  Ser Glu Gly 

    2150                 2155                 2160             





Gln Thr  Ala Thr Thr Ser Pro  Arg Gly Ala Lys Pro  Ser Val Lys 

    2165                 2170                 2175             





Ser Glu  Leu Ser Pro Val Ala  Arg Gln Thr Ser Gln  Ile Gly Gly 

    2180                 2185                 2190             





Ser Ser  Lys Ala Pro Ser Arg  Ser Gly Ser Arg Asp  Ser Thr Pro 

    2195                 2200                 2205             





Ser Arg  Pro Ala Gln Gln Pro  Leu Ser Arg Pro Ile  Gln Ser Pro 

    2210                 2215                 2220             





Gly Arg  Asn Ser Ile Ser Pro  Gly Arg Asn Gly Ile  Ser Pro Pro 

    2225                 2230                 2235             





Asn Lys  Leu Ser Gln Leu Pro  Arg Thr Ser Ser Pro  Ser Thr Ala 

    2240                 2245                 2250             





Ser Thr  Lys Ser Ser Gly Ser  Gly Lys Met Ser Tyr  Thr Ser Pro 

    2255                 2260                 2265             





Gly Arg  Gln Met Ser Gln Gln  Asn Leu Thr Lys Gln  Thr Gly Leu 

    2270                 2275                 2280             





Ser Lys  Asn Ala Ser Ser Ile  Pro Arg Ser Glu Ser  Ala Ser Lys 

    2285                 2290                 2295             





Gly Leu  Asn Gln Met Asn Asn  Gly Asn Gly Ala Asn  Lys Lys Val 

    2300                 2305                 2310             





Glu Leu  Ser Arg Met Ser Ser  Thr Lys Ser Ser Gly  Ser Glu Ser 

    2315                 2320                 2325             





Asp Arg  Ser Glu Arg Pro Val  Leu Val Arg Gln Ser  Thr Phe Ile 

    2330                 2335                 2340             





Lys Glu  Ala Pro Ser Pro Thr  Leu Arg Arg Lys Leu  Glu Glu Ser 

    2345                 2350                 2355             





Ala Ser  Phe Glu Ser Leu Ser  Pro Ser Ser Arg Pro  Ala Ser Pro 

    2360                 2365                 2370             





Thr Arg  Ser Gln Ala Gln Thr  Pro Val Leu Ser Pro  Ser Leu Pro 

    2375                 2380                 2385             





Asp Met  Ser Leu Ser Thr His  Ser Ser Val Gln Ala  Gly Gly Trp 

    2390                 2395                 2400             





Arg Lys  Leu Pro Pro Asn Leu  Ser Pro Thr Ile Glu  Tyr Asn Asp 

    2405                 2410                 2415             





Gly Arg  Pro Ala Lys Arg His  Asp Ile Ala Arg Ser  His Ser Glu 

    2420                 2425                 2430             





Ser Pro  Ser Arg Leu Pro Ile  Asn Arg Ser Gly Thr  Trp Lys Arg 

    2435                 2440                 2445             





Glu His  Ser Lys His Ser Ser  Ser Leu Pro Arg Val  Ser Thr Trp 

    2450                 2455                 2460             





Arg Arg  Thr Gly Ser Ser Ser  Ser Ile Leu Ser Ala  Ser Ser Glu 

    2465                 2470                 2475             





Ser Ser  Glu Lys Ala Lys Ser  Glu Asp Glu Lys His  Val Asn Ser 

    2480                 2485                 2490             





Ile Ser  Gly Thr Lys Gln Ser  Lys Glu Asn Gln Val  Ser Ala Lys 

    2495                 2500                 2505             





Gly Thr  Trp Arg Lys Ile Lys  Glu Asn Glu Phe Ser  Pro Thr Asn 

    2510                 2515                 2520             





Ser Thr  Ser Gln Thr Val Ser  Ser Gly Ala Thr Asn  Gly Ala Glu 

    2525                 2530                 2535             





Ser Lys  Thr Leu Ile Tyr Gln  Met Ala Pro Ala Val  Ser Lys Thr 

    2540                 2545                 2550             





Glu Asp  Val Trp Val Arg Ile  Glu Asp Cys Pro Ile  Asn Asn Pro 

    2555                 2560                 2565             





Arg Ser  Gly Arg Ser Pro Thr  Gly Asn Thr Pro Pro  Val Ile Asp 

    2570                 2575                 2580             





Ser Val  Ser Glu Lys Ala Asn  Pro Asn Ile Lys Asp  Ser Lys Asp 

    2585                 2590                 2595             





Asn Gln  Ala Lys Gln Asn Val  Gly Asn Gly Ser Val  Pro Met Arg 

    2600                 2605                 2610             





Thr Val  Gly Leu Glu Asn Arg  Leu Asn Ser Phe Ile  Gln Val Asp 

    2615                 2620                 2625             





Ala Pro  Asp Gln Lys Gly Thr  Glu Ile Lys Pro Gly  Gln Asn Asn 

    2630                 2635                 2640             





Pro Val  Pro Val Ser Glu Thr  Asn Glu Ser Ser Ile  Val Glu Arg 

    2645                 2650                 2655             





Thr Pro  Phe Ser Ser Ser Ser  Ser Ser Lys His Ser  Ser Pro Ser 

    2660                 2665                 2670             





Gly Thr  Val Ala Ala Arg Val  Thr Pro Phe Asn Tyr  Asn Pro Ser 

    2675                 2680                 2685             





Pro Arg  Lys Ser Ser Ala Asp  Ser Thr Ser Ala Arg  Pro Ser Gln 

    2690                 2695                 2700             





Ile Pro  Thr Pro Val Asn Asn  Asn Thr Lys Lys Arg  Asp Ser Lys 

    2705                 2710                 2715             





Thr Asp  Ser Thr Glu Ser Ser  Gly Thr Gln Ser Pro  Lys Arg His 

    2720                 2725                 2730             





Ser Gly  Ser Tyr Leu Val Thr  Ser Val 

    2735                 2740         





<210>  240

<211>  2825

<212>  PRT

<213>  Homo sapiens



<400>  240



Met Tyr Ala Ser Leu Gly Ser Gly Pro Val Ala Pro Leu Pro Ala Ser 

1               5                   10                  15      





Val Pro Pro Ser Val Leu Gly Ser Trp Ser Thr Gly Gly Ser Arg Ser 

            20                  25                  30          





Cys Val Arg Gln Glu Thr Lys Ser Pro Gly Gly Ala Arg Thr Ser Gly 

        35                  40                  45              





His Trp Ala Ser Val Trp Gln Glu Val Leu Lys Gln Leu Gln Gly Ser 

    50                  55                  60                  





Ile Glu Asp Glu Ala Met Ala Ser Ser Gly Gln Ile Asp Leu Leu Glu 

65                  70                  75                  80  





Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser Asn Phe Pro Gly Val Lys 

                85                  90                  95      





Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr Gly Ser Arg Glu Gly Ser 

            100                 105                 110         





Val Ser Ser Arg Ser Gly Glu Cys Ser Pro Val Pro Met Gly Ser Phe 

        115                 120                 125             





Pro Arg Arg Gly Phe Val Asn Gly Ser Arg Glu Ser Thr Gly Tyr Leu 

    130                 135                 140                 





Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu Leu Ala Asp Leu Asp Lys 

145                 150                 155                 160 





Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala Gln Leu Gln Asn Leu Thr 

                165                 170                 175     





Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu Asn Phe Ser Leu Gln Thr 

            180                 185                 190         





Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu Ala Arg Gln Ile Arg Val 

        195                 200                 205             





Ala Met Glu Glu Gln Leu Gly Thr Cys Gln Asp Met Glu Lys Arg Ala 

    210                 215                 220                 





Gln Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp Ala Glu 

225                 230                 235                 240 





Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala Thr Ser 

                245                 250                 255     





Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr Ala Ser 

            260                 265                 270         





Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu Thr Ser 

        275                 280                 285             





His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser Met Leu 

    290                 295                 300                 





Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala Met Ser 

305                 310                 315                 320 





Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys Leu Pro 

                325                 330                 335     





Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val Leu Leu 

            340                 345                 350         





Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser Ala Ala 

        355                 360                 365             





Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly Arg Arg 

    370                 375                 380                 





Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr Cys Glu 

385                 390                 395                 400 





Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp Gln Asp 

                405                 410                 415     





Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro Ala Val 

            420                 425                 430         





Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His Ala Met 

        435                 440                 445             





Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln Val Asp 

    450                 455                 460                 





Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr Leu Arg 

465                 470                 475                 480 





Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp Val Ala 

                485                 490                 495     





Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala Leu Val 

            500                 505                 510         





Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile Ala Ser 

        515                 520                 525             





Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys Lys Thr 

    530                 535                 540                 





Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala Leu Glu 

545                 550                 555                 560 





Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu Trp Asn 

                565                 570                 575     





Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala Val Asp 

            580                 585                 590         





Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser Gln Thr 

        595                 600                 605             





Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg Asn Val 

    610                 615                 620                 





Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu Arg Glu 

625                 630                 635                 640 





Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His Ser Leu 

                645                 650                 655     





Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser Ala Arg 

            660                 665                 670         





Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val Ser Met 

        675                 680                 685             





Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met Gly Ser 

    690                 695                 700                 





Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys Tyr Lys 

705                 710                 715                 720 





Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu His Val 

                725                 730                 735     





Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His Leu Ser 

            740                 745                 750         





Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser His Arg 

        755                 760                 765             





Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val Phe Asp 

    770                 775                 780                 





Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr Gly Asn 

785                 790                 795                 800 





Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro Ser Ser 

                805                 810                 815     





Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys Asp Arg 

            820                 825                 830         





Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His Pro Ala 

        835                 840                 845             





Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile Ser Thr 

    850                 855                 860                 





Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala Ile His 

865                 870                 875                 880 





Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu His Cys 

                885                 890                 895     





Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala His Thr 

            900                 905                 910         





His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn Arg Thr 

        915                 920                 925             





Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser Asn Asp 

    930                 935                 940                 





Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg Gly Gln 

945                 950                 955                 960 





Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser Lys Phe 

                965                 970                 975     





Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile His Ser 

            980                 985                 990         





Ala Asn His Met Asp Asp Asn Asp  Gly Glu Leu Asp Thr  Pro Ile Asn 

        995                 1000                 1005             





Tyr Ser  Leu Lys Tyr Ser Asp  Glu Gln Leu Asn Ser  Gly Arg Gln 

    1010                 1015                 1020             





Ser Pro  Ser Gln Asn Glu Arg  Trp Ala Arg Pro Lys  His Ile Ile 

    1025                 1030                 1035             





Glu Asp  Glu Ile Lys Gln Ser  Glu Gln Arg Gln Ser  Arg Asn Gln 

    1040                 1045                 1050             





Ser Thr  Thr Tyr Pro Val Tyr  Thr Glu Ser Thr Asp  Asp Lys His 

    1055                 1060                 1065             





Leu Lys  Phe Gln Pro His Phe  Gly Gln Gln Glu Cys  Val Ser Pro 

    1070                 1075                 1080             





Tyr Arg  Ser Arg Gly Ala Asn  Gly Ser Glu Thr Asn  Arg Val Gly 

    1085                 1090                 1095             





Ser Asn  His Gly Ile Asn Gln  Asn Val Ser Gln Ser  Leu Cys Gln 

    1100                 1105                 1110             





Glu Asp  Asp Tyr Glu Asp Asp  Lys Pro Thr Asn Tyr  Ser Glu Arg 

    1115                 1120                 1125             





Tyr Ser  Glu Glu Glu Gln His  Glu Glu Glu Glu Arg  Pro Thr Asn 

    1130                 1135                 1140             





Tyr Ser  Ile Lys Tyr Asn Glu  Glu Lys Arg His Val  Asp Gln Pro 

    1145                 1150                 1155             





Ile Asp  Tyr Ser Leu Lys Tyr  Ala Thr Asp Ile Pro  Ser Ser Gln 

    1160                 1165                 1170             





Lys Gln  Ser Phe Ser Phe Ser  Lys Ser Ser Ser Gly  Gln Ser Ser 

    1175                 1180                 1185             





Lys Thr  Glu His Met Ser Ser  Ser Ser Glu Asn Thr  Ser Thr Pro 

    1190                 1195                 1200             





Ser Ser  Asn Ala Lys Arg Gln  Asn Gln Leu His Pro  Ser Ser Ala 

    1205                 1210                 1215             





Gln Ser  Arg Ser Gly Gln Pro  Gln Lys Ala Ala Thr  Cys Lys Val 

    1220                 1225                 1230             





Ser Ser  Ile Asn Gln Glu Thr  Ile Gln Thr Tyr Cys  Val Glu Asp 

    1235                 1240                 1245             





Thr Pro  Ile Cys Phe Ser Arg  Cys Ser Ser Leu Ser  Ser Leu Ser 

    1250                 1255                 1260             





Ser Ala  Glu Asp Glu Ile Gly  Cys Asn Gln Thr Thr  Gln Glu Ala 

    1265                 1270                 1275             





Asp Ser  Ala Asn Thr Leu Gln  Ile Ala Glu Ile Lys  Glu Lys Ile 

    1280                 1285                 1290             





Gly Thr  Arg Ser Ala Glu Asp  Pro Val Ser Glu Val  Pro Ala Val 

    1295                 1300                 1305             





Ser Gln  His Pro Arg Thr Lys  Ser Ser Arg Leu Gln  Gly Ser Ser 

    1310                 1315                 1320             





Leu Ser  Ser Glu Ser Ala Arg  His Lys Ala Val Glu  Phe Ser Ser 

    1325                 1330                 1335             





Gly Ala  Lys Ser Pro Ser Lys  Ser Gly Ala Gln Thr  Pro Lys Ser 

    1340                 1345                 1350             





Pro Pro  Glu His Tyr Val Gln  Glu Thr Pro Leu Met  Phe Ser Arg 

    1355                 1360                 1365             





Cys Thr  Ser Val Ser Ser Leu  Asp Ser Phe Glu Ser  Arg Ser Ile 

    1370                 1375                 1380             





Ala Ser  Ser Val Gln Ser Glu  Pro Cys Ser Gly Met  Val Ser Gly 

    1385                 1390                 1395             





Ile Ile  Ser Pro Ser Asp Leu  Pro Asp Ser Pro Gly  Gln Thr Met 

    1400                 1405                 1410             





Pro Pro  Ser Arg Ser Lys Thr  Pro Pro Pro Pro Pro  Gln Thr Ala 

    1415                 1420                 1425             





Gln Thr  Lys Arg Glu Val Pro  Lys Asn Lys Ala Pro  Thr Ala Glu 

    1430                 1435                 1440             





Lys Arg  Glu Ser Gly Pro Lys  Gln Ala Ala Val Asn  Ala Ala Val 

    1445                 1450                 1455             





Gln Arg  Val Gln Val Leu Pro  Asp Ala Asp Thr Leu  Leu His Phe 

    1460                 1465                 1470             





Ala Thr  Glu Ser Thr Pro Asp  Gly Phe Ser Cys Ser  Ser Ser Leu 

    1475                 1480                 1485             





Ser Ala  Leu Ser Leu Asp Glu  Pro Phe Ile Gln Lys  Asp Val Glu 

    1490                 1495                 1500             





Leu Arg  Ile Met Pro Pro Val  Gln Glu Asn Asp Asn  Gly Asn Glu 

    1505                 1510                 1515             





Thr Glu  Ser Glu Gln Pro Lys  Glu Ser Asn Glu Asn  Gln Glu Lys 

    1520                 1525                 1530             





Glu Ala  Glu Lys Thr Ile Asp  Ser Glu Lys Asp Leu  Leu Asp Asp 

    1535                 1540                 1545             





Ser Asp  Asp Asp Asp Ile Glu  Ile Leu Glu Glu Cys  Ile Ile Ser 

    1550                 1555                 1560             





Ala Met  Pro Thr Lys Ser Ser  Arg Lys Ala Lys Lys  Pro Ala Gln 

    1565                 1570                 1575             





Thr Ala  Ser Lys Leu Pro Pro  Pro Val Ala Arg Lys  Pro Ser Gln 

    1580                 1585                 1590             





Leu Pro  Val Tyr Lys Leu Leu  Pro Ser Gln Asn Arg  Leu Gln Pro 

    1595                 1600                 1605             





Gln Lys  His Val Ser Phe Thr  Pro Gly Asp Asp Met  Pro Arg Val 

    1610                 1615                 1620             





Tyr Cys  Val Glu Gly Thr Pro  Ile Asn Phe Ser Thr  Ala Thr Ser 

    1625                 1630                 1635             





Leu Ser  Asp Leu Thr Ile Glu  Ser Pro Pro Asn Glu  Leu Ala Ala 

    1640                 1645                 1650             





Gly Glu  Gly Val Arg Gly Gly  Ala Gln Ser Gly Glu  Phe Glu Lys 

    1655                 1660                 1665             





Arg Asp  Thr Ile Pro Thr Glu  Gly Arg Ser Thr Asp  Glu Ala Gln 

    1670                 1675                 1680             





Gly Gly  Lys Thr Ser Ser Val  Thr Ile Pro Glu Leu  Asp Asp Asn 

    1685                 1690                 1695             





Lys Ala  Glu Glu Gly Asp Ile  Leu Ala Glu Cys Ile  Asn Ser Ala 

    1700                 1705                 1710             





Met Pro  Lys Gly Lys Ser His  Lys Pro Phe Arg Val  Lys Lys Ile 

    1715                 1720                 1725             





Met Asp  Gln Val Gln Gln Ala  Ser Ala Ser Ser Ser  Ala Pro Asn 

    1730                 1735                 1740             





Lys Asn  Gln Leu Asp Gly Lys  Lys Lys Lys Pro Thr  Ser Pro Val 

    1745                 1750                 1755             





Lys Pro  Ile Pro Gln Asn Thr  Glu Tyr Arg Thr Arg  Val Arg Lys 

    1760                 1765                 1770             





Asn Ala  Asp Ser Lys Asn Asn  Leu Asn Ala Glu Arg  Val Phe Ser 

    1775                 1780                 1785             





Asp Asn  Lys Asp Ser Lys Lys  Gln Asn Leu Lys Asn  Asn Ser Lys 

    1790                 1795                 1800             





Val Phe  Asn Asp Lys Leu Pro  Asn Asn Glu Asp Arg  Val Arg Gly 

    1805                 1810                 1815             





Ser Phe  Ala Phe Asp Ser Pro  His His Tyr Thr Pro  Ile Glu Gly 

    1820                 1825                 1830             





Thr Pro  Tyr Cys Phe Ser Arg  Asn Asp Ser Leu Ser  Ser Leu Asp 

    1835                 1840                 1845             





Phe Asp  Asp Asp Asp Val Asp  Leu Ser Arg Glu Lys  Ala Glu Leu 

    1850                 1855                 1860             





Arg Lys  Ala Lys Glu Asn Lys  Glu Ser Glu Ala Lys  Val Thr Ser 

    1865                 1870                 1875             





His Thr  Glu Leu Thr Ser Asn  Gln Gln Ser Ala Asn  Lys Thr Gln 

    1880                 1885                 1890             





Ala Ile  Ala Lys Gln Pro Ile  Asn Arg Gly Gln Pro  Lys Pro Ile 

    1895                 1900                 1905             





Leu Gln  Lys Gln Ser Thr Phe  Pro Gln Ser Ser Lys  Asp Ile Pro 

    1910                 1915                 1920             





Asp Arg  Gly Ala Ala Thr Asp  Glu Lys Leu Gln Asn  Phe Ala Ile 

    1925                 1930                 1935             





Glu Asn  Thr Pro Val Cys Phe  Ser His Asn Ser Ser  Leu Ser Ser 

    1940                 1945                 1950             





Leu Ser  Asp Ile Asp Gln Glu  Asn Asn Asn Lys Glu  Asn Glu Pro 

    1955                 1960                 1965             





Ile Lys  Glu Thr Glu Pro Pro  Asp Ser Gln Gly Glu  Pro Ser Lys 

    1970                 1975                 1980             





Pro Gln  Ala Ser Gly Tyr Ala  Pro Lys Ser Phe His  Val Glu Asp 

    1985                 1990                 1995             





Thr Pro  Val Cys Phe Ser Arg  Asn Ser Ser Leu Ser  Ser Leu Ser 

    2000                 2005                 2010             





Ile Asp  Ser Glu Asp Asp Leu  Leu Gln Glu Cys Ile  Ser Ser Ala 

    2015                 2020                 2025             





Met Pro  Lys Lys Lys Lys Pro  Ser Arg Leu Lys Gly  Asp Asn Glu 

    2030                 2035                 2040             





Lys His  Ser Pro Arg Asn Met  Gly Gly Ile Leu Gly  Glu Asp Leu 

    2045                 2050                 2055             





Thr Leu  Asp Leu Lys Asp Ile  Gln Arg Pro Asp Ser  Glu His Gly 

    2060                 2065                 2070             





Leu Ser  Pro Asp Ser Glu Asn  Phe Asp Trp Lys Ala  Ile Gln Glu 

    2075                 2080                 2085             





Gly Ala  Asn Ser Ile Val Ser  Ser Leu His Gln Ala  Ala Ala Ala 

    2090                 2095                 2100             





Ala Cys  Leu Ser Arg Gln Ala  Ser Ser Asp Ser Asp  Ser Ile Leu 

    2105                 2110                 2115             





Ser Leu  Lys Ser Gly Ile Ser  Leu Gly Ser Pro Phe  His Leu Thr 

    2120                 2125                 2130             





Pro Asp  Gln Glu Glu Lys Pro  Phe Thr Ser Asn Lys  Gly Pro Arg 

    2135                 2140                 2145             





Ile Leu  Lys Pro Gly Glu Lys  Ser Thr Leu Glu Thr  Lys Lys Ile 

    2150                 2155                 2160             





Glu Ser  Glu Ser Lys Gly Ile  Lys Gly Gly Lys Lys  Val Tyr Lys 

    2165                 2170                 2175             





Ser Leu  Ile Thr Gly Lys Val  Arg Ser Asn Ser Glu  Ile Ser Gly 

    2180                 2185                 2190             





Gln Met  Lys Gln Pro Leu Gln  Ala Asn Met Pro Ser  Ile Ser Arg 

    2195                 2200                 2205             





Gly Arg  Thr Met Ile His Ile  Pro Gly Val Arg Asn  Ser Ser Ser 

    2210                 2215                 2220             





Ser Thr  Ser Pro Val Ser Lys  Lys Gly Pro Pro Leu  Lys Thr Pro 

    2225                 2230                 2235             





Ala Ser  Lys Ser Pro Ser Glu  Gly Gln Thr Ala Thr  Thr Ser Pro 

    2240                 2245                 2250             





Arg Gly  Ala Lys Pro Ser Val  Lys Ser Glu Leu Ser  Pro Val Ala 

    2255                 2260                 2265             





Arg Gln  Thr Ser Gln Ile Gly  Gly Ser Ser Lys Ala  Pro Ser Arg 

    2270                 2275                 2280             





Ser Gly  Ser Arg Asp Ser Thr  Pro Ser Arg Pro Ala  Gln Gln Pro 

    2285                 2290                 2295             





Leu Ser  Arg Pro Ile Gln Ser  Pro Gly Arg Asn Ser  Ile Ser Pro 

    2300                 2305                 2310             





Gly Arg  Asn Gly Ile Ser Pro  Pro Asn Lys Leu Ser  Gln Leu Pro 

    2315                 2320                 2325             





Arg Thr  Ser Ser Pro Ser Thr  Ala Ser Thr Lys Ser  Ser Gly Ser 

    2330                 2335                 2340             





Gly Lys  Met Ser Tyr Thr Ser  Pro Gly Arg Gln Met  Ser Gln Gln 

    2345                 2350                 2355             





Asn Leu  Thr Lys Gln Thr Gly  Leu Ser Lys Asn Ala  Ser Ser Ile 

    2360                 2365                 2370             





Pro Arg  Ser Glu Ser Ala Ser  Lys Gly Leu Asn Gln  Met Asn Asn 

    2375                 2380                 2385             





Gly Asn  Gly Ala Asn Lys Lys  Val Glu Leu Ser Arg  Met Ser Ser 

    2390                 2395                 2400             





Thr Lys  Ser Ser Gly Ser Glu  Ser Asp Arg Ser Glu  Arg Pro Val 

    2405                 2410                 2415             





Leu Val  Arg Gln Ser Thr Phe  Ile Lys Glu Ala Pro  Ser Pro Thr 

    2420                 2425                 2430             





Leu Arg  Arg Lys Leu Glu Glu  Ser Ala Ser Phe Glu  Ser Leu Ser 

    2435                 2440                 2445             





Pro Ser  Ser Arg Pro Ala Ser  Pro Thr Arg Ser Gln  Ala Gln Thr 

    2450                 2455                 2460             





Pro Val  Leu Ser Pro Ser Leu  Pro Asp Met Ser Leu  Ser Thr His 

    2465                 2470                 2475             





Ser Ser  Val Gln Ala Gly Gly  Trp Arg Lys Leu Pro  Pro Asn Leu 

    2480                 2485                 2490             





Ser Pro  Thr Ile Glu Tyr Asn  Asp Gly Arg Pro Ala  Lys Arg His 

    2495                 2500                 2505             





Asp Ile  Ala Arg Ser His Ser  Glu Ser Pro Ser Arg  Leu Pro Ile 

    2510                 2515                 2520             





Asn Arg  Ser Gly Thr Trp Lys  Arg Glu His Ser Lys  His Ser Ser 

    2525                 2530                 2535             





Ser Leu  Pro Arg Val Ser Thr  Trp Arg Arg Thr Gly  Ser Ser Ser 

    2540                 2545                 2550             





Ser Ile  Leu Ser Ala Ser Ser  Glu Ser Ser Glu Lys  Ala Lys Ser 

    2555                 2560                 2565             





Glu Asp  Glu Lys His Val Asn  Ser Ile Ser Gly Thr  Lys Gln Ser 

    2570                 2575                 2580             





Lys Glu  Asn Gln Val Ser Ala  Lys Gly Thr Trp Arg  Lys Ile Lys 

    2585                 2590                 2595             





Glu Asn  Glu Phe Ser Pro Thr  Asn Ser Thr Ser Gln  Thr Val Ser 

    2600                 2605                 2610             





Ser Gly  Ala Thr Asn Gly Ala  Glu Ser Lys Thr Leu  Ile Tyr Gln 

    2615                 2620                 2625             





Met Ala  Pro Ala Val Ser Lys  Thr Glu Asp Val Trp  Val Arg Ile 

    2630                 2635                 2640             





Glu Asp  Cys Pro Ile Asn Asn  Pro Arg Ser Gly Arg  Ser Pro Thr 

    2645                 2650                 2655             





Gly Asn  Thr Pro Pro Val Ile  Asp Ser Val Ser Glu  Lys Ala Asn 

    2660                 2665                 2670             





Pro Asn  Ile Lys Asp Ser Lys  Asp Asn Gln Ala Lys  Gln Asn Val 

    2675                 2680                 2685             





Gly Asn  Gly Ser Val Pro Met  Arg Thr Val Gly Leu  Glu Asn Arg 

    2690                 2695                 2700             





Leu Asn  Ser Phe Ile Gln Val  Asp Ala Pro Asp Gln  Lys Gly Thr 

    2705                 2710                 2715             





Glu Ile  Lys Pro Gly Gln Asn  Asn Pro Val Pro Val  Ser Glu Thr 

    2720                 2725                 2730             





Asn Glu  Ser Ser Ile Val Glu  Arg Thr Pro Phe Ser  Ser Ser Ser 

    2735                 2740                 2745             





Ser Ser  Lys His Ser Ser Pro  Ser Gly Thr Val Ala  Ala Arg Val 

    2750                 2755                 2760             





Thr Pro  Phe Asn Tyr Asn Pro  Ser Pro Arg Lys Ser  Ser Ala Asp 

    2765                 2770                 2775             





Ser Thr  Ser Ala Arg Pro Ser  Gln Ile Pro Thr Pro  Val Asn Asn 

    2780                 2785                 2790             





Asn Thr  Lys Lys Arg Asp Ser  Lys Thr Asp Ser Thr  Glu Ser Ser 

    2795                 2800                 2805             





Gly Thr  Gln Ser Pro Lys Arg  His Ser Gly Ser Tyr  Leu Val Thr 

    2810                 2815                 2820             





Ser Val  

    2825 





<210>  241

<211>  743

<212>  PRT

<213>  Homo sapiens



<400>  241



Met Asn Asn Pro Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp 

1               5                   10                  15      





Gly Asn Thr Gly Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro 

            20                  25                  30          





Val Pro Val Gly Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu 

        35                  40                  45              





Gly His Leu His Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala 

    50                  55                  60                  





Ala Gln Ser Leu Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp 

65                  70                  75                  80  





Ser Gln Gln Pro Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala 

                85                  90                  95      





Ile Pro Gln Thr Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu 

            100                 105                 110         





Thr Leu Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala 

        115                 120                 125             





Gln Ala Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln 

    130                 135                 140                 





Gln His Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro 

145                 150                 155                 160 





Met Thr Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu 

                165                 170                 175     





Gln Gln Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe 

            180                 185                 190         





Val Leu Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile 

        195                 200                 205             





Ser Gln Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu 

    210                 215                 220                 





Leu Thr Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln 

225                 230                 235                 240 





Pro Ser Ile Thr Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile 

                245                 250                 255     





Ala Ala Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys 

            260                 265                 270         





Arg Ile Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu 

        275                 280                 285             





Glu Gln Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 

    290                 295                 300                 





Thr Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp 

305                 310                 315                 320 





Phe Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe 

                325                 330                 335     





Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp 

            340                 345                 350         





Ala Glu Asn Leu Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu 

        355                 360                 365             





Asn Ser Pro Gly Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr 

    370                 375                 380                 





Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu 

385                 390                 395                 400 





Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu 

                405                 410                 415     





Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln 

            420                 425                 430         





Lys Glu Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser 

        435                 440                 445             





Pro Ile Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr 

    450                 455                 460                 





Pro Ser Leu Val Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro 

465                 470                 475                 480 





Val Leu Pro Leu Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly 

                485                 490                 495     





Thr Ser Asp Thr Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala 

            500                 505                 510         





Pro Pro Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro 

        515                 520                 525             





Ser Ala Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser 

    530                 535                 540                 





Thr Thr Gln Thr Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser 

545                 550                 555                 560 





Gln Val Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala 

                565                 570                 575     





Leu Gln Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met 

            580                 585                 590         





Ala Ala Ala Ala Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe 

        595                 600                 605             





Ala Ala Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly 

    610                 615                 620                 





Ala Leu Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln 

625                 630                 635                 640 





Ala Leu Ala Ser Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr 

                645                 650                 655     





Gly Asn Leu Val Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr 

            660                 665                 670         





Ala Pro Leu Phe Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn 

        675                 680                 685             





Pro Val Ser Leu Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala 

    690                 695                 700                 





Pro Val Ala Ser Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln 

705                 710                 715                 720 





Asn Ser Leu Phe Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr 

                725                 730                 735     





Thr Thr Ala Ser Lys Ala Gln 

            740             





<210>  242

<211>  755

<212>  PRT

<213>  Homo sapiens



<400>  242



Met Leu Asp Cys Ser Asp Tyr Val Leu Asp Ser Arg Met Asn Asn Pro 

1               5                   10                  15      





Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp Gly Asn Thr Gly 

            20                  25                  30          





Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro Val Pro Val Gly 

        35                  40                  45              





Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu Gly His Leu His 

    50                  55                  60                  





Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala Ala Gln Ser Leu 

65                  70                  75                  80  





Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp Ser Gln Gln Pro 

                85                  90                  95      





Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala Ile Pro Gln Thr 

            100                 105                 110         





Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu Thr Leu Thr Pro 

        115                 120                 125             





Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala Gln Ala Gln Leu 

    130                 135                 140                 





Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln Gln His Ser Ala 

145                 150                 155                 160 





Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro Met Thr Gln Ile 

                165                 170                 175     





Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu Gln Gln Leu Gln 

            180                 185                 190         





Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe Val Leu Val His 

        195                 200                 205             





Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile Ser Gln Thr Pro 

    210                 215                 220                 





Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu Leu Thr Gln Leu 

225                 230                 235                 240 





Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln Pro Ser Ile Thr 

                245                 250                 255     





Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile Ala Ala Thr Pro 

            260                 265                 270         





Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys Arg Ile Asp Thr 

        275                 280                 285             





Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala 

    290                 295                 300                 





Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp 

305                 310                 315                 320 





Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr 

                325                 330                 335     





Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys 

            340                 345                 350         





Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Asn Leu 

        355                 360                 365             





Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu Asn Ser Pro Gly 

    370                 375                 380                 





Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr 

385                 390                 395                 400 





Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro 

                405                 410                 415     





Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys 

            420                 425                 430         





Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg 

        435                 440                 445             





Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser Pro Ile Lys Ala 

    450                 455                 460                 





Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr Pro Ser Leu Val 

465                 470                 475                 480 





Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro Val Leu Pro Leu 

                485                 490                 495     





Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly Thr Ser Asp Thr 

            500                 505                 510         





Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala Pro Pro Ala Ser 

        515                 520                 525             





Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro Ser Ala Ser Ala 

    530                 535                 540                 





Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser Thr Thr Gln Thr 

545                 550                 555                 560 





Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser Gln Val Met Val 

                565                 570                 575     





Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala Leu Gln Gly Ala 

            580                 585                 590         





Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met Ala Ala Ala Ala 

        595                 600                 605             





Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe Ala Ala Gly Gly 

    610                 615                 620                 





Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly Ala Leu Ser Pro 

625                 630                 635                 640 





Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln Ala Leu Ala Ser 

                645                 650                 655     





Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr Gly Asn Leu Val 

            660                 665                 670         





Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr Ala Pro Leu Phe 

        675                 680                 685             





Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn Pro Val Ser Leu 

    690                 695                 700                 





Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala Pro Val Ala Ser 

705                 710                 715                 720 





Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln Asn Ser Leu Phe 

                725                 730                 735     





Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr Thr Thr Ala Ser 

            740                 745                 750         





Lys Ala Gln 

        755 





<210>  243

<211>  741

<212>  PRT

<213>  Homo sapiens



<400>  243



Met Lys Thr Arg Met Lys Ile Phe Val Met Ile His Phe His Leu Met 

1               5                   10                  15      





Asn Ser Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro Val Pro 

            20                  25                  30          





Val Gly Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu Gly His 

        35                  40                  45              





Leu His Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala Ala Gln 

    50                  55                  60                  





Ser Leu Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp Ser Gln 

65                  70                  75                  80  





Gln Pro Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala Ile Pro 

                85                  90                  95      





Gln Thr Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu Thr Leu 

            100                 105                 110         





Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala Gln Ala 

        115                 120                 125             





Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln Gln His 

    130                 135                 140                 





Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro Met Thr 

145                 150                 155                 160 





Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu Gln Gln 

                165                 170                 175     





Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe Val Leu 

            180                 185                 190         





Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile Ser Gln 

        195                 200                 205             





Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu Leu Thr 

    210                 215                 220                 





Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln Pro Ser 

225                 230                 235                 240 





Ile Thr Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile Ala Ala 

                245                 250                 255     





Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys Arg Ile 

            260                 265                 270         





Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln 

        275                 280                 285             





Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln 

    290                 295                 300                 





Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser 

305                 310                 315                 320 





Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn 

                325                 330                 335     





Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu 

            340                 345                 350         





Asn Leu Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu Asn Ser 

        355                 360                 365             





Pro Gly Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr Ser Ile 

    370                 375                 380                 





Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln 

385                 390                 395                 400 





Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met 

                405                 410                 415     





Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu 

            420                 425                 430         





Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser Pro Ile 

        435                 440                 445             





Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr Pro Ser 

    450                 455                 460                 





Leu Val Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro Val Leu 

465                 470                 475                 480 





Pro Leu Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly Thr Ser 

                485                 490                 495     





Asp Thr Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala Pro Pro 

            500                 505                 510         





Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro Ser Ala 

        515                 520                 525             





Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser Thr Thr 

    530                 535                 540                 





Gln Thr Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser Gln Val 

545                 550                 555                 560 





Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala Leu Gln 

                565                 570                 575     





Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met Ala Ala 

            580                 585                 590         





Ala Ala Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe Ala Ala 

        595                 600                 605             





Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly Ala Leu 

    610                 615                 620                 





Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln Ala Leu 

625                 630                 635                 640 





Ala Ser Gly Gly Ser Leu Pro Ile Thr Ser Leu Asp Ala Thr Gly Asn 

                645                 650                 655     





Leu Val Phe Ala Asn Ala Gly Gly Ala Pro Asn Ile Val Thr Ala Pro 

            660                 665                 670         





Leu Phe Leu Asn Pro Gln Asn Leu Ser Leu Leu Thr Ser Asn Pro Val 

        675                 680                 685             





Ser Leu Val Ser Ala Ala Ala Ala Ser Ala Gly Asn Ser Ala Pro Val 

    690                 695                 700                 





Ala Ser Leu His Ala Thr Ser Thr Ser Ala Glu Ser Ile Gln Asn Ser 

705                 710                 715                 720 





Leu Phe Thr Val Ala Ser Ala Ser Gly Ala Ala Ser Thr Thr Thr Thr 

                725                 730                 735     





Ala Ser Lys Ala Gln 

            740     





<210>  244

<211>  766

<212>  PRT

<213>  Homo sapiens



<400>  244



Met Ala Asp Gly Gly Ala Ala Ser Gln Asp Glu Ser Ser Ala Ala Ala 

1               5                   10                  15      





Ala Ala Ala Ala Asp Ser Arg Met Asn Asn Pro Ser Glu Thr Ser Lys 

            20                  25                  30          





Pro Ser Met Glu Ser Gly Asp Gly Asn Thr Gly Thr Gln Thr Asn Gly 

        35                  40                  45              





Leu Asp Phe Gln Lys Gln Pro Val Pro Val Gly Gly Ala Ile Ser Thr 

    50                  55                  60                  





Ala Gln Ala Gln Ala Phe Leu Gly His Leu His Gln Val Gln Leu Ala 

65                  70                  75                  80  





Gly Thr Ser Leu Gln Ala Ala Ala Gln Ser Leu Asn Val Gln Ser Lys 

                85                  90                  95      





Ser Asn Glu Glu Ser Gly Asp Ser Gln Gln Pro Ser Gln Pro Ser Gln 

            100                 105                 110         





Gln Pro Ser Val Gln Ala Ala Ile Pro Gln Thr Gln Leu Met Leu Ala 

        115                 120                 125             





Gly Gly Gln Ile Thr Gly Leu Thr Leu Thr Pro Ala Gln Gln Gln Leu 

    130                 135                 140                 





Leu Leu Gln Gln Ala Gln Ala Gln Ala Gln Leu Leu Ala Ala Ala Val 

145                 150                 155                 160 





Gln Gln His Ser Ala Ser Gln Gln His Ser Ala Ala Gly Ala Thr Ile 

                165                 170                 175     





Ser Ala Ser Ala Ala Thr Pro Met Thr Gln Ile Pro Leu Ser Gln Pro 

            180                 185                 190         





Ile Gln Ile Ala Gln Asp Leu Gln Gln Leu Gln Gln Leu Gln Gln Gln 

        195                 200                 205             





Asn Leu Asn Leu Gln Gln Phe Val Leu Val His Pro Thr Thr Asn Leu 

    210                 215                 220                 





Gln Pro Ala Gln Phe Ile Ile Ser Gln Thr Pro Gln Gly Gln Gln Gly 

225                 230                 235                 240 





Leu Leu Gln Ala Gln Asn Leu Leu Thr Gln Leu Pro Gln Gln Ser Gln 

                245                 250                 255     





Ala Asn Leu Leu Gln Ser Gln Pro Ser Ile Thr Leu Thr Ser Gln Pro 

            260                 265                 270         





Ala Thr Pro Thr Arg Thr Ile Ala Ala Thr Pro Ile Gln Thr Leu Pro 

        275                 280                 285             





Gln Ser Gln Ser Thr Pro Lys Arg Ile Asp Thr Pro Ser Leu Glu Glu 

    290                 295                 300                 





Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala Lys Thr Phe Lys Gln 

305                 310                 315                 320 





Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp Val Gly Leu Ala Met 

                325                 330                 335     





Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr Thr Ile Ser Arg Phe 

            340                 345                 350         





Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys Lys Leu Lys Pro Leu 

        355                 360                 365             





Leu Glu Lys Trp Leu Asn Asp Ala Glu Asn Leu Ser Ser Asp Ser Ser 

    370                 375                 380                 





Leu Ser Ser Pro Ser Ala Leu Asn Ser Pro Gly Ile Glu Gly Leu Ser 

385                 390                 395                 400 





Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala 

                405                 410                 415     





Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile 

            420                 425                 430         





Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val 

        435                 440                 445             





Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn Pro Pro Ser 

    450                 455                 460                 





Ser Gly Gly Thr Ser Ser Ser Pro Ile Lys Ala Ile Phe Pro Ser Pro 

465                 470                 475                 480 





Thr Ser Leu Val Ala Thr Thr Pro Ser Leu Val Thr Ser Ser Ala Ala 

                485                 490                 495     





Thr Thr Leu Thr Val Ser Pro Val Leu Pro Leu Thr Ser Ala Ala Val 

            500                 505                 510         





Thr Asn Leu Ser Val Thr Gly Thr Ser Asp Thr Thr Ser Asn Asn Thr 

        515                 520                 525             





Ala Thr Val Ile Ser Thr Ala Pro Pro Ala Ser Ser Ala Val Thr Ser 

    530                 535                 540                 





Pro Ser Leu Ser Pro Ser Pro Ser Ala Ser Ala Ser Thr Ser Glu Ala 

545                 550                 555                 560 





Ser Ser Ala Ser Glu Thr Ser Thr Thr Gln Thr Thr Ser Thr Pro Leu 

                565                 570                 575     





Ser Ser Pro Leu Gly Thr Ser Gln Val Met Val Thr Ala Ser Gly Leu 

            580                 585                 590         





Gln Thr Ala Ala Ala Ala Ala Leu Gln Gly Ala Ala Gln Leu Pro Ala 

        595                 600                 605             





Asn Ala Ser Leu Ala Ala Met Ala Ala Ala Ala Gly Leu Asn Pro Ser 

    610                 615                 620                 





Leu Met Ala Pro Ser Gln Phe Ala Ala Gly Gly Ala Leu Leu Ser Leu 

625                 630                 635                 640 





Asn Pro Gly Thr Leu Ser Gly Ala Leu Ser Pro Ala Leu Met Ser Asn 

                645                 650                 655     





Ser Thr Leu Ala Thr Ile Gln Ala Leu Ala Ser Gly Gly Ser Leu Pro 

            660                 665                 670         





Ile Thr Ser Leu Asp Ala Thr Gly Asn Leu Val Phe Ala Asn Ala Gly 

        675                 680                 685             





Gly Ala Pro Asn Ile Val Thr Ala Pro Leu Phe Leu Asn Pro Gln Asn 

    690                 695                 700                 





Leu Ser Leu Leu Thr Ser Asn Pro Val Ser Leu Val Ser Ala Ala Ala 

705                 710                 715                 720 





Ala Ser Ala Gly Asn Ser Ala Pro Val Ala Ser Leu His Ala Thr Ser 

                725                 730                 735     





Thr Ser Ala Glu Ser Ile Gln Asn Ser Leu Phe Thr Val Ala Ser Ala 

            740                 745                 750         





Ser Gly Ala Ala Ser Thr Thr Thr Thr Ala Ser Lys Ala Gln 

        755                 760                 765     





<210>  245

<211>  653

<212>  PRT

<213>  Homo sapiens



<400>  245



Met Asn Asn Pro Ser Glu Thr Ser Lys Pro Ser Met Glu Ser Gly Asp 

1               5                   10                  15      





Gly Asn Thr Gly Thr Gln Thr Asn Gly Leu Asp Phe Gln Lys Gln Pro 

            20                  25                  30          





Val Pro Val Gly Gly Ala Ile Ser Thr Ala Gln Ala Gln Ala Phe Leu 

        35                  40                  45              





Gly His Leu His Gln Val Gln Leu Ala Gly Thr Ser Leu Gln Ala Ala 

    50                  55                  60                  





Ala Gln Ser Leu Asn Val Gln Ser Lys Ser Asn Glu Glu Ser Gly Asp 

65                  70                  75                  80  





Ser Gln Gln Pro Ser Gln Pro Ser Gln Gln Pro Ser Val Gln Ala Ala 

                85                  90                  95      





Ile Pro Gln Thr Gln Leu Met Leu Ala Gly Gly Gln Ile Thr Gly Leu 

            100                 105                 110         





Thr Leu Thr Pro Ala Gln Gln Gln Leu Leu Leu Gln Gln Ala Gln Ala 

        115                 120                 125             





Gln Ala Gln Leu Leu Ala Ala Ala Val Gln Gln His Ser Ala Ser Gln 

    130                 135                 140                 





Gln His Ser Ala Ala Gly Ala Thr Ile Ser Ala Ser Ala Ala Thr Pro 

145                 150                 155                 160 





Met Thr Gln Ile Pro Leu Ser Gln Pro Ile Gln Ile Ala Gln Asp Leu 

                165                 170                 175     





Gln Gln Leu Gln Gln Leu Gln Gln Gln Asn Leu Asn Leu Gln Gln Phe 

            180                 185                 190         





Val Leu Val His Pro Thr Thr Asn Leu Gln Pro Ala Gln Phe Ile Ile 

        195                 200                 205             





Ser Gln Thr Pro Gln Gly Gln Gln Gly Leu Leu Gln Ala Gln Asn Leu 

    210                 215                 220                 





Leu Thr Gln Leu Pro Gln Gln Ser Gln Ala Asn Leu Leu Gln Ser Gln 

225                 230                 235                 240 





Pro Ser Ile Thr Leu Thr Ser Gln Pro Ala Thr Pro Thr Arg Thr Ile 

                245                 250                 255     





Ala Ala Thr Pro Ile Gln Thr Leu Pro Gln Ser Gln Ser Thr Pro Lys 

            260                 265                 270         





Arg Ile Asp Thr Pro Ser Leu Glu Glu Pro Ser Asp Leu Glu Glu Leu 

        275                 280                 285             





Glu Gln Phe Ala Lys Thr Phe Lys Gln Arg Arg Ile Lys Leu Gly Phe 

    290                 295                 300                 





Thr Gln Gly Asp Val Gly Leu Ala Met Gly Lys Leu Tyr Gly Asn Asp 

305                 310                 315                 320 





Phe Ser Gln Thr Thr Ile Ser Arg Phe Glu Ala Leu Asn Leu Ser Phe 

                325                 330                 335     





Lys Asn Met Cys Lys Leu Lys Pro Leu Leu Glu Lys Trp Leu Asn Asp 

            340                 345                 350         





Ala Glu Asn Leu Ser Ser Asp Ser Ser Leu Ser Ser Pro Ser Ala Leu 

        355                 360                 365             





Asn Ser Pro Gly Ile Glu Gly Leu Ser Arg Arg Arg Lys Lys Arg Thr 

    370                 375                 380                 





Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu 

385                 390                 395                 400 





Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu 

                405                 410                 415     





Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln 

            420                 425                 430         





Lys Glu Lys Arg Ile Asn Pro Pro Ser Ser Gly Gly Thr Ser Ser Ser 

        435                 440                 445             





Pro Ile Lys Ala Ile Phe Pro Ser Pro Thr Ser Leu Val Ala Thr Thr 

    450                 455                 460                 





Pro Ser Leu Val Thr Ser Ser Ala Ala Thr Thr Leu Thr Val Ser Pro 

465                 470                 475                 480 





Val Leu Pro Leu Thr Ser Ala Ala Val Thr Asn Leu Ser Val Thr Gly 

                485                 490                 495     





Thr Ser Asp Thr Thr Ser Asn Asn Thr Ala Thr Val Ile Ser Thr Ala 

            500                 505                 510         





Pro Pro Ala Ser Ser Ala Val Thr Ser Pro Ser Leu Ser Pro Ser Pro 

        515                 520                 525             





Ser Ala Ser Ala Ser Thr Ser Glu Ala Ser Ser Ala Ser Glu Thr Ser 

    530                 535                 540                 





Thr Thr Gln Thr Thr Ser Thr Pro Leu Ser Ser Pro Leu Gly Thr Ser 

545                 550                 555                 560 





Gln Val Met Val Thr Ala Ser Gly Leu Gln Thr Ala Ala Ala Ala Ala 

                565                 570                 575     





Leu Gln Gly Ala Ala Gln Leu Pro Ala Asn Ala Ser Leu Ala Ala Met 

            580                 585                 590         





Ala Ala Ala Ala Gly Leu Asn Pro Ser Leu Met Ala Pro Ser Gln Phe 

        595                 600                 605             





Ala Ala Gly Gly Ala Leu Leu Ser Leu Asn Pro Gly Thr Leu Ser Gly 

    610                 615                 620                 





Ala Leu Ser Pro Ala Leu Met Ser Asn Ser Thr Leu Ala Thr Ile Gln 

625                 630                 635                 640 





Gly Leu Leu His Gly Leu Glu Asn Phe Leu Thr Lys Asn 

                645                 650             





<210>  246

<211>  703

<212>  PRT

<213>  Homo sapiens



<400>  246



Met Ala Asp Gly Gly Ala Ala Ser Gln Asp Glu Ser Ser Ala Ala Ala 

1               5                   10                  15      





Ala Ala Ala Ala Asp Ser Arg Met Asn Asn Pro Ser Glu Thr Ser Lys 

            20                  25                  30          





Pro Ser Met Glu Ser Gly Asp Gly Asn Thr Gly Thr Gln Thr Asn Gly 

        35                  40                  45              





Leu Asp Phe Gln Lys Gln Pro Val Pro Val Gly Gly Ala Ile Ser Thr 

    50                  55                  60                  





Ala Gln Ala Gln Ala Phe Leu Gly His Leu His Gln Val Gln Leu Ala 

65                  70                  75                  80  





Gly Thr Ser Leu Gln Ala Ala Ala Gln Ser Leu Asn Val Gln Ser Lys 

                85                  90                  95      





Ser Asn Glu Glu Ser Gly Asp Ser Gln Gln Pro Ser Gln Pro Ser Gln 

            100                 105                 110         





Gln Pro Ser Val Gln Ala Ala Ile Pro Gln Thr Gln Leu Met Leu Ala 

        115                 120                 125             





Gly Gly Gln Ile Thr Gly Asp Leu Gln Gln Leu Gln Gln Leu Gln Gln 

    130                 135                 140                 





Gln Asn Leu Asn Leu Gln Gln Phe Val Leu Val His Pro Thr Thr Asn 

145                 150                 155                 160 





Leu Gln Pro Ala Gln Phe Ile Ile Ser Gln Thr Pro Gln Gly Gln Gln 

                165                 170                 175     





Gly Leu Leu Gln Ala Gln Asn Leu Leu Thr Gln Leu Pro Gln Gln Ser 

            180                 185                 190         





Gln Ala Asn Leu Leu Gln Ser Gln Pro Ser Ile Thr Leu Thr Ser Gln 

        195                 200                 205             





Pro Ala Thr Pro Thr Arg Thr Ile Ala Ala Thr Pro Ile Gln Thr Leu 

    210                 215                 220                 





Pro Gln Ser Gln Ser Thr Pro Lys Arg Ile Asp Thr Pro Ser Leu Glu 

225                 230                 235                 240 





Glu Pro Ser Asp Leu Glu Glu Leu Glu Gln Phe Ala Lys Thr Phe Lys 

                245                 250                 255     





Gln Arg Arg Ile Lys Leu Gly Phe Thr Gln Gly Asp Val Gly Leu Ala 

            260                 265                 270         





Met Gly Lys Leu Tyr Gly Asn Asp Phe Ser Gln Thr Thr Ile Ser Arg 

        275                 280                 285             





Phe Glu Ala Leu Asn Leu Ser Phe Lys Asn Met Cys Lys Leu Lys Pro 

    290                 295                 300                 





Leu Leu Glu Lys Trp Leu Asn Asp Ala Glu Asn Leu Ser Ser Asp Ser 

305                 310                 315                 320 





Ser Leu Ser Ser Pro Ser Ala Leu Asn Ser Pro Gly Ile Glu Gly Leu 

                325                 330                 335     





Ser Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val 

            340                 345                 350         





Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu 

        355                 360                 365             





Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg 

    370                 375                 380                 





Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn Pro Pro 

385                 390                 395                 400 





Ser Ser Gly Gly Thr Ser Ser Ser Pro Ile Lys Ala Ile Phe Pro Ser 

                405                 410                 415     





Pro Thr Ser Leu Val Ala Thr Thr Pro Ser Leu Val Thr Ser Ser Ala 

            420                 425                 430         





Ala Thr Thr Leu Thr Val Ser Pro Val Leu Pro Leu Thr Ser Ala Ala 

        435                 440                 445             





Val Thr Asn Leu Ser Val Thr Gly Thr Ser Asp Thr Thr Ser Asn Asn 

    450                 455                 460                 





Thr Ala Thr Val Ile Ser Thr Ala Pro Pro Ala Ser Ser Ala Val Thr 

465                 470                 475                 480 





Ser Pro Ser Leu Ser Pro Ser Pro Ser Ala Ser Ala Ser Thr Ser Glu 

                485                 490                 495     





Ala Ser Ser Ala Ser Glu Thr Ser Thr Thr Gln Thr Thr Ser Thr Pro 

            500                 505                 510         





Leu Ser Ser Pro Leu Gly Thr Ser Gln Val Met Val Thr Ala Ser Gly 

        515                 520                 525             





Leu Gln Thr Ala Ala Ala Ala Ala Leu Gln Gly Ala Ala Gln Leu Pro 

    530                 535                 540                 





Ala Asn Ala Ser Leu Ala Ala Met Ala Ala Ala Ala Gly Leu Asn Pro 

545                 550                 555                 560 





Ser Leu Met Ala Pro Ser Gln Phe Ala Ala Gly Gly Ala Leu Leu Ser 

                565                 570                 575     





Leu Asn Pro Gly Thr Leu Ser Gly Ala Leu Ser Pro Ala Leu Met Ser 

            580                 585                 590         





Asn Ser Thr Leu Ala Thr Ile Gln Ala Leu Ala Ser Gly Gly Ser Leu 

        595                 600                 605             





Pro Ile Thr Ser Leu Asp Ala Thr Gly Asn Leu Val Phe Ala Asn Ala 

    610                 615                 620                 





Gly Gly Ala Pro Asn Ile Val Thr Ala Pro Leu Phe Leu Asn Pro Gln 

625                 630                 635                 640 





Asn Leu Ser Leu Leu Thr Ser Asn Pro Val Ser Leu Val Ser Ala Ala 

                645                 650                 655     





Ala Ala Ser Ala Gly Asn Ser Ala Pro Val Ala Ser Leu His Ala Thr 

            660                 665                 670         





Ser Thr Ser Ala Glu Ser Ile Gln Asn Ser Leu Phe Thr Val Ala Ser 

        675                 680                 685             





Ala Ser Gly Ala Ala Ser Thr Thr Thr Thr Ala Ser Lys Ala Gln 

    690                 695                 700             





<210>  247

<211>  388

<212>  PRT

<213>  Homo sapiens



<400>  247



Met Ser Ala Pro Ser Thr Leu Pro Pro Gly Gly Glu Glu Gly Leu Gly 

1               5                   10                  15      





Thr Ala Trp Pro Ser Ala Ala Asn Ala Ser Ser Ala Pro Ala Glu Ala 

            20                  25                  30          





Glu Glu Ala Val Ala Gly Pro Gly Asp Ala Arg Ala Ala Gly Met Val 

        35                  40                  45              





Ala Ile Gln Cys Ile Tyr Ala Leu Val Cys Leu Val Gly Leu Val Gly 

    50                  55                  60                  





Asn Ala Leu Val Ile Phe Val Ile Leu Arg Tyr Ala Lys Met Lys Thr 

65                  70                  75                  80  





Ala Thr Asn Ile Tyr Leu Leu Asn Leu Ala Val Ala Asp Glu Leu Phe 

                85                  90                  95      





Met Leu Ser Val Pro Phe Val Ala Ser Ser Ala Ala Leu Arg His Trp 

            100                 105                 110         





Pro Phe Gly Ser Val Leu Cys Arg Ala Val Leu Ser Val Asp Gly Leu 

        115                 120                 125             





Asn Met Phe Thr Ser Val Phe Cys Leu Thr Val Leu Ser Val Asp Arg 

    130                 135                 140                 





Tyr Val Ala Val Val His Pro Leu Arg Ala Ala Thr Tyr Arg Arg Pro 

145                 150                 155                 160 





Ser Val Ala Lys Leu Ile Asn Leu Gly Val Trp Leu Ala Ser Leu Leu 

                165                 170                 175     





Val Thr Leu Pro Ile Ala Ile Phe Ala Asp Thr Arg Pro Ala Arg Gly 

            180                 185                 190         





Gly Gln Ala Val Ala Cys Asn Leu Gln Trp Pro His Pro Ala Trp Ser 

        195                 200                 205             





Ala Val Phe Val Val Tyr Thr Phe Leu Leu Gly Phe Leu Leu Pro Val 

    210                 215                 220                 





Leu Ala Ile Gly Leu Cys Tyr Leu Leu Ile Val Gly Lys Met Arg Ala 

225                 230                 235                 240 





Val Ala Leu Arg Ala Gly Trp Gln Gln Arg Arg Arg Ser Glu Lys Lys 

                245                 250                 255     





Ile Thr Arg Leu Val Leu Met Val Val Val Val Phe Val Leu Cys Trp 

            260                 265                 270         





Met Pro Phe Tyr Val Val Gln Leu Leu Asn Leu Phe Val Thr Ser Leu 

        275                 280                 285             





Asp Ala Thr Val Asn His Val Ser Leu Ile Leu Ser Tyr Ala Asn Ser 

    290                 295                 300                 





Cys Ala Asn Pro Ile Leu Tyr Gly Phe Leu Ser Asp Asn Phe Arg Arg 

305                 310                 315                 320 





Phe Phe Gln Arg Val Leu Cys Leu Arg Cys Cys Leu Leu Glu Gly Ala 

                325                 330                 335     





Gly Gly Ala Glu Glu Glu Pro Leu Asp Tyr Tyr Ala Thr Ala Leu Lys 

            340                 345                 350         





Ser Lys Gly Gly Ala Gly Cys Met Cys Pro Pro Leu Pro Cys Gln Gln 

        355                 360                 365             





Glu Ala Leu Gln Pro Glu Pro Gly Arg Lys Arg Ile Pro Leu Thr Arg 

    370                 375                 380                 





Thr Thr Thr Phe 

385             





<210>  248

<211>  790

<212>  PRT

<213>  Homo sapiens



<400>  248



Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 

1               5                   10                  15      





Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 

            20                  25                  30          





Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 

        35                  40                  45              





Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 

    50                  55                  60                  





His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 

65                  70                  75                  80  





Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 

                85                  90                  95      





Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 

            100                 105                 110         





Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 

        115                 120                 125             





Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 

    130                 135                 140                 





Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 

145                 150                 155                 160 





Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 

                165                 170                 175     





Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 

            180                 185                 190         





Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 

        195                 200                 205             





Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 

    210                 215                 220                 





Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 

225                 230                 235                 240 





Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 

                245                 250                 255     





Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 

            260                 265                 270         





Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 

        275                 280                 285             





His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 

    290                 295                 300                 





Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 

305                 310                 315                 320 





Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 

                325                 330                 335     





Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 

            340                 345                 350         





Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 

        355                 360                 365             





Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 

    370                 375                 380                 





Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 

385                 390                 395                 400 





Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 

                405                 410                 415     





Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 

            420                 425                 430         





Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 

        435                 440                 445             





Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 

    450                 455                 460                 





Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 

465                 470                 475                 480 





Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 

                485                 490                 495     





Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 

            500                 505                 510         





Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 

        515                 520                 525             





Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 

    530                 535                 540                 





Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 

545                 550                 555                 560 





Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 

                565                 570                 575     





His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 

            580                 585                 590         





Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 

        595                 600                 605             





Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 

    610                 615                 620                 





Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 

625                 630                 635                 640 





Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 

                645                 650                 655     





Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 

            660                 665                 670         





Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 

        675                 680                 685             





Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 

    690                 695                 700                 





Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 

705                 710                 715                 720 





Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 

                725                 730                 735     





Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 

            740                 745                 750         





Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 

        755                 760                 765             





His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 

    770                 775                 780                 





Phe Lys Gln Met Tyr Gly 

785                 790 





<210>  249

<211>  498

<212>  PRT

<213>  Homo sapiens



<400>  249



Met Asp Phe Ser Val Lys Val Asp Ile Glu Lys Glu Val Thr Cys Pro 

1               5                   10                  15      





Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 

            20                  25                  30          





Ser Phe Cys Gln Ala Cys Ile Thr Ala Lys Ile Lys Glu Ser Val Ile 

        35                  40                  45              





Ile Ser Arg Gly Glu Ser Ser Cys Pro Val Cys Gln Thr Arg Phe Gln 

    50                  55                  60                  





Pro Gly Asn Leu Arg Pro Asn Arg His Leu Ala Asn Ile Val Glu Arg 

65                  70                  75                  80  





Val Lys Glu Val Lys Met Ser Pro Gln Glu Gly Gln Lys Arg Asp Val 

                85                  90                  95      





Cys Glu His His Gly Lys Lys Leu Gln Ile Phe Cys Lys Glu Asp Gly 

            100                 105                 110         





Lys Val Ile Cys Trp Val Cys Glu Leu Ser Gln Glu His Gln Gly His 

        115                 120                 125             





Gln Thr Phe Arg Ile Asn Glu Val Val Lys Glu Cys Gln Glu Lys Leu 

    130                 135                 140                 





Gln Val Ala Leu Gln Arg Leu Ile Lys Glu Asp Gln Glu Ala Glu Lys 

145                 150                 155                 160 





Leu Glu Asp Asp Ile Arg Gln Glu Arg Thr Ala Trp Lys Asn Tyr Ile 

                165                 170                 175     





Gln Ile Glu Arg Gln Lys Ile Leu Lys Gly Phe Asn Glu Met Arg Val 

            180                 185                 190         





Ile Leu Asp Asn Glu Glu Gln Arg Glu Leu Gln Lys Leu Glu Glu Gly 

        195                 200                 205             





Glu Val Asn Val Leu Asp Asn Leu Ala Ala Ala Thr Asp Gln Leu Val 

    210                 215                 220                 





Gln Gln Arg Gln Asp Ala Ser Thr Leu Ile Ser Asp Leu Gln Arg Arg 

225                 230                 235                 240 





Leu Arg Gly Ser Ser Val Glu Met Leu Gln Asp Val Ile Asp Val Met 

                245                 250                 255     





Lys Arg Ser Glu Ser Trp Thr Leu Lys Lys Pro Lys Ser Val Ser Lys 

            260                 265                 270         





Lys Leu Lys Ser Val Phe Arg Val Pro Asp Leu Ser Gly Met Leu Gln 

        275                 280                 285             





Val Leu Lys Glu Leu Thr Asp Val Gln Tyr Tyr Trp Val Asp Val Met 

    290                 295                 300                 





Leu Asn Pro Gly Ser Ala Thr Ser Asn Val Ala Ile Ser Val Asp Gln 

305                 310                 315                 320 





Arg Gln Val Lys Thr Val Arg Thr Cys Thr Phe Lys Asn Ser Asn Pro 

                325                 330                 335     





Cys Asp Phe Ser Ala Phe Gly Val Phe Gly Cys Gln Tyr Phe Ser Ser 

            340                 345                 350         





Gly Lys Tyr Tyr Trp Glu Val Asp Val Ser Gly Lys Ile Ala Trp Ile 

        355                 360                 365             





Leu Gly Val His Ser Lys Ile Ser Ser Leu Asn Lys Arg Lys Ser Ser 

    370                 375                 380                 





Gly Phe Ala Phe Asp Pro Ser Val Asn Tyr Ser Lys Val Tyr Ser Arg 

385                 390                 395                 400 





Tyr Arg Pro Gln Tyr Gly Tyr Trp Val Ile Gly Leu Gln Asn Thr Cys 

                405                 410                 415     





Glu Tyr Asn Ala Phe Glu Asp Ser Ser Ser Ser Asp Pro Lys Val Leu 

            420                 425                 430         





Thr Leu Phe Met Ala Val Pro Pro Cys Arg Ile Gly Val Phe Leu Asp 

        435                 440                 445             





Tyr Glu Ala Gly Ile Val Ser Phe Phe Asn Val Thr Asn His Gly Ala 

    450                 455                 460                 





Leu Ile Tyr Lys Phe Ser Gly Cys Arg Phe Ser Arg Pro Ala Tyr Pro 

465                 470                 475                 480 





Tyr Phe Asn Pro Trp Asn Cys Leu Val Pro Met Thr Val Cys Pro Pro 

                485                 490                 495     





Ser Ser 

        





<210>  250

<211>  494

<212>  PRT

<213>  Homo sapiens



<400>  250



Met Asp Phe Ser Val Lys Val Asp Ile Glu Lys Glu Val Thr Cys Pro 

1               5                   10                  15      





Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 

            20                  25                  30          





Ser Phe Cys Gln Ala Cys Ile Thr Ala Lys Ile Lys Glu Ser Val Ile 

        35                  40                  45              





Ile Ser Arg Gly Glu Ser Ser Cys Pro Val Cys Gln Thr Arg Phe Gln 

    50                  55                  60                  





Pro Gly Asn Leu Arg Pro Asn Arg His Leu Ala Asn Ile Val Glu Arg 

65                  70                  75                  80  





Val Lys Glu Val Lys Met Ser Pro Gln Glu Gly Gln Lys Arg Asp Val 

                85                  90                  95      





Cys Glu His His Gly Lys Lys Leu Gln Ile Phe Cys Lys Glu Asp Gly 

            100                 105                 110         





Lys Val Ile Cys Trp Val Cys Glu Leu Ser Gln Glu His Gln Gly His 

        115                 120                 125             





Gln Thr Phe Arg Ile Asn Glu Val Val Lys Glu Cys Gln Glu Lys Leu 

    130                 135                 140                 





Gln Val Ala Leu Gln Arg Leu Ile Lys Glu Asp Gln Glu Ala Glu Lys 

145                 150                 155                 160 





Leu Glu Asp Asp Ile Arg Gln Glu Arg Thr Ala Trp Lys Ile Glu Arg 

                165                 170                 175     





Gln Lys Ile Leu Lys Gly Phe Asn Glu Met Arg Val Ile Leu Asp Asn 

            180                 185                 190         





Glu Glu Gln Arg Glu Leu Gln Lys Leu Glu Glu Gly Glu Val Asn Val 

        195                 200                 205             





Leu Asp Asn Leu Ala Ala Ala Thr Asp Gln Leu Val Gln Gln Arg Gln 

    210                 215                 220                 





Asp Ala Ser Thr Leu Ile Ser Asp Leu Gln Arg Arg Leu Arg Gly Ser 

225                 230                 235                 240 





Ser Val Glu Met Leu Gln Asp Val Ile Asp Val Met Lys Arg Ser Glu 

                245                 250                 255     





Ser Trp Thr Leu Lys Lys Pro Lys Ser Val Ser Lys Lys Leu Lys Ser 

            260                 265                 270         





Val Phe Arg Val Pro Asp Leu Ser Gly Met Leu Gln Val Leu Lys Glu 

        275                 280                 285             





Leu Thr Asp Val Gln Tyr Tyr Trp Val Asp Val Met Leu Asn Pro Gly 

    290                 295                 300                 





Ser Ala Thr Ser Asn Val Ala Ile Ser Val Asp Gln Arg Gln Val Lys 

305                 310                 315                 320 





Thr Val Arg Thr Cys Thr Phe Lys Asn Ser Asn Pro Cys Asp Phe Ser 

                325                 330                 335     





Ala Phe Gly Val Phe Gly Cys Gln Tyr Phe Ser Ser Gly Lys Tyr Tyr 

            340                 345                 350         





Trp Glu Val Asp Val Ser Gly Lys Ile Ala Trp Ile Leu Gly Val His 

        355                 360                 365             





Ser Lys Ile Ser Ser Leu Asn Lys Arg Lys Ser Ser Gly Phe Ala Phe 

    370                 375                 380                 





Asp Pro Ser Val Asn Tyr Ser Lys Val Tyr Ser Arg Tyr Arg Pro Gln 

385                 390                 395                 400 





Tyr Gly Tyr Trp Val Ile Gly Leu Gln Asn Thr Cys Glu Tyr Asn Ala 

                405                 410                 415     





Phe Glu Asp Ser Ser Ser Ser Asp Pro Lys Val Leu Thr Leu Phe Met 

            420                 425                 430         





Ala Val Pro Pro Cys Arg Ile Gly Val Phe Leu Asp Tyr Glu Ala Gly 

        435                 440                 445             





Ile Val Ser Phe Phe Asn Val Thr Asn His Gly Ala Leu Ile Tyr Lys 

    450                 455                 460                 





Phe Ser Gly Cys Arg Phe Ser Arg Pro Ala Tyr Pro Tyr Phe Asn Pro 

465                 470                 475                 480 





Trp Asn Cys Leu Val Pro Met Thr Val Cys Pro Pro Ser Ser 

                485                 490                 





<210>  251

<211>  233

<212>  PRT

<213>  Homo sapiens



<400>  251



Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 

1               5                   10                  15      





Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 

            20                  25                  30          





Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 

        35                  40                  45              





Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 

    50                  55                  60                  





Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 

65                  70                  75                  80  





Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 

                85                  90                  95      





Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 

            100                 105                 110         





Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 

        115                 120                 125             





Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 

    130                 135                 140                 





Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 

145                 150                 155                 160 





Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 

                165                 170                 175     





Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 

            180                 185                 190         





Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 

        195                 200                 205             





Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 

    210                 215                 220                 





Gln Val Tyr Phe Gly Ile Ile Ala Leu 

225                 230             





<210>  252

<211>  205

<212>  PRT

<213>  Homo sapiens



<400>  252



Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 

1               5                   10                  15      





Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 

            20                  25                  30          





Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 

        35                  40                  45              





Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 

    50                  55                  60                  





Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 

65                  70                  75                  80  





Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 

                85                  90                  95      





Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 

            100                 105                 110         





Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 

        115                 120                 125             





Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 

    130                 135                 140                 





His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 

145                 150                 155                 160 





Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 

                165                 170                 175     





Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 

            180                 185                 190         





Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 

        195                 200                 205 





<210>  253

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  253



Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 

1               5                   10                  15      





Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 

            20                  25                  30          





Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 

        35                  40                  45              





His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 

    50                  55                  60                  





Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 

65                  70                  75                  80  





Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 

                85                  90                  95      





Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 

            100                 105                 110         





His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 

        115                 120                 125             





Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 

    130                 135                 140                 





Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 

145                 150                 155                 160 





Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 

                165                 170                 175     





Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 

            180                 185                 190         





Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 

        195                 200                 205             





Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 

    210                 215                 220                 





Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 

225                 230                 235                 240 





Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 

                245                 250             





<210>  254

<211>  228

<212>  PRT

<213>  Homo sapiens



<400>  254



Ile Leu Gly Gly Arg Glu Ala Glu Ala His Ala Arg Pro Tyr Met Ala 

1               5                   10                  15      





Ser Val Gln Leu Asn Gly Ala His Leu Cys Gly Gly Val Leu Val Ala 

            20                  25                  30          





Glu Gln Trp Val Leu Ser Ala Ala His Cys Leu Glu Asp Ala Ala Asp 

        35                  40                  45              





Gly Lys Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Gln Pro Glu 

    50                  55                  60                  





Pro Ser Lys Arg Leu Tyr Asp Val Leu Arg Ala Val Pro His Pro Asp 

65                  70                  75                  80  





Ser Gln Pro Asp Thr Ile Asp His Asp Leu Leu Leu Leu Gln Leu Ser 

                85                  90                  95      





Glu Lys Ala Thr Leu Gly Pro Ala Val Arg Pro Leu Pro Trp Gln Arg 

            100                 105                 110         





Val Asp Arg Asp Val Ala Pro Gly Thr Leu Cys Asp Val Ala Gly Trp 

        115                 120                 125             





Gly Ile Val Asn His Ala Gly Arg Arg Pro Asp Ser Leu Gln His Val 

    130                 135                 140                 





Leu Leu Pro Val Leu Asp Arg Ala Thr Cys Asn Arg Arg Thr His His 

145                 150                 155                 160 





Asp Gly Ala Ile Thr Glu Arg Leu Met Cys Ala Glu Ser Asn Arg Arg 

                165                 170                 175     





Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly Val 

            180                 185                 190         





Leu Glu Gly Val Val Thr Ser Gly Ser Arg Val Cys Gly Asn Arg Lys 

        195                 200                 205             





Lys Pro Gly Ile Tyr Thr Arg Val Ala Ser Tyr Ala Ala Trp Ile Asp 

    210                 215                 220                 





Ser Val Leu Ala 

225             





<210>  255

<211>  260

<212>  PRT

<213>  Homo sapiens



<400>  255



Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 

1               5                   10                  15      





Ala Cys Gly Glu Glu Ala Trp Ala Trp Ala Ala Pro Pro Arg Gly Arg 

            20                  25                  30          





Ile Leu Gly Gly Arg Glu Ala Glu Ala His Ala Arg Pro Tyr Met Ala 

        35                  40                  45              





Ser Val Gln Leu Asn Gly Ala His Leu Cys Gly Gly Val Leu Val Ala 

    50                  55                  60                  





Glu Gln Trp Val Leu Ser Ala Ala His Cys Leu Glu Asp Ala Ala Asp 

65                  70                  75                  80  





Gly Lys Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Gln Pro Glu 

                85                  90                  95      





Pro Ser Lys Arg Leu Tyr Asp Val Leu Arg Ala Val Pro His Pro Asp 

            100                 105                 110         





Ser Gln Pro Asp Thr Ile Asp His Asp Leu Leu Leu Leu Gln Leu Ser 

        115                 120                 125             





Glu Lys Ala Thr Leu Gly Pro Ala Val Arg Pro Leu Pro Trp Gln Arg 

    130                 135                 140                 





Val Asp Arg Asp Val Ala Pro Gly Thr Leu Cys Asp Val Ala Gly Trp 

145                 150                 155                 160 





Gly Ile Val Asn His Ala Gly Arg Arg Pro Asp Ser Leu Gln His Val 

                165                 170                 175     





Leu Leu Pro Val Leu Asp Arg Ala Thr Cys Asn Arg Arg Thr His His 

            180                 185                 190         





Asp Gly Ala Ile Thr Glu Arg Leu Met Cys Ala Glu Ser Asn Arg Arg 

        195                 200                 205             





Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly Val 

    210                 215                 220                 





Leu Glu Gly Val Val Thr Ser Gly Ser Arg Val Cys Gly Asn Arg Lys 

225                 230                 235                 240 





Lys Pro Gly Ile Tyr Thr Arg Val Ala Ser Tyr Ala Ala Trp Ile Asp 

                245                 250                 255     





Ser Val Leu Ala 

            260 





<210>  256

<211>  210

<212>  PRT

<213>  Homo sapiens



<400>  256



Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 

1               5                   10                  15      





Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 

            20                  25                  30          





Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 

        35                  40                  45              





Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 

    50                  55                  60                  





Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 

65                  70                  75                  80  





Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 

                85                  90                  95      





Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 

            100                 105                 110         





Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 

        115                 120                 125             





Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 

    130                 135                 140                 





Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 

145                 150                 155                 160 





Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 

                165                 170                 175     





Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 

            180                 185                 190         





Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 

        195                 200                 205             





Arg Ala 

    210 





<210>  257

<211>  130

<212>  PRT

<213>  Homo sapiens



<400>  257



Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 

1               5                   10                  15      





Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 

            20                  25                  30          





Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 

        35                  40                  45              





Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 

    50                  55                  60                  





Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 

65                  70                  75                  80  





Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 

                85                  90                  95      





Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 

            100                 105                 110         





Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 

        115                 120                 125             





Arg Ala 

    130 





<210>  258

<211>  143

<212>  PRT

<213>  Homo sapiens



<400>  258



Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 

1               5                   10                  15      





Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 

            20                  25                  30          





Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 

        35                  40                  45              





Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 

    50                  55                  60                  





Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 

65                  70                  75                  80  





Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 

                85                  90                  95      





Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 

            100                 105                 110         





Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 

        115                 120                 125             





Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala 

    130                 135                 140             





<210>  259

<211>  259

<212>  PRT

<213>  Homo sapiens



<400>  259



Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 

1               5                   10                  15      





Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 

            20                  25                  30          





Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 

        35                  40                  45              





Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 

    50                  55                  60                  





Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 

65                  70                  75                  80  





Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 

                85                  90                  95      





Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 

            100                 105                 110         





Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 

        115                 120                 125             





Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 

    130                 135                 140                 





Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 

145                 150                 155                 160 





Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 

                165                 170                 175     





Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 

            180                 185                 190         





Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 

        195                 200                 205             





Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 

    210                 215                 220                 





Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 

225                 230                 235                 240 





Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 

                245                 250                 255     





Val Gln Asn 

            





<210>  260

<211>  234

<212>  PRT

<213>  Homo sapiens



<400>  260



Ala Pro Trp Gln Cys Ala Pro Cys Ser Ala Glu Lys Leu Ala Leu Cys 

1               5                   10                  15      





Pro Pro Val Ser Ala Ser Cys Ser Glu Val Thr Arg Ser Ala Gly Cys 

            20                  25                  30          





Gly Cys Cys Pro Met Cys Ala Leu Pro Leu Gly Ala Ala Cys Gly Val 

        35                  40                  45              





Ala Thr Ala Arg Cys Ala Arg Gly Leu Ser Cys Arg Ala Leu Pro Gly 

    50                  55                  60                  





Glu Gln Gln Pro Leu His Ala Leu Thr Arg Gly Gln Gly Ala Cys Val 

65                  70                  75                  80  





Gln Glu Ser Asp Ala Ser Ala Pro His Ala Ala Glu Ala Gly Ser Pro 

                85                  90                  95      





Glu Ser Pro Glu Ser Thr Glu Ile Thr Glu Glu Glu Leu Leu Asp Asn 

            100                 105                 110         





Phe His Leu Met Ala Pro Ser Glu Glu Asp His Ser Ile Leu Trp Asp 

        115                 120                 125             





Ala Ile Ser Thr Tyr Asp Gly Ser Lys Ala Leu His Val Thr Asn Ile 

    130                 135                 140                 





Lys Lys Trp Lys Glu Pro Cys Arg Ile Glu Leu Tyr Arg Val Val Glu 

145                 150                 155                 160 





Ser Leu Ala Lys Ala Gln Glu Thr Ser Gly Glu Glu Ile Ser Lys Phe 

                165                 170                 175     





Tyr Leu Pro Asn Cys Asn Lys Asn Gly Phe Tyr His Ser Arg Gln Cys 

            180                 185                 190         





Glu Thr Ser Met Asp Gly Glu Ala Gly Leu Cys Trp Cys Val Tyr Pro 

        195                 200                 205             





Trp Asn Gly Lys Arg Ile Pro Gly Ser Pro Glu Ile Arg Gly Asp Pro 

    210                 215                 220                 





Asn Cys Gln Ile Tyr Phe Asn Val Gln Asn 

225                 230                 





<210>  261

<211>  216

<212>  PRT

<213>  Homo sapiens



<400>  261



Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 

1               5                   10                  15      





Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 

            20                  25                  30          





Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 

        35                  40                  45              





Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 

    50                  55                  60                  





Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 

65                  70                  75                  80  





Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 

                85                  90                  95      





Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 

            100                 105                 110         





Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 

        115                 120                 125             





Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 

    130                 135                 140                 





Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 

145                 150                 155                 160 





Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Cys Glu Thr 

                165                 170                 175     





Ser Met Asp Gly Glu Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn 

            180                 185                 190         





Gly Lys Arg Ile Pro Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys 

        195                 200                 205             





Gln Ile Tyr Phe Asn Val Gln Asn 

    210                 215     





<210>  262

<211>  257

<212>  PRT

<213>  Homo sapiens



<400>  262



Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 

1               5                   10                  15      





Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 

            20                  25                  30          





Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 

        35                  40                  45              





Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 

    50                  55                  60                  





Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 

65                  70                  75                  80  





Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 

                85                  90                  95      





Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 

            100                 105                 110         





Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 

        115                 120                 125             





Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 

    130                 135                 140                 





Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 

145                 150                 155                 160 





Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 

                165                 170                 175     





Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 

            180                 185                 190         





Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 

        195                 200                 205             





Asn Gly Phe Tyr His Ser Arg Gln Thr Ser Met Asp Gly Glu Ala Gly 

    210                 215                 220                 





Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro Gly Ser 

225                 230                 235                 240 





Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn Val Gln 

                245                 250                 255     





Asn 

    





<210>  263

<211>  98

<212>  PRT

<213>  Homo sapiens



<400>  263



Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 

1               5                   10                  15      





Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 

            20                  25                  30          





Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 

        35                  40                  45              





Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 

    50                  55                  60                  





Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 

65                  70                  75                  80  





Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 

                85                  90                  95      





Tyr Phe 

        





<210>  264

<211>  54

<212>  PRT

<213>  Homo sapiens





<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  Xaa can be any naturally occurring amino acid



<400>  264



Xaa Ala Thr Ala Glu Thr Gln His Ile Ala Asp Gln Val His Val Gly 

1               5                   10                  15      





Asp Glu Asp Phe Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu 

            20                  25                  30          





Asn Lys Pro Leu Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His 

        35                  40                  45              





Asp Glu Leu Thr Tyr Phe 

    50                  





<210>  265

<211>  83

<212>  PRT

<213>  Homo sapiens



<400>  265



Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 

1               5                   10                  15      





Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 

            20                  25                  30          





Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 

        35                  40                  45              





Ala Gly Thr Asn Tyr Phe Ile Lys Val Glu Cys Gly Pro Gln Glu Gly 

    50                  55                  60                  





Leu Pro Arg Thr Gly Ala Gly Arg Lys Pro Pro Val Gln Ala Arg Ala 

65                  70                  75                  80  





Val Trp Ser 

            





<210>  266

<211>  194

<212>  PRT

<213>  Homo sapiens



<400>  266



Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 

1               5                   10                  15      





Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 

            20                  25                  30          





Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 

        35                  40                  45              





Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 

    50                  55                  60                  





Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 

65                  70                  75                  80  





Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 

                85                  90                  95      





Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 

            100                 105                 110         





Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 

        115                 120                 125             





Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 

    130                 135                 140                 





Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 

145                 150                 155                 160 





Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala Thr Leu 

                165                 170                 175     





Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro Gln Gln 

            180                 185                 190         





Gln Gly 

        





<210>  267

<211>  164

<212>  PRT

<213>  Homo sapiens



<400>  267



Thr Pro Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser 

1               5                   10                  15      





Thr Lys Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys 

            20                  25                  30          





Gln Cys Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu 

        35                  40                  45              





Asn Gly Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn 

    50                  55                  60                  





Phe Ser Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu 

65                  70                  75                  80  





Pro Gly Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr 

                85                  90                  95      





Gly Thr Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala 

            100                 105                 110         





Leu His Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val 

        115                 120                 125             





Val Gln Arg His Val Val Leu Ala Gln Leu Trp Ala Gly Leu Arg Ala 

    130                 135                 140                 





Thr Leu Pro Pro Thr Gln Glu Ala Leu Pro Ser Ser His Ser Ser Pro 

145                 150                 155                 160 





Gln Gln Gln Gly 

                





<210>  268

<211>  115

<212>  PRT

<213>  Homo sapiens



<400>  268



Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 

1               5                   10                  15      





Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 

            20                  25                  30          





Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 

        35                  40                  45              





Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 

    50                  55                  60                  





Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Ser Trp 

65                  70                  75                  80  





Ala Glu Gly Asn Leu Ala Pro His Pro Arg Ser Pro Ala Leu Gln Pro 

                85                  90                  95      





Gln Gln Ser Thr Ala Ala Gly Leu Arg Leu Ser Thr Gly Pro Ala Ala 

            100                 105                 110         





Ala Gln Pro 

        115 





<210>  269

<211>  163

<212>  PRT

<213>  Homo sapiens



<400>  269



Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 

1               5                   10                  15      





Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 

            20                  25                  30          





Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 

        35                  40                  45              





Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 

    50                  55                  60                  





Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 

65                  70                  75                  80  





Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 

                85                  90                  95      





Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 

            100                 105                 110         





Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Trp 

        115                 120                 125             





Ala Glu Gly Asn Leu Ala Pro His Pro Arg Ser Pro Ala Leu Gln Pro 

    130                 135                 140                 





Gln Gln Ser Thr Ala Ala Gly Leu Arg Leu Ser Thr Gly Pro Ala Ala 

145                 150                 155                 160 





Ala Gln Pro 

            





<210>  270

<211>  199

<212>  PRT

<213>  Homo sapiens



<400>  270



Met Thr Met Arg His Asn Trp Thr Pro Asp Leu Ser Pro Leu Trp Val 

1               5                   10                  15      





Leu Leu Leu Cys Ala His Val Val Thr Leu Leu Val Arg Ala Thr Pro 

            20                  25                  30          





Val Ser Gln Thr Thr Thr Ala Ala Thr Ala Ser Val Arg Ser Thr Lys 

        35                  40                  45              





Asp Pro Cys Pro Ser Gln Pro Pro Val Phe Pro Ala Ala Lys Gln Cys 

    50                  55                  60                  





Pro Ala Leu Glu Val Thr Trp Pro Glu Val Glu Val Pro Leu Asn Gly 

65                  70                  75                  80  





Thr Leu Ser Leu Ser Cys Val Ala Cys Ser Arg Phe Pro Asn Phe Ser 

                85                  90                  95      





Ile Leu Tyr Trp Leu Gly Asn Gly Ser Phe Ile Glu His Leu Pro Gly 

            100                 105                 110         





Arg Leu Trp Glu Gly Ser Thr Ser Arg Glu Arg Gly Ser Thr Gly Thr 

        115                 120                 125             





Gln Leu Cys Lys Ala Leu Val Leu Glu Gln Leu Thr Pro Ala Leu His 

    130                 135                 140                 





Ser Thr Asn Phe Ser Cys Val Leu Val Asp Pro Glu Gln Val Val Gln 

145                 150                 155                 160 





Arg His Val Val Leu Ala Gln Leu Trp Val Arg Ser Pro Arg Arg Gly 

                165                 170                 175     





Leu Gln Glu Gln Glu Glu Leu Cys Phe His Met Trp Gly Gly Lys Gly 

            180                 185                 190         





Gly Leu Cys Gln Ser Ser Leu 

        195                 





<210>  271

<211>  124

<212>  PRT

<213>  Homo sapiens



<400>  271



Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 

1               5                   10                  15      





Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 

            20                  25                  30          





Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 

        35                  40                  45              





Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 

    50                  55                  60                  





Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys 

65                  70                  75                  80  





Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 

                85                  90                  95      





Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 

            100                 105                 110         





Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 

        115                 120                 





<210>  272

<211>  94

<212>  PRT

<213>  Homo sapiens



<400>  272



Glu Lys Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr 

1               5                   10                  15      





Gln Glu Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys 

            20                  25                  30          





Ser Ala Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly 

        35                  40                  45              





Ser Cys Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg 

    50                  55                  60                  





Asp Gln Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys 

65                  70                  75                  80  





Arg Asn Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 

                85                  90                  





<210>  273

<211>  73

<212>  PRT

<213>  Homo sapiens



<400>  273



Met Leu Gln Val Gln Val Asn Leu Pro Val Ser Pro Leu Pro Thr Tyr 

1               5                   10                  15      





Pro Tyr Ser Phe Phe Tyr Pro Asp Lys Glu Gly Ser Cys Pro Gln Val 

            20                  25                  30          





Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln Cys Gln Val 

        35                  40                  45              





Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn Gly Cys Gly 

    50                  55                  60                  





Lys Val Ser Cys Val Thr Pro Asn Phe 

65                  70              





<210>  274

<211>  76

<212>  PRT

<213>  Homo sapiens



<400>  274



Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 

1               5                   10                  15      





Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Asp Lys Glu Gly Ser Cys 

            20                  25                  30          





Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 

        35                  40                  45              





Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 

    50                  55                  60                  





Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 

65                  70                  75      





<210>  275

<211>  80

<212>  PRT

<213>  Homo sapiens



<400>  275



Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 

1               5                   10                  15      





Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 

            20                  25                  30          





Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 

        35                  40                  45              





Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 

    50                  55                  60                  





Gly Cys Ala Thr Phe Cys Leu Leu Cys Pro Asn Gly Gln Leu Ala Glu 

65                  70                  75                  80  





<210>  276

<211>  102

<212>  PRT

<213>  Homo sapiens



<400>  276



Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 

1               5                   10                  15      





Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 

            20                  25                  30          





Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 

        35                  40                  45              





Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 

    50                  55                  60                  





Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Ala Leu Phe His Trp His 

65                  70                  75                  80  





Leu Lys Thr Arg Arg Leu Trp Glu Ile Ser Gly Pro Arg Pro Arg Arg 

                85                  90                  95      





Pro Thr Trp Asp Ser Ser 

            100         





<210>  277

<211>  406

<212>  PRT

<213>  Homo sapiens



<400>  277



Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 

1               5                   10                  15      





Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 

            20                  25                  30          





Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 

        35                  40                  45              





Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 

    50                  55                  60                  





Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 

65                  70                  75                  80  





Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 

                85                  90                  95      





Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 

            100                 105                 110         





Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 

        115                 120                 125             





Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 

    130                 135                 140                 





Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 

145                 150                 155                 160 





Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 

                165                 170                 175     





Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 

            180                 185                 190         





Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 

        195                 200                 205             





Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 

    210                 215                 220                 





Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 

225                 230                 235                 240 





Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 

                245                 250                 255     





Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 

            260                 265                 270         





Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 

        275                 280                 285             





Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 

    290                 295                 300                 





Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 

305                 310                 315                 320 





Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 

                325                 330                 335     





His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 

            340                 345                 350         





Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 

        355                 360                 365             





Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 

    370                 375                 380                 





Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 

385                 390                 395                 400 





Lys Thr Ile Ala Glu Asn 

                405     





<210>  278

<211>  388

<212>  PRT

<213>  Homo sapiens



<400>  278



Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys Pro 

1               5                   10                  15      





Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr 

            20                  25                  30          





Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr 

        35                  40                  45              





Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys 

    50                  55                  60                  





Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu Ile 

65                  70                  75                  80  





Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn Tyr 

                85                  90                  95      





Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asn Glu 

            100                 105                 110         





Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys Glu 

        115                 120                 125             





Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln Arg Ile 

    130                 135                 140                 





Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln Ala Lys 

145                 150                 155                 160 





Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile Asn Glu 

                165                 170                 175     





Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His Ser Glu 

            180                 185                 190         





Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val Gly 

        195                 200                 205             





Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro Asn Tyr 

    210                 215                 220                 





Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Ser Val 

225                 230                 235                 240 





Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr Ala Glu 

                245                 250                 255     





Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala Asn Phe 

            260                 265                 270         





Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala Asp Gln 

        275                 280                 285             





Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu Lys Lys 

    290                 295                 300                 





Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu His Thr 

305                 310                 315                 320 





Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr Gly Asp 

                325                 330                 335     





Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr Trp Tyr 

            340                 345                 350         





Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala Glu Tyr 

        355                 360                 365             





Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln Lys Thr 

    370                 375                 380                 





Ile Ala Glu Asn 

385             





<210>  279

<211>  142

<212>  PRT

<213>  Homo sapiens



<400>  279



Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly Cys Pro 

1               5                   10                  15      





Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr 

            20                  25                  30          





Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr 

        35                  40                  45              





Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys 

    50                  55                  60                  





Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro Glu Ile 

65                  70                  75                  80  





Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys Asn Tyr 

                85                  90                  95      





Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn Asn Glu 

            100                 105                 110         





Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu Cys Glu 

        115                 120                 125             





Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 

    130                 135                 140         





<210>  280

<211>  245

<212>  PRT

<213>  Homo sapiens



<400>  280



Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln Ala 

1               5                   10                  15      





Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile Asn 

            20                  25                  30          





Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His Ser 

        35                  40                  45              





Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val 

    50                  55                  60                  





Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro Asn 

65                  70                  75                  80  





Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Ser 

                85                  90                  95      





Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr Ala 

            100                 105                 110         





Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala Asn 

        115                 120                 125             





Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala Asp 

    130                 135                 140                 





Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu Lys 

145                 150                 155                 160 





Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu His 

                165                 170                 175     





Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr Gly 

            180                 185                 190         





Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr Trp 

        195                 200                 205             





Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala Glu 

    210                 215                 220                 





Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln Lys 

225                 230                 235                 240 





Thr Ile Ala Glu Asn 

                245 





<210>  281

<211>  347

<212>  PRT

<213>  Homo sapiens



<400>  281



Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 

1               5                   10                  15      





Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 

            20                  25                  30          





Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 

        35                  40                  45              





Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 

    50                  55                  60                  





Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 

65                  70                  75                  80  





Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro 

                85                  90                  95      





Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly 

            100                 105                 110         





Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr 

        115                 120                 125             





Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn 

    130                 135                 140                 





Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro 

145                 150                 155                 160 





Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys 

                165                 170                 175     





Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys 

            180                 185                 190         





Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu 

        195                 200                 205             





Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly 

    210                 215                 220                 





Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val 

225                 230                 235                 240 





Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly 

                245                 250                 255     





Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln 

            260                 265                 270         





Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln 

        275                 280                 285             





Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp 

    290                 295                 300                 





Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys 

305                 310                 315                 320 





Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile 

                325                 330                 335     





Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 

            340                 345         





<210>  282

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  282



Met Lys Leu Ala Val Thr Leu Thr Leu Val Thr Leu Ala Leu Cys Cys 

1               5                   10                  15      





Ser Ser Ala Ser Ala Glu Ile Cys Pro Ser Phe Gln Arg Val Ile Glu 

            20                  25                  30          





Thr Leu Leu Met Asp Thr Pro Ser Ser Tyr Glu Ala Ala Met Glu Leu 

        35                  40                  45              





Phe Ser Pro Asp Gln Asp Met Arg Glu Ala Gly Ala Gln Leu Lys Lys 

    50                  55                  60                  





Leu Val Asp Thr Leu Pro Gln Lys Pro Arg Glu Ser Ile Ile Lys Leu 

65                  70                  75                  80  





Met Glu Lys Ile Ala Gln Ser Ser Leu Cys Asn 

                85                  90      





<210>  283

<211>  70

<212>  PRT

<213>  Homo sapiens



<400>  283



Glu Ile Cys Pro Ser Phe Gln Arg Val Ile Glu Thr Leu Leu Met Asp 

1               5                   10                  15      





Thr Pro Ser Ser Tyr Glu Ala Ala Met Glu Leu Phe Ser Pro Asp Gln 

            20                  25                  30          





Asp Met Arg Glu Ala Gly Ala Gln Leu Lys Lys Leu Val Asp Thr Leu 

        35                  40                  45              





Pro Gln Lys Pro Arg Glu Ser Ile Ile Lys Leu Met Glu Lys Ile Ala 

    50                  55                  60                  





Gln Ser Ser Leu Cys Asn 

65                  70  





<210>  284

<211>  56

<212>  PRT

<213>  Homo sapiens



<400>  284



Met Asp Thr Pro Ser Ser Tyr Glu Ala Ala Met Glu Leu Phe Ser Pro 

1               5                   10                  15      





Asp Gln Asp Met Arg Glu Ala Gly Ala Gln Leu Lys Lys Leu Val Asp 

            20                  25                  30          





Thr Leu Pro Gln Lys Pro Arg Glu Ser Ile Ile Lys Leu Met Glu Lys 

        35                  40                  45              





Ile Ala Gln Ser Ser Leu Cys Asn 

    50                  55      





<210>  285

<211>  383

<212>  PRT

<213>  Homo sapiens



<400>  285



Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 

1               5                   10                  15      





Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 

            20                  25                  30          





Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 

        35                  40                  45              





Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 

    50                  55                  60                  





His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 

65                  70                  75                  80  





Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 

                85                  90                  95      





Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 

            100                 105                 110         





Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 

        115                 120                 125             





Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 

    130                 135                 140                 





Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 

145                 150                 155                 160 





Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 

                165                 170                 175     





Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 

            180                 185                 190         





Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 

        195                 200                 205             





His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 

    210                 215                 220                 





Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 

225                 230                 235                 240 





Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 

                245                 250                 255     





Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 

            260                 265                 270         





Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 

        275                 280                 285             





Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 

    290                 295                 300                 





Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 

305                 310                 315                 320 





Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 

                325                 330                 335     





Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 

            340                 345                 350         





Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 

        355                 360                 365             





Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 

    370                 375                 380             





<210>  286

<211>  362

<212>  PRT

<213>  Homo sapiens



<400>  286



Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser Gln Tyr Arg Glu Gly 

1               5                   10                  15      





Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg Phe Leu Cys Thr His 

            20                  25                  30          





Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp His Ile Asp Thr Trp 

        35                  40                  45              





Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu Asn Thr Leu Lys Asn 

    50                  55                  60                  





Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val Gly Gly Trp Asn Phe 

65                  70                  75                  80  





Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn Thr Gln Ser Arg Arg 

                85                  90                  95      





Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg Thr His Gly Phe Asp 

            100                 105                 110         





Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg Arg Asp Lys Gln His 

        115                 120                 125             





Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu Phe Ile Lys Glu Ala 

    130                 135                 140                 





Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala Ala Leu Ser Ala Gly 

145                 150                 155                 160 





Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala Lys Ile Ser Gln His 

                165                 170                 175     





Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe His Gly Ala Trp Arg 

            180                 185                 190         





Gly Thr Thr Gly His His Ser Pro Leu Phe Arg Gly Gln Glu Asp Ala 

        195                 200                 205             





Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala Val Gly Tyr Met Leu 

    210                 215                 220                 





Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met Gly Ile Pro Thr Phe 

225                 230                 235                 240 





Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr Gly Val Gly Ala Pro 

                245                 250                 255     





Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr Lys Glu Ala Gly Thr 

            260                 265                 270         





Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg Gly Ala Thr Val His 

        275                 280                 285             





Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr Lys Gly Asn Gln Trp 

    290                 295                 300                 





Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val Gln Tyr Leu 

305                 310                 315                 320 





Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp Ala Leu Asp Leu Asp 

                325                 330                 335     





Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu Arg Phe Pro Leu Thr 

            340                 345                 350         





Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 

        355                 360         





<210>  287

<211>  152

<212>  PRT

<213>  Homo sapiens





<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  Xaa can be any naturally occurring amino acid



<400>  287



Xaa Leu Leu Leu Ser Ala Ala Leu Ser Ala Gly Lys Val Thr Ile Asp 

1               5                   10                  15      





Ser Ser Tyr Asp Ile Ala Lys Ile Ser Gln His Leu Asp Phe Ile Ser 

            20                  25                  30          





Ile Met Thr Tyr Asp Phe His Gly Ala Trp Arg Gly Thr Thr Gly His 

        35                  40                  45              





His Ser Pro Leu Phe Arg Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe 

    50                  55                  60                  





Ser Asn Thr Ile Cys Asp Phe Leu Arg Gly Ala Thr Val His Arg Ile 

65                  70                  75                  80  





Leu Gly Gln Gln Val Pro Tyr Ala Thr Lys Gly Asn Gln Trp Val Gly 

                85                  90                  95      





Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val Gln Tyr Leu Lys Asp 

            100                 105                 110         





Arg Gln Leu Ala Gly Ala Met Val Trp Ala Leu Asp Leu Asp Asp Phe 

        115                 120                 125             





Gln Gly Ser Phe Cys Gly Gln Asp Leu Arg Phe Pro Leu Thr Asn Ala 

    130                 135                 140                 





Ile Lys Asp Ala Leu Ala Ala Thr 

145                 150         





<210>  288

<211>  117

<212>  PRT

<213>  Homo sapiens



<400>  288



Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly 

1               5                   10                  15      





Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln 

            20                  25                  30          





Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys 

        35                  40                  45              





Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro 

    50                  55                  60                  





Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu 

65                  70                  75                  80  





Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr 

                85                  90                  95      





Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala 

            100                 105                 110         





Cys Phe Val Pro Gln 

        115         





<210>  289

<211>  38

<212>  PRT

<213>  Homo sapiens



<400>  289



Ala Val Thr Gly Val Pro Val Lys Gly Gln Asp Thr Val Lys Gly Arg 

1               5                   10                  15      





Val Pro Phe Asn Gly Gln Asp Pro Val Lys Gly Gln Val Ser Val Lys 

            20                  25                  30          





Gly Gln Asp Lys Val Lys 

        35              





<210>  290

<211>  57

<212>  PRT

<213>  Homo sapiens



<400>  290



Ala Gln Glu Pro Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys 

1               5                   10                  15      





Pro Ile Ile Leu Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys 

            20                  25                  30          





Leu Lys Asp Thr Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser 

        35                  40                  45              





Cys Gly Met Ala Cys Phe Val Pro Gln 

    50                  55          





<210>  291

<211>  757

<212>  PRT

<213>  Homo sapiens



<400>  291



Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 

1               5                   10                  15      





Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 

            20                  25                  30          





Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 

        35                  40                  45              





Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 

    50                  55                  60                  





Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 

65                  70                  75                  80  





Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 

                85                  90                  95      





Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 

            100                 105                 110         





Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 

        115                 120                 125             





Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 

    130                 135                 140                 





Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 

145                 150                 155                 160 





Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 

                165                 170                 175     





Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 

            180                 185                 190         





Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 

        195                 200                 205             





Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 

    210                 215                 220                 





Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 

225                 230                 235                 240 





Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 

                245                 250                 255     





Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 

            260                 265                 270         





Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 

        275                 280                 285             





Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 

    290                 295                 300                 





Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 

305                 310                 315                 320 





Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 

                325                 330                 335     





Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 

            340                 345                 350         





Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 

        355                 360                 365             





Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 

    370                 375                 380                 





Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 

385                 390                 395                 400 





Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 

                405                 410                 415     





Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 

            420                 425                 430         





Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 

        435                 440                 445             





Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 

    450                 455                 460                 





Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 

465                 470                 475                 480 





Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 

                485                 490                 495     





Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 

            500                 505                 510         





Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 

        515                 520                 525             





Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 

    530                 535                 540                 





Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 

545                 550                 555                 560 





Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 

                565                 570                 575     





Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 

            580                 585                 590         





Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 

        595                 600                 605             





Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 

    610                 615                 620                 





Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 

625                 630                 635                 640 





Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 

                645                 650                 655     





Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 

            660                 665                 670         





Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 

        675                 680                 685             





Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 

    690                 695                 700                 





Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 

705                 710                 715                 720 





Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 

                725                 730                 735     





Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 

            740                 745                 750         





Gln Leu Arg Gln Ala 

        755         





<210>  292

<211>  737

<212>  PRT

<213>  Homo sapiens



<400>  292



Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro Gln Met Leu Arg 

1               5                   10                  15      





Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu 

            20                  25                  30          





Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu 

        35                  40                  45              





Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr Gly Leu Pro Ser 

    50                  55                  60                  





Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys Phe Pro Gly Val 

65                  70                  75                  80  





Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly Pro Cys Pro Ala 

                85                  90                  95      





Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val Asn Glu Cys Asn 

            100                 105                 110         





Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn Thr Ser Pro Gly 

        115                 120                 125             





Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly Pro Thr His Gln 

    130                 135                 140                 





Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln Val Cys Thr Asp 

145                 150                 155                 160 





Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro Asn Ser Val 

                165                 170                 175     





Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro Cys Gln Pro Gly 

            180                 185                 190         





Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg Ala Gln Arg Phe 

        195                 200                 205             





Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His Ala Asp Cys Val 

    210                 215                 220                 





Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val Gly Trp Ala 

225                 230                 235                 240 





Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu Asp Gly Phe Pro 

                245                 250                 255     





Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg Lys Asp Asn Cys 

            260                 265                 270         





Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg Asp Gly Ile 

        275                 280                 285             





Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val Pro Asn Glu 

    290                 295                 300                 





Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg Asn Thr Asp 

305                 310                 315                 320 





Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser Gln Lys Asn 

                325                 330                 335     





Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly Asp Ala Cys Asp 

            340                 345                 350         





Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala Asp Asn Cys Pro 

        355                 360                 365             





Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly Asp Gly Ile Gly 

    370                 375                 380                 





Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro Asp Gln Ala Asp 

385                 390                 395                 400 





Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp Gln Asp Gln 

                405                 410                 415     





Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys Pro Thr Val Pro 

            420                 425                 430         





Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln Gly Asp Ala Cys 

        435                 440                 445             





Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg Asp Asn Cys 

    450                 455                 460                 





Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp Arg Asp Gly Val 

465                 470                 475                 480 





Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys Val Val Asp Lys 

                485                 490                 495     





Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg 

            500                 505                 510         





Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp 

        515                 520                 525             





Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met 

    530                 535                 540                 





Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val 

545                 550                 555                 560 





Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp Asp Asp Tyr 

                565                 570                 575     





Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val 

            580                 585                 590         





Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro Phe Arg 

        595                 600                 605             





Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Ser Thr 

    610                 615                 620                 





Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly Asp Thr 

625                 630                 635                 640 





Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn Val Gly Trp 

                645                 650                 655     





Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val 

            660                 665                 670         





Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu Val Ala Asp 

        675                 680                 685             





Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val 

    690                 695                 700                 





Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg Tyr Arg 

705                 710                 715                 720 





Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His Gln Leu Arg Gln 

                725                 730                 735     





Ala 

    





<210>  293

<211>  704

<212>  PRT

<213>  Homo sapiens



<400>  293



Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 

1               5                   10                  15      





Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 

            20                  25                  30          





Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 

        35                  40                  45              





Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 

    50                  55                  60                  





Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 

65                  70                  75                  80  





Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 

                85                  90                  95      





Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 

            100                 105                 110         





Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 

        115                 120                 125             





Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro Asn Ser Val Cys 

    130                 135                 140                 





Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro Cys Gln Pro Gly Phe 

145                 150                 155                 160 





Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg Ala Gln Arg Phe Cys 

                165                 170                 175     





Pro Asp Gly Ser Pro Ser Glu Cys His Glu His Ala Asp Cys Val Leu 

            180                 185                 190         





Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val Gly Trp Ala Gly 

        195                 200                 205             





Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu Asp Gly Phe Pro Asp 

    210                 215                 220                 





Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg Lys Asp Asn Cys Val 

225                 230                 235                 240 





Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg Asp Gly Ile Gly 

                245                 250                 255     





Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val Pro Asn Glu Lys 

            260                 265                 270         





Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg Asn Thr Asp Glu 

        275                 280                 285             





Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser Gln Lys Asn Asp 

    290                 295                 300                 





Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly Asp Ala Cys Asp Asp 

305                 310                 315                 320 





Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala Asp Asn Cys Pro Arg 

                325                 330                 335     





Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly Asp Gly Ile Gly Asp 

            340                 345                 350         





Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro Asp Gln Ala Asp Val 

        355                 360                 365             





Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp Gln Asp Gln Asp 

    370                 375                 380                 





Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys Pro Thr Val Pro Asn 

385                 390                 395                 400 





Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln Gly Asp Ala Cys Asp 

                405                 410                 415     





Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg Asp Asn Cys Arg 

            420                 425                 430         





Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp Arg Asp Gly Val Gly 

        435                 440                 445             





Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys Val Val Asp Lys Ile 

    450                 455                 460                 





Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala 

465                 470                 475                 480 





Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro 

                485                 490                 495     





Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn 

            500                 505                 510         





Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp 

        515                 520                 525             





Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp Asp Asp Tyr Ala 

    530                 535                 540                 





Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met 

545                 550                 555                 560 





Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro Phe Arg Ala 

                565                 570                 575     





Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Ser Thr Gly 

            580                 585                 590         





Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly Asp Thr Glu 

        595                 600                 605             





Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn Val Gly Trp Lys 

    610                 615                 620                 





Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly 

625                 630                 635                 640 





Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu Val Ala Asp Ser 

                645                 650                 655     





Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe 

            660                 665                 670         





Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg Tyr Arg Cys 

        675                 680                 685             





Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His Gln Leu Arg Gln Ala 

    690                 695                 700                 





<210>  294

<211>  724

<212>  PRT

<213>  Homo sapiens



<400>  294



Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg 

1               5                   10                  15      





Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr 

            20                  25                  30          





Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr Gly 

        35                  40                  45              





Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys Phe 

    50                  55                  60                  





Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly Pro 

65                  70                  75                  80  





Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val Asn 

                85                  90                  95      





Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn Thr 

            100                 105                 110         





Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly Pro 

        115                 120                 125             





Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln Val 

    130                 135                 140                 





Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro 

145                 150                 155                 160 





Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro Cys 

                165                 170                 175     





Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg Ala 

            180                 185                 190         





Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His Ala 

        195                 200                 205             





Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val 

    210                 215                 220                 





Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu Asp 

225                 230                 235                 240 





Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg Lys 

                245                 250                 255     





Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg 

            260                 265                 270         





Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val 

        275                 280                 285             





Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg 

    290                 295                 300                 





Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser 

305                 310                 315                 320 





Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly Asp 

                325                 330                 335     





Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala Asp 

            340                 345                 350         





Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly Asp 

        355                 360                 365             





Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro Asp 

    370                 375                 380                 





Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp 

385                 390                 395                 400 





Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys Pro 

                405                 410                 415     





Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln Gly 

            420                 425                 430         





Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg 

        435                 440                 445             





Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp Arg 

    450                 455                 460                 





Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys Val 

465                 470                 475                 480 





Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr 

                485                 490                 495     





Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala 

            500                 505                 510         





Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile Val 

        515                 520                 525             





Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe 

    530                 535                 540                 





Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp 

545                 550                 555                 560 





Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe 

                565                 570                 575     





Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn 

            580                 585                 590         





Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys 

        595                 600                 605             





Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr 

    610                 615                 620                 





Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn 

625                 630                 635                 640 





Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His Arg 

                645                 650                 655     





Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu 

            660                 665                 670         





Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg 

        675                 680                 685             





Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu 

    690                 695                 700                 





Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His Gln 

705                 710                 715                 720 





Leu Arg Gln Ala 

                





<210>  295

<211>  1332

<212>  PRT

<213>  Homo sapiens



<400>  295



Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 

1               5                   10                  15      





Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 

            20                  25                  30          





Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 

        35                  40                  45              





Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 

    50                  55                  60                  





Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 

65                  70                  75                  80  





Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 

                85                  90                  95      





Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 

            100                 105                 110         





Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 

        115                 120                 125             





Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 

    130                 135                 140                 





Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 

145                 150                 155                 160 





Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 

                165                 170                 175     





Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 

            180                 185                 190         





Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 

        195                 200                 205             





Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 

    210                 215                 220                 





Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 

225                 230                 235                 240 





Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 

                245                 250                 255     





Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 

            260                 265                 270         





Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 

        275                 280                 285             





Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 

    290                 295                 300                 





Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 

305                 310                 315                 320 





Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 

                325                 330                 335     





Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 

            340                 345                 350         





Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 

        355                 360                 365             





Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 

    370                 375                 380                 





His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 

385                 390                 395                 400 





Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 

                405                 410                 415     





Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 

            420                 425                 430         





Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 

        435                 440                 445             





Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 

    450                 455                 460                 





Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 

465                 470                 475                 480 





Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 

                485                 490                 495     





Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 

            500                 505                 510         





Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 

        515                 520                 525             





Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 

    530                 535                 540                 





Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 

545                 550                 555                 560 





Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 

                565                 570                 575     





Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 

            580                 585                 590         





Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 

        595                 600                 605             





Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 

    610                 615                 620                 





Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 

625                 630                 635                 640 





Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 

                645                 650                 655     





Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 

            660                 665                 670         





Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 

        675                 680                 685             





Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 

    690                 695                 700                 





Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 

705                 710                 715                 720 





Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 

                725                 730                 735     





Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 

            740                 745                 750         





His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 

        755                 760                 765             





Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 

    770                 775                 780                 





Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 

785                 790                 795                 800 





Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 

                805                 810                 815     





Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 

            820                 825                 830         





Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 

        835                 840                 845             





Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 

    850                 855                 860                 





Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 

865                 870                 875                 880 





Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 

                885                 890                 895     





Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 

            900                 905                 910         





Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 

        915                 920                 925             





Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 

    930                 935                 940                 





Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 

945                 950                 955                 960 





Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 

                965                 970                 975     





Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 

            980                 985                 990         





Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 

        995                 1000                 1005             





Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 

    1010                 1015                 1020             





Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 

    1025                 1030                 1035             





Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 

    1040                 1045                 1050             





Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 

    1055                 1060                 1065             





Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 

    1070                 1075                 1080             





Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 

    1085                 1090                 1095             





Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 

    1100                 1105                 1110             





Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 

    1115                 1120                 1125             





Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 

    1130                 1135                 1140             





Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 

    1145                 1150                 1155             





Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 

    1160                 1165                 1170             





Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 

    1175                 1180                 1185             





Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 

    1190                 1195                 1200             





Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 

    1205                 1210                 1215             





Ala Ser  Asp Val Ser Val Glu  Ser Thr Ala Glu Ala  Thr Val Cys 

    1220                 1225                 1230             





Thr Val  Thr Leu Glu Lys Met  Ser Ala Gly Leu Gly  Phe Ser Leu 

    1235                 1240                 1245             





Glu Gly  Gly Lys Gly Ser Leu  His Gly Asp Lys Pro  Leu Thr Ile 

    1250                 1255                 1260             





Asn Arg  Ile Phe Lys Gly Ala  Ala Ser Glu Gln Ser  Glu Thr Val 

    1265                 1270                 1275             





Gln Pro  Gly Asp Glu Ile Leu  Gln Leu Gly Gly Thr  Ala Met Gln 

    1280                 1285                 1290             





Gly Leu  Thr Arg Phe Glu Ala  Trp Asn Ile Ile Lys  Ala Leu Pro 

    1295                 1300                 1305             





Asp Gly  Pro Val Thr Ile Val  Ile Arg Arg Lys Ser  Leu Gln Ser 

    1310                 1315                 1320             





Lys Glu  Thr Thr Ala Ala Gly  Asp Ser 

    1325                 1330         





<210>  296

<211>  121

<212>  PRT

<213>  Homo sapiens



<400>  296



Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 

1               5                   10                  15      





Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 

            20                  25                  30          





Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 

        35                  40                  45              





Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 

    50                  55                  60                  





Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 

65                  70                  75                  80  





Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 

                85                  90                  95      





Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 

            100                 105                 110         





Lys Glu Thr Thr Ala Ala Gly Asp Ser 

        115                 120     





<210>  297

<211>  1331

<212>  PRT

<213>  Homo sapiens



<400>  297



Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 

1               5                   10                  15      





Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 

            20                  25                  30          





Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 

        35                  40                  45              





Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 

    50                  55                  60                  





Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 

65                  70                  75                  80  





Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 

                85                  90                  95      





Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 

            100                 105                 110         





Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 

        115                 120                 125             





Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 

    130                 135                 140                 





Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 

145                 150                 155                 160 





Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 

                165                 170                 175     





Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 

            180                 185                 190         





Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 

        195                 200                 205             





Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 

    210                 215                 220                 





Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 

225                 230                 235                 240 





Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 

                245                 250                 255     





Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 

            260                 265                 270         





Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 

        275                 280                 285             





Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 

    290                 295                 300                 





Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 

305                 310                 315                 320 





Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 

                325                 330                 335     





Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 

            340                 345                 350         





Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 

        355                 360                 365             





Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 

    370                 375                 380                 





His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 

385                 390                 395                 400 





Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 

                405                 410                 415     





Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 

            420                 425                 430         





Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 

        435                 440                 445             





Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 

    450                 455                 460                 





Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 

465                 470                 475                 480 





Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 

                485                 490                 495     





Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 

            500                 505                 510         





Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 

        515                 520                 525             





Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 

    530                 535                 540                 





Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 

545                 550                 555                 560 





Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 

                565                 570                 575     





Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 

            580                 585                 590         





Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 

        595                 600                 605             





Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 

    610                 615                 620                 





Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 

625                 630                 635                 640 





Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 

                645                 650                 655     





Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 

            660                 665                 670         





Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 

        675                 680                 685             





Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 

    690                 695                 700                 





Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 

705                 710                 715                 720 





Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 

                725                 730                 735     





Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 

            740                 745                 750         





His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 

        755                 760                 765             





Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 

    770                 775                 780                 





Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 

785                 790                 795                 800 





Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 

                805                 810                 815     





Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 

            820                 825                 830         





Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 

        835                 840                 845             





Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 

    850                 855                 860                 





Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 

865                 870                 875                 880 





Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 

                885                 890                 895     





Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 

            900                 905                 910         





Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 

        915                 920                 925             





Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 

    930                 935                 940                 





Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 

945                 950                 955                 960 





Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 

                965                 970                 975     





Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 

            980                 985                 990         





Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 

        995                 1000                 1005             





Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 

    1010                 1015                 1020             





Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 

    1025                 1030                 1035             





Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 

    1040                 1045                 1050             





Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 

    1055                 1060                 1065             





Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 

    1070                 1075                 1080             





Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 

    1085                 1090                 1095             





Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 

    1100                 1105                 1110             





Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 

    1115                 1120                 1125             





Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 

    1130                 1135                 1140             





Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 

    1145                 1150                 1155             





Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 

    1160                 1165                 1170             





Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 

    1175                 1180                 1185             





Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 

    1190                 1195                 1200             





Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 

    1205                 1210                 1215             





Ala Ser  Asp Val Ser Val Glu  Ser Thr Glu Ala Thr  Val Cys Thr 

    1220                 1225                 1230             





Val Thr  Leu Glu Lys Met Ser  Ala Gly Leu Gly Phe  Ser Leu Glu 

    1235                 1240                 1245             





Gly Gly  Lys Gly Ser Leu His  Gly Asp Lys Pro Leu  Thr Ile Asn 

    1250                 1255                 1260             





Arg Ile  Phe Lys Gly Ala Ala  Ser Glu Gln Ser Glu  Thr Val Gln 

    1265                 1270                 1275             





Pro Gly  Asp Glu Ile Leu Gln  Leu Gly Gly Thr Ala  Met Gln Gly 

    1280                 1285                 1290             





Leu Thr  Arg Phe Glu Ala Trp  Asn Ile Ile Lys Ala  Leu Pro Asp 

    1295                 1300                 1305             





Gly Pro  Val Thr Ile Val Ile  Arg Arg Lys Ser Leu  Gln Ser Lys 

    1310                 1315                 1320             





Glu Thr  Thr Ala Ala Gly Asp  Ser 

    1325                 1330     





<210>  298

<211>  631

<212>  PRT

<213>  Homo sapiens



<400>  298



Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile 

1               5                   10                  15      





Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His 

            20                  25                  30          





Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly 

        35                  40                  45              





Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn 

    50                  55                  60                  





Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys 

65                  70                  75                  80  





Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys 

                85                  90                  95      





Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala 

            100                 105                 110         





Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His 

        115                 120                 125             





Ile Arg Ala Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser 

    130                 135                 140                 





Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg 

145                 150                 155                 160 





Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys 

                165                 170                 175     





His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro 

            180                 185                 190         





Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro 

        195                 200                 205             





Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro 

    210                 215                 220                 





Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu 

225                 230                 235                 240 





Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu 

                245                 250                 255     





Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln 

            260                 265                 270         





Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser 

        275                 280                 285             





Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu 

    290                 295                 300                 





Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly 

305                 310                 315                 320 





Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser 

                325                 330                 335     





Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu 

            340                 345                 350         





Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp 

        355                 360                 365             





Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu 

    370                 375                 380                 





Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp 

385                 390                 395                 400 





Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His 

                405                 410                 415     





Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp 

            420                 425                 430         





Leu Glu Asn Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu 

        435                 440                 445             





Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile 

    450                 455                 460                 





Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile 

465                 470                 475                 480 





Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys 

                485                 490                 495     





Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala 

            500                 505                 510         





Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Ala Glu 

        515                 520                 525             





Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly Leu Gly 

    530                 535                 540                 





Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys Pro Leu 

545                 550                 555                 560 





Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser Glu Thr 

                565                 570                 575     





Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala Met Gln 

            580                 585                 590         





Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu Pro Asp 

        595                 600                 605             





Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser Lys Glu 

    610                 615                 620                 





Thr Thr Ala Ala Gly Asp Ser 

625                 630     





<210>  299

<211>  560

<212>  PRT

<213>  Homo sapiens



<400>  299



Met Asp Tyr Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile 

1               5                   10                  15      





Ser Asp Cys Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His 

            20                  25                  30          





Gly His Met Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly 

        35                  40                  45              





Thr Gln Gly His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn 

    50                  55                  60                  





Gly Thr Pro Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys 

65                  70                  75                  80  





Gly Pro Pro Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys 

                85                  90                  95      





Gly Leu Arg Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala 

            100                 105                 110         





Leu Ser Thr Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His 

        115                 120                 125             





Ile Arg Ala Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser 

    130                 135                 140                 





Phe Glu Thr Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg 

145                 150                 155                 160 





Leu Ser Leu Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys 

                165                 170                 175     





His Glu Glu Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro 

            180                 185                 190         





Thr Leu Val Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro 

        195                 200                 205             





Ala Ala Ser Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro 

    210                 215                 220                 





Gly Arg Gln Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu 

225                 230                 235                 240 





Leu Arg Leu Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu 

                245                 250                 255     





Lys Met Pro Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln 

            260                 265                 270         





Ser Cys Glu Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser 

        275                 280                 285             





Ile Ser Ser Gln Val Ser Ser Ala Val Met Lys Ser Leu Leu Cys Leu 

    290                 295                 300                 





Pro Ser Ser Ile Ser Cys Ala Gln Thr Pro Cys Ile Pro Lys Glu Gly 

305                 310                 315                 320 





Ala Ser Pro Thr Ser Ser Ser Asn Glu Asp Ser Ala Ala Asn Gly Ser 

                325                 330                 335     





Ala Glu Thr Ser Ala Leu Asp Thr Gly Phe Ser Leu Asn Leu Ser Glu 

            340                 345                 350         





Leu Arg Glu Tyr Thr Glu Gly Leu Thr Glu Ala Lys Glu Asp Asp Asp 

        355                 360                 365             





Gly Asp His Ser Ser Leu Gln Ser Gly Gln Ser Val Ile Ser Leu Leu 

    370                 375                 380                 





Ser Ser Glu Glu Leu Lys Lys Leu Ile Glu Glu Val Lys Val Leu Asp 

385                 390                 395                 400 





Glu Ala Thr Leu Lys Gln Leu Asp Gly Ile His Val Thr Ile Leu His 

                405                 410                 415     





Lys Glu Glu Gly Ala Gly Leu Gly Phe Ser Leu Ala Gly Gly Ala Asp 

            420                 425                 430         





Leu Glu Asn Lys Val Ile Thr Val His Arg Val Phe Pro Asn Gly Leu 

        435                 440                 445             





Ala Ser Gln Glu Gly Thr Ile Gln Lys Gly Asn Glu Val Leu Ser Ile 

    450                 455                 460                 





Asn Gly Lys Ser Leu Lys Gly Thr Thr His His Asp Ala Leu Ala Ile 

465                 470                 475                 480 





Leu Arg Gln Ala Arg Glu Pro Arg Gln Ala Val Ile Val Thr Arg Lys 

                485                 490                 495     





Leu Thr Pro Glu Ala Met Pro Asp Leu Asn Ser Ser Thr Asp Ser Ala 

            500                 505                 510         





Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr Glu Ala 

        515                 520                 525             





Thr Val Cys Thr Val Thr Leu Glu Asp Val Gly Arg Ala Gly Leu Gln 

    530                 535                 540                 





Pro Gly Arg Arg Glu Gly Leu Pro Thr Arg Arg Gln Ala Ser His His 

545                 550                 555                 560 





<210>  300

<211>  911

<212>  PRT

<213>  Homo sapiens



<400>  300



Met Asp Gly Ala Met Gly Pro Arg Gly Leu Leu Leu Cys Met Tyr Leu 

1               5                   10                  15      





Val Ser Leu Leu Ile Leu Gln Ala Met Pro Ala Leu Gly Ser Ala Thr 

            20                  25                  30          





Gly Arg Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val 

        35                  40                  45              





Asp Gly Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser 

    50                  55                  60                  





Arg Phe Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn 

65                  70                  75                  80  





Glu Ala Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe 

                85                  90                  95      





Ile Ser Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp 

            100                 105                 110         





Ile Lys Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile 

        115                 120                 125             





Ser Gly Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu 

    130                 135                 140                 





Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe 

145                 150                 155                 160 





Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu 

                165                 170                 175     





Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile 

            180                 185                 190         





Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln 

        195                 200                 205             





Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser 

    210                 215                 220                 





Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln 

225                 230                 235                 240 





Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe 

                245                 250                 255     





Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val 

            260                 265                 270         





Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn 

        275                 280                 285             





Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 

    290                 295                 300                 





Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 

305                 310                 315                 320 





Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 

                325                 330                 335     





Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 

            340                 345                 350         





Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 

        355                 360                 365             





Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 

    370                 375                 380                 





Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 

385                 390                 395                 400 





Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 

                405                 410                 415     





Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 

            420                 425                 430         





Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 

        435                 440                 445             





Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 

    450                 455                 460                 





Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 

465                 470                 475                 480 





Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 

                485                 490                 495     





Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 

            500                 505                 510         





Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 

        515                 520                 525             





Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 

    530                 535                 540                 





Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 

545                 550                 555                 560 





His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 

                565                 570                 575     





Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 

            580                 585                 590         





Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 

        595                 600                 605             





Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 

    610                 615                 620                 





Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 

625                 630                 635                 640 





Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 

                645                 650                 655     





Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 

            660                 665                 670         





Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 

        675                 680                 685             





Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 

    690                 695                 700                 





Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 

705                 710                 715                 720 





Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 

                725                 730                 735     





Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 

            740                 745                 750         





Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 

        755                 760                 765             





Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 

    770                 775                 780                 





Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 

785                 790                 795                 800 





Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 

                805                 810                 815     





Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 

            820                 825                 830         





Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 

        835                 840                 845             





Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 

    850                 855                 860                 





Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 

865                 870                 875                 880 





His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 

                885                 890                 895     





Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 

            900                 905                 910     





<210>  301

<211>  638

<212>  PRT

<213>  Homo sapiens



<400>  301



Ser Lys Ser Ser Glu Lys Arg Gln Ala Val Asp Thr Ala Val Asp Gly 

1               5                   10                  15      





Val Phe Ile Arg Ser Leu Lys Val Asn Cys Lys Val Thr Ser Arg Phe 

            20                  25                  30          





Ala His Tyr Val Val Thr Ser Gln Val Val Asn Thr Ala Asn Glu Ala 

        35                  40                  45              





Arg Glu Val Ala Phe Asp Leu Glu Ile Pro Lys Thr Ala Phe Ile Ser 

    50                  55                  60                  





Asp Phe Ala Val Thr Ala Asp Gly Asn Ala Phe Ile Gly Asp Ile Lys 

65                  70                  75                  80  





Asp Lys Val Thr Ala Trp Lys Gln Tyr Arg Lys Ala Ala Ile Ser Gly 

                85                  90                  95      





Glu Asn Ala Gly Leu Val Arg Ala Ser Gly Arg Thr Met Glu Gln Phe 

            100                 105                 110         





Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val Thr Phe Gln Leu 

        115                 120                 125             





Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln Tyr Glu Ile Val 

    130                 135                 140                 





Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe Glu Ile Asp Val 

145                 150                 155                 160 





Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp Ala Gln Ala Ser 

                165                 170                 175     





Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys Lys Ser Phe Ser 

            180                 185                 190         





Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val Ser Gln Gln Gln 

        195                 200                 205             





Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly His Phe Lys Val 

    210                 215                 220                 





Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu Leu Val Ala Asn 

225                 230                 235                 240 





Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu Thr Asn Met Asn 

                245                 250                 255     





Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg Gly Gln 

            260                 265                 270         





Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly Asp Met 

        275                 280                 285             





Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg Val Gln 

    290                 295                 300                 





Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu Gln Ala 

305                 310                 315                 320 





Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr Asn Leu 

                325                 330                 335     





Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val Gln Glu 

            340                 345                 350         





Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met Leu Thr 

        355                 360                 365             





Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile Leu Lys 

    370                 375                 380                 





Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn Leu Gly 

385                 390                 395                 400 





Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser Met Glu 

                405                 410                 415     





Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala Thr Gln 

            420                 425                 430         





Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu Val Asp 

        435                 440                 445             





Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr Gln Asn 

    450                 455                 460                 





His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala Gly Arg 

465                 470                 475                 480 





Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln Ala His 

                485                 490                 495     





Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu Glu Glu 

            500                 505                 510         





Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn His Val 

        515                 520                 525             





Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala Lys Arg 

    530                 535                 540                 





Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln Ala Leu 

545                 550                 555                 560 





Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser Met Ser 

                565                 570                 575     





Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile Asp Lys 

            580                 585                 590         





Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg Arg Thr 

        595                 600                 605             





Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser Ser Asn 

    610                 615                 620                 





Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 

625                 630                 635             





<210>  302

<211>  239

<212>  PRT

<213>  Homo sapiens



<400>  302



Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 

1               5                   10                  15      





Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 

            20                  25                  30          





Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 

        35                  40                  45              





Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 

    50                  55                  60                  





Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 

65                  70                  75                  80  





Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 

                85                  90                  95      





Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 

            100                 105                 110         





Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 

        115                 120                 125             





Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 

    130                 135                 140                 





Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 

145                 150                 155                 160 





Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 

                165                 170                 175     





Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 

            180                 185                 190         





Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 

        195                 200                 205             





His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 

    210                 215                 220                 





Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 

225                 230                 235                 





<210>  303

<211>  769

<212>  PRT

<213>  Homo sapiens



<400>  303



Met Glu Gln Phe Thr Ile His Leu Thr Val Asn Pro Gln Ser Lys Val 

1               5                   10                  15      





Thr Phe Gln Leu Thr Tyr Glu Glu Val Leu Lys Arg Asn His Met Gln 

            20                  25                  30          





Tyr Glu Ile Val Ile Lys Val Lys Pro Lys Gln Leu Val His His Phe 

        35                  40                  45              





Glu Ile Asp Val Asp Ile Phe Glu Pro Gln Gly Ile Ser Lys Leu Asp 

    50                  55                  60                  





Ala Gln Ala Ser Phe Leu Pro Lys Glu Leu Ala Ala Gln Thr Ile Lys 

65                  70                  75                  80  





Lys Ser Phe Ser Gly Lys Lys Gly His Val Leu Phe Arg Pro Thr Val 

                85                  90                  95      





Ser Gln Gln Gln Ser Cys Pro Thr Cys Ser Thr Ser Leu Leu Asn Gly 

            100                 105                 110         





His Phe Lys Val Thr Tyr Asp Val Ser Arg Asp Lys Ile Cys Asp Leu 

        115                 120                 125             





Leu Val Ala Asn Asn His Phe Ala His Phe Phe Ala Pro Gln Asn Leu 

    130                 135                 140                 





Thr Asn Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser 

145                 150                 155                 160 





Met Arg Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile 

                165                 170                 175     





Leu Gly Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly 

            180                 185                 190         





Thr Arg Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala 

        195                 200                 205             





Asn Leu Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu 

    210                 215                 220                 





Ala Thr Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn 

225                 230                 235                 240 





Gln Val Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu 

                245                 250                 255     





Ile Met Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser 

            260                 265                 270         





Gln Ile Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu 

        275                 280                 285             





Tyr Asn Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val 

    290                 295                 300                 





Met Ser Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His 

305                 310                 315                 320 





Asp Ala Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro 

                325                 330                 335     





Leu Leu Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala 

            340                 345                 350         





Leu Thr Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val 

        355                 360                 365             





Val Ala Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp 

    370                 375                 380                 





Val Gln Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val 

385                 390                 395                 400 





Asp Glu Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu 

                405                 410                 415     





Glu Asn His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu 

            420                 425                 430         





Leu Ala Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser 

        435                 440                 445             





Ser Gln Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu 

    450                 455                 460                 





Thr Ser Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro 

465                 470                 475                 480 





Thr Ile Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly 

                485                 490                 495     





Pro Arg Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His 

            500                 505                 510         





Ser Ser Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp 

        515                 520                 525             





Thr Asp Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu 

    530                 535                 540                 





Cys Phe Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln 

545                 550                 555                 560 





Asp Pro Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys 

                565                 570                 575     





Ala Arg Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly 

            580                 585                 590         





Ile Ala Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn 

        595                 600                 605             





Ile Thr Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp 

    610                 615                 620                 





Gln Ala Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys 

625                 630                 635                 640 





Arg Asn Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val 

                645                 650                 655     





Leu His Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly 

            660                 665                 670         





Phe Tyr Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu 

        675                 680                 685             





Leu Gly Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His 

    690                 695                 700                 





Pro Gly Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn 

705                 710                 715                 720 





Arg Arg Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp 

                725                 730                 735     





Pro Trp His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly 

            740                 745                 750         





Ala Gly Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile 

        755                 760                 765             





Phe 

    





<210>  304

<211>  623

<212>  PRT

<213>  Homo sapiens



<400>  304



Met Asn Lys Asn Val Val Phe Val Ile Asp Ile Ser Gly Ser Met Arg 

1               5                   10                  15      





Gly Gln Lys Val Lys Gln Thr Lys Glu Ala Leu Leu Lys Ile Leu Gly 

            20                  25                  30          





Asp Met Gln Pro Gly Asp Tyr Phe Asp Leu Val Leu Phe Gly Thr Arg 

        35                  40                  45              





Val Gln Ser Trp Lys Gly Ser Leu Val Gln Ala Ser Glu Ala Asn Leu 

    50                  55                  60                  





Gln Ala Ala Gln Asp Phe Val Arg Gly Phe Ser Leu Asp Glu Ala Thr 

65                  70                  75                  80  





Asn Leu Asn Gly Gly Leu Leu Arg Gly Ile Glu Ile Leu Asn Gln Val 

                85                  90                  95      





Gln Glu Ser Leu Pro Glu Leu Ser Asn His Ala Ser Ile Leu Ile Met 

            100                 105                 110         





Leu Thr Asp Gly Asp Pro Thr Glu Gly Val Thr Asp Arg Ser Gln Ile 

        115                 120                 125             





Leu Lys Asn Val Arg Asn Ala Ile Arg Gly Arg Phe Pro Leu Tyr Asn 

    130                 135                 140                 





Leu Gly Phe Gly His Asn Val Asp Phe Asn Phe Leu Glu Val Met Ser 

145                 150                 155                 160 





Met Glu Asn Asn Gly Arg Ala Gln Arg Ile Tyr Glu Asp His Asp Ala 

                165                 170                 175     





Thr Gln Gln Leu Gln Gly Phe Tyr Ser Gln Val Ala Lys Pro Leu Leu 

            180                 185                 190         





Val Asp Val Asp Leu Gln Tyr Pro Gln Asp Ala Val Leu Ala Leu Thr 

        195                 200                 205             





Gln Asn His His Lys Gln Tyr Tyr Glu Gly Ser Glu Ile Val Val Ala 

    210                 215                 220                 





Gly Arg Ile Ala Asp Asn Lys Gln Ser Ser Phe Lys Ala Asp Val Gln 

225                 230                 235                 240 





Ala His Gly Glu Gly Gln Glu Phe Ser Ile Thr Cys Leu Val Asp Glu 

                245                 250                 255     





Glu Glu Met Lys Lys Leu Leu Arg Glu Arg Gly His Met Leu Glu Asn 

            260                 265                 270         





His Val Glu Arg Leu Trp Ala Tyr Leu Thr Ile Gln Glu Leu Leu Ala 

        275                 280                 285             





Lys Arg Met Lys Val Asp Arg Glu Glu Arg Ala Asn Leu Ser Ser Gln 

    290                 295                 300                 





Ala Leu Gln Met Ser Leu Asp Tyr Gly Phe Val Thr Pro Leu Thr Ser 

305                 310                 315                 320 





Met Ser Ile Arg Gly Met Ala Asp Gln Asp Gly Leu Lys Pro Thr Ile 

                325                 330                 335     





Asp Lys Pro Ser Glu Asp Ser Pro Pro Leu Glu Met Leu Gly Pro Arg 

            340                 345                 350         





Arg Thr Phe Val Leu Ser Ala Leu Gln Pro Ser Pro Thr His Ser Ser 

        355                 360                 365             





Ser Asn Thr Gln Arg Leu Pro Asp Arg Val Thr Gly Val Asp Thr Asp 

    370                 375                 380                 





Pro His Phe Ile Ile His Val Pro Gln Lys Glu Asp Thr Leu Cys Phe 

385                 390                 395                 400 





Asn Ile Asn Glu Glu Pro Gly Val Ile Leu Ser Leu Val Gln Asp Pro 

                405                 410                 415     





Asn Thr Gly Phe Ser Val Asn Gly Gln Leu Ile Gly Asn Lys Ala Arg 

            420                 425                 430         





Ser Pro Gly Gln His Asp Gly Thr Tyr Phe Gly Arg Leu Gly Ile Ala 

        435                 440                 445             





Asn Pro Ala Thr Asp Phe Gln Leu Glu Val Thr Pro Gln Asn Ile Thr 

    450                 455                 460                 





Leu Asn Pro Gly Phe Gly Gly Pro Val Phe Ser Trp Arg Asp Gln Ala 

465                 470                 475                 480 





Val Leu Arg Gln Asp Gly Val Val Val Thr Ile Asn Lys Lys Arg Asn 

                485                 490                 495     





Leu Val Val Ser Val Asp Asp Gly Gly Thr Phe Glu Val Val Leu His 

            500                 505                 510         





Arg Val Trp Lys Gly Ser Ser Val His Gln Asp Phe Leu Gly Phe Tyr 

        515                 520                 525             





Val Leu Asp Ser His Arg Met Ser Ala Arg Thr His Gly Leu Leu Gly 

    530                 535                 540                 





Gln Phe Phe His Pro Ile Gly Phe Glu Val Ser Asp Ile His Pro Gly 

545                 550                 555                 560 





Ser Asp Pro Thr Lys Pro Asp Ala Thr Met Val Val Arg Asn Arg Arg 

                565                 570                 575     





Leu Thr Val Thr Arg Gly Leu Gln Lys Asp Tyr Ser Lys Asp Pro Trp 

            580                 585                 590         





His Gly Ala Glu Val Ser Cys Trp Phe Ile His Asn Asn Gly Ala Gly 

        595                 600                 605             





Leu Ile Asp Gly Ala Tyr Thr Asp Tyr Ile Val Pro Asp Ile Phe 

    610                 615                 620             





