                         SEQUENCE LISTING

<110>  INSERM
 
<120>  USE OF CDON INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL 
       DYSFUNCTION

<130>  BIO18554 RENAULT / MC

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  1287
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Pro Asp Leu Gly Pro Leu Cys Thr Leu Leu Tyr Val Thr Leu 
1               5                   10                  15      


Thr Ile Leu Cys Ser Ser Val Ser Ser Asp Leu Ala Pro Tyr Phe Thr 
            20                  25                  30          


Ser Glu Pro Leu Ser Ala Val Gln Lys Leu Gly Gly Pro Val Val Leu 
        35                  40                  45              


His Cys Ser Ala Gln Pro Val Thr Thr Arg Ile Ser Trp Leu His Asn 
    50                  55                  60                  


Gly Lys Thr Leu Asp Gly Asn Leu Glu His Val Lys Ile His Gln Gly 
65                  70                  75                  80  


Thr Leu Thr Ile Leu Ser Leu Asn Ser Ser Leu Leu Gly Tyr Tyr Gln 
                85                  90                  95      


Cys Leu Ala Asn Asn Ser Ile Gly Ala Ile Val Ser Gly Pro Ala Thr 
            100                 105                 110         


Val Ser Val Ala Val Leu Gly Asp Phe Gly Ser Ser Thr Lys His Val 
        115                 120                 125             


Ile Thr Ala Glu Glu Lys Ser Ala Gly Phe Ile Gly Cys Arg Val Pro 
    130                 135                 140                 


Glu Ser Asn Pro Lys Ala Glu Val Arg Tyr Lys Ile Arg Gly Lys Trp 
145                 150                 155                 160 


Leu Glu His Ser Thr Glu Asn Tyr Leu Ile Leu Pro Ser Gly Asn Leu 
                165                 170                 175     


Gln Ile Leu Asn Val Ser Leu Glu Asp Lys Gly Ser Tyr Lys Cys Ala 
            180                 185                 190         


Ala Tyr Asn Pro Val Thr His Gln Leu Lys Val Glu Pro Ile Gly Arg 
        195                 200                 205             


Lys Leu Leu Val Ser Arg Pro Ser Ser Asp Asp Val His Ile Leu His 
    210                 215                 220                 


Pro Thr His Ser Gln Ala Leu Ala Val Leu Ser Arg Ser Pro Val Thr 
225                 230                 235                 240 


Leu Glu Cys Val Val Ser Gly Val Pro Ala Pro Gln Val Tyr Trp Leu 
                245                 250                 255     


Lys Asp Gly Gln Asp Ile Ala Pro Gly Ser Asn Trp Arg Arg Leu Tyr 
            260                 265                 270         


Ser His Leu Ala Thr Asp Ser Val Asp Pro Ala Asp Ser Gly Asn Tyr 
        275                 280                 285             


Ser Cys Met Ala Gly Asn Lys Ser Gly Asp Val Lys Tyr Val Thr Tyr 
    290                 295                 300                 


Met Val Asn Val Leu Glu His Ala Ser Ile Ser Lys Gly Leu Gln Asp 
305                 310                 315                 320 


Gln Ile Val Ser Leu Gly Ala Thr Val His Phe Thr Cys Asp Val His 
                325                 330                 335     


Gly Asn Pro Ala Pro Asn Cys Thr Trp Phe His Asn Ala Gln Pro Ile 
            340                 345                 350         


His Pro Ser Ala Arg His Leu Thr Ala Gly Asn Gly Leu Lys Ile Ser 
        355                 360                 365             


Gly Val Thr Val Glu Asp Val Gly Met Tyr Gln Cys Val Ala Asp Asn 
    370                 375                 380                 


Gly Ile Gly Phe Met His Ser Thr Gly Arg Leu Glu Ile Glu Asn Asp 
385                 390                 395                 400 


Gly Gly Phe Lys Pro Val Ile Ile Thr Ala Pro Val Ser Ala Lys Val 
                405                 410                 415     


Ala Asp Gly Asp Phe Val Thr Leu Ser Cys Asn Ala Ser Gly Leu Pro 
            420                 425                 430         


Val Pro Val Ile Arg Trp Tyr Asp Ser His Gly Leu Ile Thr Ser His 
        435                 440                 445             


Pro Ser Gln Val Leu Arg Ser Lys Ser Arg Lys Ser Gln Leu Ser Arg 
    450                 455                 460                 


Pro Glu Gly Leu Asn Leu Glu Pro Val Tyr Phe Val Leu Ser Gln Ala 
465                 470                 475                 480 


Gly Ala Ser Ser Leu His Ile Gln Ala Val Thr Gln Glu His Ala Gly 
                485                 490                 495     


Lys Tyr Ile Cys Glu Ala Ala Asn Glu His Gly Thr Thr Gln Ala Glu 
            500                 505                 510         


Ala Ser Leu Met Val Val Pro Phe Glu Thr Asn Thr Lys Ala Glu Thr 
        515                 520                 525             


Val Thr Leu Pro Asp Ala Ala Gln Asn Asp Asp Arg Ser Lys Arg Asp 
    530                 535                 540                 


Gly Ser Glu Thr Gly Leu Leu Ser Ser Phe Pro Val Lys Val His Pro 
545                 550                 555                 560 


Ser Ala Val Glu Ser Ala Pro Glu Lys Asn Ala Ser Gly Ile Ser Val 
                565                 570                 575     


Pro Asp Ala Pro Ile Ile Leu Ser Pro Pro Gln Thr His Thr Pro Asp 
            580                 585                 590         


Thr Tyr Asn Leu Val Trp Arg Ala Gly Lys Asp Gly Gly Leu Pro Ile 
        595                 600                 605             


Asn Ala Tyr Phe Val Lys Tyr Arg Lys Leu Asp Asp Gly Val Gly Met 
    610                 615                 620                 


Leu Gly Ser Trp His Thr Val Arg Val Pro Gly Ser Glu Asn Glu Leu 
625                 630                 635                 640 


His Leu Ala Glu Leu Glu Pro Ser Ser Leu Tyr Glu Val Leu Met Val 
                645                 650                 655     


Ala Arg Ser Ala Ala Gly Glu Gly Gln Pro Ala Met Leu Thr Phe Arg 
            660                 665                 670         


Thr Ser Lys Glu Lys Thr Ala Ser Ser Lys Asn Thr Gln Ala Ser Ser 
        675                 680                 685             


Pro Pro Val Gly Ile Pro Lys Tyr Pro Val Val Ser Glu Ala Ala Asn 
    690                 695                 700                 


Asn Asn Phe Gly Val Val Leu Thr Asp Ser Ser Arg His Ser Gly Val 
705                 710                 715                 720 


Pro Glu Ala Pro Asp Arg Pro Thr Ile Ser Thr Ala Ser Glu Thr Ser 
                725                 730                 735     


Val Tyr Val Thr Trp Ile Pro Arg Ala Asn Gly Gly Ser Pro Ile Thr 
            740                 745                 750         


Ala Phe Lys Val Glu Tyr Lys Arg Met Arg Thr Ser Asn Trp Leu Val 
        755                 760                 765             


Ala Ala Glu Asp Ile Pro Pro Ser Lys Leu Ser Val Glu Val Arg Ser 
    770                 775                 780                 


Leu Glu Pro Gly Ser Thr Tyr Lys Phe Arg Val Ile Ala Ile Asn His 
785                 790                 795                 800 


Tyr Gly Glu Ser Phe Arg Ser Ser Ala Ser Arg Pro Tyr Gln Val Val 
                805                 810                 815     


Gly Phe Pro Asn Arg Phe Ser Ser Arg Pro Ile Thr Gly Pro His Ile 
            820                 825                 830         


Ala Tyr Thr Glu Ala Val Ser Asp Thr Gln Ile Met Leu Lys Trp Thr 
        835                 840                 845             


Tyr Ile Pro Ser Ser Asn Asn Asn Thr Pro Ile Gln Gly Phe Tyr Ile 
    850                 855                 860                 


Tyr Tyr Arg Pro Thr Asp Ser Asp Asn Asp Ser Asp Tyr Lys Arg Asp 
865                 870                 875                 880 


Val Val Glu Gly Ser Lys Gln Trp His Met Ile Gly His Leu Gln Pro 
                885                 890                 895     


Glu Thr Ser Tyr Asp Ile Lys Met Gln Cys Phe Asn Glu Gly Gly Glu 
            900                 905                 910         


Ser Glu Phe Ser Asn Val Met Ile Cys Glu Thr Lys Val Lys Arg Val 
        915                 920                 925             


Pro Gly Ala Ser Glu Tyr Pro Val Lys Asp Leu Ser Thr Pro Pro Asn 
    930                 935                 940                 


Ser Leu Gly Ser Gly Gly Asn Val Gly Pro Ala Thr Ser Pro Ala Arg 
945                 950                 955                 960 


Ser Ser Asp Met Leu Tyr Leu Ile Val Gly Cys Val Leu Gly Val Met 
                965                 970                 975     


Val Leu Ile Leu Met Val Phe Ile Ala Met Cys Leu Trp Lys Asn Arg 
            980                 985                 990         


Gln Gln Asn Thr Ile Gln Lys Tyr  Asp Pro Pro Gly Tyr  Leu Tyr Gln 
        995                 1000                 1005             


Gly Ser  Asp Met Asn Gly Gln  Met Val Asp Tyr Thr  Thr Leu Ser 
    1010                 1015                 1020             


Gly Ala  Ser Gln Ile Asn Gly  Asn Val His Gly Gly  Phe Leu Thr 
    1025                 1030                 1035             


Asn Gly  Gly Leu Ser Ser Gly  Tyr Ser His Leu His  His Lys Val 
    1040                 1045                 1050             


Pro Asn  Ala Val Asn Gly Ile  Val Asn Gly Ser Leu  Asn Gly Gly 
    1055                 1060                 1065             


Leu Tyr  Ser Gly His Ser Asn  Ser Leu Thr Arg Thr  His Val Asp 
    1070                 1075                 1080             


Phe Glu  His Pro His His Leu  Val Asn Gly Gly Gly  Met Tyr Thr 
    1085                 1090                 1095             


Ala Val  Pro Gln Ile Asp Pro  Leu Glu Cys Val Asn  Cys Arg Asn 
    1100                 1105                 1110             


Cys Arg  Asn Asn Asn Arg Cys  Phe Thr Lys Thr Asn  Ser Thr Phe 
    1115                 1120                 1125             


Ser Ser  Ser Pro Pro Pro Val  Val Pro Val Val Ala  Pro Tyr Pro 
    1130                 1135                 1140             


Gln Asp  Gly Leu Glu Met Lys  Pro Leu Ser His Val  Lys Val Pro 
    1145                 1150                 1155             


Val Cys  Leu Thr Ser Ala Val  Pro Asp Cys Gly Gln  Leu Pro Glu 
    1160                 1165                 1170             


Glu Ser  Val Lys Asp Asn Val  Glu Pro Val Pro Thr  Gln Arg Thr 
    1175                 1180                 1185             


Cys Cys  Gln Asp Ile Val Asn  Asp Val Ser Ser Asp  Gly Ser Glu 
    1190                 1195                 1200             


Asp Pro  Ala Glu Phe Ser Arg  Gly Gln Glu Gly Met  Ile Asn Leu 
    1205                 1210                 1215             


Arg Ile  Pro Asp His Leu Gln  Leu Ala Lys Ser Cys  Val Trp Glu 
    1220                 1225                 1230             


Gly Asp  Ser Cys Ala His Ser  Glu Thr Glu Ile Asn  Ile Val Ser 
    1235                 1240                 1245             


Trp Asn  Ala Leu Ile Leu Pro  Pro Val Pro Glu Gly  Cys Ala Glu 
    1250                 1255                 1260             


Lys Thr  Met Trp Ser Pro Pro  Gly Ile Pro Leu Asp  Ser Pro Thr 
    1265                 1270                 1275             


Glu Val  Leu Gln Gln Pro Arg  Glu Thr 
    1280                 1285         


<210>  2
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Leu Thr Asn Leu Leu Pro Leu Cys Cys Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Pro Ala Gln Ser Cys Gly Pro Gly Arg Gly Pro Val Gly Arg 
            20                  25                  30          


Arg Arg Tyr Ala Arg Lys Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe 
        35                  40                  45              


Val Pro Gly Val Pro Glu Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu 
    50                  55                  60                  


Gly Arg Val Ala Arg Gly Ser Glu Arg Phe Arg Asp Leu Val Pro Asn 
65                  70                  75                  80  


Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp 
                85                  90                  95      


Arg Leu Met Thr Glu Arg Cys Lys Glu Arg Val Asn Ala Leu Ala Ile 
            100                 105                 110         


Ala Val Met Asn Met Trp Pro Gly Val Arg Leu Arg Val Thr Glu Gly 
        115                 120                 125             


Trp Asp Glu Asp Gly His His Ala Gln Asp Ser Leu His Tyr Glu Gly 
    130                 135                 140                 


Arg Ala Leu Asp Ile Thr Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr 
                165                 170                 175     


Glu Ser Arg Asn His Val His Val Ser Val Lys Ala Asp Asn Ser Leu 
            180                 185                 190         


Ala Val Arg Ala Gly Gly Cys Phe Pro Gly Asn Ala Thr Val Arg Leu 
        195                 200                 205             


Trp Ser Gly Glu Arg Lys Gly Leu Arg Glu Leu His Arg Gly Asp Trp 
    210                 215                 220                 


Val Leu Ala Ala Asp Ala Ser Gly Arg Val Val Pro Thr Pro Val Leu 
225                 230                 235                 240 


Leu Phe Leu Asp Arg Asp Leu Gln Arg Arg Ala Ser Phe Val Ala Val 
                245                 250                 255     


Glu Thr Glu Trp Pro Pro Arg Lys Leu Leu Leu Thr Pro Trp His Leu 
            260                 265                 270         


Val Phe Ala Ala Arg Gly Pro Ala Pro Ala Pro Gly Asp Phe Ala Pro 
        275                 280                 285             


Val Phe Ala Arg Arg Leu Arg Ala Gly Asp Ser Val Leu Ala Pro Gly 
    290                 295                 300                 


Gly Asp Ala Leu Arg Pro Ala Arg Val Ala Arg Val Ala Arg Glu Glu 
305                 310                 315                 320 


Ala Val Gly Val Phe Ala Pro Leu Thr Ala His Gly Thr Leu Leu Val 
                325                 330                 335     


Asn Asp Val Leu Ala Ser Cys Tyr Ala Val Leu Glu Ser His Gln Trp 
            340                 345                 350         


Ala His Arg Ala Phe Ala Pro Leu Arg Leu Leu His Ala Leu Gly Ala 
        355                 360                 365             


Leu Leu Pro Gly Gly Ala Val Gln Pro Thr Gly Met His Trp Tyr Ser 
    370                 375                 380                 


Arg Leu Leu Tyr Arg Leu Ala Glu Glu Leu Leu Gly 
385                 390                 395     


