                         SEQUENCE LISTING

<110>  Universitaet Zuerich
 
<120>  ARTC1 Ligands for Cancer Treatment

<130>  uz427wo

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Met Pro Ala Met Met Ser Leu Leu Leu Val Ser Val Gly Leu 
1               5                   10                  15      


Met Glu Ala Leu Gln Ala Gln Ser His Pro Ile Thr Arg Arg Asp Leu 
            20                  25                  30          


Phe Ser Gln Glu Ile Gln Leu Asp Met Ala Leu Ala Ser Phe Asp Asp 
        35                  40                  45              


Gln Tyr Ala Gly Cys Ala Ala Ala Met Thr Ala Ala Leu Pro Asp Leu 
    50                  55                  60                  


Asn His Thr Glu Phe Gln Ala Asn Gln Val Tyr Ala Asp Ser Trp Thr 
65                  70                  75                  80  


Leu Ala Ser Ser Gln Trp Gln Glu Arg Gln Ala Arg Trp Pro Glu Trp 
                85                  90                  95      


Ser Leu Ser Pro Thr Arg Pro Ser Pro Pro Pro Leu Gly Phe Arg Asp 
            100                 105                 110         


Glu His Gly Val Ala Leu Leu Ala Tyr Thr Ala Asn Ser Pro Leu His 
        115                 120                 125             


Lys Glu Phe Asn Ala Ala Val Arg Glu Ala Gly Arg Ser Arg Ala His 
    130                 135                 140                 


Tyr Leu His His Phe Ser Phe Lys Thr Leu His Phe Leu Leu Thr Glu 
145                 150                 155                 160 


Ala Leu Gln Leu Leu Gly Ser Gly Gln Arg Pro Pro Arg Cys His Gln 
                165                 170                 175     


Val Phe Arg Gly Val His Gly Leu Arg Phe Arg Pro Ala Gly Pro Arg 
            180                 185                 190         


Ala Thr Val Arg Leu Gly Gly Phe Ala Ser Ala Ser Leu Lys His Val 
        195                 200                 205             


Ala Ala Gln Gln Phe Gly Glu Asp Thr Phe Phe Gly Ile Trp Thr Cys 
    210                 215                 220                 


Leu Gly Ala Pro Ile Lys Gly Tyr Ser Phe Phe Pro Gly Glu Glu Glu 
225                 230                 235                 240 


Val Leu Ile Pro Pro Phe Glu Thr Phe Gln Val Ile Asn Ala Ser Arg 
                245                 250                 255     


Leu Ala Gln Gly Pro Ala Arg Ile Tyr Leu Arg Ala Leu Gly Lys His 
            260                 265                 270         


Ser Thr Tyr Asn Cys Glu Tyr Ile Lys Asp Lys Lys Cys Lys Ser Gly 
        275                 280                 285             


Pro Cys His Leu Asp Asn Ser Ala Met Gly Gln Ser Pro Leu Ser Ala 
    290                 295                 300                 


Val Trp Ser Leu Leu Leu Leu Leu Trp Phe Leu Val Val Arg Ala Phe 
305                 310                 315                 320 


Pro Asp Gly Pro Gly Leu Leu 
                325         


<210>  2
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ala Leu Gln Leu Leu Gly Ser Gly Gln Arg Pro Pro Arg Cys His 
1               5                   10                  15      


Gln Val Phe Arg Gly Val His Gly Leu Arg Phe Arg Pro Ala Gly Pro 
            20                  25                  30          


Arg Ala Thr Val Arg Leu Gly Gly Phe 
        35                  40      


<210>  3
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Val His Gly Leu Arg Phe Arg Pro Ala Gly Pro Arg Ala Thr Val 
1               5                   10                  15      


Arg Leu Gly Gly Phe Ala Ser Ala Ser Leu Lys His Val Ala Ala Gln 
            20                  25                  30          


Gln Phe Gly Glu Asp Thr Phe Phe Gly 
        35                  40      


<210>  4
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Ile Trp Thr Cys Leu Gly Ala Pro Ile Lys Gly Tyr Ser Phe Phe 
1               5                   10                  15      


Pro Gly Glu Glu Glu Val Leu Ile Pro Pro Phe Glu Thr Phe Gln Val 
            20                  25                  30          


Ile Asn Ala Ser Arg Leu Ala Gln Gly 
        35                  40      


<210>  5
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Asp Gly Val Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Thr Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Arg Gly Ala Ala Pro Phe Asp Phe Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Ser Cys Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  7
<211>  240
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Tyr Asp Gly Val Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Thr Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Ala Lys Arg Gly Ala Ala Pro Phe Asp Phe Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr 
    130                 135                 140                 


Met Thr Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ala Ser 
                165                 170                 175     


Pro Lys Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Tyr Pro Ser Cys Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Ala 
225                 230                 235                 240 


<210>  8
<211>  123
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Val Trp Val Arg Gln Ala Pro Lys Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Tyr Asp Gly Ser Arg Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Gly Tyr Thr Thr Asp Tyr Tyr Tyr Val Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Asp Val Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Gly Lys Val Thr Leu Thr Cys Arg Ala Ser Ser Gly Val Ser Tyr Met 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Asp Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Gly Thr Ser Lys Leu Ala Ser Gly Val Pro Asn Arg Phe Thr Ala Gly 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Ile Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Cys Cys Ser Thr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  10
<211>  249
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Val Trp Val Arg Gln Ala Pro Lys Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Tyr Asp Gly Ser Arg Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Gly Tyr Thr Thr Asp Tyr Tyr Tyr Val Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Leu Glu Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Asp Val Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly Gly Lys Val Thr 
145                 150                 155                 160 


Leu Thr Cys Arg Ala Ser Ser Gly Val Ser Tyr Met Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Asp Ser Pro Lys Leu Trp Ile Tyr Gly Thr Ser Lys 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Asn Arg Phe Thr Ala Gly Gly Ser Gly Thr 
        195                 200                 205             


Ser Tyr Ser Leu Ile Ile Ser Ser Met Glu Thr Glu Asp Val Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Cys Cys Ser Thr Pro Leu Thr Phe Gly Ser Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Ala Ala Ala 
                245                 


<210>  11
<211>  123
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Glu Val Leu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Pro Met Ala Trp Val Arg Leu Thr Pro Thr Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Ser Pro Leu Tyr Tyr Ser Asn Tyr Val Gly Asn Val Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  113
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Phe Glu Ile 
            100                 105                 110         


Lys 
    


<210>  13
<211>  259
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Ala Glu Val Leu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asp Phe Pro Met Ala Trp Val Arg Leu Thr Pro Thr Arg Gly Leu Glu 
        35                  40                  45              


Trp Val Ala Thr Ile Ser Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Gly 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Thr Ser Pro Leu Tyr Tyr Ser Asn Tyr Val Gly Asn Val Met 
            100                 105                 110         


Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser Leu Glu Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Asp Ile 
    130                 135                 140                 


Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Val Gly Glu Met 
145                 150                 155                 160 


Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser Gly Asn 
                165                 170                 175     


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg Gln Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln His Tyr 
225                 230                 235                 240 


Ile Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Phe Glu Ile Lys Ala 
                245                 250                 255     


Ala Ala Val 
            


<210>  14
<211>  116
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ile Asn 
            20                  25                  30          


Tyr Trp Asp Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Ser Glu Gly Ala Gly Gly Leu Asp Tyr Trp Gly Gln Gly Val Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  110
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val Ser Leu Glu Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Cys Lys Thr Ser Gln Asn Val Asp Tyr Tyr Gly 
            20                  25                  30          


Ile Thr Tyr Met His Trp Tyr Gln Gln Lys Pro Arg His His Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Glu Gly Ser Asn Leu Pro Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro 
65                  70                  75                  80  


Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Asp 
                85                  90                  95      


Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110 


<210>  16
<211>  248
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Ala Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
1               5                   10                  15      


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
            20                  25                  30          


Ile Asn Tyr Trp Asp Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu 
        35                  40                  45              


Trp Ile Gly His Ile Asn Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Ser Glu Gly Ala Gly Gly Leu Asp Tyr Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ala Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Leu Ala Val Ser Leu Glu Gln Arg Ala Thr Ile Ser Cys Lys Thr Ser 
145                 150                 155                 160 


Gln Asn Val Asp Tyr Tyr Gly Ile Thr Tyr Met His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Arg His His Pro Lys Leu Leu Ile Tyr Glu Gly Ser Asn Leu 
            180                 185                 190         


Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Lys Asp Tyr Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Ala Ala Ala 
                245             


<210>  17
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Ile Ser Gly Gly Ala Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg His Asn Ala Thr Gly Thr Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Asp Gly Ser Ser Arg Gly Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Thr Ala Ile Pro Val Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Thr Met Glu Thr Glu 
65                  70                  75                  80  


Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Ser Met 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  19
<211>  250
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Met Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Phe Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala Val Val Ser Ile Ser Gly Gly Ala Thr Tyr Tyr Arg Asp 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg His Asn Ala Thr Gly Thr 
65                  70                  75                  80  


Leu Tyr Leu His Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Asp Gly Ser Ser Arg Gly Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Leu Glu Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Thr Ala Ile Pro Val Ser Pro Gly Glu Lys Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln 
                165                 170                 175     


Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr Asp Thr Ser Lys 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Ser Tyr Ser Leu Thr Ile Asn Thr Met Glu Thr Glu Asp Gly Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Ser Met Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Leu Lys Ala Ala Ala 
                245                 250 


<210>  20
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Arg Ala Ser Ser Gly Val Ser Tyr Met Ala 
1               5                   10  


<210>  22
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Lys Ser Ser Gln Ser Leu Leu Ser Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  23

Lys Thr Ser Gln Asn Val Asp Tyr Tyr Gly Ile Thr Tyr Met His 
1               5                   10                  15  


<210>  24
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  25
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  25

Glu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Gly Thr Ser Lys Leu Ala Ser 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  27

Tyr Ala Ser Thr Arg Gln Ser 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Glu Gly Ser Asn Leu Pro Ser 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  29

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  30

Gln Gln Trp Asn Tyr Pro Ser Cys Thr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  31

Gln Gln Cys Cys Ser Thr Pro Leu Thr 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Leu Gln His Tyr Ile Ser Pro Phe Thr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Gln Gln Ser Lys Asp Tyr Pro Trp Thr 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Gln Gln Trp Ser Ser Ser Pro Ser Met Thr 
1               5                   10  


<210>  35
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Asn Phe Ala Met Ala 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Asp Tyr Ala Met Val 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Asp Phe Pro Met Ala 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  38

Ile Asn Tyr Trp Asp 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Asn Phe Pro Met Ala 
1               5   


<210>  40
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Ser Ile Ser Tyr Asp Gly Val Asn Thr Tyr Tyr Arg Asp 
1               5                   10              


<210>  41
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  41

Thr Ile Thr Tyr Asp Gly Ser Arg Ile Tyr Tyr Arg Asp 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  42

Thr Ile Ser Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Gly 
1               5                   10              


<210>  43
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  43

His Ile Asn Tyr Ser Gly Gly Thr Asn Tyr Asn Pro 
1               5                   10          


<210>  44
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  44

Val Val Ser Ile Ser Gly Gly Ala Thr Tyr Tyr Arg Asp 
1               5                   10              


<210>  45
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  45

Arg Gly Ala Ala Pro Phe Asp Phe 
1               5               


<210>  46
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  46

Gln Gly Gly Tyr Thr Thr Asp Tyr Tyr Tyr Val Met Asp Ala 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  47

Pro Leu Tyr Tyr Ser Asn Tyr Val Gly Asn Val Met Asp Ala 
1               5                   10                  


<210>  48
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  48

Glu Gly Ala Gly Gly Leu Asp Tyr 
1               5               


<210>  49
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Gly Asp Gly Ser Ser Arg Gly Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  50
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  51

Gly Thr Ser Lys Leu Ala Ser Gly Val Pro Asn 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Tyr Ala Ser Thr Arg Gln Ser Gly Val Pro Asp 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  53

Glu Gly Ser Asn Leu Pro Ser Gly Ile Pro Ala 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  54

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Asn 
1               5                   10      


<210>  55
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Ser Ile Ser Tyr Asp Gly Val Asn Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  56

Thr Ile Thr Tyr Asp Gly Ser Arg Ile Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Thr Ile Ser Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Gly Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  58

His Ile Asn Tyr Ser Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  59
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  59

Val Val Ser Ile Ser Gly Gly Ala Thr Tyr Tyr Arg Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


