                         SEQUENCE LISTING

<110>  Sorbonne Universit
       Centre Hospitalier National d'Ophtalmologie Quinze-Vingts
       Centre National de la Recherche Scientifique
       INSERM - Institut National de la Sant et de la Recherche 
       Mdicale
       Ruhr-Universitt Bochum
       DALKARA, Deniz
       AUDO, Isabelle
       PICAUD, Serge
       BERTIN, Stphane
       HERLITZE, Stefan
       SAHEL, Jos-Alain
       SIMON, Cardillia-Joe
 
<120>  G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT 
       SENSITIVITY IN ROD-CONE DYSTROPHY (RCD)

<130>  BNT228412PC00

<150>  EP20315148.5
<151>  2020-04-10

<150>  EP20305734.4
<151>  2020-06-30

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1269
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1269)

<400>  1
atg gcc aag ctg aca gaa tcc atg act aac gtc ctg gag ggc gac tcc         48
Met Ala Lys Leu Thr Glu Ser Met Thr Asn Val Leu Glu Gly Asp Ser           
1               5                   10                  15                

atg gat cag gac gtc gaa agc cca gtg gcc att cac cag cca aag ttg         96
Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro Lys Leu           
            20                  25                  30                    

cct aag cag gcc agg gat gac ctg cca aga cac atc agc cga gat cgg        144
Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg Asp Arg           
        35                  40                  45                        

acc aaa agg aaa atc cag agg tac gtg agg aaa gac gga aag tgc aat        192
Thr Lys Arg Lys Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys Cys Asn           
    50                  55                  60                            

gtt cat cac ggc aac gtg agg gag acc tat cgc tac ctg acc gat atc        240
Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Ile           
65                  70                  75                  80            

ttc acc aca tta gtg gac ctg aag tgg aga ttc aac cta ttg att ttt        288
Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Ile Phe           
                85                  90                  95                

gtc atg gtt tac aca gtg acc tgg ctc ttt ttt gga atg atc tgg tgg        336
Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile Trp Trp           
            100                 105                 110                   

ttg atc gca tac ata cgg gga gac atg gac cac ata gag gac ccc tcc        384
Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp Pro Ser           
        115                 120                 125                       

tgg act cct tgt gtt acc aac ctc aac ggg ttc gtc tct gct ttt tta        432
Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala Phe Leu           
    130                 135                 140                           

ttc tca ata gag aca gaa acc acc att ggt tat ggc tac cgg gtc atc        480
Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg Val Ile           
145                 150                 155                 160           

aca gat aaa tgc cca gag gga att att ctt ctc tta atc caa tct gtg        528
Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln Ser Val           
                165                 170                 175               

ttg ggg tcc att gtc aat gca ttc atg gtg gga tgc atg ttt gta aaa        576
Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys           
            180                 185                 190                   

atc tct caa ccc aag aag agg gca gag acc ctg gtc ttt tcc acc cat        624
Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser Thr His           
        195                 200                 205                       

gca gtg atc tcc atg cgg gat ggg aaa ctg tgc ctg atg ttc cgg gta        672
Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe Arg Val           
    210                 215                 220                           

ggg gac ctt agg aat tcc cac att gtg gag gct tcc atc aga gcc aag        720
Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys           
225                 230                 235                 240           

ttg atc aaa tcc aaa cag acc tcg gag ggg gag ttc atc ccg ttg aac        768
Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro Leu Asn           
                245                 250                 255               

cag acg gat atc aac gta ggg tat tac acg ggg gat gac cgt ctg ttt        816
Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg Leu Phe           
            260                 265                 270                   

ctg gtg tca ccg ctg atc att agc cat gaa att aac caa cag agt cct        864
Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln Ser Pro           
        275                 280                 285                       

ttc tgg gag atc tcc aaa gcc cag ctg ccc aaa gag gaa ctg gaa att        912
Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu Glu Ile           
    290                 295                 300                           

gtg gtc atc cta gaa gga atg gtg gaa gcc aca ggg atg aca tgc caa        960
Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln           
305                 310                 315                 320           

gct cga agc tcc tac atc acc agt gag atc ctg tgg ggt tac cgg ttc       1008
Ala Arg Ser Ser Tyr Ile Thr Ser Glu Ile Leu Trp Gly Tyr Arg Phe           
                325                 330                 335               

aca cct gtc ctg acc ctg gag gac ggg ttc tac gaa gtt gac tac aac       1056
Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Asn           
            340                 345                 350                   

agc ttc cat gag acc tat gag acc agc acc cca tcc ctt agt gcc aaa       1104
Ser Phe His Glu Thr Tyr Glu Thr Ser Thr Pro Ser Leu Ser Ala Lys           
        355                 360                 365                       

gag ctg gcc gag tta gcc agc agg gca gag ctg ccc ctg agt tgg tct       1152
Glu Leu Ala Glu Leu Ala Ser Arg Ala Glu Leu Pro Leu Ser Trp Ser           
    370                 375                 380                           

gta tcc agc aaa ctc aac caa cat gca gaa ctg gag act gaa gag gaa       1200
Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu Glu Glu           
385                 390                 395                 400           

gaa aag aac ctc gaa gag caa aca gaa aga aat ggt gat gtg gca aac       1248
Glu Lys Asn Leu Glu Glu Gln Thr Glu Arg Asn Gly Asp Val Ala Asn           
                405                 410                 415               

ctg gag aat gaa tcc aaa gtt                                           1269
Leu Glu Asn Glu Ser Lys Val                                               
            420                                                           


<210>  2
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Lys Leu Thr Glu Ser Met Thr Asn Val Leu Glu Gly Asp Ser 
1               5                   10                  15      


Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro Lys Leu 
            20                  25                  30          


Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg Asp Arg 
        35                  40                  45              


Thr Lys Arg Lys Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys Cys Asn 
    50                  55                  60                  


Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Ile 
65                  70                  75                  80  


Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Ile Phe 
                85                  90                  95      


Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile Trp Trp 
            100                 105                 110         


Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp Pro Ser 
        115                 120                 125             


Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala Phe Leu 
    130                 135                 140                 


Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg Val Ile 
145                 150                 155                 160 


Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln Ser Val 
                165                 170                 175     


Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys 
            180                 185                 190         


Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser Thr His 
        195                 200                 205             


Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe Arg Val 
    210                 215                 220                 


Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys 
225                 230                 235                 240 


Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro Leu Asn 
                245                 250                 255     


Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg Leu Phe 
            260                 265                 270         


Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln Ser Pro 
        275                 280                 285             


Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu Glu Ile 
    290                 295                 300                 


Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln 
305                 310                 315                 320 


Ala Arg Ser Ser Tyr Ile Thr Ser Glu Ile Leu Trp Gly Tyr Arg Phe 
                325                 330                 335     


Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Asn 
            340                 345                 350         


Ser Phe His Glu Thr Tyr Glu Thr Ser Thr Pro Ser Leu Ser Ala Lys 
        355                 360                 365             


Glu Leu Ala Glu Leu Ala Ser Arg Ala Glu Leu Pro Leu Ser Trp Ser 
    370                 375                 380                 


Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu Glu Glu 
385                 390                 395                 400 


Glu Lys Asn Leu Glu Glu Gln Thr Glu Arg Asn Gly Asp Val Ala Asn 
                405                 410                 415     


Leu Glu Asn Glu Ser Lys Val 
            420             


<210>  3
<211>  1275
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(1275)

<400>  3
atg aca atg gcc aag tta act gaa tcc atg act aac gcc gcc gaa ggc         48
Met Thr Met Ala Lys Leu Thr Glu Ser Met Thr Asn Ala Ala Glu Gly           
1               5                   10                  15                

gat tcc atg gac cag gat gtg gaa agc cca gtg gcc att cac cag cca         96
Asp Ser Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro           
            20                  25                  30                    

aag ttg cct aag cag gcc agg gac gac ctg ccg aga cac atc agc cga        144
Lys Leu Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg           
        35                  40                  45                        

gac agg acc aaa agg aaa atc cag agg tac gtg agg aag gat ggg aag        192
Asp Arg Thr Lys Arg Lys Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys           
    50                  55                  60                            

tgc aac gtt cac cac ggc aat gtg cgg gag acg tac cga tac ctg acg        240
Cys Asn Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr           
65                  70                  75                  80            

gac atc ttc acc acc ctg gtg gac ctg aag tgg aga ttc aac ctg ttg        288
Asp Ile Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu           
                85                  90                  95                

atc ttt gtc atg gtc tac aca gtg acg tgg ctt ttc ttt ggg atg atc        336
Ile Phe Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile           
            100                 105                 110                   

tgg tgg ctg att gcg tac atc cgg gga gat atg gac cac ata gag gac        384
Trp Trp Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp           
        115                 120                 125                       

ccc tcg tgg act cct tgt gtc acc aac ctc aac ggg ttt gtc tct gct        432
Pro Ser Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala           
    130                 135                 140                           

ttt tta ttc tcc ata gag aca gaa acc acc atc ggt tat ggc tac cgg        480
Phe Leu Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg           
145                 150                 155                 160           

gtc atc acg gac aag tgc cct gag ggg att att ctc ctc tta atc cag        528
Val Ile Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln           
                165                 170                 175               

tcc gtg ttg ggg tcc att gtc aac gcc ttc atg gta gga tgt atg ttt        576
Ser Val Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe           
            180                 185                 190                   

gtg aaa ata tcc caa ccc aag aag agg gca gag acc ctg gtc ttt tcc        624
Val Lys Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser           
        195                 200                 205                       

acc cac gcg gtg atc tcc atg cgg gat ggg aaa ctg tgc ttg atg ttc        672
Thr His Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe           
    210                 215                 220                           

cgg gtg ggg gac ttg agg aat tct cac att gtg gag gca tcc atc aga        720
Arg Val Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg           
225                 230                 235                 240           

gcc aag ttg atc aag tcc aaa cag act tca gag ggg gag ttt att ccc        768
Ala Lys Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro           
                245                 250                 255               

ctc aac cag act gat atc aac gtg ggg tac tac aca ggg gac gac cgg        816
Leu Asn Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg           
            260                 265                 270                   

ctc ttt ctg gtg tca cca ttg att att agc cat gaa att aac caa cag        864
Leu Phe Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln           
        275                 280                 285                       

agt ccc ttc tgg gag atc tcc aaa gcg cag ctg cct aaa gag gaa ctg        912
Ser Pro Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu           
    290                 295                 300                           

gag att gtg gtc atc ctg gag gga atg gtg gaa gcc aca gga atg acg        960
Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr           
305                 310                 315                 320           

tgc caa gcc cga agc tcc tac atc acc agt gag atc ttg tgg ggt tac       1008
Cys Gln Ala Arg Ser Ser Tyr Ile Thr Ser Glu Ile Leu Trp Gly Tyr           
                325                 330                 335               

cgg ttc aca cct gtc cta acg ctg gaa gac ggg ttc tac gaa gtt gac       1056
Arg Phe Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp           
            340                 345                 350                   

tac aac agc ttc cat gag acc tat gag acc agc acc ccg tcc ctt agt       1104
Tyr Asn Ser Phe His Glu Thr Tyr Glu Thr Ser Thr Pro Ser Leu Ser           
        355                 360                 365                       

gcc aaa gag cta gcg gag ctg gct aac cgg gca gag ctg cct ctg agt       1152
Ala Lys Glu Leu Ala Glu Leu Ala Asn Arg Ala Glu Leu Pro Leu Ser           
    370                 375                 380                           

tgg tct gtg tcc agc aaa ctg aac caa cat gca gaa ttg gag aca gaa       1200
Trp Ser Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu           
385                 390                 395                 400           

gag gaa gag aag aac ccg gaa gaa ctg acg gag agg aat ggt gac gtg       1248
Glu Glu Glu Lys Asn Pro Glu Glu Leu Thr Glu Arg Asn Gly Asp Val           
                405                 410                 415               

gca aac cta gag aat gaa tcc aaa gtt                                   1275
Ala Asn Leu Glu Asn Glu Ser Lys Val                                       
            420                 425                                       


<210>  4
<211>  425
<212>  PRT
<213>  Mus musculus

<400>  4

Met Thr Met Ala Lys Leu Thr Glu Ser Met Thr Asn Ala Ala Glu Gly 
1               5                   10                  15      


Asp Ser Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro 
            20                  25                  30          


Lys Leu Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg 
        35                  40                  45              


Asp Arg Thr Lys Arg Lys Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys 
    50                  55                  60                  


Cys Asn Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr 
65                  70                  75                  80  


Asp Ile Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu 
                85                  90                  95      


Ile Phe Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile 
            100                 105                 110         


Trp Trp Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp 
        115                 120                 125             


Pro Ser Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala 
    130                 135                 140                 


Phe Leu Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg 
145                 150                 155                 160 


Val Ile Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln 
                165                 170                 175     


Ser Val Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe 
            180                 185                 190         


Val Lys Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser 
        195                 200                 205             


Thr His Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe 
    210                 215                 220                 


Arg Val Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg 
225                 230                 235                 240 


Ala Lys Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro 
                245                 250                 255     


Leu Asn Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg 
            260                 265                 270         


Leu Phe Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln 
        275                 280                 285             


Ser Pro Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu 
    290                 295                 300                 


Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr 
305                 310                 315                 320 


Cys Gln Ala Arg Ser Ser Tyr Ile Thr Ser Glu Ile Leu Trp Gly Tyr 
                325                 330                 335     


Arg Phe Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp 
            340                 345                 350         


Tyr Asn Ser Phe His Glu Thr Tyr Glu Thr Ser Thr Pro Ser Leu Ser 
        355                 360                 365             


Ala Lys Glu Leu Ala Glu Leu Ala Asn Arg Ala Glu Leu Pro Leu Ser 
    370                 375                 380                 


Trp Ser Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu 
385                 390                 395                 400 


Glu Glu Glu Lys Asn Pro Glu Glu Leu Thr Glu Arg Asn Gly Asp Val 
                405                 410                 415     


Ala Asn Leu Glu Asn Glu Ser Lys Val 
            420                 425 


<210>  5
<211>  1221
<212>  DNA
<213>  Rattus rattus


<220>
<221>  CDS
<222>  (1)..(1221)

<400>  5
atg gac caa gac gtg gaa agc cca gtg gcc att cac cag cca aag ttg         48
Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro Lys Leu           
1               5                   10                  15                

cct aag cag gcc agg gat gac ctg cca aga cac atc agc cga gac agg         96
Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg Asp Arg           
            20                  25                  30                    

acc aaa agg aga atc cag agg tac gtg agg aag gat ggg aag tgt aac        144
Thr Lys Arg Arg Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys Cys Asn           
        35                  40                  45                        

gtc cac cac ggc aac gtg cgg gag acg tac cga tac ctg acg gac atc        192
Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Ile           
    50                  55                  60                            

ttc acc acc ctg gtg gac cta aag tgg aga ttc aac cta ttg atc ttt        240
Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Ile Phe           
65                  70                  75                  80            

gtc atg gtc tac aca gtg acg tgg ctt ttc ttt ggg atg atc tgg tgg        288
Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile Trp Trp           
                85                  90                  95                

cta att gca tac atc cgg gga gat atg gac cac ata gag gac ccc tcg        336
Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp Pro Ser           
            100                 105                 110                   

tgg act ccc tgt gtt acc aac ctc aac ggg ttt gtc tcc gct ttt tta        384
Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala Phe Leu           
        115                 120                 125                       

ttc tca ata gag aca gaa acc acc att ggt tat ggc tac agg gtc atc        432
Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg Val Ile           
    130                 135                 140                           

acg gac aag tgc cca gaa gga att att ctc ctc tta atc cag tcc gtg        480
Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln Ser Val           
145                 150                 155                 160           

ttg ggg tcc att gtc aac gcc ttc atg gta gga tgt atg ttt gtg aaa        528
Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys           
                165                 170                 175               

ata tcc caa ccc aag aag agg gca gag acc ctg gtc ttt tcc acc cat        576
Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser Thr His           
            180                 185                 190                   

gcg gta atc tcc atg cgg gat ggg aaa cta tgc ctg atg ttc cgg gta        624
Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe Arg Val           
        195                 200                 205                       

ggg gac ttg agg aat tcc cac att gtg gag gcc tcc atc aga gcc aag        672
Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys           
    210                 215                 220                           

ttg atc aag tcc aaa cag act tca gag ggg gag ttc att ccc ctc aac        720
Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro Leu Asn           
225                 230                 235                 240           

cag acg gat atc aac gta ggg tac tac acc ggg gat gac cga ctc ttt        768
Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg Leu Phe           
                245                 250                 255               

ctc gtg tca ccg ctg att att agc cat gaa att aac caa cag agt ccc        816
Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln Ser Pro           
            260                 265                 270                   

ttc tgg gag atc tcc aaa gcc cag ctg cct aaa gag gaa ctg gag att        864
Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu Glu Ile           
        275                 280                 285                       

gtg gtc atc ctg gag gga atg gtg gaa gcc aca gga atg acg tgc caa        912
Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln           
    290                 295                 300                           

gct cga agc tcc tac gtc acc agt gag atc ctg tgg ggt tac cgg ttc        960
Ala Arg Ser Ser Tyr Val Thr Ser Glu Ile Leu Trp Gly Tyr Arg Phe           
305                 310                 315                 320           

aca cca gtc ctg aca ctg gag gac ggg ttc tat gaa gtt gac tac aac       1008
Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Asn           
                325                 330                 335               

agc ttc cat gag acc cat gag acc agc acc ccg tcc ctt agc gcc aaa       1056
Ser Phe His Glu Thr His Glu Thr Ser Thr Pro Ser Leu Ser Ala Lys           
            340                 345                 350                   

gag cta gcc gag ctg gct aac cgg gca gag ctg ccc ctg agc tgg tct       1104
Glu Leu Ala Glu Leu Ala Asn Arg Ala Glu Leu Pro Leu Ser Trp Ser           
        355                 360                 365                       

gtg tcc agc aaa ctg aac caa cat gca gaa ctg gag acg gaa gag gaa       1152
Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu Glu Glu           
    370                 375                 380                           

gag aag aac ccg gaa gaa ctg aca gag agg aat ggt gat gtg gca aac       1200
Glu Lys Asn Pro Glu Glu Leu Thr Glu Arg Asn Gly Asp Val Ala Asn           
385                 390                 395                 400           

cta gag aat gag tcc aaa gtg                                           1221
Leu Glu Asn Glu Ser Lys Val                                               
                405                                                       


<210>  6
<211>  407
<212>  PRT
<213>  Rattus rattus

<400>  6

Met Asp Gln Asp Val Glu Ser Pro Val Ala Ile His Gln Pro Lys Leu 
1               5                   10                  15      


Pro Lys Gln Ala Arg Asp Asp Leu Pro Arg His Ile Ser Arg Asp Arg 
            20                  25                  30          


Thr Lys Arg Arg Ile Gln Arg Tyr Val Arg Lys Asp Gly Lys Cys Asn 
        35                  40                  45              


Val His His Gly Asn Val Arg Glu Thr Tyr Arg Tyr Leu Thr Asp Ile 
    50                  55                  60                  


Phe Thr Thr Leu Val Asp Leu Lys Trp Arg Phe Asn Leu Leu Ile Phe 
65                  70                  75                  80  


Val Met Val Tyr Thr Val Thr Trp Leu Phe Phe Gly Met Ile Trp Trp 
                85                  90                  95      


Leu Ile Ala Tyr Ile Arg Gly Asp Met Asp His Ile Glu Asp Pro Ser 
            100                 105                 110         


Trp Thr Pro Cys Val Thr Asn Leu Asn Gly Phe Val Ser Ala Phe Leu 
        115                 120                 125             


Phe Ser Ile Glu Thr Glu Thr Thr Ile Gly Tyr Gly Tyr Arg Val Ile 
    130                 135                 140                 


Thr Asp Lys Cys Pro Glu Gly Ile Ile Leu Leu Leu Ile Gln Ser Val 
145                 150                 155                 160 


Leu Gly Ser Ile Val Asn Ala Phe Met Val Gly Cys Met Phe Val Lys 
                165                 170                 175     


Ile Ser Gln Pro Lys Lys Arg Ala Glu Thr Leu Val Phe Ser Thr His 
            180                 185                 190         


Ala Val Ile Ser Met Arg Asp Gly Lys Leu Cys Leu Met Phe Arg Val 
        195                 200                 205             


Gly Asp Leu Arg Asn Ser His Ile Val Glu Ala Ser Ile Arg Ala Lys 
    210                 215                 220                 


Leu Ile Lys Ser Lys Gln Thr Ser Glu Gly Glu Phe Ile Pro Leu Asn 
225                 230                 235                 240 


Gln Thr Asp Ile Asn Val Gly Tyr Tyr Thr Gly Asp Asp Arg Leu Phe 
                245                 250                 255     


Leu Val Ser Pro Leu Ile Ile Ser His Glu Ile Asn Gln Gln Ser Pro 
            260                 265                 270         


Phe Trp Glu Ile Ser Lys Ala Gln Leu Pro Lys Glu Glu Leu Glu Ile 
        275                 280                 285             


Val Val Ile Leu Glu Gly Met Val Glu Ala Thr Gly Met Thr Cys Gln 
    290                 295                 300                 


Ala Arg Ser Ser Tyr Val Thr Ser Glu Ile Leu Trp Gly Tyr Arg Phe 
305                 310                 315                 320 


Thr Pro Val Leu Thr Leu Glu Asp Gly Phe Tyr Glu Val Asp Tyr Asn 
                325                 330                 335     


Ser Phe His Glu Thr His Glu Thr Ser Thr Pro Ser Leu Ser Ala Lys 
            340                 345                 350         


Glu Leu Ala Glu Leu Ala Asn Arg Ala Glu Leu Pro Leu Ser Trp Ser 
        355                 360                 365             


Val Ser Ser Lys Leu Asn Gln His Ala Glu Leu Glu Thr Glu Glu Glu 
    370                 375                 380                 


Glu Lys Asn Pro Glu Glu Leu Thr Glu Arg Asn Gly Asp Val Ala Asn 
385                 390                 395                 400 


Leu Glu Asn Glu Ser Lys Val 
                405         


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion peptide

<400>  7

Leu Gly Glu Thr Thr Arg Pro 
1               5           


<210>  8
<211>  732
<212>  PRT
<213>  adeno-associated virus 9


<220>
<221>  PEPTIDE
<222>  (1)..(732)
<223>  wild-type AAV9 VP1 capsid protein

<400>  8

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Gln Ala Gln Thr Gly 
            580                 585                 590         


Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro 
                645                 650                 655     


Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr 
    690                 695                 700                 


Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730         


<210>  9
<211>  735
<212>  PRT
<213>  adeno-associated virus 2


<220>
<221>  PEPTIDE
<222>  (1)..(735)
<223>  wild-type AAV2 VP1 capsid protein

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion peptide

<400>  10

Ala Ala Leu Gly Glu Thr Thr Arg Pro Ala 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion peptide

<400>  11

Leu Ala Leu Gly Glu Thr Thr Arg Pro Ala 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insertion peptide

<400>  12

Gly Leu Gly Glu Thr Thr Arg Pro Ala 
1               5                   


<210>  13
<211>  1724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pR1.7 promoter

<400>  13
ggaggctgag gggtggggaa agggcatggg tgtttcatga ggacagagct tccgtttcat       60

gcaatgaaaa gagtttggag acggatggtg gtgactggac tatacactta cacacggtag      120

cgatggtaca ctttgtatta tgtatatttt accacgatct ttttaaagtg tcaaaggcaa      180

atggccaaat ggttccttgt cctatagctg tagcagccat cggctgttag tgacaaagcc      240

cctgagtcaa gatgacagca gcccccataa ctcctaatcg gctctcccgc gtggagtcat      300

ttaggagtag tcgcattaga gacaagtcca acatctaatc ttccaccctg gccagggccc      360

cagctggcag cgagggtggg agactccggg cagagcagag ggcgctgaca ttggggcccg      420

gcctggcttg ggtccctctg gcctttcccc aggggccctc tttccttggg gctttcttgg      480

gccgccactg ctcccgctcc tctcccccca tcccaccccc tcaccccctc gttcttcata      540

tccttctcta gtgctccctc cactttcatc cacccttctg caagagtgtg ggaccacaaa      600

tgagttttca cctggcctgg ggacacacgt gcccccacag gtgctgagtg actttctagg      660

acagtaatct gctttaggct aaaatgggac ttgatcttct gttagcccta atcatcaatt      720

agcagagccg gtgaaggtgc agaacctacc gcctttccag gcctcctccc acctctgcca      780

cctccactct ccttcctggg atgtgggggc tggcacacgt gtggcccagg gcattggtgg      840

gattgcactg agctgggtca ttagcgtaat cctggacaag ggcagacagg gcgagcggag      900

ggccagctcc ggggctcagg caaggctggg ggcttccccc agacacccca ctcctcctct      960

gctggacccc cacttcatag ggcacttcgt gttctcaaag ggcttccaaa tagcatggtg     1020

gccttggatg cccagggaag cctcagagtt gcttatctcc ctctagacag aaggggaatc     1080

tcggtcaaga gggagaggtc gccctgttca aggccaccca gccagctcat ggcggtaatg     1140

ggacaaggct ggccagccat cccaccctca gaagggaccc ggtggggcag gtgatctcag     1200

aggaggctca cttctgggtc tcacattctt ggatccggtt ccaggcctcg gccctaaata     1260

gtctccctgg gctttcaaga gaaccacatg agaaaggagg attcgggctc tgagcagttt     1320

caccacccac cccccagtct gcaaatcctg acccgtgggt ccacctgccc caaaggcgga     1380

cgcaggacag tagaagggaa cagagaacac ataaacacag agagggccac agcggctccc     1440

acagtcaccg ccaccttcct ggcggggatg ggtggggcgt ctgagtttgg ttcccagcaa     1500

atccctctga gccgcccttg cgggctcgcc tcaggagcag gggagcaaga ggtgggagga     1560

ggaggtctaa gtcccaggcc caattaagag atcaggtagt gtagggtttg ggagctttta     1620

aggtgaagag gcccgggctg atcccacagg ccagtataaa gcgccgtgac cctcaggtga     1680

tgcgccaggg ccggctgccg tcggggacag ggctttccat agcc                      1724


<210>  14
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  minimal M-opsin promoter region

<400>  14
ccagcaaatc cctctgagcc gcccccgggg gctcgcctca ggagcaagga agcaaggggt       60

gggaggagga ggtctaagtc ccaggcccaa ttaagagatc agatggtgta ggatttggga      120

gcttttaagg tgaagaggcc cgggctgatc ccactggccg gtataaagca ccgtgaccct      180

caggtgacgc accagggccg gctgccgtcg gggacagggc tttccatagc ccag            234


<210>  15
<211>  1958
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMNTC

<400>  15
cctacagcag ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt       60

agggggcctt ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg      120

cgtttacgga cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat      180

gtttaaccac acaaaaatga aaatccaatg gttggatatc cattccaaat acacaaaggc      240

aacggataag tgatccgggc caggcacaga aggccatgca cccgtaggat tgcactcaga      300

gctcccaaat gcataggaat agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc      360

atgggtgttt catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga      420

tggtggtgac tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat      480

attttaccac gatcttttta aagtgtcaaa ggcaaatggc caaatggttc cttgtcctat      540

agctgtagca gccatcggct gttagtgaca aagcccctga gtcaagatga cagcagcccc      600

cataactcct aatcggctct cccgcgtgga gtcatttagg agtagtcgca ttagagacaa      660

gtccaacatc taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact      720

ccgggcagag cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt      780

tccccagggg ccctctttcc ttggggcttt cttgggccgc cactgctccc gctcctctcc      840

ccccatccca ccccctcacc ccctcgttct tcatatcctt ctctagtgct ccctccactt      900

tcatccaccc ttctgcaaga gtgtgggacc acaaatgagt tttcacctgg cctggggaca      960

cacgtgcccc cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat     1020

gggacttgat cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac     1080

ctaccgcctt tccaggcctc ctcccacctc tgccacctcc actctccttc ctgggatgtg     1140

ggggctggca cacgtgtggc ccagggcatt ggtgggattg cactgagctg ggtcattagc     1200

gtaatcctgg acaagggcag acagggcgag cggagggcca gctccggggc tcaggcaagg     1260

ctgggggctt cccccagaca ccccactcct cctctgctgg acccccactt catagggcac     1320

ttcgtgttct caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca     1380

gagttgctta tctccctcta gacagaaggg gaatctcggt caagagggag aggtcgccct     1440

gttcaaggcc acccagccag ctcatggcgg taatgggaca aggctggcca gccatcccac     1500

cctcagaagg gacccggtgg ggcaggtgat ctcagaggag gctcacttct gggtctcaca     1560

ttcttccagc aaatccctct gagccgcccc cgggggctcg cctcaggagc aaggaagcaa     1620

ggggtgggag gaggaggtct aagtcccagg cccaattaag agatcagatg gtgtaggatt     1680

tgggagcttt taaggtgaag aggcccgggc tgatcccact ggccggtata aagcaccgtg     1740

accctcaggt gacgcaccag ggccggctgc cgtcggggac agggctttcc atagcccagg     1800

taagtatcaa ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac     1860

agagaagact cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct     1920

ttctctccac aggcccagag aggagacagg ccgccacc                             1958


<210>  16
<211>  410
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(410)
<223>  long wave sensitive opsin 1 (OPN1LW)

<400>  16

Met Val Leu Lys Ala Glu His Thr Arg Ser Pro Ser Ala Thr Leu Pro 
1               5                   10                  15      


Ser Asn Val Pro Ser Cys Arg Ser Leu Ser Ser Ser Glu Asp Gly Pro 
            20                  25                  30          


Ser Gly Pro Ser Ser Leu Ala Asp Gly Gly Leu Ala His Asn Leu Gln 
        35                  40                  45              


Asp Ser Val Arg His Arg Ile Leu Tyr Leu Ser Glu Gln Leu Arg Val 
    50                  55                  60                  


Glu Lys Ala Ser Arg Asp Gly Asn Thr Val Ser Tyr Leu Lys Leu Val 
65                  70                  75                  80  


Ser Lys Ala Asp Arg His Gln Val Pro His Ile Gln Gln Ala Phe Glu 
                85                  90                  95      


Lys Val Asn Gln Arg Ala Ser Ala Thr Ile Ala Gln Ile Glu His Arg 
            100                 105                 110         


Leu His Gln Cys His Gln Gln Leu Gln Glu Leu Glu Glu Gly Cys Arg 
        115                 120                 125             


Pro Glu Gly Leu Leu Leu Met Ala Glu Ser Asp Pro Ala Asn Cys Glu 
    130                 135                 140                 


Pro Pro Ser Glu Lys Ala Leu Leu Ser Glu Pro Pro Glu Pro Gly Gly 
145                 150                 155                 160 


Glu Asp Gly Pro Val Asn Leu Pro His Ala Ser Arg Pro Phe Ile Leu 
                165                 170                 175     


Glu Ser Arg Phe Gln Ser Leu Gln Gln Gly Thr Cys Leu Glu Thr Glu 
            180                 185                 190         


Asp Val Ala Gln Gln Gln Asn Leu Leu Leu Gln Lys Val Lys Ala Glu 
        195                 200                 205             


Leu Glu Glu Ala Lys Arg Phe His Ile Ser Leu Gln Glu Ser Tyr His 
    210                 215                 220                 


Ser Leu Lys Glu Arg Ser Leu Thr Asp Leu Gln Leu Leu Leu Glu Ser 
225                 230                 235                 240 


Leu Gln Glu Glu Lys Cys Arg Gln Ala Leu Met Glu Glu Gln Val Asn 
                245                 250                 255     


Gly Arg Leu Gln Gly Gln Leu Asn Glu Ile Tyr Asn Leu Lys His Asn 
            260                 265                 270         


Leu Ala Cys Ser Glu Glu Arg Met Ala Tyr Leu Ser Tyr Glu Arg Ala 
        275                 280                 285             


Lys Glu Ile Trp Glu Ile Thr Glu Thr Phe Lys Ser Arg Ile Ser Lys 
    290                 295                 300                 


Leu Glu Met Leu Gln Gln Val Thr Gln Leu Glu Ala Ala Glu His Leu 
305                 310                 315                 320 


Gln Ser Arg Pro Pro Gln Met Leu Phe Lys Phe Leu Ser Pro Arg Leu 
                325                 330                 335     


Ser Leu Ala Thr Val Leu Leu Val Phe Val Ser Thr Leu Cys Ala Cys 
            340                 345                 350         


Pro Ser Ser Leu Ile Ser Ser Arg Leu Cys Thr Cys Thr Met Leu Met 
        355                 360                 365             


Leu Ile Gly Leu Gly Val Leu Ala Trp Gln Arg Trp Arg Ala Ile Pro 
    370                 375                 380                 


Ala Thr Asp Trp Gln Glu Trp Val Pro Ser Arg Cys Arg Leu Tyr Ser 
385                 390                 395                 400 


Lys Asp Ser Gly Pro Pro Ala Asp Gly Pro 
                405                 410 


