﻿                         序列表

<110>  北京卡替医疗技术有限公司

<120>  一种转染抗原基因的细胞疫苗及相关免疫细胞

<130>  PR12816CMT33WO

<150>  CN202010269944.4
<151>  2020-04-08

<160>  12

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1773
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  1
tctagagcca ccatgcgggt cacggcgccc cgaaccgtcc tcctgctgct ctcggcggcc        60
ctggccctga ccgagacctg ggccatgtct ctttggctgc ctagtgaggc cactgtctac       120
ttgcctcctg tcccagtatc taaggttgta agcacggatg aatatgttgc acgcacaaac       180
atatattatc atgcaggaac atccagacta cttgcagttg gacatcccta ttttcctatt       240
aaaaaaccta acaataacaa aatattagtt cctaaagtat caggattaca atacagggta       300
tttagaatac atttacctga ccccaataag tttggttttc ctgacacctc attttataat       360
ccagatacac agcggctggt ttgggcctgt gtaggtgttg aggtaggtcg tggtcagcca       420
ttaggtgtgg gcattagtgg ccatccttta ttaaataaat tggatgacac agaaaatgct       480
agtgcttatg cagcaaatgc aggtgtggat aatagagaat gtatatctat ggattacaaa       540
caaacacaat tgtgtttaat tggttgcaaa ccacctatag gggaacactg gggcaaagga       600
tccccatgta ccaatgttgc agtaaatcca ggtgattgtc caccattaga gttaataaac       660
acagttattc aggatggtga tatggttgat actggctttg gtgctatgga ctttactaca       720
ttacaggcta acaaaagtga agttccactg gatatttgta catctatttg caaatatcca       780
gattatatta aaatggtgtc agaaccatat ggcgacagct tattttttta tttacgaagg       840
gaacaaatgt ttgttagaca tttatttaat agggctggta ctgttggtga aaatgtacca       900
gacgatttat acattaaagg ctctgggtct actgcaaatt tagccagttc aaattatttt       960
cctacaccta gtggttctat ggttacctct gatgcccaaa tattcaataa accttattgg      1020
ttacaacgag cacagggcca caataatggc atttgttggg gtaaccaact atttgttact      1080
gttgttgata ctacacgcag tacaaatatg tcattatgtg ctgccatatc tacttcagaa      1140
actacatata aaaatactaa ctttaaggag tacctacgac atggggagga atatgattta      1200
cagtttattt ttcaactgtg caaaataacc ttaactgcag acgttatgac atacatacat      1260
tctatgaatt ccactatttt ggaggactgg aattttggtc tacaacctcc cccaggaggc      1320
acactagaag atacttatag gtttgtaaca tcccaggcaa ttgcttgtca aaaacataca      1380
cctccagcac ctaaagaaga tccccttaaa aaatacactt tttgggaagt aaatttaaag      1440
gaaaagtttt ctgcagacct agatcagttt cctttaggac gcaaattttt actacaagca      1500
ggattgaagg ccaaaccaaa atttacatta ggaaaacgaa aagctacacc caccacctca      1560
tctacctcta caactgctaa acgcaaaaaa cgtaagctga tcgtgggcat tgttgctggc      1620
ctggctgtcc tagcagttgt ggtcatcgga gctgtggtcg ctgctgtgat gtgtaggagg      1680
aagagttcag gtggaaaagg agggagctac tctcaggctg cgtgcagcga cagtgcccag      1740
ggctctgatg tgtctctcac agcttaagtc gac                                   1773

<210>  2
<211>  584
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Met Ser Leu Trp Leu Pro Ser Glu 
            20                  25                  30          
Ala Thr Val Tyr Leu Pro Pro Val Pro Val Ser Lys Val Val Ser Thr 
        35                  40                  45              
Asp Glu Tyr Val Ala Arg Thr Asn Ile Tyr Tyr His Ala Gly Thr Ser 
    50                  55                  60                  
Arg Leu Leu Ala Val Gly His Pro Tyr Phe Pro Ile Lys Lys Pro Asn 
65                  70                  75                  80  
Asn Asn Lys Ile Leu Val Pro Lys Val Ser Gly Leu Gln Tyr Arg Val 
                85                  90                  95      
Phe Arg Ile His Leu Pro Asp Pro Asn Lys Phe Gly Phe Pro Asp Thr 
            100                 105                 110         
Ser Phe Tyr Asn Pro Asp Thr Gln Arg Leu Val Trp Ala Cys Val Gly 
        115                 120                 125             
Val Glu Val Gly Arg Gly Gln Pro Leu Gly Val Gly Ile Ser Gly His 
    130                 135                 140                 
Pro Leu Leu Asn Lys Leu Asp Asp Thr Glu Asn Ala Ser Ala Tyr Ala 
145                 150                 155                 160 
Ala Asn Ala Gly Val Asp Asn Arg Glu Cys Ile Ser Met Asp Tyr Lys 
                165                 170                 175     
Gln Thr Gln Leu Cys Leu Ile Gly Cys Lys Pro Pro Ile Gly Glu His 
            180                 185                 190         
Trp Gly Lys Gly Ser Pro Cys Thr Asn Val Ala Val Asn Pro Gly Asp 
        195                 200                 205             
Cys Pro Pro Leu Glu Leu Ile Asn Thr Val Ile Gln Asp Gly Asp Met 
    210                 215                 220                 
Val Asp Thr Gly Phe Gly Ala Met Asp Phe Thr Thr Leu Gln Ala Asn 
225                 230                 235                 240 
Lys Ser Glu Val Pro Leu Asp Ile Cys Thr Ser Ile Cys Lys Tyr Pro 
                245                 250                 255     
Asp Tyr Ile Lys Met Val Ser Glu Pro Tyr Gly Asp Ser Leu Phe Phe 
            260                 265                 270         
Tyr Leu Arg Arg Glu Gln Met Phe Val Arg His Leu Phe Asn Arg Ala 
        275                 280                 285             
Gly Thr Val Gly Glu Asn Val Pro Asp Asp Leu Tyr Ile Lys Gly Ser 
    290                 295                 300                 
Gly Ser Thr Ala Asn Leu Ala Ser Ser Asn Tyr Phe Pro Thr Pro Ser 
305                 310                 315                 320 
Gly Ser Met Val Thr Ser Asp Ala Gln Ile Phe Asn Lys Pro Tyr Trp 
                325                 330                 335     
Leu Gln Arg Ala Gln Gly His Asn Asn Gly Ile Cys Trp Gly Asn Gln 
            340                 345                 350         
Leu Phe Val Thr Val Val Asp Thr Thr Arg Ser Thr Asn Met Ser Leu 
        355                 360                 365             
Cys Ala Ala Ile Ser Thr Ser Glu Thr Thr Tyr Lys Asn Thr Asn Phe 
    370                 375                 380                 
Lys Glu Tyr Leu Arg His Gly Glu Glu Tyr Asp Leu Gln Phe Ile Phe 
385                 390                 395                 400 
Gln Leu Cys Lys Ile Thr Leu Thr Ala Asp Val Met Thr Tyr Ile His 
                405                 410                 415     
Ser Met Asn Ser Thr Ile Leu Glu Asp Trp Asn Phe Gly Leu Gln Pro 
            420                 425                 430         
Pro Pro Gly Gly Thr Leu Glu Asp Thr Tyr Arg Phe Val Thr Ser Gln 
        435                 440                 445             
Ala Ile Ala Cys Gln Lys His Thr Pro Pro Ala Pro Lys Glu Asp Pro 
    450                 455                 460                 
Leu Lys Lys Tyr Thr Phe Trp Glu Val Asn Leu Lys Glu Lys Phe Ser 
465                 470                 475                 480 
Ala Asp Leu Asp Gln Phe Pro Leu Gly Arg Lys Phe Leu Leu Gln Ala 
                485                 490                 495     
Gly Leu Lys Ala Lys Pro Lys Phe Thr Leu Gly Lys Arg Lys Ala Thr 
            500                 505                 510         
Pro Thr Thr Ser Ser Thr Ser Thr Thr Ala Lys Arg Lys Lys Arg Lys 
        515                 520                 525             
Leu Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val 
    530                 535                 540                 
Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser Ser Gly 
545                 550                 555                 560 
Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser Ala Gln 
                565                 570                 575     
Gly Ser Asp Val Ser Leu Thr Ala 
            580                 

<210>  3
<211>  1677
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
tctagagcca ccatgcgggt cacggcgccc cgaaccgtcc tcctgctgct ctcggcggcc        60
ctggccctga ccgagacctg ggccatgcga cacaaacgtt ctgcaaaacg cacaaaacgt       120
gcatcggcta cccaacttta taaaacatgc aaacaggcag gtacatgtcc acctgacatt       180
atacctaagg ttgaaggcaa aactattgct gatcaaatat tacaatatgg aagtatgggt       240
gtattttttg gtgggttagg aattggaaca gggtcgggta caggcggacg cactgggtat       300
attccattgg gaacaaggcc tcccacagct acagatacac ttgctcctgt aagaccccct       360
ttaacagtag atcctgtggg cccttctgat ccttctatag tttctttagt ggaagaaact       420
agttttattg atgctggtgc accaacatct gtaccttcca ttcccccaga tgtatcagga       480
tttagtatta ctacttcaac tgataccaca cctgctatat tagatattaa taatactgtt       540
actactgtta ctacacataa taatcccact ttcactgacc catctgtatt gcagcctcca       600
acacctgcag aaactggagg gcattttaca ctttcatcat ccactattag tacacataat       660
tatgaagaaa ttcctatgga tacatttatt gttagcacaa accctaacac agtaactagt       720
agcacaccca taccagggtc tcgcccagtg gcacgcctag gattatatag tcgcacaaca       780
caacaggtta aagttgtaga ccctgctttt gtaaccactc ccactaaact tattacatat       840
gataatcctg catatgaagg tatagatgtg gataatacat tatatttttc tagtaatgat       900
aatagtatta atatagctcc agatcctgac tttttggata tagttgcttt acataggcca       960
gcattaacct ctaggcgtac tggcattagg tacagtagaa ttggtaataa acaaacacta      1020
cgtactcgta gtggaaaatc tataggtgct aaggtacatt attattatga tttaagtact      1080
attgatcctg cagaagaaat agaattacaa actataacac cttctacata tactaccact      1140
tcacatgcag cctcacctac ttctattaat aatggattat atgatattta tgcagatgac      1200
tttattacag atacttctac aaccccggta ccatctgtac cctctacatc tttatcaggt      1260
tatattcctg caaatacaac aattcctttt ggtggtgcat acaatattcc tttagtatca      1320
ggtcctgata tacccattaa tataactgac caagctcctt cattaattcc tatagttcca      1380
gggtctccac aatatacaat tattgctgat gcaggtgact tttatttaca tcctagttat      1440
tacatgttac gaaaacgacg taaacgttta ccatattttt tttcagatgt ctctttggct      1500
gccatcgtgg gcattgttgc tggcctggct gtcctagcag ttgtggtcat cggagctgtg      1560
gtcgctgctg tgatgtgtag gaggaagagt tcaggtggaa aaggagggag ctactctcag      1620
gctgcgtgca gcgacagtgc ccagggctct gatgtgtctc tcacagctta agtcgac         1677

<210>  4
<211>  552
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Met Arg His Lys Arg Ser Ala Lys 
            20                  25                  30          
Arg Thr Lys Arg Ala Ser Ala Thr Gln Leu Tyr Lys Thr Cys Lys Gln 
        35                  40                  45              
Ala Gly Thr Cys Pro Pro Asp Ile Ile Pro Lys Val Glu Gly Lys Thr 
    50                  55                  60                  
Ile Ala Asp Gln Ile Leu Gln Tyr Gly Ser Met Gly Val Phe Phe Gly 
65                  70                  75                  80  
Gly Leu Gly Ile Gly Thr Gly Ser Gly Thr Gly Gly Arg Thr Gly Tyr 
                85                  90                  95      
Ile Pro Leu Gly Thr Arg Pro Pro Thr Ala Thr Asp Thr Leu Ala Pro 
            100                 105                 110         
Val Arg Pro Pro Leu Thr Val Asp Pro Val Gly Pro Ser Asp Pro Ser 
        115                 120                 125             
Ile Val Ser Leu Val Glu Glu Thr Ser Phe Ile Asp Ala Gly Ala Pro 
    130                 135                 140                 
Thr Ser Val Pro Ser Ile Pro Pro Asp Val Ser Gly Phe Ser Ile Thr 
145                 150                 155                 160 
Thr Ser Thr Asp Thr Thr Pro Ala Ile Leu Asp Ile Asn Asn Thr Val 
                165                 170                 175     
Thr Thr Val Thr Thr His Asn Asn Pro Thr Phe Thr Asp Pro Ser Val 
            180                 185                 190         
Leu Gln Pro Pro Thr Pro Ala Glu Thr Gly Gly His Phe Thr Leu Ser 
        195                 200                 205             
Ser Ser Thr Ile Ser Thr His Asn Tyr Glu Glu Ile Pro Met Asp Thr 
    210                 215                 220                 
Phe Ile Val Ser Thr Asn Pro Asn Thr Val Thr Ser Ser Thr Pro Ile 
225                 230                 235                 240 
Pro Gly Ser Arg Pro Val Ala Arg Leu Gly Leu Tyr Ser Arg Thr Thr 
                245                 250                 255     
Gln Gln Val Lys Val Val Asp Pro Ala Phe Val Thr Thr Pro Thr Lys 
            260                 265                 270         
Leu Ile Thr Tyr Asp Asn Pro Ala Tyr Glu Gly Ile Asp Val Asp Asn 
        275                 280                 285             
Thr Leu Tyr Phe Ser Ser Asn Asp Asn Ser Ile Asn Ile Ala Pro Asp 
    290                 295                 300                 
Pro Asp Phe Leu Asp Ile Val Ala Leu His Arg Pro Ala Leu Thr Ser 
305                 310                 315                 320 
Arg Arg Thr Gly Ile Arg Tyr Ser Arg Ile Gly Asn Lys Gln Thr Leu 
                325                 330                 335     
Arg Thr Arg Ser Gly Lys Ser Ile Gly Ala Lys Val His Tyr Tyr Tyr 
            340                 345                 350         
Asp Leu Ser Thr Ile Asp Pro Ala Glu Glu Ile Glu Leu Gln Thr Ile 
        355                 360                 365             
Thr Pro Ser Thr Tyr Thr Thr Thr Ser His Ala Ala Ser Pro Thr Ser 
    370                 375                 380                 
Ile Asn Asn Gly Leu Tyr Asp Ile Tyr Ala Asp Asp Phe Ile Thr Asp 
385                 390                 395                 400 
Thr Ser Thr Thr Pro Val Pro Ser Val Pro Ser Thr Ser Leu Ser Gly 
                405                 410                 415     
Tyr Ile Pro Ala Asn Thr Thr Ile Pro Phe Gly Gly Ala Tyr Asn Ile 
            420                 425                 430         
Pro Leu Val Ser Gly Pro Asp Ile Pro Ile Asn Ile Thr Asp Gln Ala 
        435                 440                 445             
Pro Ser Leu Ile Pro Ile Val Pro Gly Ser Pro Gln Tyr Thr Ile Ile 
    450                 455                 460                 
Ala Asp Ala Gly Asp Phe Tyr Leu His Pro Ser Tyr Tyr Met Leu Arg 
465                 470                 475                 480 
Lys Arg Arg Lys Arg Leu Pro Tyr Phe Phe Ser Asp Val Ser Leu Ala 
                485                 490                 495     
Ala Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val 
            500                 505                 510         
Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser Ser Gly 
        515                 520                 525             
Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser Ala Gln 
    530                 535                 540                 
Gly Ser Asp Val Ser Leu Thr Ala 
545                 550         

<210>  5
<211>  1188
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  5
tctagagcca ccatgcgggt cacggcgccc cgaaccgtcc tcctgctgct ctcggcggcc        60
ctggccctga ccgagacctg ggccatgttc caggacccac aggagcgacc cataaagata       120
ggagatttat gcacagagct gcaaacaact atacatgata taatattaga atgtgtgtac       180
tgcaagcaac agttactgcg acgtgaggta tatgactttg cttttcggga tttatgcata       240
gtatatagag atgggaatcc atatgcagtg tgtgataaat gtttaaagtt ttattctaaa       300
attagtgagt atagatatta ttgttatagt ttgtatggaa caacattaga acagcaatac       360
aacaaaccgt tgtgtgattt gttgatgcat ggagatacac ctacattgca tgaatatatg       420
ttagatttgc aaccagagac aactgatctc tactgttatg agcaattaag tgacagctca       480
gaggaggagg atgaaataga tggtccagct ggacaagcag aaccggacag agcccattac       540
aatattgtaa ccttttgtta ttctaaaatt agtgagtata gatattattg ttatagtttg       600
tatggaacaa cattagaaca gcaatacaac aaaccgttgt gtgatttgtt gattaggtgt       660
attaactgtc aaaagccact gtgtcctgaa gaaaagcaaa gacatctgga caaaaagcaa       720
agattccata atataagggg tttgtggacc ggtcgatgta tgtcttgttg cagatcatca       780
agaacacgta gagaaaccca gctgatagat ggtccagctg gacaagcaga accggacaga       840
gcccattaca atattgtaac cttttgttgc aagtgtgact ctacgcttcg gttgtgcgta       900
caaagcacac acgtagacat tcgtactttg gaagacctgt taatgggcac actaggaatt       960
gtgtgcccca tctgttccca gaaaccatac ccatacgatg ttccagatta cgctatcgtg      1020
ggcattgttg ctggcctggc tgtcctagca gttgtggtca tcggagctgt ggtcgctgct      1080
gtgatgtgta ggaggaagag ttcaggtgga aaaggaggga gctactctca ggctgcgtgc      1140
agcgacagtg cccagggctc tgatgtgtct ctcacagctt aagtcgac                   1188

<210>  6
<211>  389
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Met Phe Gln Asp Pro Gln Glu Arg 
            20                  25                  30          
Pro Ile Lys Ile Gly Asp Leu Cys Thr Glu Leu Gln Thr Thr Ile His 
        35                  40                  45              
Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg 
    50                  55                  60                  
Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp 
65                  70                  75                  80  
Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys 
                85                  90                  95      
Ile Ser Glu Tyr Arg Tyr Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu 
            100                 105                 110         
Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Met His Gly Asp 
        115                 120                 125             
Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
    130                 135                 140                 
Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser Glu Glu Glu Asp 
145                 150                 155                 160 
Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr 
                165                 170                 175     
Asn Ile Val Thr Phe Cys Tyr Ser Lys Ile Ser Glu Tyr Arg Tyr Tyr 
            180                 185                 190         
Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro 
        195                 200                 205             
Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys 
    210                 215                 220                 
Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe His Asn 
225                 230                 235                 240 
Ile Arg Gly Leu Trp Thr Gly Arg Cys Met Ser Cys Cys Arg Ser Ser 
                245                 250                 255     
Arg Thr Arg Arg Glu Thr Gln Leu Ile Asp Gly Pro Ala Gly Gln Ala 
            260                 265                 270         
Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys 
        275                 280                 285             
Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg 
    290                 295                 300                 
Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile 
305                 310                 315                 320 
Cys Ser Gln Lys Pro Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile Val 
                325                 330                 335     
Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val Ile Gly Ala 
            340                 345                 350         
Val Val Ala Ala Val Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly 
        355                 360                 365             
Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser Ala Gln Gly Ser Asp 
    370                 375                 380                 
Val Ser Leu Thr Ala 
385                 

<210>  7
<211>  4077
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
tctagagcca ccatgcgggt cacggcgccc cgaaccgtcc tcctgctgct ctcggcggcc        60
ctggccctga ccgagacctg ggccatgttt gtttttcttg ttttattgcc actagtctct       120
agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc       180
acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag       240
gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg       300
accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt       360
gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg       420
aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa       480
tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg       540
atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct       600
cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt       660
gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta       720
gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt       780
attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt       840
gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct       900
aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca       960
cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc      1020
tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt      1080
acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct      1140
tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca      1200
tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt      1260
actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca      1320
gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc      1380
gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg      1440
tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc      1500
tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta      1560
caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta      1620
ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat      1680
ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt      1740
actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact      1800
actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt      1860
ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat      1920
caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact      1980
tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg      2040
gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct      2100
agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc      2160
attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt      2220
gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc      2280
aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt      2340
ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt      2400
gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca      2460
ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca      2520
agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc      2580
ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca      2640
caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa      2700
tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct      2760
gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca      2820
cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc      2880
aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc      2940
aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca      3000
atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa      3060
attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta      3120
attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt      3180
gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc      3240
cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa      3300
aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa      3360
ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca      3420
caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt      3480
gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta      3540
gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt      3600
aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat      3660
ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg      3720
ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt      3780
atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc      3840
tgctgcaaat ttgatgaaga cgactctgag ccagtgctca aaggagtcaa attacattac      3900
acaatcgtgg gcattgttgc tggcctggct gtcctagcag ttgtggtcat cggagctgtg      3960
gtcgctgctg tgatgtgtag gaggaagagt tcaggtggaa aaggagggag ctactctcag      4020
gctgcgtgca gcgacagtgc ccagggctct gatgtgtctc tcacagctta agtcgac         4077

<210>  8
<211>  1352
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Met Phe Val Phe Leu Val Leu Leu 
            20                  25                  30          
Pro Leu Val Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu 
        35                  40                  45              
Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp 
    50                  55                  60                  
Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu 
65                  70                  75                  80  
Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly 
                85                  90                  95      
Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp 
            100                 105                 110         
Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp 
        115                 120                 125             
Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val 
    130                 135                 140                 
Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys 
145                 150                 155                 160 
Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp 
                165                 170                 175     
Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe 
            180                 185                 190         
Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly 
        195                 200                 205             
Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr 
    210                 215                 220                 
Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu 
225                 230                 235                 240 
Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly 
                245                 250                 255     
Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr 
            260                 265                 270         
Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala 
        275                 280                 285             
Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn 
    290                 295                 300                 
Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu 
305                 310                 315                 320 
Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile 
                325                 330                 335     
Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
            340                 345                 350         
Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
        355                 360                 365             
Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
    370                 375                 380                 
Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
385                 390                 395                 400 
Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
                405                 410                 415     
Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
            420                 425                 430         
Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
        435                 440                 445             
Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
    450                 455                 460                 
Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
465                 470                 475                 480 
Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
                485                 490                 495     
Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
            500                 505                 510         
Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
        515                 520                 525             
Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
    530                 535                 540                 
Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn 
545                 550                 555                 560 
Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu 
                565                 570                 575     
Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp 
            580                 585                 590         
Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile 
        595                 600                 605             
Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro 
    610                 615                 620                 
Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn 
625                 630                 635                 640 
Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr 
                645                 650                 655     
Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly 
            660                 665                 670         
Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile 
        675                 680                 685             
Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser 
    690                 695                 700                 
Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr 
705                 710                 715                 720 
Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
                725                 730                 735     
Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
            740                 745                 750         
Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
        755                 760                 765             
Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
    770                 775                 780                 
Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
785                 790                 795                 800 
Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
                805                 810                 815     
Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
            820                 825                 830         
Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn 
        835                 840                 845             
Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
    850                 855                 860                 
Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
865                 870                 875                 880 
Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
                885                 890                 895     
Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe 
            900                 905                 910         
Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr 
        915                 920                 925             
Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
    930                 935                 940                 
Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
945                 950                 955                 960 
Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
                965                 970                 975     
Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
            980                 985                 990         
Asn Phe Gly Ala Ile Ser Ser Val  Leu Asn Asp Ile Leu  Ser Arg Leu 
        995                 1000                 1005             
Asp Lys  Val Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly Arg 
    1010                 1015                 1020                 
Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  
1025                 1030                 1035                 1040 
Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys 
                1045                 1050                 1055     
Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His 
            1060                 1065                 1070         
Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
        1075                 1080                 1085             
Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala 
    1090                 1095                 1100                 
Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val Phe Val  
1105                 1110                 1115                 1120 
Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe Tyr Glu  Pro 
                1125                 1130                 1135     
Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val 
            1140                 1145                 1150         
Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
        1155                 1160                 1165             
Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr 
    1170                 1175                 1180                 
Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  
1185                 1190                 1195                 1200 
Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn 
                1205                 1210                 1215     
Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln 
            1220                 1225                 1230         
Tyr Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
        1235                 1240                 1245             
Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser Cys 
    1250                 1255                 1260                 
Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys Lys Phe  
1265                 1270                 1275                 1280 
Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys Leu His  Tyr 
                1285                 1290                 1295     
Thr Ile Val Gly  Ile Val Ala Gly Leu  Ala Val Leu Ala Val  Val Val 
            1300                 1305                 1310         
Ile Gly Ala  Val Val Ala Ala Val  Met Cys Arg Arg Lys  Ser Ser Gly 
        1315                 1320                 1325             
Gly Lys  Gly Gly Ser Tyr Ser  Gln Ala Ala Cys Ser  Asp Ser Ala Gln 
    1330                 1335                 1340                 
Gly  Ser Asp Val Ser Leu  Thr Ala 
1345                 1350         

<210>  9
<211>  2406
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
tctagagcca ccatgcgggt cacggcgccc cgaaccgtcc tcctgctgct ctcggcggcc        60
ctggccctga ccgagacctg ggccatgtct gataatggac cccaaaatca gcgaaatgca       120
ccccgcatta cgtttggtgg accctcagat tcaactggca gtaaccagaa tggagaacgc       180
agtggggcgc gatcaaaaca acgtcggccc caaggtttac ccaataatac tgcgtcttgg       240
ttcaccgctc tcactcaaca tggcaaggaa gaccttaaat tccctcgagg acaaggcgtt       300
ccaattaaca ccaatagcag tccagatgac caaattggct actaccgaag agctaccaga       360
cgaattcgtg gtggtgacgg taaaatgaaa gatctcagtc caagatggta tttctactac       420
ctaggaactg ggccagaagc tggacttccc tatggtgcta acaaagacgg catcatatgg       480
gttgcaactg agggagcctt gaatacacca aaagatcaca ttggcacccg caatcctgct       540
aacaatgctg caatcgtgct acaacttcct caaggaacaa cattgccaaa aggcttctac       600
gcagaaggga gcagaggcgg cagtcaagcc tcttctcgtt cctcatcacg tagtcgcaac       660
agttcaagaa attcaactcc aggcagcagt aggggaactt ctcctgctag aatggctggc       720
aatggcggtg atgctgctct tgctttgctg ctgcttgaca gattgaacca gcttgagagc       780
aaaatgtctg gtaaaggcca acaacaacaa ggccaaactg tcactaagaa atctgctgct       840
gaggcttcta agaagcctcg gcaaaaacgt actgccacta aagcatacaa tgtaacacaa       900
gctttcggca gacgtggtcc agaacaaacc caaggaaatt ttggggacca ggaactaatc       960
agacaaggaa ctgattacaa acattggccg caaattgcac aatttgcccc cagcgcttca      1020
gcgttcttcg gaatgtcgcg cattggcatg gaagtcacac cttcgggaac gtggttgacc      1080
tacacaggtg ccatcaaatt ggatgacaaa gatccaaatt tcaaagatca agtcattttg      1140
ctgaataagc atattgacgc atacaaaaca ttcccaccaa cagagcctaa aaaggacaaa      1200
aagaagaagg ctgatgaaac tcaagcctta ccgcagagac agaagaaaca gcaaactgtg      1260
actcttcttc ctgctgcaga tttggatgat ttctccaaac aattgcaaca atccatgagc      1320
agtgctgact caactcaggc catggcagat tccaacggta ctattaccgt tgaagagctt      1380
aaaaagctcc ttgaacaatg gaacctagta ataggtttcc tattccttac atggatttgt      1440
cttctacaat ttgcctatgc caacaggaat aggtttttgt atataattaa gttaattttc      1500
ctctggctgt tatggccagt aactttagct tgttttgtgc ttgctgctgt ttacagaata      1560
aattggatca ccggtggaat tgctatcgca atggcttgtc ttgtaggctt gatgtggctc      1620
agctacttca ttgcttcttt cagactgttt gcgcgtacgc gttccatgtg gtcattcaat      1680
ccagaaacta acattcttct caacgtgcca ctccatggca ctattctgac cagaccgcta      1740
ctagaaagtg aactcgtaat cggagctgtg atccttcgtg gacatcttcg tattgctgga      1800
caccatctag gacgctgtga catcaaggac ctgcctaaag aaatcactgt tgctacatca      1860
cgaacgcttt cttattacaa attgggagct tcgcagcgtg tagcaggtga ctcaggtttt      1920
gctgcataca gtcgctacag gattggcaac tataaattaa acacagacca ttccagtagc      1980
agtgacaata ttgctttgct tgtacagatg tactcattcg tttcggaaga gacaggtacg      2040
ttaatagtta atagcgtact tctttttctt gctttcgtgg tattcttgct agttacacta      2100
gccatcctta ctgcgcttcg attgtgtgcg tactgctgca atattgttaa cgtgagtctt      2160
gtaaaacctt ctttttacgt ttactctcgt gttaaaaatc tgaattcttc aagagttcct      2220
gatcttctgg tcatcgtggg cattgttgct ggcctggctg tcctagcagt tgtggtcatc      2280
ggagctgtgg tcgctgctgt gatgtgtagg aggaagagtt caggtggaaa aggagggagc      2340
tactctcagg ctgcgtgcag cgacagtgcc cagggctctg atgtgtctct cacagcttaa      2400
gtcgac                                                                 2406

<210>  12
<211>  795
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Met Ser Asp Asn Gly Pro Gln Asn 
            20                  25                  30          
Gln Arg Asn Ala Pro Arg Ile Thr Phe Gly Gly Pro Ser Asp Ser Thr 
        35                  40                  45              
Gly Ser Asn Gln Asn Gly Glu Arg Ser Gly Ala Arg Ser Lys Gln Arg 
    50                  55                  60                  
Arg Pro Gln Gly Leu Pro Asn Asn Thr Ala Ser Trp Phe Thr Ala Leu 
65                  70                  75                  80  
Thr Gln His Gly Lys Glu Asp Leu Lys Phe Pro Arg Gly Gln Gly Val 
                85                  90                  95      
Pro Ile Asn Thr Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr Tyr Arg 
            100                 105                 110         
Arg Ala Thr Arg Arg Ile Arg Gly Gly Asp Gly Lys Met Lys Asp Leu 
        115                 120                 125             
Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro Glu Ala Gly 
    130                 135                 140                 
Leu Pro Tyr Gly Ala Asn Lys Asp Gly Ile Ile Trp Val Ala Thr Glu 
145                 150                 155                 160 
Gly Ala Leu Asn Thr Pro Lys Asp His Ile Gly Thr Arg Asn Pro Ala 
                165                 170                 175     
Asn Asn Ala Ala Ile Val Leu Gln Leu Pro Gln Gly Thr Thr Leu Pro 
            180                 185                 190         
Lys Gly Phe Tyr Ala Glu Gly Ser Arg Gly Gly Ser Gln Ala Ser Ser 
        195                 200                 205             
Arg Ser Ser Ser Arg Ser Arg Asn Ser Ser Arg Asn Ser Thr Pro Gly 
    210                 215                 220                 
Ser Ser Arg Gly Thr Ser Pro Ala Arg Met Ala Gly Asn Gly Gly Asp 
225                 230                 235                 240 
Ala Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu Ser 
                245                 250                 255     
Lys Met Ser Gly Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr Lys 
            260                 265                 270         
Lys Ser Ala Ala Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr Ala 
        275                 280                 285             
Thr Lys Ala Tyr Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu 
    290                 295                 300                 
Gln Thr Gln Gly Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr 
305                 310                 315                 320 
Asp Tyr Lys His Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser 
                325                 330                 335     
Ala Phe Phe Gly Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly 
            340                 345                 350         
Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro 
        355                 360                 365             
Asn Phe Lys Asp Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr 
    370                 375                 380                 
Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala 
385                 390                 395                 400 
Asp Glu Thr Gln Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val 
                405                 410                 415     
Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln 
            420                 425                 430         
Gln Ser Met Ser Ser Ala Asp Ser Thr Gln Ala Met Ala Asp Ser Asn 
        435                 440                 445             
Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu Leu Glu Gln Trp Asn 
    450                 455                 460                 
Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile Cys Leu Leu Gln Phe 
465                 470                 475                 480 
Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile Ile Lys Leu Ile Phe 
                485                 490                 495     
Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys Phe Val Leu Ala Ala 
            500                 505                 510         
Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile Ala Ile Ala Met Ala 
        515                 520                 525             
Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe Ile Ala Ser Phe Arg 
    530                 535                 540                 
Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu Thr Asn 
545                 550                 555                 560 
Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile Leu Thr Arg Pro Leu 
                565                 570                 575     
Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly His Leu 
            580                 585                 590         
Arg Ile Ala Gly His His Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro 
        595                 600                 605             
Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Leu 
    610                 615                 620                 
Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly Phe Ala Ala Tyr Ser 
625                 630                 635                 640 
Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His Ser Ser Ser 
                645                 650                 655     
Ser Asp Asn Ile Ala Leu Leu Val Gln Met Tyr Ser Phe Val Ser Glu 
            660                 665                 670         
Glu Thr Gly Thr Leu Ile Val Asn Ser Val Leu Leu Phe Leu Ala Phe 
        675                 680                 685             
Val Val Phe Leu Leu Val Thr Leu Ala Ile Leu Thr Ala Leu Arg Leu 
    690                 695                 700                 
Cys Ala Tyr Cys Cys Asn Ile Val Asn Val Ser Leu Val Lys Pro Ser 
705                 710                 715                 720 
Phe Tyr Val Tyr Ser Arg Val Lys Asn Leu Asn Ser Ser Arg Val Pro 
                725                 730                 735     
Asp Leu Leu Val Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala 
            740                 745                 750         
Val Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys 
        755                 760                 765             
Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp 
    770                 775                 780                 
Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
785                 790                 795 

<210>  11
<211>  804
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  11
tctagagcca ccatgcgggt cacggcgccc cgaaccgtcc tcctgctgct ctcggcggcc        60
ctggccctga ccgagacctg ggccatggcc ttaccagtga ccgccttgct cctgccgctg       120
gccttgctgc tccacgccgc caggccgagc cagttccggg tgtcgccgct ggatcggacc       180
tggaacctgg gcgagacagt ggagctgaag tgccaggtgc tgctgtccaa cccgacgtcg       240
ggctgctcgt ggctcttcca gccgcgcggc gccgccgcca gtcccacctt cctcctatac       300
ctctcccaaa acaagcccaa ggcggccgag gggctggaca cccagcggtt ctcgggcaag       360
aggttggggg acaccttcgt cctcaccctg agcgacttcc gccgagagaa cgagggctac       420
tatttctgct cggccctgag caactccatc atgtacttca gccacttcgt gccggtcttc       480
ctgccagcga agcccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc       540
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg       600
cacacgaggg ggctggactt cgcctgtgat atcgtgggca ttgttgctgg cctggctgtc       660
ctagcagttg tggtcatcgg agctgtggtc gctgctgtga tgtgtaggag gaagagttca       720
ggtggaaaag gagggagcta ctctcaggct gcgtgcagcg acagtgccca gggctctgat       780
gtgtctctca cagcttaagt cgac                                              804

<210>  12
<211>  261
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Met Ala Leu Pro Val Thr Ala Leu 
            20                  25                  30          
Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Ser Gln Phe 
        35                  40                  45              
Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu Thr Val Glu 
    50                  55                  60                  
Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly Cys Ser Trp 
65                  70                  75                  80  
Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe Leu Leu Tyr 
                85                  90                  95      
Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp Thr Gln Arg 
            100                 105                 110         
Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr Leu Ser Asp 
        115                 120                 125             
Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala Leu Ser Asn 
    130                 135                 140                 
Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys 
145                 150                 155                 160 
Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                165                 170                 175     
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            180                 185                 190         
Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Val 
        195                 200                 205             
Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val Ile Gly Ala 
    210                 215                 220                 
Val Val Ala Ala Val Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly 
225                 230                 235                 240 
Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser Ala Gln Gly Ser Asp 
                245                 250                 255     
Val Ser Leu Thr Ala 
            260     

