                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
       Biocytogen JiangSu Co.,Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL1B
        AND/OR IL1A

<130>  1

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  1348
<212>  DNA
<213>  Mus musculus

<400>  1
aacaaaccct gcagtggttc gaggcctaat aggctcatct gggatcctct ccagccaagc       60

ttccttgtgc aagtgtctga agcagctatg gcaactgttc ctgaactcaa ctgtgaaatg      120

ccaccttttg acagtgatga gaatgacctg ttctttgaag ttgacggacc ccaaaagatg      180

aagggctgct tccaaacctt tgacctgggc tgtcctgatg agagcatcca gcttcaaatc      240

tcgcagcagc acatcaacaa gagcttcagg caggcagtat cactcattgt ggctgtggag      300

aagctgtggc agctacctgt gtctttcccg tggaccttcc aggatgagga catgagcacc      360

ttcttttcct tcatctttga agaagagccc atcctctgtg actcatggga tgatgatgat      420

aacctgctgg tgtgtgacgt tcccattaga caactgcact acaggctccg agatgaacaa      480

caaaaaagcc tcgtgctgtc ggacccatat gagctgaaag ctctccacct caatggacag      540

aatatcaacc aacaagtgat attctccatg agctttgtac aaggagaacc aagcaacgac      600

aaaatacctg tggccttggg cctcaaagga aagaatctat acctgtcctg tgtaatgaaa      660

gacggcacac ccaccctgca gctggagagt gtggatccca agcaataccc aaagaagaag      720

atggaaaaac ggtttgtctt caacaagata gaagtcaaga gcaaagtgga gtttgagtct      780

gcagagttcc ccaactggta catcagcacc tcacaagcag agcacaagcc tgtcttcctg      840

ggaaacaaca gtggtcagga cataattgac ttcaccatgg aatccgtgtc ttcctaaagt      900

atgggctgga ctgtttctaa tgccttcccc agggcatgtt aaggagctcc cttttcgtga      960

atgagcagac agctcaatct ccaggggact ccttagtcct cggccaagac aggtcgctca     1020

gggtcacaag aaaccatggc acattctgtt caaagagagc ctgtgttttc ctccttgcct     1080

ctgatgggca accacttacc tatttattta tgtatttatt gattggttga tctatttaag     1140

ttgattcaag gggacattag gcagcactct ctagaacaga acctagctgt caacgtgtgg     1200

gggatgaatt ggtcatagcc cgcactgagg tctttcattg aagctgagaa taaataggtt     1260

cctataatat ggatgagact ttttatgaat gaagcaccag cacattgctt tgatgagtat     1320

gaaataaatt tcattaaaac aaacaaac                                        1348


<210>  2
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Thr Val Pro Glu Leu Asn Cys Glu Met Pro Pro Phe Asp Ser 
1               5                   10                  15      


Asp Glu Asn Asp Leu Phe Phe Glu Val Asp Gly Pro Gln Lys Met Lys 
            20                  25                  30          


Gly Cys Phe Gln Thr Phe Asp Leu Gly Cys Pro Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Gln Ile Ser Gln Gln His Ile Asn Lys Ser Phe Arg Gln Ala Val 
    50                  55                  60                  


Ser Leu Ile Val Ala Val Glu Lys Leu Trp Gln Leu Pro Val Ser Phe 
65                  70                  75                  80  


Pro Trp Thr Phe Gln Asp Glu Asp Met Ser Thr Phe Phe Ser Phe Ile 
                85                  90                  95      


Phe Glu Glu Glu Pro Ile Leu Cys Asp Ser Trp Asp Asp Asp Asp Asn 
            100                 105                 110         


Leu Leu Val Cys Asp Val Pro Ile Arg Gln Leu His Tyr Arg Leu Arg 
        115                 120                 125             


Asp Glu Gln Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys 
    130                 135                 140                 


Ala Leu His Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser 
145                 150                 155                 160 


Met Ser Phe Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala 
                165                 170                 175     


Leu Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp 
            180                 185                 190         


Gly Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro 
        195                 200                 205             


Lys Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys 
    210                 215                 220                 


Ser Lys Val Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser 
225                 230                 235                 240 


Thr Ser Gln Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly 
                245                 250                 255     


Gln Asp Ile Ile Asp Phe Thr Met Glu Ser Val Ser Ser 
            260                 265                 


<210>  3
<211>  1507
<212>  DNA
<213>  Homo sapiens

<400>  3
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaagaa     1500

aaaaaaa                                                               1507


<210>  4
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  5
<211>  5869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 112830361-112836229 of NCBI accession 
       number NC_000002.12

<400>  5
atggcagaag tacctgagct cgccagtgaa atgatggctt attacaggtc agtggagacg       60

ctgagaccag taacatgagc aggtctcctc tttcaagagt agagtgttat ctgtgcttgg      120

agaccagatt tttcccctaa attgcctctt tcagtggcaa acagggtgcc aagtaaatct      180

gatttaaaga ctactttccc attacaagtc cctccagcct tgggacctgg aggctatcca      240

gatgtgttgt tgcaagggct tcctgcagag gcaaatgggg agaaaagact ccaagcccac      300

aatacaagga atccctttgc aaagtgtggc ttggagggag agggagagct cagattttag      360

ctgactctgc tgggctagag gttaggcctc aagatccaac agggagcacc cagggtgccc      420

acctgccagg cctagaatct gccttctgga ctgttctgcg catatcactg tgaaacttgc      480

caggtgtttc aggcagcttt gagaggcagg ctgtttgcag tttcttatga acagtcaagt      540

cttgtacaca gggaaggaaa aataaacctg tttagaagac ataattgaga catgtccctg      600

tttttattac agtggcaatg aggatgactt gttctttgaa gctgatggcc ctaaacagat      660

gaaggtaaga ctatgggttt aactcccaac ccaaggaagg gctctaacac agggaaagct      720

caaagaaggg agttctgggc cactttgatg ccatggtatt ttgttttaga aagactttaa      780

cctcttccag tgagacacag gctgcaccac ttgctgacct ggccacttgg tcatcatatc      840

accacagtca ctcactaacg ttggtggtgg tggccacact tggtggtgac aggggaggag      900

tagtgataat gtttcccatt tcatagtagg aagacaacca agtcttcaac ataaatttga      960

ttatcctttt aagagatgga ttcagcctat gccaatcact tgagttaaac tctgaaacca     1020

agagatgatc ttgagaacta acatatgtct accccttttg agtagaatag ttttttgcta     1080

cctggggtga agcttataac aacaagacat agatgatata aacaaaaaga tgaattgaga     1140

cttgaaagaa aaccattcac ttgctgtttg accttgacaa gtcattttac ccgctttgga     1200

cctcatctga aaaataaagg gctgagctgg atgatctctg agattccagc atcctgcaac     1260

ctccagttct gaaatatttt cagttgtagc taagggcatt tgggcagcaa atggtcattt     1320

ttcagactca tccttacaaa gagccatgtt atattcctgc tgtcccttct gttttatatg     1380

atgctcagta gccttcctag gtggcccagc catcagccta gctaggtcag ttgtgcaggt     1440

tgggaggcag ccacttttct ctggctttat tttattccag tttgtgatag cctcccctag     1500

cctcataatc cagtcctcaa tcttgttaaa aacatatttc tttagaagtt ttaagactgg     1560

cataacttgt tggctgcagc tgtgggagga gcccattggc ttgtctgcct ggcctttgcc     1620

cccattgcct cttccagcag cttggctctg ctccaggcag gaaattctct cctgctcaac     1680

tttcttttgt gcacttacag gtctctttaa ctgtctttca agcctttgaa ccattatcat     1740

gccttaaggc aacctcagtg aagccttaat acggagcttc tctgaataag aggaaagtgg     1800

taacatttca caaaaagtac tctcacagga tttgcagaat gcctatgaga cagtgttatg     1860

aaaaaggaaa aaaaagaaca gtgtagaaaa attgaatact tgctgagtga gcataggtga     1920

atggaaaatg ttatggtcat ctgcatgaaa aagcaaatca tagtgtgaca gcattaggga     1980

tacaaaaaga tatagagaag gtatacatgt atggtgtagg tggggcatgt acaaaaaaga     2040

tgaacaaagt agaaatggga tttattctaa aagaatagcc tgtaaggtgt cagaaagccc     2100

acattctagt cttgagtctg cctctaacct gctgtgtgcc cttgagtaca cacttaacct     2160

ccttgagctt cagagaggga taatcttttt attttatttt attttatttt gttttgtttt     2220

gttttgtttt gttttatgag acagagtctc actctgttgc ccaggctgga gtgcagtggt     2280

acaatcttgg cttactgcat cctccacctc ctgagttcaa gcgattctcc ttcctcagtc     2340

tcctgaatag ctaggattac aggtgcaccc caccacaccc agctaatttt tgtattttta     2400

gtagagaagg ggtttcgcca tgttggccag gctggttttg aagtcctgac ctaaatgatt     2460

catccacctc ggcttcccaa agtgctggga ttacaggcat gagccaccac gcctggccca     2520

gagagggatg atctttagaa gctcgggatt ctttcaagcc ctttcctcct ctctgagctt     2580

tctactctct gatgtcaaag catggttcct ggcaggacca cctcaccagg ctccctccct     2640

cgctctctcc gcagtgctcc ttccaggacc tggacctctg ccctctggat ggcggcatcc     2700

agctacgaat ctccgaccac cactacagca agggcttcag gcaggccgcg tcagttgttg     2760

tggccatgga caagctgagg aagatgctgg ttccctgccc acagaccttc caggagaatg     2820

acctgagcac cttctttccc ttcatctttg aagaaggtag ttagccaaga gcaggcagta     2880

gatctccact tgtgtcctct tggaagtcat caagccccag ccaactcaat tcccccagag     2940

ccaaagccct ttaaaggtag aaggcccagc ggggagacaa aacaaagaag gctggaaacc     3000

aaagcaatca tctctttagt ggaaactatt cttaaagaag atcttgatgg ctactgacat     3060

ttgcaactcc ctcactcttt ctcaggggcc tttcacttac attgtcacca gaggttcgta     3120

acctccctgt gggctagtgt tatgaccatc accattttac ctaagtagct ctgttgctcg     3180

gccacagtga gcagtaatag acctgaagct ggaacccatg tctaatagtg tcaggtccag     3240

tgttcttagc caccccactc ccagcttcat ccctactggt gttgtcatca gactttgacc     3300

gtatatgctc aggtgtcctc caagaaatca aattttgccg cctcgcctca cgaggcctgc     3360

ccttctgatt ttatacctaa acaacatgtg ctccacattt cagaacctat cttcttcgac     3420

acatgggata acgaggctta tgtgcacgat gcacctgtac gatcactgaa ctgcacgctc     3480

cgggactcac agcaaaaaag cttggtgatg tctggtccat atgaactgaa agctctccac     3540

ctccagggac aggatatgga gcaacaaggt aaatggaaac atcctggttt ccctgcctgg     3600

cctcctggca gcttgctaat tctccatgtt ttaaacaaag tagaaagtta atttaaggca     3660

aatgatcaac acaagtgaaa aaaaatatta aaaaggaata tacaaacttt ggtcctagaa     3720

atggcacatt tgattgcact ggccagtgca tttgttaaca ggagtgtgac cctgagaaat     3780

tagacggctc aagcactccc aggaccatgt ccacccaagt ctcttgggca tagtgcaatg     3840

tcaattcttc cacaatatgg ggtcatttga tggacatggc ctaactgcct gtgggttctc     3900

tcttcctgtt gttgaggctg aaacaagagt gctggagcga taatgtgtcc atccccctcc     3960

ccagtcttcc ccccttgccc caacatccgt cccacccaat gccaggtggt tccttgtagg     4020

gaaattttac cgcccagcag gaacttatat ctctccgctg taacgggcaa aagtttcaag     4080

tgcggtgaac ccatcattag ctgtggtgat ctgcctggca tcgtgccaca gtagccaaag     4140

cctctgcaca ggagtgtggg caactaaggc tgctgacttt gaaggacagc ctcactcagg     4200

gggaagctat ttgctctcag ccaggccaag aaaatcctgt ttctttggaa tcgggtagta     4260

agagtgatcc cagggcctcc aattgacact gctgtgactg aggaagatca aaatgagtgt     4320

ctctctttgg agccactttc ccagctcagc ctctcctctc ccagtttctt cccatgggct     4380

actctctgtt cctgaaacag ttctggtgcc tgatttctgg cagaagtaca gcttcacctc     4440

tttcctttcc ttccacattg atcaagttgt tccgctcctg tggatgggca cattgccagc     4500

cagtgacaca atggcttcct tccttccttc cttcagcatt taaaatgtag accctctttc     4560

attctccgtt cctactgcta tgaggctctg agaaaccctc aggcctttga ggggaaaccc     4620

taaatcaaca aaatgaccct gctattgtct gtgagaagtc aagttatcct gtgtcttagg     4680

ccaaggaacc tcactgtggg ttcccacaga ggctaccaaa ttacatgtat cctactcatg     4740

gggcctaggg gttggggtga ccctgcactg ctgtgtccct aaccacaaga cccccttctt     4800

tcttcagtgg tgttctccat gtcctttgta caaggagaag aaagtaatga caaaatacct     4860

gtggccttgg gcctcaagga aaagaatctg tacctgtcct gcgtgttgaa agatgataag     4920

cccactctac agctggaggt aagtgaatgc tatggaatga agcccttctc agcctcctgc     4980

taccacttat tcccagacaa ccaccttctc cccgccccca tccctaggaa aagctgggaa     5040

caggtctatt tgacaatttt gcattaatgt aaataaattt aacataattt ttaactgcgt     5100

gcaaccttca atcctgctgc agaaaattaa atcattttgc cgatgttatt atgtcctacc     5160

atagttacaa ccccaacaga ttatatattg ttagggctgc tctcatttga tagacacctt     5220

gggaaataga tgacttaaag ggtcccatta tcatgtccac tccactccca aaattaccac     5280

cactatcacc tccagctttc tcagcaaaag cttcatttcc aagttgatgt cattctagga     5340

ccataaggaa aaatacaata aaaagcccct ggaaactagg tacttcaaga agctctagct     5400

taattttcac ccccccaaaa aaaaaaaatt ctcacctaca ttatgctcct cagcatttgg     5460

cactaagttt tagaaaagaa gaagggctct tttaataatc acacggaaag ttgggggccc     5520

agttacaact caggagtctg gctcctgatc atgtgacctg ctcgtcagtt tcctttctgg     5580

ccaacccaaa gaacatcttt cccatagcat ctttgtccct tgccccacaa aaattcttct     5640

ttctctttcg ctgcagagtg tagatcccaa aaattaccca aagaagaaga tggaaaagcg     5700

atttgtcttc aacaagatag aaatcaataa caagctggaa tttgagtctg cccagttccc     5760

caactggtac atcagcacct ctcaagcaga aaacatgccc gtcttcctgg gagggaccaa     5820

aggcggccag gatataactg acttcaccat gcaatttgtg tcttcctaa                 5869


<210>  6
<211>  4941
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  6
gtgcatgttc caacgtcaaa gatgcactca agatcttctg ggatcctcta aggggcttga       60

gttacttctg cagctcagcc ctttgtagca caaacagctt gtcttttagg atttggctgg      120

ctccactcca ctgctgctgc tgttcttgat ggtcatccca tggtacttgc atctccaaaa      180

tgctggggtc ttctgctgca actgggctgg acttatacca gtactctcct gggctctctt      240

catggtgaca agcctcaact tctctgtatg accctttcaa tcctgggcct tcagctgcca      300

ctgaggctgt attgtcagtg ccaagactca gctgctcttc catgaaccag tgtcacctgg      360

gtggctcttc cacaggacca aatttggctg ccagtggaga aatacaactt tggccatctc      420

tggaaaacag cttctgtgtg ctctcagaaa acacttccca gaagatttca cctcaataat      480

gctggacttt tcttagtcac tgctaatttc tcagctccag ctcaccagca ctgagtatct      540

aagcaaagca aaggtttcat ttttagtggt tctggaatct tgtttatcga tgcctattct      600

tcagccccag ctaatgagat attatgttat cacggaatct taattcaata taacaaatgg      660

ccctgaagaa gtctttaagc ttccttctga agcttcacaa gtcaggcctc catctttgtg      720

ttgccctcaa cgtccctatc ttccaagttc ctaggaacag ctcaccaaga attgaccact      780

ctatgggttt tcttgtacaa agtccttcca aaacaatatg ctcaggtctg tcacagtcat      840

gtcacagtaa atcttggtgc caattcattt tcatttaggt tactattact ataatgaaac      900

tccatgatca aagcaacttg gggaggaaag gatgtattct gcttacattt ccacatcaca      960

gtttatcatc aaaggaagtc aggacaggaa ctcaagcaag gcaggaacct ggaaccagga     1020

gctgatgcag cgatcatgga gggatgctgc tcactggctt gctcctcatg gcttgtcaac     1080

ctactttctt atagaaccca ggaccaccag cccagggatg gcaccaccca caacaggctg     1140

atttctcccc aagtaaatac caattaataa aatttcctac aggcttgcct acagacagat     1200

cttttggatg tattttgtca gttaaggctc ccttctctct gatgattcta gcttgtgtct     1260

agttgacata aaactaacca ggacagaaaa gatgagaggg aaagaacaga cccctaaggc     1320

ctgtgctaag tcgtcaactt aaggaataag acaaggtctg gagaaagtaa tgaggacagt     1380

cattgcttag ctctgttctg agcaagagga taagtaaaga agatgtagaa cacatacatc     1440

aactgggcct gggagctcgt gcctgtaatc tcagtccttg ggagacaaat gcaggagaat     1500

tgtcatgtac ttgaagccag tctgggctgc acagtagtca tggttatcac agcaatagaa     1560

agtaagtaaa acaggtagca aggcactttc agctttgaag aaatgcctgc ctccatcttg     1620

gaggaatgag atgtcagaac agagggaacc ttacagctta aaagtgctga gtgagtcaag     1680

agctgaaaag ttccccaaaa gctagagtgc ccgtcaccat cctggctttg ccgacttcct     1740

cttttgcttt gttcatttcc tttgccaaca tcatcatcag tatcgtcatc actatgccac     1800

acccccagca taacaatttc tatagtgagt tatttcttct actcattggg gaccaaaaag     1860

gaagtgtggt ctgagagaca gggtttgata tacatgttgt gcaacttgcc tgctctataa     1920

cgacaagggg aggaaatttg gagcccaagt cacagggcca ggatgaggtt tgatagaaca     1980

atagagtacc agaggcattg cccagtagtt ccaaaatctc cctctagaag caaaagaatc     2040

atcaaccaga tcattgcctc ctcccagaca aacctcctcc catctcttca tctcttactc     2100

acgattaaat ggccattcgt cttcatgcat gtgccttcct ccaaatcctc ccagacaacc     2160

actcctctca ggcatcagct caagggttta ggagtgttat aactagcaga tggtgaagaa     2220

gattctgtaa ctagactgag ctcaaggctc ctgaaaaatc atccagggag aagggacttg     2280

gagctgacac tcaggcccct agttaccctt ctctgtcccc tggttttcac catccctggt     2340

tcaactcaca tcagcagacc aaaggagtct ccaataatct ctgtcaggac agcccataaa     2400

atcatcagac cttccagccc tgcacacagg ctctgaggaa ggtgttagtc cctccaggca     2460

tagtttgaaa tgtggaccct gtgaaggcag aacagaaaaa tgaaccagat ggcccagaca     2520

ggacctctgg attgtctgca gaactagata atacatctta taagacctta gtgctgagaa     2580

ctgaccattg ctcaccaaac tcaaaagcaa ctgagaccct gaaccatctt cagatttcaa     2640

atcaaacata tagctggtca aaggcaggat tcttctgttt gccttcctga aatcgagatg     2700

ctgtgaacca aattaggcaa aagaaggctg cctagtaagt aaaccttgtt tcatagtaga     2760

gccttgtcta ttcctccttc caattctgtc tgtctatttc ccttcagtgc tgcagaataa     2820

gctcagtaac caaaacatac taggtacaaa ctcatctgaa tgaacacatt gccaaattcc     2880

tactcacccg ggctagctcc tactgcctgc atccatctgc caggcactgt ggagacctgg     2940

ctctaatgga gtccacagac tctctgaggg ctcagcaaag gagttaggtt tccactgagg     3000

attctactat actgtagatg tgcccaagag actgtatgca gcattcatat ggcctggttg     3060

ctcattccat ccaagcaaga agagctcccc tgggtaggct ccctgggctc tctgagttag     3120

cagtctagtg atgcttgata tggccaagag acttggtctc cccagatctt atagaaacaa     3180

gaattttcca aaacaatttt ttaggcaaag actatctctt cactttttaa gatggactgt     3240

gctcatgaac aggcagatgc ctcgttcacc acctttgcac tgtgcaactt aattcaggct     3300

cattctgctg atcacctagc actgatatgg tttcaacatg agactggcta tggtattata     3360

agtaccctgg cagggcagga aagcaggagt gggtgggtga gtgggggagc atcctcatag     3420

aggcagggga gggggagagg atagggggtt tccggagggg agacctggaa aagggataac     3480

atttgaaatg taaataaaga aaatatccaa taaaagaaaa aaataagcac cctggcatta     3540

tcagactgca taggcttgct tccagagttc cctgacccta tgataagtct acactgatac     3600

ctgcatactg tgtgtgccct gacccacaca aggaagtgcg tgtctctcca gaagcccctg     3660

ctaacacagt tgatggagag cacagaagca ccatccagtt accaaactcc aactgcaaag     3720

ctccctcagc ttaagcacaa ggaggcgaga gaggtgacac acttctgggt gtgcatctac     3780

gtgcctacct ttgttccgca catcctgact taaaatgtac agctaaccca ggaaaaccca     3840

atatttttaa tattgacacc atctgcacaa ttgtccaggg ggaaataatg cccatttcca     3900

ccacgatgac acacttgcga atgtgtcact atctgccacc ccttgacttc cagggattag     3960

aaattatttc agggtagcaa tagcctcttc ccctaagaat tcccatcaag cttctccccc     4020

ctcccccacc cttcagtttt gttgtgaaat cagttaaccc aagggaaaat ttcacagctc     4080

ttcacttctg ctttttagga ctataaaaca agggagggaa aacaagttgg acaacaaacc     4140

ctgcagtggt tcgaggccta ataggctcat ctgggatcct ctccagccaa gcttccttgt     4200

gcaagtaagt ctctctctct ctctgtctct ctctctctct gtctctctct atctctctct     4260

ctctgtctct ctctctctgt ctctgtctgt ctctctctct gtctctgtct gtctatctct     4320

ctctctctct gtctgtctct gtctctctct gtctgtctct ctctgtctct ctgtctctct     4380

ctctgtctct ctctgtctct ctctctctct ctctttcccc cccccccact gatggacttt     4440

gggcttttta tttataaaaa gtagctgtac ctccatggtt tgtgaagtac tctggaaatg     4500

agtactgtct gtatagccgc tgacatctaa aaggcagctc ctgtcttgta ggaaagcttc     4560

tttattaggg tttggctctg ctgttgcttc cttccagagc atcttcctaa tgctgttccc     4620

catgttgtag tgacccccca cacaccctaa aattattttc attgctactt cataactata     4680

attttgctac tgttatgaag tgtaaatatc tgtgttatcc aatggtctta ggtgacccct     4740

gtgaaagggc cacttgactc caaaagggcc actgttctag acctatacaa cggctcctcc     4800

gttccttcat tcctcagaga ccagtttagc atgcctgccc tgaactagag ctaagagaaa     4860

cacatatgaa ggacgcccct cggggagcta acgctggatg cccacccact ttctttcttc     4920

acacaggtgt ctgaagcagc t                                               4941


<210>  7
<211>  3458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  7
tatccacatc tagcaaggaa ccctgtctca aaaattaagg tggaaaataa ttgaggaaga       60

caactgattt tgatctctgg tctccacccc tacacacatg tgaatgcaca cacacacaca      120

cacacagagc acatatatac acaaagggat tttcattaca tatgattcat caaagaaata      180

agatcagctg aaactttaaa gggagtaagg tttgatccta aatcatttag ttcacagaca      240

cctgttcaac aaacgctgag tgcctagtac agagatgagt actctgagag ttaagaataa      300

gcttaggaga tagagggata gaaaaataga tggatggatg gatagataga tagatagata      360

gatagataga tagacagaca gacagataga tatagaaatt aaggcaacat gaccaaatag      420

agacaagatg aagtataaaa agagtagcca ggaaagacct acagggtctg gtaggagaga      480

tgacaaacca gggaggttga catttgagcc agatctaaag gaacaagagc aagttcgaaa      540

aatggagggg aaaaaggtac atcaggtcta aggtcccaaa ggaacaaagt catggggata      600

tgagagtgaa tgatgcataa ataaaatcaa gaataaccag aagctaagtc aagacacaaa      660

acaaattaca gaaaaagaaa attgtacttt atcccatata aagggagaat tctctgagct      720

tacaaagagc tccttcaata cattagtgga agaacataat gaatgcccaa caaaacaata      780

aacttaaagg gttattaaca gagcaagctg gtcacagaaa ggggaatgcc atcagatcct      840

gggcagacaa gggttactca acgttactca taagaaagtc aactcaaaag gactttgaga      900

tattgatgtg ttcctatgtg acagacaaaa atatcatagg tttaacacac cctgttaaag      960

ttggcaaaac tgtagggaaa ccccattgtt aaacatttta catggaagta tgacctctac     1020

ggaagaaaat gtgatgatgg ctttgtccca gcaattttac ttctaaggct gtacactgtg     1080

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg taacctatag     1140

gaaagataga gaaccagaat catttatttc acatggatca cttgcaaaca ttagaactaa     1200

tgcaggacca gcaaaagact ggttaaagac tcaaagatga aactgaagaa tgagaaaaga     1260

cctggctctt tgcatcaata tggaactctc tccaaaacat tcagaaaaag caagtgcgcc     1320

acccagagaa gcacactttg tgaggactaa tggaaaagag cctgagctgt tggagtccat     1380

tccaaaggaa ttcatggcct aatgtacaca aagaaataaa gtacccagac tgcaaaagaa     1440

agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa     1500

agaaagaaaa aagaaagaga gagagagaga gagagagaga gagaaagaaa gagagagagg     1560

gagagagagg gagagagagg gagagagaga gagggagaga gagagagagg gagagagaga     1620

gaggaagaaa ggagagtgga aatacaaact tacataacag agggcagaga aaagggcaaa     1680

accacctagt gtgctcatat ttgatctgaa atttctagag gatacataag gaagagccaa     1740

gaaataaaac atataagcac acataggaat aaagccttcc ccctccccca ccgccgtata     1800

ctttctatat agtttaattt ttttgtgtga atgtatcacc ttctcagata taaaatagca     1860

atgacgaaag ctttctttcc aaaacaaaag aacctaaatg accaatcaca aaaaagcaaa     1920

ggccgaacag tcagtgctgc tgagccccct tccaacacct gctttctctc cctccagctc     1980

cctaagctaa ggcagagtgg ggagggcagc tctcacctct cctggttcca ggacaccagt     2040

gcaaagcatg ggaccactgt taggagaggc acccaaacag cacctgttcc ataacagaga     2100

gctgccatga gtgatgcaga ggtagcccca tagcctaagg acccacccac cattccttgg     2160

ttcagtgaca caatccgtct accccttcag gtccaatggc gacctgtaat ggcatcttta     2220

cttgtgaggt agccagattc taaatgcaga tagatgtgca tggctcttta gaggcaaaat     2280

tgccagtgct tagctttgtt aaatgcctga tggttcagaa ttccactcac tatttgctgt     2340

tgccccaaag agacaagttc aagacaagtt catagatgca ctgtctgtgg atgcttaaca     2400

aaagcggctg gaagcaagat ccagacaact cactggtagg aaagagcaaa ccacacaagg     2460

acagagcaag ggcattcaca cacaaggaaa ggcccaaccc atgtgcagcg tctacccgtg     2520

tgcacctaag gcagagctgg aagggcactg acccagctga aagtggtcgt tattgggggt     2580

tgagacagac agagcaagga gaggtttcag ggggaacctt aattttatca tttgactctg     2640

ccagagagaa tatattgtgt gtaacacaca cttctttaat cctctgcatt aaaatttgca     2700

aatgccttcc atttcaattc ctggatctga gtcaatgact aaactgatcc tccaaaagat     2760

aattctattc ctgatgtgga gccaagttct ctctcgatct ctgtactagg tatccttggc     2820

ctggaaggaa gaaaggcctt cctgctacat caaatggctc agataacttg agaaaggaag     2880

agtcagaatg ttccttgaac tcttctcaga acacaaaatg tgggccaata gaaagtcaat     2940

ttgtttgaga ctttggtagg tgacacatca ccccaccaca gtttctacca gcttccaagg     3000

acagcccacg tgctggaact ttggcctgat gtctgagatc ctgtgacaag caatccctcg     3060

ggacaggcag tgggtgattt tagaggacag ggctgcagta agcaaggacc aggctagggt     3120

agaacaagaa tccagtgttg tctgggagca gagctggtct gagagacagg ggagagggtg     3180

gctgctaagg tctaagccag aggtggaggg gaagtcatag tgtcttctat agacctctct     3240

tcacctttgt tccagtcagg gctttaggat tgacctaact agaacatcag gaaatgaaga     3300

aataataggc atatacagaa aagctggggt tgagtgagtc atgtatcctt atgaagacat     3360

atcagcctgt cctaaaactc agaaagttta atgtatacag tttaagtggg agccaggcta     3420

gctagcaggt ctctgtaggg tagcatcctc aggatgct                             3458


<210>  8
<211>  1974
<212>  DNA
<213>  Mus musculus

<400>  8
aagtctccag ggcagagagg gagtcaactc attggcgctt gagtcggcaa agaaatcaag       60

atggccaaag ttcctgactt gtttgaagac ctaaagaact gttacagtga aaacgaagac      120

tacagttctg ccattgacca tctctctctg aatcagaaat ccttctatga tgcaagctat      180

ggctcacttc atgagacttg cacagatcag tttgtatctc tgagaacctc tgaaacgtca      240

aagatgtcca acttcacctt caaggagagc cgggtgacag tatcagcaac gtcaagcaac      300

gggaagattc tgaagaagag acggctgagt ttcagtgaga ccttcactga agatgacctg      360

cagtccataa cccatgatct ggaagagacc atccaaccca gatcagcacc ttacacctac      420

cagagtgatt tgagatacaa actgatgaag ctcgtcaggc agaagtttgt catgaatgat      480

tccctcaacc aaactatata tcaggatgtg gacaaacact atctcagcac cacttggtta      540

aatgacctgc aacaggaagt aaaatttgac atgtatgcct actcgtcggg aggagacgac      600

tctaaatatc ctgttactct aaaaatctca gattcacaac tgttcgtgag cgctcaagga      660

gaagaccagc ccgtgttgct gaaggagttg ccagaaacac caaaactcat cacaggtagt      720

gagaccgacc tcattttctt ctggaaaagt atcaactcta agaactactt cacatcagct      780

gcttatccag agctgtttat tgccaccaaa gaacaaagtc gggtgcacct ggcacgggga      840

ctgccctcta tgacagactt ccagatatca taaaagcagc cttatttcgg gagtctattc      900

acttgggaag tgctgacagt ctgtatgtac catgtacagg aaccttcctc accctgagtc      960

acttgcacag catgtgctga gtctctgtaa ttctaaatga atgtttaccc tctttgtaag     1020

agaagagcaa accctagtgg agccaccccg acatatgata ctatctgtta ttttaaagag     1080

taccctatag tttgctcagt actaatcatt ttaattacta ttctgcatgg cattcttagg     1140

aggatcaaaa agactctaca catattacag atgggttaac aaagggataa aacaactgaa     1200

aagcacactc aatgcatttg gaatataaat tcacagacca atctcactgt gcaccttcgg     1260

cttcaaaatg ccagttgagt aggataaagg tataagaact taatgctgtc attttcaaaa     1320

ggaaggggac aatagctaca tctttcctac ctcagtgggt tttactccag tgagatcatt     1380

tggatgaaat cctcctgtaa cagacctcaa gaaggagaca gactgttgaa tgttattttt     1440

aagttatttt atctatgtat ttataaatat atttatgata attatattat ttatggaaca     1500

tccttaaatc ctctgagctt gacggcaccc tcgcagcagg gttttctagg tggtcagtta     1560

gatgtagtct cctctagagc tccatgctac agacttttac actttttcca cagccacgaa     1620

gctctccgta cattcctgca cttgggagcc ctttcatcat gatcttaatc tgtgctgttt     1680

actttgtgca tctaaaatga taattgagtc agtctttctc cctcccgtcc ttaaagctgt     1740

ctgggtattc ttacatcatt cagtctcacc tgtaactaac accaaccatc taaagatgga     1800

aagagcttaa ctgtgacaac cacatcactg atacctgaag tttcttttct agaatgtaat     1860

cagtgtttcc cctggattcc aatttttttt tcaaaccaca gtgtcatgta actatcaaca     1920

ataacaatca actcattatt attaatcata attaaataaa acaggtttga gctg           1974


<210>  9
<211>  270
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Lys Val Pro Asp Leu Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Asp Tyr Ser Ser Ala Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr Asp Ala Ser Tyr Gly Ser Leu His Glu Thr Cys Thr 
        35                  40                  45              


Asp Gln Phe Val Ser Leu Arg Thr Ser Glu Thr Ser Lys Met Ser Asn 
    50                  55                  60                  


Phe Thr Phe Lys Glu Ser Arg Val Thr Val Ser Ala Thr Ser Ser Asn 
65                  70                  75                  80  


Gly Lys Ile Leu Lys Lys Arg Arg Leu Ser Phe Ser Glu Thr Phe Thr 
                85                  90                  95      


Glu Asp Asp Leu Gln Ser Ile Thr His Asp Leu Glu Glu Thr Ile Gln 
            100                 105                 110         


Pro Arg Ser Ala Pro Tyr Thr Tyr Gln Ser Asp Leu Arg Tyr Lys Leu 
        115                 120                 125             


Met Lys Leu Val Arg Gln Lys Phe Val Met Asn Asp Ser Leu Asn Gln 
    130                 135                 140                 


Thr Ile Tyr Gln Asp Val Asp Lys His Tyr Leu Ser Thr Thr Trp Leu 
145                 150                 155                 160 


Asn Asp Leu Gln Gln Glu Val Lys Phe Asp Met Tyr Ala Tyr Ser Ser 
                165                 170                 175     


Gly Gly Asp Asp Ser Lys Tyr Pro Val Thr Leu Lys Ile Ser Asp Ser 
            180                 185                 190         


Gln Leu Phe Val Ser Ala Gln Gly Glu Asp Gln Pro Val Leu Leu Lys 
        195                 200                 205             


Glu Leu Pro Glu Thr Pro Lys Leu Ile Thr Gly Ser Glu Thr Asp Leu 
    210                 215                 220                 


Ile Phe Phe Trp Lys Ser Ile Asn Ser Lys Asn Tyr Phe Thr Ser Ala 
225                 230                 235                 240 


Ala Tyr Pro Glu Leu Phe Ile Ala Thr Lys Glu Gln Ser Arg Val His 
                245                 250                 255     


Leu Ala Arg Gly Leu Pro Ser Met Thr Asp Phe Gln Ile Ser 
            260                 265                 270 


<210>  10
<211>  2017
<212>  DNA
<213>  Homo sapiens

<400>  10
aagctgccag ccagagaggg agtcatttca ttggcgtttg agtcagcaaa gaagtcaaga       60

tggccaaagt tccagacatg tttgaagacc tgaagaactg ttacagtgaa aatgaagaag      120

acagttcctc cattgatcat ctgtctctga atcagaaatc cttctatcat gtaagctatg      180

gcccactcca tgaaggctgc atggatcaat ctgtgtctct gagtatctct gaaacctcta      240

aaacatccaa gcttaccttc aaggagagca tggtggtagt agcaaccaac gggaaggttc      300

tgaagaagag acggttgagt ttaagccaat ccatcactga tgatgacctg gaggccatcg      360

ccaatgactc agaggaagaa atcatcaagc ctaggtcagc accttttagc ttcctgagca      420

atgtgaaata caactttatg aggatcatca aatacgaatt catcctgaat gacgccctca      480

atcaaagtat aattcgagcc aatgatcagt acctcacggc tgctgcatta cataatctgg      540

atgaagcagt gaaatttgac atgggtgctt ataagtcatc aaaggatgat gctaaaatta      600

ccgtgattct aagaatctca aaaactcaat tgtatgtgac tgcccaagat gaagaccaac      660

cagtgctgct gaaggagatg cctgagatac ccaaaaccat cacaggtagt gagaccaacc      720

tcctcttctt ctgggaaact cacggcacta agaactattt cacatcagtt gcccatccaa      780

acttgtttat tgccacaaag caagactact gggtgtgctt ggcagggggg ccaccctcta      840

tcactgactt tcagatactg gaaaaccagg cgtaggtctg gagtctcact tgtctcactt      900

gtgcagtgtt gacagttcat atgtaccatg tacatgaaga agctaaatcc tttactgtta      960

gtcatttgct gagcatgtac tgagccttgt aattctaaat gaatgtttac actctttgta     1020

agagtggaac caacactaac atataatgtt gttatttaaa gaacacccta tattttgcat     1080

agtaccaatc attttaatta ttattcttca taacaatttt aggaggacca gagctactga     1140

ctatggctac caaaaagact ctacccatat tacagatggg caaattaagg cataagaaaa     1200

ctaagaaata tgcacaatag cagttgaaac aagaagccac agacctagga tttcatgatt     1260

tcatttcaac tgtttgcctt ctacttttaa gttgctgatg aactcttaat caaatagcat     1320

aagtttctgg gacctcagtt ttatcatttt caaaatggag ggaataatac ctaagccttc     1380

ctgccgcaac agttttttat gctaatcagg gaggtcattt tggtaaaata cttcttgaag     1440

ccgagcctca agatgaaggc aaagcacgaa atgttatttt ttaattatta tttatatatg     1500

tatttataaa tatatttaag ataattataa tatactatat ttatgggaac cccttcatcc     1560

tctgagtgtg accaggcatc ctccacaata gcagacagtg ttttctggga taagtaagtt     1620

tgatttcatt aatacagggc attttggtcc aagttgtgct tatcccatag ccaggaaact     1680

ctgcattcta gtacttggga gacctgtaat catataataa atgtacatta attaccttga     1740

gccagtaatt ggtccgatct ttgactcttt tgccattaaa cttacctggg cattcttgtt     1800

tcaattccac ctgcaatcaa gtcctacaag ctaaaattag atgaactcaa ctttgacaac     1860

catgagacca ctgttatcaa aactttcttt tctggaatgt aatcaatgtt tcttctaggt     1920

tctaaaaatt gtgatcagac cataatgtta cattattatc aacaatagtg attgatagag     1980

tgttatcagt cataactaaa taaagcttgc aacaaaa                              2017


<210>  11
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 
        35                  40                  45              


Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 
    50                  55                  60                  


Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 
65                  70                  75                  80  


Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 
                85                  90                  95      


Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 
            100                 105                 110         


Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 
        115                 120                 125             


Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 
    130                 135                 140                 


Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 
145                 150                 155                 160 


Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 
                165                 170                 175     


Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 
            180                 185                 190         


Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 
        195                 200                 205             


Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 
    210                 215                 220                 


Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 
225                 230                 235                 240 


Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 
                245                 250                 255     


Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 
            260                 265                 270     


<210>  12
<211>  8704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 112775067-112783770 of NCBI accession 
       number NC_000002.12

<400>  12
atggccaaag ttccagacat gtttgaagac ctgaagaact gttacaggta aggaataaga       60

tttatctctt gtgatttaat gagggtttca aggctcacca gaatccagct aggcataaca      120

gtggccagca tgggggcagg ccggcagagg ttgtagagat gtgtactagt cctgaagtca      180

gagcaggttc agagaagacc cagaaaaact aagcattcag catgttaaac tgagattaca      240

ttggcaggga gaccgccatt ttagaaaaat tatttttgag gtctgctgag ccctacatga      300

atatcagcat caacttagac acagcctctg ttgagatcac atgccctgat ataagaatgg      360

gttttactgg tccattctca ggaaaacttg atctcattca ggaacaggaa atggctccac      420

agcaagctgg gcatgtgaac tcacatatgc aggcaaatct cactcagatg tagaagaaag      480

gtaaatgaac acaaagataa aattacggaa catattaaac taacatgatg tttccattat      540

ctgtagtaaa tactaacaca aactaggctg tcaaaatttt gcctggatat tttactaagt      600

ataaattatg aaatctgttt tagtgaatac atgaaagtaa tgtgtaacat ataatctatt      660

tggttaaaat aaaaaggaag tgcttcaaaa cctttctttt ctctaaagga gcttaacatt      720

cttccctgaa cttcaattaa agctcttcaa tttgttagcc aagtccaatt tttacagata      780

aagcacaggt aaagctcaaa gcctgtcttg atgactacta attccagatt agtaagatat      840

gaattactct acctatgtgt atgtgtagaa gtccttaaat ttcaaagatg acagtaatgg      900

ccatgtgtat gtgtgtgacc cacaactatc atggtcatta aagtacattg gccagagacc      960

acactgaaat aacaacaatt acattctcat catcttattt tgacagtgaa aatgaagaag     1020

acagttcctc cattgatcat ctgtctctga atcaggtaag caaatgactg taattctcat     1080

gggactgcta ttcttacaca gtggtttctt catccaaaga gaacagcaat gacttgaatc     1140

ttcaatactt ttgttttacc ctcactagag gtccagagac ctgtctttca ttataagtga     1200

gaccagctgc ctctctaaac taatagttga tgtgcattgg cttctcccag aacagagcag     1260

aaccatccca aatccctgag aactggagtc tcctggggca ggcttcatca ggatgttagt     1320

tatgccatcc tgagaaaggc cccgcaggcc gcttcaccag gtgtctgtct cctaacgtga     1380

tgtgttgtgg ttgtcttctc tgacaccagc atcagaggtt agagaaagtc tccaaacatg     1440

aagctgagag agaggaagca agccagttga aagtgagaag tctacagcca ctcatcaatc     1500

tgtgttattg tgtttggaga ccacaaatag acactataag tactgcctag tatgtcttca     1560

gtactggctt taaaagctgt ccccaaagga gtatttctaa aatattttga gcattgttaa     1620

gcagattttt aacctcctga gagggaacta attggaaagc taccactcac tacaatcatt     1680

gttaacctat ttagttacaa catctcattt ttgagcatgc aaataaatga aaaagtcttc     1740

ctaaaaaaat catcttttta tcctggaagg aggaaggaag gtgagacaaa agggagagag     1800

ggagggaagc ctaatgaaac accagttacc taagaccaga atggagatcc tcctcactac     1860

ctctgttgaa tacagcacct actgaaagaa ctttcattcc ctgaccatga acagcctctc     1920

agcttctgtt ttccttcctc acagaaatcc ttctatcatg taagctatgg cccactccat     1980

gaaggctgca tggatcaatc tgtgtctctg agtatctctg aaacctctaa aacatccaag     2040

cttaccttca aggagagcat ggtggtagta gcaaccaacg ggaaggttct gaagaagaga     2100

cggttgagtt taagccaatc catcactgat gatgacctgg aggccatcgc caatgactca     2160

gaggaaggta aggggtcaag cacaataata tctttctttt acagttttaa gcaagtaggg     2220

acagtagaat ttaggggaaa attaaacgtg gagtcagaat aacaagaaga caaccaagca     2280

ttagtctggt aactatacag aggaaaatta atttttatcc ttctccagga gggagaaatg     2340

agcagtggcc tgaatcgaga atacttgctc acagccatta tttcttagcc atattgtaaa     2400

ggtcgtgtga cttttagcct ttcaggagaa agcagtaata agaccactta cgagctatgt     2460

tcctctcata ctaactatgc ctccttggtc atgttacata atcttttcgt gattcagttt     2520

cctctactgt aaaatggaga taatcagaat cccccactca ttggactgct gtaaagatta     2580

agagtctcag gctttacaga ctgagctagc tgggccctcc tgactgttat aaagattaaa     2640

tgagtcaaca tcccctaact tctggactag aataatgtct ggtacaaagt aagcacccaa     2700

taaatgttag ctattactat cattattatt attattttat tttatttttt tgagatggag     2760

tctggctctg tcacccaggc tggagtgcag tggcgcaatc tcggctcact gcaagctctg     2820

cctcctgggt tcatgccatt ctcctgcctc agcctcctga gtagctggga atacaggcac     2880

ccgccactgt tcccggctaa ttttttgtat ttttagtaga gacggagttt caccgtggtc     2940

tccatctcct cgtgatccac ccaccttggc ctcccaaagt gccgggatta caggcgtgag     3000

ccaccgcgcc cggcctatga ttattattat tattactact actactacct atatgaatac     3060

taccagcaat actaatttat taatgactgg attatgtcta aacctcacaa gaatcctacc     3120

ttctcatttt acataaaagg aaactaagct cattgagata ggtaaactgc ccaatggcat     3180

acatctgtaa gtgggagagc ctcaaatcta attcagttct acctgagtaa aaaaatcatg     3240

gtttctcctc catcccttta ctgtacaagc ctccacatga actataaacc caatattcct     3300

gtttttaaga taatacctaa gcaataacgc atgttcacct agaaggtttt aaaatgtaac     3360

aaaatataag aaaataaaaa tcactcatat cgtcagtgag agtttactac tgccagcact     3420

atggtatgtt tccttaaaat ctttgctata cacataccta catgtgaaca aatatgtcta     3480

acatcaagac cacactattt acaactttat atccagcttt tcttacttag caatgtattg     3540

aggacatttt agagtgcccg tttttcacca ttataagcaa tgcaacaatg aacatctgta     3600

taaataaata ttcatttctc tcacccttta tttccttaga atatattcct agaagtagaa     3660

tttcccagag ccatgaggat ttgtgacgct attgatatgt gccactttgc actctctgtg     3720

acatatataa ttatttttaa tgcattcttt ttttctcaga gtgcattcat ttgaaaacat     3780

agacgggaaa tactggtagt cttccttgtc agttagaaac acccaaacaa tgaaaaatga     3840

aaaagttgca caaatagtct ctaaaaacaa tgaaactatt gcctgaggaa ttgaagttta     3900

aaaagaagca cataagcaac aacaaggata atcctagaaa accagttctg ctgactgggt     3960

gatttcactt ctctttgctt cctcatctgg attggaatat tcctaatatc ccctccagaa     4020

ctattttccc tgtttgtact agactgtgta tatcatctgt gtttgtacat agacattaat     4080

ctgcacttgt gatcatggtt ttagaaatca tcaagcctag gtcagcacct tttagcttcc     4140

tgagcaatgt gaaatacaac tttatgagga tcatcaaata cgaattcatc ctgaatgacg     4200

ccctcaatca aagtataatt cgagccaatg atcagtacct cacggctgct gcattacata     4260

atctggatga agcaggtaca ttaaaatggc accagacatt tctgtcatcc tcccctcctt     4320

tcatttactt atttatttat ttcaatcttt ctgcttgcaa aaaacatacc tcttcagagt     4380

tctgggttgc acaattcttc cagaatagct tgaagcacag cacccccata aaaatcccaa     4440

gccagggcag aaggttcaac taaatctgga agttccacaa gagagaagtt tcctatcttt     4500

gagagtaaag ggttgtgcac aaagctagct gatgtactac ctctttggtt ctttcagaca     4560

ttcttaccct caattttaaa actgaggaaa ctgtcagaca tattaaatga tttactcaga     4620

tttacccaga agccaatgaa gaacaatcac tctcctttaa aaagtctgtt gatcaaactc     4680

acaagtaaca ccaaactagg aagatcttta ttatctctga taacatattt gtgaggcaaa     4740

acctccaata agctacaaat atggcttaaa ggatgaagtt tagtgtccaa aaacttttat     4800

cacacacatc caattttcat ggcggacatg ttttagtttc aacagtatac atattttcaa     4860

aggtccagag aggcaatttt gcaataaaca agcaagactt tttctgattg gatgcacttc     4920

agctaacatg ctttcaactc tacatttaca aattattttg tgttctattt ttctacttaa     4980

tattatttct gcaattttcc caatattgac atcgtgtatg tatttgccat ttttaatatc     5040

actagacaat tcaatcaggt tgctacgttg gtcccttggg tttactctaa atagcttgat     5100

tgcaaatatc tttgtatata ttattgtttt ttctcctatc ttgtaatttc tttgagcaca     5160

tcccaaagag gaatgcctag atcaatgggc acaaataatt tgacagctct tattaaacat     5220

tattctgtaa gtaaaaactg aactactttt cagtatcact agcaacatat gagtgtatca     5280

gcttcctaaa cccctccatg ttaggtcatt atgaacttat gatctaacaa attacagggt     5340

cttatcccac taatgaaatt ataagagatt caacacttat tcagccccga aggattcatt     5400

caacgtagaa aattctaaga acattaacca agtatttacc tgcctagtga gtgtggaaga     5460

cattgtgaag gacacaaaga tgtatagaat tccattcctg acttccaggt atttacacca     5520

taggtgggga cctaactaca cacacacaca cacacacaca cacacacaca cacacaccat     5580

gcacacacaa tctacatcaa cacttgattt tatacaaata caatgaattt actttctttt     5640

tggttcttct cttcaccagt gaaatttgac atgggtgctt ataagtcatc aaaggatgat     5700

gctaaaatta ccgtgattct aagaatctca aaaactcaat tgtatgtgac tgcccaagat     5760

gaagaccaac cagtgctgct gaaggtcagt tgtcctttgt ctccaactta ccttcattta     5820

catctcatat gtttgtaaat aagcccaata ggcagacacc tctaacaagg tgacactgtc     5880

ctctttcctt cctaccacag cccccacctg cccaccccac tcccattgat tccagaggcg     5940

tgcctaggca ggctctatga gaaaatataa cagagagtaa gaggaaaatt accttctttc     6000

tttttccttt ccctgcctga ccttattcac ctcccatccc agagcatcca tttattccat     6060

tgatctttac tgacatctat tatctgacct acacaatact agacattagg acaatgtggc     6120

ctgcctccaa gaaactcaaa taagccaact gagatcagag aggattaatc acctgccaat     6180

gggcacaaag caacaagctg ggagccaagt cccaaaatgg ggcctgctgc ttccagttcc     6240

cctctctctg cattgatgtc agcattatcc ttcgtcccag tcctgtctcc actaccactt     6300

tccccctcaa acacacacac acacaacagc cttagatgtt ttctccactg ataagtaggt     6360

gactcaattt gtaagtatat aatccaagac cttctattcc caagtagaat ttatgtgcct     6420

gcctgtgctt ttctacctgg atcaagtgat gtctacagag tagggcagta gcttcattca     6480

tgaactcatt caacaagcat tattcactga gagccttcta tttttcaggc atagtgccaa     6540

cagcagtgtg gacagtggtg catcaaagcc tctagtctca tagaacttag tcttctggag     6600

gatatggaaa acagacaacc caaacaacca acaaaagagc aagatgctgc aaaaaaaaaa     6660

aaaaatgaat agggtgctaa gatagagaaa agtgggagag tgctatttag acaaagtggt     6720

aaaaacaaag ccccttgtga gatgagagct gccgacagga gggggcgggt catggttgtg     6780

ggtttttggg taggacattc agaggagggg gcgggtcgtg gttgtgggtt tttgggtagg     6840

acattcagag gagggggcgg gtcgtggttg tgggtttttg ggtaggacat tcagaggagg     6900

gggcgggtcg tggttgtggg tttttgggta ggacattcag aggagggggc gggtcgtggt     6960

tgtgggtttt tgggtaggac attcagagga gggggcgggt cgtggttgtg ggtttttggg     7020

taggacattc agaggagggg gcgggtcgtg gttgtgggtt tttgggtagg acattcagag     7080

gagggggcgg gtcgtggttg tgggtttttg ggtaggacat tcagaggagg gggcgggtcg     7140

tggttgtggg tttttgggta ggacattcag aggagggggc gggtcgtggt tgtgggtttt     7200

tgggtaggac attcagagga gggggcgggt cgtggttgtg ggtttttggg taggacattc     7260

agaggagggg gcgggtcgtg gttgtgggtt tttgggtagg acattcagag gagggggcgg     7320

gtcatggttg tgggtttttg ggacattcag aggagtctga atgcacccag gcctacaact     7380

tcaagatggt aaaggacagc tccaaggatc agaagaagca ttcttggaac tggggcattt     7440

tgagaaggag gaaaaatatg cagagactag tgcttgcaga gcttgcattt ggatttcatt     7500

tgaggtacaa tgaaaaccca ttaatgggtt tcacacagtg caatggcctg acctcactta     7560

tatttcctaa aatagaaaac agatcagaag gaaggcaata gagaagcaga aagtccaatg     7620

aggaggtttc acagcagtca tgggggtggg gtaaggaaaa gaagtggaaa gaaacagaca     7680

gaattgggtt atattttgga gatagaacca acagaaggaa gaggagaaac aacatttact     7740

gagaagggaa aaagtaggag aggaataggt ttgggaaata aatcctgctg acattggaaa     7800

ccccaaggaa gcctcaaaag tatatttact tgctttagat ttaaaagaat aggaaagaag     7860

catctcaact tggaatttga aatctatttt tccataaaag tattgttaaa ttctactcat     7920

actcacaaga aaagtacatt ctaaagagta tattgaaaga gtttactgat atacttagga     7980

attttgtgtg tatgtgtgtg tgtgtatgtg tgtgcgtgtg tttaaccttc aattgttgac     8040

ttaaatactg agataaatgt catctaaatg ctaaattgat ttccaaaggt atgatttgtt     8100

cacttggaga tcaaaatgtt tagggggctt agaatcactg tagtgctcag atttgatgca     8160

aaatgtctta ggcctatgtt gaaggcagga cagaaacaat gtttccctcc tacctgcctg     8220

gatacagtaa gatactagtg tcactgacaa tcttcataac taatttagat ctctctccaa     8280

tcaactaagg aaatcaactc ttattaatag actgggccac acatctacta ggcatgtaat     8340

aaatgcttgc tgaatgaaca aatgaatgaa gagcctatag catcatgtta cagccatagt     8400

cctaaagtgc tgtttctcat gaaggccaaa tgctaaggga ttgagcttca gtcctttttc     8460

taccatcttg ttctctaaca gaattctctt cttttcttca taggagatgc ctgagatacc     8520

caaaaccatc acaggtagtg agaccaacct cctcttcttc tgggaaactc acggcactaa     8580

gaactatttc acatcagttg cccatccaaa cttgtttatt gccacaaagc aagactactg     8640

ggtgtgcttg gcaggggggc caccctctat cactgacttt cagatactgg aaaaccaggc     8700

gtag                                                                  8704


<210>  13
<211>  4800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  13
tgtctcttca tgtttgtgcc tctgaacacc tctcccttga ggtagacaag tgaatagtta       60

atttcaggat ccctacgtcc tcatgaatgt caaactctgt aaacgctcac agccagaaag      120

aacatagtct tgaattcaca taaatgcata gcccctgtat gccttgaact catttctaca      180

cccctgctga cacctaacag agtataaatg ccctgtaagt agccattata ctgtattgtc      240

tcctgaattc aacacagatg cttctcctcc ccatccccaa gtacttctgc cctcacttgg      300

ttcagtctgc aaatgcagaa cccagagaca caaagagcca aactttcccc cagaaaattc      360

agagttgtgc ttctctcggc gttcaagtga ttcctttcag atccgggtat catgtgctga      420

ttttaaggtt gattctgaag gcatttacaa atgtttctca ccttcatggt acagtgacaa      480

gctgtgccag agtccacagc catactccac ttccaaacat cattcatcac aatggtggcc      540

tgccttctgt tttcagggta tcacagaata aaaaagattt cactagacaa aggaaaggaa      600

aaacctttct catctttggg gcggttgttg tttgtttgtt tgtttgttgt ggtaagtgca      660

ttgtttgagc acatgtgcat acaatttgtg tacctgtgag taccgaggcc cgaggttgct      720

atcagagact gtcctcagtc actcctctta ttgtctgagg cagcgtcttt taatgtaacc      780

aagagcttgc agtttagtta gtgtagctat cccagttgct ccagattccc tgggtctatt      840

ttctgatact gccacggcca cccagaattt atgtgggtta taggtatctg aactccagtc      900

ctcttgctcc tctggaagtc cctttaactt ctgagccaac tcccctagcc atcttttgtt      960

ttttataaaa tcgtagaatt actcagagta ccttaaagtc gatgcatttc agcaaagact     1020

tgccagtgac agtgagaaag tattctagga ttcagactat aaatgagatc taatttcatc     1080

agaatctgag tttcaagttc aggctgtgtc tgagtcttgg tttctgtgac cttcacttgg     1140

tcatttcttt cttccaaggt cttcagctgc ataaggacac aggaatggca catgagtatg     1200

tgcagctgga ggctgaactg agagcacact gttaacctta aggcattgtc acatggaaag     1260

catcactgag attcttaggg caagtgtgac cgtgcatggc tgggtctata acccagcccc     1320

caggaggctg aagcaggagg agtctttgag agcagattca gacgcacaat gagaccctgt     1380

caagaacaaa agacagatgc tgggcagtgg tggcgcacgc ctttaatccc agcacttggg     1440

aggcagaggc agtcgaattt ctgagttcga agccagcctg gtctacagag tgagttccag     1500

gacagccagg gctacacaga gaaaccctgt ctcgaaaacc gaaaaaaaga aaaaagaaag     1560

aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag     1620

aaagaaagaa agaaagaaag aaagaaagaa aaaaagaaag agaacaaaag acaaagagaa     1680

gagagaagga tgagatggag ggaatgaagg gaagtagaga gagaaagaac aaggcagaca     1740

gacagatctt ttggagccat aacatcaggg cttacaaagc aaatccactc acctaccaac     1800

acatgtcatt ttgtcttgca aaatgcttaa ttttgtggct tctgaaagga aaattattaa     1860

tgtttggcaa agcctatggt acagaataca atatttattt ctgaattatt taggaagcac     1920

tgagccaaac acatcaggcc cagtaaagcc ctgcccagtg ctgtcctctc tcccttccct     1980

aaaaggattg gtttagatgc tacagctctc cctctctgaa cctcctgcat catcttttcc     2040

cctcgaaacc actttccaag aaggccatat gaaagagtag gttgagagat acacagaccc     2100

aaattggctg tttctcaacc aaactctcat ttggggaatt ctctacagca caggaatgaa     2160

gatggagctg gactggctgt tgctaaagac agtagaacca agggtgtttt cccaaattgc     2220

caaagaggtg ctgtgcactg ttctcagaaa ccaaatggct ttggtgcctc ggtagtgacc     2280

ttcactcaaa aatgtcttcc ctagtgaagg tttcaaagcc ctgttttcct aagattccta     2340

ttttctgctg tgaactaagg catcatggtg atgactccac agactctcca gtgactgagg     2400

ccatcattag tgtcattatt tttgtttagc tgcatctcca tagcagccca cattcacaat     2460

gcaccttgca attgtttctt agtgattatc ctcacaaggt gtccgacagg cagaagatga     2520

caagattagc atttctgtgt tgcctagagc agaaggcagg ttaaggaggg atgtggagct     2580

agctagctgc tgtcactgct catagatgtt tagagacacc cacccgagct ttggctccag     2640

tctgcttctg tgcttggact acctttacgt aggatcactc atctttgagt tttgtttgta     2700

aatacagcat gaggagggac agactgggca gccacattgg aattggagcg tttacacttg     2760

cagtagaagc aatgaacatc taaagagctc cactccatgc tttaaaaggg ctagagggac     2820

tgggtcaacc aacacacata agctgcttta cccctctcgc cccaccgctt ctggtttggt     2880

ttgggtttta tcccgtgttt cagtggtttg cttttctctc tttgccatta tttttctttc     2940

cttgtctacc acccacttcc tttatttaaa agttacatgg cttaaatgcc aactagaaaa     3000

gctgaaacac tgatttgctg agagtctggt gccctacctc ttaagactgg cctggcgtct     3060

gggaactgaa actatctcta ataaaactga ccgggcagtg ttgctccatg taagaatcca     3120

taccttcctc tcccatagcc tccactctgg agctgaggca ctatcatggc tgggcctttg     3180

tccctgcctc caaaagtgag cagctgttct cactcagctc tgatctaccc agaggtacac     3240

tagactttgt gtttaggtgg tagggcaagg ttactttgcc ataatgtggc tgaggcaggg     3300

aactctctcc tgaagctgtc atctctgtag gaagtgtgtt tatgttatcc aaaggagtaa     3360

gaggacccag atctttaggg caagtgtcac ttttacctcc tccaccttta accataaggt     3420

tattgtttca tactcagact gataatttat tcaagcagat tttcccctac aaagaggagg     3480

gaagaagctc attttccctc aaatgcctta gctgccaagt atcctgccca tccatattca     3540

gtcctggggc acaataaaca agttagccca aaacacaaag tacagctatg gagctccagt     3600

ccttgtttgg ctttcactct gatttgagga tttcttcctt cctcttccac tggtgggctt     3660

cctgccgctc ttcccgtttt gtaagactac atgtctctaa tcacatggat tagcaagaaa     3720

taggctgatc aagtcaacgg cccgtggaat ctttgcaagc aacattatta ccaagtgtat     3780

aatctgtcct tctggccggt atcaggcaga atgaacatag aaagatacta agcagaattg     3840

tttcctgtaa attcccagtg acacacacat ggccactcct acctgcttga ggaagactat     3900

aaaaaggcag agaagcctga ctcagactta agtctccagg gcagagaggg agtcaactca     3960

ttggcgcttg agtcggcaaa ggtattgtcc ttatcacgtc taaggctatg aaaattgtct     4020

tttgtttgct ccttgactgt cctctctcaa ggcaccttgt gtaaggctat ggttttttct     4080

cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct tcttcttctt     4140

tctccttctc cttctcctcc ttctccttct ccttctcctc ctccttctct tctcctcctc     4200

ctcctcctcc tcctcctcct cctcctcctc ctcctcctcc tcctcctcct cctcctcctc     4260

ctccttctcc ttcttctaat ttagtacagg ggctgggatg agagatttaa gaaaagaatt     4320

ctctttctag tgacagggaa cttagggagc agctgaacaa gattcatggg agggagtcta     4380

ccagcaaagt cgaatctttt tctggagatt ggacgtctct actggcaaaa atgagagagg     4440

ccatcaggtt cccattctcc cttgcctata tataaggcag acaccccact ctggtgattt     4500

taattttgtc cttaatatat tcacctatta aatgcctact atgtgtgatg caatagactg     4560

aacacaaaga ataccagggt agagaaaaca ttctaaaaca aaagtacaag ttagtggagg     4620

agatagaagc atacagaaat aatgtaaggg agtacagaga agaatagagg aaattctggg     4680

catgtgataa gtcactcatt gtaatttctc aagagcaaag tagggtcatt gcccttgcaa     4740

gcacggggtt tagaagtgga ctgagctgac agccactggt gttctcttac agaaatcaag     4800


<210>  14
<211>  3899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  14
tgagaacaag gccttctaaa ataactgagc aaaacccata tgcgttcaca gagcctgaag       60

cctgaagcag cagccgcagg gcctacacag gtctgcccag gtttctgtac acacactcta      120

gctttcagtt tatgctctga tgggactcct gaatggaaat gagtaagtct ctgattcttc      180

tgcctactct tggagctctt tcatttttct gttggcatag cttgtccaac ttatatatga      240

tgatttctgt tttatcttac tatattttgc tacattttgt tgttttcccc aaaaaatgca      300

tttaaaaaaa attcaggttc catagctttt ctttcttttt tttttttttt gctagctgcc      360

agtattcaca gatagatagc actgaaaatt ataatatttc caggctcagt taaaggatac      420

aatccatatt cagtacatgt gtatgccgat gtagatgtcc atacaaactc accatataat      480

gtaccaccaa aaccaagtag tggttttaga gacaatacag caggttagaa gctgctttcc      540

tgtgacctaa tgaaaaagaa agtcagaatc aggagtaata gactctattt tagaaagtgg      600

ggttggaaat tcacagaaac aataattgaa cacctgaaat gtgcagtaac ccttcaccca      660

aattcttgta catagccccg ataagacgtg ttgagctttg gtggtatcca agcttttgtc      720

tgtctgcagt aagtagccat gtgttacatc tcctcaggga aagtcttgtc acacaagtgg      780

atgtcgggat gtcagaccct atggagctag agttacaggc agatgtgtta tgtaatatgg      840

gtgctgggaa ccaactctgg tggcctgcca gagcactgca tgctccttac cccagccatc      900

tcagcgcttt ttatcatatt aaaaaacaaa aacaaaagca aaaacttttg tgattttttt      960

tttattctcc ttcactcacc tgataatgtt taggtatgcc agtgataacc ttttccttct     1020

ctttccttca tgattttttt tttctttcta gcaggccttt gttagcattt taactttacc     1080

ttgtagatgt ttttctgttt aaataaacta ttatgtttcc atgttttatt tccattctta     1140

aatttatata attctgttct ttacattttc tattaggaaa tctttgttat tcttttaaaa     1200

actcttctaa ccccttgccc ttttctcttc ccaccataac atccttctcc aataaatatc     1260

ttttacgaga tttgctgcct catatgactt tcgcgttgga agaagccaag aagcaattga     1320

cagaggaagg gaagaaacaa agaagtggag cggggcagag gctcctgagc tcctgggctg     1380

agctggagat accctcccct gggaactgca ctgcctcagc tgacgaggct tcctctcaaa     1440

gctgtgtggt tccccggctc tgatgtctca gggtgtcctt ccacaggaat accttctgac     1500

cctcagagct ctgtggtttc tgggtttccg agtctcaggg tgcctttcca aggggacact     1560

gtcccacctc agagctgtgt ggctcctgag ctcctgtgtc ttaggatgcc cttcccttga     1620

gacacttttg acagattgcg ccattttgac agctcccgcg agctgctcag ggactacacg     1680

gagttatgtt gtttctgtcc ggtattcggc tacaagaatg agaacaataa ctgatacgga     1740

ccattttcgt ttggcatgct attatttgca gccaaagcca gcctaactga tagcacagag     1800

acttaggctc cggcttgttt ctccccgttt cttcaactgt cacaaccgtc cttaacccaa     1860

atttggctac aattagagcc actcctccgc cagccagcat cacccaccag ctcccacctc     1920

agaggcaccg ctgcggaagt gacctagcca tagggcgggc cttctcagaa actctccaat     1980

cgcagagcct caggggaggt ccccagtggg aatcgccgaa tgtccatttc ctgttatccc     2040

gccctctccg tctttttatt ggcgaatttc aaagtcgcgg aagccaatag gagcgtccag     2100

acgggcgccc ggttctcgta ctagaacaag gcgcgccctt tgaaggaaga aactgtcgcc     2160

gtagagccat ggtggggccc ggccccactg ccagcgcagc cgcgggtaag tgtggtcggc     2220

agcctccaga agctgccagg cctcccccgc ctgcttcagt ctcccccgag ctcagttagg     2280

ttaaggacgc tggacccggg ccacggcgag gagcggcgcg ctccgttgcc gcagggggac     2340

acccctgcat tgctagttat ggccagaact ttgacagcag tcaggtggca ggttcggccc     2400

cagtccgagt ctctgcaggt tcactgataa aatgtgcgct gtctggaggt tgattgataa     2460

actgtgggct gaggcttaag gatgctgtga accctggcct ccgagggacc tggagccctt     2520

tctacctctc cagtatgccc ctcccccgtg tcacctttga gatgcacact ctgtcctcac     2580

ttatgggcct gcggttctgc gcaccgtcct aggcacacaa tttgtaactc aagggttaaa     2640

aaaaaaagtc ttgattccaa atcctggctt tgctgcacat tagtgggtaa atttaagcct     2700

gtcacttcat ctgagtttca aacagccaaa tacctcatag gattgatggt tagtgtaaac     2760

agcttagtaa agagcttggc accaggctga taccgttggt attgaaagca agcataacag     2820

gactggtgac tttatcaaag ccaaaatagc tacagggaag tatcatattt aaagatataa     2880

agggttttct gtaatgtttt tggtgtttgc tcgtgtccat gttttacaga agaacggtgg     2940

cagaagctcc aggagtacct ggcagccaag ggaaagctaa aggaccccaa cgccaagtga     3000

gtttaccttc ccatagttac actggctttg ttgccccggt tgctaacagc aatgaacgga     3060

ccagcccttc tgtttccagt ctgtttgact tgcatcatgg tgaatcctgt aataacaaaa     3120

ggagcatttc agtccttgat ttcaggcatg acttaaaaaa caaaacaaaa caaaaaacca     3180

gcaaccccta ggcagtgctg tctattggca gaaatttaag catttttttt cctaacagtc     3240

tccaaaggaa ggaaggctct acactacact gttacccaca tctctggaag ctcttctggt     3300

tccttctttc tcctgggaaa gttggttccc agcagcgcag attttgatca agaaactgga     3360

gggcatttct atggtgtgtg cttacgaaga caggagagtt ggttatggtc agtccacaac     3420

agtggcatgc cagcgtcctc ccaacttgtc ctttggtgtt ccctgggcat gtatttgagg     3480

tggacagaac atcctttgct tttctcagca ctgtaccatc tttgccctgt tatttctctc     3540

tcttgcttag cagggtgtat ttgcctccca cttgagtagc tcggttggtg tgtgtatgcc     3600

agagggggat tttgggtgtc ttgctctaac gctgtccacc ttattcccat aagaccggat     3660

tgctcactga acccgaagct cactgcttag gttaagcagg ctggccagca ctctctctcc     3720

catgatccac tcatccctgt cccctagtgc ctagggttag agggatactc accgtgcctg     3780

atttaatgtg gatgccggag atcttcctag cccaggtcat tttaccttgg gtttttctca     3840

cctctacttc ctggattaaa tgaaccaaaa ttgttttctc aacataccca taatgtctc      3899


<210>  15
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the human DNA fragment in the 
       "A fragment" and the mouse sequence

<400>  15
actttctttc ttcacacagg tgtctgaagc agctatggca gaagtacctg agctcgccag       60

tgaaatgatg gcttattaca g                                                 81


<210>  16
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   connection between the downstream of the human DNA fragment and 
       the mouse sequence

<400>  16
ccatgcaatt tgtgtcttcc taaagtatgg gctggactgt ttctaatgcc ttccccaggg       60

c                                                                       61


<210>  17
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the Neo cassette and the mouse
       sequence

<400>  17
tttggcaaca ggaagatctc tgggcttgac agcagccatc tactagggtt aacgaattcc       60

gaagttccta ttctctagaa agtataggaa cttcaggtct gaaga                      105


<210>  18
<211>  170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the downstream connection of the Neo cassette

<400>  18
cttcgaagtt cctattctct agaaagtata ggaacttcat cagtcaggta cataattagg       60

tggatccaat attgatatcg gtacctatcc acatctagca aggaaccctg tctcaaaaat      120

taaggtggaa aataattgag gaagacaact gattttgatc tctggtctcc                 170


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
caggacatag cgttggctac                                                   20


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
ttagccaaca ggctacagaa ccacg                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  21
catccataac caaggctgcc agtca                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  22
aattgctctg accacttact gcccc                                             25


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  23
cttgttcctt gctcttcacc agccc                                             25


<210>  24
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  24
cggccaatgc atcttctgtg tttcaa                                            26


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  25
ggatcggcca ttgaacaaga t                                                 21


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  26
cagaagaact cgtcaagaag gc                                                22


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
cttcctggga aacaacagtg gtc                                               23


<210>  28
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
gagagtgctg cctaatgtcc ccttg                                             25


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
gcccctggaa actaggtact tcaag                                             25


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
tgagcaagag gacctgaatg ag                                                22


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
cattcacatg tgtgtagggg tgga                                              24


<210>  32
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the human DNA fragment in the 
       "A fragment" and the mouse sequence

<400>  32
ggtgttctct tacagaaatc aagatggcca aagttccaga catgtttgaa g                51


<210>  33
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the downstream of the human DNA fragment and 
       the mouse sequence

<400>  33
tactggaaaa ccaggcgtag aagcagcctt atttcgggag tctattcact                  50


<210>  34
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the Neo cassette and the mouse
       sequence

<400>  34
ggagacagga gtcggggaga cagaagggat ggatatcgaa ttccgaagtt cctattctct       60

agaaagtata ggaacttcag g                                                 81


<210>  35
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the downstream connection of the Neo cassette

<400>  35
gaagttccta ttctctagaa agtataggaa cttcatcagt caggtacata attaggtgga       60

tcccactatg tgtgagaaca aggccttcta aaataactga gcaaaaccc                  109


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
gctcgactag agcttgcgga                                                   20


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
gacttggacg agagaaggcg tgag                                              24


<210>  38
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  38
gaagtaaccc tccagaaaag acttcccg                                          28


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  39
gcaacaccag ctgtggtctc tgat                                              24


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  40
ggctttcctg attcttctgt accaagg                                           27


<210>  41
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  41
gacaggacct gactcttact ggttgtat                                          28


<210>  42
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
tcgagagcgc tgtttctcat gaagt                                             25


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
ggctccacta gggtttgctc ttctc                                             25


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
tcttcttctg ggaaactcac ggcac                                             25


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
gttagggaca actggtcagc actca                                             25


<210>  46
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46
tccattcagg agtcccatca gagca                                             25


<210>  47
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
gacaagcgtt agtaggcaca tatac                                             25


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
gctccaattt cccacaacat tagt                                              24


<210>  49
<211>  268
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Met Ala Thr Val Pro Glu Leu Asn Cys Glu Ile Ala Ala Phe Asp Ser 
1               5                   10                  15      


Glu Glu Asn Asp Leu Phe Phe Glu Ala Asp Arg Pro Gln Lys Ile Lys 
            20                  25                  30          


Asp Cys Phe Gln Ala Leu Asp Leu Gly Cys Pro Asp Glu Ser Ile Gln 
        35                  40                  45              


Leu Gln Ile Ser Gln Gln His Leu Asp Lys Ser Phe Arg Lys Ala Val 
    50                  55                  60                  


Ser Leu Ile Val Ala Val Glu Lys Leu Trp Gln Leu Pro Met Ser Cys 
65                  70                  75                  80  


Pro Trp Ser Phe Gln Asp Glu Asp Pro Ser Thr Phe Phe Ser Phe Ile 
                85                  90                  95      


Phe Glu Glu Glu Pro Val Leu Cys Asp Ser Trp Asp Asp Asp Asp Leu 
            100                 105                 110         


Leu Val Cys Asp Val Pro Ile Arg Gln Leu His Cys Arg Leu Arg Asp 
        115                 120                 125             


Glu Gln Gln Lys Cys Leu Val Leu Ser Asp Pro Cys Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Asn Gly Gln Asn Ile Ser Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Thr Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly 
            180                 185                 190         


Thr Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys Thr 
    210                 215                 220                 


Lys Val Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu His Arg Pro Val Phe Leu Gly Asn Ser Asn Gly Arg 
                245                 250                 255     


Asp Ile Val Asp Phe Thr Met Glu Pro Val Ser Ser 
            260                 265             


<210>  50
<211>  270
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Met Ala Lys Val Pro Asp Leu Phe Glu Asp Leu Lys Asn Cys Tyr Ser 
1               5                   10                  15      


Glu Asn Glu Glu Tyr Ser Ser Ala Ile Asp His Leu Ser Leu Asn Gln 
            20                  25                  30          


Lys Ser Phe Tyr Asp Ala Ser Tyr Gly Ser Leu His Glu Asn Cys Thr 
        35                  40                  45              


Asp Lys Phe Val Ser Leu Arg Thr Ser Glu Thr Ser Lys Met Ser Thr 
    50                  55                  60                  


Phe Thr Phe Lys Glu Ser Arg Val Val Val Ser Ala Thr Ser Asn Lys 
65                  70                  75                  80  


Gly Lys Ile Leu Lys Lys Arg Arg Leu Ser Phe Asn Gln Pro Phe Thr 
                85                  90                  95      


Glu Asp Asp Leu Glu Ala Ile Ala His Asp Leu Glu Glu Thr Ile Gln 
            100                 105                 110         


Pro Arg Ser Ala Pro His Ser Phe Gln Asn Asn Leu Arg Tyr Lys Leu 
        115                 120                 125             


Ile Arg Ile Val Lys Gln Glu Phe Ile Met Asn Asp Ser Leu Asn Gln 
    130                 135                 140                 


Asn Ile Tyr Val Asp Met Asp Arg Ile His Leu Lys Ala Ala Ser Leu 
145                 150                 155                 160 


Asn Asp Leu Gln Leu Glu Val Lys Phe Asp Met Tyr Ala Tyr Ser Ser 
                165                 170                 175     


Gly Gly Asp Asp Ser Lys Tyr Pro Val Thr Leu Lys Val Ser Asn Thr 
            180                 185                 190         


Gln Leu Phe Val Ser Ala Gln Gly Glu Asp Lys Pro Val Leu Leu Lys 
        195                 200                 205             


Glu Ile Pro Glu Thr Pro Lys Leu Ile Thr Gly Ser Glu Thr Asp Leu 
    210                 215                 220                 


Ile Phe Phe Trp Glu Lys Ile Asn Ser Lys Asn Tyr Phe Thr Ser Ala 
225                 230                 235                 240 


Ala Phe Pro Glu Leu Leu Ile Ala Thr Lys Glu Gln Ser Gln Val His 
                245                 250                 255     


Leu Ala Arg Gly Leu Pro Ser Met Ile Asp Phe Gln Ile Ser 
            260                 265                 270 


