                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  AUGMENTING ANTIGEN-NEGATIVE CELL DEATH IN ANTIGEN-TARGETED 
       IMMUNOTHERAPIES

<130>  F053-0127PCT / 20-155-WO-PCT

<140>  PCT/US 21/025260
<141>  2021-03-31

<150>  US 63/003,209
<151>  2020-03-31

<160>  178   

<170>  PatentIn version 3.5

<210>  1
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(50)
<223>  (GlyGlyGlyGlySer) sequence can be present or absent

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  2
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(40)
<223>  (GlyGlyGlySer) sequence can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(90)
<223>  (GlyGlyGlyGlySer) sequence can be present or absent

<400>  2

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90  


<210>  3
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(40)
<223>  (GlyGlyGlySer) sequence can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (44)..(70)
<223>  (GlyGlySer) sequence can be present or absent

<400>  3

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    50                  55                  60                  


Gly Gly Ser Gly Gly Ser 
65                  70  


<210>  4
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (5)..(40)
<223>  (GlyGlyGlySer) sequence can be present or absent

<400>  4

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  6

Gly Gly Gly Ser 
1               


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  9

<400>  9
000

<210>  10

<400>  10
000

<210>  11

<400>  11
000

<210>  12

<400>  12
000

<210>  13

<400>  13
000

<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRL1

<400>  14

Thr Ala Ser Ser Ser Val Asn Tyr Ile His 
1               5                   10  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRL2

<400>  15

Thr Ser Lys Val Ala Ser 
1               5       


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRL3

<400>  16

Gln Gln Trp Arg Ser Tyr Pro Leu Thr 
1               5                   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRH1

<400>  17

Asp Tyr Val Val His 
1               5   


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRH2

<400>  18

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRH3

<400>  19

Asp Tyr Arg Tyr Glu Val Tyr Gly Met Asp Tyr 
1               5                   10      


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRL1

<400>  20

Arg Ala Ser Glu Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRL2

<400>  21

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRL3

<400>  22

Gln Gln Ser Lys Glu Val Pro Trp 
1               5               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRH1

<400>  23

Asp Tyr Asn Met His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRH2

<400>  24

Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 CDRH3

<400>  25

Gly Arg Pro Ala Met Asp Tyr 
1               5           


<210>  26
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 variable light chain

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Asn Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Asp Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Asp Gly Thr Arg Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  27
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 variable heavy chain

<400>  27

Glu Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp Tyr 
            20                  25                  30          


Val Val His Trp Leu Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Arg Tyr Glu Val Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD33 variable heavy chain

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser His Pro Leu Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Gln Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H7 (North, Kabat, and Chothia)

<400>  45

Arg Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn 
1               5                   10      


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H7 (North)

<400>  46

Tyr Tyr Ser Ser Arg Leu His Ser 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1H7 (North, IMGT, Kabat, and Chothia)

<400>  47

Gln Gln Asp Asp Ala Leu Pro Tyr Thr 
1               5                   


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 (North)

<400>  48

Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10              


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7 (North)

<400>  49

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H7 (North and IMGT)

<400>  50

Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of 1H7

<400>  51

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp Ala Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  52
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of 1H7

<400>  52

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-HER2 CDRL1

<400>  53

Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala 
1               5                   10      


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-HER2 CDRL2

<400>  54

Ala Ser Tyr Arg Tyr Thr 
1               5       


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-HER2 CDRL3

<400>  55

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-HER2 CDRH1

<400>  56

Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp 
1               5                   10  


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-HER2 CDRH2

<400>  57

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-HER2 CDRH3

<400>  58

Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 CDRL1

<400>  59

Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 CDRL2

<400>  60

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 CDRL3

<400>  61

Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 CDRH1

<400>  62

Asn Tyr Tyr Met Tyr 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 CDRH2

<400>  63

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PD-L1 CDRH3

<400>  64

Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      


<210>  65
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of Avelumab

<400>  65

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  66
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of Avelumab

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of Avelumab

<400>  67

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of Avelumab

<400>  68

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of Avelumab

<400>  69

Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val 
1               5                   10  


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of Avelumab

<400>  70

Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met 
1               5                   10      


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of Avelumab

<400>  71

Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of Avelumab

<400>  72

Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr 
1               5                   10      


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of Atezolizumab

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  74
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of Atezolizumab

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of Atezolizumab

<400>  75

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of Atezolizumab

<400>  76

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of Atezolizumab

<400>  77

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of Atezolizumab

<400>  78

Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10      


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of Atezolizumab

<400>  79

Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of Atezolizumab

<400>  80

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA CDRL1

<400>  81

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp 
1               5                   10      


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA CDRL2

<400>  82

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA CDRL3

<400>  83

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA CDRH1

<400>  84

Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA CDRH2

<400>  85

Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA CDRH3

<400>  86

Gly Trp Asn Phe Asp Tyr 
1               5       


<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of Amatuximab

<400>  98

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  99
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of Amatuximab

<400>  99

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of Amatuximab

<400>  100

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of Amatuximab

<400>  101

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of Amatuximab

<400>  102

Gln Gln Trp Ser Lys His Pro Leu Thr 
1               5                   


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of Amatuximab

<400>  103

Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210>  104
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of Amatuximab

<400>  104

Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln 
1               5                   10              


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of Amatuximab

<400>  105

Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  106

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  107

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  108
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  108

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  109

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  110

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  111

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  (GluAlaAlaAlaLys) can be repeated n times, wherein n is an 
       integer including 1, 2, 3, 4, 5, 6, 7, 8, 9, or more.

<400>  112

Glu Ala Ala Ala Lys 
1               5   


<210>  113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  113

His His His His His His 
1               5       


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  114

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  115

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  116

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  117
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin tag

<400>  117

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  118

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  119

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep tag

<400>  120

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag II

<400>  121

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  122
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  122

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  123

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  124
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  124

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  125
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Hinge

<400>  125

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  126
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Hinge coding sequence

<400>  126
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag      360

gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaagatg                                       690


<210>  127
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgD Hinge

<400>  127

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  128
<211>  847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgD Hinge coding sequence

<400>  128
aggtggcccg aaagtcccaa ggcccaggca tctagtgttc ctactgcaca gccccaggca       60

gaaggcagcc tagccaaagc tactactgca cctgccacta cgcgcaatac tggccgtggc      120

ggggaggaga agaaaaagga gaaagagaaa gaagaacagg aagagaggga gaccaagacc      180

cctgaatgtc catcccatac ccagccgctg ggcgtctatc tcttgactcc cgcagtacag      240

gacttgtggc ttagagataa ggccaccttt acatgtttcg tcgtgggctc tgacctgaag      300

gatgcccatt tgacttggga ggttgccgga aaggtaccca cagggggggt tgaggaaggg      360

ttgctggagc gccattccaa tggctctcag agccagcact caagactcac ccttccgaga      420

tccctgtgga acgccgggac ctctgtcaca tgtactctaa atcatcctag cctgccccca      480

cagcgtctga tggcccttag agagccagcc gcccaggcac cagttaagct tagcctgaat      540

ctgctcgcca gtagtgatcc cccagaggcc gccagctggc tcttatgcga agtgtccggc      600

tttagcccgc ccaacatctt gctcatgtgg ctggaggacc agcgagaagt gaacaccagc      660

ggcttcgctc cagcccggcc cccaccccag ccgggttcta ccacattctg ggcctggagt      720

gtcttaaggg tcccagcacc acctagcccc cagccagcca catacacctg tgttgtgtcc      780

catgaagata gcaggaccct gctaaatgct tctaggagtc tggaggtttc ctacgtgact      840

gaccatt                                                                847


<210>  129
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 linker

<400>  129

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  130
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Short spacer

<400>  130
aatctaagta cggaccgccc tgcccccctt gccct                                  35


<210>  131
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intermediate spacer

<400>  131

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  132
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge region, CH2 region, and CH3 region

<400>  132

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  133
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain encoding sequence

<400>  133
atgttctggg tgctggtggt ggtgggcggg gtgctggcct gctacagcct gctggtgaca       60

gtggccttca tcatcttttg g                                                 81


<210>  134
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain encoding sequence

<400>  134
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc       60

gtggccttca tcatcttttg g                                                 81


<210>  135
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain encoding sequence

<400>  135
atgttttggg tgctggtggt ggtgggcggc gtgctggcgt gctatagcct gctggtgacc       60

gtggcgttta ttattttttg g                                                 81


<210>  136
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain encoding sequence

<400>  136
ttttgggtgc tggtggtggt gggcggcgtg ctggcgtgct atagcctgct ggtgaccgtg       60

gcgtttatta ttttt                                                        75


<210>  137
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  137

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25          


<210>  138
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  138

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25      


<210>  139
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3z encoding sequence

<400>  139
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg       60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc      120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc ccaagg                                336


<210>  140
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3z encoding sequence

<400>  140
cgcgtgaaat ttagccgcag cgcggatgcg ccggcgtatc agcagggcca gaaccagctg       60

tataacgaac tgaacctggg ccgccgcgaa gaatatgatg tgctggataa acgccgcggc      120

cgcgatccgg aaatgggcgg caaaccgcgc cgcaaaaacc cgcaggaagg cctgtataac      180

gaactgcaga aagataaaat ggcggaagcg tatagcgaaa ttggcatgaa aggcgaacgc      240

cgccgcggca aaggccatga tggcctgtat cagggcctga gcaccgcgac caaagatacc      300

tatgatgcgc tgcatatgca ggcgctgccg ccgcgc                                336


<210>  141
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3z encoding sequence

<400>  141
gaactgcgcg tgaaatttag ccgcagcgcg gatgcgccgg cgtatcagca gggccagaac       60

cagctgtata acgaactgaa cctgggccgc cgcgaagaat atgatgtgct ggataaacgc      120

cgcggccgcg atccggaaat gggcggcaaa ccgcgccgca aaaacccgca ggaaggcctg      180

tataacgaac tgcagaaaga taaaatggcg gaagcgtata gcgaaattgg catgaaaggc      240

gaacgccgcc gcggcaaagg ccatgatggc ctgtatcagg gcctgagcac cgcgaccaaa      300

gatacctatg atgcgctgca tatgcaggcg ctgccgccgc gc                         342


<210>  142
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z

<400>  142

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  143
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3z

<400>  143

Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            20                  25                  30          


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        35                  40                  45              


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  144
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB encoding sequence

<400>  144
gtgaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta       60

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga      120

tgtgaactg                                                              129


<210>  145
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB encoding sequence

<400>  145
gtgaaacgcg gccgcaaaaa actgctgtat atttttaaac agccgtttat gcgcccggtg       60

cagaccaccc aggaagaaga tggctgcagc tgccgctttc cggaagaaga agaaggcggc      120

tgcgaactg                                                              129


<210>  146
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB encoding sequence

<400>  146
gtgaaacgcg gccgcaaaaa actgctgtat atttttaaac agccgtttat gcgcccggtg       60

cagaccaccc aggaagaaga tggctgcagc tgccgctttc cggaagaaga agaaggcggc      120

tgc                                                                    123


<210>  147
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB

<400>  147

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40              


<210>  148
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB_CPD

<400>  148

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        35                  40      


<210>  149
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thosea asigna virus 2A (T2A) peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  149

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  150
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Porcine teschovirus-1 2A (P2A) peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  150

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  151
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Equine rhinitis A virus (ERAV) 2A (E2A) peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  151

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  152
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Foot-and-mouth disease virus 2A (F2A) peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  (GlySerGly) residues can be added to the 5' end of the peptide to
       improve cleavage efficiency

<400>  152

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  153
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of T2A

<400>  153

Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  154
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of T2A

<400>  154

Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  155
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFRt

<400>  155

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  156
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR

<400>  156

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser 
305                 310         


<210>  157
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM_EGFR

<400>  157

Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
1               5                   10                  15      


Leu Gly Ile Gly Leu Phe Met 
            20              


<210>  158
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7 scFv coding sequence

<400>  158
atgctgctgc tcgtgaccag cctgctgctg tgcgaactgc cccaccctgc ctttctgctg       60

atcccccaag tacaacttca acaaagtgga gccgaactgg taaaacccgg agcgtctgtg      120

aagattagtt gcaaggcatc cggttacgcc ttctcaaatt attggatgaa ctgggtaaag      180

cagcggcccg gaaagggtct cgagtggatt gggcaaatca acccagggga cggggatacg      240

aactacaacg gtaagttcaa aggcaaggct acgttgacgg ctgataagag ctcaagcacc      300

gcttacatgc agttgtcttc tttgacaagt gaggatagtg ccgtttactt ctgcgcccga      360

gaggaccgag attattttga ttattggggc cagggaacaa ctctcaccgt cagctccgga      420

ggcggaggat ctggcggagg gggctctgga ggaggaggat ctgatattca gatgacccaa      480

actacgagtt ccctgtctgc cagccttggc gaccgggtca caattagttg cagggcttct      540

caggatatca actactattt gaactggtac cagcagaaac ctgatgggac ggtcaaactt      600

ctcatctact attcatccag actgcacagt ggcgtaccgt ctagattctc aggaagcggc      660

agtggtacgg attttagtct taccattagt aatctggaac aggaggacat cgccacgtat      720

ttttgccagc aggatgacgc actgccctat accttcggcg gaggcactaa gttggagata      780

aaa                                                                    783


<210>  159
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv coding sequence

<400>  159
gacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc       60

atcagctgcc gggccagcca ggacatcagc aagtacctga actggtatca gcagaagccc      120

gacggcaccg tcaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag      240

gaagatatcg ccacctactt ttgccagcag ggcaacacac tgccctacac ctttggcggc      300

ggaacaaagc tggaaatcac cggcagcacc tccggcagcg gcaagcctgg cagcggcgag      360

ggcagcacca agggcgaggt gaagctgcag gaaagcggcc ctggcctggt ggcccccagc      420

cagagcctga gcgtgacctg caccgtgagc ggcgtgagcc tgcccgacta cggcgtgagc      480

tggatccggc agccccccag gaagggcctg gaatggctgg gcgtgatctg gggcagcgag      540

accacctact acaacagcgc cctgaagagc cggctgacca tcatcaagga caacagcaag      600

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      660

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      720

gtgaccgtga gcagc                                                       735


<210>  160
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  161
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     


<210>  162
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  163
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H7 (IMGT)

<400>  163

Gln Asp Ile Asn Tyr Tyr 
1               5       


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 (IMGT)

<400>  164

Gly Tyr Ala Phe Ser Asn Tyr Trp 
1               5               


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7 (IMGT)

<400>  165

Ile Asn Pro Gly Asp Gly Asp Thr 
1               5               


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H7 (Kabat and Chothia)

<400>  166

Tyr Ser Ser Arg Leu His Ser 
1               5           


<210>  167
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 (Kabat)

<400>  167

Asn Tyr Trp Met Asn 
1               5   


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7 (Kabat)

<400>  168

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  169
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H7 (Kabat and Chothia)

<400>  169

Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5               


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 (Chothia)

<400>  170

Gly Tyr Ala Phe Ser Asn Tyr 
1               5           


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7 (Chothia)

<400>  171

Asn Pro Gly Asp Gly Asp 
1               5       


<210>  172
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-type lectin

<400>  172

His Lys Asp Ser Cys Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln 
1               5                   10                  15      


Glu Ser Lys Met Ala Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile 
            20                  25                  30          


Asn Asn Lys Asn Ala Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr 
        35                  40                  45              


Asp Tyr Trp Leu Gly Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met 
    50                  55                  60                  


Arg Val Asp Asn Ile Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala 
65                  70                  75                  80  


Pro Asp Leu Asn Asn Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val 
                85                  90                  95      


Gln Tyr Tyr His Cys Thr Tyr Lys Lys Arg Met Ile Cys 
            100                 105                 


<210>  173
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker coding sequence

<400>  173
ggaggaggag gcagcggcgg aggaggctcc ggaggcggcg gctctggcgg cggcggcagc       60


<210>  174
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv

<400>  174

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  175
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  176
<211>  3612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7-long-41bb-3z-T-CD19t Top Strand

<400>  176
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaagtacaa cttcaacaaa gtggagccga actggtaaaa      660

cccggagcgt ctgtgaagat tagttgcaag gcatccggtt acgccttctc aaattattgg      720

atgaactggg taaagcagcg gcccggaaag ggtctcgagt ggattgggca aatcaaccca      780

ggggacgggg atacgaacta caacggtaag ttcaaaggca aggctacgtt gacggctgat      840

aagagctcaa gcaccgctta catgcagttg tcttctttga caagtgagga tagtgccgtt      900

tacttctgcg cccgagagga ccgagattat tttgattatt ggggccaggg aacaactctc      960

accgtcagct ccggaggcgg aggatctggc ggagggggct ctggaggagg aggatctgat     1020

attcagatga cccaaactac gagttccctg tctgccagcc ttggcgaccg ggtcacaatt     1080

agttgcaggg cttctcagga tatcaactac tatttgaact ggtaccagca gaaacctgat     1140

gggacggtca aacttctcat ctactattca tccagactgc acagtggcgt accgtctaga     1200

ttctcaggaa gcggcagtgg tacggatttt agtcttacca ttagtaatct ggaacaggag     1260

gacatcgcca cgtatttttg ccagcaggat gacgcactgc cctatacctt cggcggaggc     1320

actaagttgg agataaaaga gtctaagtac ggaccgcctt gcccaccgtg cccagcacca     1380

cctgtggcag gaccgtcagt cttcctcttc ccaccaaaac ccaaggacac cctgatgatc     1440

agccggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccaggaaga tcccgaggtc     1500

cagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag     1560

gaacagttcc aaagcaccta ccgggtggtg tctgtgctga ccgtgctgca ccaggactgg     1620

ctgaacggca aagaatacaa gtgcaaggtg tccaacaagg gcctgcccag cagcatcgaa     1680

aagaccatca gcaaggccaa gggccagcct cgcgagcccc aggtgtacac cctgcctccc     1740

tcccaggaag agatgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac     1800

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ctgagaacaa ctacaagacc     1860

acccctcccg tgctggacag cgacggcagc ttcttcctgt acagccggct gaccgtggac     1920

aagagccggt ggcaggaagg caacgtcttt agctgcagcg tgatgcacga ggccctgcac     1980

aaccactaca cccagaagag cctgagcctg tccctgggca agatgttctg ggtgctggtg     2040

gtggtgggcg gggtgctggc ctgctacagc ctgctggtga cagtggcctt catcatcttt     2100

tgggtgaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     2160

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     2220

ggatgtgaac tgcgggtgaa gttcagcaga agcgccgacg cccctgccta ccagcagggc     2280

cagaatcagc tgtacaacga gctgaacctg ggcagaaggg aagagtacga cgtcctggat     2340

aagcggagag gccgggaccc tgagatgggc ggcaagcctc ggcggaagaa cccccaggaa     2400

ggcctgtata acgaactgca gaaagacaag atggccgagg cctacagcga gatcggcatg     2460

aagggcgagc ggaggcgggg caagggccac gacggcctgt atcagggcct gtccaccgcc     2520

accaaggata cctacgacgc cctgcacatg caggccctgc ccccaaggct cgagggcggc     2580

ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc aggccctagg     2640

atgccacctc caagactcct cttcttcctc ctcttcctga caccaatgga agtcaggcct     2700

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgttaca gtgcctcaag     2760

ggaacctcag atggacccac tcagcagctg acctggtctc gggagtctcc gcttaaaccc     2820

ttcctgaaac tcagccttgg actgccaggt ctgggaatcc acatgaggcc actggctatc     2880

tggctgttca tcttcaacgt ctctcaacag atgggaggct tctacctgtg tcagcctgga     2940

ccaccttctg agaaggcatg gcagcctggt tggacagtca atgtggaggg ttctggtgag     3000

ctgttccggt ggaatgtttc ggacctaggt ggactgggat gtggtctgaa gaacaggtcc     3060

tcagagggac ctagctctcc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc     3120

aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg     3180

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt     3240

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag     3300

gggcctaagt cattgctgag cctagagctg aaggacgatc gccctgccag agatatgtgg     3360

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat     3420

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta     3480

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg     3540

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg     3600

aggaaaagat ga                                                         3612


<210>  177
<211>  2964
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1H7-sh-41bb-3z-T-CD19t Top Strand

<400>  177
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacggctag ccaccatgct gctgctcgtg accagcctgc tgctgtgcga actgccccac      600

cctgcctttc tgctgatccc ccaagtacaa cttcaacaaa gtggagccga actggtaaaa      660

cccggagcgt ctgtgaagat tagttgcaag gcatccggtt acgccttctc aaattattgg      720

atgaactggg taaagcagcg gcccggaaag ggtctcgagt ggattgggca aatcaaccca      780

ggggacgggg atacgaacta caacggtaag ttcaaaggca aggctacgtt gacggctgat      840

aagagctcaa gcaccgctta catgcagttg tcttctttga caagtgagga tagtgccgtt      900

tacttctgcg cccgagagga ccgagattat tttgattatt ggggccaggg aacaactctc      960

accgtcagct ccggaggcgg aggatctggc ggagggggct ctggaggagg aggatctgat     1020

attcagatga cccaaactac gagttccctg tctgccagcc ttggcgaccg ggtcacaatt     1080

agttgcaggg cttctcagga tatcaactac tatttgaact ggtaccagca gaaacctgat     1140

gggacggtca aacttctcat ctactattca tccagactgc acagtggcgt accgtctaga     1200

ttctcaggaa gcggcagtgg tacggatttt agtcttacca ttagtaatct ggaacaggag     1260

gacatcgcca cgtatttttg ccagcaggat gacgcactgc cctatacctt cggcggaggc     1320

actaagttgg agataaaaga gtctaagtac ggaccgccct gccccccttg ccctatgttc     1380

tgggtgctgg tggtggtcgg aggcgtgctg gcctgctaca gcctgctggt caccgtggcc     1440

ttcatcatct tttgggtgaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1500

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1560

gaagaagaag gaggatgtga actgcgggtg aagttcagca gaagcgccga cgcccctgcc     1620

taccagcagg gccagaatca gctgtacaac gagctgaacc tgggcagaag ggaagagtac     1680

gacgtcctgg ataagcggag aggccgggac cctgagatgg gcggcaagcc tcggcggaag     1740

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1800

gagatcggca tgaagggcga gcggaggcgg ggcaagggcc acgacggcct gtatcagggc     1860

ctgtccaccg ccaccaagga tacctacgac gccctgcaca tgcaggccct gcccccaagg     1920

ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat     1980

ccaggcccta ggatgccacc tccaagactc ctcttcttcc tcctcttcct gacaccaatg     2040

gaagtcaggc ctgaggaacc tctagtggtg aaggtggaag agggagataa cgctgtgtta     2100

cagtgcctca agggaacctc agatggaccc actcagcagc tgacctggtc tcgggagtct     2160

ccgcttaaac ccttcctgaa actcagcctt ggactgccag gtctgggaat ccacatgagg     2220

ccactggcta tctggctgtt catcttcaac gtctctcaac agatgggagg cttctacctg     2280

tgtcagcctg gaccaccttc tgagaaggca tggcagcctg gttggacagt caatgtggag     2340

ggttctggtg agctgttccg gtggaatgtt tcggacctag gtggactggg atgtggtctg     2400

aagaacaggt cctcagaggg acctagctct ccttccggga agctcatgag ccccaagctg     2460

tatgtgtggg ccaaagaccg ccctgagatc tgggagggag agcctccgtg tgtcccaccg     2520

agggacagcc tgaaccagag cctcagccag gacctcacca tggcccctgg ctccacactc     2580

tggctgtcct gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat     2640

gtgcacccca aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgccctgcc     2700

agagatatgt gggtaatgga gacgggtctg ttgttgcccc gggccacagc tcaagacgct     2760

ggaaagtatt attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct     2820

cggccagtac tatggcactg gctgctgagg actggtggct ggaaggtctc agctgtgact     2880

ttggcttatc tgatcttctg cctgtgttcc cttgtgggca ttcttcatct tcaaagagcc     2940

ctggtcctga ggaggaaaag atga                                            2964


<210>  178
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  178

Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser 
1               5                   10                  15      


Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr 
            20                  25                  30          


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
        35                  40                  45              


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
    50                  55                  60                  


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
65                  70                  75                  80  


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
                85                  90                  95      


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
            100                 105                 110         


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
        115                 120                 125             


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
    130                 135                 140                 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
145                 150                 155                 160 


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
                165                 170                 175     


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185     


