                         SEQUENCE LISTING

<110>  The United States of America as Represented by the 
       Secretary of the Navy
 
<120>  Antigen Binding Proteins to Class 5  ETEC Adhesins

<130>  NC110768PCT

<150>  US 63/004,002
<151>  2020-04-02

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  361
<212>  PRT
<213>  Escherichia coli

<400>  1

Ala Asp Lys Asn Pro Gly Ser Glu Asn Met Thr Asn Thr Ile Gly Pro 
1               5                   10                  15      


His Asp Arg Gly Gly Ser Ser Pro Ile Tyr Asn Ile Leu Asn Ser Tyr 
            20                  25                  30          


Leu Thr Ala Tyr Asn Gly Ser His His Leu Tyr Asp Arg Met Ser Phe 
        35                  40                  45              


Leu Cys Leu Ser Ser Gln Asn Thr Leu Asn Gly Ala Cys Pro Ser Ser 
    50                  55                  60                  


Asp Ala Pro Gly Thr Ala Thr Ile Asp Gly Glu Thr Asn Ile Thr Leu 
65                  70                  75                  80  


Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg Glu Leu Gln Ile Lys 
                85                  90                  95      


Gly Tyr Lys Gln Phe Leu Phe Lys Asn Ala Asn Cys Pro Ser Lys Leu 
            100                 105                 110         


Ala Leu Asn Ser Ser His Phe Gln Cys Asn Arg Glu Gln Ala Ser Gly 
        115                 120                 125             


Ala Thr Leu Ser Leu Tyr Ile Pro Ala Gly Glu Leu Asn Lys Leu Pro 
    130                 135                 140                 


Phe Gly Gly Val Trp Asn Ala Val Leu Lys Leu Asn Val Lys Arg Arg 
145                 150                 155                 160 


Tyr Asp Thr Thr Tyr Gly Thr Tyr Thr Ile Asn Ile Thr Val Asn Leu 
                165                 170                 175     


Thr Asp Lys Gly Asn Ile Gln Ile Trp Leu Pro Gln Phe Lys Ser Asn 
            180                 185                 190         


Ala Arg Val Asp Leu Asn Leu Arg Pro Thr Gly Gly Gly Thr Tyr Ile 
        195                 200                 205             


Gly Arg Asn Ser Val Asp Met Cys Phe Tyr Asp Gly Tyr Ser Thr Asn 
    210                 215                 220                 


Ser Ser Ser Leu Glu Ile Arg Phe Gln Asp Asp Asn Ser Lys Ser Asp 
225                 230                 235                 240 


Gly Lys Phe Tyr Leu Lys Lys Ile Asn Asp Asp Ser Lys Glu Leu Val 
                245                 250                 255     


Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys Asn Leu Thr Pro Thr Asn 
            260                 265                 270         


Gly Gln Ala Leu Asn Ile Asn Thr Ala Ser Leu Glu Thr Asn Trp Asn 
        275                 280                 285             


Arg Ile Thr Ala Val Thr Met Pro Glu Ile Ser Val Pro Val Leu Cys 
    290                 295                 300                 


Trp Pro Gly Arg Leu Gln Leu Asp Ala Lys Val Lys Asn Pro Glu Ala 
305                 310                 315                 320 


Gly Gln Tyr Met Gly Asn Ile Lys Ile Thr Phe Thr Pro Ser Ser Gln 
                325                 330                 335     


Thr Leu Asp Asn Lys Gln Val Glu Lys Asn Ile Thr Val Thr Ala Ser 
            340                 345                 350         


Val Asp Pro Val Ile Asp Leu Leu Gln 
        355                 360     


<210>  2
<211>  368
<212>  PRT
<213>  Escherichia coli

<400>  2

Gly Arg Tyr Pro Glu Thr Thr Val Gly Asn Leu Thr Lys Ser Phe Gln 
1               5                   10                  15      


Ala Pro Arg Gln Asp Arg Ser Val Gln Ser Pro Ile Tyr Asn Ile Phe 
            20                  25                  30          


Thr Asn His Val Ala Gly Tyr Ser Leu Ser His Asn Leu Tyr Asp Arg 
        35                  40                  45              


Ile Val Phe Leu Cys Thr Ser Ser Ser Asn Pro Val Asn Gly Ala Cys 
    50                  55                  60                  


Pro Thr Leu Gly Thr Ser Gly Val Gln Tyr Gly Thr Thr Thr Ile Thr 
65                  70                  75                  80  


Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg Asn Ile Asn Leu 
                85                  90                  95      


Ala Gly Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp Thr Ser 
            100                 105                 110         


Asn Leu Met Val Leu Asn Ser Lys Ser Trp Ser Cys Gly His Tyr Gly 
        115                 120                 125             


Asn Ala Asn Gly Thr Leu Leu Asn Leu Tyr Ile Pro Ala Gly Glu Ile 
    130                 135                 140                 


Asn Lys Leu Pro Phe Gly Gly Ile Trp Glu Ala Thr Leu Ile Leu Arg 
145                 150                 155                 160 


Leu Ser Arg Tyr Gly Glu Val Ser Ser Thr His Tyr Gly Asn Tyr Thr 
                165                 170                 175     


Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln Val Trp 
            180                 185                 190         


Leu Pro Gly Phe His Ser Asn Pro Arg Val Asp Leu Asn Leu His Pro 
        195                 200                 205             


Ile Gly Asn Tyr Lys Tyr Ser Gly Ser Asn Ser Leu Asp Met Cys Phe 
    210                 215                 220                 


Tyr Asp Gly Tyr Ser Thr Asn Ser Asp Ser Met Val Ile Lys Phe Gln 
225                 230                 235                 240 


Asp Asp Asn Pro Thr Tyr Ser Ser Glu Tyr Asn Leu Tyr Lys Ile Gly 
                245                 250                 255     


Gly Thr Glu Lys Leu Pro Tyr Ala Val Ser Leu Leu Met Gly Glu Lys 
            260                 265                 270         


Ile Phe Tyr Pro Val Asn Gly Gln Ser Phe Thr Ile Asn Asp Ser Ser 
        275                 280                 285             


Val Leu Glu Thr Asn Trp Asn Arg Val Thr Ala Val Ala Met Pro Glu 
    290                 295                 300                 


Val Asn Val Pro Val Leu Cys Trp Pro Ala Arg Leu Leu Leu Asn Ala 
305                 310                 315                 320 


Asp Val Asn Ala Pro Asp Ala Gly Gln Tyr Ser Gly Gln Ile Tyr Ile 
                325                 330                 335     


Thr Phe Thr Pro Ser Val Glu Asn Leu Asp Asn Lys Gln Val Glu Lys 
            340                 345                 350         


Asn Ile Thr Val Arg Ala Ser Val Asp Pro Lys Leu Asp Leu Leu Gln 
        355                 360                 365             


<210>  3
<211>  369
<212>  PRT
<213>  Escherichia coli

<400>  3

Gln Ser Trp His Thr Asn Val Glu Ala Gly Ser Ile Asn Lys Thr Glu 
1               5                   10                  15      


Ser Ile Gly Pro Ile Asp Arg Ser Ala Ala Ala Ser Tyr Pro Ala His 
            20                  25                  30          


Tyr Ile Phe His Glu His Val Ala Gly Tyr Asn Lys Asp His Ser Leu 
        35                  40                  45              


Phe Asp Arg Met Thr Phe Leu Cys Met Ser Ser Thr Asp Ala Ser Lys 
    50                  55                  60                  


Gly Ala Cys Pro Thr Gly Glu Asn Ser Lys Ser Ser Gln Gly Glu Thr 
65                  70                  75                  80  


Asn Ile Lys Leu Ile Phe Thr Glu Lys Lys Ser Leu Ala Arg Lys Thr 
                85                  90                  95      


Leu Asn Leu Lys Gly Tyr Lys Arg Phe Leu Tyr Glu Ser Asp Arg Cys 
            100                 105                 110         


Ile His Tyr Val Asp Lys Met Asn Leu Asn Ser His Thr Val Lys Cys 
        115                 120                 125             


Val Gly Ser Phe Thr Arg Gly Val Asp Phe Thr Leu Tyr Ile Pro Gln 
    130                 135                 140                 


Gly Glu Ile Asp Gly Leu Leu Thr Gly Gly Ile Trp Glu Ala Thr Leu 
145                 150                 155                 160 


Glu Leu Arg Val Lys Arg His Tyr Asp Tyr Asn His Gly Thr Tyr Lys 
                165                 170                 175     


Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln Val Trp 
            180                 185                 190         


Thr Pro Lys Phe His Ser Asp Pro Arg Ile Asp Leu Asn Leu Arg Pro 
        195                 200                 205             


Glu Gly Asn Gly Lys Tyr Ser Gly Ser Asn Val Leu Glu Met Cys Leu 
    210                 215                 220                 


Tyr Asp Gly Tyr Ser Thr His Ser Gln Ser Ile Glu Met Arg Phe Gln 
225                 230                 235                 240 


Asp Asp Ser Gln Thr Gly Asn Asn Glu Tyr Asn Leu Ile Lys Thr Gly 
                245                 250                 255     


Glu Pro Leu Lys Lys Leu Pro Tyr Lys Leu Ser Leu Leu Leu Gly Gly 
            260                 265                 270         


Arg Glu Phe Tyr Pro Asn Asn Gly Glu Ala Phe Thr Ile Asn Asp Thr 
        275                 280                 285             


Ser Ser Leu Phe Ile Asn Trp Asn Arg Ile Lys Ser Val Ser Leu Pro 
    290                 295                 300                 


Gln Ile Ser Ile Pro Val Leu Cys Trp Pro Ala Asn Leu Thr Phe Met 
305                 310                 315                 320 


Ser Glu Leu Asn Asn Pro Glu Ala Gly Glu Tyr Ser Gly Ile Leu Asn 
                325                 330                 335     


Val Thr Phe Thr Pro Ser Ser Ser Ser Leu Asp Asn Lys Gln Ala Glu 
            340                 345                 350         


Lys Asn Ile Thr Val Thr Ala Ser Val Asp Pro Thr Ile Asp Leu Met 
        355                 360                 365             


Gln 
    


<210>  4
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dsc19CfaE6xHis (H10407)

<400>  4
atgaataaaa ttttatttat ttttacattg tttttttctt cagggttttt tacatttgcc       60

gtatcggcag ataaaaatcc cggaagtgaa aacatgacta atactattgg tccccatgac      120

agggggggat cttcccccat atataatatc ttaaattcct atcttacagc atacaatgga      180

agccatcatc tgtatgatag gatgagtttt ttatgtttgt cttctcaaaa tacactgaat      240

ggagcatgcc caagcagtga tgcccctggc actgctacaa ttgatggcga aacaaatata      300

acattacaat ttacggaaaa aagaagtcta attaaaagag aactgcaaat taaaggctat      360

aaacaatttt tgttcaaaaa tgctaattgc ccatctaaac tagcacttaa ctcatctcat      420

tttcaatgta atagagaaca agcttcaggt gctactttat cgttatacat accagctggt      480

gaattaaata aattaccttt tgggggggtc tggaatgccg ttctgaagct aaatgtaaaa      540

agacgatatg atacaaccta tgggacttac actataaaca tcacagttaa tttaactgat      600

aagggaaata ttcagatatg gttaccacag ttcaaaagta acgctcgtgt cgatcttaac      660

ttgcgtccaa ctggtggtgg tacatatatc ggaagaaatt ctgttgatat gtgcttttat      720

gatggatata gtactaacag cagctcttta gagataagat ttcaggatga taattctaaa      780

tctgatggaa aattttatct aaagaaaata aatgatgact ccaaagaact tgtatacact      840

ttgtcacttc tcctggcagg taaaaattta acaccaacaa atggacaggc attaaatatt      900

aacactgctt ctctggaaac aaactggaat agaattacag ctgtcaccat gccagaaatc      960

agtgttccgg tgttgtgttg gcctggacgt ttgcaattgg atgcaaaagt gaaaaatccc     1020

gaggctggac aatatatggg gaatattaaa attactttca caccaagtag tcaaacactc     1080

gacaataaac aagtagagaa aaatattact gtaacagcta gtgttgatcc tgtgattgat     1140

cttttgcaac tcgagcacca ccaccaccac cactga                               1176


<210>  5
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dsc19CfaE6xHis (H10407)

<400>  5

Met Asn Lys Ile Leu Phe Ile Phe Thr Leu Phe Phe Ser Ser Gly Phe 
1               5                   10                  15      


Phe Thr Phe Ala Val Ser Ala Asp Lys Asn Pro Gly Ser Glu Asn Met 
            20                  25                  30          


Thr Asn Thr Ile Gly Pro His Asp Arg Gly Gly Ser Ser Pro Ile Tyr 
        35                  40                  45              


Asn Ile Leu Asn Ser Tyr Leu Thr Ala Tyr Asn Gly Ser His His Leu 
    50                  55                  60                  


Tyr Asp Arg Met Ser Phe Leu Cys Leu Ser Ser Gln Asn Thr Leu Asn 
65                  70                  75                  80  


Gly Ala Cys Pro Ser Ser Asp Ala Pro Gly Thr Ala Thr Ile Asp Gly 
                85                  90                  95      


Glu Thr Asn Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys 
            100                 105                 110         


Arg Glu Leu Gln Ile Lys Gly Tyr Lys Gln Phe Leu Phe Lys Asn Ala 
        115                 120                 125             


Asn Cys Pro Ser Lys Leu Ala Leu Asn Ser Ser His Phe Gln Cys Asn 
    130                 135                 140                 


Arg Glu Gln Ala Ser Gly Ala Thr Leu Ser Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Leu Asn Lys Leu Pro Phe Gly Gly Val Trp Asn Ala Val Leu Lys 
                165                 170                 175     


Leu Asn Val Lys Arg Arg Tyr Asp Thr Thr Tyr Gly Thr Tyr Thr Ile 
            180                 185                 190         


Asn Ile Thr Val Asn Leu Thr Asp Lys Gly Asn Ile Gln Ile Trp Leu 
        195                 200                 205             


Pro Gln Phe Lys Ser Asn Ala Arg Val Asp Leu Asn Leu Arg Pro Thr 
    210                 215                 220                 


Gly Gly Gly Thr Tyr Ile Gly Arg Asn Ser Val Asp Met Cys Phe Tyr 
225                 230                 235                 240 


Asp Gly Tyr Ser Thr Asn Ser Ser Ser Leu Glu Ile Arg Phe Gln Asp 
                245                 250                 255     


Asp Asn Ser Lys Ser Asp Gly Lys Phe Tyr Leu Lys Lys Ile Asn Asp 
            260                 265                 270         


Asp Ser Lys Glu Leu Val Tyr Thr Leu Ser Leu Leu Leu Ala Gly Lys 
        275                 280                 285             


Asn Leu Thr Pro Thr Asn Gly Gln Ala Leu Asn Ile Asn Thr Ala Ser 
    290                 295                 300                 


Leu Glu Thr Asn Trp Asn Arg Ile Thr Ala Val Thr Met Pro Glu Ile 
305                 310                 315                 320 


Ser Val Pro Val Leu Cys Trp Pro Gly Arg Leu Gln Leu Asp Ala Lys 
                325                 330                 335     


Val Lys Asn Pro Glu Ala Gly Gln Tyr Met Gly Asn Ile Lys Ile Thr 
            340                 345                 350         


Phe Thr Pro Ser Ser Gln Thr Leu Asp Asn Lys Gln Val Glu Lys Asn 
        355                 360                 365             


Ile Thr Val Thr Ala Ser Val Asp Pro Val Ile Asp Leu Leu Gln Leu 
    370                 375                 380                 


Glu His His His His His His 
385                 390     


<210>  6
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dsc19CsbD6xHis (WS6788A)

<400>  6
atgaaaaaga tatttatttt tttgtctatc atattttctg cggtggtcag tgccgggcga       60

tacccggaaa ctacagtagg taatctgacg aagagttttc aagcccctcg tcaggataga      120

agcgtacaat caccaatata taacatcttt acgaatcatg tggctggata tagtttgagt      180

cataacttat atgacaggat tgttttttta tgtacatcct cgtcgaatcc ggttaatggt      240

gcttgcccaa cccttggaac atctggagtt caatacggta ctacaaccat aaccttgcag      300

tttacagaaa aaagaagtct gataaaaaga aatattaatc ttgcaggtaa taagaaacca      360

atatgggaga atcagagttg cgacactagc aatctaatgg tgttgaattc gaagtcttgg      420

tcctgtgggc attacggaaa tgctaacgga acacttctaa atctgtatat ccctgcagga      480

gaaatcaaca aattgccttt tggagggata tgggaggcaa ctctgatctt acgcttatca      540

agatatggcg aagtcagtag cacccattac ggcaattata ccgtaaatat tacggttgat      600

ttaactgata aaggtaatat tcaggtatgg cttccagggt ttcacagcaa cccgcgtgta      660

gacctgaatc tgcaccctat cggtaattat aaatatagtg gtagtaattc actcgacatg      720

tgtttctatg atggatatag tacaaacagt gatagcatgg taataaagtt ccaggatgat      780

aatcctacct attcatctga atataatctt tataagatag ggggcactga aaaattacca      840

tatgctgttt cactgcttat gggagaaaaa atattttatc cagtgaatgg tcaatcattt      900

actatcaatg acagtagtgt actcgaaaca aactggaatc gagtaaccgc agttgctatg      960

ccggaagtta atgttccagt attatgctgg ccagcaagat tgctattaaa tgctgatgta     1020

aatgctcccg atgcaggaca gtattcagga cagatatata taacatttac acccagtgtc     1080

gaaaatttag acaataaaca agtcgaaaaa aatattactg tgagggcaag tgttgaccct     1140

aaacttgatc ttctgcaact cgagcaccac caccaccacc actga                     1185


<210>  7
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dsc19CsbD6xHis (WS6788A)

<400>  7

Met Lys Lys Ile Phe Ile Phe Leu Ser Ile Ile Phe Ser Ala Val Val 
1               5                   10                  15      


Ser Ala Gly Arg Tyr Pro Glu Thr Thr Val Gly Asn Leu Thr Lys Ser 
            20                  25                  30          


Phe Gln Ala Pro Arg Gln Asp Arg Ser Val Gln Ser Pro Ile Tyr Asn 
        35                  40                  45              


Ile Phe Thr Asn His Val Ala Gly Tyr Ser Leu Ser His Asn Leu Tyr 
    50                  55                  60                  


Asp Arg Ile Val Phe Leu Cys Thr Ser Ser Ser Asn Pro Val Asn Gly 
65                  70                  75                  80  


Ala Cys Pro Thr Leu Gly Thr Ser Gly Val Gln Tyr Gly Thr Thr Thr 
                85                  90                  95      


Ile Thr Leu Gln Phe Thr Glu Lys Arg Ser Leu Ile Lys Arg Asn Ile 
            100                 105                 110         


Asn Leu Ala Gly Asn Lys Lys Pro Ile Trp Glu Asn Gln Ser Cys Asp 
        115                 120                 125             


Thr Ser Asn Leu Met Val Leu Asn Ser Lys Ser Trp Ser Cys Gly His 
    130                 135                 140                 


Tyr Gly Asn Ala Asn Gly Thr Leu Leu Asn Leu Tyr Ile Pro Ala Gly 
145                 150                 155                 160 


Glu Ile Asn Lys Leu Pro Phe Gly Gly Ile Trp Glu Ala Thr Leu Ile 
                165                 170                 175     


Leu Arg Leu Ser Arg Tyr Gly Glu Val Ser Ser Thr His Tyr Gly Asn 
            180                 185                 190         


Tyr Thr Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln 
        195                 200                 205             


Val Trp Leu Pro Gly Phe His Ser Asn Pro Arg Val Asp Leu Asn Leu 
    210                 215                 220                 


His Pro Ile Gly Asn Tyr Lys Tyr Ser Gly Ser Asn Ser Leu Asp Met 
225                 230                 235                 240 


Cys Phe Tyr Asp Gly Tyr Ser Thr Asn Ser Asp Ser Met Val Ile Lys 
                245                 250                 255     


Phe Gln Asp Asp Asn Pro Thr Tyr Ser Ser Glu Tyr Asn Leu Tyr Lys 
            260                 265                 270         


Ile Gly Gly Thr Glu Lys Leu Pro Tyr Ala Val Ser Leu Leu Met Gly 
        275                 280                 285             


Glu Lys Ile Phe Tyr Pro Val Asn Gly Gln Ser Phe Thr Ile Asn Asp 
    290                 295                 300                 


Ser Ser Val Leu Glu Thr Asn Trp Asn Arg Val Thr Ala Val Ala Met 
305                 310                 315                 320 


Pro Glu Val Asn Val Pro Val Leu Cys Trp Pro Ala Arg Leu Leu Leu 
                325                 330                 335     


Asn Ala Asp Val Asn Ala Pro Asp Ala Gly Gln Tyr Ser Gly Gln Ile 
            340                 345                 350         


Tyr Ile Thr Phe Thr Pro Ser Val Glu Asn Leu Asp Asn Lys Gln Val 
        355                 360                 365             


Glu Lys Asn Ile Thr Val Arg Ala Ser Val Asp Pro Lys Leu Asp Leu 
    370                 375                 380                 


Leu Gln Leu Glu His His His His His His 
385                 390                 


<210>  8
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dsc19CotD6xHis (C91f)

<400>  8
atgaaaaaag tgatttttgt tttatccatg tttctatgtt ctcaggttta cgggcaatca       60

tggcatacga acgtagaggc tggttcaata aataaaacag agtcgatagg ccccatagac      120

cgaagtgctg ctgcatcgta tcctgctcat tatatatttc atgaacatgt tgctggttac      180

aataaagatc actctctttt tgacaggatg acgtttttat gtatgtcatc aacagatgca      240

tctaaaggtg catgtccgac aggagaaaac tccaaatcct ctcaagggga gactaatatt      300

aagctaatat ttactgaaaa gaaaagtctg gccagaaaaa cattaaactt aaaaggatat      360

aagagatttt tatatgaatc agatagatgc attcattatg tcgataaaat gaatctcaat      420

tctcatactg ttaaatgtgt aggttcattc acaagaggag tagatttcac tttatatatc      480

ccacaaggtg aaattgatgg gcttctaact ggaggtatat gggaggcaac actagagtta      540

cgagtcaaaa ggcattacga ctataatcat ggtacttaca aagttaatat cacagttgat      600

ttgacagaca aaggaaatat tcaggtctgg acaccaaagt ttcatagcga tcctagaatt      660

gatctgaatt tacgtcctga aggtaatggt aaatattctg gtagtaacgt gcttgagatg      720

tgtctctatg atggctatag tacacatagt caaagtatag aaatgaggtt tcaggatgac      780

tcacaaacag gaaataatga atataatctt ataaaaactg gagagccatt aaaaaaattg      840

ccatataaac tttctcttct tttaggagga cgagagtttt atccaaataa tggagaggct      900

tttactatta atgatacttc gtcattgttt ataaactgga atcgtattaa gtctgtatcc      960

ttaccacaga ttagtattcc agtactatgc tggccagcaa acttgacatt tatgtcagag     1020

ctaaataatc cagaagcggg tgagtattca ggaatactta acgtaacatt tactcctagt     1080

agttcaagtc tggacaataa acaagccgag aaaaatatca ctgtaactgc tagcgttgat     1140

ccaactatcg atctgatgca actcgagcac caccaccacc accactga                  1188


<210>  9
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dsc19CotD6xHis (C91f)

<400>  9

Met Lys Lys Val Ile Phe Val Leu Ser Met Phe Leu Cys Ser Gln Val 
1               5                   10                  15      


Tyr Gly Gln Ser Trp His Thr Asn Val Glu Ala Gly Ser Ile Asn Lys 
            20                  25                  30          


Thr Glu Ser Ile Gly Pro Ile Asp Arg Ser Ala Ala Ala Ser Tyr Pro 
        35                  40                  45              


Ala His Tyr Ile Phe His Glu His Val Ala Gly Tyr Asn Lys Asp His 
    50                  55                  60                  


Ser Leu Phe Asp Arg Met Thr Phe Leu Cys Met Ser Ser Thr Asp Ala 
65                  70                  75                  80  


Ser Lys Gly Ala Cys Pro Thr Gly Glu Asn Ser Lys Ser Ser Gln Gly 
                85                  90                  95      


Glu Thr Asn Ile Lys Leu Ile Phe Thr Glu Lys Lys Ser Leu Ala Arg 
            100                 105                 110         


Lys Thr Leu Asn Leu Lys Gly Tyr Lys Arg Phe Leu Tyr Glu Ser Asp 
        115                 120                 125             


Arg Cys Ile His Tyr Val Asp Lys Met Asn Leu Asn Ser His Thr Val 
    130                 135                 140                 


Lys Cys Val Gly Ser Phe Thr Arg Gly Val Asp Phe Thr Leu Tyr Ile 
145                 150                 155                 160 


Pro Gln Gly Glu Ile Asp Gly Leu Leu Thr Gly Gly Ile Trp Glu Ala 
                165                 170                 175     


Thr Leu Glu Leu Arg Val Lys Arg His Tyr Asp Tyr Asn His Gly Thr 
            180                 185                 190         


Tyr Lys Val Asn Ile Thr Val Asp Leu Thr Asp Lys Gly Asn Ile Gln 
        195                 200                 205             


Val Trp Thr Pro Lys Phe His Ser Asp Pro Arg Ile Asp Leu Asn Leu 
    210                 215                 220                 


Arg Pro Glu Gly Asn Gly Lys Tyr Ser Gly Ser Asn Val Leu Glu Met 
225                 230                 235                 240 


Cys Leu Tyr Asp Gly Tyr Ser Thr His Ser Gln Ser Ile Glu Met Arg 
                245                 250                 255     


Phe Gln Asp Asp Ser Gln Thr Gly Asn Asn Glu Tyr Asn Leu Ile Lys 
            260                 265                 270         


Thr Gly Glu Pro Leu Lys Lys Leu Pro Tyr Lys Leu Ser Leu Leu Leu 
        275                 280                 285             


Gly Gly Arg Glu Phe Tyr Pro Asn Asn Gly Glu Ala Phe Thr Ile Asn 
    290                 295                 300                 


Asp Thr Ser Ser Leu Phe Ile Asn Trp Asn Arg Ile Lys Ser Val Ser 
305                 310                 315                 320 


Leu Pro Gln Ile Ser Ile Pro Val Leu Cys Trp Pro Ala Asn Leu Thr 
                325                 330                 335     


Phe Met Ser Glu Leu Asn Asn Pro Glu Ala Gly Glu Tyr Ser Gly Ile 
            340                 345                 350         


Leu Asn Val Thr Phe Thr Pro Ser Ser Ser Ser Leu Asp Asn Lys Gln 
        355                 360                 365             


Ala Glu Lys Asn Ile Thr Val Thr Ala Ser Val Asp Pro Thr Ile Asp 
    370                 375                 380                 


Leu Met Gln Leu Glu His His His His His His 
385                 390                 395 


<210>  10
<211>  420
<212>  DNA
<213>  mouse

<400>  10
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggacagtc aacatatgct      240

gatgacttca agggacgctt tgccttctct ttggaaacct ctgccagcac tgcccatttg      300

cagatcagca acctcaaaaa tgaggacgcg gctacatatt tctgtgcaag aatggagtat      360

ggtaactacg aaaatgcttt ggattactgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  11
<211>  140
<212>  PRT
<213>  Mouse

<400>  11

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala His Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Ala Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  12
<211>  381
<212>  DNA
<213>  Mouse

<400>  12
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag tctggtatca acagaaacca      180

ggacactctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtctacaa cattttagta ctcctcggac gttcggtgga      360

ggcaccaacc tggaaatcaa a                                                381


<210>  13
<211>  127
<212>  PRT
<213>  Mouse

<400>  13

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Ile Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly His Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Phe 
            100                 105                 110         


Ser Thr Pro Arg Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
        115                 120                 125         


<210>  14
<211>  420
<212>  DNA
<213>  Mouse

<400>  14
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatact      240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg      300

cagatcaaca gcctcaaaac tgaggacacg gctacatatt tctgtgcaag aatggagtat      360

ggtaactacg aaaatgctat ggactcctgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  15
<211>  140
<212>  PRT
<213>  Mouse

<400>  15

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Met Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  16
<211>  381
<212>  DNA
<213>  Mouse

<400>  16
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacactgtga tgacccagtc tcacaaattc atgtccacat cagttggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgttg tctggtatca acaaaaacca      180

ggacaatctc ctaagctgct gatttactcg gcatcctacc ggtacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtctccaa cattttaata ttcctcggac gttcggtggg      360

ggcaccaagc tggaaatcaa a                                                381


<210>  17
<211>  127
<212>  PRT
<213>  Mouse

<400>  17

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Thr Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Phe 
            100                 105                 110         


Asn Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  18
<211>  414
<212>  DNA
<213>  Mouse

<400>  18
atggaatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag       60

gtccaattgc aacagtttgg agctgaggtg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggctacac attcactgac tacaacatag actgggtgaa gcagagccat      180

ggagagagtc ttgaatggat tggagatatt agtcctaatt ctgagggtac tacctacaac      240

cagaagttta agggacaggc cacattgact atagacaagt cctccaccac agcctacatg      300

gagctccgca gcctgacatc tgaggacagt gcagtctatt actgtgcaag agggagcggg      360

atctggaatg gtttggacta ctggggtcaa ggaacctctg tcaccgtctc ctca            414


<210>  19
<211>  138
<212>  PRT
<213>  Mouse

<400>  19

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Ile Asp Trp Val Lys Gln Ser His Gly Glu Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ser Pro Asn Ser Glu Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Gln Ala Thr Leu Thr Ile Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ser Gly Ile Trp Asn Gly Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  20
<211>  381
<212>  DNA
<213>  Mouse

<400>  20
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      180

ggacaatctc ctcaattact gatttattcg tcatcctacc ggtatgttgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggac ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtcaccaa cattatagtc tcccgtacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  21
<211>  127
<212>  PRT
<213>  Mouse

<400>  21

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Ser Ser Ser Tyr Arg Tyr Val Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln His Tyr 
            100                 105                 110         


Ser Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  22
<211>  423
<212>  DNA
<213>  Mouse

<400>  22
atgggcaggc ttacttcttc attcttgcta ctgattgtcc ctgcatatgt cctgtcccag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgttctttct ctgggttttc actgagtact tctggtatgg gtgtaggctg gattcgtcag      180

ccttcaggga agggtctgga gtggctgtca cacatttggt gggatgatga gaagcgctat      240

aacccagccc tgaagagccg actgacaatc tccaaggata cctccagcaa ccaggtattc      300

ctcaagatcg ccagtgtgga cactgcagat actgccacat actactgtgc tcgaataggg      360

gacaggtcgg gccacgcggg gtttgtttac tggggccaag ggactctggt cactgtctct      420

gca                                                                    423


<210>  23
<211>  141
<212>  PRT
<213>  Mouse

<400>  23

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ser His Ile Trp Trp Asp Asp Glu Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Asp Arg Ser Gly His Ala Gly Phe 
        115                 120                 125             


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210>  24
<211>  381
<212>  DNA
<213>  Mouse

<400>  24
atgaggaccc ctgctcagtt tcttggaatc ttattactct ggtttccagg tatcaaatgt       60

gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact      120

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      180

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      300

gaagatatgg gaacttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  25
<211>  127
<212>  PRT
<213>  Mouse

<400>  25

Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Met Gly Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  26
<211>  417
<212>  DNA
<213>  Mouse

<400>  26
atgtacttgg gactgaacta tgtattcatt gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgaatgggt tggtaaaatt agaagtgaaa ttaatgatca tgcaacatac      240

tatgctgagt ctgtgaaagg gaggttcacc atctcaagag atgattccaa aagtggtgtc      300

tacctgcaaa tgaacaactt aagagctgaa gacactggca tttattactg tgccagggat      360

ggttactacg gtgctatgga ctactggggt caaggaacgt cagtcaccgt ctcctca         417


<210>  27
<211>  139
<212>  PRT
<213>  Mouse

<400>  27

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Lys Ile Arg Ser Glu Ile Asn Asp His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Gly Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Ala Arg Asp Gly Tyr Tyr Gly Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  28
<211>  381
<212>  DNA
<213>  Mouse

<400>  28
atgaggttcc aggttcaggt tctggggctc cttctgctct ggatatcagg tgcccagtgt       60

gatgttcaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact      120

attaattgca ggtcaaataa gagcattagc agatatttag cctggtatca agagaaacct      180

gggaaaacta ataagcttct tatctactct ggatccactt tgcaatctgg aattccatca      240

aggttcagtg gcagtggatc taatacagat ttcactctca ccatcagtag cctggagcct      300

gaagattttg caatgtatta ctgtcaacag cataatgaat acccgtacac gttcggctcg      360

gggacaaaat tggaaataaa a                                                381


<210>  29
<211>  127
<212>  PRT
<213>  Mouse

<400>  29

Met Arg Phe Gln Val Gln Val Leu Gly Leu Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Gln Cys Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala 
            20                  25                  30          


Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ser Asn Lys Ser 
        35                  40                  45              


Ile Ser Arg Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Asn Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  30
<211>  414
<212>  DNA
<213>  Mouse

<400>  30
atgggatgga gctgtatcat cctcttcttg gtatcaacag gtacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgagctt gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagc tactggatgc actgggtgag gcagaggcct      180

ggacaaggcc ttgactggat cggagagatt gatccttctg atagttatat taactacaat      240

caaaagttca agggcaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

cagctcagca gcctgacatc tgaggactct gcggtctatt actgtggaag aaagagtctg      360

ggtgtctccg tgttagctta ctggggccaa gggactccgg tcactgtctc tgca            414


<210>  31
<211>  138
<212>  PRT
<213>  Mouse

<400>  31

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ser Thr Gly Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ile Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Arg Lys Ser Leu Gly Val Ser Val Leu Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Pro Val Thr Val Ser Ala 
    130                 135             


<210>  32
<211>  381
<212>  DNA
<213>  Mouse

<400>  32
atggagtcac agattcaggc atttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atctcctgca cggccagtca ggatgtgaat gctgctgtag cctggtatca acaaaaacca      180

gggcaatctc ccaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat tatactctca ccatcagcag tgtgcaggct      300

gaagacctgg cactttatta ctgtcagcaa cattatagca ctccgctcac gttcggtgct      360

gggaccaagc tggagctgaa a                                                381


<210>  33
<211>  127
<212>  PRT
<213>  Mouse

<400>  33

Met Glu Ser Gln Ile Gln Ala Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Ser Cys Thr Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  34
<211>  420
<212>  DNA
<213>  Mouse

<400>  34
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggacagtc aacatatgct      240

gatgacttca agggacgctt tgccttctct ttggaaacct ctgccagcac tgcccatttg      300

cagatcagca acctcaaaaa tgaggacgcg gctacatatt tctgtgcaag aatggagtat      360

ggtaactacg aaaatgcttt ggattactgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  35
<211>  140
<212>  PRT
<213>  Mouse

<400>  35

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala His Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Ala Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  36
<211>  381
<212>  DNA
<213>  Mouse

<400>  36
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag tctggtatca acagaaacca      180

ggacactctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtctacaa cattttagta ctcctcggac gttcggtgga      360

ggcaccaacc tggaaatcaa a                                                381


<210>  37
<211>  127
<212>  PRT
<213>  Mouse

<400>  37

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Ile Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly His Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Phe 
            100                 105                 110         


Ser Thr Pro Arg Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
        115                 120                 125         


<210>  38
<211>  420
<212>  DNA
<213>  Mouse

<400>  38
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatact      240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg      300

cagatcaaca gcctcaaaac tgaggacacg gctacatatt tctgtgcaag aatggagtat      360

ggtaactacg aaaatgctat ggactcctgg ggtcaaggaa cctcagtcac cgtctcctca      420


<210>  39
<211>  140
<212>  PRT
<213>  Mouse

<400>  39

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Met Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  40
<211>  381
<212>  DNA
<213>  Mouse

<400>  40
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacactgtga tgacccagtc tcacaaattc atgtccacat cagttggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgttg tctggtatca acaaaaacca      180

ggacaatctc ctaagctgct gatttactcg gcatcctacc ggtacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtctccaa cattttaata ttcctcggac gttcggtggg      360

ggcaccaagc tggaaatcaa a                                                381


<210>  41
<211>  127
<212>  PRT
<213>  Mouse

<400>  41

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Thr Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Phe 
            100                 105                 110         


Asn Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  42
<211>  414
<212>  DNA
<213>  Mouse

<400>  42
atggaatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag       60

gtccaattgc aacagtttgg agctgaggtg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaaggctt ctggctacac attcactgac tacaacatag actgggtgaa gcagagccat      180

ggagagagtc ttgaatggat tggagatatt agtcctaatt ctgagggtac tacctacaac      240

cagaagttta agggacaggc cacattgact atagacaagt cctccaccac agcctacatg      300

gagctccgca gcctgacatc tgaggacagt gcagtctatt actgtgcaag agggagcggg      360

atctggaatg gtttggacta ctggggtcaa ggaacctctg tcaccgtctc ctca            414


<210>  43
<211>  138
<212>  PRT
<213>  Mouse

<400>  43

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Ile Asp Trp Val Lys Gln Ser His Gly Glu Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ser Pro Asn Ser Glu Gly Thr Thr Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Gln Ala Thr Leu Thr Ile Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ser Gly Ile Trp Asn Gly Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             


<210>  44
<211>  381
<212>  DNA
<213>  Mouse

<400>  44
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      180

ggacaatctc ctcaattact gatttattcg tcatcctacc ggtatgttgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggac ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtcaccaa cattatagtc tcccgtacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  45
<211>  127
<212>  PRT
<213>  Mouse

<400>  45

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Ser Ser Ser Tyr Arg Tyr Val Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln His Tyr 
            100                 105                 110         


Ser Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  46
<211>  423
<212>  DNA
<213>  Mouse

<400>  46
atgggcaggc ttacttcttc attcttgcta ctgattgtcc ctgcatatgt cctgtcccag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgttctttct ctgggttttc actgagtact tctggtatgg gtgtaggctg gattcgtcag      180

ccttcaggga agggtctgga gtggctgtca cacatttggt gggatgatga gaagcgctat      240

aacccagccc tgaagagccg actgacaatc tccaaggata cctccagcaa ccaggtattc      300

ctcaagatcg ccagtgtgga cactgcagat actgccacat actactgtgc tcgaataggg      360

gacaggtcgg gccacgcggg gtttgtttac tggggccaag ggactctggt cactgtctct      420

gca                                                                    423


<210>  47
<211>  141
<212>  PRT
<213>  Mouse

<400>  47

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ser His Ile Trp Trp Asp Asp Glu Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Asp Arg Ser Gly His Ala Gly Phe 
        115                 120                 125             


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210>  48
<211>  381
<212>  DNA
<213>  Mouse

<400>  48
atgaggaccc ctgctcagtt tcttggaatc ttattactct ggtttccagg tatcaaatgt       60

gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact      120

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      180

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      300

gaagatatgg gaacttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      360

gggaccaagc tggaaataaa a                                                381


<210>  49
<211>  127
<212>  PRT
<213>  Mouse

<400>  49

Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Met Gly Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  50
<211>  417
<212>  DNA
<213>  Mouse

<400>  50
atgtacttgg gactgaacta tgtattcatt gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgaatgggt tggtaaaatt agaagtgaaa ttaatgatca tgcaacatac      240

tatgctgagt ctgtgaaagg gaggttcacc atctcaagag atgattccaa aagtggtgtc      300

tacctgcaaa tgaacaactt aagagctgaa gacactggca tttattactg tgccagggat      360

ggttactacg gtgctatgga ctactggggt caaggaacgt cagtcaccgt ctcctca         417


<210>  51
<211>  139
<212>  PRT
<213>  Mouse

<400>  51

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Lys Ile Arg Ser Glu Ile Asn Asp His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Gly Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Ala Arg Asp Gly Tyr Tyr Gly Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  52
<211>  381
<212>  DNA
<213>  Mouse

<400>  52
atgaggttcc aggttcaggt tctggggctc cttctgctct ggatatcagg tgcccagtgt       60

gatgttcaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact      120

attaattgca ggtcaaataa gagcattagc agatatttag cctggtatca agagaaacct      180

gggaaaacta ataagcttct tatctactct ggatccactt tgcaatctgg aattccatca      240

aggttcagtg gcagtggatc taatacagat ttcactctca ccatcagtag cctggagcct      300

gaagattttg caatgtatta ctgtcaacag cataatgaat acccgtacac gttcggctcg      360

gggacaaaat tggaaataaa a                                                381


<210>  53
<211>  127
<212>  PRT
<213>  Mouse

<400>  53

Met Arg Phe Gln Val Gln Val Leu Gly Leu Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Gln Cys Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala 
            20                  25                  30          


Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ser Asn Lys Ser 
        35                  40                  45              


Ile Ser Arg Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Asn Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  54
<211>  414
<212>  DNA
<213>  Mouse

<400>  54
atgggatgga gctgtatcat cctcttcttg gtatcaacag gtacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgagctt gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagc tactggatgc actgggtgag gcagaggcct      180

ggacaaggcc ttgactggat cggagagatt gatccttctg atagttatat taactacaat      240

caaaagttca agggcaaggc cacattgact gtagacaaat cctccagcac agcctacatg      300

cagctcagca gcctgacatc tgaggactct gcggtctatt actgtggaag aaagagtctg      360

ggtgtctccg tgttagctta ctggggccaa gggactccgg tcactgtctc tgca            414


<210>  55
<211>  138
<212>  PRT
<213>  Mouse

<400>  55

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ser Thr Gly Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Asp Trp Ile Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ile Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Arg Lys Ser Leu Gly Val Ser Val Leu Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Pro Val Thr Val Ser Ala 
    130                 135             


<210>  56
<211>  381
<212>  DNA
<213>  Mouse

<400>  56
atggagtcac agattcaggc atttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atctcctgca cggccagtca ggatgtgaat gctgctgtag cctggtatca acaaaaacca      180

gggcaatctc ccaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat tatactctca ccatcagcag tgtgcaggct      300

gaagacctgg cactttatta ctgtcagcaa cattatagca ctccgctcac gttcggtgct      360

gggaccaagc tggagctgaa a                                                381


<210>  57
<211>  127
<212>  PRT
<213>  Mouse

<400>  57

Met Glu Ser Gln Ile Gln Ala Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Ser Cys Thr Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  58
<211>  16
<212>  PRT
<213>  Mouse

<400>  58

Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp Tyr Trp 
1               5                   10                  15      


<210>  59
<211>  11
<212>  PRT
<213>  Mouse

<400>  59

Cys Leu Gln His Phe Ser Thr Pro Arg Thr Phe 
1               5                   10      


<210>  60
<211>  16
<212>  PRT
<213>  Mouse

<400>  60

Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Met Asp Ser Trp 
1               5                   10                  15      


<210>  61
<211>  11
<212>  PRT
<213>  Mouse

<400>  61

Cys Leu Gln His Phe Asn Ile Pro Arg Thr Phe 
1               5                   10      


<210>  62
<211>  14
<212>  PRT
<213>  Mouse

<400>  62

Cys Ala Arg Gly Ser Gly Ile Trp Asn Gly Leu Asp Tyr Trp 
1               5                   10                  


<210>  63
<211>  11
<212>  PRT
<213>  Mouse

<400>  63

Cys His Gln His Tyr Ser Leu Pro Tyr Thr Phe 
1               5                   10      


<210>  64
<211>  16
<212>  PRT
<213>  Mouse

<400>  64

Cys Ala Arg Ile Gly Asp Arg Ser Gly His Ala Gly Phe Val Tyr Trp 
1               5                   10                  15      


<210>  65
<211>  11
<212>  PRT
<213>  Mouse

<400>  65

Cys Leu Gln Tyr Asp Glu Phe Pro Tyr Thr Phe 
1               5                   10      


<210>  66
<211>  13
<212>  PRT
<213>  Mouse

<400>  66

Cys Ala Arg Asp Gly Tyr Tyr Gly Ala Met Asp Tyr Trp 
1               5                   10              


<210>  67
<211>  11
<212>  PRT
<213>  Mouse

<400>  67

Cys Gln Gln His Asn Glu Tyr Pro Tyr Thr Phe 
1               5                   10      


<210>  68
<211>  14
<212>  PRT
<213>  Mouse

<400>  68

Cys Gly Arg Lys Ser Leu Gly Val Ser Val Leu Ala Tyr Trp 
1               5                   10                  


<210>  69
<211>  11
<212>  PRT
<213>  Mouse

<400>  69

Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  70
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric mAb

<400>  70
atgggcaggc ttacttcttc attcttgcta ctgattgtcc ctgcatatgt cctgtcccag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgttctttct ctgggttttc actgagtact tctggtatgg gtgtaggctg gattcgtcag      180

ccttcaggga agggtctgga gtggctgtca cacatttggt gggatgatga gaagcgctat      240

aacccagccc tgaagagccg actgacaatc tccaaggata cctccagcaa ccaggtattc      300

ctcaagatcg ccagtgtgga cactgcagat actgccacat actactgtgc tcgaataggg      360

gacaggtcgg gccacgcggg gtttgtttac tggggccaag ggactctggt cactgtctct      420

gcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctggcg      780

ggaccggacg tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccgagga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1140

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcacg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaa                                  1413


<210>  71
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric mAb

<400>  71

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ser His Ile Trp Trp Asp Asp Glu Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Asp Arg Ser Gly His Ala Gly Phe 
        115                 120                 125             


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  72
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric antibody

<400>  72
atgaggaccc ctgctcagtt tcttggaatc ttattactct ggtttccagg tatcaaatgt       60

gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact      120

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      180

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      300

gaagatatgg gaacttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      360

gggaccaagc tggaaataaa aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             699


<210>  73
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse-human chimeric antibody

<400>  73

Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Met Gly Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  74
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-human chimeric antibody

<400>  74
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatact      240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg      300

cagatcaaca gcctcaaaac tgaggacacg gctacatatt tctgtgcaag aatggagtat      360

ggtaactacg aaaatgctat ggactcctgg ggtcaaggaa cctcagtcac cgtctcctca      420

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctggcggga      780

ccggacgtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccgaggagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcacgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa                                      1410


<210>  75
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse-human chimeric antibody

<400>  75

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Met Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  76
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse-human chimeric antibody

<400>  76
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacactgtga tgacccagtc tcacaaattc atgtccacat cagttggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgttg tctggtatca acaaaaacca      180

ggacaatctc ctaagctgct gatttactcg gcatcctacc ggtacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtctccaa cattttaata ttcctcggac gttcggtggg      360

ggcaccaagc tggaaatcaa aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             699


<210>  77
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse-human chimeric antibody

<400>  77

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Thr Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Phe 
            100                 105                 110         


Asn Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  78
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  78
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcg       60

atggcccaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

aagatctcct gcaaggcttc tgggtatacc ttcacaaact atggaatgaa ctgggtgaag      180

caggctccag gaaagggttt aaagtggatg ggctggataa acacctacac tggacagtca      240

acatatgctg atgacttcaa gggacgcttt gccttctctt tggaaacctc tgccagcact      300

gcccatttgc agatcagcaa cctcaaaaat gaggacgcgg ctacatattt ctgtgcaaga      360

atggagtatg gtaactacga aaatgctttg gattactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gtggcggtgg cagcggcggc ggtggtagcg gtggtggcgg cagcgacatt      480

gtgatgaccc agtctcacaa attcatgtcc acatcaatag gagacagggt cagcatcacc      540

tgcaaggcca gtcaggatgt gagtactgct gtagtctggt atcaacagaa accaggacac      600

tctcctaaac tactgattta ttcggcatcc taccggtaca ctggagtccc tgatcgcttc      660

actggcagtg gatctgggac ggatttcact ttcaccatca gcagtgtgca ggctgaagac      720

ctggcagttt attactgtct acaacatttt agtactcctc ggacgttcgg tggaggcacc      780

aacctggaaa tcaaa                                                       795


<210>  79
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  79

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala His Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Ala Ala Thr Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn 
        115                 120                 125             


Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly Asp Arg 
                165                 170                 175     


Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Val 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile Tyr Ser 
        195                 200                 205             


Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp 
225                 230                 235                 240 


Leu Ala Val Tyr Tyr Cys Leu Gln His Phe Ser Thr Pro Arg Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            260                 265 


<210>  80
<211>  121
<212>  PRT
<213>  Mouse

<400>  80

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala His 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Ala Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  81
<211>  121
<212>  PRT
<213>  Human

<400>  81

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Glu Asn Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  107
<212>  PRT
<213>  Mouse

<400>  82

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Leu Gln His Phe Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105         


<210>  83
<211>  107
<212>  PRT
<213>  Human

<400>  83

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Gln Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Arg Thr Asp Phe Thr Phe Thr Ile Asn Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys His Gln His Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  84
<211>  121
<212>  PRT
<213>  Human

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Ala Thr Ile Asp Glu Asn Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  85
<211>  120
<212>  PRT
<213>  Human

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gln Trp Phe Gly Glu Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  86
<211>  120
<212>  PRT
<213>  Human

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gln Trp Met Gly Met Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  87
<211>  107
<212>  PRT
<213>  Human

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  88
<211>  107
<212>  PRT
<213>  Human

<400>  88

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  89
<211>  107
<212>  PRT
<213>  Human

<400>  89

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  90
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  90

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  91

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Phe Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  92

Asp Asn Lys Gln 
1               


<210>  93
<211>  19
<212>  PRT
<213>  Escherichia coli

<400>  93

Val Glu Lys Asn Ile Thr Val Thr Ala Ser Val Asp Pro Val Ile Asp 
1               5                   10                  15      


Leu Leu Gln 
            


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis tag

<400>  94

Leu Glu His His His His His His 
1               5               


<210>  95
<211>  19
<212>  PRT
<213>  Escherichia coli

<400>  95

Val Glu Lys Asn Ile Thr Val Arg Ala Ser Val Asp Pro Lys Leu Asp 
1               5                   10                  15      


Leu Leu Gln 
            


<210>  96
<211>  19
<212>  PRT
<213>  Escherichia coli

<400>  96

Ala Glu Lys Asn Ile Thr Val Thr Ala Ser Val Asp Pro Thr Ile Asp 
1               5                   10                  15      


Leu Met Gln 
            


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  97

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  98

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  99
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  99

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  100
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pelB leader sequence

<400>  100

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  101
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant pelB leader sequence

<400>  101

Met Lys Tyr Leu Leu Pro Thr Ala Glu Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  102
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  malE leader sequence

<400>  102

Met Lys Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr Thr 
1               5                   10                  15      


Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25  


<210>  103
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant malE leader sequence

<400>  103

Met Lys Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Glu Leu Thr Thr 
1               5                   10                  15      


Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25  


<210>  104
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DsbA leader sequence

<400>  104

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala Ala Gln 
            20      


<210>  105
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OmpA leader sequence

<400>  105

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala 
            20      


<210>  106
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PhoA leader sequence

<400>  106

Val Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala 
            20      


<210>  107
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  107
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcg       60

atggcccaga tccagttggt gcagtctgga cctgagctga agaagcctgg agagacagtc      120

aagatctcct gcaaggcttc tgggtatacc ttcacaaact atggaatgaa ctgggtgaag      180

caggctccag gaaagggttt aaagtggatg ggctggataa acacctacac tggacagtca      240

acctatgctg atgacttcaa gggacgcttt gccttctctt tggaaacctc tgccagcact      300

gcccatttgc agatcagcaa cctcaaaaat gaggacgcgg ctacatattt ctgtgcaaga      360

atggagtatg gtaactacga aaatgctttg gattactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gtggcggtgg cagcggcggc ggtggtagcg gtggtggcgg cagcgacatt      480

gtgatgaccc agtctcacaa attcatgtcc acatcaatag gagacagggt cagcatcacc      540

tgcaaggcca gtcaggatgt gagtactgct gtagtctggt atcaacagaa accaggacac      600

tctcctaaac tactgattta ttcggcatcc taccggtaca ctggagtccc tgatcgcttc      660

actggcagtg gatctgggac ggatttcact ttcaccatca gcagtgtgca ggctgaagac      720

ctggcagttt attactgtct acaacatttt agtactcctc ggacgttcgg tggaggcacc      780

aacctggaaa tcaaa                                                       795


<210>  108
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  108

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala His Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Ala Ala Thr Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn 
        115                 120                 125             


Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly Asp Arg 
                165                 170                 175     


Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Val 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile Tyr Ser 
        195                 200                 205             


Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp 
225                 230                 235                 240 


Leu Ala Val Tyr Tyr Cys Leu Gln His Phe Ser Thr Pro Arg Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            260                 265 


<210>  109
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  109
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcg       60

atggcccaga tccagttggt gcagtctgga tctgagctga agaagcctgg agcgtcagtc      120

aaggtctcct gcaaggcttc tgggtatacc ttcacaaact atggaatgaa ctgggtgaag      180

caggctccag gacagggttt aaagtggatg ggctggataa acacctacac tggacagtca      240

acctatgctg atgacttcaa gggacgcttt gccttctctt tggatacctc tgtcagcact      300

gcctatttgc agatcagcag cctcaaagct gaggacacgg ctgtgtattt ctgtgcaaga      360

atggagtatg gtaactacga aaatgctttg gattactggg gtcaaggaac cttagtcacc      420

gtctcctcag gtggcggtgg cagcggcggc ggtggtagcg gtggtggcgg cagcgacatt      480

gtgatgaccc agtctcccag ctccctgtcc gcatcagtag gagacagggt caccatcacc      540

tgcaaggcca gtcaggatgt gagtactgct gtagtctggt atcaacagaa accaggaaaa      600

gctcctaaac tactgattta ttcggcatcc taccggtaca ctggagtccc tgatcgcttc      660

actggcagtg gatctgggac ggatttcact ttgaccatca gcagtctgca ggctgaagac      720

ttcgcaacct attactgtct acaacatttt agtactcctc ggacgttcgg tggaggcacc      780

aaactggaaa tcaaa                                                       795


<210>  110
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  110

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Ile Gln Leu Val Gln Ser Gly Ser Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn 
        115                 120                 125             


Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala Val Val 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser 
        195                 200                 205             


Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Leu Gln His Phe Ser Thr Pro Arg Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265 


<210>  111
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  111
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcg       60

atggccgaca ttgtgatgac ccagtctccc agctccctgt ccgcatcagt aggagacagg      120

gtcaccatca cctgcaaggc cagtcaggat gtgagtactg ctgtagtctg gtatcaacag      180

aaaccaggaa aagctcctaa actactgatt tattcggcat cctaccggta cactggagtc      240

cctgatcgct tcactggcag tggatctggg acggatttca ctttgaccat cagcagtctg      300

caggctgaag acttcgcaac ctattactgt ctacaacatt ttagtactcc tcggacgttc      360

ggtggaggca ccaaactgga aatcaaaggt ggcggtggca gcggcggcgg tggtagcggt      420

ggtggcggca gccagatcca gttggtgcag tctggatctg agctgaagaa gcctggagcg      480

tcagtcaagg tctcctgcaa ggcttctggg tataccttca caaactatgg aatgaactgg      540

gtgaagcagg ctccaggaca gggtttaaag tggatgggct ggataaacac ctacactgga      600

cagtcaacct atgctgatga cttcaaggga cgctttgcct tctctttgga tacctctgtc      660

agcactgcct atttgcagat cagcagcctc aaagctgagg acacggctgt gtatttctgt      720

gcaagaatgg agtatggtaa ctacgaaaat gctttggatt actggggtca aggaacctta      780

gtcaccgtct cctca                                                       795


<210>  112
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  112

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


His Phe Ser Thr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
                165                 170                 175     


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
            180                 185                 190         


Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser Thr Tyr Ala Asp Asp Phe 
        195                 200                 205             


Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
225                 230                 235                 240 


Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


<210>  113
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  113
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg atctgagctg aagaagcctg gagcgtcagt caaggtctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggacagggtt taaagtggat gggctggata aacacctaca ctggacagtc aacctatgct      240

gatgacttca agggacgctt tgccttctct ttggatacct ctgtcagcac tgcctatttg      300

cagatcagca gcctcaaagc tgaggacacg gctgtgtatt tctgtgcaag aatggagtat      360

ggtaactacg aaaatgcttt ggattactgg ggtcaaggaa ccttagtcac cgtctcctca      420

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      480

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctggcggga      780

ccggacgtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      960

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccgaggagaa aaccatctcc     1080

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcacgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa                                      1410


<210>  114
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  114

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Gln Ser Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Met Glu Tyr Gly Asn Tyr Glu Asn Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  115
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  115
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcccagctcc ctgtccgcat cagtaggaga cagggtcacc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag tctggtatca acagaaacca      180

ggaaaagctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggat ttcactttga ccatcagcag tctgcaggct      300

gaagacttcg caacctatta ctgtctacaa cattttagta ctcctcggac gttcggtgga      360

ggcaccaaac tggaaatcaa aacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             699


<210>  116
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody

<400>  116

Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Phe 
            100                 105                 110         


Ser Thr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  117
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  117
catatgatga aatacctatt gcctacggca gccgctggat tgttattact cgcggcccag       60

ccggcgatgg cccagatcca gttggtgcag tctggacctg agctgaagaa gcctggagag      120

acagtcaaga tctcctgcaa ggcttctggg tataccttca caaactatgg aatgaactgg      180

gtgaagcagg ctccaggaaa gggtttaaag tggatgggct ggataaacac ctacactgga      240

cagtcaacat atgctgatga cttcaaggga cgctttgcct tctctttgga aacctctgcc      300

agcactgccc atttgcagat cagcaacctc aaaaatgagg acgcggctac atatttctgt      360

gcaagaatgg agtatggtaa ctacgaaaat gctttggatt actggggtca aggaacctca      420

gtcaccgtct cctcaggtgg cggtggcagc ggcggcggtg gtagcggtgg tggcggcagc      480

gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcagc      540

atcacctgca aggccagtca ggatgtgagt actgctgtag tctggtatca acagaaacca      600

ggacactctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      660

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      720

gaagacctgg cagtttatta ctgtctacaa cattttagta ctcctcggac gttcggtgga      780

ggcaccaacc tggaaatcaa actcgag                                          807


<210>  118
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  118
cctacactgg acagtcaacc tatgctgatg acttcaaggg acgc                        44


<210>  119
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  119
gcgtcccttg aagtcatcag cataggttga ctgtccagtg tagg                        44


<210>  120
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  120
catatgatga aatacctatt gcctacggca gccgctggat tgttattact cgcggcccag       60

ccggcgatgg cccagatcca gttggtgcag tctggacctg agctgaagaa gcctggagag      120

acagtcaaga tctcctgcaa ggcttctggg tataccttca caaactatgg aatgaactgg      180

gtgaagcagg ctccaggaaa gggtttaaag tggatgggct ggataaacac ctacactgga      240

cagtcaacct atgctgatga cttcaaggga cgctttgcct tctctttgga aacctctgcc      300

agcactgccc atttgcagat cagcaacctc aaaaatgagg acgcggctac atatttctgt      360

gcaagaatgg agtatggtaa ctacgaaaat gctttggatt actggggtca aggaacctca      420

gtcaccgtct cctcaggtgg cggtggcagc ggcggcggtg gtagcggtgg tggcggcagc      480

gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcagc      540

atcacctgca aggccagtca ggatgtgagt actgctgtag tctggtatca acagaaacca      600

ggacactctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      660

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      720

gaagacctgg cagtttatta ctgtctacaa cattttagta ctcctcggac gttcggtgga      780

ggcaccaacc tggaaatcaa actcgag                                          807


<210>  121
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  121
catatgatga aatacctatt gcctacggca gccgctggat tgttattact cgcggcccag       60

ccggcgatgg cccagatcca gttggtgcag tctggatctg agctgaagaa gcctggagcg      120

tcagtcaagg tctcctgcaa ggcttctggg tataccttca caaactatgg aatgaactgg      180

gtgaagcagg ctccaggaca gggtttaaag tggatgggct ggataaacac ctacactgga      240

cagtcaacct atgctgatga cttcaaggga cgctttgcct tctctttgga tacctctgtc      300

agcactgcct atttgcagat cagcagcctc aaagctgagg acacggctgt gtatttctgt      360

gcaagaatgg agtatggtaa ctacgaaaat gctttggatt actggggtca aggaacctta      420

gtcaccgtct cctcaggtgg cggtggcagc ggcggcggtg gtagcggtgg tggcggcagc      480

gacattgtga tgacccagtc tcccagctcc ctgtccgcat cagtaggaga cagggtcacc      540

atcacctgca aggccagtca ggatgtgagt actgctgtag tctggtatca acagaaacca      600

ggaaaagctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      660

cgcttcactg gcagtggatc tgggacggat ttcactttga ccatcagcag tctgcaggct      720

gaagacttcg caacctatta ctgtctacaa cattttagta ctcctcggac gttcggtgga      780

ggcaccaaac tggaaatcaa actcgag                                          807


<210>  122
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  122
catatgatga aatacctatt gcctacggca gccgctggat tgttattact cgcggcccag       60

ccggcgatgg ccgacattgt gatgacccag tctcccagct ccctgtccgc atcagtagga      120

gacagggtca ccatcacctg caaggccagt caggatgtga gtactgctgt agtctggtat      180

caacagaaac caggaaaagc tcctaaacta ctgatttatt cggcatccta ccggtacact      240

ggagtccctg atcgcttcac tggcagtgga tctgggacgg atttcacttt gaccatcagc      300

agtctgcagg ctgaagactt cgcaacctat tactgtctac aacattttag tactcctcgg      360

acgttcggtg gaggcaccaa actggaaatc aaaggtggcg gtggcagcgg cggcggtggt      420

agcggtggtg gcggcagcca gatccagttg gtgcagtctg gatctgagct gaagaagcct      480

ggagcgtcag tcaaggtctc ctgcaaggct tctgggtata ccttcacaaa ctatggaatg      540

aactgggtga agcaggctcc aggacagggt ttaaagtgga tgggctggat aaacacctac      600

actggacagt caacctatgc tgatgacttc aagggacgct ttgccttctc tttggatacc      660

tctgtcagca ctgcctattt gcagatcagc agcctcaaag ctgaggacac ggctgtgtat      720

ttctgtgcaa gaatggagta tggtaactac gaaaatgctt tggattactg gggtcaagga      780

accttagtca ccgtctcctc actcgag                                          807


