                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  HUMAN ANTI-CD33 ANTIBODIES AND USES THEREOF

<130>  F053-0123PCT / 20-160-WO-PCT

<150>  US 63/003,203
<151>  2020-03-31

<160>  260   

<170>  PatentIn version 3.5

<210>  1
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 4D protein

<400>  1

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly 
145                 150                 155                 160 


Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser Trp 
                165                 170                 175     


Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala Ala 
            180                 185                 190         


Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile Ile 
        195                 200                 205             


Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu Asn Val 
225                 230                 235                 240 


Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly Asp Gly 
                245                 250                 255     


Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Pro Glu Pro Ser 
            260                 265                 270         


Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu 
        275                 280                 285             


Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp 
    290                 295                 300                 


Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His 
305                 310                 315                 320 


Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala 
                325                 330                 335     


Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp 
            340                 345                 350         


Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met 
        355                 360                 365             


Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser 
    370                 375                 380                 


Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp 
385                 390                 395                 400 


Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp 
                405                 410                 415     


Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala 
            420                 425                 430         


Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val 
        435                 440                 445             


Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser 
    450                 455                 460                 


Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe 
465                 470                 475                 480 


Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe 
                485                 490                 495     


Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn 
            500                 505                 510         


Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu 
        515                 520                 525             


Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val 
    530                 535                 540                 


Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro 
545                 550                 555                 560 


Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro 
                565                 570                 575     


Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser 
            580                 585                 590         


Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser 
        595                 600                 605             


Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Gly Ala Ile 
    610                 615                 620                 


Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu Ile 
625                 630                 635                 640 


Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val 
                645                 650                 655     


Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His 
            660                 665                 670         


Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser 
        675                 680                 685             


Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser 
    690                 695                 700                 


Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr 
705                 710                 715                 720 


Ser Glu Val Arg Thr Gln 
                725     


<210>  2
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human full-length (FL)CD33 with a mouse Fc domain, used as an 
       immunogen for human FL CD33

<400>  2

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Gly Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
            260                 265                 270         


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
        275                 280                 285             


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
305                 310                 315                 320 


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
                325                 330                 335     


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
    370                 375                 380                 


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
385                 390                 395                 400 


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
                405                 410                 415     


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
            420                 425                 430         


Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
        435                 440                 445             


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
    450                 455                 460                 


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  3
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human delta E2 version of CD33 (CD33 delta E2) with a mouse Fc 
       domain, used as immunogen for human CD33 delta E2

<400>  3

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Gly Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
    130                 135                 140                 


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
                165                 170                 175     


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
            180                 185                 190         


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
        195                 200                 205             


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
                245                 250                 255     


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
            260                 265                 270         


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
        275                 280                 285             


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
    290                 295                 300                 


Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
305                 310                 315                 320 


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
                325                 330                 335     


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  4
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 where the C2-set Ig-like 
       domain from mouse is replaced with the C2-set Ig-like domain from
       human CD33, combined with a Fc region from human lgG1, used as 
       immunogen to generate antibodies against human C2-set domain of

<400>  4

Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      


Gln Asp Leu Glu Phe Gln Leu Val Ala Pro Glu Ser Val Thr Val Glu 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Val Phe Tyr Pro Ser Ile 
        35                  40                  45              


Lys Leu Thr Leu Gly Pro Val Thr Gly Ser Trp Leu Arg Lys Gly Val 
    50                  55                  60                  


Ser Leu His Glu Asp Ser Pro Val Ala Thr Ser Asp Pro Arg Gln Leu 
65                  70                  75                  80  


Val Gln Lys Ala Thr Gln Gly Arg Phe Gln Leu Leu Gly Asp Pro Gln 
                85                  90                  95      


Lys His Asp Cys Ser Leu Phe Ile Arg Asp Ala Gln Lys Asn Asp Thr 
            100                 105                 110         


Gly Met Tyr Phe Phe Arg Val Val Arg Glu Pro Phe Val Arg Tyr Ser 
        115                 120                 125             


Tyr Lys Lys Ser Gln Leu Ser Leu His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210>  5
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 (codon optimized) where the 
       C2-set Ig-like domain from mouse is replaced with the C2-set 
       Ig-like domain from human CD33, combined with a Fc region from 
       human lgG1

<400>  5
atgctgtggc ctctgcctct gtttctgctg tgcgctggaa gtctggctca ggatctggaa       60

tttcagctgg tggctcccga atcagtcacc gtggaggagg gcctgtgcgt gcacgtgcct      120

tgtagcgtgt tctacccaag catcaagctg accctgggcc ctgtgacagg ctcctggctg      180

aggaagggcg tgtccctgca cgaggactct ccagtggcca ccagcgatcc taggcagctg      240

gtgcagaagg ccacacaggg cagattccag ctgctgggcg accctcagaa gcacgattgc      300

agcctgttta tccgcgacgc ccagaagaac gataccggca tgtatttctt tcgggtggtg      360

agagagccat tcgtgaggta ctcctataag aagtctcagc tgagcctgca cgtgaccgac      420

ctgacacacc gcccaaagat cctgatccca ggcaccctgg agcctggaca ctctaagaac      480

ctgacatgct ccgtgtcttg ggcatgtgag cagggaaccc cacctatctt ttcctggctg      540

tctgccgcac caacaagcct gggaccaagg accacacaca gctccgtgct gatcatcacc      600

cctagaccac aggatcacgg caccaatctg acatgccagg tgaagttcgc aggagcagga      660

gtgaccacag agaggaccat ccagctgaac gtgacatacg tgcctcagaa tccaaccaca      720

ggcatctttc caggcgacgg ctccggcaag caggagacac gggccggatc cgagcccaag      780

tctagcgata agacccacac atgcccacca tgtccagcac ctgagctgct gggaggacca      840

agcgtgttcc tgtttcctcc aaagcccaag gacacactga tgatctctcg gacccccgag      900

gtgacatgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt taactggtac      960

gtggatggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaactcc     1020

acctatcgcg tggtgtctgt gctgacagtg ctgcaccagg actggctgaa cggcaaggag     1080

tataagtgca aggtgtccaa taaggccctg ccagccccca tcgagaagac catctctaag     1140

gcaaagggac agcccaggga gcctcaggtg tacacactgc cccctagccg cgacgagctg     1200

accaagaacc aggtgtccct gacatgtctg gtgaagggct tctatccttc tgatatcgcc     1260

gtggagtggg agagcaatgg ccagccagag aacaattaca agaccacacc acccgtgctg     1320

gacagcgatg gctccttctt tctgtatagc aagctgaccg tggataagtc caggtggcag     1380

cagggcaacg tgttcagctg ttccgtgatg cacgaagcac tgcacaacca ctacactcag     1440

aaatcactgt cactgtcccc aggaaagtaa                                      1470


<210>  6
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECD of mouse CD33; C2-set Ig-like domain of human CD33 combined 
       with the transmembrane domain and a truncated intracellular 
       domain both derived from human CD33

<400>  6

Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      


Gln Asp Leu Glu Phe Gln Leu Val Ala Pro Glu Ser Val Thr Val Glu 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Val Phe Tyr Pro Ser Ile 
        35                  40                  45              


Lys Leu Thr Leu Gly Pro Val Thr Gly Ser Trp Leu Arg Lys Gly Val 
    50                  55                  60                  


Ser Leu His Glu Asp Ser Pro Val Ala Thr Ser Asp Pro Arg Gln Leu 
65                  70                  75                  80  


Val Gln Lys Ala Thr Gln Gly Arg Phe Gln Leu Leu Gly Asp Pro Gln 
                85                  90                  95      


Lys His Asp Cys Ser Leu Phe Ile Arg Asp Ala Gln Lys Asn Asp Thr 
            100                 105                 110         


Gly Met Tyr Phe Phe Arg Val Val Arg Glu Pro Phe Val Arg Tyr Ser 
        115                 120                 125             


Tyr Lys Lys Ser Gln Leu Ser Leu His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr 
        275                 280                 


<210>  7
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 where the C2-set Ig-like 
       domain from mouse has been replaced with the C2-set Ig-like 
       domain from human CD33 combined with the transmembrane domain and
       a truncated intracellular domain both derived from human CD33

<400>  7
atgctgtggc ctctgcctct gtttctgctg tgcgctggaa gtctggctca ggatctggaa       60

tttcagctgg tggctcccga atcagtcacc gtggaggagg gcctgtgcgt gcacgtgcct      120

tgtagcgtgt tctacccaag catcaagctg accctgggcc ctgtgacagg ctcctggctg      180

aggaagggcg tgtccctgca cgaggactct ccagtggcca ccagcgatcc taggcagctg      240

gtgcagaagg ccacacaggg cagattccag ctgctgggcg accctcagaa gcacgattgc      300

agcctgttta tccgcgacgc ccagaagaac gataccggca tgtatttctt tcgggtggtg      360

agagagccat tcgtgaggta ctcctataag aagtctcagc tgagcctgca cgtgaccgac      420

ctgacacacc gcccaaagat cctgatccca ggcaccctgg agcctggaca ctctaagaac      480

ctgacatgct ccgtgtcttg ggcatgtgag cagggaaccc cacctatctt ttcctggctg      540

tctgccgcac caacaagcct gggaccaagg accacacaca gctccgtgct gatcatcacc      600

cctagaccac aggatcacgg caccaatctg acatgccagg tgaagttcgc aggagcagga      660

gtgaccacag agaggaccat ccagctgaac gtgacatacg tgcctcagaa tccaaccaca      720

ggcatctttc caggcgacgg ctccggcaag caggagacac gggccggagt ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cctga                                                       855


<210>  8
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Leu Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Ser Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Asn Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  9
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  9
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggctat ggatccaaat       60

ttctggctgc aagtgcagga gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc      120

tgcactttct tccatcccat accctactac gacaagaact ccccagttca tggttactgg      180

ttccgggaag gagccattat atccagggac tctccagtgg ccacaaacaa gctagatcaa      240

gaagtacagg aggagactca gggcagattc cgcctccttg gggatcccag taggaacaac      300

tgctccctga gcatcgtaga cgccaggagg agggataatg gttcatactt ctttcggatg      360

gagagaggaa gtaccaaata cagttacaaa tctccccagc tctctgtgca tgtgacagac      420

ttgacccaca ggcccaaaat cctcatccct ggcactctag aacccggcca ctccaaaaac      480

cttacctgct ctgtgtcctg ggcctgtgag cagggaacac ccccgatctt ctcctggttg      540

tcagctgccc ccacctccct gggccccagg actactcact cctcggtgct cataatcacc      600

ccacggcccc aggaccacgg caccaacctg acctgtcagg tgaagttcgc tggagctggt      660

gtgactacgg agagaaccat ccagctcaac gtcacctatg ttccacagaa cccaacaact      720

ggtatctttc caggagatgg ctcagggaaa caagagacca gagcaggact ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cccacaggag gaaagcagcc aggacagcag tgggcagcaa tgacacccac      900

cctaccacag ggtcagcctc cccgaaacac cagaagaact ccaagttaca tggccccact      960

gaaacctcaa gctgttcagg tgccgcccct actgtggaga tggatgagga gctgcattat     1020

gcttccctca actttcatgg gatgaatcct tccaaggaca cctccaccga atactcagag     1080

gtcaggaccc agtga                                                      1095


<210>  10
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Leu Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu 
    130                 135                 140                 


Ala Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg 
145                 150                 155                 160 


Lys Ala Ala Arg Thr Ala Val Gly Ser Asn Asp Thr His Pro Thr Thr 
                165                 170                 175     


Gly Ser Ala Ser Pro Lys His Gln Lys Asn Ser Lys Leu His Gly Pro 
            180                 185                 190         


Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp 
        195                 200                 205             


Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser 
    210                 215                 220                 


Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
225                 230                 235         


<210>  11
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  11
atgccgctgc tgctactgct gcccctgctg tgggcagact tgacccacag gcccaaaatc       60

ctcatccctg gcactctaga acccggccac tccaaaaacc ttacctgctc tgtgtcctgg      120

gcctgtgagc agggaacacc cccgatcttc tcctggttgt cagctgcccc cacctccctg      180

ggccccagga ctactcactc ctcggtgctc ataatcaccc cacggcccca ggaccacggc      240

accaacctga cctgtcaggt gaagttcgct ggagctggtg tgactacgga gagaaccatc      300

cagctcaacg tcacctatgt tccacagaac ccaacaactg gtatctttcc aggagatggc      360

tcagggaaac aagagaccag agcaggactg gttcatgggg ccattggagg agctggtgtt      420

acagccctgc tcgctctttg tctctgcctc atcttcttca tagtgaagac ccacaggagg      480

aaagcagcca ggacagcagt gggcagcaat gacacccacc ctaccacagg gtcagcctcc      540

ccgaaacacc agaagaactc caagttacat ggccccactg aaacctcaag ctgttcaggt      600

gccgccccta ctgtggagat ggatgaggag ctgcattatg cttccctcaa ctttcatggg      660

atgaatcctt ccaaggacac ctccaccgaa tactcagagg tcaggaccca gtga            714


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H10

<400>  12

Arg Ala Ser Gln Gly Ile Arg Ile Tyr Leu Gly 
1               5                   10      


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H10 and/or 1D2

<400>  13

Tyr Ala Thr Ser Ser Leu Gln Ser 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1H10

<400>  14

Leu Gln Asp Tyr Asn Tyr Pro Trp Thr 
1               5                   


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H10

<400>  15

Lys Gly Ser Gly Tyr Ile Phe Thr Ser Tyr Asp Met His 
1               5                   10              


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H10

<400>  16

Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser 
1               5                   10  


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H10

<400>  17

Thr Arg Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1A9 and/or 1B9

<400>  18

Arg Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1A9

<400>  19

Tyr Gly Ala Ser Ser Leu Gln Ser 
1               5               


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1A9

<400>  20

Leu Gln Glu Tyr Asn Tyr Pro Cys Thr 
1               5                   


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1A9

<400>  21

Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Asp Met His 
1               5                   10              


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1A9

<400>  22

Ala Ile Gly Thr Ala Gly Asp Thr Tyr 
1               5                   


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1A9

<400>  23

Ala Arg Glu Tyr Ser Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1E6 and/or 1D2

<400>  24

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1E6

<400>  25

Tyr Ala Ala Ser Asn Leu Gln Ser 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1E6, 1D2, and/or 1B9

<400>  26

Leu Gln Asp Tyr Ser Tyr Pro Arg Thr 
1               5                   


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1E6 and/or 1D2

<400>  27

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Ile His 
1               5                   10              


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1E6 and/or 1D2

<400>  28

Val Ile Trp Tyr Asp Gly Ser His Asn Tyr 
1               5                   10  


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1E6 and/or 1D2

<400>  29

Ala Arg Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr 
1               5                   10      


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1D2

<400>  30

Val Ile Trp Tyr Asp Gly Ser Gln Lys Tyr 
1               5                   10  


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1B9

<400>  31

Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5               


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1B9

<400>  32

Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr Asp Ile His 
1               5                   10              


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1B9

<400>  33

Ala Arg Asp Tyr Ser Gly Ser Tyr Phe Asp Tyr 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H8

<400>  34

Arg Ala Ser Gln Asn Ile Gly Gly Asn Leu His 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H8

<400>  35

Tyr Ala Thr Gln Pro Phe Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1H8

<400>  36

His Gln Ser Ser Ser Leu Pro Leu Thr 
1               5                   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H8 and/or 2E3

<400>  37

Ser Tyr Gly Met His 
1               5   


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H8

<400>  38

Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H8

<400>  39

Asp Leu Asp Tyr Asp Ser Ser Gly 
1               5               


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D3

<400>  40

Gln Ser Gly Ser Ser Ser Phe Leu Ser 
1               5                   


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2D3

<400>  41

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 2D3

<400>  42

Gln Gln Asp Tyr Asn Leu Pro Phe Thr 
1               5                   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D3

<400>  43

Ile Tyr Ala Met Ser 
1               5   


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D3

<400>  44

Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D3

<400>  45

Arg Thr Arg Tyr Phe Asn Gly 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2E3

<400>  46

Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2E3

<400>  47

Gly Thr Ser Ser Arg Ala Thr 
1               5           


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 2E3

<400>  48

Gln Gln Tyr Gly Ser Ser Pro Thr 
1               5               


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2E3

<400>  49

Ile Trp Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2E3

<400>  50

Asp Gly Thr Gly Glu Asn Tyr Tyr Tyr Tyr Val 
1               5                   10      


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 variable light chain

<400>  51

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ile Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 variable heavy chain

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Met Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 variable light chain

<400>  53

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Tyr Asn Tyr Pro Cys 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 variable heavy chain

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Tyr Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 variable light chain

<400>  55

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  56
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 variable heavy chain

<400>  56

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D2 variable light chain

<400>  57

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  58
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D2 variable heavy chain

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Gln Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B9 variable light chain

<400>  59

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Leu Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys 
            100                 105         


<210>  60
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B9 variable heavy chain

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H8 variable light chain

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Gly Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Arg Tyr Ala Thr Gln Pro Phe Ser Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H8 variable heavy chain

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys His Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asp Tyr Asp Ser Ser Gly Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ile Leu Val Leu Val Ser Ser 
        115                 120 


<210>  63
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 variable light chain

<400>  63

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Ser Ser Ser 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  64
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 variable heavy chain

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Thr Arg Tyr Phe Asn Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E3 variable light chain

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2E3 variable heavy chain

<400>  66

Gln Val Cys Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Thr Gly Glu Asn Tyr Tyr Tyr Tyr Val Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120         


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of OKT3

<400>  67

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of OKT3

<400>  68

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of OKT3

<400>  69

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  70
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of OKT3

<400>  70

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of OKT3

<400>  71

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of OKT3

<400>  72

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  73
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  73

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 20G6-F3

<400>  74

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 20G6-F3, 4B4-D7, and/or  4E7-C9

<400>  75

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 20G6-F3

<400>  76

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 20G6-F3

<400>  77

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 20G6-F3

<400>  78

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4B4-D7

<400>  79

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4B4-D7 and/or 4E7-C9

<400>  80

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4B4-D7

<400>  81

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4B4-D7

<400>  82

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4E7-C9

<400>  83

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4E7-C9

<400>  84

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  85
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4E7-C9

<400>  85

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 18F5-H10

<400>  86

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 18F5-H10

<400>  87

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 18F5-H10

<400>  88

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 18F5-H10

<400>  89

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  90
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 18F5-H10

<400>  90

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  91
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 variable heavy chain

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGN1412 variable light chain

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRL1

<400>  93

His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
1               5                   10      


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRL2

<400>  94

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRL3

<400>  95

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH1

<400>  96

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  97
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH2

<400>  97

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys 
1               5                   10                  


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH3

<400>  98

Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
1               5                   10      


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH1

<400>  99

Ser Tyr Tyr Ile His 
1               5   


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD28 CDRH2

<400>  100

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL1

<400>  101

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL2

<400>  102

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL3

<400>  103

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  104
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH1

<400>  104

Tyr Tyr Trp Ser 
1               


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH3

<400>  105

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL1

<400>  106

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL2

<400>  107

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRL3

<400>  108

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH1

<400>  109

Gly Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   10  


<210>  110
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH2

<400>  110

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
1               5                   10                  


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-4-1BB CDRH3

<400>  111

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of OKT8

<400>  112

Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala 
1               5                   10      


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of OKT8

<400>  113

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of OKT8

<400>  114

Gln Gln His Asn Glu Asn Pro Leu Thr 
1               5                   


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of OKT8

<400>  115

Gly Phe Asn Ile Lys Asp 
1               5       


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRLH2 of OKT8

<400>  116

Arg Ile Asp Pro Ala Asn Asp Asn Thr 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of OKT8

<400>  117

Gly Tyr Gly Tyr Tyr Val Phe Asp His 
1               5                   


<210>  118
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of KIR2DL1 and KIR2DL2/3

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  119
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of KIR2DL1 and KIR2DL2/3

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  120
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Any of residues 1 to 20 can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Entire sequence can be repeated n times wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10).

<400>  120

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser 
            20  


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  (GlyGlyGlyGlySer) can be repeated n times, wherein n is an 
       integer of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  121

Gly Gly Gly Gly Ser 
1               5   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  (GlyGlyGlyGlySer) can be repeated n times, wherein n is an 
       integer of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  122

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<220>
<221>  MISC_FEATURE
<222>  (5)..(7)
<223>  (GlyGlySer) can be repeated n times, wherein n is an integer of 
       1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  123

Gly Gly Gly Ser Gly Gly Ser 
1               5           


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

<400>  124

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  125
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  125

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  126

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  127

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  128

Gly Gly Gly Gly Ser 
1               5   


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  129

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  130
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  130

Gly Gly Gly Ser 
1               


<210>  131
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  131

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  132

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  133

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  134

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  135
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 4D nucleotides

<400>  135
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacagacttg acccacaggc ccaaaatcct catccctggc      480

actctagaac ccggccactc caaaaacctg acctgctctg tgtcctgggc ctgtgagcag      540

ggaacacccc cgatcttctc ctggttgtca gctgccccca cctccctggg ccccaggact      600

actcactcct cggtgctcat aatcacccca cggccccagg accacggcac caacctgacc      660

tgtcaggtga agttcgctgg agctggtgtg actacggaga gaaccatcca gctgaacgtc      720

acctatgttc cacagaaccc aacaactggt atctttccag gagatggctc agggaaacaa      780

gagaccagag caggagtggt tcatccggaa ccttccacgg ttcagatcct ccactcaccg      840

gctgtggagg gaagtcaagt cgagtttctt tgcatgtcac tggccaatcc tcttccaaca      900

aattacacgt ggtaccacaa tgggaaagaa atgcagggaa ggacagagga gaaagtccac      960

atcccaaaga tcctcccttg gcacgctggg acttattcct gtgtggcaga aaacattctt     1020

ggtactggac agaggggccc tggagctgag ctggatgtcc agtatcctcc caagaaggtg     1080

accacagtga ttcaaaaccc catgccgatt cgagaaggag acacagtgac cctttcctgt     1140

aactacaatt ccagtaaccc cagtgttacc cggtatgaat ggaaacccca tggcgcctgg     1200

gaggagccat cgcttggggt gctgaagatc caaaacgttg gctgggacaa cacaaccatc     1260

gcctgcgcag cttgtaatag ttggtgctcg tgggcctccc ctgtcgccct gaatgtccag     1320

tatgcccccc gagacgtgag ggtccggaaa atcaagcccc tttccgagat tcactctgga     1380

aactcggtca gcctccaatg tgacttctca agcagccacc ccaaagaagt ccagttcttc     1440

tgggagaaaa atggcaggct tctggggaaa gaaagccagc tgaattttga ctccatctcc     1500

ccagaagatg ctgggagtta cagctgctgg gtgaacaact ccataggaca gacagcgtcc     1560

aaggcctgga cacttgaagt gctgtatgca cccaggaggc tgcgtgtgtc catgagccca     1620

ggggaccaag tgatggaggg gaagagtgca accctgacct gtgagagcga cgccaaccct     1680

cccgtctccc actacacctg gtttgactgg aataaccaaa gcctccccta ccacagccag     1740

aagctgagat tggagccggt gaaggtccag cactcgggtg cctactggtg ccaggggacc     1800

aacagtgtgg gcaagggccg ttcgcctctc agcaccctca ccgtctacta tagcccggag     1860

accggggcca ttggaggagc tggtgttaca gccctgctcg ctctttgtct ctgcctcatc     1920

ttcttcatag tgaagaccca caggaggaaa gcagccagga cagcagtggg caggaatgac     1980

acccacccta ccacagggtc agcctccccg aaacaccaga agaagtccaa gttacatggc     2040

cccactgaaa cctcaagctg ttcaggtgcc gcccctactg tggagatgga tgaggagctg     2100

cattatgctt ccctcaactt tcatgggatg aatccttcca aggacacctc caccgaatac     2160

tcagaggtca ggacccag                                                   2178


<210>  136
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 2D protein

<400>  136

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly 
145                 150                 155                 160 


Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser Trp 
                165                 170                 175     


Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala Ala 
            180                 185                 190         


Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile Ile 
        195                 200                 205             


Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu Asn Val 
225                 230                 235                 240 


Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly Asp Gly 
                245                 250                 255     


Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Pro Arg Asp Val 
            260                 265                 270         


Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser 
        275                 280                 285             


Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln 
    290                 295                 300                 


Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu 
305                 310                 315                 320 


Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp 
                325                 330                 335     


Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu 
            340                 345                 350         


Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp 
        355                 360                 365             


Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala 
    370                 375                 380                 


Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser 
385                 390                 395                 400 


Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln 
                405                 410                 415     


His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly 
            420                 425                 430         


Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Gly 
        435                 440                 445             


Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys 
    450                 455                 460                 


Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr 
465                 470                 475                 480 


Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro 
                485                 490                 495     


Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser 
            500                 505                 510         


Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr 
        515                 520                 525             


Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr 
    530                 535                 540                 


Glu Tyr Ser Glu Val Arg Thr Gln 
545                 550         


<210>  137
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 2D nucleotides

<400>  137
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacagacttg acccacaggc ccaaaatcct catccctggc      480

actctagaac ccggccactc caaaaacctg acctgctctg tgtcctgggc ctgtgagcag      540

ggaacacccc cgatcttctc ctggttgtca gctgccccca cctccctggg ccccaggact      600

actcactcct cggtgctcat aatcacccca cggccccagg accacggcac caacctgacc      660

tgtcaggtga agttcgctgg agctggtgtg actacggaga gaaccatcca gctgaacgtc      720

acctatgttc cacagaaccc aacaactggt atctttccag gagatggctc agggaaacaa      780

gagaccagag caggagtggt tcatccccga gacgtgaggg tccggaaaat caagcccctt      840

tccgagattc actctggaaa ctcggtcagc ctccaatgtg acttctcaag cagccacccc      900

aaagaagtcc agttcttctg ggagaaaaat ggcaggcttc tggggaaaga aagccagctg      960

aattttgact ccatctcccc agaagatgct gggagttaca gctgctgggt gaacaactcc     1020

ataggacaga cagcgtccaa ggcctggaca cttgaagtgc tgtatgcacc caggaggctg     1080

cgtgtgtcca tgagcccagg ggaccaagtg atggagggga agagtgcaac cctgacctgt     1140

gagagcgacg ccaaccctcc cgtctcccac tacacctggt ttgactggaa taaccaaagc     1200

ctcccctacc acagccagaa gctgagattg gagccggtga aggtccagca ctcgggtgcc     1260

tactggtgcc aggggaccaa cagtgtgggc aagggccgtt cgcctctcag caccctcacc     1320

gtctactata gcccggagac cggggccatt ggaggagctg gtgttacagc cctgctcgct     1380

ctttgtctct gcctcatctt cttcatagtg aagacccaca ggaggaaagc agccaggaca     1440

gcagtgggca ggaatgacac ccaccctacc acagggtcag cctccccgaa acaccagaag     1500

aagtccaagt tacatggccc cactgaaacc tcaagctgtt caggtgccgc ccctactgtg     1560

gagatggatg aggagctgca ttatgcttcc ctcaactttc atgggatgaa tccttccaag     1620

gacacctcca ccgaatactc agaggtcagg acccag                               1656


<210>  138
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 V-set construct (exon 3 and 4 deleted) protein

<400>  138

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro 
145                 150                 155                 160 


Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Gly 
                165                 170                 175     


Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys 
            180                 185                 190         


Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr 
        195                 200                 205             


Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro 
    210                 215                 220                 


Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser 
225                 230                 235                 240 


Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr 
                245                 250                 255     


Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr 
            260                 265                 270         


Glu Tyr Ser Glu Val Arg Thr Gln 
        275                 280 


<210>  139
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 V-set construct (exon 3 and 4 deleted) nucleotides

<400>  139
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacatatgtt ccacagaacc caacaactgg tatctttcca      480

ggagatggct cagggaaaca agagaccaga gcaggagtgg ttcatggggc cattggagga      540

gctggtgtta cagccctgct cgctctttgt ctctgcctca tcttcttcat agtgaagacc      600

cacaggagga aagcagccag gacagcagtg ggcaggaatg acacccaccc taccacaggg      660

tcagcctccc cgaaacacca gaagaagtcc aagttacatg gccccactga aacctcaagc      720

tgttcaggtg ccgcccctac tgtggagatg gatgaggagc tgcattatgc ttccctcaac      780

tttcatggga tgaatccttc caaggacacc tccaccgaat actcagaggt caggacccag      840


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 signal peptide

<400>  140

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met 
    


<210>  141
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 signal peptide coding sequence

<400>  141
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat g                51


<210>  142
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  142

His His His His His His 
1               5       


<210>  143
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His tag coding sequence

<400>  143
catcatcacc accatcac                                                     18


<210>  144

<400>  144
000

<210>  145
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain

<400>  145

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  146
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain coding sequence

<400>  146
gatccaaatt tctggctgca agtgcaggag tcagtgacgg tacaggaggg tttgtgcgtc       60

ctcgtgccct gcactttctt ccatcccata ccctactacg acaagaactc cccagttcat      120

ggttactggt tccgggaagg agccattata tccagggact ctccagtggc cacaaacaag      180

ctagatcaag aagtacagga ggagactcag ggcagattcc gcctccttgg ggatcccagt      240

aggaacaact gctccctgag catcgtagac gccaggagga gggataatgg ttcatacttc      300

tttcggatgg agagaggaag taccaaatac agttacaaat ctccccagct ctctgtgcat      360

gtgacagact tgacccacag gcccaaaatc ctcatccctg gcactctaga acccggccac      420

tccaaaaacc tgacctgctc tgtgtcctgg gcctgtgagc agggaacacc cccgatcttc      480

tcctggttgt cagctgcccc cacctccctg ggccccagga ctactcactc ctcggtgctc      540

ataatcaccc cacggcccca ggaccacggc accaacctga cctgtcaggt gaagttcgct      600

ggagctggtg tgactacgga gagaaccatc cagctgaacg tcacctatgt tccacagaac      660

ccaacaactg gtatctttcc aggagatggc tcagggaaac aagagaccag agcaggagtg      720

gttcat                                                                 726


<210>  147
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain lacking CD33 amino acids 140-232

<400>  147

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Tyr Val Pro Gln Asn Pro 
        115                 120                 125             


Thr Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg 
    130                 135                 140                 


Ala Gly Val Val His 
145                 


<210>  148
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain lacking CD33 amino acids 140-232 coding
       sequence

<400>  148
gatccaaatt tctggctgca agtgcaggag tcagtgacgg tacaggaggg tttgtgcgtc       60

ctcgtgccct gcactttctt ccatcccata ccctactacg acaagaactc cccagttcat      120

ggttactggt tccgggaagg agccattata tccagggact ctccagtggc cacaaacaag      180

ctagatcaag aagtacagga ggagactcag ggcagattcc gcctccttgg ggatcccagt      240

aggaacaact gctccctgag catcgtagac gccaggagga gggataatgg ttcatacttc      300

tttcggatgg agagaggaag taccaaatac agttacaaat ctccccagct ctctgtgcat      360

gtgacatatg ttccacagaa cccaacaact ggtatctttc caggagatgg ctcagggaaa      420

caagagacca gagcaggagt ggttcat                                          447


<210>  149
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 transmembrane domain

<400>  149

Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Cys Leu Ile Phe Phe Ile Val 
            20              


<210>  150
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 transmembrane domain coding sequence

<400>  150
ggggccattg gaggagctgg tgttacagcc ctgctcgctc tttgtctctg cctcatcttc       60

ttcatagtg                                                               69


<210>  151
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 intracellular domain

<400>  151

Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp 
1               5                   10                  15      


Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser 
            20                  25                  30          


Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro 
        35                  40                  45              


Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His 
    50                  55                  60                  


Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg 
65                  70                  75                  80  


Thr Gln 
        


<210>  152
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 intracellular domain coding sequence

<400>  152
aagacccaca ggaggaaagc agccaggaca gcagtgggca ggaatgacac ccaccctacc       60

acagggtcag cctccccgaa acaccagaag aagtccaagt tacatggccc cactgaaacc      120

tcaagctgtt caggtgccgc ccctactgtg gagatggatg aggagctgca ttatgcttcc      180

ctcaactttc atgggatgaa tccttccaag gacacctcca ccgaatactc agaggtcagg      240

acccag                                                                 246


<210>  153
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 3, Ig-like C2-type 4, Ig-like C2-type 
       5, Ig-like C2-type 6

<400>  153

Pro Glu Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly 
1               5                   10                  15      


Ser Gln Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr 
            20                  25                  30          


Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu 
        35                  40                  45              


Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr 
    50                  55                  60                  


Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile 
                85                  90                  95      


Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys 
            100                 105                 110         


Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro 
        115                 120                 125             


His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn 
    130                 135                 140                 


Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp 
145                 150                 155                 160 


Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg 
                165                 170                 175     


Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly 
            180                 185                 190         


Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu 
        195                 200                 205             


Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser 
    210                 215                 220                 


Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser 
225                 230                 235                 240 


Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr 
                245                 250                 255     


Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro 
            260                 265                 270         


Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser 
        275                 280                 285             


Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn 
    290                 295                 300                 


Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys 
305                 310                 315                 320 


Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly 
                325                 330                 335     


Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu 
            340                 345                 350         


Thr 
    


<210>  154
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 3, Ig-like C2-type 4, Ig-like C2-type 
       5, Ig-like C2-type 6 coding sequence

<400>  154
ccggaacctt ccacggttca gatcctccac tcaccggctg tggagggaag tcaagtcgag       60

tttctttgca tgtcactggc caatcctctt ccaacaaatt acacgtggta ccacaatggg      120

aaagaaatgc agggaaggac agaggagaaa gtccacatcc caaagatcct cccttggcac      180

gctgggactt attcctgtgt ggcagaaaac attcttggta ctggacagag gggccctgga      240

gctgagctgg atgtccagta tcctcccaag aaggtgacca cagtgattca aaaccccatg      300

ccgattcgag aaggagacac agtgaccctt tcctgtaact acaattccag taaccccagt      360

gttacccggt atgaatggaa accccatggc gcctgggagg agccatcgct tggggtgctg      420

aagatccaaa acgttggctg ggacaacaca accatcgcct gcgcagcttg taatagttgg      480

tgctcgtggg cctcccctgt cgccctgaat gtccagtatg ccccccgaga cgtgagggtc      540

cggaaaatca agcccctttc cgagattcac tctggaaact cggtcagcct ccaatgtgac      600

ttctcaagca gccaccccaa agaagtccag ttcttctggg agaaaaatgg caggcttctg      660

gggaaagaaa gccagctgaa ttttgactcc atctccccag aagatgctgg gagttacagc      720

tgctgggtga acaactccat aggacagaca gcgtccaagg cctggacact tgaagtgctg      780

tatgcaccca ggaggctgcg tgtgtccatg agcccagggg accaagtgat ggaggggaag      840

agtgcaaccc tgacctgtga gagcgacgcc aaccctcccg tctcccacta cacctggttt      900

gactggaata accaaagcct cccctaccac agccagaagc tgagattgga gccggtgaag      960

gtccagcact cgggtgccta ctggtgccag gggaccaaca gtgtgggcaa gggccgttcg     1020

cctctcagca ccctcaccgt ctactatagc ccggagacc                            1059


<210>  155
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 5, Ig-like C2-type 6

<400>  155

Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
1               5                   10                  15      


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
            20                  25                  30          


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
        35                  40                  45              


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
    50                  55                  60                  


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
65                  70                  75                  80  


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
                85                  90                  95      


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
            100                 105                 110         


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
        115                 120                 125             


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
    130                 135                 140                 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
145                 150                 155                 160 


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
                165                 170                 175     


Pro Glu Thr 
            


<210>  156
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 5, Ig-like C2-type 6 coding sequence

<400>  156
ccccgagacg tgagggtccg gaaaatcaag cccctttccg agattcactc tggaaactcg       60

gtcagcctcc aatgtgactt ctcaagcagc caccccaaag aagtccagtt cttctgggag      120

aaaaatggca ggcttctggg gaaagaaagc cagctgaatt ttgactccat ctccccagaa      180

gatgctggga gttacagctg ctgggtgaac aactccatag gacagacagc gtccaaggcc      240

tggacacttg aagtgctgta tgcacccagg aggctgcgtg tgtccatgag cccaggggac      300

caagtgatgg aggggaagag tgcaaccctg acctgtgaga gcgacgccaa ccctcccgtc      360

tcccactaca cctggtttga ctggaataac caaagcctcc cctaccacag ccagaagctg      420

agattggagc cggtgaaggt ccagcactcg ggtgcctact ggtgccaggg gaccaacagt      480

gtgggcaagg gccgttcgcc tctcagcacc ctcaccgtct actatagccc ggagacc         537


<210>  157
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6/CD3 bispecific molecule

<400>  157

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Leu Gln Asp Tyr Ser Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
305                 310                 315                 320 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
            340                 345                 350         


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
        355                 360                 365             


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                405                 410                 415     


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
            420                 425                 430         


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
    450                 455                 460                 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
465                 470                 475                 480 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                485                 490                 495     


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu His His His His His His 
        515                 520 


<210>  158
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgK signal peptide

<400>  158

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of anti-CD3

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  162
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of anti-CD3

<400>  162

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H8

<400>  163

Arg Tyr Ala Thr Gln Pro Phe Ser 
1               5               


<210>  164
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H8

<400>  164

Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr Gly Met His 
1               5                   10              


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H8

<400>  165

Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr 
1               5                   10  


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H8

<400>  166

Ala Arg Asp Leu Asp Tyr Asp Ser Ser Gly Gly Asp Tyr 
1               5                   10              


<210>  167
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D3

<400>  167

Arg Ala Ser Gln Ser Gly Ser Ser Ser Phe Leu Ser 
1               5                   10          


<210>  168
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2D3

<400>  168

Tyr Gly Ala Ser Thr Arg Ala Thr 
1               5               


<210>  169
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D3

<400>  169

Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Ala Met Ser 
1               5                   10              


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D3

<400>  170

Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr 
1               5                   10  


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D3

<400>  171

Ala Lys Arg Thr Arg Tyr Phe Asn Gly Met Asp Val 
1               5                   10          


<210>  172
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2E3

<400>  172

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  173
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2E3

<400>  173

Tyr Gly Thr Ser Ser Arg Ala Thr 
1               5               


<210>  174
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2E3

<400>  174

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10              


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2E3

<400>  175

Val Ile Trp Tyr Gly Gly Ser Asn Lys Tyr 
1               5                   10  


<210>  176
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2E3

<400>  176

Ala Arg Asp Gly Thr Gly Glu Asn Tyr Tyr Tyr Tyr Val Met Asp Val 
1               5                   10                  15      


<210>  177
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H10

<400>  177

Gln Gly Ile Arg Ile Tyr 
1               5       


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H10

<400>  178

Gly Tyr Ile Phe Thr Ser Tyr Asp 
1               5               


<210>  179
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H10

<400>  179

Ile Asp Pro Ser Gly Gly Ser Thr 
1               5               


<210>  180
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1A9 and/or 1B9

<400>  180

Gln Asp Ile Arg Asn Asp 
1               5       


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1A9

<400>  181

Gly Phe Thr Phe Ser Ile Tyr Asp 
1               5               


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1A9

<400>  182

Ile Gly Thr Ala Gly Asp Thr 
1               5           


<210>  183
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1E6 and/or 1D2

<400>  183

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  184
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1E6 and/or 1D2

<400>  184

Gly Phe Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1E6 and/or 1B9

<400>  185

Ile Trp Tyr Asp Gly Ser His Asn 
1               5               


<210>  186
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1D2

<400>  186

Ile Trp Tyr Asp Gly Ser Gln Lys 
1               5               


<210>  187
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1B9

<400>  187

Gly Phe Ile Phe Ser Ser Tyr Asp 
1               5               


<210>  188
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H8

<400>  188

Gln Asn Ile Gly Gly Asn 
1               5       


<210>  189
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H8

<400>  189

Gly Phe Thr Phe Gly Ser Tyr Gly 
1               5               


<210>  190
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H8

<400>  190

Ile Trp Tyr Asp Gly Ser Asn Glu 
1               5               


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D3

<400>  191

Gln Ser Gly Ser Ser Ser Phe 
1               5           


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D3

<400>  192

Gly Phe Thr Phe Ser Ile Tyr Ala 
1               5               


<210>  193
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D3

<400>  193

Ile Ser Asp Ser Gly Gly Thr Thr 
1               5               


<210>  194
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2E3

<400>  194

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  195
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2E3

<400>  195

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2E3

<400>  196

Ile Trp Tyr Gly Gly Ser Asn Lys 
1               5               


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H10

<400>  197

Ser Tyr Asp Met His 
1               5   


<210>  198
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H10

<400>  198

Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H10

<400>  199

Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr 
1               5                   


<210>  200
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1A9

<400>  200

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1A9

<400>  201

Ile Tyr Asp Met His 
1               5   


<210>  202
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1A9

<400>  202

Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Ala Gly Ser Val Lys Gly 
1               5                   10                  15      


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1A9

<400>  203

Glu Tyr Ser Gly Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1E6

<400>  204

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1E6, 1D2,  and/or 1B9

<400>  205

Ser Tyr Asp Ile His 
1               5   


<210>  206
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1E6 and/or 1B9

<400>  206

Val Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1E6 and/or 1D2

<400>  207

Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr 
1               5                   


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H10 and/or 1D2

<400>  208

Ala Thr Ser Ser Leu Gln Ser 
1               5           


<210>  209
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1D2

<400>  209

Val Ile Trp Tyr Asp Gly Ser Gln Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1B9

<400>  210

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  211
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1B9

<400>  211

Asp Tyr Ser Gly Ser Tyr Phe Asp Tyr 
1               5                   


<210>  212
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H8

<400>  212

Val Ile Trp Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  213
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H8

<400>  213

Asp Leu Asp Tyr Asp Ser Ser Gly Gly Asp Tyr 
1               5                   10      


<210>  214
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D3

<400>  214

Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D3

<400>  215

Arg Thr Arg Tyr Phe Asn Gly Met Asp Val 
1               5                   10  


<210>  216
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2E3

<400>  216

Val Ile Trp Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  217
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2E3

<400>  217

Asp Gly Thr Gly Glu Asn Tyr Tyr Tyr Tyr Val Met Asp Val 
1               5                   10                  


<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H10

<400>  218

Gly Tyr Ile Phe Thr Ser Tyr 
1               5           


<210>  219
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H10

<400>  219

Asp Pro Ser Gly Gly Ser 
1               5       


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1A9 and/or 2D3

<400>  220

Gly Phe Thr Phe Ser Ile Tyr 
1               5           


<210>  221
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1A9

<400>  221

Gly Thr Ala Gly Asp 
1               5   


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1E6, 1D2,  and/or 2E3

<400>  222

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  223
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1E6 and/or 1B9

<400>  223

Trp Tyr Asp Gly Ser His 
1               5       


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1D2

<400>  224

Trp Tyr Asp Gly Ser Gln 
1               5       


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1B9

<400>  225

Gly Phe Ile Phe Ser Ser Tyr 
1               5           


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H8

<400>  226

Gly Phe Thr Phe Gly Ser Tyr 
1               5           


<210>  227
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H8

<400>  227

Trp Tyr Asp Gly Ser Asn 
1               5       


<210>  228
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D3

<400>  228

Ser Asp Ser Gly Gly Thr 
1               5       


<210>  229
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2E3

<400>  229

Trp Tyr Gly Gly Ser Asn 
1               5       


<210>  230
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 scFv VH-VL orientation

<400>  230

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Ile 
        35                  40                  45              


Phe Thr Ser Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr 
65                  70                  75                  80  


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Met 
                85                  90                  95      


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Arg Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Gly Ile Arg Ile Tyr Leu Gly Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Ser Leu Gln 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Leu Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys 
            260 


<210>  231
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 scFv VL-VH orientation

<400>  231

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Ile Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Val Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Ser Tyr Asp Met 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile 
            180                 185                 190         


Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly 
        195                 200                 205             


Arg Val Thr Met Thr Arg Asp Thr Ser Met Ser Thr Val Tyr Met Glu 
    210                 215                 220                 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
225                 230                 235                 240 


Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  232
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 scFv VH-VL orientation

<400>  232

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Ala 
65                  70                  75                  80  


Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Tyr Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Ile Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln Glu Tyr Asn Tyr Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys 
            


<210>  233
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 scFv VL-VH orientation

<400>  233

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Ile Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Tyr 
            100                 105                 110         


Asn Tyr Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Asp Met 
                165                 170                 175     


His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val Ser Ala 
            180                 185                 190         


Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Ala Gly Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
225                 230                 235                 240 


Tyr Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  234
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 scFv VH-VL orientation

<400>  234

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Leu Gln Asp Tyr Ser Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys 
            260 


<210>  235
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 scFv VL-VH orientation

<400>  235

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Ser Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
            180                 185                 190         


Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  236
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 scFv VH-VL orientation

<400>  236

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ile Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Lys Arg Thr Arg Tyr Phe Asn Gly Met Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Gly Ser Ser Ser Phe Leu Ser Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr 
        195                 200                 205             


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro Phe Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Asp Ile Lys 
            260         


<210>  237
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 scFv VL-VH orientation

<400>  237

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Gly Ser Ser Ser Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp 
            100                 105                 110         


Tyr Asn Leu Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Ala 
                165                 170                 175     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            180                 185                 190         


Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr Leu 
    210                 215                 220                 


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys Arg Thr Arg Tyr Phe Asn Gly Met Asp Val Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Val Thr Val Ser Ser 
            260         


<210>  238
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 scFv /CD3 bispecific antibody

<400>  238

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Ile 
        35                  40                  45              


Phe Thr Ser Tyr Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Ile Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr 
65                  70                  75                  80  


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Met 
                85                  90                  95      


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Arg Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Gly Ile Arg Ile Tyr Leu Gly Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Ser Leu Gln 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Leu Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
305                 310                 315                 320 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
            340                 345                 350         


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
        355                 360                 365             


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                405                 410                 415     


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
            420                 425                 430         


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
    450                 455                 460                 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
465                 470                 475                 480 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                485                 490                 495     


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu His His His His His His 
        515                 520 


<210>  239
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 scFv /CD3 bispecific antibody

<400>  239

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Ile Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Val Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Ser Tyr Asp Met 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile 
            180                 185                 190         


Ile Asp Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly 
        195                 200                 205             


Arg Val Thr Met Thr Arg Asp Thr Ser Met Ser Thr Val Tyr Met Glu 
    210                 215                 220                 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
225                 230                 235                 240 


Asp Tyr Ser Trp Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
305                 310                 315                 320 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
            340                 345                 350         


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
        355                 360                 365             


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                405                 410                 415     


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
            420                 425                 430         


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
    450                 455                 460                 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
465                 470                 475                 480 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                485                 490                 495     


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu His His His His His His 
        515                 520 


<210>  240
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 scFv/CD3 bispecific antibody

<400>  240

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Ala 
65                  70                  75                  80  


Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Tyr Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Ile Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln Glu Tyr Asn Tyr Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
305                 310                 315                 320 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
            340                 345                 350         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
        355                 360                 365             


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                405                 410                 415     


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
            420                 425                 430         


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
465                 470                 475                 480 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                485                 490                 495     


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            500                 505                 510         


Leu His His His His His His 
        515                 


<210>  241
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 scFv/CD3 bispecific antibody

<400>  241

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Ile Leu Ile Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Glu Tyr 
            100                 105                 110         


Asn Tyr Pro Cys Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Asp Met 
                165                 170                 175     


His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val Ser Ala 
            180                 185                 190         


Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Ala Gly Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 
225                 230                 235                 240 


Tyr Ser Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
305                 310                 315                 320 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
            340                 345                 350         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
        355                 360                 365             


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                405                 410                 415     


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
            420                 425                 430         


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
465                 470                 475                 480 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                485                 490                 495     


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            500                 505                 510         


Leu His His His His His His 
        515                 


<210>  242
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 scFv/CD3 bispecific antibody

<400>  242

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Leu Gln Asp Tyr Ser Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
305                 310                 315                 320 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
            340                 345                 350         


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
        355                 360                 365             


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                405                 410                 415     


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
            420                 425                 430         


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
    450                 455                 460                 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
465                 470                 475                 480 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                485                 490                 495     


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu His His His His His His 
        515                 520 


<210>  243
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 scFv/CD3 bispecific antibody

<400>  243

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Ser Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val 
            180                 185                 190         


Ile Trp Tyr Asp Gly Ser His Asn Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
305                 310                 315                 320 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
            340                 345                 350         


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
        355                 360                 365             


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
                405                 410                 415     


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
            420                 425                 430         


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
        435                 440                 445             


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
    450                 455                 460                 


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
465                 470                 475                 480 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
                485                 490                 495     


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            500                 505                 510         


Val Leu His His His His His His 
        515                 520 


<210>  244
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 scFv/CD3 bispecific antibody

<400>  244

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ile Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Lys Arg Thr Arg Tyr Phe Asn Gly Met Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Gly Ser Ser Ser Phe Leu Ser Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr 
        195                 200                 205             


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro Phe Thr Phe Gly Pro Gly 
                245                 250                 255     


Thr Lys Val Asp Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
305                 310                 315                 320 


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
                325                 330                 335     


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
            340                 345                 350         


Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
        355                 360                 365             


Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                405                 410                 415     


Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
            420                 425                 430         


Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
        435                 440                 445             


Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala 
    450                 455                 460                 


Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
465                 470                 475                 480 


Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                485                 490                 495     


Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
            500                 505                 510         


Leu Thr Val Leu His His His His His His 
        515                 520         


<210>  245
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 scFv/CD3 bispecific antibody

<400>  245

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Gly Ser Ser Ser Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp 
            100                 105                 110         


Tyr Asn Leu Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr Ala 
                165                 170                 175     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            180                 185                 190         


Ala Ile Ser Asp Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr Leu 
    210                 215                 220                 


Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys Arg Thr Arg Tyr Phe Asn Gly Met Asp Val Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
305                 310                 315                 320 


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
                325                 330                 335     


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
            340                 345                 350         


Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
        355                 360                 365             


Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
                405                 410                 415     


Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
            420                 425                 430         


Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
        435                 440                 445             


Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala 
    450                 455                 460                 


Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
465                 470                 475                 480 


Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
                485                 490                 495     


Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
            500                 505                 510         


Leu Thr Val Leu His His His His His His 
        515                 520         


<210>  246
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  246
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggctat ggatccaaat       60

ttctggctgc aagtgcagga gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc      120

tgcactttct tccatcccat accctactac gacaagaact ccccagttca tggttactgg      180

ttccgggaag gagccattat atccagggac tctccagtgg ccacaaacaa gctagatcaa      240

gaagtacagg aggagactca gggcagattc cgcctccttg gggatcccag taggaacaac      300

tgctccctga gcatcgtaga cgccaggagg agggataatg gttcatactt ctttcggatg      360

gagagaggaa gtaccaaata cagttacaaa tctccccagc tctctgtgca tgtgacagac      420

ttgacccaca ggcccaaaat cctcatccct ggcactctag aacccggcca ctccaaaaac      480

ctgacctgct ctgtgtcctg ggcctgtgag cagggaacac ccccgatctt ctcctggttg      540

tcagctgccc ccacctccct gggccccagg actactcact cctcggtgct cataatcacc      600

ccacggcccc aggaccacgg caccaacctg acctgtcagg tgaagttcgc tggagctggt      660

gtgactacgg agagaaccat ccagctcaac gtcacctatg ttccacagaa cccaacaact      720

ggtatctttc caggagatgg ctcagggaaa caagagacca gagcaggagt ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cccacaggag gaaagcagcc aggacagcag tgggcaggaa tgacacccac      900

cctaccacag ggtcagcctc cccgaaacac cagaagaagt ccaagttaca tggccccact      960

gaaacctcaa gctgttcagg tgccgcccct actgtggaga tggatgagga gctgcattat     1020

gcttccctca actttcatgg gatgaatcct tccaaggaca cctccaccga atactcagag     1080

gtcaggaccc ag                                                         1092


<210>  247
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  248
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10, 1A9, 1E6, and/or 1B9 light chain signal peptide

<400>  248

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  249
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D2 light chain signal peptide

<400>  249

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys 
            20  


<210>  250
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H8 light chain signal peptide

<400>  250

Met Asp Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp 
1               5                   10                  15      


Val Pro Ala Ser Arg Gly 
            20          


<210>  251
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 light chain signal peptide

<400>  251

Met Glu Pro Trp Lys Pro Gln His Ser Phe Phe Phe Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Asp Ser Thr Gly 
            20          


<210>  252
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H10 heavy chain signal peptide

<400>  252

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  253
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A9 heavy chain signal peptide

<400>  253

Met Glu Leu Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  254
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E6 and/or 2E3 heavy chain signal peptide

<400>  254

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  255
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D2 heavy chain signal peptide

<400>  255

Met Glu Ser Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  256
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B9 heavy chain signal peptide

<400>  256

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Ile Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  257
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H8 heavy chain signal peptide

<400>  257

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  258
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D3 heavy chain signal peptide

<400>  258

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  259
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-set directed CD33/CD3 BsAb (RC1)

<400>  259

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
            20                  25                  30          


Lys Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
65                  70                  75                  80  


Ala Asp Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ser Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr 
                165                 170                 175     


Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn 
            180                 185                 190         


Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        195                 200                 205             


Leu Leu Leu Ser Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser 
225                 230                 235                 240 


Pro Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His 
                245                 250                 255     


Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    290                 295                 300                 


Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
            340                 345                 350         


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr 
    370                 375                 380                 


Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
            420                 425                 430         


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
        435                 440                 445             


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
    450                 455                 460                 


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
                485                 490                 495     


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
            500                 505                 510         


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu His His His 
        515                 520                 525             


His His His 
    530     


<210>  260
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V-set directed CD33/CD3 BsAb (RC1) without leader sequence or His
       tag

<400>  260

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505 


