                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Icahn School of Medicine at Mount Sinai
       Pardi, Norbert
       Nachbagauer, Raffael
       Palese, Peter
       Weissman, Drew
       Krammer, Florian
       Garcia-Sastre, Adolfo
       Freyn, Alec W
 
<120>  Universal Influenza Vaccine Using Nucleoside-Modified mRNA

<130>  046483-6188-00WO

<150>  US 63/002,682
<151>  2020-03-31

<160>  133   

<170>  PatentIn version 3.5

<210>  1
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - HA antigen Amino Acid sequence

<400>  1

Met Glu Ala Arg Leu Leu Val Leu Leu Cys Ala Phe Ala Ala Thr Asn 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Leu Leu Leu Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Lys Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Glu 
    130                 135                 140                 


Thr Thr Lys Gly Val Thr Ala Ala Cys Ser Tyr Ala Gly Ala Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Ser Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Pro Thr Gly Thr Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Ser Val Gly Ser Ser Lys Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Ala Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe 
            260                 265                 270         


Ala Leu Asn Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Ala Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Lys Cys Gln Thr Pro His Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn 
                405                 410                 415     


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Arg Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asp Ala Cys Met Glu Ser Val 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  2
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  2
atggaggccc gcctgctggt gctgctgtgc gccttcgccg ccaccaacgc cgacaccatc       60

tgcatcggct accacgccaa caactccacc gacaccgtgg acaccgtgct ggagaagaac      120

gtgaccgtga cccactccgt gaacctgctg gaggactccc acaacggcaa gctgtgcaag      180

ctgaagggca tcgcccccct gcagctgggc aagtgcaaca tcgccggctg gctgctgggc      240

aaccccgagt gcgacctgct gctgaccgcc tcctcctggt cctacatcgt ggagacctcc      300

aactccgaga acggcacctg ctaccccggc gacttcatcg actacgagga gctgcgcgag      360

cagctgtcct ccgtgtcctc cttcgagaag ttcgagatct tccccaagac ctcctcctgg      420

cccaaccacg agaccaccaa gggcgtgacc gccgcctgct cctacgccgg cgcctcctcc      480

ttctaccgca acctgctgtg gctgaccaag aagggctcct cctaccccaa gctgtccaag      540

tcctacgtga acaacaaggg caaggaggtg ctggtgctgt ggggcgtgca ccaccccccc      600

accggcaccg accagcagtc cctgtaccag aacgccgacg cctacgtgtc cgtgggctcc      660

tccaagtaca accgccgctt cacccccgag atcgccgccc gccccaaggt gcgcgaccag      720

gccggccgca tgaactacta ctggaccctg ctggagcccg gcgacaccat caccttcgag      780

gccaccggca acctgatcgc cccctggtac gccttcgccc tgaaccgcgg ctccggctcc      840

ggcatcatca cctccgacgc ccccgtgcac gactgcaaca ccaagtgcca gaccccccac      900

ggcgccatca actcctccct gcccttccag aacatccacc ccgtgaccat cggcgagtgc      960

cccaagtacg tgcgctccac caagctgcgc atggccaccg gcctgcgcaa catcccctcc     1020

atccagtccc gcggcctgtt cggcgccatc gccggcttca tcgagggcgg ctggaccggc     1080

atgatcgacg gctggtacgg ctaccaccac cagaacgagc agggctccgg ctacgccgcc     1140

gaccagaagt ccacccagaa cgccatcgac ggcatcacca acaaggtgaa ctccgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaggagt tcaacaacct ggagcgccgc     1260

atcgagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tgctgctgga gaacgagcgc accctggact tccacgactc caacgtgcgc     1380

aacctgtacg agaaggtgaa gtcccagctg aagaacaacg ccaaggagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacgac gcctgcatgg agtccgtgcg caacggcacc     1500

tacgactacc ccaagtactc cgaggagtcc aagctgaacc gcgaggagat cgacggcgtg     1560

aagctggagt ccatgggcgt gtaccagatc ctggccatct actccaccgt ggcctcctcc     1620

ctggtgctgc tggtgtccct gggcgccatc tccttctgga tgtgctccaa cggctccctg     1680

cagtgccgca tctgcatc                                                   1698


<210>  3
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - HA antigen Amino Acid sequence

<400>  3

Met Ala Ile Thr Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Asp 
1               5                   10                  15      


Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Lys Val Asp 
            20                  25                  30          


Thr Ile Leu Glu Arg Asn Val Thr Val Thr His Ala Lys Asp Ile Leu 
        35                  40                  45              


Glu Lys Thr His Asn Gly Lys Leu Cys Lys Leu Asn Gly Ile Pro Pro 
    50                  55                  60                  


Leu Glu Leu Gly Asp Cys Ser Ile Ala Gly Trp Leu Leu Gly Asn Pro 
65                  70                  75                  80  


Glu Cys Asp Arg Phe Leu Arg Val Pro Glu Trp Ser Tyr Ile Met Glu 
                85                  90                  95      


Lys Glu Asn Pro Arg Tyr Ser Leu Cys Tyr Pro Gly Ser Phe Asn Asp 
            100                 105                 110         


Tyr Glu Glu Leu Lys His Leu Leu Ser Ser Val Lys His Phe Glu Lys 
        115                 120                 125             


Val Lys Ile Leu Pro Lys Asp Gly Trp Thr Gln His Thr Thr Thr Gly 
    130                 135                 140                 


Gly Ser Met Ala Cys Ala Val Ser Gly Lys Pro Ser Phe Phe Arg Asn 
145                 150                 155                 160 


Met Val Trp Leu Thr Glu Lys Gly Gln Asn Tyr Pro Val Ala Lys Gly 
                165                 170                 175     


Ser Tyr Asn Asn Thr Ser Gly Glu Gln Met Leu Ile Ile Trp Gly Val 
            180                 185                 190         


His His Pro Asn Asp Glu Ala Glu Gln Arg Ala Leu Tyr Gln Lys Val 
        195                 200                 205             


Gly Thr Tyr Val Ser Ala Ser Thr Ser Thr Leu Asn Lys Arg Ser Thr 
    210                 215                 220                 


Pro Glu Ile Ala Ala Arg Pro Lys Val Asn Gly Leu Gly Ser Arg Met 
225                 230                 235                 240 


Glu Phe Ser Trp Thr Leu Leu Asp Met Trp Asp Thr Ile Asn Phe Glu 
                245                 250                 255     


Ser Thr Gly Asn Leu Val Ala Pro Glu Tyr Gly Phe Lys Ile Ser Lys 
            260                 265                 270         


Arg Gly Ser Ser Gly Ile Met Lys Thr Glu Gly Thr Leu Glu Asn Cys 
        275                 280                 285             


Glu Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Thr Thr Leu Pro 
    290                 295                 300                 


Phe His Asn Val His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val 
305                 310                 315                 320 


Lys Ser Glu Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Ile Pro Gln 
                325                 330                 335     


Ile Glu Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
            340                 345                 350         


Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn 
        355                 360                 365             


Asp Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala 
    370                 375                 380                 


Phe Asp Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn 
385                 390                 395                 400 


Thr Gln Phe Glu Ala Val Gly Lys Glu Phe Ser Asn Leu Glu Lys Arg 
                405                 410                 415     


Leu Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp 
            420                 425                 430         


Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu 
        435                 440                 445             


Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Met 
    450                 455                 460                 


Gln Leu Arg Asp Asn Val Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe 
465                 470                 475                 480 


Tyr His Lys Cys Asp Asn Glu Cys Met Asp Ser Val Lys Asn Gly Thr 
                485                 490                 495     


Tyr Asp Tyr Pro Lys Tyr Glu Glu Glu Ser Lys Leu Asn Arg Asn Glu 
            500                 505                 510         


Ile Lys Gly Val Lys Leu Ser Ser Met Gly Val Tyr Gln Ile Leu Ala 
        515                 520                 525             


Ile Tyr Ala Thr Val Ala Gly Ser Leu Ser Leu Ala Ile Met Met Ala 
    530                 535                 540                 


Gly Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
545                 550                 555                 560 


Cys Ile 
        


<210>  4
<211>  1686
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  4
atggccatca cctacctgat cctgctgttc accgccgtgc gcggcgacca gatctgcatc       60

ggctaccacg ccaacaactc caccgagaag gtggacacca tcctggagcg caacgtgacc      120

gtgacccacg ccaaggacat cctggagaag acccacaacg gcaagctgtg caagctgaac      180

ggcatccccc ccctggagct gggcgactgc tccatcgccg gctggctgct gggcaacccc      240

gagtgcgacc gcttcctgcg cgtgcccgag tggtcctaca tcatggagaa ggagaacccc      300

cgctactccc tgtgctaccc cggctccttc aacgactacg aggagctgaa gcacctgctg      360

tcctccgtga agcacttcga gaaggtgaag atcctgccca aggacggctg gacccagcac      420

accaccaccg gcggctccat ggcctgcgcc gtgtccggca agccctcctt cttccgcaac      480

atggtgtggc tgaccgagaa gggccagaac taccccgtgg ccaagggctc ctacaacaac      540

acctccggcg agcagatgct gatcatctgg ggcgtgcacc accccaacga cgaggccgag      600

cagcgcgccc tgtaccagaa ggtgggcacc tacgtgtccg cctccacctc caccctgaac      660

aagcgctcca cccccgagat cgccgcccgc cccaaggtga acggcctggg ctcccgcatg      720

gagttctcct ggaccctgct ggacatgtgg gacaccatca acttcgagtc caccggcaac      780

ctggtggccc ccgagtacgg cttcaagatc tccaagcgcg gctcctccgg catcatgaag      840

accgagggca ccctggagaa ctgcgagacc aagtgccaga cccccctggg cgccatcaac      900

accaccctgc ccttccacaa cgtgcacccc ctgaccatcg gcgagtgccc caagtacgtg      960

aagtccgaga agctggtgct ggccaccggc ctgcgcaaca tcccccagat cgagtcccgc     1020

ggcctgttcg gcgccatcgc cggcttcatc gagggcggct ggcagggcat ggtggacggc     1080

tggtacggct accaccactc caacgaccag ggctccggct acgccgccga caaggagtcc     1140

acccagaagg ccttcgacgg catcaccaac aaggtgaact ccgtgatcga gaagatgaac     1200

acccagttcg aggccgtggg caaggagttc tccaacctgg agaagcgcct ggagaacctg     1260

aacaagaaga tggaggacgg cttcctggac gtgtggacct acaacgccga gctgctggtg     1320

ctgatggaga acgagcgcac cctggacttc cacgactcca acgtgaagaa cctgtacgac     1380

aaggtgcgca tgcagctgcg cgacaacgtg aaggagctgg gcaacggctg cttcgagttc     1440

taccacaagt gcgacaacga gtgcatggac tccgtgaaga acggcaccta cgactacccc     1500

aagtacgagg aggagtccaa gctgaaccgc aacgagatca agggcgtgaa gctgtcctcc     1560

atgggcgtgt accagatcct ggccatctac gccaccgtgg ccggctccct gtccctggcc     1620

atcatgatgg ccggcatctc cttctggatg tgctccaacg gctccctgca gtgccgcatc     1680

tgcatc                                                                1686


<210>  5
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - HA antigen Amino Acid sequence

<400>  5

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Phe Cys Leu Ala Leu Gly 
1               5                   10                  15      


Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asp Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Val Phe Gln 
                85                  90                  95      


Asn Glu Thr Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr Glu Gly Phe Thr Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Gly Ser Asn Ala Cys Lys Arg Gly Pro Gly 
145                 150                 155                 160 


Ser Gly Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Thr 
                165                 170                 175     


Tyr Pro Val Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asn Gln Glu Gln Thr 
        195                 200                 205             


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Arg Arg 
    210                 215                 220                 


Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
225                 230                 235                 240 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Val Leu Val Ile Asn Ser Asn Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Arg Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  6
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  6
atgaagacca tcatcgccct gtcctacatc ttctgcctgg ccctgggcca ggacctgccc       60

ggcaacgaca actccaccgc caccctgtgc ctgggccacc acgccgtgcc caacggcacc      120

ctggtgaaga ccatcaccga cgaccagatc gaggtgacca acgccaccga gctggtgcag      180

tcctcctcca ccggcaagat ctgcaacaac ccccaccgca tcctggacgg catcgactgc      240

accctgatcg acgccctgct gggcgacccc cactgcgacg tgttccagaa cgagacctgg      300

gacctgttcg tggagcgctc caaggccttc tccaactgct acccctacga cgtgcccgac      360

tacgcctccc tgcgctccct ggtggcctcc tccggcaccc tggagttcat caccgagggc      420

ttcacctgga ccggcgtgac ccagaacggc ggctccaacg cctgcaagcg cggccccggc      480

tccggcttct tctcccgcct gaactggctg accaagtccg gctccaccta ccccgtgctg      540

aacgtgacca tgcccaacaa cgacaacttc gacaagctgt acatctgggg cgtgcaccac      600

ccctccacca accaggagca gacctccctg tacgtgcagg cctccggccg cgtgaccgtg      660

tccacccgcc gctcccagca gaccatcatc cccaacatcg gctcccgccc ctgggtgcgc      720

ggcctgtcct cccgcatctc catctactgg accatcgtga agcccggcga cgtgctggtg      780

atcaactcca acggcaacct gatcgccccc cgcggctact tcaagatgcg caccggcaag      840

tcctccatca tgcgctccga cgcccccatc gacacctgca tctccgagtg catcaccccc      900

aacggctcca tccccaacga caagcccttc cagaacgtga acaagatcac ctacggcgcc      960

tgccccaagt acgtgaagca gaacaccctg aagctggcca ccggcatgcg caacgtgccc     1020

gagaagcaga cccgcggcct gttcggcgcc atcgccggct tcatcgagaa cggctgggag     1080

ggcatgatcg acggctggta cggcttccgc caccagaact ccgagggcac cggccaggcc     1140

gccgacctga agtccaccca ggccgccatc gaccagatca acggcaagct gaaccgcgtg     1200

atcgagaaga ccaacgagaa gttccaccag atcgagaagg agttctccga ggtggagggc     1260

cgcatccagg acctggagaa gtacgtggag gacaccaaga tcgacctgtg gtcctacaac     1320

gccgagctgc tggtggccct ggagaaccag cacaccatcg acctgaccga ctccgagatg     1380

aacaagctgt tcgagaagac ccgccgccag ctgcgcgaga acgccgagga catgggcaac     1440

ggctgcttca agatctacca caagtgcgac aacgcctgca tcgagtccat ccgcaacggc     1500

acctacgacc acgacgtgta ccgcgacgag gccctgaaca accgcttcca gatcaagggc     1560

gtggagctga agtccggcta caaggactgg atcctgtgga tctccttcgc catctcctgc     1620

ttcctgctgt gcgtggtgct gctgggcttc atcatgtggg cctgccagcg cggcaacatc     1680

cgctgcaaca tctgcatc                                                   1698


<210>  7
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - HA antigen Amino Acid sequence

<400>  7

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Ala Leu Ser Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Phe Ser Lys Lys Ser Trp Ser Tyr Ile 
                85                  90                  95      


Ala Glu Thr Pro Asn Ser Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Arg Ser Trp Pro Lys His Asn 
    130                 135                 140                 


Val Thr Arg Gly Val Thr Ala Ser Cys Ser His Lys Gly Lys Ser Ser 
145                 150                 155                 160 


Phe Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Asn Gly Ser Tyr Pro 
                165                 170                 175     


Asn Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Val His His Pro Ser Asn Ile Glu Asp Gln Lys Thr Ile 
        195                 200                 205             


Tyr Arg Lys Glu Asn Ala Tyr Val Ser Val Val Ser Ser Asn Tyr Asn 
    210                 215                 220                 


Arg Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Ala Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr 
                245                 250                 255     


Ile Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp His Ala Phe 
            260                 265                 270         


Ala Leu Asn Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser 
        275                 280                 285             


Met Asp Glu Cys Asp Thr Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys 
                405                 410                 415     


Leu Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  8
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  8
atgaaggcca agctgctggt gctgctgtgc gccctgtccg ccaccgacgc cgacaccatc       60

tgcatcggct accacgccaa caactccacc gacaccgtgg acaccgtgct ggagaagaac      120

gtgaccgtga cccactccgt gaacctgctg gaggactccc acaacggcaa gctgtgccgc      180

ctgaagggca tcgcccccct gcagctgggc aagtgcaaca tcgccggctg gatcctgggc      240

aaccccgagt gcgagtccct gttctccaag aagtcctggt cctacatcgc cgagaccccc      300

aactccgaga acggcacctg ctaccccggc tacttcgccg actacgagga gctgcgcgag      360

cagctgtcct ccgtgtcctc cttcgagcgc ttcgagatct tccccaagga gcgctcctgg      420

cccaagcaca acgtgacccg cggcgtgacc gcctcctgct cccacaaggg caagtcctcc      480

ttctaccgca acctgctgtg gctgaccgag aagaacggct cctaccccaa cctgtccaag      540

tcctacgtga acaacaagga gaaggaggtg ctggtgctgt ggggcgtgca ccacccctcc      600

aacatcgagg accagaagac catctaccgc aaggagaacg cctacgtgtc cgtggtgtcc      660

tccaactaca accgccgctt cacccccgag atcgccgagc gccccaaggt gcgcggccag      720

gccggccgca tcaactacta ctggaccctg ctggagcccg gcgacaccat catcttcgag      780

gccaacggca acctgatcgc cccctggcac gccttcgccc tgaaccgcgg cttcggctcc      840

ggcatcatca cctccaacgc ctccatggac gagtgcgaca ccaagtgcca gaccccccag      900

ggcgccatca actcctccct gcccttccag aacatccacc ccgtgaccat cggcgagtgc      960

cccaagtacg tgcgctccac caagctgcgc atggtgaccg gcctgcgcaa catcccctcc     1020

atccagtccc gcggcctgtt cggcgccatc gccggcttca tcgagggcgg ctggaccggc     1080

atgatcgacg gctggtacgg ctaccaccac cagaacgagc agggctccgg ctacgccgcc     1140

gaccagaagt ccacccagaa cgccatcaac ggcatcacca acaaggtgaa ctccgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaggagt tcaacaagct ggagaagcgc     1260

atggagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tgctgctgga gaacgagcgc accctggact tccacgactc caacgtgaag     1380

aacctgtacg agaaggtgaa gtcccagctg aagaacaacg ccaaggagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcaacaac gagtgcatgg agtccgtgaa gaacggcacc     1500

tacgactacc ccaagtactc cgaggagtcc aagctgaacc gcgagaagat cgacggcgtg     1560

aagctggagt ccatgggcgt gtaccagatc ctggccatct actccaccgt ggcctcctcc     1620

ctggtgctgc tggtgtccct gggcgccatc tccttctgga tgtgctccaa cggctccctg     1680

cagtgccgca tctgcatc                                                   1698


<210>  9
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - HA antigen Amino Acid sequence

<400>  9

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Val Gln Lys Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Lys Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  10
<211>  1695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  10
atgaaggtga agctgctggt gctgctgtgc accttcaccg ccacctacgc cgacaccatc       60

tgcatcggct accacgccaa caactccacc gacaccgtgg acaccgtgct ggagaagaac      120

gtgaccgtga cccactccgt gaacctgctg gagaactccc acaacggcaa gctgtgcctg      180

ctgaagggca tcgcccccct gcagctgggc aactgctccg tggccggctg gatcctgggc      240

aaccccgagt gcgagctgct gatctccaag gagtcctggt cctacatcgt ggagaagccc      300

aaccccgaga acggcacctg ctaccccggc cacttcgccg actacgagga gctgcgcgag      360

cagctgtcct ccgtgtcctc cttcgagcgc ttcgagatct tccccaagga gtcctcctgg      420

cccaaccaca ccgtgaccgg cgtgtccgcc tcctgctccc acaacggcga gtcctccttc      480

taccgcaacc tgctgtggct gaccggcaag aacggcctgt accccaacct gtccaagtcc      540

tacgccaaca acaaggagaa ggaggtgctg gtgctgtggg gcgtgcacca cccccccaac      600

atcggcgtgc agaaggccct gtaccacacc gagaacgcct acgtgtccgt ggtgtcctcc      660

cactactccc gcaagttcac ccccgagatc gccaagcgcc ccaaggtgcg cgaccaggag      720

ggccgcatca actactactg gaccctgctg gagcccggcg acaccatcat cttcgaggcc      780

aacggcaacc tgatcgcccc ccgctacgcc ttcgccctgt cccgcggctt cggctccggc      840

atcatcaact ccaacgcccc catggacaag tgcgacgcca agtgccagac cccccagggc      900

gccatcaact cctccctgcc cttccagaac gtgcaccccg tgaccatcgg cgagtgcccc      960

aagtacgtgc gctccgccaa gctgcgcatg gtgaccggcc tgcgcaacat cccctccatc     1020

cagtcccgcg gcctgttcgg cgccatcgcc ggcttcatcg agggcggctg gaccggcatg     1080

gtggacggct ggtacggcta ccaccaccag aacgagcagg gctccggcta cgccgccgac     1140

cagaagtcca cccagaacgc catcaacggc atcaccaaca aggtgaactc cgtgatcgag     1200

aagatgaaca cccagttcac cgccgtgggc aaggagttca acaagctgga gcgccgcatg     1260

gagaacctga acaagaaggt ggacgacggc ttcatcgaca tctggaccta caacgccgag     1320

ctgctggtgc tgctggagaa cgagcgcacc ctggacttcc acgactccaa cgtgaagaac     1380

ctgtacgaga aggtgaagtc ccagctgaag aacaacgcca aggagatcgg caacggctgc     1440

ttcgagttct accacaagtg caacgacgag tgcatggagt ccgtgaagaa cggcacctac     1500

gactacccca agtactccga ggagtccaag ctgaaccgcg agaagatcga cggcgtgaag     1560

ctggagtcca tgggcgtgta ccagatcctg gccatctact ccaccgtggc ctcctccctg     1620

gtgctgctgg tgtccctggg cgccatctcc ttctggatgt gctccaacgg ctccctgcag     1680

tgccgcatct gcatc                                                      1695


<210>  11
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - HA antigen Amino Acid sequence

<400>  11

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  12
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  12
atgaaggcca tcctggtggt gctgctgtac accttcgcca ccgccaacgc cgacaccctg       60

tgcatcggct accacgccaa caactccacc gacaccgtgg acaccgtgct ggagaagaac      120

gtgaccgtga cccactccgt gaacctgctg gaggacaagc acaacggcaa gctgtgcaag      180

ctgcgcggcg tggcccccct gcacctgggc aagtgcaaca tcgccggctg gatcctgggc      240

aaccccgagt gcgagtccct gtccaccgcc tcctcctggt cctacatcgt ggagaccccc      300

tcctccgaca acggcacctg ctaccccggc gacttcatcg actacgagga gctgcgcgag      360

cagctgtcct ccgtgtcctc cttcgagcgc ttcgagatct tccccaagac ctcctcctgg      420

cccaaccacg actccaacaa gggcgtgacc gccgcctgcc cccacgccgg cgccaagtcc      480

ttctacaaga acctgatctg gctggtgaag aagggcaact cctaccccaa gctgtccaag      540

tcctacatca acgacaaggg caaggaggtg ctggtgctgt ggggcatcca ccacccctcc      600

acctccgccg accagcagtc cctgtaccag aacgccgaca cctacgtgtt cgtgggctcc      660

tcccgctact ccaagaagtt caagcccgag atcgccatcc gccccaaggt gcgcgaccag      720

gagggccgca tgaactacta ctggaccctg gtggagcccg gcgacaagat caccttcgag      780

gccaccggca acctggtggt gccccgctac gccttcgcca tggagcgcaa cgccggctcc      840

ggcatcatca tctccgacac ccccgtgcac gactgcaaca ccacctgcca gacccccaag      900

ggcgccatca acacctccct gcccttccag aacatccacc ccatcaccat cggcaagtgc      960

cccaagtacg tgaagtccac caagctgcgc ctggccaccg gcctgcgcaa catcccctcc     1020

atccagtccc gcggcctgtt cggcgccatc gccggcttca tcgagggcgg ctggaccggc     1080

atggtggacg gctggtacgg ctaccaccac cagaacgagc agggctccgg ctacgccgcc     1140

gacctgaagt ccacccagaa cgccatcgac gagatcacca acaaggtgaa ctccgtgatc     1200

gagaagatga acacccagtt caccgccgtg ggcaaggagt tcaaccacct ggagaagcgc     1260

atcgagaacc tgaacaagaa ggtggacgac ggcttcctgg acatctggac ctacaacgcc     1320

gagctgctgg tgctgctgga gaacgagcgc accctggact accacgactc caacgtgaag     1380

aacctgtacg agaaggtgcg ctcccagctg aagaacaacg ccaaggagat cggcaacggc     1440

tgcttcgagt tctaccacaa gtgcgacaac acctgcatgg agtccgtgaa gaacggcacc     1500

tacgactacc ccaagtactc cgaggaggcc aagctgaacc gcgaggagat cgacggcgtg     1560

aagctggagt ccacccgcat ctaccagatc ctggccatct actccaccgt ggcctcctcc     1620

ctggtgctgg tggtgtccct gggcgccatc tccttctgga tgtgctccaa cggctccctg     1680

cagtgccgca tctgcatc                                                   1698


<210>  13
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - HA antigen Amino Acid sequence

<400>  13

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Asp Thr Leu Cys Ile Gly Tyr 
            20                  25                  30          


His Ala Asn Asn Ser Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn 
        35                  40                  45              


Val Thr Val Thr His Ser Val Asn Leu Leu Glu Asp Lys His Asn Gly 
    50                  55                  60                  


Lys Leu Cys Lys Leu Arg Gly Val Ala Pro Leu His Leu Gly Lys Cys 
65                  70                  75                  80  


Asn Ile Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser 
                85                  90                  95      


Thr Ala Ser Ser Trp Ser Tyr Ile Val Glu Thr Ser Asn Ser Asp Asn 
            100                 105                 110         


Gly Thr Cys Tyr Pro Gly Asp Phe Ile Asn Tyr Glu Glu Leu Arg Glu 
        115                 120                 125             


Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys 
    130                 135                 140                 


Thr Ser Ser Trp Pro Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala 
145                 150                 155                 160 


Cys Pro His Ala Gly Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu 
                165                 170                 175     


Val Lys Lys Gly Asn Ser Tyr Pro Lys Leu Asn Gln Ser Tyr Ile Asn 
            180                 185                 190         


Asp Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His His Pro Ser 
        195                 200                 205             


Thr Thr Ala Asp Gln Gln Ser Leu Tyr Gln Asn Ala Asp Ala Tyr Val 
    210                 215                 220                 


Phe Val Gly Thr Ser Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala 
225                 230                 235                 240 


Thr Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp 
                245                 250                 255     


Thr Leu Val Glu Pro Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn 
            260                 265                 270         


Leu Val Val Pro Arg Tyr Ala Phe Thr Met Glu Arg Asn Ala Gly Ser 
        275                 280                 285             


Gly Ile Ile Ile Ser Asp Thr Pro Val His Asp Cys Asn Thr Thr Cys 
    290                 295                 300                 


Gln Thr Pro Glu Gly Ala Ile Asn Thr Ser Leu Pro Phe Gln Asn Ile 
305                 310                 315                 320 


His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys Ser Thr Lys 
                325                 330                 335     


Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile Gln Ser Arg 
            340                 345                 350         


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly 
        355                 360                 365             


Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser 
    370                 375                 380                 


Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Lys Ile 
385                 390                 395                 400 


Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr 
                405                 410                 415     


Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn Leu 
            420                 425                 430         


Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala 
        435                 440                 445             


Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His Asp 
    450                 455                 460                 


Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Asn Gln Leu Lys Asn 
465                 470                 475                 480 


Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
                485                 490                 495     


Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro 
            500                 505                 510         


Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Lys Ile Asp Gly Val 
        515                 520                 525             


Lys Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr 
    530                 535                 540                 


Val Ala Ser Ser Leu Val Leu Val Val Ser Leu Gly Ala Ile Ser Phe 
545                 550                 555                 560 


Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 


<210>  14
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  14
atggccatct ccggcgtgcc cgtgctgggc ttcttcatca tcgccgtgct gatgtccgcc       60

caggagtcct gggccgacac cctgtgcatc ggctaccacg ccaacaactc caccgacacc      120

gtggacaccg tgctggagaa gaacgtgacc gtgacccact ccgtgaacct gctggaggac      180

aagcacaacg gcaagctgtg caagctgcgc ggcgtggccc ccctgcacct gggcaagtgc      240

aacatcgccg gctggatcct gggcaacccc gagtgcgagt ccctgtccac cgcctcctcc      300

tggtcctaca tcgtggagac ctccaactcc gacaacggca cctgctaccc cggcgacttc      360

atcaactacg aggagctgcg cgagcagctg tcctccgtgt cctccttcga gcggttcgag      420

atcttcccca agacctcctc ctggcccaac cacgactcca acaagggcgt gaccgccgcc      480

tgcccccacg ccggcgccaa gtccttctac aagaacctga tctggctggt gaagaagggc      540

aactcctacc ccaagctgaa ccagtcctac atcaacgaca agggcaagga ggtgctggtg      600

ctgtggggca tccaccaccc ctccaccacc gccgaccagc agtccctgta ccagaacgcc      660

gacgcctacg tgttcgtggg cacctcccgc tactccaaga agttcaagcc cgagatcgcc      720

acccgcccca aggtgcgcga ccaggagggc cgcatgaact actactggac cctggtggag      780

cccggcgaca agatcacctt cgaggccacc ggcaacctgg tggtgccccg ctacgccttc      840

accatggagc gcaacgccgg ctccggcatc atcatctccg acacccccgt gcacgactgc      900

aacaccacct gccagacccc cgagggcgcc atcaacacct ccctgccctt ccagaacatc      960

caccccatca ccatcggcaa gtgccccaag tacgtgaagt ccaccaagct gcgcctggcc     1020

accggcctgc gcaacgtgcc ctccatccag tcccgcggcc tgttcggcgc catcgccggc     1080

ttcatcgagg gcggctggac cggcatggtg gacggctggt acggctacca ccaccagaac     1140

gagcagggct ccggctacgc cgccgacctg aagtccaccc agaacgccat cgacaagatc     1200

accaacaagg tgaactccgt gatcgagaag atgaacaccc agttcaccgc cgtgggcaag     1260

gagttcaacc acctggagaa gcgcatcgag aacctgaaca agaaggtgga cgacggcttc     1320

ctggacatct ggacctacaa cgccgagctg ctggtgctgc tggagaacga gcgcaccctg     1380

gactaccacg actccaacgt gaagaacctg tacgagaagg tgcgcaacca gctgaagaac     1440

aacgccaagg agatcggcaa cggctgcttc gagttctacc acaagtgcga caacacctgc     1500

atggagtccg tgaagaacgg cacctacgac taccccaagt actccgagga ggccaagctg     1560

aaccgcgaga agatcgacgg cgtgaagctg gagtccaccc gcatctacca gatcctggcc     1620

atctactcca ccgtggcctc ctccctggtg ctggtggtgt ccctgggcgc catctccttc     1680

tggatgtgct ccaacggctc cctgcagtgc cgcatctgca tc                        1722


<210>  15
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - HA antigen Amino Acid sequence


<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Lys Thr Ile Ile Ala Leu Ser Cys Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Asn Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Ile Arg Gly Ser Lys 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Ser Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asn Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Xaa Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Arg Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Met Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  16
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen


<220>
<221>  misc_feature
<222>  (784)..(786)
<223>  any nucleotide

<400>  16
atgaagacca tcatcgccct gtcctgcatc ctgtgcctgg tgttcgccca gaagatcccc       60

ggcaacgaca actccaccgc caccctgtgc ctgggccacc acgccgtgcc caacggcacc      120

atcgtgaaga ccatcaccaa cgaccgcatc gaggtgacca acgccaccga gctggtgcag      180

aactcctcca tcggcgagat ctgcgactcc ccccaccaga tcctggacgg cgagaactgc      240

accctgatcg acgccctgct gggcgacccc cagtgcgacg gcttccagaa caagaagtgg      300

gacctgttcg tggagcgcaa caaggcctac tccaactgct acccctacga cgtgcccgac      360

tacgcctccc tgcgctccct ggtggcctcc tccggcaccc tggagttcaa caacgagtcc      420

ttcaactggg ccggcgtgac ccagaacggc acctcctcct cctgcatccg cggctccaag      480

tcctccttct tctcccgcct gaactggctg acccacctga actccaagta ccccgccctg      540

aacgtgacca tgcccaacaa cgagcagttc gacaagctgt acatctgggg cgtgcaccac      600

cccggcaccg acaagaacca gatctccctg tacgcccagt cctccggccg catcaccgtg      660

tccaccaagc gctcccagca ggccgtgatc cccaacatcg gctcccgccc ccgcatccgc      720

gacatcccct cccgcatctc catctactgg accatcgtga agcccggcga catcctgctg      780

atcnnntcca ccggcaacct gatcgccccc cgcggctact tcaagatccg ctccggcaag      840

tcctccatca tgcgctccga cgcccccatc ggcaagtgca agtccgagtg catcaccccc      900

aacggctcca tccccaacga caagcccttc cagaacgtga accgcatcac ctacggcgcc      960

tgcccccgct acgtgaagca gtccaccctg aagctggcca ccggcatgcg caacgtgccc     1020

gagcgccaga cccgcggcat cttcggcgcc atcgccggct tcatcgagaa cggctgggag     1080

ggcatggtgg acggctggta cggcttccgc caccagaact ccgagggccg cggccaggcc     1140

gccgacctga agtccaccca ggccgccatc gaccagatca acggcaagct gaaccgcctg     1200

atcggcaaga ccaacgagaa gttccaccag atcgagaagg agttctccga ggtggagggc     1260

cgcatccagg acctggagaa gtacgtggag gacaccaaga tcgacctgtg gtcctacaac     1320

gccgagctgc tggtggccct ggagaaccag cacaccatcg acctgaccga ctccgagatg     1380

aacaagctgt tcgagaagac caagaagcag ctgcgcgaga acgccgagga catgggcaac     1440

ggctgcttca agatctacca caagtgcgac aacgcctgca tgggctccat ccgcaacggc     1500

acctacgacc acaacgtgta ccgcgacgag gccctgaaca accgcttcca gatcaagggc     1560

gtggagctga agtccggcta caaggactgg atcctgtgga tctccttcgc catctcctgc     1620

ttcctgctgt gcgtggccct gctgggcttc atcatgtggg cctgccagaa gggcaacatc     1680

cgctgcaaca tctgcatc                                                   1698


<210>  17
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - HA antigen Amino Acid 
       sequence


<220>
<221>  misc_feature
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Ser Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Lys Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Val Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Gly 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ile Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Asp Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr 
            180                 185                 190         


Val Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Xaa Glu Thr Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Lys Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  18
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - Optimized DNA sequence 
       encoding the nucleic acid sequence encoding HA antigen


<220>
<221>  misc_feature
<222>  (628)..(630)
<223>  any nucleotide

<400>  18
atgaaggcca tcatcgtgct gctgatggtg gtgacctcct ccgccgaccg catctgcacc       60

ggcatcacct cctccaactc cccccacgtg gtgaagaccg ccacccaggg cgaggtgaac      120

gtgaccggcg tgatccccct gaccaccacc cccaccaagt cccacttcgc caacctgaag      180

ggcaccgaga cccgcggcaa gctgtgcccc aagtgcctga actgcaccga cctggacgtg      240

gccctgggcc gccccaagtg caccggcaag atcccctccg cccgcgtgtc catcctgcac      300

gaggtgcgcc ccgtgacctc cggctgcttc cccatcatgc acgaccgcac caagatccgc      360

cagctgccca acctgctgcg cggctacgag cacgtgcgcc tgtccaccca caacgtgatc      420

aacgccgagg gcgcccccgg cggcccctac aagatcggca cctccggctc ctgccccaac      480

atcaccaacg gcaacggctt cttcgccacc atggcctggg ccgtgcccga caagaacaag      540

accgccacca accccctgac catcgaggtg ccctacgtgt gcaccgaggg cgaggaccag      600

atcaccgtgt ggggcttcca ctccgacnnn gagacccaga tggccaagct gtacggcgac      660

tccaagcccc agaagttcac ctcctccgcc aacggcgtga ccacccacta cgtgtcccag      720

atcggcggct tccccaacca gaccgaggac ggcggcctgc cccagtccgg ccgcatcgtg      780

gtggactaca tggtgcagaa gtccggcaag accggcacca tcacctacca gcgcggcatc      840

ctgctgcccc agaaggtgtg gtgcgcctcc ggccgctcca aggtgatcaa gggctccctg      900

cccctgatcg gcgaggccga ctgcctgcac gagaagtacg gcggcctgaa caagtccaag      960

ccctactaca ccggcgagca cgccaaggcc atcggcaact gccccatctg ggtgaagacc     1020

cccctgaagc tggccaacgg caccaagtac cgcccccccg ccaagctgct gaaggagcgc     1080

ggcttcttcg gcgccatcgc cggcttcctg gagggcggct gggagggcat gatcgccggc     1140

tggcacggct acacctccca cggcgcccac ggcgtggccg tggccgccga cctgaagtcc     1200

acccaggagg ccatcaacaa gatcaccaag aacctgaact ccctgtccga gctggaggtg     1260

aagaacctgc agcgcctgtc cggcgccatg gacgagctgc acaacgagat cctggagctg     1320

gacgagaagg tggacgacct gcgcgccgac accatctcct cccagatcga gctggccgtg     1380

ctgctgtcca acgagggcat catcaactcc gaggacgagc acctgctggc cctggagcgc     1440

aagctgaaga agatgctggg cccctccgcc gtggagatcg gcaacggctg cttcgagacc     1500

aagcacaagt gcaaccagac ctgcctggac aagatcgccg ccggcacctt cgacgccggc     1560

gagttctccc tgcccacctt cgactccctg aacatcaccg ccgcctccct gaacgacgac     1620

ggcctggaca accacaccat cctgctgtac tactccaccg ccgcctcctc cctggccgtg     1680

accctgatga tcgccatctt cgtggtgtac atggtgtccc gcgacaacgt gtcctgctcc     1740

atctgcctg                                                             1749


<210>  19
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       HA antigen Amino Acid sequence


<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Xaa Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Glu Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Lys His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  20
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       Optimized DNA sequence encoding the nucleic acid sequence 
       encoding HA antigen


<220>
<221>  misc_feature
<222>  (637)..(639)
<223>  any nucleotide

<400>  20
atgaaggcca tcatcgtgct gctgatggtg gtgacctcca acgccgaccg catctgcacc       60

ggcatcacct cctccaactc cccccacgtg gtgaagaccg ccacccaggg cgaggtgaac      120

gtgaccggcg tgatccccct gaccaccacc cccaccaagt cctacttcgc caacctgaag      180

ggcacccgca cccgcggcaa gctgtgcccc gactgcctga actgcaccga cctggacgtg      240

gccctgggcc gccccatgtg cgtgggcacc accccctccg ccaaggcctc catcctgcac      300

gaggtgcgcc ccgtgacctc cggctgcttc cccatcatgc acgaccgcac caagatccgc      360

cagctgccca acctgctgcg cggctacgag aagatccgcc tgtccaccca gaacgtgatc      420

gacgccgaga aggcccccgg cggcccctac cgcctgggca cctccggctc ctgccccaac      480

gccacctcca agatcggctt cttcgccacc atggcctggg ccgtgcccaa ggacaactac      540

aagaacgcca ccaaccccct gaccgtggag gtgccctaca tctgcaccga gggcgaggac      600

cagatcaccg tgtggggctt ccactccgac aacaagnnnc agatgaagtc cctgtacggc      660

gactccaacc cccagaagtt cacctcctcc gccaacggcg tgaccaccca ctacgtgtcc      720

cagatcggcg acttccccga ccagaccgag gacggcggcc tgccccagtc cggccgcatc      780

gtggtggact acatgatgca gaagcccggc aagaccggca ccatcgtgta ccagcgcggc      840

gtgctgctgc cccagaaggt gtggtgcgcc tccggccgct ccaaggtgat caagggctcc      900

ctgcccctga tcggcgaggc cgactgcctg cacgaggagt acggcggcct gaacaagtcc      960

aagccctact acaccggcaa gcacgccaag gccatcggca actgccccat ctgggtgaag     1020

acccccctga agctggccaa cggcaccaag taccgccccc ccgccaagct gctgaaggag     1080

cgcggcttct tcggcgccat cgccggcttc ctggagggcg gctgggaggg catgatcgcc     1140

ggctggcacg gctacacctc ccacggcgcc cacggcgtgg ccgtggccgc cgacctgaag     1200

tccacccagg aggccatcaa caagatcacc aagaacctga actccctgtc cgagctggag     1260

gtgaagaacc tgcagcgcct gtccggcgcc atggacgagc tgcacaacga gatcctggag     1320

ctggacgaga aggtggacga cctgcgcgcc gacaccatct cctcccagat cgagctggcc     1380

gtgctgctgt ccaacgaggg catcatcaac tccgaggacg agcacctgct ggccctggag     1440

cgcaagctga agaagatgct gggcccctcc gccgtggaca tcggcaacgg ctgcttcgag     1500

accaagcaca agtgcaacca gacctgcctg gaccgcatcg ccgccggcac cttcaacgcc     1560

ggcgagttct ccctgcccac cttcgactcc ctgaacatca ccgccgcctc cctgaacgac     1620

gacggcctgg acaaccacac catcctgctg tactactcca ccgccgcctc ctccctggcc     1680

gtgaccctga tgctggccat cttcatcgtg tacatggtgt cccgcgacaa cgtgtcctgc     1740

tccatctgcc tg                                                         1752


<210>  21
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - HA antigen Amino Acid sequence

<400>  21

Met Glu Lys Ile Val Leu Leu Phe Ala Thr Ile Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp His Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Trp Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Val Asn Gly Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Asp Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Lys Gly Gly Ser Ala Ala Cys Ser Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asp Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Lys Asp Tyr Asn Asn Thr Asn Arg Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Lys Ala Glu Gln Ile Thr Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Ile Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Ile Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Ile Asp Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile His 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Arg Ser Glu Val Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Arg Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Arg Gly Leu Phe Gly Ala Lys Ala 
            340                 345                 350         


Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu 
    370                 375                 380                 


Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile 
385                 390                 395                 400 


Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn 
                405                 410                 415     


Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly 
            420                 425                 430         


Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu 
        435                 440                 445             


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
    450                 455                 460                 


Asp Lys Val Arg Leu Gln Leu Lys Asp Asn Ala Lys Glu Leu Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser 
                485                 490                 495     


Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg 
            500                 505                 510         


Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Val 
        515                 520                 525             


Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu 
    530                 535                 540                 


Ala Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser 
545                 550                 555                 560 


Leu Gln Cys Arg Ile Cys Ile 
                565         


<210>  22
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  22
atggagaaga tcgtgctgct gttcgccacc atctccctgg tgaagtccga ccacatctgc       60

atcggctacc acgccaacaa ctccaccgag caggtggaca ccatcatgga gaagaacgtg      120

accgtgaccc acgcccagga catcctggag aagacccaca acggcaagct gtgcgacctg      180

aacggcgtga agcccctgat cctgaaggac tgctccgtgg ccggctggct gctgggcaac      240

ccctggtgcg acgagttcat caacgtgccc gagtggtcct acatcgtgga gaaggccaac      300

cccgtgaacg gcctgtgcta ccccggcaac ttcaacgact acgaggagct gaagcacctg      360

ctgtcccgca tcaaccactt cgagaagatc cagatcatcc ccaaggactc ctggtccgac      420

cacgaggcct ccaagggcgg ctccgccgcc tgctcctacc agggcaagtc ctccttcttc      480

cgcaacgtgg tgtggctgat caagaagaac gacacctacc ccaccatcaa gaaggactac      540

aacaacacca accgcgagga cctgctggtg ctgtggggca tccaccaccc caacgacaag      600

gccgagcaga tcaccctgta ccagaacccc accacctaca tctccatcgg cacctccacc      660

ctgaaccagc gcctggtgcc caagatcgcc acccgctcca agatcaacgg ccagtccggc      720

cgcatcgact tcttctggac catcctgaag cccaacgacg ccatccactt cgagtccaac      780

ggcaacttca tcgcccccga gtacgcctac aagatcgtga agaagggcga ctccaccatc      840

atgcgctccg aggtggagta cggcaactgc aacacccgct gccagacccc cgtgggcgcc      900

atcaactcct ccatgccctt ccacaacatc caccccctga ccatcggcga gtgccccaag      960

tacgtgaagt ccaacaagct ggtgctggcc accggcctgc gcaactcccc ccagcgcgag     1020

cgccgccgca agcgcggcct gttcggcgcc aaggccggct tcatcgaggg cggctggcag     1080

ggcatggtgg acggctggta cggctaccac cactccaacg agcagggctc cggctacgcc     1140

gccgacaagg agtccaccca gaaggccatc gacggcgtga ccaacaaggt gaactccatc     1200

atcgacaaga tgaacaccca gttcgaggcc gtgggccgcg agttcaacaa cctggagcgc     1260

cgcatcgaga acctgaacaa gaagatggag gacggcttcc tggacgtgtg gacctacaac     1320

gccgagctgc tggtgctgat ggagaacgag cgcaccctgg acttccacga ctccaacgtg     1380

aagaacctgt acgacaaggt gcgcctgcag ctgaaggaca acgccaagga gctgggcaac     1440

ggctgcttcg agttctacca caagtgcaac aacgagtgca tggagtccgt gcgcaacggc     1500

acctacgact acccccagta ctccgaggag gcccgcctga agcgcgagga gatctccggc     1560

gtgaagctgg agtccatcgg cgtgtaccag atcctgtcca tctactccac cgtggcctcc     1620

tccctggtgc tggccatcat gatggccggc ctgtccctgt ggatgtgctc caacggctcc     1680

ctgcagtgcc gcatctgcat c                                               1701


<210>  23
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - HA antigen Amino Acid sequence

<400>  23

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asp Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys 
    50                  55                  60                  


Arg Thr Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly 
65                  70                  75                  80  


Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile 
                85                  90                  95      


Glu Arg Arg Glu Gly Ser Asp Phe Cys Tyr Pro Gly Lys Phe Val Asn 
            100                 105                 110         


Glu Glu Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys 
        115                 120                 125             


Glu Ala Met Gly Phe Thr Tyr Asn Gly Ile Arg Thr Asn Gly Val Thr 
    130                 135                 140                 


Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp 
145                 150                 155                 160 


Leu Leu Ser Asn Thr Asp Asn Ala Thr Phe Pro Gln Met Thr Lys Ser 
                165                 170                 175     


Tyr Lys Asn Thr Arg Lys Ser Pro Ala Ile Ile Val Trp Gly Ile His 
            180                 185                 190         


His Ser Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn 
        195                 200                 205             


Lys Leu Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro 
    210                 215                 220                 


Ser Pro Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp 
225                 230                 235                 240 


Phe His Trp Leu Ile Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe 
                245                 250                 255     


Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys 
            260                 265                 270         


Ser Met Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly 
        275                 280                 285             


Asp Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln 
    290                 295                 300                 


Asn Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln 
305                 310                 315                 320 


Arg Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro 
                325                 330                 335     


Lys Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly 
            340                 345                 350         


Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala 
        355                 360                 365             


Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile 
    370                 375                 380                 


Asp Gln Ile Ala Gly Lys Leu Asn Arg Leu Ile Ala Lys Thr Asn Gln 
385                 390                 395                 400 


Gln Phe Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile 
                405                 410                 415     


Gly Asn Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser 
            420                 425                 430         


Tyr Asn Ala Glu Leu Leu Ile Ala Met Glu Asn Gln His Thr Ile Asp 
        435                 440                 445             


Leu Ala Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln 
    450                 455                 460                 


Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe 
465                 470                 475                 480 


His Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr 
                485                 490                 495     


Asp His Arg Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile 
            500                 505                 510         


Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe 
        515                 520                 525             


Ser Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Val Val Met Gly Leu 
    530                 535                 540                 


Val Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
545                 550                 555                 560 


<210>  24
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  24
atgaacaccc agatcctggt gttcgccctg atcgccatca tccccaccaa cgccgacaag       60

atctgcctgg gccaccacgc cgtgtccaac ggcaccaagg tggacaccct gaccgagcgc      120

ggcgtggagg tggtgaacgc caccgagacc gtggagcgca ccaacatccc ccgcatctgc      180

tccaagggca agcgcaccgt ggacctgggc cagtgcggcc tgctgggcac catcaccggc      240

cccccccagt gcgaccagtt cctggagttc tccgccgacc tgatcatcga gcgccgcgag      300

ggctccgact tctgctaccc cggcaagttc gtgaacgagg aggccctgcg ccagatcctg      360

cgcgagtccg gcggcatcga caaggaggcc atgggcttca cctacaacgg catccgcacc      420

aacggcgtga cctccgcctg ccgccgctcc ggctcctcct tctacgccga gatgaagtgg      480

ctgctgtcca acaccgacaa cgccaccttc ccccagatga ccaagtccta caagaacacc      540

cgcaagtccc ccgccatcat cgtgtggggc atccaccact ccgtgtccac cgccgagcag      600

accaagctgt acggctccgg caacaagctg gtgaccgtgg gctcctccaa ctaccagcag      660

tccttcgtgc cctcccccgg cgcccgcccc caggtgaacg gcctgtccgg ccgcatcgac      720

ttccactggc tgatcctgaa ccccaacgac accgtgacct tctccttcaa cggcgccttc      780

atcgcccccg accgcgcctc cttcctgcgc ggcaagtcca tgggcatcca gtccggcgtg      840

caggtggacg ccaactgcga gggcgactgc taccactccg gcggcaccat catctccaac      900

ctgcccttcc agaacatcga ctcccgcgcc gtgggcaagt gcccccgcta cgtgaagcag      960

cgctccctgc tgctggccac cggcatgaag aacgtgcccg agatccccaa gggccgcggc     1020

ctgttcggcg ccatcgccgg cttcatcgag aacggctggg agggcctgat cgacggctgg     1080

tacggcttcc gccaccagaa cgcccagggc gagggcaccg ccgccgacta caagtccacc     1140

cagtccgcca tcgaccagat cgccggcaag ctgaaccgcc tgatcgccaa gaccaaccag     1200

cagttcgagc tgatcgacaa cgagttcaac gaggtggaga agcagatcgg caacgtgatc     1260

aactggaccc gcgactccat caccgaggtg tggtcctaca acgccgagct gctgatcgcc     1320

atggagaacc agcacaccat cgacctggcc gactccgaga tggacaagct gtacgagcgc     1380

gtgaagcgcc agctgcgcga gaacgccgag gaggacggca ccggctgctt cgagatcttc     1440

cacaagtgcg acgacgactg catggcctcc atccgcaaca acacctacga ccaccgcaag     1500

taccgcgagg aggccatgca gaaccgcatc cagatcgacc ccgtgaagct gtcctccggc     1560

tacaaggacg tgatcctgtg gttctccttc ggcgcctcct gcttcatcct gctggccgtg     1620

gtgatgggcc tggtgttcat ctgcgtgaag aacggcaaca tgcgctgcac catctgcatc     1680


<210>  25
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - HA antigen Amino Acid sequence

<400>  25

Met Tyr Lys Ile Val Val Ile Ile Ala Leu Leu Gly Ala Val Lys Gly 
1               5                   10                  15      


Leu Asp Lys Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr Ile 
            20                  25                  30          


Val Lys Thr Leu Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 
        35                  40                  45              


Thr Val Glu Ser Thr Gly Ile Asn Arg Leu Cys Met Lys Gly Arg Lys 
    50                  55                  60                  


His Lys Asp Leu Gly Asn Cys His Pro Ile Gly Met Leu Ile Gly Thr 
65                  70                  75                  80  


Pro Ala Cys Asp Leu His Leu Thr Gly Met Trp Asp Thr Leu Ile Glu 
                85                  90                  95      


Arg Glu Asn Ala Ile Ala Tyr Cys Tyr Pro Gly Ala Thr Val Asn Val 
            100                 105                 110         


Glu Ala Leu Arg Gln Lys Ile Met Glu Ser Gly Gly Ile Asn Lys Ile 
        115                 120                 125             


Ser Thr Gly Phe Thr Tyr Gly Ser Ser Ile Asn Ser Ala Gly Thr Thr 
    130                 135                 140                 


Arg Ala Cys Met Arg Asn Gly Gly Asn Ser Phe Tyr Ala Glu Leu Lys 
145                 150                 155                 160 


Trp Leu Val Ser Lys Ser Lys Gly Gln Asn Phe Pro Gln Thr Thr Asn 
                165                 170                 175     


Thr Tyr Arg Asn Thr Asp Thr Ala Glu His Leu Ile Met Trp Gly Ile 
            180                 185                 190         


His His Pro Ser Ser Thr Gln Glu Lys Asn Asp Leu Tyr Gly Thr Gln 
        195                 200                 205             


Ser Leu Ser Ile Ser Val Gly Ser Ser Thr Tyr Arg Asn Asn Phe Val 
    210                 215                 220                 


Pro Val Val Gly Ala Gly Pro Gln Val Asn Gly Gln Ser Gly Arg Ile 
225                 230                 235                 240 


Asp Phe His Trp Thr Leu Val Gln Pro Gly Asp Asn Ile Thr Phe Ser 
                245                 250                 255     


His Asn Gly Gly Leu Ile Ala Pro Ser Arg Val Ser Lys Leu Ile Gly 
            260                 265                 270         


Arg Gly Leu Gly Ile Gln Ser Asp Ala Pro Ile Asp Asn Asn Cys Glu 
        275                 280                 285             


Ser Lys Cys Phe Trp Arg Gly Gly Ser Ile Asn Thr Arg Leu Pro Phe 
    290                 295                 300                 


Gln Asn Leu Ser Pro Arg Thr Val Gly Gln Cys Pro Lys Tyr Val Asn 
305                 310                 315                 320 


Arg Arg Ser Leu Met Leu Ala Thr Gly Met Arg Asn Val Pro Glu Leu 
                325                 330                 335     


Ile Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Leu Glu Asn 
            340                 345                 350         


Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn 
        355                 360                 365             


Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr Lys Ser Thr Gln Ala Ala 
    370                 375                 380                 


Ile Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Val Glu Lys Thr Asn 
385                 390                 395                 400 


Thr Glu Phe Glu Ser Ile Glu Ser Glu Phe Ser Glu Ile Glu His Gln 
                405                 410                 415     


Ile Gly Asn Val Ile Asn Trp Thr Lys Asp Ser Ile Thr Asp Ile Trp 
            420                 425                 430         


Thr Tyr Gln Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile 
        435                 440                 445             


Asp Met Ala Asp Ser Glu Met Leu Asn Leu Tyr Glu Arg Val Arg Lys 
    450                 455                 460                 


Gln Leu Arg Gln Asn Ala Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile 
465                 470                 475                 480 


Tyr His Ala Cys Asp Asp Ser Cys Met Glu Ser Ile Arg Asn Asn Thr 
                485                 490                 495     


Tyr Asp His Ser Gln Tyr Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn 
            500                 505                 510         


Ile Asn Pro Val Thr Leu Ser Ser Gly Tyr Lys Asp Ile Ile Leu Trp 
        515                 520                 525             


Phe Ser Phe Gly Ala Ser Cys Phe Val Leu Leu Ala Val Val Met Gly 
    530                 535                 540                 


Leu Phe Phe Phe Cys Leu Lys Asn Gly Asn Met Arg Cys Thr Ile Cys 
545                 550                 555                 560 


Ile 
    


<210>  26
<211>  1683
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding HA antigen

<400>  26
atgtacaaga tcgtggtgat catcgccctg ctgggcgccg tgaagggcct ggacaagatc       60

tgcctgggcc accacgccgt ggccaacggc accatcgtga agaccctgac caacgagcag      120

gaggaggtga ccaacgccac cgagaccgtg gagtccaccg gcatcaaccg cctgtgcatg      180

aagggccgca agcacaagga cctgggcaac tgccacccca tcggcatgct gatcggcacc      240

cccgcctgcg acctgcacct gaccggcatg tgggacaccc tgatcgagcg cgagaacgcc      300

atcgcctact gctaccccgg cgccaccgtg aacgtggagg ccctgcgcca gaagatcatg      360

gagtccggcg gcatcaacaa gatctccacc ggcttcacct acggctcctc catcaactcc      420

gccggcacca cccgcgcctg catgcgcaac ggcggcaact ccttctacgc cgagctgaag      480

tggctggtgt ccaagtccaa gggccagaac ttcccccaga ccaccaacac ctaccgcaac      540

accgacaccg ccgagcacct gatcatgtgg ggcatccacc acccctcctc cacccaggag      600

aagaacgacc tgtacggcac ccagtccctg tccatctccg tgggctcctc cacctaccgc      660

aacaacttcg tgcccgtggt gggcgccggc ccccaggtga acggccagtc cggccgcatc      720

gacttccact ggaccctggt gcagcccggc gacaacatca ccttctccca caacggcggc      780

ctgatcgccc cctcccgcgt gtccaagctg atcggccgcg gcctgggcat ccagtccgac      840

gcccccatcg acaacaactg cgagtccaag tgcttctggc gcggcggctc catcaacacc      900

cgcctgccct tccagaacct gtccccccgc accgtgggcc agtgccccaa gtacgtgaac      960

cgccgctccc tgatgctggc caccggcatg cgcaacgtgc ccgagctgat ccagggccgc     1020

ggcctgttcg gcgccatcgc cggcttcctg gagaacggct gggagggcat ggtggacggc     1080

tggtacggct tccgccacca gaacgcccag ggcaccggcc aggccgccga ctacaagtcc     1140

acccaggccg ccatcgacca gatcaccggc aagctgaacc gcctggtgga gaagaccaac     1200

accgagttcg agtccatcga gtccgagttc tccgagatcg agcaccagat cggcaacgtg     1260

atcaactgga ccaaggactc catcaccgac atctggacct accaggccga gctgctggtg     1320

gccatggaga accagcacac catcgacatg gccgactccg agatgctgaa cctgtacgag     1380

cgcgtgcgca agcagctgcg ccagaacgcc gaggaggacg gcaagggctg cttcgagatc     1440

taccacgcct gcgacgactc ctgcatggag tccatccgca acaacaccta cgaccactcc     1500

cagtaccgcg aggaggccct gctgaaccgc ctgaacatca accccgtgac cctgtcctcc     1560

ggctacaagg acatcatcct gtggttctcc ttcggcgcct cctgcttcgt gctgctggcc     1620

gtggtgatgg gcctgttctt cttctgcctg aagaacggca acatgcgctg caccatctgc     1680

atc                                                                   1683


<210>  27
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mini HA domain - HA antigen Amino Acid sequence

<400>  27

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Lys Pro Ser Lys Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Thr Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Tyr Thr Ala 
    130                 135                 140                 


Ile Gly Cys Glu Tyr Asn Lys Ser Glu Arg Cys Met Lys Gln Ile Glu 
145                 150                 155                 160 


Asp Lys Ile Glu Glu Ile Glu Ser Lys Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Val Tyr Gln Ile Glu Gly Arg 
            260                 265             


<210>  28
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mini HA domain - Optimized DNA sequence encoding the nucleic acid
       sequence encoding HA antigen

<400>  28
atgaaggtga agctgctggt gctgctgtgc accttcaccg ccacctacgc cgacaccatc       60

tgcatcggct accacgccaa caactccacc gacaccgtgg acaccgtgct ggagaagaac      120

gtgaccgtga cccactccgt gaacctgctg gagaacggcg gcggcggcaa gtacgtgtgc      180

tccgccaagc tgcgcatggt gaccggcctg cgcaacaagc cctccaagca gtcccagggc      240

ctgttcggcg ccatcgccgg cttcaccgag ggcggctgga ccggcatggt ggacggctgg      300

tacggctacc accaccagaa cgagcagggc tccggctacg ccgccgacca gaagtccacc      360

cagaacgcca tcaacggcat caccaacaag gtgaactccg tgatcgagaa gatgaacacc      420

cagtacaccg ccatcggctg cgagtacaac aagtccgagc ggtgcatgaa gcagatcgag      480

gacaagatcg aggagatcga gtccaagatc tggtgctaca acgccgagct gctggtgctg      540

ctggagaacg agcgcaccct ggacttccac gactccaacg tgaagaacct gtacgagaag      600

gtgaagtccc agctgaagaa caacgccaag gagatcggca acggctgctt cgagttctac      660

cacaagtgca acgacgagtg catggagtcc gtgaagaacg gcacctacga ctaccccaag      720

tactccgagg agtccaagct gaaccgcgag aagatcgacg gcgtgaagct ggagtccatg      780

ggcgtgtacc agatcgaggg ccgc                                             804


<210>  29
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - NA antigen Amino Acid sequence

<400>  29

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Val Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Thr Gly Asn Gln Asn His Pro Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Ile Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Val Val Ala Gly Gln Asp Ala 
65                  70                  75                  80  


Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Leu 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Ile Lys Gly Phe Ser Phe Arg 
            340                 345                 350         


Tyr Asp Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Ser Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp 
    370                 375                 380                 


Ser Ser Phe Ser Val Arg Gln Asp Ile Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Gln Pro Lys 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Ser Ile Asp Lys 
465                 


<210>  30
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  30
atgaacccca accagaagat catcaccatc ggctccatct gcatggtggt gggcatcatc       60

tccctgatcc tgcagatcgg caacatcatc tccatctggg tgtcccactc catccagacc      120

ggcaaccaga accaccccga gacctgcaac cagtccatca tcacctacga gaacaacacc      180

tgggtgaacc agacctacgt gaacatctcc aacaccaacg tggtggccgg ccaggacgcc      240

acctccgtga tcctgaccgg caactcctcc ctgtgcccca tctccggctg ggccatctac      300

tccaaggaca acggcatccg catcggctcc aagggcgacg tgttcgtgat ccgcgagccc      360

ttcatctcct gctcccacct ggagtgccgc accttcttcc tgacccaggg cgccctgctg      420

aacgacaagc actccaacgg caccgtgaag gaccgctccc cctaccgcac cctgatgtcc      480

tgccccgtgg gcgaggcccc ctccccctac aactcccgct tcgagtccgt ggcctggtcc      540

gcctccgcct gccacgacgg catgggctgg ctgaccatcg gcatctccgg ccccgacaac      600

ggcgccgtgg ccgtgctgaa gtacaacggc atcatcaccg acaccatcaa gtcctggcgc      660

aacaacatcc tgcgcaccca ggagtccgag tgcgcctgcg tgaacggctc ctgcttcacc      720

atcatgaccg acggcccctc caacggccag gcctcctaca agatcctgaa gatcgagaag      780

ggcaaggtga ccaagtccat cgagctgaac gcccccaact accactacga ggagtgctcc      840

tgctaccccg acaccggcaa ggtgatgtgc gtgtgccgcg acaactggca cggctccaac      900

cgcccctggg tgtccttcga ccagaacctg gactaccaga tcggctacat ctgctccggc      960

gtgttcggcg acaacccccg ccccaacgac ggcaccggct cctgcggccc cgtgtcctcc     1020

aacggcgcca acggcatcaa gggcttctcc ttccgctacg acaacggcgt gtggatcggc     1080

cgcaccaagt ccacctcctc ccgctccggc ttcgagatga tctgggaccc caacggctgg     1140

accgagaccg actcctcctt ctccgtgcgc caggacatcg tggccatcac cgactggtcc     1200

ggctactccg gctccttcgt gcagcacccc gagctgaccg gcctggactg catgcgcccc     1260

tgcttctggg tggagctgat ccgcggccag cccaaggaga acaccatctg gacctccggc     1320

tcctccatct ccttctgcgg cgtgaactcc gacaccgtgg gctggtcctg gcccgacggc     1380

gccgagctgc ccttctccat cgacaag                                         1407


<210>  31
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - NA antigen Amino Acid sequence

<400>  31

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Ile 
1               5                   10                  15      


Ile Ala Thr Val Cys Phe Leu Met Gln Ile Ala Ile Leu Val Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln His Glu Cys Asp Ser Pro Ala Ser Asn 
        35                  40                  45              


Gln Val Met Pro Cys Glu Pro Ile Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Asn Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Val Val Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gln Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Gly Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His 
    130                 135                 140                 


Ser Asn Asp Thr Ile His Asp Arg Ile Pro His Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Val 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Val Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asp 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Arg Ala Asp Thr Arg Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Asp Val Arg 
        275                 280                 285             


Cys Ile Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Ile Asp 
    290                 295                 300                 


Ile Asn Met Glu Asp Tyr Ser Ile Asp Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Asn Asp Asp Arg Ser Ser Asn Ser Asn 
                325                 330                 335     


Cys Arg Asn Pro Asn Asn Glu Arg Gly Asn Pro Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asn Gly Asp Asp Val Trp Met Gly Arg Thr Ile Ser Lys 
        355                 360                 365             


Asp Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser 
    370                 375                 380                 


Thr Pro Asn Ser Lys Ser Gln Ile Asn Arg Gln Val Ile Val Asp Ser 
385                 390                 395                 400 


Asn Asn Trp Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Gln Gln 
            420                 425                 430         


Glu Thr Arg Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asn Ile 
    450                 455                 460                 


Asn Phe Met Pro Ile 
465                 


<210>  32
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  32
atgaacccca accagaagat catcaccatc ggctccgtgt ccctgatcat cgccaccgtg       60

tgcttcctga tgcagatcgc catcctggtg accaccgtga ccctgcactt caagcagcac      120

gagtgcgact cccccgcctc caaccaggtg atgccctgcg agcccatcat catcgagcgc      180

aacatcaccg agatcgtgta cctgaacaac accaccatcg agaaggagat ctgccccaag      240

gtggtggagt accgcaactg gtccaagccc cagtgccaga tcaccggctt cgcccccttc      300

tccaaggaca actccatccg cctgtccgcc ggcggcgaca tctgggtgac ccgcgagccc      360

tacgtgtcct gcgaccccgg caagtgctac cagttcgccc tgggccaggg caccaccctg      420

gacaacaagc actccaacga caccatccac gaccgcatcc cccaccgcac cctgctgatg      480

aacgagctgg gcgtgccctt ccacctgggc acccgccagg tgtgcgtggc ctggtcctcc      540

tcctcctgcc acgacggcaa ggcctggctg cacgtgtgcg tgaccggcga cgacaagaac      600

gccaccgcct ccttcatcta cgacggccgc ctggtggact ccatcggctc ctggtcccag      660

aacatcctgc gcacccagga gtccgagtgc gtgtgcatca acggcacctg caccgtggtg      720

atgaccgacg gctccgcctc cggccgcgcc gacacccgca tcctgttcat cgaggagggc      780

aagatcgtgc acatctcccc cctgtccggc tccgcccagc acgtggagga gtgctcctgc      840

tacccccgct accccgacgt gcgctgcatc tgccgcgaca actggaaggg ctccaaccgc      900

cccgtgatcg acatcaacat ggaggactac tccatcgact cctcctacgt gtgctccggc      960

ctggtgggcg acaccccccg caacgacgac cgctcctcca actccaactg ccgcaacccc     1020

aacaacgagc gcggcaaccc cggcgtgaag ggctgggcct tcgacaacgg cgacgacgtg     1080

tggatgggcc gcaccatctc caaggacctg cgctccggct acgagacctt caaggtgatc     1140

ggcggctggt ccacccccaa ctccaagtcc cagatcaacc gccaggtgat cgtggactcc     1200

aacaactggt ccggctactc cggcatcttc tccgtggagg gcaagtcctg catcaaccgc     1260

tgcttctacg tggagctgat ccgcggccgc cagcaggaga cccgcgtgtg gtggacctcc     1320

aactccatcg tggtgttctg cggcacctcc ggcacctacg gcaccggctc ctggcccgac     1380

ggcgccaaca tcaacttcat gcccatc                                         1407


<210>  33
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - NA antigen Amino Acid sequence

<400>  33

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ala Thr Val Cys Phe Leu Met Gln Ile Ala Ile Leu Val Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Cys Asp Ser Pro Ala Ser Asn 
        35                  40                  45              


Gln Val Met Pro Cys Glu Pro Ile Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Asn Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Val Val Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gln Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp His Gly Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asp Asn Lys His 
    130                 135                 140                 


Ser Asn Asp Thr Ile His Asp Arg Ile Pro His Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Arg Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asp 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Ile Gly Ser Trp Ser Gln Asn Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Arg Ala Asp Thr Arg Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Ile Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Val Asp 
    290                 295                 300                 


Ile Asn Met Glu Asp Tyr Ser Ile Asp Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Asn Asp Asp Arg Ser Ser Asn Ser Asn 
                325                 330                 335     


Cys Arg Asn Pro Asn Asn Glu Arg Gly Asn Gln Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asn Gly Asp Asp Val Trp Met Gly Arg Thr Ile Ser Lys 
        355                 360                 365             


Asp Leu Arg Ser Gly Tyr Glu Thr Phe Lys Val Ile Gly Gly Trp Ser 
    370                 375                 380                 


Thr Pro Asn Ser Lys Ser Gln Ile Asn Arg Gln Val Ile Val Asp Ser 
385                 390                 395                 400 


Asp Asn Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Gln 
            420                 425                 430         


Glu Thr Arg Val Trp Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asn Ile 
    450                 455                 460                 


Asn Phe Met Pro Ile 
465                 


<210>  34
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  34
atgaacccca accagaagat catcaccatc ggctccgtgt ccctgaccat cgccaccgtg       60

tgcttcctga tgcagatcgc catcctggtg accaccgtga ccctgcactt caagcagtac      120

gagtgcgact cccccgcctc caaccaggtg atgccctgcg agcccatcat catcgagcgc      180

aacatcaccg agatcgtgta cctgaacaac accaccatcg agaaggagat ctgccccaag      240

gtggtggagt accgcaactg gtccaagccc cagtgccaga tcaccggctt cgcccccttc      300

tccaaggaca actccatccg cctgtccgcc ggcggcgaca tctgggtgac ccgcgagccc      360

tacgtgtcct gcgaccacgg caagtgctac cagttcgccc tgggccaggg caccaccctg      420

gacaacaagc actccaacga caccatccac gaccgcatcc cccaccgcac cctgctgatg      480

aacgagctgg gcgtgccctt ccacctgggc acccgccagg tgtgcatcgc ctggtcctcc      540

tcctcctgcc acgacggcaa ggcctggctg cacgtgtgca tcaccggcga cgacaagaac      600

gccaccgcct ccttcatcta cgacggccgc ctggtggact ccatcggctc ctggtcccag      660

aacatcctgc gcacccagga gtccgagtgc gtgtgcatca acggcacctg caccgtggtg      720

atgaccgacg gctccgcctc cggccgcgcc gacacccgca tcctgttcat cgaggagggc      780

aagatcgtgc acatctcccc cctgtccggc tccgcccagc acgtggagga gtgctcctgc      840

tacccccgct accccggcgt gcgctgcatc tgccgcgaca actggaaggg ctccaaccgc      900

cccgtggtgg acatcaacat ggaggactac tccatcgact cctcctacgt gtgctccggc      960

ctggtgggcg acaccccccg caacgacgac cgctcctcca actccaactg ccgcaacccc     1020

aacaacgagc gcggcaacca gggcgtgaag ggctgggcct tcgacaacgg cgacgacgtg     1080

tggatgggcc gcaccatctc caaggacctg cgctccggct acgagacctt caaggtgatc     1140

ggcggctggt ccacccccaa ctccaagtcc cagatcaacc gccaggtgat cgtggactcc     1200

gacaaccgct ccggctactc cggcatcttc tccgtggagg gcaagtcctg catcaaccgc     1260

tgcttctacg tggagctgat ccgcggccgc aagcaggaga cccgcgtgtg gtggacctcc     1320

aactccatcg tggtgttctg cggcacctcc ggcacctacg gcaccggctc ctggcccgac     1380

ggcgccaaca tcaacttcat gcccatc                                         1407


<210>  35
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - NA antigen Amino Acid sequence

<400>  35

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Ala 
1               5                   10                  15      


Ile Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Val Val Ala Gly Lys Asp Thr 
65                  70                  75                  80  


Thr Ser Met Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asp Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Gln Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Val Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asp Gly Pro Ala Ser Tyr Arg Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Ile Thr Lys Ser Ile Glu Leu Asp Ala Pro 
            260                 265                 270         


Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Thr Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Lys Asp Gly Lys Gly Ser Cys Asp 
                325                 330                 335     


Pro Val Asn Val Asp Gly Ala Asp Gly Val Lys Gly Phe Ser Tyr Arg 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Ser Ser Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asp Thr Asp 
    370                 375                 380                 


Ser Asn Phe Leu Val Lys Gln Asp Val Val Ala Met Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Arg 
            420                 425                 430         


Glu Lys Thr Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly 
        435                 440                 445             


Val Asn Ser Asp Thr Val Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu 
    450                 455                 460                 


Pro Phe Thr Ile Asp Lys 
465                 470 


<210>  36
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  36
atgaacccca accagaagat catcaccatc ggctccatct gcatggccat cggcatcatc       60

tccctgatcc tgcagatcgg caacatcatc tccatctggg tgtcccactc catccagacc      120

ggctcccaga accacaccgg catctgcaac cagcgcatca tcacctacga gaactccacc      180

tgggtgaacc agacctacgt gaacatctcc aacaccaacg tggtggccgg caaggacacc      240

acctccatga ccctggccgg caactcctcc ctgtgcccca tccgcggctg ggccatctac      300

tccaaggaca actccatccg catcggctcc aagggcgacg tgttcgtgat ccgcgagccc      360

ttcatctcct gctcccacct ggagtgccgc accttcttcc tgacccaggg cgccctgctg      420

aacgacaagc actccaacgg caccgtgaag gaccgctccc cctaccgcgc cctgatgtcc      480

tgccccatcg gcgaggcccc ctccccctac aactcccgct tcgagtccgt ggcctggtcc      540

gcctccgcct gccacgacgg catgggctgg ctgaccatcg gcatctccgg ccccgacgac      600

ggcgccgtgg ccgtgctgaa gtacaacggc atcatcaccg agaccatcaa gtcctggcgc      660

aagcagatcc tgcgcaccca ggagtccgag tgcgtgtgcg tgaacggctc ctgcttcacc      720

atcatgaccg acggcccctc cgacggcccc gcctcctacc gcatcttcaa gatcgagaag      780

ggcaagatca ccaagtccat cgagctggac gcccccaact cccactacga ggagtgctcc      840

tgctaccccg acaccggcac cgtgatgtgc gtgtgccgcg acaactggca cggctccaac      900

cgcccctggg tgtccttcaa ccagaacctg gactaccaga tcggctacat ctgctccggc      960

gtgttcggcg acaacccccg ccccaaggac ggcaagggct cctgcgaccc cgtgaacgtg     1020

gacggcgccg acggcgtgaa gggcttctcc taccgctacg gcaacggcgt gtggatcggc     1080

cgcaccaagt ccaactcctc ccgcaagggc ttcgagatga tctgggaccc caacggctgg     1140

accgacaccg actccaactt cctggtgaag caggacgtgg tggccatgac cgactggtcc     1200

ggctactccg gctccttcgt gcagcacccc gagctgaccg gcctggactg catgcgcccc     1260

tgcttctggg tggagctgat ccgcggccgc ccccgcgaga agaccaccat ctggacctcc     1320

ggctcctcca tctccttctg cggcgtgaac tccgacaccg tgaactggtc ctggcccgac     1380

ggcgccgagc tgcccttcac catcgacaag                                      1410


<210>  37
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - NA antigen Amino Acid sequence

<400>  37

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Ile Ala 
1               5                   10                  15      


Ile Gly Ile Ile Ser Leu Met Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ala Ser His Ser Ile Gln Thr Gly Ser Gln Asn Asn Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Arg Ile Ile Thr Tyr Glu Asn Ser Thr Trp Val Asn His 
    50                  55                  60                  


Thr Tyr Val Asn Ile Asn Asn Thr Asn Val Val Ala Gly Glu Asp Lys 
65                  70                  75                  80  


Thr Ser Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Ser Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Thr Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser 
145                 150                 155                 160 


Cys Pro Leu Gly Glu Ala Pro Ser Pro Tyr Asn Ser Lys Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Gly Thr Ile Lys Ser Trp Lys Lys Gln Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Val Cys Met Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Lys Ala Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Phe His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Ile Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Glu Gly Ser Cys Asn 
                325                 330                 335     


Pro Val Thr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Lys 
            340                 345                 350         


Tyr Asp Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Asn Arg Leu Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Asn Thr Asp 
    370                 375                 380                 


Ser Asp Phe Ser Val Lys Gln Asp Val Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Val Arg Gly Leu Pro Arg 
            420                 425                 430         


Glu Asn Thr Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly 
        435                 440                 445             


Val Asn Ser Asp Thr Ala Asn Trp Ser Trp Pro Asp Gly Ala Glu Leu 
    450                 455                 460                 


Pro Phe Thr Ile Asp Lys 
465                 470 


<210>  38
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  38
atgaacccca accagaagat catcaccatc ggctccatct ccatcgccat cggcatcatc       60

tccctgatgc tgcagatcgg caacatcatc tccatctggg cctcccactc catccagacc      120

ggctcccaga acaacaccgg catctgcaac cagcgcatca tcacctacga gaactccacc      180

tgggtgaacc acacctacgt gaacatcaac aacaccaacg tggtggccgg cgaggacaag      240

acctccgtga ccctggccgg caactcctcc ctgtgctcca tctccggctg ggccatctac      300

accaaggaca actccatccg catcggctcc aagggcgacg tgttcgtgat ccgcgagccc      360

ttcatctcct gctcccacct ggagtgccgc accttcttcc tgacccaggg cgccctgctg      420

aacgacaagc actccaacgg caccgtgaag gaccgctccc cctaccgcgc cctgatgtcc      480

tgccccctgg gcgaggcccc ctccccctac aactccaagt tcgagtccgt ggcctggtcc      540

gcctccgcct gccacgacgg catgggctgg ctgaccatcg gcatctccgg ccccgacaac      600

ggcgccgtgg ccgtgctgaa gtacaacggc atcatcaccg gcaccatcaa gtcctggaag      660

aagcagatcc tgcgcaccca ggagtccgag tgcgtgtgca tgaacggctc ctgcttcacc      720

atcatgaccg acggcccctc caacaaggcc gcctcctaca agatcttcaa gatcgagaag      780

ggcaaggtga ccaagtccat cgagctgaac gcccccaact tccactacga ggagtgctcc      840

tgctaccccg acaccggcat cgtgatgtgc gtgtgccgcg acaactggca cggctccaac      900

cgcccctggg tgtccttcaa ccagaacctg gactaccaga tcggctacat ctgctccggc      960

gtgttcggcg acaacccccg ccccgaggac ggcgagggct cctgcaaccc cgtgaccgtg     1020

gacggcgcca acggcgtgaa gggcttctcc tacaagtacg acaacggcgt gtggatcggc     1080

cgcaccaagt ccaaccgcct gcgcaagggc ttcgagatga tctgggaccc caacggctgg     1140

accaacaccg actccgactt ctccgtgaag caggacgtgg tggccatcac cgactggtcc     1200

ggctactccg gctccttcgt gcagcacccc gagctgaccg gcctggactg catccgcccc     1260

tgcttctggg tggagctggt gcgcggcctg ccccgcgaga acaccaccat ctggacctcc     1320

ggctcctcca tctccttctg cggcgtgaac tccgacaccg ccaactggtc ctggcccgac     1380

ggcgccgagc tgcccttcac catcgacaag                                      1410


<210>  39
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - NA antigen Amino Acid sequence

<400>  39

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Cys Met Thr 
1               5                   10                  15      


Ile Gly Met Ala Asn Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Leu Gly Asn Gln Asn Gln Ile Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val 
65                  70                  75                  80  


Val Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Val Met Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Arg Ile Glu Lys Gly Lys Ile Val Lys Ser Val Glu Met Asn Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile 
        275                 280                 285             


Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Ile Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg 
        355                 360                 365             


Asn Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp 
    370                 375                 380                 


Asn Asn Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  40
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  40
atgaacccca accagaagat catcaccatc ggctccgtgt gcatgaccat cggcatggcc       60

aacctgatcc tgcagatcgg caacatcatc tccatctgga tctcccactc catccagctg      120

ggcaaccaga accagatcga gacctgcaac cagtccgtga tcacctacga gaacaacacc      180

tgggtgaacc agacctacgt gaacatctcc aacaccaact tcgccgccgg ccagtccgtg      240

gtgtccgtga agctggccgg caactcctcc ctgtgccccg tgtccggctg ggccatctac      300

tccaaggaca actccgtgcg catcggctcc aagggcgacg tgttcgtgat ccgcgagccc      360

ttcatctcct gctcccccct ggagtgccgc accttcttcc tgacccaggg cgccctgctg      420

aacgacaagc actccaacgg caccatcaag gaccgctccc cctaccgcac cctgatgtcc      480

tgccccatcg gcgaggtgcc ctccccctac aactcccgct tcgagtccgt ggcctggtcc      540

gcctccgcct gccacgacgg catcaactgg ctgaccatcg gcatctccgg ccccgacaac      600

ggcgccgtgg ccgtgctgaa gtacaacggc atcatcaccg acaccatcaa gtcctggcgc      660

aacaacatcc tgcgcaccca ggagtccgag tgcgcctgcg tgaacggctc ctgcttcacc      720

gtgatgaccg acggcccctc caacggccag gcctcctaca agatcttccg catcgagaag      780

ggcaagatcg tgaagtccgt ggagatgaac gcccccaact accactacga ggagtgctcc      840

tgctaccccg actcctccga gatcacctgc gtgtgccgcg acaactggca cggctccaac      900

cgcccctggg tgtccttcaa ccagaacctg gagtaccaga tcggctacat ctgctccggc      960

atcttcggcg acaacccccg ccccaacgac aagaccggct cctgcggccc cgtgtcctcc     1020

aacggcgcca acggcgtgaa gggcttctcc ttcaagtacg gcaacggcgt gtggatcggc     1080

cgcaccaagt ccatctcctc ccgcaacggc ttcgagatga tctgggaccc caacggctgg     1140

accggcaccg acaacaactt ctccatcaag caggacatcg tgggcatcaa cgagtggtcc     1200

ggctactccg gctccttcgt gcagcacccc gagctgaccg gcctggactg catccgcccc     1260

tgcttctggg tggagctgat ccgcggccgc cccaaggaga acaccatctg gacctccggc     1320

tcctccatct ccttctgcgg cgtgaactcc gacaccgtgg gctggtcctg gcccgacggc     1380

gccgagctgc ccttcaccat cgacaag                                         1407


<210>  41
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - NA antigen Amino Acid sequence


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Thr 
1               5                   10                  15      


Ile Gly Met Ala Asn Leu Ile Leu Gln Ile Gly Xaa Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Ile Gly Asn Gln Ser Gln Ile Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val 
65                  70                  75                  80  


Val Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile 
        275                 280                 285             


Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp 
    370                 375                 380                 


Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  42
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen


<220>
<221>  misc_feature
<222>  (82)..(84)
<223>  any nucleotide

<400>  42
atgaacccca accagaagat catcaccatc ggctccatct gcatgaccat cggcatggcc       60

aacctgatcc tgcagatcgg cnnnatcatc tccatctggg tgtcccactc catccagatc      120

ggcaaccagt cccagatcga gacctgcaac cagtccgtga tcacctacga gaacaacacc      180

tgggtgaacc agacctacgt gaacatctcc aacaccaact tcgccgccgg ccagtccgtg      240

gtgtccgtga agctggccgg caactcctcc ctgtgccccg tgtccggctg ggccatctac      300

tccaaggaca actccgtgcg catcggctcc aagggcgacg tgttcgtgat ccgcgagccc      360

ttcatctcct gctcccccct ggagtgccgc accttcttcc tgacccaggg cgccctgctg      420

aacgacaagc actccaacgg caccatcaag gaccgctccc cctaccgcac cctgatgtcc      480

tgccccatcg gcgaggtgcc ctccccctac aactcccgct tcgagtccgt ggcctggtcc      540

gcctccgcct gccacgacgg catcaactgg ctgaccatcg gcatctccgg ccccgactcc      600

ggcgccgtgg ccgtgctgaa gtacaacggc atcatcaccg acaccatcaa gtcctggcgc      660

aacaacatcc tgcgcaccca ggagtccgag tgcgcctgcg tgaacggctc ctgcttcacc      720

atcatgaccg acggcccctc cgacggccag gcctcctaca agatcttccg catcgagaag      780

ggcaagatca tcaagtccgt ggagatgaag gcccccaact accactacga ggagtgctcc      840

tgctaccccg actcctccga gatcacctgc gtgtgccgcg acaactggca cggctccaac      900

cgcccctggg tgtccttcaa ccagaacctg gagtaccaga tgggctacat ctgctccggc      960

gtgttcggcg acaacccccg ccccaacgac aagaccggct cctgcggccc cgtgtcctcc     1020

aacggcgcca acggcgtgaa gggcttctcc ttcaagtacg gcaacggcgt gtggatcggc     1080

cgcaccaagt ccatctcctc ccgcaagggc ttcgagatga tctgggaccc caacggctgg     1140

accggcaccg acaacaagtt ctccatcaag caggacatcg tgggcatcaa cgagtggtcc     1200

ggctactccg gctccttcgt gcagcacccc gagctgaccg gcctggactg catccgcccc     1260

tgcttctggg tggagctgat ccgcggccgc cccgaggaga acaccatctg gacctccggc     1320

tcctccatct ccttctgcgg cgtgaactcc gacaccgtgg gctggtcctg gcccgacggc     1380

gccgagctgc ccttcaccat cgacaag                                         1407


<210>  43
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - NA antigen Amino Acid sequence

<400>  43

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Arg Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Ile Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Ala Arg Asp Arg Thr Pro His Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Asn Ala Thr Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Lys Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Thr Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asn Pro Asn Asn Glu Lys Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Val Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met His Ile 
465                 


<210>  44
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  44
atgaacccca accagaagat catcaccatc ggctccgtgt ccctgaccat ctccaccatc       60

tgcttcttca tgcagatcgc catcctgatc accaccgtga ccctgcactt caagcagtac      120

gagttcaact ccccccccaa caaccaggtg atgctgtgcg agcccaccat catcgagcgc      180

aacatcaccg agatcgtgta cctgaccaac accaccatcg agcgcgagat ctgccccaag      240

cccgccgagt accgcaactg gtccaagccc cagtgcggca tcaccggctt cgcccccttc      300

tccaaggaca actccatccg cctgtccgcc ggcggcgaca tctgggtgac ccgcgagccc      360

tacgtgtcct gcgaccccga caagtgctac cagttcgccc tgggccaggg caccaccatc      420

aacaacgtgc actccaacaa caccgcccgc gaccgcaccc cccaccgcac cctgctgatg      480

aacgagctgg gcgtgccctt ccacctgggc accaagcagg tgtgcatcgc ctggtcctcc      540

tcctcctgcc acgacggcaa ggcctggctg cacgtgtgca tcaccggcga cgacaagaac      600

gccaccgcct ccttcatcta caacggccgc ctggtggact ccgtggtgtc ctggtccaag      660

gacatcctgc gcacccagga gtccgagtgc gtgtgcatca acggcacctg caccgtggtg      720

atgaccgacg gcaacgccac cggcaaggcc gacaccaaga tcctgttcat cgaggagggc      780

aagatcgtgc acacctccaa gctgtccggc tccgcccagc acgtggagga gtgctcctgc      840

tacccccgct accccggcgt gcgctgcgtg tgccgcgaca actggaaggg ctccaaccgc      900

cccatcgtgg acatcaacat caaggaccac tccatcgtgt cctcctacgt gtgctccggc      960

ctggtgggcg acaccccccg caagaccgac tcctcctcct cctcccactg cctgaacccc     1020

aacaacgaga agggcggcca cggcgtgaag ggctgggcct tcgacgacgg caacgacgtg     1080

tggatgggcc gcaccatcaa cgagacctcc cgcctgggct acgagacctt caaggtggtg     1140

gagggctggt ccaaccccaa gtccaagctg cagatcaacc gccaggtgat cgtggaccgc     1200

ggcgaccgct ccggctactc cggcatcttc tccgtggagg gcaagtcctg catcaaccgc     1260

tgcttctacg tggagctgat ccgcggccgc aaggaggaga ccgaggtgct gtggacctcc     1320

aactccatcg tggtgttctg cggcacctcc ggcacctacg gcaccggctc ctggcccgac     1380

ggcgccgacc tgaacctgat gcacatc                                         1407


<210>  45
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - NA antigen Amino Acid 
       sequence

<400>  45

Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 
            20                  25                  30          


Tyr Ser Asp Ile Leu Leu Lys Phe Ser Pro Thr Glu Ile Thr Ala Pro 
        35                  40                  45              


Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn 
    50                  55                  60                  


Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Asn Glu Cys Lys 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Asn Asn Ala Leu Leu Lys Val Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Ser Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Arg Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Asp 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly Pro 
                325                 330                 335     


Cys Glu Ser Asp Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Lys Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Gln Thr Glu Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Gly 
    370                 375                 380                 


Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Phe Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Met Lys Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met 
    450                 455                 460                 


Ala Leu 
465     


<210>  46
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - Optimized DNA sequence 
       encoding the nucleic acid sequence encoding NA antigen

<400>  46
atgctgccct ccaccatcca gaccctgacc ctgttcctga cctccggcgg cgtgctgctg       60

tccctgtacg tgtccgcctc cctgtcctac ctgctgtact ccgacatcct gctgaagttc      120

tcccccaccg agatcaccgc ccccaccatg cccctggact gcgccaacgc ctccaacgtg      180

caggccgtga accgctccgc caccaagggc gtgaccctgc tgctgcccga gcccgagtgg      240

acctaccccc gcctgtcctg ccccggctcc accttccaga aggccctgct gatctccccc      300

caccgcttcg gcgagaccaa gggcaactcc gcccccctga tcatccgcga gcccttcgtg      360

gcctgcggcc ccaacgagtg caagcacttc gccctgaccc actacgccgc ccagcccggc      420

ggctactaca acggcacccg cggcgaccgc aacaagctgc gccacctgat ctccgtgaag      480

ctgggcaaga tccccaccgt ggagaactcc atcttccaca tggccgcctg gtccggctcc      540

gcctgccacg acggcaagga gtggacctac atcggcgtgg acggccccga caacaacgcc      600

ctgctgaagg tgaagtacgg cgaggcctac accgacacct accactccta cgccaacaac      660

atcctgcgca cccaggagtc cgcctgcaac tgcatcggcg gcaactgcta cctgatgatc      720

accgacggct ccgcctccgg cgtgtccgag tgccgcttcc tgaagatccg cgagggccgc      780

atcatcaagg agatcttccc caccggccgc gtgaagcaca ccgaggagtg cacctgcggc      840

ttcgcctcca acaagaccat cgagtgcgcc tgccgcgaca accgctacac cgccaagcgc      900

cccttcgtga agctgaacgt ggagaccgac accgccgaga tccgcctgat gtgcaccgac      960

acctacctgg acaccccccg ccccaacgac ggctccatca ccggcccctg cgagtccgac     1020

ggcgacaagg gctccggcgg catcaagggc ggcttcgtgc accagcgcat gaagtccaag     1080

atcggccgct ggtactcccg caccatgtcc cagaccgagc gcatgggcat gggcctgtac     1140

gtgaagtacg gcggcgaccc ctgggccgac tccgacgccc tggccttctc cggcgtgatg     1200

gtgtccatga aggagcccgg ctggtactcc ttcggcttcg agatcaagga caagaagtgc     1260

gacgtgccct gcatcggcat cgagatggtg cacgacggcg gcaaggagac ctggcactcc     1320

gccgccaccg ccatctactg cctgatgggc tccggccagc tgctgtggga caccgtgacc     1380

ggcgtggaca tggccctg                                                   1398


<210>  47
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       NA antigen Amino Acid sequence

<400>  47

Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 
            20                  25                  30          


Tyr Ser Asp Ile Leu Leu Lys Phe Ser Arg Thr Glu Val Thr Ala Pro 
        35                  40                  45              


Ile Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn 
    50                  55                  60                  


Arg Ser Ala Thr Lys Gly Val Thr Pro Leu Leu Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys Lys 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Glu Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Ser Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Lys Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Ser Gly Ile Ser Glu Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Lys 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly Pro 
                325                 330                 335     


Cys Glu Ser Asp Gly Asp Glu Gly Ser Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp 
    370                 375                 380                 


Gly Asp Pro Trp Thr Asp Ser Glu Ala Leu Ala Leu Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Thr Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn Met 
    450                 455                 460                 


Thr Leu 
465     


<210>  48
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       Optimized DNA sequence encoding the nucleic acid sequence 
       encoding NA antigen

<400>  48
atgctgccct ccaccatcca gaccctgacc ctgttcctga cctccggcgg cgtgctgctg       60

tccctgtacg tgtccgcctc cctgtcctac ctgctgtact ccgacatcct gctgaagttc      120

tcccgcaccg aggtgaccgc ccccatcatg cccctggact gcgccaacgc ctccaacgtg      180

caggccgtga accgctccgc caccaagggc gtgacccccc tgctgcccga gcccgagtgg      240

acctaccccc gcctgtcctg ccccggctcc accttccaga aggccctgct gatctccccc      300

caccgcttcg gcgagaccaa gggcaactcc gcccccctga tcatccgcga gcccttcatc      360

gcctgcggcc ccaaggagtg caagcacttc gccctgaccc actacgccgc ccagcccggc      420

ggctactaca acggcacccg cgaggaccgc aacaagctgc gccacctgat ctccgtgaag      480

ctgggcaaga tccccaccgt ggagaactcc atcttccaca tggccgcctg gtccggctcc      540

gcctgccacg acggccgcga gtggacctac atcggcgtgg acggccccga ctccaacgcc      600

ctgctgaaga tcaagtacgg cgaggcctac accgacacct accactccta cgccaagaac      660

atcctgcgca cccaggagtc cgcctgcaac tgcatcggcg gcgactgcta cctgatgatc      720

accgacggcc ccgcctccgg catctccgag tgccgcttcc tgaagatccg cgagggccgc      780

atcatcaagg agatcttccc caccggccgc gtgaagcaca ccgaggagtg cacctgcggc      840

ttcgcctcca acaagaccat cgagtgcgcc tgccgcgaca actcctacac cgccaagcgc      900

cccttcgtga agctgaacgt ggagaccgac accgccgaga tccgcctgat gtgcaccaag      960

acctacctgg acaccccccg ccccaacgac ggctccatca ccggcccctg cgagtccgac     1020

ggcgacgagg gctccggcgg catcaagggc ggcttcgtgc accagcgcat ggcctccaag     1080

atcggccgct ggtactcccg caccatgtcc aagaccaagc gcatgggcat gggcctgtac     1140

gtgaagtacg acggcgaccc ctggaccgac tccgaggccc tggccctgtc cggcgtgatg     1200

gtgtccatgg aggagcccgg ctggtactcc ttcggcttcg agatcaagga caagaagtgc     1260

gacgtgccct gcatcggcat cgagatggtg cacgacggcg gcaagaccac ctggcactcc     1320

gccgccaccg ccatctactg cctgatgggc tccggccagc tgctgtggga caccgtgacc     1380

ggcgtgaaca tgaccctg                                                   1398


<210>  49
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - NA antigen Amino Acid sequence

<400>  49

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Ile 
1               5                   10                  15      


Ile Gly Ile Val Ser Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile 
            20                  25                  30          


Leu Val Ser His Ser Ile Gln Thr Gly Asn Gln His Gln Ala Glu Pro 
        35                  40                  45              


Ile Arg Asn Thr Asn Phe Leu Thr Glu Asn Ala Val Ala Ser Ile Thr 
    50                  55                  60                  


Leu Thr Gly Ser Ser Ser Leu Cys Pro Ile Arg Gly Trp Ala Val His 
65                  70                  75                  80  


Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
                85                  90                  95      


Ile Arg Glu Pro Phe Ile Ser Cys Ser His Met Glu Cys Arg Thr Phe 
            100                 105                 110         


Phe Leu Thr His Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
        115                 120                 125             


Val Lys Asp Arg Ser Pro His Arg Thr Leu Met Ser Cys Pro Val Gly 
    130                 135                 140                 


Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
145                 150                 155                 160 


Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly Ile Ser 
                165                 170                 175     


Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
            180                 185                 190         


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
        195                 200                 205             


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met Thr Asp 
    210                 215                 220                 


Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe Lys Ile Glu Lys 
225                 230                 235                 240 


Gly Lys Val Val Lys Ser Val Glu Leu Asn Ala Pro Asn Tyr His Tyr 
                245                 250                 255     


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Gly Glu Ile Met Cys Val Cys 
            260                 265                 270         


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Thr Phe Asn Gln 
        275                 280                 285             


Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
    290                 295                 300                 


Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly Pro Met Ser Leu 
305                 310                 315                 320 


Asn Gly Ala Tyr Gly Ile Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
                325                 330                 335     


Val Trp Ile Gly Arg Thr Lys Ser Thr Asn Ser Arg Ser Gly Phe Glu 
            340                 345                 350         


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Ser Glu Phe Ser 
        355                 360                 365             


Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr Ser Gly 
    370                 375                 380                 


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
385                 390                 395                 400 


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Ser Thr Ile 
                405                 410                 415     


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
            420                 425                 430         


Val Ser Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
        435                 440                 445             


Lys 
    


<210>  50
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  50
atgaacccca accagaagat catcaccatc ggctccatct gcatgatcat cggcatcgtg       60

tccctgatgc tgcagatcgg caacatgatc tccatcctgg tgtcccactc catccagacc      120

ggcaaccagc accaggccga gcccatccgc aacaccaact tcctgaccga gaacgccgtg      180

gcctccatca ccctgaccgg ctcctcctcc ctgtgcccca tccgcggctg ggccgtgcac      240

tccaaggaca actccatccg catcggctcc aagggcgacg tgttcgtgat ccgcgagccc      300

ttcatctcct gctcccacat ggagtgccgc accttcttcc tgacccacgg cgccctgctg      360

aacgacaagc actccaacgg caccgtgaag gaccgctccc cccaccgcac cctgatgtcc      420

tgccccgtgg gcgaggcccc ctccccctac aactcccgct tcgagtccgt ggcctggtcc      480

gcctccgcct gccacgacgg cacctcctgg ctgaccatcg gcatctccgg ccccgacaac      540

ggcgccgtgg ccgtgctgaa gtacaacggc atcatcaccg acaccatcaa gtcctggcgc      600

aacaacatcc tgcgcaccca ggagtccgag tgcgcctgcg tgaacggctc ctgcttcacc      660

gtgatgaccg acggcccctc caacggccag gcctcctaca agatcttcaa gatcgagaag      720

ggcaaggtgg tgaagtccgt ggagctgaac gcccccaact accactacga ggagtgctcc      780

tgctaccccg actccggcga gatcatgtgc gtgtgccgcg acaactggca cggctccaac      840

cgcccctggg tgaccttcaa ccagaacctg gagtaccaga tcggctacat ctgctccggc      900

gtgttcggcg acaacccccg ccccaacgac ggcaccggct cctgcggccc catgtccctg      960

aacggcgcct acggcatcaa gggcttctcc ttcaagtacg gcaacggcgt gtggatcggc     1020

cgcaccaagt ccaccaactc ccgctccggc ttcgagatga tctgggaccc caacggctgg     1080

accggcaccg actccgagtt ctccgtgaag caggacatcg tggccatcac cgactggtcc     1140

ggctactccg gctccttcgt gcagcacccc gagctgaccg gcctggactg catccgcccc     1200

tgcttctggg tggagctgat ccgcggccgc cccaaggagt ccaccatctg gacctccggc     1260

tcctccatct ccttctgcgg cgtgaactcc gacaccgtgt cctggtcctg gcccgacggc     1320

gccgagctgc ccttcaccat cgacaag                                         1347


<210>  51
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - NA antigen Amino Acid sequence

<400>  51

Met Asn Pro Asn Gln Lys Ile Leu Cys Thr Ser Ala Thr Ala Ile Thr 
1               5                   10                  15      


Ile Gly Ala Ile Ala Val Leu Ile Gly Ile Ala Asn Leu Gly Leu Asn 
            20                  25                  30          


Ile Gly Leu His Leu Lys Pro Gly Cys Asn Cys Ser His Ser Gln Pro 
        35                  40                  45              


Glu Ile Thr Asn Thr Ser Gln Thr Ile Ile Asn Asn Tyr Tyr Ser Glu 
    50                  55                  60                  


Thr Asn Ile Thr Asn Ile Gln Met Glu Glu Arg Thr Ser Lys Asn Phe 
65                  70                  75                  80  


Asn Asn Leu Thr Lys Gly Leu Cys Thr Ile Asn Ser Trp His Ile Tyr 
                85                  90                  95      


Gly Lys Asp Asn Ala Val Arg Ile Gly Glu Ser Ser Asp Val Leu Val 
            100                 105                 110         


Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Glu Cys Arg Phe Tyr 
        115                 120                 125             


Ala Leu Ser Gln Gly Thr Thr Ile Arg Gly Lys His Ser Asn Gly Thr 
    130                 135                 140                 


Ile His Asp Arg Ser Gln Tyr Arg Ala Leu Ile Ser Trp Pro Leu Ser 
145                 150                 155                 160 


Ser Pro Pro Thr Val Tyr Asn Ser Arg Val Glu Cys Ile Gly Trp Ser 
                165                 170                 175     


Ser Thr Ser Cys His Asp Gly Lys Ser Arg Met Ser Ile Cys Ile Ser 
            180                 185                 190         


Gly Pro Asn Asn Asn Ala Ser Ala Val Val Trp Tyr Asn Arg Arg Pro 
        195                 200                 205             


Val Ala Glu Ile Asn Thr Trp Ala Arg Asn Ile Leu Arg Thr Gln Glu 
    210                 215                 220                 


Ser Glu Cys Val Cys His Asn Gly Ile Cys Pro Val Val Phe Thr Asp 
225                 230                 235                 240 


Gly Ser Ala Thr Gly Pro Ala Asp Thr Arg Ile Tyr Tyr Phe Lys Glu 
                245                 250                 255     


Gly Lys Ile Leu Lys Trp Glu Ser Leu Thr Gly Thr Ala Lys His Val 
            260                 265                 270         


Glu Glu Cys Ser Cys Tyr Gly Glu Arg Thr Gly Ile Thr Cys Thr Cys 
        275                 280                 285             


Arg Asp Asn Trp Gln Gly Ser Asn Arg Pro Val Ile Gln Ile Asp Pro 
    290                 295                 300                 


Val Ala Met Thr His Thr Ser Gln Tyr Ile Cys Ser Pro Val Leu Thr 
305                 310                 315                 320 


Asp Asn Pro Arg Pro Asn Asp Pro Asn Ile Gly Lys Cys Asn Asp Pro 
                325                 330                 335     


Tyr Pro Gly Asn Asn Asn Asn Gly Ile Lys Gly Phe Ser Tyr Leu Asp 
            340                 345                 350         


Gly Asp Asn Thr Trp Leu Gly Arg Thr Ile Ser Thr Ala Ser Arg Ser 
        355                 360                 365             


Gly Tyr Glu Val Leu Lys Val Pro Asn Ala Leu Thr Asp Asp Arg Ser 
    370                 375                 380                 


Lys Pro Ile Gln Gly Gln Thr Ile Val Leu Asn Ala Asp Trp Ser Gly 
385                 390                 395                 400 


Tyr Ser Gly Ser Phe Met Asp Tyr Trp Ala Asp Gly Asp Cys Tyr Arg 
                405                 410                 415     


Ala Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asp Lys 
            420                 425                 430         


Val Trp Trp Thr Ser Asn Ser Ile Val Ser Met Cys Ser Ser Thr Glu 
        435                 440                 445             


Phe Leu Gly Gln Trp Asn Trp Pro Asp Gly Ala Lys Ile Glu Tyr Phe 
    450                 455                 460                 


Leu 
465 


<210>  52
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  52
atgaacccca accagaagat cctgtgcacc tccgccaccg ccatcaccat cggcgccatc       60

gccgtgctga tcggcatcgc caacctgggc ctgaacatcg gcctgcacct gaagcccggc      120

tgcaactgct cccactccca gcccgagatc accaacacct cccagaccat catcaacaac      180

tactactccg agaccaacat caccaacatc cagatggagg agcgcacctc caagaacttc      240

aacaacctga ccaagggcct gtgcaccatc aactcctggc acatctacgg caaggacaac      300

gccgtgcgca tcggcgagtc ctccgacgtg ctggtgaccc gcgagcccta cgtgtcctgc      360

gaccccgacg agtgccgctt ctacgccctg tcccagggca ccaccatccg cggcaagcac      420

tccaacggca ccatccacga ccgctcccag taccgcgccc tgatctcctg gcccctgtcc      480

tcccccccca ccgtgtacaa ctcccgcgtg gagtgcatcg gctggtcctc cacctcctgc      540

cacgacggca agtcccgcat gtccatctgc atctccggcc ccaacaacaa cgcctccgcc      600

gtggtgtggt acaaccgccg ccccgtggcc gagatcaaca cctgggcccg caacatcctg      660

cgcacccagg agtccgagtg cgtgtgccac aacggcatct gccccgtggt gttcaccgac      720

ggctccgcca ccggccccgc cgacacccgc atctactact tcaaggaggg caagatcctg      780

aagtgggagt ccctgaccgg caccgccaag cacgtggagg agtgctcctg ctacggcgag      840

cgcaccggca tcacctgcac ctgccgcgac aactggcagg gctccaaccg ccccgtgatc      900

cagatcgacc ccgtggccat gacccacacc tcccagtaca tctgctcccc cgtgctgacc      960

gacaaccccc gccccaacga ccccaacatc ggcaagtgca acgaccccta ccccggcaac     1020

aacaacaacg gcatcaaggg cttctcctac ctggacggcg acaacacctg gctgggccgc     1080

accatctcca ccgcctcccg ctccggctac gaggtgctga aggtgcccaa cgccctgacc     1140

gacgaccgct ccaagcccat ccagggccag accatcgtgc tgaacgccga ctggtccggc     1200

tactccggct ccttcatgga ctactgggcc gacggcgact gctaccgcgc ctgcttctac     1260

gtggagctga tccgcggccg ccccaaggag gacaaggtgt ggtggacctc caactccatc     1320

gtgtccatgt gctcctccac cgagttcctg ggccagtgga actggcccga cggcgccaag     1380

atcgagtact tcctg                                                      1395


<210>  53
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - NA antigen Amino Acid sequence

<400>  53

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Gly 
1               5                   10                  15      


Leu Val Ile Leu Asn Ile Leu Leu His Ile Val Ser Ile Thr Val Thr 
            20                  25                  30          


Val Leu Val Leu Pro Gly Asn Gly Asn Asn Glu Ser Cys Asn Glu Thr 
        35                  40                  45              


Val Ile Arg Glu Tyr Asn Glu Thr Val Arg Val Glu Lys Val Thr Gln 
    50                  55                  60                  


Trp His Asn Thr Asn Val Ile Glu Tyr Ile Glu Arg Pro Glu Asn Asp 
65                  70                  75                  80  


His Phe Met Asn Asn Thr Glu Ala Leu Cys Asp Ala Lys Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Thr Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Val Glu 
145                 150                 155                 160 


Ile Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ala Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Ile Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Ala Lys Ala Val Ala Val Val His Tyr Gly Gly 
        195                 200                 205             


Ile Pro Thr Asp Val Ile Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Gln Gly Glu Cys Phe Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Gln Tyr Arg Ala Phe Lys Ala 
                245                 250                 255     


Lys Gln Gly Lys Ile Val Gly Gln Ala Glu Ile Ser Phe Asn Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Glu Gly Lys Val Glu Cys 
        275                 280                 285             


Val Cys Lys Asp Asn Trp Thr Gly Thr Asn Arg Pro Val Leu Val Ile 
    290                 295                 300                 


Ser Pro Asp Leu Ser Tyr Arg Val Gly Tyr Leu Cys Ala Gly Leu Pro 
305                 310                 315                 320 


Ser Asp Thr Pro Arg Gly Glu Asp Ser Gln Phe Thr Gly Ser Cys Thr 
                325                 330                 335     


Ser Pro Met Gly Asn Gln Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Asn Asp Val Trp Met Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Leu Lys Val Arg Asn Gly Trp Val Gln Asn Ser 
    370                 375                 380                 


Lys Glu Gln Ile Lys Arg Gln Val Val Val Asp Asn Leu Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Ala Glu Leu Thr Lys Arg Asn 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Asn Pro Glu 
            420                 425                 430         


Glu Lys Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp His Glu Ile Ala Asp Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Met 
465                 470 


<210>  54
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NA antigen

<400>  54
atgaacccca accagaagat catcaccatc ggctccgtgt ccctgggcct ggtgatcctg       60

aacatcctgc tgcacatcgt gtccatcacc gtgaccgtgc tggtgctgcc cggcaacggc      120

aacaacgagt cctgcaacga gaccgtgatc cgcgagtaca acgagaccgt gcgcgtggag      180

aaggtgaccc agtggcacaa caccaacgtg atcgagtaca tcgagcgccc cgagaacgac      240

cacttcatga acaacaccga ggccctgtgc gacgccaagg gcttcgcccc cttctccaag      300

gacaacggca tccgcatcgg ctcccgcggc cacgtgttcg tgatccgcga gcccttcgtg      360

tcctgctccc ccaccgagtg ccgcaccttc ttcctgaccc agggctccct gctgaacgac      420

aagcactcca acggcaccgt gaaggaccgc tccccctacc gcaccctgat gtccgtggag      480

atcggccagt cccccaacgt gtaccaggcc cgcttcgagg ccgtggcctg gtccgccacc      540

gcctgccacg acggcaagaa gtggatgacc atcggcgtga ccggccccga cgccaaggcc      600

gtggccgtgg tgcactacgg cggcatcccc accgacgtga tcaactcctg ggccggcgac      660

atcctgcgca cccaggagtc ctcctgcacc tgcatccagg gcgagtgctt ctgggtgatg      720

accgacggcc ccgccaaccg ccaggcccag taccgcgcct tcaaggccaa gcagggcaag      780

atcgtgggcc aggccgagat ctccttcaac ggcggccaca tcgaggagtg ctcctgctac      840

cccaacgagg gcaaggtgga gtgcgtgtgc aaggacaact ggaccggcac caaccgcccc      900

gtgctggtga tctcccccga cctgtcctac cgcgtgggct acctgtgcgc cggcctgccc      960

tccgacaccc cccgcggcga ggactcccag ttcaccggct cctgcacctc ccccatgggc     1020

aaccagggct acggcgtgaa gggcttcggc ttccgccagg gcaacgacgt gtggatgggc     1080

cgcaccatct cccgcacctc ccgctccggc ttcgagatcc tgaaggtgcg caacggctgg     1140

gtgcagaact ccaaggagca gatcaagcgc caggtggtgg tggacaacct gaactggtcc     1200

ggctactccg gctccttcac cctgcccgcc gagctgacca agcgcaactg cctggtgccc     1260

tgcttctggg tggagatgat ccgcggcaac cccgaggaga agaccatctg gacctcctcc     1320

tcctccatcg tgatgtgcgg cgtggaccac gagatcgccg actggtcctg gcacgacggc     1380

gccatcctgc ccttcgacat cgacaagatg                                      1410


<210>  55
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - NP antigen Amino Acid sequence

<400>  55

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Ile Asp Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val 
            340                 345                 350         


Val Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Thr Met Asp Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  56
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  56
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccgacgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc cgcatgatcg gcggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgagg gccgcctgat ccagaactcc      180

atcaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgcatc      300

gacggcaagt ggatgcgcga gctgatcctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga ggacgccacc gccggcctga cccacatgat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatggtg atggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgcc gcacccgcat cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggccccg ccgtggcctc cggctacgac ttcgagcgcg agggctactc cctggtgggc      900

atcgacccct tccgcctgct gcagaactcc caggtgtact ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcacc cgcgtggtgc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggagacca tggactcctc caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc cgtgcagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagcgcgcca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcaccgaga tcatccgcat gatggagtcc gcccgccccg aggacgtgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccacctccc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  57
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - NP antigen Amino Acid sequence

<400>  57

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Lys Arg Val Asp Gly Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Val Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys Asn Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Ala Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Lys Pro Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Gly Ala Lys Pro Glu Glu Met Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  58
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  58
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccgacgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc aagatgatcg acggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgagg gccgcctgat ccagaactcc      180

ctgaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta caagcgcgtg      300

gacggcaagt ggatgcgcga gctggtgctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga cgacgccacc gccggcctga cccacatgat gatctggcac      420

tccaacctga acgacaccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatggtg atggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgca agacccgctc cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggccccg ccgtggcctc cggctacgtg ttcgagaagg agggctactc cctggtgggc      900

atcgacccct tcaagctgct gcagaactcc caggtgtact ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgca actccgccgc cttcgaggac     1020

ctgcgcgtgc tgtccttcat ccgcggcacc aaggtgtccc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggacacca tggagtcctc caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc cgtgcagccc gccttctccg tgcagcgcaa cctgcccttc     1260

gacaagccca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcgccgaga tcatccgcat gatggagggc gccaagcccg aggagatgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccaccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  59
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - NP antigen Amino Acid sequence

<400>  59

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Lys Arg Val Asp Arg Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys Asn Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Ala Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Ala Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Lys Pro Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Gly Ala Lys Pro Glu Glu Met Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Arg Ala Ala Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  60
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  60
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccgacgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc aagatgatcg acggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgagg gccgcctgat ccagaactcc      180

ctgaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta caagcgcgtg      300

gaccgcaagt ggatgcgcga gctggtgctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga cgacgccacc gccggcctga cccacatgat gatctggcac      420

tccaacctga acgacaccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatggtg atggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgca agacccgctc cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggccccg ccgtggcctc cggctacgac ttcgagaagg agggctactc cctggtgggc      900

atcgacccct tcaagctgct gcagaactcc caggtgtact ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgca actccgccgc cttcgaggac     1020

ctgcgcgtgc tgtccttcat ccgcggcacc aaggtgtccc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggacgcca tggagtcctc caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc cgtgcagccc gccttctccg tgcagcgcaa cctgcccttc     1260

gacaagccca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcgccgaga tcatccgcat gatggagggc gccaagcccg aggagatgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagcgc gccgccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  61
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - NP antigen Amino Acid sequence

<400>  61

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Lys Arg Val Asp Gly Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Leu Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asn Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Thr Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys Asn Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ile Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Thr Met Gly Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Lys Thr Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Ala Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Lys Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Glu Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Arg Ala Ala Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  62
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  62
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccgacgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc aagatgatcg acggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgagg gccgcctgat ccagaactcc      180

ctgaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta caagcgcgtg      300

gacggcaagt ggatgcgcga gctggtgctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga cgacgccacc gccggcctga cccacatgat gatctggcac      420

tccaacctga acgacaccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatggtg ctggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgca agacccgcat cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggccccg ccgtggcctc cggctacaac ttcgagaagg agggctactc cctggtgggc      900

atcgacccct tcaagctgct gcagacctcc caggtgtact ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgca actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcacc aaggtgatcc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggacacca tgggctcctc caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc catccagccc accttctccg tgcagcgcaa cctgcccttc     1260

gacaagacca ccatcatggc cgccttcacc ggcaacgccg agggccgcac ctccgacatg     1320

cgcgccgaga tcatcaagat gatggagtcc gcccgccccg aggaggtgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagcgc gccgccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  63
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - NP antigen Amino Acid sequence

<400>  63

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Asn Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Lys Arg Val Asp Gly Lys Trp Val Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Ile Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Leu Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Val Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Thr Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys Asn Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val 
            340                 345                 350         


Leu Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Ala Ile Val Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Thr Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Lys Ala Thr Ile Met Ala Ala Phe Ser Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Lys Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Glu Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Arg Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  64
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  64
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccgacgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc cgcatgatcg gcggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgaac gactacgagg gccgcctgat ccagaactcc      180

ctgaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta caagcgcgtg      300

gacggcaagt gggtgcgcga gctggtgctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga cgacgccacc gccggcctga cccacatcat gatctggcac      420

tccaacctga acgacaccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatggtg ctggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgca agacccgcat cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagaaggc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgac cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggccccg ccgtggcctc cggctacgac ttcgagaagg agggctactc cctggtgggc      900

gtggacccct tcaagctgct gcagacctcc caggtgtact ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgca actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcacc cgcgtgctgc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggacgcca tcgtgtcctc caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc cacccagccc accttctccg tgcagcgcaa cctgcccttc     1260

gacaaggcca ccatcatggc cgccttctcc ggcaacaccg agggccgcac ctccgacatg     1320

cgcgccgaga tcatcaagat gatggagtcc gcccgccccg aggaggtgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagcgc gccaccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  65
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - NP antigen Amino Acid sequence

<400>  65

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 
1               5                   10                  15      


Gly Glu Arg Gln Asp Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Asp Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asp Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Val Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Ile Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Ile Ala Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Val Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 
        275                 280                 285             


His Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Val Ser Leu Met Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Lys Lys Val 
            340                 345                 350         


Ile Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Val Glu Thr Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Lys 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Val Met Ala Ala Phe Ser Gly Asn 
            420                 425                 430         


Asn Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Val Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Lys Pro Glu Asp Leu Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Ser 
        


<210>  66
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  66
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccggcgg cgagcgccag       60

gacgccaccg agatccgcgc ctccgtgggc cgcatgatcg gcggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgacg gccgcctgat ccagaactcc      180

atcaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgcgtg      300

gacggcaagt ggatgcgcga gctgatcctg tacgacaagg aggagatccg ccgcgtgtgg      360

cgccaggcca acaacggcga ggacgccacc gccggcctga cccacatcat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatcgcc atggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgcc gcacccgcgt ggcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggcctgg ccgtggcctc cggccacgac ttcgagcgcg agggctactc cctggtgggc      900

atcgacccct tcaagctgct gcagaactcc caggtggtgt ccctgatgcg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcaag aaggtgatcc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac gtggagacca tggactccaa caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagaag     1200

gcctccgccg gccagatctc cgtgcagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagcgcgcca ccgtgatggc cgccttctcc ggcaacaacg agggccgcac ctccgacatg     1320

cgcaccgagg tgatccgcat gatggagtcc gccaagcccg aggacctgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccaccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga ctcc           1494


<210>  67
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - NP antigen Amino Acid sequence

<400>  67

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 
1               5                   10                  15      


Gly Glu Arg Gln Asp Thr Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Asp Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Ile Asp Gly Lys Trp Thr Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Val Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Ile Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Ile Ala Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Val Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 
        275                 280                 285             


His Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Val Ser Leu Met Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Lys Lys Val 
            340                 345                 350         


Ile Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Val Glu Thr Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Lys 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Val Met Ala Ala Phe Ser Gly Asn 
            420                 425                 430         


Asn Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Val Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Lys Pro Glu Asp Leu Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  68
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  68
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccggcgg cgagcgccag       60

gacaccaccg agatccgcgc ctccgtgggc cgcatgatcg gcggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgacg gccgcctgat ccagaactcc      180

atcaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgcatc      300

gacggcaagt ggacccgcga gctgatcctg tacgacaagg aggagatccg ccgcgtgtgg      360

cgccaggcca acaacggcga ggacgccacc gccggcctga cccacatcat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatcgcc atggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgcc gcacccgcgt ggcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggcctgg ccgtggcctc cggccacgac ttcgagcgcg agggctactc cctggtgggc      900

atcgacccct tcaagctgct gcagaactcc caggtggtgt ccctgatgcg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcaag aaggtgatcc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac gtggagacca tggactccaa caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagaag     1200

gcctccgccg gccagatctc cgtgcagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagcgcgcca ccgtgatggc cgccttctcc ggcaacaacg agggccgcac ctccgacatg     1320

cgcaccgagg tgatccgcat gatggagtcc gccaagcccg aggacctgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccaccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  69
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - NP antigen Amino Acid sequence


<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<400>  69

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Asp Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp His Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Lys Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asp Xaa Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ser Gly Leu Thr His Ile Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Ile Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Val Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Val Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Ala Tyr Gly Pro Ala Val Ser Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Ile Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Leu Leu Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Asn Met Gly Ser Ser Thr Leu Glu Leu Arg Ser Gly 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Thr Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Lys Ser Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Gly Ala Lys Pro Glu Glu Val Ser Phe Arg Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Ala Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  70
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen


<220>
<221>  misc_feature
<222>  (304)..(306)
<223>  any nucleotide

<400>  70
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccgacgg cgaccgccag       60

aacgccaccg agatccgcgc ctccgtgggc aagatgatcg acggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gaccacgagg gccgcctgat ccagaactcc      180

ctgaccatcg agaagatggt gctgtccgcc ttcgacgagc gccgcaacaa gtacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgcgtg      300

gacnnnaagt ggatgcgcga gctggtgctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga ggacgccacc tccggcctga cccacatcat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcatcgg caccatggtg atggagctga tccgcatggt gaagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgca agacccgctc cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catggtggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgcc      840

tacggccccg ccgtgtcctc cggctacgac ttcgagaagg agggctactc cctggtgggc      900

atcgacccct tcaagctgct gcagaactcc cagatctact ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcctgc tgtccttcat ccgcggcacc aaggtgtccc cccgcggcaa gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggacaaca tgggctcctc caccctggag     1140

ctgcgctccg gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagacctc cgtgcagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagaagtcca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcgccgaga tcatccgcat gatggagggc gccaagcccg aggaggtgtc cttccgcggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccgccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  71
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - NP antigen Amino Acid 
       sequence.

<400>  71

Met Ser Asn Met Asp Ile Asp Gly Met Asn Thr Gly Thr Ile Asp Lys 
1               5                   10                  15      


Thr Pro Glu Glu Ile Thr Ser Gly Thr Ser Gly Thr Thr Arg Pro Ile 
            20                  25                  30          


Ile Arg Pro Ala Thr Leu Ala Pro Pro Ser Asn Lys Arg Thr Arg Asn 
        35                  40                  45              


Pro Ser Pro Glu Arg Ala Thr Thr Ser Ser Glu Asp Asp Val Gly Arg 
    50                  55                  60                  


Lys Ala Gln Lys Lys Gln Thr Pro Thr Glu Ile Lys Lys Ser Val Tyr 
65                  70                  75                  80  


Asn Met Val Val Lys Leu Gly Glu Phe Tyr Asn Gln Met Met Val Lys 
                85                  90                  95      


Ala Gly Leu Asn Asp Asp Met Glu Arg Asn Leu Ile Gln Asn Ala His 
            100                 105                 110         


Ala Val Glu Arg Ile Leu Leu Ala Ala Thr Asp Asp Lys Lys Thr Glu 
        115                 120                 125             


Phe Gln Lys Lys Lys Asn Ala Arg Asp Val Lys Glu Gly Lys Glu Glu 
    130                 135                 140                 


Ile Asp His Asn Lys Thr Gly Gly Thr Phe Tyr Lys Met Val Arg Asp 
145                 150                 155                 160 


Asp Lys Thr Ile Tyr Phe Ser Pro Ile Arg Ile Thr Phe Leu Lys Glu 
                165                 170                 175     


Glu Val Lys Thr Met Tyr Lys Thr Thr Met Gly Ser Asp Gly Phe Ser 
            180                 185                 190         


Gly Leu Asn His Ile Met Ile Gly His Ser Gln Met Asn Asp Val Cys 
        195                 200                 205             


Phe Gln Arg Ser Lys Ala Leu Lys Arg Val Gly Leu Asp Pro Ser Leu 
    210                 215                 220                 


Ile Ser Thr Phe Ala Gly Ser Thr Val Pro Arg Arg Ser Gly Ala Thr 
225                 230                 235                 240 


Gly Val Ala Ile Lys Gly Gly Gly Thr Leu Val Ala Glu Ala Ile Arg 
                245                 250                 255     


Phe Ile Gly Arg Ala Met Ala Asp Arg Gly Leu Leu Arg Asp Ile Lys 
            260                 265                 270         


Ala Lys Thr Ala Tyr Glu Lys Ile Leu Leu Asn Leu Lys Asn Lys Cys 
        275                 280                 285             


Ser Ala Pro Gln Gln Lys Ala Leu Val Asp Gln Val Ile Gly Ser Arg 
    290                 295                 300                 


Asn Pro Gly Ile Ala Asp Ile Glu Asp Leu Thr Leu Leu Ala Arg Ser 
305                 310                 315                 320 


Met Val Val Val Arg Pro Ser Val Ala Ser Lys Val Val Leu Pro Ile 
                325                 330                 335     


Ser Ile Tyr Ala Lys Ile Pro Gln Leu Gly Phe Asn Val Glu Glu Tyr 
            340                 345                 350         


Ser Met Val Gly Tyr Glu Ala Met Ala Leu Tyr Asn Met Ala Thr Pro 
        355                 360                 365             


Val Ser Ile Leu Arg Met Gly Asp Asp Ala Lys Asp Lys Ser Gln Leu 
    370                 375                 380                 


Phe Phe Met Ser Cys Phe Gly Ala Ala Tyr Glu Asp Leu Arg Val Leu 
385                 390                 395                 400 


Ser Ala Leu Thr Gly Thr Glu Phe Lys Pro Arg Ser Ala Leu Lys Cys 
                405                 410                 415     


Lys Gly Phe His Val Pro Ala Lys Glu Gln Val Glu Gly Met Gly Ala 
            420                 425                 430         


Ala Leu Met Ser Ile Lys Leu Gln Phe Trp Ala Pro Met Thr Arg Ser 
        435                 440                 445             


Gly Gly Asn Glu Val Gly Gly Asp Gly Gly Ser Gly Gln Ile Ser Cys 
    450                 455                 460                 


Ser Pro Val Phe Ala Val Glu Arg Pro Ile Ala Leu Ser Lys Gln Ala 
465                 470                 475                 480 


Val Arg Arg Met Leu Ser Met Asn Ile Glu Gly Arg Asp Ala Asp Val 
                485                 490                 495     


Lys Gly Asn Leu Leu Lys Met Met Asn Asp Ser Met Ala Lys Lys Thr 
            500                 505                 510         


Ser Gly Asn Ala Phe Ile Gly Lys Lys Met Phe Gln Ile Ser Asp Lys 
        515                 520                 525             


Asn Lys Thr Asn Pro Ile Glu Ile Pro Ile Lys Gln Thr Ile Pro Asn 
    530                 535                 540                 


Phe Phe Phe Gly Arg Asp Thr Ala Glu Asp Tyr Asp Asp Leu Asp Tyr 
545                 550                 555                 560 


<210>  72
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - Optimized DNA sequence 
       encoding the nucleic acid sequence encoding NP antigen

<400>  72
atgtccaaca tggacatcga cggcatgaac accggcacca tcgacaagac ccccgaggag       60

atcacctccg gcacctccgg caccacccgc cccatcatcc gccccgccac cctggccccc      120

ccctccaaca agcgcacccg caacccctcc cccgagcgcg ccaccacctc ctccgaggac      180

gacgtgggcc gcaaggccca gaagaagcag acccccaccg agatcaagaa gtccgtgtac      240

aacatggtgg tgaagctggg cgagttctac aaccagatga tggtgaaggc cggcctgaac      300

gacgacatgg agcgcaacct gatccagaac gcccacgccg tggagcgcat cctgctggcc      360

gccaccgacg acaagaagac cgagttccag aagaagaaga acgcccgcga cgtgaaggag      420

ggcaaggagg agatcgacca caacaagacc ggcggcacct tctacaagat ggtgcgcgac      480

gacaagacca tctacttctc ccccatccgc atcaccttcc tgaaggagga ggtgaagacc      540

atgtacaaga ccaccatggg ctccgacggc ttctccggcc tgaaccacat catgatcggc      600

cactcccaga tgaacgacgt gtgcttccag cgctccaagg ccctgaagcg cgtgggcctg      660

gacccctccc tgatctccac cttcgccggc tccaccgtgc cccgccgctc cggcgccacc      720

ggcgtggcca tcaagggcgg cggcaccctg gtggccgagg ccatccgctt catcggccgc      780

gccatggccg accgcggcct gctgcgcgac atcaaggcca agaccgccta cgagaagatc      840

ctgctgaacc tgaagaacaa gtgctccgcc ccccagcaga aggccctggt ggaccaggtg      900

atcggctccc gcaaccccgg catcgccgac atcgaggacc tgaccctgct ggcccgctcc      960

atggtggtgg tgcgcccctc cgtggcctcc aaggtggtgc tgcccatctc catctacgcc     1020

aagatccccc agctgggctt caacgtggag gagtactcca tggtgggcta cgaggccatg     1080

gccctgtaca acatggccac ccccgtgtcc atcctgcgca tgggcgacga cgccaaggac     1140

aagtcccagc tgttcttcat gtcctgcttc ggcgccgcct acgaggacct gcgcgtgctg     1200

tccgccctga ccggcaccga gttcaagccc cgctccgccc tgaagtgcaa gggcttccac     1260

gtgcccgcca aggagcaggt ggagggcatg ggcgccgccc tgatgtccat caagctgcag     1320

ttctgggccc ccatgacccg ctccggcggc aacgaggtgg gcggcgacgg cggctccggc     1380

cagatctcct gctcccccgt gttcgccgtg gagcgcccca tcgccctgtc caagcaggcc     1440

gtgcgccgca tgctgtccat gaacatcgag ggccgcgacg ccgacgtgaa gggcaacctg     1500

ctgaagatga tgaacgactc catggccaag aagacctccg gcaacgcctt catcggcaag     1560

aagatgttcc agatctccga caagaacaag accaacccca tcgagatccc catcaagcag     1620

accatcccca acttcttctt cggccgcgac accgccgagg actacgacga cctggactac     1680


<210>  73
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       NP antigen Amino Acid sequence

<400>  73

Met Ser Asn Met Asp Ile Asp Gly Ile Asn Thr Gly Thr Ile Asp Lys 
1               5                   10                  15      


Thr Pro Glu Glu Ile Thr Ser Gly Thr Ser Gly Thr Thr Arg Pro Ile 
            20                  25                  30          


Ile Arg Pro Ala Thr Leu Ala Pro Pro Ser Asn Lys Arg Thr Arg Asn 
        35                  40                  45              


Pro Ser Pro Glu Arg Ala Thr Thr Ser Ser Glu Asp Asp Val Gly Arg 
    50                  55                  60                  


Lys Thr Gln Lys Lys Gln Thr Pro Thr Glu Ile Lys Lys Ser Val Tyr 
65                  70                  75                  80  


Asn Met Val Val Lys Leu Gly Glu Phe Tyr Asn Gln Met Met Val Lys 
                85                  90                  95      


Ala Gly Leu Asn Asp Asp Met Glu Arg Asn Leu Ile Gln Asn Ala Tyr 
            100                 105                 110         


Ala Val Glu Arg Ile Leu Leu Ala Ala Thr Asp Asp Lys Lys Thr Glu 
        115                 120                 125             


Phe Gln Lys Lys Lys Asn Ala Arg Asp Val Lys Glu Gly Lys Glu Glu 
    130                 135                 140                 


Ile Asp His Asn Lys Thr Gly Gly Thr Phe Tyr Lys Met Val Arg Asp 
145                 150                 155                 160 


Asp Lys Thr Ile Tyr Phe Ser Pro Ile Arg Ile Thr Phe Leu Lys Glu 
                165                 170                 175     


Glu Val Lys Thr Met Tyr Lys Thr Thr Met Gly Ser Asp Gly Phe Ser 
            180                 185                 190         


Gly Leu Asn His Ile Met Ile Gly His Ser Gln Met Asn Asp Val Cys 
        195                 200                 205             


Phe Gln Arg Ser Lys Ala Leu Lys Arg Val Gly Leu Asp Pro Ser Leu 
    210                 215                 220                 


Ile Ser Thr Phe Ala Gly Ser Thr Val Pro Arg Arg Ser Gly Ala Thr 
225                 230                 235                 240 


Gly Val Ala Ile Lys Gly Gly Gly Thr Leu Val Ala Glu Ala Ile Arg 
                245                 250                 255     


Phe Ile Gly Arg Ala Met Ala Asp Arg Gly Leu Leu Arg Asp Ile Lys 
            260                 265                 270         


Ala Lys Thr Ala Tyr Glu Lys Ile Leu Leu Asn Leu Lys Asn Lys Cys 
        275                 280                 285             


Ser Ala Pro Gln Gln Lys Ala Leu Val Asp Gln Val Ile Gly Ser Arg 
    290                 295                 300                 


Asn Pro Gly Ile Ala Asp Ile Glu Asp Leu Thr Leu Leu Ala Arg Ser 
305                 310                 315                 320 


Met Val Val Val Arg Pro Ser Val Ala Ser Lys Val Val Leu Pro Ile 
                325                 330                 335     


Ser Ile Tyr Ala Lys Ile Pro Gln Leu Gly Phe Asn Val Glu Glu Tyr 
            340                 345                 350         


Ser Met Val Gly Tyr Glu Ala Met Ala Leu Tyr Asn Met Ala Thr Pro 
        355                 360                 365             


Val Ser Ile Leu Arg Met Gly Asp Asp Ala Lys Asp Lys Ser Gln Leu 
    370                 375                 380                 


Phe Phe Met Ser Cys Phe Gly Ala Ala Tyr Glu Asp Leu Arg Val Leu 
385                 390                 395                 400 


Ser Ala Leu Thr Gly Thr Glu Phe Lys Pro Arg Ser Ala Leu Lys Cys 
                405                 410                 415     


Lys Gly Phe His Val Pro Ala Lys Glu Gln Val Glu Gly Met Gly Ala 
            420                 425                 430         


Ala Leu Met Ser Ile Lys Leu Gln Phe Trp Ala Pro Met Thr Arg Ser 
        435                 440                 445             


Gly Gly Asn Glu Ala Gly Gly Asp Gly Gly Ser Gly Gln Ile Ser Cys 
    450                 455                 460                 


Ser Pro Val Phe Ala Val Glu Arg Pro Ile Ala Leu Ser Lys Gln Ala 
465                 470                 475                 480 


Val Arg Arg Met Leu Ser Met Asn Ile Glu Gly Arg Asp Ala Asp Val 
                485                 490                 495     


Lys Gly Asn Leu Leu Lys Met Met Asn Asp Ser Met Ala Lys Lys Thr 
            500                 505                 510         


Ser Gly Asn Ala Phe Ile Gly Lys Lys Met Phe Gln Ile Ser Asp Lys 
        515                 520                 525             


Asn Lys Thr Asn Pro Ile Glu Ile Pro Ile Lys Gln Thr Ile Pro Asn 
    530                 535                 540                 


Phe Phe Phe Gly Arg Asp Thr Ala Glu Asp Tyr Asp Asp Leu Asp Tyr 
545                 550                 555                 560 


<210>  74
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       Optimized DNA sequence encoding the nucleic acid sequence 
       encoding NP antigen

<400>  74
atgtccaaca tggacatcga cggcatcaac accggcacca tcgacaagac ccccgaggag       60

atcacctccg gcacctccgg caccacccgc cccatcatcc gccccgccac cctggccccc      120

ccctccaaca agcgcacccg caacccctcc cccgagcgcg ccaccacctc ctccgaggac      180

gacgtgggcc gcaagaccca gaagaagcag acccccaccg agatcaagaa gtccgtgtac      240

aacatggtgg tgaagctggg cgagttctac aaccagatga tggtgaaggc cggcctgaac      300

gacgacatgg agcgcaacct gatccagaac gcctacgccg tggagcgcat cctgctggcc      360

gccaccgacg acaagaagac cgagttccag aagaagaaga acgcccgcga cgtgaaggag      420

ggcaaggagg agatcgacca caacaagacc ggcggcacct tctacaagat ggtgcgcgac      480

gacaagacca tctacttctc ccccatccgc atcaccttcc tgaaggagga ggtgaagacc      540

atgtacaaga ccaccatggg ctccgacggc ttctccggcc tgaaccacat catgatcggc      600

cactcccaga tgaacgacgt gtgcttccag cgctccaagg ccctgaagcg cgtgggcctg      660

gacccctccc tgatctccac cttcgccggc tccaccgtgc cccgccgctc cggcgccacc      720

ggcgtggcca tcaagggcgg cggcaccctg gtggccgagg ccatccgctt catcggccgc      780

gccatggccg accgcggcct gctgcgcgac atcaaggcca agaccgccta cgagaagatc      840

ctgctgaacc tgaagaacaa gtgctccgcc ccccagcaga aggccctggt ggaccaggtg      900

atcggctccc gcaaccccgg catcgccgac atcgaggacc tgaccctgct ggcccgctcc      960

atggtggtgg tgcgcccctc cgtggcctcc aaggtggtgc tgcccatctc catctacgcc     1020

aagatccccc agctgggctt caacgtggag gagtactcca tggtgggcta cgaggccatg     1080

gccctgtaca acatggccac ccccgtgtcc atcctgcgca tgggcgacga cgccaaggac     1140

aagtcccagc tgttcttcat gtcctgcttc ggcgccgcct acgaggacct gcgcgtgctg     1200

tccgccctga ccggcaccga gttcaagccc cgctccgccc tgaagtgcaa gggcttccac     1260

gtgcccgcca aggagcaggt ggagggcatg ggcgccgccc tgatgtccat caagctgcag     1320

ttctgggccc ccatgacccg ctccggcggc aacgaggccg gcggcgacgg cggctccggc     1380

cagatctcct gctcccccgt gttcgccgtg gagcgcccca tcgccctgtc caagcaggcc     1440

gtgcgccgca tgctgtccat gaacatcgag ggccgcgacg ccgacgtgaa gggcaacctg     1500

ctgaagatga tgaacgactc catggccaag aagacctccg gcaacgcctt catcggcaag     1560

aagatgttcc agatctccga caagaacaag accaacccca tcgagatccc catcaagcag     1620

accatcccca acttcttctt cggccgcgac accgccgagg actacgacga cctggactac     1680


<210>  75
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - NP antigen Amino Acid sequence

<400>  75

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Val Ser Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Leu Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val 
            340                 345                 350         


Ile Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Ala Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Asn Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  76
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  76
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccggcgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc cgcatggtgt ccggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gactacgagg gccgcctgat ccagaactcc      180

atcaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaaccg ctacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgccgc      300

gacggcaagt gggtgcgcga gctgatcctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga ggacgccacc gccggcctga cccacctgat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcgtggg caccatggtg atggagctga tccgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgcc gcacccgcat cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggcctgg ccgtggcctc cggctacgac ttcgagcgcg agggctactc cctggtgggc      900

atcgacccct tccgcctgct gcagaactcc caggtgttct ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcacc cgcgtgatcc cccgcggcca gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggaggcca tggactccaa caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc catccagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagcgcgcca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcaccgaga tcatccgcat gatggagtcc gcccgccccg aggacgtgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccaccaacc ccatcgtgcc ctccttcgac     1440

atgaacaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  77
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - NP antigen Amino Acid sequence


<220>
<221>  misc_feature
<222>  (272)..(272)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Val Ser Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Asn Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ser Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Leu Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Ile Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala Xaa 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Lys Gly Thr Lys Met 
            340                 345                 350         


Val Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Ala Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Val Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Asn Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  78
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen


<220>
<221>  misc_feature
<222>  (814)..(816)
<223>  any nucleotide

<400>  78
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccggcgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc cgcatggtgt ccggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gacaacgagg gccgcctgat ccagaactcc      180

atcaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaaccg ctacctggag      240

gagcacccct cctccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgccgc      300

gacggcaagt gggtgcgcga gctgatcctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga ggacgccacc gccggcctga cccacctgat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcatcgg caccatggtg atggagctgg tgcgcatgat caagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgcc gcacccgcat cgcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catgatggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gccnnnaagt cctgcctgcc cgcctgcgtg      840

tacggcctgg ccgtggcctc cggctacgac ttcgagcgcg agggctactc cctggtgggc      900

atcgacccct tccgcctgct gcagaactcc caggtgttct ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat caagggcacc aagatggtgc cccgcggcca gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggaggcca tggactccaa caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccaggtgtc cgtgcagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagcgcgcca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcaccgaga tcatccgcat gatggagtcc gcccgccccg aggacgtgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacgagaag gccaccaacc ccatcgtgcc ctccttcgac     1440

atgaacaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  79
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - NP antigen Amino Acid sequence

<400>  79

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Val Ser Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Asn Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Leu Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Ile Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Val Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Val Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Val Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Met 
            340                 345                 350         


Val Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Ala Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Lys Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  80
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding NP antigen

<400>  80
atggcctccc agggcaccaa gcgctcctac gagcagatgg agaccggcgg cgagcgccag       60

aacgccaccg agatccgcgc ctccgtgggc cgcatggtgt ccggcatcgg ccgcttctac      120

atccagatgt gcaccgagct gaagctgtcc gacaacgagg gccgcctgat ccagaactcc      180

atcaccatcg agcgcatggt gctgtccgcc ttcgacgagc gccgcaaccg ctacctggag      240

gagcacccct ccgccggcaa ggaccccaag aagaccggcg gccccatcta ccgccgccgc      300

gacggcaagt gggtgcgcga gctgatcctg tacgacaagg aggagatccg ccgcatctgg      360

cgccaggcca acaacggcga ggacgccacc gccggcctga cccacctgat gatctggcac      420

tccaacctga acgacgccac ctaccagcgc acccgcgccc tggtgcgcac cggcatggac      480

ccccgcatgt gctccctgat gcagggctcc accctgcccc gccgctccgg cgccgccggc      540

gccgccgtga agggcatcgg caccatggtg atggagctga tccgcatggt gaagcgcggc      600

atcaacgacc gcaacttctg gcgcggcgag aacggccgcc gcacccgcgt ggcctacgag      660

cgcatgtgca acatcctgaa gggcaagttc cagaccgccg cccagcgcgc catggtggac      720

caggtgcgcg agtcccgcaa ccccggcaac gccgagatcg aggacctgat cttcctggcc      780

cgctccgccc tgatcctgcg cggctccgtg gcccacaagt cctgcctgcc cgcctgcgtg      840

tacggcctgg ccgtggcctc cggctacgac ttcgagcgcg agggctactc cctggtgggc      900

atcgacccct tccgcctgct gcagaactcc caggtgttct ccctgatccg ccccaacgag      960

aaccccgccc acaagtccca gctggtgtgg atggcctgcc actccgccgc cttcgaggac     1020

ctgcgcgtgt cctccttcat ccgcggcacc cgcatggtgc cccgcggcca gctgtccacc     1080

cgcggcgtgc agatcgcctc caacgagaac atggaggcca tggactccaa caccctggag     1140

ctgcgctccc gctactgggc catccgcacc cgctccggcg gcaacaccaa ccagcagcgc     1200

gcctccgccg gccagatctc cgtgcagccc accttctccg tgcagcgcaa cctgcccttc     1260

gagcgcgcca ccatcatggc cgccttcacc ggcaacaccg agggccgcac ctccgacatg     1320

cgcaccgaga tcatccgcat gatggagtcc gcccgccccg aggacgtgtc cttccagggc     1380

cgcggcgtgt tcgagctgtc cgacaagaag gccaccaacc ccatcgtgcc ctccttcgac     1440

atgtccaacg agggctccta cttcttcggc gacaacgccg aggagtacga caac           1494


<210>  81
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - M2 ion channel antigen Amino Acid sequence

<400>  81

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Asp Ser Ser Asp Pro Leu Val Ile Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Leu Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  82
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1918 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  82
atgtccctgc tgaccgaggt ggagaccccc acccgcaacg agtggggctg ccgctgcaac       60

gactcctccg accccctggt gatcgccgcc tccatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgcc gcctgaagta cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtaccg caaggagcag      240

cagtccgccg tggacgtgga cgacggccac ttcgtgaaca tcgagctgga g               291


<210>  83
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - M2 ion channel antigen Amino Acid sequence

<400>  83

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Asp Ser Ser Asp Pro Leu Val Val Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Phe Phe Lys His Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Ala Asp Asp Ser His Phe Val Ser Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  84
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1957 H2N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  84
atgtccctgc tgaccgaggt ggagaccccc atccgcaacg agtggggctg ccgctgcaac       60

gactcctccg accccctggt ggtggccgcc tccatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgct tcttcaagca cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtaccg caaggagcag      240

cagtccgccg tggacgccga cgactcccac ttcgtgtcca tcgagctgga g               291


<210>  85
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - M2 ion channel antigen Amino Acid sequence

<400>  85

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Asp Ser Ser Asp Pro Leu Val Val Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Phe Phe Glu His Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Ala Asp Asp Ser His Phe Val Ser Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  86
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1968 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  86
atgtccctgc tgaccgaggt ggagaccccc atccgcaacg agtggggctg ccgctgcaac       60

gactcctccg accccctggt ggtggccgcc tccatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgct tcttcgagca cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtaccg caaggagcag      240

cagtccgccg tggacgccga cgactcccac ttcgtgtcca tcgagctgga g               291


<210>  87
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - M2 ion channel antigen Amino Acid sequence

<400>  87

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Asp Ser Ser Asp Pro Leu Val Val Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Leu Phe Lys His Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Ala Asp Asp Ser His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  88
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1977 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  88
atgtccctgc tgaccgaggt ggagaccccc atccgcaacg agtggggctg ccgctgcaac       60

gactcctccg accccctggt ggtggccgcc tccatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgcc tgttcaagca cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtaccg caaggagcag      240

cagaacgccg tggacgccga cgactcccac ttcgtgaaca tcgagctgga g               291


<210>  89
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - M2 ion channel antigen Amino Acid sequence

<400>  89

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Asp Ser Ser Asp Pro Leu Val Val Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Val His Leu Ile Leu Trp Ile Ile Asp Arg Leu Phe Ser 
        35                  40                  45              


Lys Ser Ile Tyr Arg Ile Phe Lys His Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Glu Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Ala Asp Asp Asp His Phe Val Ser Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  90
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2007 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  90
atgtccctgc tgaccgaggt ggagaccccc atccgcaacg agtggggctg ccgctgcaac       60

gactcctccg accccctggt ggtggccgcc tccatcatcg gcatcgtgca cctgatcctg      120

tggatcatcg accgcctgtt ctccaagtcc atctaccgca tcttcaagca cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtaccg cgaggagcag      240

cagaacgccg tggacgccga cgacgaccac ttcgtgtcca tcgagctgga g               291


<210>  91
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - M2 ion channel antigen Amino Acid sequence

<400>  91

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Ser Glu Trp Glu 
1               5                   10                  15      


Cys Arg Cys Ser Asp Ser Ser Asp Pro Leu Val Ile Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Thr Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Gln Gln Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  92
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2009 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  92
atgtccctgc tgaccgaggt ggagaccccc acccgctccg agtgggagtg ccgctgctcc       60

gactcctccg accccctggt gatcgccgcc aacatcatcg gcatcctgca cctgatcctg      120

tggatcaccg accgcctgtt cttcaagtgc atctaccgcc gcttcaagta cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtacca gcaggagcag      240

cagtccgccg tggacgtgga cgacggccac ttcgtgaaca tcgagctgga g               291


<210>  93
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - M2 ion channel antigen Amino Acid sequence

<400>  93

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Ser Glu Trp Glu 
1               5                   10                  15      


Cys Arg Cys Ser Gly Ser Ser Asp Pro Leu Val Ile Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Thr Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Gln Gln Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  94
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H1N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  94
atgtccctgc tgaccgaggt ggagaccccc acccgctccg agtgggagtg ccgctgctcc       60

ggctcctccg accccctggt gatcgccgcc aacatcatcg gcatcctgca cctgatcctg      120

tggatcaccg accgcctgtt cttcaagtgc atctaccgcc gcttcaagta cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtacca gcaggagcag      240

cagtccgccg tggacgtgga cgacggccac ttcgtgaaca tcgagctgga g               291


<210>  95
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - M2 ion channel antigen Amino Acid sequence

<400>  95

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Asp Ser Ser Asp Pro Leu Ile Val Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Val Cys Arg Leu Phe Lys His Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Ala Asp Asp Ser His Phe Val Ser Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  96
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H3N2 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  96
atgtccctgc tgaccgaggt ggagaccccc atccgcaacg agtggggctg ccgctgcaac       60

gactcctccg accccctgat cgtggccgcc aacatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc gtgtgccgcc tgttcaagca cggcctgaag      180

cgcggcccct ccaccgaggg cgtgcccgag tccatgcgcg aggagtaccg caaggagcag      240

cagaacgccg tggacgccga cgactcccac ttcgtgtcca tcgagctgga g               291


<210>  97
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - M2 ion channel antigen 
       Amino Acid sequence

<400>  97

Met Leu Glu Pro Phe Gln Ile Leu Thr Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Lys 
            20                  25                  30          


Arg Gly Ile Asn Met Lys Ile Arg Ile Lys Gly Pro Asn Lys Glu Thr 
        35                  40                  45              


Ile Thr Arg Glu Val Ser Ile Leu Arg His Ser Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Glu Val Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Asn Asp His Ile Ile Ile Glu Gly Leu Ser Ala Glu Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Ile Glu Glu Leu His 
            100                 105                 


<210>  98
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 Influenza B (Victoria lineage) - Optimized DNA sequence 
       encoding the nucleic acid sequence encoding M2 ion channel 
       antigen

<400>  98
atgctggagc ccttccagat cctgaccatc tgctccttca tcctgtccgc cctgcacttc       60

atggcctgga ccatcggcca cctgaaccag atcaagcgcg gcatcaacat gaagatccgc      120

atcaagggcc ccaacaagga gaccatcacc cgcgaggtgt ccatcctgcg ccactcctac      180

cagaaggaga tccaggccaa ggagaccatg aaggaggtgc tgtccgacaa catggaggtg      240

ctgaacgacc acatcatcat cgagggcctg tccgccgagg agatcatcaa gatgggcgag      300

accgtgctgg agatcgagga gctgcac                                          327


<210>  99
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       M2 ion channel antigen Amino Acid sequence

<400>  99

Met Phe Glu Pro Phe Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Lys 
            20                  25                  30          


Arg Gly Val Asn Met Lys Ile Arg Ile Lys Gly Pro Asn Lys Glu Thr 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Ser Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Ala Met Lys Glu Val Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Ser Asp His Ile Val Ile Glu Gly Leu Ser Ala Glu Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Ser His 
            100                 105                 


<210>  100
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 Influenza B (Yamagata lineage) - Sequence only on GISAID - 
       Optimized DNA sequence encoding the nucleic acid sequence 
       encoding M2 ion channel antigen

<400>  100
atgttcgagc ccttccagat cctgtccatc tgctccttca tcctgtccgc cctgcacttc       60

atggcctgga ccatcggcca cctgaaccag atcaagcgcg gcgtgaacat gaagatccgc      120

atcaagggcc ccaacaagga gaccatcaac cgcgaggtgt ccatcctgcg ccactcctac      180

cagaaggaga tccaggccaa ggaggccatg aaggaggtgc tgtccgacaa catggaggtg      240

ctgtccgacc acatcgtgat cgagggcctg tccgccgagg agatcatcaa gatgggcgag      300

accgtgctgg aggtggagga gtcccac                                          327


<210>  101
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - M2 ion channel antigen Amino Acid sequence

<400>  101

Met Ser Leu Leu Thr Glu Val Glu Thr Leu Thr Lys Thr Gly Trp Glu 
1               5                   10                  15      


Cys Asn Cys Ser Gly Ser Ser Asp Pro Leu Gly Val Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Arg Tyr Gly Leu Lys Gly Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Ile Pro Glu Ser Met Arg Glu Glu Tyr Arg Gln Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  102
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2015 H5N1 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  102
atgtccctgc tgaccgaggt ggagaccctg accaagaccg gctgggagtg caactgctcc       60

ggctcctccg accccctggg cgtggccgcc aacatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgcc gcttccgcta cggcctgaag      180

ggcggcccct ccaccgaggg catccccgag tccatgcgcg aggagtaccg ccaggagcag      240

cagaacgccg tggacgtgga cgacggccac ttcgtgaaca tcgagctgga g               291


<210>  103
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - M2 ion channel antigen Amino Acid sequence

<400>  103

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Thr Gly Trp Glu 
1               5                   10                  15      


Cys Asn Cys Ser Gly Ser Ser Asp Pro Phe Val Val Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Met Pro Glu Ser Met Arg Glu Glu Tyr Arg Gln Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Lys 
    


<210>  104
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2017 H7N9 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  104
atgtccctgc tgaccgaggt ggagaccccc acccgcaccg gctgggagtg caactgctcc       60

ggctcctccg accccttcgt ggtggccgcc aacatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgcc gcttcaagta cggcctgaag      180

cgcggcccct ccaccgaggg catgcccgag tccatgcgcg aggagtaccg ccaggagcag      240

cagaacgccg tggacgtgga cgacggccac ttcgtgaaca tcgagctgaa g               291


<210>  105
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - M2 ion channel antigen Amino Acid sequence

<400>  105

Met Ser Leu Leu Thr Glu Val Glu Thr Leu Thr Lys Thr Gly Trp Glu 
1               5                   10                  15      


Cys Asn Cys Ser Gly Ser Ser Asp Pro Leu Val Val Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Met Pro Glu Ser Met Arg Glu Glu Tyr Arg Gln Glu Gln 
65                  70                  75                  80  


Gln Asn Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Lys 
    


<210>  106
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2013 H10N8 - Optimized DNA sequence encoding the nucleic acid 
       sequence encoding M2 ion channel antigen

<400>  106
atgtccctgc tgaccgaggt ggagaccctg accaagaccg gctgggagtg caactgctcc       60

ggctcctccg accccctggt ggtggccgcc aacatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accgcctgtt cttcaagtgc atctaccgcc gcttcaagta cggcctgaag      180

cgcggcccct ccaccgaggg catgcccgag tccatgcgcg aggagtaccg ccaggagcag      240

cagaacgccg tggacgtgga cgacggccac ttcgtgaaca tcgagctgaa g               291


<210>  107
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M1 antigen Amino Acid sequence

<400>  107

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Ser Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Ile 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Arg Ala 
                85                  90                  95      


Val Lys Leu Tyr Lys Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Val Ser Leu Ser Tyr Ser Thr Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Thr Val Thr Thr Glu Ala Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Ala Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Val 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Asn Lys 
        195                 200                 205             


Thr Arg Gln Met Val His Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Arg Asp Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  108
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized DNA sequence encoding the nucleic acid sequence 
       encoding M1 antigen

<400>  108
atgtccctgc tgaccgaggt ggagacctac gtgctgtcca tcatcccctc cggccccctg       60

aaggccgaga tcgcccagcg cctggagtcc gtgttcgccg gcaagaacac cgacctggag      120

gccctgatgg agtggctgaa gacccgcccc atcctgtccc ccctgaccaa gggcatcctg      180

ggcttcgtgt tcaccctgac cgtgccctcc gagcgcggcc tgcagcgccg ccgcttcatc      240

cagaacgccc tgaacggcaa cggcgacccc aacaacatgg accgcgccgt gaagctgtac      300

aagaagctga agcgcgagat caccttccac ggcgccaagg aggtgtccct gtcctactcc      360

accggcgccc tggcctcctg catgggcctg atctacaacc gcatgggcac cgtgaccacc      420

gaggccgcct tcggcctggt gtgcgccacc tgcgagcaga tcgccgactc ccagcaccgc      480

tcccaccgcc agatggccac caccaccaac cccctgatcc gccacgagaa ccgcatggtg      540

ctggcctcca ccaccgccaa ggccatggag caggtggccg gctcctccga gcaggccgcc      600

gaggccatgg aggtggccaa caagacccgc cagatggtgc acgccatgcg caccatcggc      660

acccacccct cctcctccgc cggcctgcgc gacgacctgc tggagaacct gcaggcctac      720

cagaagcgca tgggcgtgca gatgcagcgg ttcaag                                756


<210>  109
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA amino acid sequence

<400>  109

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly Tyr Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Val Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asn Gln Arg Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Glu Cys Asp Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg 
        515                 520                 525             


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
    530                 535                 540                 


Thr Phe Leu Ser Gly Arg Leu Val Pro Arg Gly Ser Gly His His His 
545                 550                 555                 560 


His His His 
            


<210>  110
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen1 HA SS amino acid sequence

<400>  110

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Gly Ser Gly Asp Ala Lys Cys 
    50                  55                  60                  


Gln Thr Pro Gln Gly Ala Ile Asn Ser Ser Leu Pro Phe Gln Asn Val 
65                  70                  75                  80  


His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys 
                85                  90                  95      


Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln Arg Glu Thr Arg 
            100                 105                 110         


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly 
        115                 120                 125             


Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser 
    130                 135                 140                 


Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile 
145                 150                 155                 160 


Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr 
                165                 170                 175     


Ala Val Gly Lys Glu Phe Asn Lys Leu Glu Arg Arg Met Glu Asn Leu 
            180                 185                 190         


Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala 
        195                 200                 205             


Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
    210                 215                 220                 


Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn 
225                 230                 235                 240 


Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
                245                 250                 255     


Asn Asn Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro 
            260                 265                 270         


Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Pro Gly 
        275                 280                 285             


Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
    290                 295                 300                 


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Ser Gly Arg Leu 
305                 310                 315                 320 


Val Pro Arg Gly Ser Gly His His His His His His 
                325                 330         


<210>  111
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen2 HA SS amino acid sequence

<400>  111

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Gly Ser Gly Asp Ala Lys Cys 
    50                  55                  60                  


Gln Thr Pro Gln Gly Ala Ile Asn Ser Ser Leu Pro Phe Gln Asn Val 
65                  70                  75                  80  


His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser Ala Lys 
                85                  90                  95      


Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln Arg Glu Thr Arg 
            100                 105                 110         


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly 
        115                 120                 125             


Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser 
    130                 135                 140                 


Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile 
145                 150                 155                 160 


Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr 
                165                 170                 175     


Ala Thr Gly Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
            180                 185                 190         


Ile Ile Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Asn Gly 
        195                 200                 205             


Thr Gly Gly Gly Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg 
    210                 215                 220                 


Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile 
225                 230                 235                 240 


Lys Gln Leu Gln Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu 
                245                 250                 255     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            260                 265                 270         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        275                 280                 285             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    290                 295                 300                 


Asn Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
305                 310                 315                 320 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Pro Gly Ser 
                325                 330                 335     


Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
            340                 345                 350         


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Ser Gly Arg Leu Val 
        355                 360                 365             


Pro Arg Gly Ser Gly His His His His His His 
    370                 375                 


<210>  112
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen3 HA SS amino acid sequence

<400>  112

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Trp Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Gly Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Ile Ile 
    130                 135                 140                 


Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Asn Gly Thr Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
                165                 170                 175     


Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
            180                 185                 190         


Leu Gln Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg 
        195                 200                 205             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val 
    210                 215                 220                 


Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe 
225                 230                 235                 240 


Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys Asn 
                245                 250                 255     


Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg 
            260                 265                 270         


Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
        275                 280                 285             


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
    290                 295                 300                 


Phe Leu Ser Gly Arg Leu Val Pro Arg Gly Ser Gly His His His His 
305                 310                 315                 320 


His His 
        


<210>  113
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen4 HA SS amino acid sequence

<400>  113

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Gly Asp Pro Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Ile Ile 
    130                 135                 140                 


Tyr Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Asn Gly Thr Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
                165                 170                 175     


Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
            180                 185                 190         


Leu Gln Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg 
        195                 200                 205             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val 
    210                 215                 220                 


Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe 
225                 230                 235                 240 


Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys Asn 
                245                 250                 255     


Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg 
            260                 265                 270         


Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
        275                 280                 285             


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
    290                 295                 300                 


Phe Leu Ser Gly Arg Leu Val Pro Arg Gly Ser Gly His His His His 
305                 310                 315                 320 


His His 
        


<210>  114
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen5 HA SS amino acid sequence

<400>  114

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val Leu Leu Glu 
    130                 135                 140                 


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
145                 150                 155                 160 


Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser 
            180                 185                 190         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys 
        195                 200                 205             


Leu Asn Arg Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
    210                 215                 220                 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
225                 230                 235                 240 


Leu Ser Thr Phe Leu Ser Gly Arg Leu Val Pro Arg Gly Ser Gly His 
                245                 250                 255     


His His His His His 
            260     


<210>  115
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen6 HA SS 1 amino acid sequence

<400>  115

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val Leu Leu Leu Asn Gln 
    130                 135                 140                 


Trp Thr Leu Leu Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
145                 150                 155                 160 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
                165                 170                 175     


Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val Lys 
            180                 185                 190         


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
        195                 200                 205             


Arg Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg 
    210                 215                 220                 


Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser 
225                 230                 235                 240 


Thr Phe Leu Ser Gly Arg Leu Val Pro Arg Gly Ser Gly His His His 
                245                 250                 255     


His His His 
            


<210>  116
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gen6 HA SS 2 amino acid sequence

<400>  116

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val Leu Leu Leu 
    130                 135                 140                 


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
145                 150                 155                 160 


Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser 
            180                 185                 190         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys 
        195                 200                 205             


Leu Asn Arg Glu Lys Ile Asp Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
    210                 215                 220                 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
225                 230                 235                 240 


Leu Ser Thr Phe Leu Ser Gly Arg Leu Val Pro Arg Gly Ser Gly His 
                245                 250                 255     


His His His His His 
            260     


<210>  117
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FL HA amino acid sequence

<400>  117

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Leu Cys Leu Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Asn Cys Ser Val Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Leu Leu Ile Ser Lys Glu Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Lys Pro Asn Pro Glu Asn Gly Thr Cys Tyr Pro Gly His Phe 
            100                 105                 110         


Ala Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Val Thr Gly Val Ser Ala Ser Cys Ser His Asn Gly Glu Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Asn 
                165                 170                 175     


Leu Ser Lys Ser Tyr Ala Asn Asn Lys Glu Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Pro Asn Ile Gly Asp Gln Lys Ala Leu Tyr 
        195                 200                 205             


His Thr Glu Asn Ala Tyr Val Ser Val Val Ser Ser His Tyr Ser Arg 
    210                 215                 220                 


Lys Phe Thr Pro Glu Ile Ala Lys Arg Pro Lys Val Arg Asp Gln Glu 
225                 230                 235                 240 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Arg Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Asn Ser Asn Ala Pro Met 
        275                 280                 285             


Asp Lys Cys Lys Ala Lys Cys Gln Thr Pro Gln Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Phe Gln Asn Val His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Cys Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Glu Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Arg Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Ile 
            420                 425                 430         


Asp Ile Trp Cys Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asn Asp Glu Cys Met Glu Ser Val Lys 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  118
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA 2759 amino acid sequence

<400>  118

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Glu Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Ser Thr Ala 
    130                 135                 140                 


Thr Gly Lys Glu Gly Asn Lys Ser Glu Arg Met Lys Gln Ile Glu Asp 
145                 150                 155                 160 


Lys Ile Glu Glu Ile Glu Ser Lys Gln Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Val Tyr Gln Ile Glu Gly Arg His His His His 
            260                 265                 270         


His His His 
        275 


<210>  119
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA 4157 amino acid sequence

<400>  119

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Glu Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Ser Thr Ala 
    130                 135                 140                 


Thr Gly Lys Glu Gly Asn Lys Ser Glu Arg Met Lys Gln Ile Glu Asp 
145                 150                 155                 160 


Lys Ile Glu Glu Ile Glu Ser Lys Gln Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Arg Ser 
                245                 250                 255     


Leu Val Pro Arg Gly Ser Pro Gly His His His His His His 
            260                 265                 270 


<210>  120
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA 4454 amino acid sequence

<400>  120

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Lys Pro Ser Lys Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Thr Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Tyr Thr Ala 
    130                 135                 140                 


Ile Gly Lys Glu Tyr Asn Lys Ser Glu Arg Met Lys Gln Ile Glu Asp 
145                 150                 155                 160 


Lys Ile Glu Glu Ile Glu Ser Lys Gln Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Arg Ser 
                245                 250                 255     


Leu Val Pro Arg Gly Ser Pro Gly His His His His His His 
            260                 265                 270 


<210>  121
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA 4650 amino acid sequence

<400>  121

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Lys Pro Ser Lys Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Thr Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Tyr Thr Ala 
    130                 135                 140                 


Ile Gly Lys Glu Tyr Asn Lys Ser Glu Arg Arg Met Lys Gln Ile Glu 
145                 150                 155                 160 


Asp Lys Ile Glu Glu Ile Glu Ser Lys Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Arg Ser 
                245                 250                 255     


Leu Val Pro Arg Gly Ser Pro Gly His His His His His His 
            260                 265                 270 


<210>  122
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA 4900 amino acid sequence

<400>  122

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Lys Pro Ser Lys Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Thr Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Tyr Thr Ala 
    130                 135                 140                 


Ile Gly Cys Glu Tyr Asn Lys Ser Glu Arg Cys Met Lys Gln Ile Glu 
145                 150                 155                 160 


Asp Lys Ile Glu Glu Ile Glu Ser Lys Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Val Tyr Gln Ile Glu Gly Arg His His His His 
            260                 265                 270         


His His His 
        275 


<210>  123
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mini HA 4900 amino acid sequence

<400>  123

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Gly Gly Gly Gly Lys Tyr Val Cys Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Lys Pro Ser Lys Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Thr Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Tyr Thr Ala 
    130                 135                 140                 


Ile Gly Cys Glu Tyr Asn Lys Ser Glu Arg Cys Met Lys Gln Ile Glu 
145                 150                 155                 160 


Asp Lys Ile Glu Glu Ile Glu Ser Lys Ile Trp Cys Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Val Tyr Gln Ile Glu Gly Arg His His His His 
            260                 265                 270         


His His His 
        275 


<210>  124
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A California 04 2009 H1N1 amino acid sequence

<400>  124

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Tyr Val Lys Ser Thr Lys Leu 
    50                  55                  60                  


Arg Leu Ala Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala 
    130                 135                 140                 


Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn Leu Asn 
145                 150                 155                 160 


Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp 
    210                 215                 220                 


Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val 
            260                 265                 270         


Ala Ser Ser 
        275 


<210>  125
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Brisbane 59 2007 H1N1 amino acid sequence

<400>  125

Met Lys Val Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asn Ser His Asn Gly Lys Tyr Val Arg Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Gln Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala 
    130                 135                 140                 


Val Gly Lys Glu Phe Asn Lys Leu Glu Arg Arg Met Glu Asn Leu Asn 
145                 150                 155                 160 


Lys Lys Val Asp Asp Gly Phe Ile Asp Ile Trp Thr Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asp Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Val Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val 
            260                 265                 270         


Ala Ser Ser 
        275 


<210>  126
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A New Caledonia 20 1999 H1N1 amino acid sequence

<400>  126

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Tyr Val Arg Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala 
    130                 135                 140                 


Val Gly Lys Glu Phe Asn Lys Leu Glu Arg Arg Met Glu Asn Leu Asn 
145                 150                 155                 160 


Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asn 
    210                 215                 220                 


Asn Glu Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Val Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val 
            260                 265                 270         


Ala Ser Ser 
        275 


<210>  127
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Puerto Rico 8 1934 H1N1 amino acid sequence

<400>  127

Met Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Tyr Val Arg Ser Ala Lys Leu 
    50                  55                  60                  


Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly 
65                  70                  75                  80  


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met 
                85                  90                  95      


Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
            100                 105                 110         


Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly Ile Thr 
        115                 120                 125             


Asn Lys Val Asn Thr Val Ile Glu Lys Met Asn Ile Gln Phe Thr Ala 
    130                 135                 140                 


Val Gly Lys Glu Phe Asn Lys Leu Glu Lys Arg Met Glu Asn Leu Asn 
145                 150                 155                 160 


Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu 
                165                 170                 175     


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser 
            180                 185                 190         


Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys Asn Asn 
        195                 200                 205             


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp 
    210                 215                 220                 


Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Lys 
225                 230                 235                 240 


Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Val Asp Gly Val Lys 
                245                 250                 255     


Leu Glu Ser Met Gly Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val 
            260                 265                 270         


Ala Ser Ser 
        275 


<210>  128
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Vietnam 1203 2004 H5N1

<400>  128

Met Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Lys His Asn Gly Lys Tyr Val Lys Ser Asn Arg Leu Val 
    50                  55                  60                  


Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg Glu Arg Arg Arg Lys 
65                  70                  75                  80  


Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
                85                  90                  95      


Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln 
            100                 105                 110         


Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp 
        115                 120                 125             


Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln 
    130                 135                 140                 


Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu 
145                 150                 155                 160 


Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr 
                165                 170                 175     


Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe 
            180                 185                 190         


His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu 
        195                 200                 205             


Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His 
    210                 215                 220                 


Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp 
225                 230                 235                 240 


Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser 
                245                 250                 255     


Gly Val Lys Leu Glu Ser Ile Gly Ile Tyr Gln Ile Leu Ser Ile Tyr 
            260                 265                 270         


Ser Thr Val Ala Ser Ser 
        275             


<210>  129
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Hong Kong 1073 1999 H9N2 amino acid sequence

<400>  129

Met Glu Thr Ile Ser Leu Ile Thr Ile Leu Leu Val Val Thr Ala Ser 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Tyr Val Arg Val Asn Ser 
    50                  55                  60                  


Leu Lys Leu Ala Val Gly Leu Arg Asn Val Pro Ala Arg Ser Ser Arg 
65                  70                  75                  80  


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
                85                  90                  95      


Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln Gly Val 
            100                 105                 110         


Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Ile Asp Lys Ile 
        115                 120                 125             


Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln Tyr Glu 
    130                 135                 140                 


Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn Met Ile 
145                 150                 155                 160 


Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr Asn Ala 
                165                 170                 175     


Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His Asp 
            180                 185                 190         


Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu Gly Ser 
        195                 200                 205             


Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His Lys Cys 
    210                 215                 220                 


Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn Arg Arg 
225                 230                 235                 240 


Lys Tyr Arg Glu Glu Ser Arg Leu Glu Arg Gln Lys Ile Glu Gly Val 
                245                 250                 255     


Lys Leu Glu Ser Glu Gly Thr Tyr Lys Ile Leu Thr Ile Tyr Ser Thr 
            260                 265                 270         


Val Ala Ser Ser 
        275     


<210>  130
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Wisconsin 67 2005 H3N2 amino acid sequence

<400>  130

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
65                  70                  75                  80  


Asn Val Pro Glu Lys Gln Thr Gln Gly Ile Phe Gly Ala Ile Ala Gly 
                85                  90                  95      


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
            100                 105                 110         


Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys Ser 
        115                 120                 125             


Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile 
    130                 135                 140                 


Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
145                 150                 155                 160 


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
                165                 170                 175     


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
            180                 185                 190         


Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu 
        195                 200                 205             


Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly 
    210                 215                 220                 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
225                 230                 235                 240 


Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn 
                245                 250                 255     


Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp 
            260                 265                 270         


Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys 
        275                 280             


<210>  131
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Brisbane 10 2007 H3N2 amino acid sequence

<400>  131

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Thr 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Glu Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
65                  70                  75                  80  


Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala Gly 
                85                  90                  95      


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
            100                 105                 110         


Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys Ser 
        115                 120                 125             


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile 
    130                 135                 140                 


Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
145                 150                 155                 160 


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
                165                 170                 175     


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
            180                 185                 190         


Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu 
        195                 200                 205             


Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly 
    210                 215                 220                 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
225                 230                 235                 240 


Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn 
                245                 250                 255     


Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp 
            260                 265                 270         


Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys 
        275                 280             


<210>  132
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Texas 50 2012 H3N2 amino acid sequence

<400>  132

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met Arg 
65                  70                  75                  80  


Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala Gly 
                85                  90                  95      


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
            100                 105                 110         


Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys Ser 
        115                 120                 125             


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile 
    130                 135                 140                 


Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
145                 150                 155                 160 


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
                165                 170                 175     


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
            180                 185                 190         


Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu 
        195                 200                 205             


Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly 
    210                 215                 220                 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
225                 230                 235                 240 


Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn 
                245                 250                 255     


Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp 
            260                 265                 270         


Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys 
        275                 280             


<210>  133
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Netherlands 219 03 H7N7 amino acid sequence

<400>  133

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Val Ala Ser Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Thr Val Glu Arg Thr Asn Val Pro Arg Tyr Val Lys Gln Glu Ser 
    50                  55                  60                  


Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Arg 
65                  70                  75                  80  


Arg Arg Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly 
                85                  90                  95      


Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala 
            100                 105                 110         


Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile 
        115                 120                 125             


Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln 
    130                 135                 140                 


Gln Phe Glu Leu Ile Asp Asn Glu Phe Thr Glu Val Glu Arg Gln Ile 
145                 150                 155                 160 


Gly Asn Val Ile Asn Trp Thr Arg Asp Ser Met Thr Glu Val Trp Ser 
                165                 170                 175     


Tyr Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp 
            180                 185                 190         


Leu Ala Asp Ser Glu Met Asn Lys Leu Tyr Glu Arg Val Lys Arg Gln 
        195                 200                 205             


Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe 
    210                 215                 220                 


His Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr 
225                 230                 235                 240 


Asp His Ser Lys Tyr Arg Glu Glu Ala Ile Gln Asn Arg Ile Gln Ile 
                245                 250                 255     


Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe 
            260                 265                 270         


Ser Phe Gly Ala Ser Cys 
        275             


