                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  ANTI-CD33 ANTIBODIES AND USES THEREOF

<130>  F053-0129PCT / 20-144-WO-PCT

<150>  US 63/003,219
<151>  2020-03-31

<160>  364   

<170>  PatentIn version 3.5

<210>  1
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33/CD3 bispecific molecule

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Asn Leu Gly Gly Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Trp Ser Asp Gly Tyr Tyr Val Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Thr Val Ser Leu Gly Glu Arg Thr Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Val Leu Asp Ser Ser Thr Asn Lys Asn Ser Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu Ser 
            180                 185                 190         


Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Ser Pro Gln Pro Glu 
    210                 215                 220                 


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Ala His Phe Pro Ile Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    290                 295                 300                 


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
        355                 360                 365             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn 
            420                 425                 430         


Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu His His His His His His 
            500                 505                 510     


<210>  2
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human full-length (FL) CD33 with a mouse Fc domain

<400>  2

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Gly Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
            260                 265                 270         


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
        275                 280                 285             


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
305                 310                 315                 320 


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
                325                 330                 335     


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
    370                 375                 380                 


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
385                 390                 395                 400 


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
                405                 410                 415     


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
            420                 425                 430         


Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
        435                 440                 445             


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
    450                 455                 460                 


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  3
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human delta E2 version of CD33 (CD33 deltaE2) with a mouse Fc 
       domain

<400>  3

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Asp Leu Thr His 
1               5                   10                  15      


Arg Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys 
            20                  25                  30          


Asn Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro 
        35                  40                  45              


Ile Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr 
    50                  55                  60                  


Thr His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly 
65                  70                  75                  80  


Thr Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr 
            100                 105                 110         


Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala 
        115                 120                 125             


Gly Gly Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
    130                 135                 140                 


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
145                 150                 155                 160 


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
                165                 170                 175     


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
            180                 185                 190         


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
        195                 200                 205             


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
                245                 250                 255     


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
            260                 265                 270         


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
        275                 280                 285             


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
    290                 295                 300                 


Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
305                 310                 315                 320 


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
                325                 330                 335     


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  4
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 where the C2-set Ig-like 
       domain from mouse is replaced with the C2-set Ig-like domain from
       human CD33, combined with a Fc region from human lgG1

<400>  4

Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      


Gln Asp Leu Glu Phe Gln Leu Val Ala Pro Glu Ser Val Thr Val Glu 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Val Phe Tyr Pro Ser Ile 
        35                  40                  45              


Lys Leu Thr Leu Gly Pro Val Thr Gly Ser Trp Leu Arg Lys Gly Val 
    50                  55                  60                  


Ser Leu His Glu Asp Ser Pro Val Ala Thr Ser Asp Pro Arg Gln Leu 
65                  70                  75                  80  


Val Gln Lys Ala Thr Gln Gly Arg Phe Gln Leu Leu Gly Asp Pro Gln 
                85                  90                  95      


Lys His Asp Cys Ser Leu Phe Ile Arg Asp Ala Gln Lys Asn Asp Thr 
            100                 105                 110         


Gly Met Tyr Phe Phe Arg Val Val Arg Glu Pro Phe Val Arg Tyr Ser 
        115                 120                 125             


Tyr Lys Lys Ser Gln Leu Ser Leu His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        435                 440                 445             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210>  5
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 (codon optimized) where the 
       C2-set Ig-like domain from mouse is replaced with the C2-set 
       Ig-like domain from human CD33, combined with a Fc region from 
       human lgG1

<400>  5
atgctgtggc ctctgcctct gtttctgctg tgcgctggaa gtctggctca ggatctggaa       60

tttcagctgg tggctcccga atcagtcacc gtggaggagg gcctgtgcgt gcacgtgcct      120

tgtagcgtgt tctacccaag catcaagctg accctgggcc ctgtgacagg ctcctggctg      180

aggaagggcg tgtccctgca cgaggactct ccagtggcca ccagcgatcc taggcagctg      240

gtgcagaagg ccacacaggg cagattccag ctgctgggcg accctcagaa gcacgattgc      300

agcctgttta tccgcgacgc ccagaagaac gataccggca tgtatttctt tcgggtggtg      360

agagagccat tcgtgaggta ctcctataag aagtctcagc tgagcctgca cgtgaccgac      420

ctgacacacc gcccaaagat cctgatccca ggcaccctgg agcctggaca ctctaagaac      480

ctgacatgct ccgtgtcttg ggcatgtgag cagggaaccc cacctatctt ttcctggctg      540

tctgccgcac caacaagcct gggaccaagg accacacaca gctccgtgct gatcatcacc      600

cctagaccac aggatcacgg caccaatctg acatgccagg tgaagttcgc aggagcagga      660

gtgaccacag agaggaccat ccagctgaac gtgacatacg tgcctcagaa tccaaccaca      720

ggcatctttc caggcgacgg ctccggcaag caggagacac gggccggatc cgagcccaag      780

tctagcgata agacccacac atgcccacca tgtccagcac ctgagctgct gggaggacca      840

agcgtgttcc tgtttcctcc aaagcccaag gacacactga tgatctctcg gacccccgag      900

gtgacatgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt taactggtac      960

gtggatggcg tggaggtgca caatgccaag accaagccca gggaggagca gtacaactcc     1020

acctatcgcg tggtgtctgt gctgacagtg ctgcaccagg actggctgaa cggcaaggag     1080

tataagtgca aggtgtccaa taaggccctg ccagccccca tcgagaagac catctctaag     1140

gcaaagggac agcccaggga gcctcaggtg tacacactgc cccctagccg cgacgagctg     1200

accaagaacc aggtgtccct gacatgtctg gtgaagggct tctatccttc tgatatcgcc     1260

gtggagtggg agagcaatgg ccagccagag aacaattaca agaccacacc acccgtgctg     1320

gacagcgatg gctccttctt tctgtatagc aagctgaccg tggataagtc caggtggcag     1380

cagggcaacg tgttcagctg ttccgtgatg cacgaagcac tgcacaacca ctacactcag     1440

aaatcactgt cactgtcccc aggaaagtaa                                      1470


<210>  6
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 where the C2-set Ig-like 
       domain from mouse has been replaced with the C2-set Ig-like 
       domain from human CD33 combined with the transmembrane domain and
       a truncated intracellular domain both derived from human CD33

<400>  6

Met Leu Trp Pro Leu Pro Leu Phe Leu Leu Cys Ala Gly Ser Leu Ala 
1               5                   10                  15      


Gln Asp Leu Glu Phe Gln Leu Val Ala Pro Glu Ser Val Thr Val Glu 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Val Phe Tyr Pro Ser Ile 
        35                  40                  45              


Lys Leu Thr Leu Gly Pro Val Thr Gly Ser Trp Leu Arg Lys Gly Val 
    50                  55                  60                  


Ser Leu His Glu Asp Ser Pro Val Ala Thr Ser Asp Pro Arg Gln Leu 
65                  70                  75                  80  


Val Gln Lys Ala Thr Gln Gly Arg Phe Gln Leu Leu Gly Asp Pro Gln 
                85                  90                  95      


Lys His Asp Cys Ser Leu Phe Ile Arg Asp Ala Gln Lys Asn Asp Thr 
            100                 105                 110         


Gly Met Tyr Phe Phe Arg Val Val Arg Glu Pro Phe Val Arg Tyr Ser 
        115                 120                 125             


Tyr Lys Lys Ser Gln Leu Ser Leu His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr 
        275                 280                 


<210>  7
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Extracellular domain of mouse CD33 where the C2-set Ig-like 
       domain from mouse has been replaced with the C2-set Ig-like 
       domain from human CD33 combined with the transmembrane domain and
       a truncated intracellular domain both derived from human CD33

<400>  7
atgctgtggc ctctgcctct gtttctgctg tgcgctggaa gtctggctca ggatctggaa       60

tttcagctgg tggctcccga atcagtcacc gtggaggagg gcctgtgcgt gcacgtgcct      120

tgtagcgtgt tctacccaag catcaagctg accctgggcc ctgtgacagg ctcctggctg      180

aggaagggcg tgtccctgca cgaggactct ccagtggcca ccagcgatcc taggcagctg      240

gtgcagaagg ccacacaggg cagattccag ctgctgggcg accctcagaa gcacgattgc      300

agcctgttta tccgcgacgc ccagaagaac gataccggca tgtatttctt tcgggtggtg      360

agagagccat tcgtgaggta ctcctataag aagtctcagc tgagcctgca cgtgaccgac      420

ctgacacacc gcccaaagat cctgatccca ggcaccctgg agcctggaca ctctaagaac      480

ctgacatgct ccgtgtcttg ggcatgtgag cagggaaccc cacctatctt ttcctggctg      540

tctgccgcac caacaagcct gggaccaagg accacacaca gctccgtgct gatcatcacc      600

cctagaccac aggatcacgg caccaatctg acatgccagg tgaagttcgc aggagcagga      660

gtgaccacag agaggaccat ccagctgaac gtgacatacg tgcctcagaa tccaaccaca      720

ggcatctttc caggcgacgg ctccggcaag caggagacac gggccggagt ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cctga                                                       855


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H7

<400>  8

Arg Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H7

<400>  9

Tyr Tyr Ser Ser Arg Leu His Ser 
1               5               


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 1H7

<400>  10

Gln Gln Asp Asp Ala Leu Pro Tyr Thr 
1               5                   


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7

<400>  11

Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10              


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  12

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H7

<400>  13

Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 6H9

<400>  14

Arg Ala Ser Gln Asp Ile Asn Ile Tyr Leu Asn 
1               5                   10      


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 6H9, 9G2, and/or 11D11

<400>  15

Tyr Tyr Thr Ser Arg Leu His Ser 
1               5               


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 6H9 and/or 9G2

<400>  16

Gln Gln Gly Asp Thr Leu Pro Trp Thr 
1               5                   


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  17

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser 
1               5                   10              


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  18

Thr Ile Ser Gly Asp Gly Gly Asn Thr Tyr 
1               5                   10  


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 6H9

<400>  19

Ala Arg Gln Gly Thr Gly Thr Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 9G2

<400>  20

Lys Thr Ser Gln Asp Ile Tyr Asn Tyr Leu Asn 
1               5                   10      


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  21

Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   10              


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  22

Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 9G2

<400>  23

Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D5

<400>  24

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Val 
1               5                   10      


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2D5

<400>  25

Tyr Ser Ala Ser Asp Arg Tyr Ser 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 2D5, 3A5v1, and/or 3A5v2

<400>  26

Gln Gln Tyr Asn Ile Tyr Pro Tyr Thr 
1               5                   


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5

<400>  27

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp Met His 
1               5                   10              


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  28

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D5

<400>  29

Thr Ser Asp Tyr Asp Tyr Phe Gly Val 
1               5                   


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 5D12

<400>  30

Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 5D12

<400>  31

Tyr Ala Thr Thr Leu Ala Asp 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 5D12

<400>  32

Leu His His Gly Glu Ser Pro Trp Thr 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 5D12

<400>  33

Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10  


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  34

Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 5D12

<400>  35

Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr 
1               5                   10          


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 variable light chain

<400>  36

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp Ala Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 variable heavy chain

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6H9 variable light chain

<400>  38

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6H9 variable heavy chain

<400>  39

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Asp Gly Gly Asn Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Gly Thr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser 
        115             


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 variable light chain

<400>  40

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Thr Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 variable heavy chain

<400>  41

Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 variable light chain

<400>  42

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Val Trp Tyr His Lys Lys Pro Gly Gln Ser Pro Lys Gly Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asp Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  43
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 variable heavy chain

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asp Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Arg Ile Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Thr Ser Asp Tyr Asp Tyr Phe Gly Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 variable light chain

<400>  44

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly Glu Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 variable heavy chain

<400>  45

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of OKT3

<400>  46

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of OKT3

<400>  47

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of OKT3

<400>  48

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of OKT3

<400>  49

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of OKT3

<400>  50

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of OKT3

<400>  51

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  52
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  52

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 20G6-F3

<400>  53

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 20G6-F3

<400>  54

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 20G6-F3

<400>  55

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 20G6-F3

<400>  56

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 20G6-F3

<400>  57

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4B4-D7

<400>  58

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 4B4-D7

<400>  59

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4B4-D7

<400>  60

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4B4-D7

<400>  61

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4E7-C9

<400>  62

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 4E7-C9

<400>  63

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4E7-C9

<400>  64

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 18F5-H10

<400>  65

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 18F5-H10

<400>  66

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 18F5-H10

<400>  67

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 18F5-H10 antibody

<400>  68

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 18F5-H10 antibody

<400>  69

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  70
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of TGN1412

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of TGN1412

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of anti-CD28

<400>  72

His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
1               5                   10      


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of anti-CD28

<400>  73

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of anti-CD28

<400>  74

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD28

<400>  75

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD28

<400>  76

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys 
1               5                   10                  


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of anti-CD28

<400>  77

Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
1               5                   10      


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of anti-CD28

<400>  78

Ser Tyr Tyr Ile His 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of anti-CD28

<400>  79

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4-1BB binding domain

<400>  80

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 4-1BB binding domain

<400>  81

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 4-1BB binding domain

<400>  82

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4-1BB binding domain

<400>  83

Tyr Tyr Trp Ser 
1               


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4-1BB binding domain

<400>  84

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4-1BB binding domain

<400>  85

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 4-1BB binding domain

<400>  86

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 4-1BB binding domain

<400>  87

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4-1BB binding domain

<400>  88

Gly Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   10  


<210>  89
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4-1BB binding domain

<400>  89

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
1               5                   10                  


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4-1BB binding domain

<400>  90

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of OKT8 antibody

<400>  91

Arg Thr Ser Arg Ser Ile Ser Gln Tyr Leu Ala 
1               5                   10      


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of OKT8 antibody

<400>  92

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of OKT8 antibody

<400>  93

Gln Gln His Asn Glu Asn Pro Leu Thr 
1               5                   


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of OKT8 antibody

<400>  94

Gly Phe Asn Ile Lys Asp 
1               5       


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of OKT8 antibody

<400>  95

Arg Ile Asp Pro Ala Asn Asp Asn Thr 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of OKT8 antibody

<400>  96

Gly Tyr Gly Tyr Tyr Val Phe Asp His 
1               5                   


<210>  97
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL2/3 variable light chain

<400>  97

Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  98
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIR2DL2/3 variable heavy chain

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  99
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(10)
<223>  Residues can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (12)..(20)
<223>  Residues can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (21)..(200)
<223>  Residues can be present or absent

<400>  99

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser 
            180                 185                 190         


Ser Ser Ser Ser Ser Ser Ser Ser 
        195                 200 


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  (GlyGlyGlyGlySer) can be repeated n times, wherin n is an integer
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<400>  100

Gly Gly Gly Gly Ser 
1               5   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  (GlyGlyGlyGlySer) can be repeated n times, wherein n is an 
       integer of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<400>  101

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<220>
<221>  MISC_FEATURE
<222>  (5)..(7)
<223>  (GlyGlySer) can be repeated n times, wherein n is an integer of 
       1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<400>  102

Gly Gly Gly Ser Gly Gly Ser 
1               5           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  (GlyGlyGlySer) can be repeated n times, wherein n is an integer 
       of 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10

<400>  103

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  104
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  105

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  106

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  107
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  107

Gly Gly Gly Gly Ser 
1               5   


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  108

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  109
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  109

Gly Gly Gly Ser 
1               


<210>  110
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  110

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  111

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  112

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GlySer linker

<400>  113

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  114
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 4D protein

<400>  114

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly 
145                 150                 155                 160 


Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser Trp 
                165                 170                 175     


Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala Ala 
            180                 185                 190         


Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile Ile 
        195                 200                 205             


Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu Asn Val 
225                 230                 235                 240 


Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly Asp Gly 
                245                 250                 255     


Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Pro Glu Pro Ser 
            260                 265                 270         


Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu 
        275                 280                 285             


Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp 
    290                 295                 300                 


Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His 
305                 310                 315                 320 


Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala 
                325                 330                 335     


Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp 
            340                 345                 350         


Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met 
        355                 360                 365             


Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser 
    370                 375                 380                 


Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp 
385                 390                 395                 400 


Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp 
                405                 410                 415     


Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala 
            420                 425                 430         


Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val 
        435                 440                 445             


Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser 
    450                 455                 460                 


Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe 
465                 470                 475                 480 


Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe 
                485                 490                 495     


Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn 
            500                 505                 510         


Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu 
        515                 520                 525             


Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val 
    530                 535                 540                 


Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro 
545                 550                 555                 560 


Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro 
                565                 570                 575     


Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser 
            580                 585                 590         


Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser 
        595                 600                 605             


Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Gly Ala Ile 
    610                 615                 620                 


Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu Ile 
625                 630                 635                 640 


Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val 
                645                 650                 655     


Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His 
            660                 665                 670         


Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser 
        675                 680                 685             


Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser 
    690                 695                 700                 


Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr 
705                 710                 715                 720 


Ser Glu Val Arg Thr Gln 
                725     


<210>  115
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 4D nucleotides

<400>  115
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacagacttg acccacaggc ccaaaatcct catccctggc      480

actctagaac ccggccactc caaaaacctg acctgctctg tgtcctgggc ctgtgagcag      540

ggaacacccc cgatcttctc ctggttgtca gctgccccca cctccctggg ccccaggact      600

actcactcct cggtgctcat aatcacccca cggccccagg accacggcac caacctgacc      660

tgtcaggtga agttcgctgg agctggtgtg actacggaga gaaccatcca gctgaacgtc      720

acctatgttc cacagaaccc aacaactggt atctttccag gagatggctc agggaaacaa      780

gagaccagag caggagtggt tcatccggaa ccttccacgg ttcagatcct ccactcaccg      840

gctgtggagg gaagtcaagt cgagtttctt tgcatgtcac tggccaatcc tcttccaaca      900

aattacacgt ggtaccacaa tgggaaagaa atgcagggaa ggacagagga gaaagtccac      960

atcccaaaga tcctcccttg gcacgctggg acttattcct gtgtggcaga aaacattctt     1020

ggtactggac agaggggccc tggagctgag ctggatgtcc agtatcctcc caagaaggtg     1080

accacagtga ttcaaaaccc catgccgatt cgagaaggag acacagtgac cctttcctgt     1140

aactacaatt ccagtaaccc cagtgttacc cggtatgaat ggaaacccca tggcgcctgg     1200

gaggagccat cgcttggggt gctgaagatc caaaacgttg gctgggacaa cacaaccatc     1260

gcctgcgcag cttgtaatag ttggtgctcg tgggcctccc ctgtcgccct gaatgtccag     1320

tatgcccccc gagacgtgag ggtccggaaa atcaagcccc tttccgagat tcactctgga     1380

aactcggtca gcctccaatg tgacttctca agcagccacc ccaaagaagt ccagttcttc     1440

tgggagaaaa atggcaggct tctggggaaa gaaagccagc tgaattttga ctccatctcc     1500

ccagaagatg ctgggagtta cagctgctgg gtgaacaact ccataggaca gacagcgtcc     1560

aaggcctgga cacttgaagt gctgtatgca cccaggaggc tgcgtgtgtc catgagccca     1620

ggggaccaag tgatggaggg gaagagtgca accctgacct gtgagagcga cgccaaccct     1680

cccgtctccc actacacctg gtttgactgg aataaccaaa gcctccccta ccacagccag     1740

aagctgagat tggagccggt gaaggtccag cactcgggtg cctactggtg ccaggggacc     1800

aacagtgtgg gcaagggccg ttcgcctctc agcaccctca ccgtctacta tagcccggag     1860

accggggcca ttggaggagc tggtgttaca gccctgctcg ctctttgtct ctgcctcatc     1920

ttcttcatag tgaagaccca caggaggaaa gcagccagga cagcagtggg caggaatgac     1980

acccacccta ccacagggtc agcctccccg aaacaccaga agaagtccaa gttacatggc     2040

cccactgaaa cctcaagctg ttcaggtgcc gcccctactg tggagatgga tgaggagctg     2100

cattatgctt ccctcaactt tcatgggatg aatccttcca aggacacctc caccgaatac     2160

tcagaggtca ggacccag                                                   2178


<210>  116
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 2D protein

<400>  116

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile Pro Gly 
145                 150                 155                 160 


Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val Ser Trp 
                165                 170                 175     


Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser Ala Ala 
            180                 185                 190         


Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu Ile Ile 
        195                 200                 205             


Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln Val Lys 
    210                 215                 220                 


Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu Asn Val 
225                 230                 235                 240 


Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly Asp Gly 
                245                 250                 255     


Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Pro Arg Asp Val 
            260                 265                 270         


Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser 
        275                 280                 285             


Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln 
    290                 295                 300                 


Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu 
305                 310                 315                 320 


Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp 
                325                 330                 335     


Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu 
            340                 345                 350         


Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp 
        355                 360                 365             


Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala 
    370                 375                 380                 


Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser 
385                 390                 395                 400 


Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln 
                405                 410                 415     


His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly 
            420                 425                 430         


Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Gly 
        435                 440                 445             


Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys 
    450                 455                 460                 


Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr 
465                 470                 475                 480 


Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro 
                485                 490                 495     


Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser 
            500                 505                 510         


Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr 
        515                 520                 525             


Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr 
    530                 535                 540                 


Glu Tyr Ser Glu Val Arg Thr Gln 
545                 550         


<210>  117
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33:CD22 2D protein

<400>  117
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacagacttg acccacaggc ccaaaatcct catccctggc      480

actctagaac ccggccactc caaaaacctg acctgctctg tgtcctgggc ctgtgagcag      540

ggaacacccc cgatcttctc ctggttgtca gctgccccca cctccctggg ccccaggact      600

actcactcct cggtgctcat aatcacccca cggccccagg accacggcac caacctgacc      660

tgtcaggtga agttcgctgg agctggtgtg actacggaga gaaccatcca gctgaacgtc      720

acctatgttc cacagaaccc aacaactggt atctttccag gagatggctc agggaaacaa      780

gagaccagag caggagtggt tcatccccga gacgtgaggg tccggaaaat caagcccctt      840

tccgagattc actctggaaa ctcggtcagc ctccaatgtg acttctcaag cagccacccc      900

aaagaagtcc agttcttctg ggagaaaaat ggcaggcttc tggggaaaga aagccagctg      960

aattttgact ccatctcccc agaagatgct gggagttaca gctgctgggt gaacaactcc     1020

ataggacaga cagcgtccaa ggcctggaca cttgaagtgc tgtatgcacc caggaggctg     1080

cgtgtgtcca tgagcccagg ggaccaagtg atggagggga agagtgcaac cctgacctgt     1140

gagagcgacg ccaaccctcc cgtctcccac tacacctggt ttgactggaa taaccaaagc     1200

ctcccctacc acagccagaa gctgagattg gagccggtga aggtccagca ctcgggtgcc     1260

tactggtgcc aggggaccaa cagtgtgggc aagggccgtt cgcctctcag caccctcacc     1320

gtctactata gcccggagac cggggccatt ggaggagctg gtgttacagc cctgctcgct     1380

ctttgtctct gcctcatctt cttcatagtg aagacccaca ggaggaaagc agccaggaca     1440

gcagtgggca ggaatgacac ccaccctacc acagggtcag cctccccgaa acaccagaag     1500

aagtccaagt tacatggccc cactgaaacc tcaagctgtt caggtgccgc ccctactgtg     1560

gagatggatg aggagctgca ttatgcttcc ctcaactttc atgggatgaa tccttccaag     1620

gacacctcca ccgaatactc agaggtcagg acccag                               1656


<210>  118
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 V-set construct (exon 3 and 4 deleted) protein

<400>  118

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met His His His His His His Gly Gly Gly Asp Pro Asn Phe Trp Leu 
            20                  25                  30          


Gln Val Gln Glu Ser Val Thr Val Gln Glu Gly Leu Cys Val Leu Val 
        35                  40                  45              


Pro Cys Thr Phe Phe His Pro Ile Pro Tyr Tyr Asp Lys Asn Ser Pro 
    50                  55                  60                  


Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg Asp Ser 
65                  70                  75                  80  


Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu Thr Gln 
                85                  90                  95      


Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys Ser Leu 
            100                 105                 110         


Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe Phe Arg 
        115                 120                 125             


Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln Leu Ser 
    130                 135                 140                 


Val His Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro 
145                 150                 155                 160 


Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Gly 
                165                 170                 175     


Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys 
            180                 185                 190         


Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr 
        195                 200                 205             


Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro 
    210                 215                 220                 


Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser 
225                 230                 235                 240 


Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr 
                245                 250                 255     


Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr 
            260                 265                 270         


Glu Tyr Ser Glu Val Arg Thr Gln 
        275                 280 


<210>  119
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 V-set construct (exon 3 and 4 deleted) nucleotides

<400>  119
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat gcatcatcac       60

caccatcacg gcggcggcga tccaaatttc tggctgcaag tgcaggagtc agtgacggta      120

caggagggtt tgtgcgtcct cgtgccctgc actttcttcc atcccatacc ctactacgac      180

aagaactccc cagttcatgg ttactggttc cgggaaggag ccattatatc cagggactct      240

ccagtggcca caaacaagct agatcaagaa gtacaggagg agactcaggg cagattccgc      300

ctccttgggg atcccagtag gaacaactgc tccctgagca tcgtagacgc caggaggagg      360

gataatggtt catacttctt tcggatggag agaggaagta ccaaatacag ttacaaatct      420

ccccagctct ctgtgcatgt gacatatgtt ccacagaacc caacaactgg tatctttcca      480

ggagatggct cagggaaaca agagaccaga gcaggagtgg ttcatggggc cattggagga      540

gctggtgtta cagccctgct cgctctttgt ctctgcctca tcttcttcat agtgaagacc      600

cacaggagga aagcagccag gacagcagtg ggcaggaatg acacccaccc taccacaggg      660

tcagcctccc cgaaacacca gaagaagtcc aagttacatg gccccactga aacctcaagc      720

tgttcaggtg ccgcccctac tgtggagatg gatgaggagc tgcattatgc ttccctcaac      780

tttcatggga tgaatccttc caaggacacc tccaccgaat actcagaggt caggacccag      840


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 signal peptide

<400>  120

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met 
    


<210>  121
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 signal peptide coding sequence

<400>  121
atgcctctgc tgctactgct acctctgctg tgggctggag ccctggctat g                51


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  122

His His His His His His 
1               5       


<210>  123
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His tag coding sequence

<400>  123
catcatcacc accatcac                                                     18


<210>  124
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain

<400>  124

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  125
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain coding sequence

<400>  125
gatccaaatt tctggctgca agtgcaggag tcagtgacgg tacaggaggg tttgtgcgtc       60

ctcgtgccct gcactttctt ccatcccata ccctactacg acaagaactc cccagttcat      120

ggttactggt tccgggaagg agccattata tccagggact ctccagtggc cacaaacaag      180

ctagatcaag aagtacagga ggagactcag ggcagattcc gcctccttgg ggatcccagt      240

aggaacaact gctccctgag catcgtagac gccaggagga gggataatgg ttcatacttc      300

tttcggatgg agagaggaag taccaaatac agttacaaat ctccccagct ctctgtgcat      360

gtgacagact tgacccacag gcccaaaatc ctcatccctg gcactctaga acccggccac      420

tccaaaaacc tgacctgctc tgtgtcctgg gcctgtgagc agggaacacc cccgatcttc      480

tcctggttgt cagctgcccc cacctccctg ggccccagga ctactcactc ctcggtgctc      540

ataatcaccc cacggcccca ggaccacggc accaacctga cctgtcaggt gaagttcgct      600

ggagctggtg tgactacgga gagaaccatc cagctgaacg tcacctatgt tccacagaac      660

ccaacaactg gtatctttcc aggagatggc tcagggaaac aagagaccag agcaggagtg      720

gttcat                                                                 726


<210>  126
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain lacking CD33 amino acids 140-232

<400>  126

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Tyr Val Pro Gln Asn Pro 
        115                 120                 125             


Thr Thr Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg 
    130                 135                 140                 


Ala Gly Val Val His 
145                 


<210>  127
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 extracellular domain lacking CD33 amino acids 140-232 coding
       sequence

<400>  127
gatccaaatt tctggctgca agtgcaggag tcagtgacgg tacaggaggg tttgtgcgtc       60

ctcgtgccct gcactttctt ccatcccata ccctactacg acaagaactc cccagttcat      120

ggttactggt tccgggaagg agccattata tccagggact ctccagtggc cacaaacaag      180

ctagatcaag aagtacagga ggagactcag ggcagattcc gcctccttgg ggatcccagt      240

aggaacaact gctccctgag catcgtagac gccaggagga gggataatgg ttcatacttc      300

tttcggatgg agagaggaag taccaaatac agttacaaat ctccccagct ctctgtgcat      360

gtgacatatg ttccacagaa cccaacaact ggtatctttc caggagatgg ctcagggaaa      420

caagagacca gagcaggagt ggttcat                                          447


<210>  128
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 transmembrane domain

<400>  128

Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Cys Leu Ile Phe Phe Ile Val 
            20              


<210>  129
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 transmembrane domain coding sequence

<400>  129
ggggccattg gaggagctgg tgttacagcc ctgctcgctc tttgtctctg cctcatcttc       60

ttcatagtg                                                               69


<210>  130
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 intracellular domain

<400>  130

Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp 
1               5                   10                  15      


Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser 
            20                  25                  30          


Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro 
        35                  40                  45              


Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His 
    50                  55                  60                  


Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg 
65                  70                  75                  80  


Thr Gln 
        


<210>  131
<211>  246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 intracellular domain coding sequence

<400>  131
aagacccaca ggaggaaagc agccaggaca gcagtgggca ggaatgacac ccaccctacc       60

acagggtcag cctccccgaa acaccagaag aagtccaagt tacatggccc cactgaaacc      120

tcaagctgtt caggtgccgc ccctactgtg gagatggatg aggagctgca ttatgcttcc      180

ctcaactttc atgggatgaa tccttccaag gacacctcca ccgaatactc agaggtcagg      240

acccag                                                                 246


<210>  132
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 3, Ig-like C2-type 4, Ig-like C2-type 
       5, Ig-like C2-type 6

<400>  132

Pro Glu Pro Ser Thr Val Gln Ile Leu His Ser Pro Ala Val Glu Gly 
1               5                   10                  15      


Ser Gln Val Glu Phe Leu Cys Met Ser Leu Ala Asn Pro Leu Pro Thr 
            20                  25                  30          


Asn Tyr Thr Trp Tyr His Asn Gly Lys Glu Met Gln Gly Arg Thr Glu 
        35                  40                  45              


Glu Lys Val His Ile Pro Lys Ile Leu Pro Trp His Ala Gly Thr Tyr 
    50                  55                  60                  


Ser Cys Val Ala Glu Asn Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Asp Val Gln Tyr Pro Pro Lys Lys Val Thr Thr Val Ile 
                85                  90                  95      


Gln Asn Pro Met Pro Ile Arg Glu Gly Asp Thr Val Thr Leu Ser Cys 
            100                 105                 110         


Asn Tyr Asn Ser Ser Asn Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro 
        115                 120                 125             


His Gly Ala Trp Glu Glu Pro Ser Leu Gly Val Leu Lys Ile Gln Asn 
    130                 135                 140                 


Val Gly Trp Asp Asn Thr Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp 
145                 150                 155                 160 


Cys Ser Trp Ala Ser Pro Val Ala Leu Asn Val Gln Tyr Ala Pro Arg 
                165                 170                 175     


Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His Ser Gly 
            180                 185                 190         


Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro Lys Glu 
        195                 200                 205             


Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser 
    210                 215                 220                 


Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser 
225                 230                 235                 240 


Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr 
                245                 250                 255     


Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met Ser Pro 
            260                 265                 270         


Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser 
        275                 280                 285             


Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp Asn Asn 
    290                 295                 300                 


Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro Val Lys 
305                 310                 315                 320 


Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly 
                325                 330                 335     


Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu 
            340                 345                 350         


Thr 
    


<210>  133
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 3, Ig-like C2-type 4, Ig-like C2-type 
       5, Ig-like C2-type 6 coding sequence

<400>  133
ccggaacctt ccacggttca gatcctccac tcaccggctg tggagggaag tcaagtcgag       60

tttctttgca tgtcactggc caatcctctt ccaacaaatt acacgtggta ccacaatggg      120

aaagaaatgc agggaaggac agaggagaaa gtccacatcc caaagatcct cccttggcac      180

gctgggactt attcctgtgt ggcagaaaac attcttggta ctggacagag gggccctgga      240

gctgagctgg atgtccagta tcctcccaag aaggtgacca cagtgattca aaaccccatg      300

ccgattcgag aaggagacac agtgaccctt tcctgtaact acaattccag taaccccagt      360

gttacccggt atgaatggaa accccatggc gcctgggagg agccatcgct tggggtgctg      420

aagatccaaa acgttggctg ggacaacaca accatcgcct gcgcagcttg taatagttgg      480

tgctcgtggg cctcccctgt cgccctgaat gtccagtatg ccccccgaga cgtgagggtc      540

cggaaaatca agcccctttc cgagattcac tctggaaact cggtcagcct ccaatgtgac      600

ttctcaagca gccaccccaa agaagtccag ttcttctggg agaaaaatgg caggcttctg      660

gggaaagaaa gccagctgaa ttttgactcc atctccccag aagatgctgg gagttacagc      720

tgctgggtga acaactccat aggacagaca gcgtccaagg cctggacact tgaagtgctg      780

tatgcaccca ggaggctgcg tgtgtccatg agcccagggg accaagtgat ggaggggaag      840

agtgcaaccc tgacctgtga gagcgacgcc aaccctcccg tctcccacta cacctggttt      900

gactggaata accaaagcct cccctaccac agccagaagc tgagattgga gccggtgaag      960

gtccagcact cgggtgccta ctggtgccag gggaccaaca gtgtgggcaa gggccgttcg     1020

cctctcagca ccctcaccgt ctactatagc ccggagacc                            1059


<210>  134
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 5, Ig-like C2-type 6

<400>  134

Pro Arg Asp Val Arg Val Arg Lys Ile Lys Pro Leu Ser Glu Ile His 
1               5                   10                  15      


Ser Gly Asn Ser Val Ser Leu Gln Cys Asp Phe Ser Ser Ser His Pro 
            20                  25                  30          


Lys Glu Val Gln Phe Phe Trp Glu Lys Asn Gly Arg Leu Leu Gly Lys 
        35                  40                  45              


Glu Ser Gln Leu Asn Phe Asp Ser Ile Ser Pro Glu Asp Ala Gly Ser 
    50                  55                  60                  


Tyr Ser Cys Trp Val Asn Asn Ser Ile Gly Gln Thr Ala Ser Lys Ala 
65                  70                  75                  80  


Trp Thr Leu Glu Val Leu Tyr Ala Pro Arg Arg Leu Arg Val Ser Met 
                85                  90                  95      


Ser Pro Gly Asp Gln Val Met Glu Gly Lys Ser Ala Thr Leu Thr Cys 
            100                 105                 110         


Glu Ser Asp Ala Asn Pro Pro Val Ser His Tyr Thr Trp Phe Asp Trp 
        115                 120                 125             


Asn Asn Gln Ser Leu Pro Tyr His Ser Gln Lys Leu Arg Leu Glu Pro 
    130                 135                 140                 


Val Lys Val Gln His Ser Gly Ala Tyr Trp Cys Gln Gly Thr Asn Ser 
145                 150                 155                 160 


Val Gly Lys Gly Arg Ser Pro Leu Ser Thr Leu Thr Val Tyr Tyr Ser 
                165                 170                 175     


Pro Glu Thr 
            


<210>  135
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of CD22 extracellular domain that contains CD22 domains 
       defined as Ig-like C2-type 5, Ig-like C2-type 6 coding sequence

<400>  135
ccccgagacg tgagggtccg gaaaatcaag cccctttccg agattcactc tggaaactcg       60

gtcagcctcc aatgtgactt ctcaagcagc caccccaaag aagtccagtt cttctgggag      120

aaaaatggca ggcttctggg gaaagaaagc cagctgaatt ttgactccat ctccccagaa      180

gatgctggga gttacagctg ctgggtgaac aactccatag gacagacagc gtccaaggcc      240

tggacacttg aagtgctgta tgcacccagg aggctgcgtg tgtccatgag cccaggggac      300

caagtgatgg aggggaagag tgcaaccctg acctgtgaga gcgacgccaa ccctcccgtc      360

tcccactaca cctggtttga ctggaataac caaagcctcc cctaccacag ccagaagctg      420

agattggagc cggtgaaggt ccagcactcg ggtgcctact ggtgccaggg gaccaacagt      480

gtgggcaagg gccgttcgcc tctcagcacc ctcaccgtct actatagccc ggagacc         537


<210>  136
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7/CD3 bispecific molecule

<400>  136

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
305                 310                 315                 320 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
            340                 345                 350         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
        355                 360                 365             


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                405                 410                 415     


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
            420                 425                 430         


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
465                 470                 475                 480 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                485                 490                 495     


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            500                 505                 510         


Leu His His His His His His 
        515                 


<210>  137
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgK signal peptide

<400>  137

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  138
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 LcFv

<400>  138

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  139
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 HcFv

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  140
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variable light chain

<400>  140

Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Ser Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  141
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 variable heavychain

<400>  141

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  142
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 variable heavy chain

<400>  142

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  143
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D5 variable light chain

<400>  143

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Phe Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile His Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  144
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D5 variant 1 variable heavy chain

<400>  144

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Leu Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Gly Thr Gly Thr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  145
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D5 variant 2 variable heavy chain

<400>  145

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Asn Ile Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Leu Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Gly Thr Gly Thr Gly Asp His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  146
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 antibody variable light chain codon optimized nucleotides

<400>  146
gatgttgtaa tgacgcagtc tcaaaagttt atgtcaacgt ctgttggtga tcgcgttagc       60

attacctgca aagcatctca aagtgtagga tctgatgtgg catggtacca gcaacggcct      120

ggacgctgtc ctaaagcgct gatttatctt gcttctaacc ggcatacggg ggtcccagac      180

aggtttactg ggtctggatc tggaacggac tttacactga ccatatcaaa cgttcagtca      240

gaggacctgg ccgagtattt ctgtcaacaa tataacatat acccctatac cttcggtgga      300

ggaactaaat tggagataaa g                                                321


<210>  147
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variable heavy chain variant 1 codon optimized nucleotides

<400>  147
caggtgcaac tccagcagtc cggcgccgag ctggtcaggc caggtgcatc cgtaactctg       60

tcatgtaagg cgtccggata caccttcacg gactacgaaa tgcattggat aaaacaaact      120

ccagttcatg ggttggagtg gattggctcc atagacccgg aaacgggagt aacggcgtat      180

aaccagaaat tcacggggaa agcgatagta acggcagaca agtctagtag cactgcctac      240

atggaactta gaagtctcac aagtgaagac agcgcggtat attattgcac ctccgattat      300

ggatactttg acgtttgggg tacgggcacg acagtgactg ttagttct                   348


<210>  148
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A5 variable heavy chain variant 2 codon optimized nucleotides

<400>  148
caggtgcaac tccagcagtc cggcgccgag ctggtcaggc caggtgcatc cgtaactctg       60

tcatgtaagg cgtccggata caccttcacg gactacgaaa tgcattggat aaaacaaact      120

ccagttcatg ggttggagtg gattggctcc atagacccgg aaacgggagt aacggcgtat      180

aaccagaaat tcacggggaa agcgatagta acggcagaca agtctagtag cactgcctac      240

atggaactta gaagtctcac aagtgaagac agcgcggtat attattgcac ctccgattat      300

ggatacttta acgtttgggg tacgggcacg acagtgactg ttagttct                   348


<210>  149
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variable light chain variant codon optimized nucleotides

<400>  149
gatattcaga tgacccaaac gacttcatca ttgagtgcct cccttgggga tcgagttacg       60

atttcatgca gggccagcca agatattttc aattacctga attggtatca gcagaagcct      120

gacggtacag tcaaactttt gatctattac gccagtagat tgcacagcgg cgtaccaagt      180

cgatttagcg ggagcggaag tggcacagac tactccctta caattcataa cctggaacag      240

gaggacatag ctacctattt ctgtcaacaa ggggacacgc tgccttacac gtttggcgga      300

ggcactaaac ttgaaataaa g                                                321


<210>  150
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variable heavy chain variant 1 codon optimized nucleotides

<400>  150
caggttcaac ttaaagagag cggccccggc ctggtcgcac cctctcagtc tctctccatc       60

acatgcactg tgagcgggtt ttcactcaca agctacaaca ttaactggat aagacaacca      120

ccgggaaaag gattggaatg gttgggtgtg atatggaccg gtggagacac gaactataac      180

tccgccttta tgagtaggct tagtatatcc aaagacaatt caaagagtca actgttcctg      240

aagatgaata gcctccagac ggacgacacg gccatctact actgcgttcg ggacgggact      300

ggcactgggg actattttga ctactggggg caaggtacga ctctgacggt gtcaagc         357


<210>  151
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7D5 variable heavy chain variant 2 codon optimized nucleotides

<400>  151
caggttcaac ttaaagagag cggccccggc ctggtcgcac cctctcagtc tctctccatc       60

acatgcactg tgagcgggtt ttcactcaca agctacaaca ttaactggat aagacaacca      120

ccgggaaaag gattggaatg gttgggtgtg atatggaccg gtggagacac gaactataac      180

tccgccttta tgagtaggct tagtatatcc aaagacaatt caaagagtca actgttcctg      240

aagatgaata gcctccagac ggacgacacg gccatctact actgcgttcg ggacgggact      300

ggcactgggg accattttga ctactggggg caaggtacga ctctgacggt gtcaagc         357


<210>  152
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 scFv VH-VL orientation

<400>  152

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr 
65                  70                  75                  80  


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
                165                 170                 175     


Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
    210                 215                 220                 


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
225                 230                 235                 240 


Gln Gln Asp Asp Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys 
            


<210>  153
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 scFv VL-VH orientation

<400>  153

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  154
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 scFv VH-VL orientation

<400>  154

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Ser Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Val Pro Glu Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Leu Asp Ser Leu Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
                165                 170                 175     


Cys Lys Thr Ser Gln Asp Ile Tyr Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
        195                 200                 205             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys 
            260     


<210>  155
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 scFv VH-VL orientation

<400>  155

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Lys Thr Ser Gln Asp 
        35                  40                  45              


Ile Tyr Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser Ser Met 
145                 150                 155                 160 


Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met 
                165                 170                 175     


Ser Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val Ala Ser 
            180                 185                 190         


Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu Lys Ser 
        195                 200                 205             


Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr Leu Gln 
    210                 215                 220                 


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                245                 250                 255     


Leu Thr Val Ser Ser 
            260     


<210>  156
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 scFv VH-VL orientation

<400>  156

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr 
65                  70                  75                  80  


Asn Gly Gln Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly Glu Arg Val Thr 
                165                 170                 175     


Ile Asn Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile Tyr Tyr Ala Thr 
        195                 200                 205             


Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Asp Asp Thr Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Leu His His Gly Glu Ser Pro Trp Thr Phe Gly Glu 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys 
            260             


<210>  157
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 scFv VL-VH orientation

<400>  157

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser 
            260             


<210>  158
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 scFv VH-VL orientation

<400>  158

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ser Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Gln Lys 
145                 150                 155                 160 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Ser Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Arg Cys Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
225                 230                 235                 240 


Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys 
        


<210>  159
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 scFv VL-VH orientation

<400>  159

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met 
                165                 170                 175     


His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ser 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr Gly 
        195                 200                 205             


Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Ser 
225                 230                 235                 240 


Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  160
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 scFv VH-VL orientation

<400>  160

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ser Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Gln Lys 
145                 150                 155                 160 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Ser Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Arg Cys Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
225                 230                 235                 240 


Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys 
        


<210>  161
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 scFv VL-VH orientation

<400>  161

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met 
                165                 170                 175     


His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ser 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr Gly 
        195                 200                 205             


Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Ser 
225                 230                 235                 240 


Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  162
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 scFv VH-VL /CD3 bispecific antibody

<400>  162

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr 
65                  70                  75                  80  


Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg 
                165                 170                 175     


Ala Ser Gln Asp Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
    210                 215                 220                 


Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
225                 230                 235                 240 


Gln Gln Asp Asp Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
305                 310                 315                 320 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
            340                 345                 350         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
        355                 360                 365             


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                405                 410                 415     


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
            420                 425                 430         


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
465                 470                 475                 480 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                485                 490                 495     


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            500                 505                 510         


Leu His His His His His His 
        515                 


<210>  163
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H7 scFv VL-VH /CD3 bispecific antibody

<400>  163

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Asp Asp 
            100                 105                 110         


Ala Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Glu Asp Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
305                 310                 315                 320 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
            340                 345                 350         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
        355                 360                 365             


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
    370                 375                 380                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
                405                 410                 415     


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
            420                 425                 430         


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
        435                 440                 445             


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
    450                 455                 460                 


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
465                 470                 475                 480 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
                485                 490                 495     


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            500                 505                 510         


Leu His His His His His His 
        515                 


<210>  164
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 scFv VH-VL /CD3 bispecific antibody

<400>  164

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Lys Leu Val Glu Ser Glu Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Ser Ser Met Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Val Pro Glu Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Leu Asp Ser Leu Lys Ser Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
                165                 170                 175     


Cys Lys Thr Ser Gln Asp Ile Tyr Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu 
        195                 200                 205             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Phe Cys Gln Gln Gly Asp Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
305                 310                 315                 320 


Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe 
                325                 330                 335     


Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
        355                 360                 365             


Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                405                 410                 415     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
            420                 425                 430         


Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro 
    450                 455                 460                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
465                 470                 475                 480 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                485                 490                 495     


Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Thr Val Leu His His His His His His 
        515                 520     


<210>  165
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G2 scFv VL-VH /CD3 bispecific antibody

<400>  165

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Lys Thr Ser Gln Asp 
        35                  40                  45              


Ile Tyr Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asp 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Lys Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Ser Ser Met 
145                 150                 155                 160 


Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met 
                165                 170                 175     


Ser Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val Ala Ser 
            180                 185                 190         


Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu Lys Ser 
        195                 200                 205             


Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Asn Ile Leu Tyr Leu Gln 
    210                 215                 220                 


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                245                 250                 255     


Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
305                 310                 315                 320 


Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe 
                325                 330                 335     


Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly 
        355                 360                 365             


Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu 
                405                 410                 415     


Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
            420                 425                 430         


Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro 
        435                 440                 445             


Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro 
    450                 455                 460                 


Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
465                 470                 475                 480 


Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
                485                 490                 495     


Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Thr Val Leu His His His His His His 
        515                 520     


<210>  166
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 scFv VH-VL /CD3 bispecific antibody

<400>  166

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr 
65                  70                  75                  80  


Asn Gly Gln Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Ile Tyr Ala Ser Leu Gly Glu Arg Val Thr 
                165                 170                 175     


Ile Asn Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile Tyr Tyr Ala Thr 
        195                 200                 205             


Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Asp Asp Thr Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Leu His His Gly Glu Ser Pro Trp Thr Phe Gly Glu 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu His His His His His His 
        515                 520             


<210>  167
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D12 scFv VL-VH/CD3 bispecific antibody

<400>  167

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Ile Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Thr Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu His His Gly 
            100                 105                 110         


Glu Ser Pro Trp Thr Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Ile Ser Cys Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met 
                165                 170                 175     


Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile Gly Gln 
            180                 185                 190         


Ile Tyr Pro Gly Asn Phe Asn Thr Asp Tyr Asn Gly Gln Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
225                 230                 235                 240 


Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
305                 310                 315                 320 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
            340                 345                 350         


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
        355                 360                 365             


His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
                405                 410                 415     


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
            420                 425                 430         


Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
        435                 440                 445             


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 
    450                 455                 460                 


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
465                 470                 475                 480 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
                485                 490                 495     


Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
            500                 505                 510         


Lys Leu Thr Val Leu His His His His His His 
        515                 520             


<210>  168
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 scFv VH-VL /CD3 bispecific antibody

<400>  168

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ser Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Gln Lys 
145                 150                 155                 160 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Ser Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Arg Cys Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
225                 230                 235                 240 


Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
305                 310                 315                 320 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
            340                 345                 350         


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
        355                 360                 365             


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
                405                 410                 415     


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
            420                 425                 430         


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
        435                 440                 445             


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
465                 470                 475                 480 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
                485                 490                 495     


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505                 510         


His His His His His His 
        515             


<210>  169
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 1 scFv VL-VH /CD3 bispecific antibody

<400>  169

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met 
                165                 170                 175     


His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ser 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr Gly 
        195                 200                 205             


Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Ser 
225                 230                 235                 240 


Asp Tyr Gly Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
305                 310                 315                 320 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
            340                 345                 350         


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
        355                 360                 365             


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
                405                 410                 415     


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
            420                 425                 430         


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
        435                 440                 445             


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
465                 470                 475                 480 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
                485                 490                 495     


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505                 510         


His His His His His His 
        515             


<210>  170
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 scFv VH-VL /CD3 bispecific antibody

<400>  170

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Glu Met His Trp Ile Lys Gln Thr Pro Val His Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Thr Gly Lys Ala Ile Val Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Thr Ser Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Gln Lys 
145                 150                 155                 160 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
                165                 170                 175     


Ser Gln Ser Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Arg Cys Pro Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
225                 230                 235                 240 


Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                245                 250                 255     


Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
305                 310                 315                 320 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
            340                 345                 350         


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
        355                 360                 365             


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
                405                 410                 415     


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
            420                 425                 430         


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
        435                 440                 445             


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
465                 470                 475                 480 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
                485                 490                 495     


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505                 510         


His His His His His His 
        515             


<210>  171
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A5 variant 2 scFv VL-VH /CD3 bispecific antibody

<400>  171

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Asp Val Ala Trp Tyr Gln Gln Arg Pro Gly Arg Cys Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val 
145                 150                 155                 160 


Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met 
                165                 170                 175     


His Trp Ile Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile Gly Ser 
            180                 185                 190         


Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr Gly 
        195                 200                 205             


Lys Ala Ile Val Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
    210                 215                 220                 


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Ser 
225                 230                 235                 240 


Asp Tyr Gly Tyr Phe Asn Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn 
305                 310                 315                 320 


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys 
            340                 345                 350         


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly 
        355                 360                 365             


Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
                405                 410                 415     


Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val 
            420                 425                 430         


Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
        435                 440                 445             


Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro 
    450                 455                 460                 


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
465                 470                 475                 480 


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp 
                485                 490                 495     


Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            500                 505                 510         


His His His His His His 
        515             


<210>  172
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  172
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggctat ggatccaaat       60

ttctggctgc aagtgcagga gtcagtgacg gtacaggagg gtttgtgcgt cctcgtgccc      120

tgcactttct tccatcccat accctactac gacaagaact ccccagttca tggttactgg      180

ttccgggaag gagccattat atccagggac tctccagtgg ccacaaacaa gctagatcaa      240

gaagtacagg aggagactca gggcagattc cgcctccttg gggatcccag taggaacaac      300

tgctccctga gcatcgtaga cgccaggagg agggataatg gttcatactt ctttcggatg      360

gagagaggaa gtaccaaata cagttacaaa tctccccagc tctctgtgca tgtgacagac      420

ttgacccaca ggcccaaaat cctcatccct ggcactctag aacccggcca ctccaaaaac      480

ctgacctgct ctgtgtcctg ggcctgtgag cagggaacac ccccgatctt ctcctggttg      540

tcagctgccc ccacctccct gggccccagg actactcact cctcggtgct cataatcacc      600

ccacggcccc aggaccacgg caccaacctg acctgtcagg tgaagttcgc tggagctggt      660

gtgactacgg agagaaccat ccagctcaac gtcacctatg ttccacagaa cccaacaact      720

ggtatctttc caggagatgg ctcagggaaa caagagacca gagcaggagt ggttcatggg      780

gccattggag gagctggtgt tacagccctg ctcgctcttt gtctctgcct catcttcttc      840

atagtgaaga cccacaggag gaaagcagcc aggacagcag tgggcaggaa tgacacccac      900

cctaccacag ggtcagcctc cccgaaacac cagaagaagt ccaagttaca tggccccact      960

gaaacctcaa gctgttcagg tgccgcccct actgtggaga tggatgagga gctgcattat     1020

gcttccctca actttcatgg gatgaatcct tccaaggaca cctccaccga atactcagag     1080

gtcaggaccc ag                                                         1092


<210>  173
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 8F5

<400>  174

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 8F5

<400>  175

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  176
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 8F5

<400>  176

Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5

<400>  177

Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Tyr 
1               5                   10      


<210>  178
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  178

Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr Pro Asp Thr Val Glu 
1               5                   10                  15      


Gly 
    


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 8F5

<400>  179

Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
1               5                   10  


<210>  180
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 12B12

<400>  180

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 12B12 and/or 11D5

<400>  181

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 12B12 and/or 11D5

<400>  182

Ala Gln Asn Leu Glu Leu Pro Pro Thr 
1               5                   


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  183

Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10  


<210>  184
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  184

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
1               5                   10              


<210>  185
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 12B12

<400>  185

Tyr Asp Gly Tyr His Phe Ile 
1               5           


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D11

<400>  186

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 11D11, 6H9, and/or 9G2

<400>  187

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 11D11

<400>  188

Gln Gln Gly Ser Thr Leu Pro Pro Thr 
1               5                   


<210>  189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D11

<400>  189

Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Glu 
1               5                   10      


<210>  190
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  190

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr 
1               5                   10              


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D11

<400>  191

Asp Thr Gly Pro Met Asp Tyr 
1               5           


<210>  192
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7E7

<400>  192

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7E7

<400>  193

Val Ser Lys Leu Asp Ser Gly 
1               5           


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 7E7

<400>  194

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  195
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  195

Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly Ile Gly 
1               5                   10          


<210>  196
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  196

His Ile Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro Asp Leu Lys Ser 
1               5                   10                  15      


<210>  197
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7E7

<400>  197

Asp Gly Gly Tyr Ser Leu Phe Ala Tyr 
1               5                   


<210>  198
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D5

<400>  198

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  199

Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  200
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  200

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
1               5                   10              


<210>  201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D5

<400>  201

Tyr Asp Gly Tyr His Phe Asp Tyr 
1               5               


<210>  202
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 13E11

<400>  202

Lys Ala Ser His Gly Val Glu Tyr Ala Gly Ala His Tyr Met Asn 
1               5                   10                  15  


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 13E11

<400>  203

Ala Ala Ser Asn Leu Gly Ser 
1               5           


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 13E11

<400>  204

Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  205

Gly Tyr Thr Phe Thr Asp Tyr Thr Leu His 
1               5                   10  


<210>  206
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  206

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu 
1               5                   10              


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 13E11

<400>  207

His Lys Phe Gly Phe Asp Tyr 
1               5           


<210>  208
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 5D12

<400>  208

Tyr Tyr Ala Thr Thr Leu Ala Asp 
1               5               


<210>  209
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 5D12

<400>  209

Arg Ala Ser Gly Tyr Ala Phe Ser Asn Tyr Trp Met Asn 
1               5                   10              


<210>  210
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  210

Gln Ile Tyr Pro Gly Asn Phe Asn Thr Asp 
1               5                   10  


<210>  211
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 5D12

<400>  211

Ala Arg Phe Phe Asp Phe Gly Ala Tyr Phe Thr Leu Asp Tyr 
1               5                   10                  


<210>  212
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 3A5v1 and/or 3A5v2

<400>  212

Lys Ala Ser Gln Ser Val Gly Ser Asp Val Ala 
1               5                   10      


<210>  213
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 3A5v1 and/or 3A5v2

<400>  213

Tyr Leu Ala Ser Asn Arg His Thr 
1               5               


<210>  214
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 3A5v1 and/or 3A5v2

<400>  214

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met His 
1               5                   10              


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  215

Ser Ile Asp Pro Glu Thr Gly Val Thr Ala 
1               5                   10  


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v1

<400>  216

Thr Ser Asp Tyr Gly Tyr Phe Asp Val 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v2

<400>  217

Thr Ser Asp Tyr Gly Tyr Phe Asn Val 
1               5                   


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7D5v1 and/or 7D5v2

<400>  218

Arg Ala Ser Gln Asp Ile Phe Asn Tyr Leu Asn 
1               5                   10      


<210>  219
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7D5v1 and/or 7D5v2

<400>  219

Tyr Tyr Ala Ser Arg Leu His Ser 
1               5               


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 7D5v1 and/or 7D5v2

<400>  220

Gln Gln Gly Asp Thr Leu Pro Tyr Thr 
1               5                   


<210>  221
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  221

Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Asn Ile Asn 
1               5                   10              


<210>  222
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  222

Val Ile Trp Thr Gly Gly Asp Thr Asn 
1               5                   


<210>  223
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v1

<400>  223

Val Arg Asp Gly Thr Gly Thr Gly Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  224
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v2

<400>  224

Val Arg Asp Gly Thr Gly Thr Gly Asp His Phe Asp Tyr 
1               5                   10              


<210>  225
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 8F5

<400>  225

Tyr Trp Ala Ser Thr Arg Glu Ser 
1               5               


<210>  226
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5

<400>  226

Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Tyr 
1               5                   10              


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  227

Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr 
1               5                   10  


<210>  228
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 8F5

<400>  228

Thr Lys Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  229
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 12B12 and/or 11D5

<400>  229

Tyr Gln Met Ser Asn Leu Ala Ser 
1               5               


<210>  230
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  230

Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   10              


<210>  231
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  231

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser 
1               5                   10  


<210>  232
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 12B12

<400>  232

Glu Ile Tyr Asp Gly Tyr His Phe Ile Tyr 
1               5                   10  


<210>  233
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D11

<400>  233

Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe Tyr Met Glu 
1               5                   10              


<210>  234
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  234

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu 
1               5                   10          


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D11

<400>  235

Thr Arg Asp Thr Gly Pro Met Asp Tyr 
1               5                   


<210>  236
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7E7

<400>  236

His Leu Val Ser Lys Leu Asp Ser 
1               5               


<210>  237
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  237

Ser Phe Ser Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly Ile Gly 
1               5                   10                  15  


<210>  238
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  238

His Ile Val Trp Trp Asp Asp Asn Lys Tyr 
1               5                   10  


<210>  239
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7E7

<400>  239

Ala Arg Asp Gly Gly Tyr Ser Leu Phe Ala Tyr 
1               5                   10      


<210>  240
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  240

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10              


<210>  241
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  241

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser 
1               5                   10  


<210>  242
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 11D5

<400>  242

Lys Ile Tyr Asp Gly Tyr His Phe Asp Tyr 
1               5                   10  


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 13E11

<400>  243

Tyr Ala Ala Ser Asn Leu Gly Ser 
1               5               


<210>  244
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  244

Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Thr Leu His 
1               5                   10              


<210>  245
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  245

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn 
1               5                   10  


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 13E11

<400>  246

Ala Arg His Lys Phe Gly Phe Asp Tyr 
1               5                   


<210>  247
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 1H7

<400>  247

Gln Asp Ile Asn Tyr Tyr 
1               5       


<210>  248
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 and/or 5D12

<400>  248

Gly Tyr Ala Phe Ser Asn Tyr Trp 
1               5               


<210>  249
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  249

Ile Asn Pro Gly Asp Gly Asp Thr 
1               5               


<210>  250
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 6H9

<400>  250

Gln Asp Ile Asn Ile Tyr 
1               5       


<210>  251
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  251

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  252
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  252

Ile Ser Gly Asp Gly Gly Asn Thr 
1               5               


<210>  253
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 9G2

<400>  253

Gln Asp Ile Tyr Asn Tyr 
1               5       


<210>  254
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  254

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  255
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  255

Ile Asn Tyr Asp Gly Gly Ser Thr 
1               5               


<210>  256
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 2D5

<400>  256

Gln Asn Val Gly Thr Asn 
1               5       


<210>  257
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5

<400>  257

Gly Tyr Thr Phe Thr Asp Tyr Asp 
1               5               


<210>  258
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  258

Ile Asp Pro Glu Thr Gly Gly Thr 
1               5               


<210>  259
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 5D12

<400>  259

Gln Asp Ile Lys Ser Tyr 
1               5       


<210>  260
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  260

Ile Tyr Pro Gly Asn Phe Asn Thr 
1               5               


<210>  261
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 3A5v1 and/or 3A5v2

<400>  261

Gln Ser Val Gly Ser Asp 
1               5       


<210>  262
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 3A5v1 and/or 3A5v2

<400>  262

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  263
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  263

Ile Asp Pro Glu Thr Gly Val Thr 
1               5               


<210>  264
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7D5v1 and/or 7D5v2

<400>  264

Gln Asp Ile Phe Asn Tyr 
1               5       


<210>  265
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  265

Gly Phe Ser Leu Thr Ser Tyr Asn 
1               5               


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  266

Ile Trp Thr Gly Gly Asp Thr 
1               5           


<210>  267
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 8F5

<400>  267

Gln Ser Leu Leu Tyr Ser Arg Asn Gln Tyr Asn Phe 
1               5                   10          


<210>  268
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5 and/or 11D11

<400>  268

Gly Phe Thr Phe Ser Asp Phe Tyr 
1               5               


<210>  269
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  269

Ile Ser Asn Ala Gly Val Thr Thr 
1               5               


<210>  270
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 12B12

<400>  270

Gln Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  271
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  271

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  272
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  272

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  273
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D11

<400>  273

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  274
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  274

Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr 
1               5                   10  


<210>  275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 7E7

<400>  275

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  276
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  276

Gly Phe Ser Leu Asn Ser Tyr Gly Met Gly 
1               5                   10  


<210>  277
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  277

Ile Val Trp Trp Asp Asp Asn Lys 
1               5               


<210>  278
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 11D5

<400>  278

Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  279
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  279

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  280
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  280

Ile Tyr Cys Gly Asn Ser Asp Thr 
1               5               


<210>  281
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 13E11

<400>  281

His Gly Val Glu Tyr Ala Gly Ala His Tyr 
1               5                   10  


<210>  282
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  282

Gly Tyr Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  283
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  283

Phe Tyr Pro Thr Ser Gly Ser Ile 
1               5               


<210>  284
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 1H7

<400>  284

Tyr Ser Ser Arg Leu His Ser 
1               5           


<210>  285
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 and/or 5D12

<400>  285

Asn Tyr Trp Met Asn 
1               5   


<210>  286
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  286

Gln Ile Asn Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  287
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 1H7

<400>  287

Glu Asp Arg Asp Tyr Phe Asp Tyr 
1               5               


<210>  288
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  288

Ser Tyr Thr Met Ser 
1               5   


<210>  289
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  289

Thr Ile Ser Gly Asp Gly Gly Asn Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  290
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 6H9

<400>  290

Gln Gly Thr Gly Thr Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  291
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  291

Asp Tyr Tyr Met Ser 
1               5   


<210>  292
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  292

Ser Ile Asn Tyr Asp Gly Gly Ser Thr Tyr Tyr Leu Asp Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  293
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 9G2

<400>  293

Asp Arg Gly Asp Gly Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  294
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 2D5

<400>  294

Ser Ala Ser Asp Arg Tyr Ser 
1               5           


<210>  295
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5

<400>  295

Asp Tyr Asp Met His 
1               5   


<210>  296
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  296

Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 2D5

<400>  297

Asp Tyr Asp Tyr Phe Gly Val 
1               5           


<210>  298
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 3A5v1 and/or 3A5v2

<400>  298

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  299
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 3A5v1 and/or 3A5v2

<400>  299

Asp Tyr Glu Met His 
1               5   


<210>  300
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  300

Ser Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v1

<400>  301

Asp Tyr Gly Tyr Phe Asp Val 
1               5           


<210>  302
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 3A5v2

<400>  302

Asp Tyr Gly Tyr Phe Asn Val 
1               5           


<210>  303
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7D5v1 and/or 7D5v2

<400>  303

Tyr Ala Ser Arg Leu His Ser 
1               5           


<210>  304
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  304

Ser Tyr Asn Ile Asn 
1               5   


<210>  305
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  305

Val Ile Trp Thr Gly Gly Asp Thr Asn Tyr Asn Ser Ala Phe Met Ser 
1               5                   10                  15      


<210>  306
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v1

<400>  306

Asp Gly Thr Gly Thr Gly Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  307
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 7D5v2

<400>  307

Asp Gly Thr Gly Thr Gly Asp His Phe Asp Tyr 
1               5                   10      


<210>  308
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5

<400>  308

Asp Phe Tyr Met Tyr 
1               5   


<210>  309
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  309

Thr Tyr Trp Met His 
1               5   


<210>  310
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  310

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  311
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 12B12

<400>  311

Tyr Asp Gly Tyr His Phe Ile Tyr 
1               5               


<210>  312
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D11

<400>  312

Asp Phe Tyr Met Glu 
1               5   


<210>  313
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  313

Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Lys Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  314
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 7E7

<400>  314

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  315
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  315

Ser Tyr Gly Met Gly Ile Gly 
1               5           


<210>  316
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  316

His Ile Val Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro Asp Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  317
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  317

Ser Tyr Trp Met His 
1               5   


<210>  318
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  318

Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  319
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  319

Asp Tyr Thr Leu His 
1               5   


<210>  320
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 13E11

<400>  320

Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  321
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 1H7 and/or 5D12

<400>  321

Gly Tyr Ala Phe Ser Asn Tyr 
1               5           


<210>  322
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 1H7

<400>  322

Asn Pro Gly Asp Gly Asp 
1               5       


<210>  323
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 6H9

<400>  323

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  324
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 6H9

<400>  324

Ser Gly Asp Gly Gly Asn 
1               5       


<210>  325
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 9G2

<400>  325

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  326
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 9G2

<400>  326

Asn Tyr Asp Gly Gly Ser 
1               5       


<210>  327
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 2D5, 3A5v1, 3A5v2, and/or 13E11

<400>  327

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  328
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 2D5

<400>  328

Asp Pro Glu Thr Gly Gly 
1               5       


<210>  329
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 5D12

<400>  329

Tyr Pro Gly Asn Phe Asn 
1               5       


<210>  330
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 3A5v1 and/or 3A5v2

<400>  330

Asp Pro Glu Thr Gly Val 
1               5       


<210>  331
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7D5v1 and/or 7D5v2

<400>  331

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  332
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7D5v1 and/or 7D5v2

<400>  332

Trp Thr Gly Gly Asp 
1               5   


<210>  333
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 8F5 and/or 11D11

<400>  333

Gly Phe Thr Phe Ser Asp Phe 
1               5           


<210>  334
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 8F5

<400>  334

Ser Asn Ala Gly Val Thr 
1               5       


<210>  335
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 12B12

<400>  335

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  336
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 12B12

<400>  336

Tyr Pro Gly Asn Ser Asp 
1               5       


<210>  337
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D11

<400>  337

Arg Asn Lys Ala Asn Asp Tyr Thr 
1               5               


<210>  338
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 7E7

<400>  338

Gly Phe Ser Leu Asn Ser Tyr Gly Met 
1               5                   


<210>  339
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 7E7

<400>  339

Val Trp Trp Asp Asp Asn 
1               5       


<210>  340
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 11D5

<400>  340

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  341
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 11D5

<400>  341

Tyr Cys Gly Asn Ser Asp 
1               5       


<210>  342
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 13E11

<400>  342

Tyr Pro Thr Ser Gly Ser 
1               5       


<210>  343
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 9G2 and/or 6H9

<400>  343

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  344
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 3A5v1, 3A5v2, and/or 2D5

<400>  344

Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly 
            20  


<210>  345
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 7D5v1 and/or 7D5v2

<400>  345

Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Thr Arg Cys 
            


<210>  346
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain signal peptide of 11D5

<400>  346

Met Arg Phe Ser Ala Gln Leu Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Glu Ser Thr Ala 
            20  


<210>  347
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 6H9

<400>  347

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  348
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 3A5v1 and/or 3A5v2

<400>  348

Met Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Val Ile Ala Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  349
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 7D5v1 and/or 7D5v2

<400>  349

Met Ala Val Leu Ala Leu Leu Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Thr Leu Ser 
            


<210>  350
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 2D5

<400>  350

Met Glu Trp Ser Trp Val Cys Leu Phe Leu Leu Ser Val Ile Ala Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  351
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 11D5

<400>  351

Met Glu Ser Asn Trp Ile Leu Pro Phe Ile Leu Ser Val Thr Ser Gly 
1               5                   10                  15      


Val Tyr Ser 
            


<210>  352
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain signal peptide of 13E11

<400>  352

Met Glu Trp Cys Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  353
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F5 variable light chain

<400>  353

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Tyr Asn Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  354
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8F5 variable heavy chain

<400>  354

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Ala Gly Val Thr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Met Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ser Asp Tyr Asp Gly Ala Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  355
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B12 variable light chain

<400>  355

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  356
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B12 variable heavy chain

<400>  356

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Ser Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ile Tyr Asp Gly Tyr His Phe Ile Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  357
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D11 variable light chain

<400>  357

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  358
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D11 variable heavy chain

<400>  358

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Tyr Lys Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Thr Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  359
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E7 variable light chain

<400>  359

Asp Val Val Met Thr Gln Thr Pro Leu Ile Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile His Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  360
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7E7 variable heavy chain

<400>  360

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Ser Tyr 
            20                  25                  30          


Gly Met Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Val Trp Trp Asp Asp Asn Lys Tyr Tyr Lys Pro 
    50                  55                  60                  


Asp Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Lys Asn Gln 
65                  70                  75                  80  


Val Phe Leu Lys Ile Ala Asn Val Asp Thr Thr Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Gly Gly Tyr Ser Leu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Val 
        115                 120 


<210>  361
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D5 variable light chain

<400>  361

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Asn Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  362
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D5 variable heavy chain

<400>  362

Glu Val Gln Phe Gln Gln Ser Glu Thr Val Leu Ala Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Cys Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Ile Tyr Asp Gly Tyr His Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  363
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E11 variable light chain

<400>  363

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser His Gly Val Glu Tyr Ala 
            20                  25                  30          


Gly Ala His Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gly Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  364
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E11 variable heavy chain

<400>  364

Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Leu His Trp Leu Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Thr Ser Gly Ser Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Lys Phe Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


