                         SEQUENCE LISTING

<110>  ALECTOR LLC
 
<120>  ANTI-MERTK ANTIBODIES AND METHODS OF USE THEREOF

<130>  4503.011PC02

<150>  US 63/003,070
<151>  2020-03-31

<150>  US 63/165,592
<151>  2021-03-24

<160>  243   

<170>  PatentIn version 3.5

<210>  1
<211>  999
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  2
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human MerTK ECD

<400>  2

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile 
            500                 505 


<210>  3
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno MerTK ECD

<400>  3

Met Gly Leu Ala Pro Leu Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu 
1               5                   10                  15      


Pro Ala Leu Trp Ser Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys 
            20                  25                  30          


Pro Tyr Pro Leu Phe Pro Gly Pro Leu Pro Gly Ser Leu Gln Thr Asp 
        35                  40                  45              


His Thr Ser Leu Leu Ser Leu Pro His Thr Ser Gly Tyr Gln Pro Ala 
    50                  55                  60                  


Leu Met Phe Ser Pro Thr Gln Pro Gly Arg Pro Tyr Thr Gly Asn Val 
65                  70                  75                  80  


Ala Ile Pro Arg Val Thr Ser Ala Gly Ser Lys Leu Leu Pro Pro Leu 
                85                  90                  95      


Ala Phe Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Asp 
            100                 105                 110         


Val Lys Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr 
        115                 120                 125             


Thr Ile Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His 
    130                 135                 140                 


Ala Ile Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala 
145                 150                 155                 160 


Ser Phe Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile 
                165                 170                 175     


Cys Lys Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr 
            180                 185                 190         


Ile Glu Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met 
        195                 200                 205             


Asn Val Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly 
    210                 215                 220                 


Pro Pro Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val 
225                 230                 235                 240 


Asn Glu Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu 
                245                 250                 255     


Thr Glu Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu 
            260                 265                 270         


Thr Val Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro 
        275                 280                 285             


Pro Thr Glu Val Ser Ile His Asn Ser Thr Ala His Ser Ile Leu Ile 
    290                 295                 300                 


Ser Trp Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser 
305                 310                 315                 320 


Val Gln Val Lys Glu Val Asp Pro Leu Ser Asn Gly Ser Val Met Ile 
                325                 330                 335     


Phe Asn Thr Ser Ala Ser Pro His Met Tyr Gln Ile Lys Gln Leu Gln 
            340                 345                 350         


Ala Leu Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly 
        355                 360                 365             


Trp Ser Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala 
    370                 375                 380                 


Pro Ser Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Arg 
385                 390                 395                 400 


Asp Asn Val Asp Ile Arg Trp Met Lys Pro Leu Thr Lys Arg Gln Ala 
                405                 410                 415     


Gly Glu Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly 
            420                 425                 430         


Ile Ser Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Asn Ser Arg Ala 
        435                 440                 445             


Gln Ile Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala 
    450                 455                 460                 


Ala Val Thr Lys Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile 
465                 470                 475                 480 


Phe Ile Pro Ala His Gly Trp Val Asp His Ala Pro Ser Ser Thr Pro 
                485                 490                 495     


Ala Pro Gly Asn Ala Asp Pro Val Leu Ile Ile 
            500                 505         


<210>  4
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine MerTK ECD

<400>  4

Met Val Leu Ala Pro Leu Leu Leu Gly Leu Leu Leu Leu Pro Ala Leu 
1               5                   10                  15      


Trp Ser Gly Gly Thr Ala Glu Lys Trp Glu Glu Thr Glu Leu Asp Gln 
            20                  25                  30          


Leu Phe Ser Gly Pro Leu Pro Gly Arg Leu Pro Val Asn His Arg Pro 
        35                  40                  45              


Phe Ser Ala Pro His Ser Ser Arg Asp Gln Leu Pro Pro Pro Gln Thr 
    50                  55                  60                  


Gly Arg Ser His Pro Ala His Thr Ala Ala Pro Gln Val Thr Ser Thr 
65                  70                  75                  80  


Ala Ser Lys Leu Leu Pro Pro Val Ala Phe Asn His Thr Ile Gly His 
                85                  90                  95      


Ile Val Leu Ser Glu His Lys Asn Val Lys Phe Asn Cys Ser Ile Asn 
            100                 105                 110         


Ile Pro Asn Thr Tyr Gln Glu Thr Ala Gly Ile Ser Trp Trp Lys Asp 
        115                 120                 125             


Gly Lys Glu Leu Leu Gly Ala His His Ser Ile Thr Gln Phe Tyr Pro 
    130                 135                 140                 


Asp Glu Glu Gly Val Ser Ile Ile Ala Leu Phe Ser Ile Ala Ser Val 
145                 150                 155                 160 


Gln Arg Ser Asp Asn Gly Ser Tyr Phe Cys Lys Met Lys Val Asn Asn 
                165                 170                 175     


Arg Glu Ile Val Ser Asp Pro Ile Tyr Val Glu Val Gln Gly Leu Pro 
            180                 185                 190         


Tyr Phe Ile Lys Gln Pro Glu Ser Val Asn Val Thr Arg Asn Thr Ala 
        195                 200                 205             


Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro Glu Pro Val Asn Ile 
    210                 215                 220                 


Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu Lys Pro Glu Arg Ser 
225                 230                 235                 240 


Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu Thr Ala Val Phe Ser 
                245                 250                 255     


Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val Ser Lys Gly Val His 
            260                 265                 270         


Ile Asn Ile Lys Val Ile Pro Ser Pro Pro Thr Glu Val His Ile Leu 
        275                 280                 285             


Asn Ser Thr Ala His Ser Ile Leu Val Ser Trp Val Pro Gly Phe Asp 
    290                 295                 300                 


Gly Tyr Ser Pro Leu Gln Asn Cys Ser Ile Gln Val Lys Glu Ala Asp 
305                 310                 315                 320 


Arg Leu Ser Asn Gly Ser Val Met Val Phe Asn Thr Ser Ala Ser Pro 
                325                 330                 335     


His Leu Tyr Glu Ile Gln Gln Leu Gln Ala Leu Ala Asn Tyr Ser Ile 
            340                 345                 350         


Ala Val Ser Cys Arg Asn Glu Ile Gly Trp Ser Ala Val Ser Pro Trp 
        355                 360                 365             


Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser Val Ala Pro Leu Asn 
    370                 375                 380                 


Ile Thr Val Phe Leu Asn Glu Ser Asn Asn Ile Leu Asp Ile Arg Trp 
385                 390                 395                 400 


Thr Lys Pro Pro Ile Lys Arg Gln Asp Gly Glu Leu Val Gly Tyr Arg 
                405                 410                 415     


Ile Ser His Val Trp Glu Ser Ala Gly Thr Tyr Lys Glu Leu Ser Glu 
            420                 425                 430         


Glu Val Ser Gln Asn Gly Ser Trp Ala Gln Ile Pro Val Gln Ile His 
        435                 440                 445             


Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Ile Thr Lys Gly Gly Ile 
    450                 455                 460                 


Gly Pro Phe Ser Glu Pro Val Asn Ile Ile Ile Pro Glu His Ser Lys 
465                 470                 475                 480 


Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro Gly Asn Thr Asp Ser 
                485                 490                 495     


Met 
    


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-201 Heavy Chain Variable

<400>  5

Gln Val Gln Leu Arg Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ile Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ile Lys Asp Asn Ser Arg Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Gly His Asp Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-202 Heavy Chain Variable

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Val Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Gly Gly Ser Asn Thr Ile Tyr Tyr Thr Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asn Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-203 Heavy Chain Variable

<400>  7

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Phe Asp Thr Glu Thr Asn Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ile Pro Ala Asn Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-204 Heavy Chain Variable

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Thr Ser Thr Ile Tyr Tyr Glu Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-206 Heavy Chain Variable

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ile Lys Asn Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Val Tyr Gly Tyr Tyr Gly Ser Ser Pro Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-207 Heavy Chain Variable

<400>  10

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Ile Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ile Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Arg Tyr Gly Asn Tyr Glu Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-208 Heavy Chain Variable

<400>  11

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Val Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Ala Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ser Thr Leu Ser Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Cys Asp Tyr Tyr Gly Arg Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  12
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-209 Heavy Chain Variable

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Phe Asp Ser Glu Pro Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ala Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-210 Heavy Chain Variable

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Glu Phe Ser Arg Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Gly Gly Tyr Tyr Tyr Ser Ile Ser Asn Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-211 Heavy Chain Variable

<400>  14

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Gly Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Cys Cys 
                85                  90                  95      


Ala Arg Gly Glu Pro Ser Tyr Phe Ser Asp Ala Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-212 Heavy Chain Variable

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Val Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Ser Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Ser His Phe Ile Tyr Tyr Thr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Pro Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-213 Heavy Chain Variable

<400>  16

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly His Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ile Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Thr Lys Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  17
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-214 Heavy Chain Variable

<400>  17

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Phe Asp Ser Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Thr Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gly Thr Leu Ile Tyr Trp Gly Gln Gly Thr Thr Leu Thr Ala 
            100                 105                 110         


Ser Ser 
        


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-215 Heavy Chain Variable

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Gly Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Arg Tyr Gly Ala Met Asp Tyr Trp Gly His Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-216 Heavy Chain Variable

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Ile 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Phe His Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-217 Heavy Chain Variable

<400>  20

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ser Gly Ile Asn Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Tyr Tyr Gly Ser Ser Tyr Tyr Val Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-218 Heavy Chain Variable

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Arg Asn Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Leu Ile Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-219 Heavy Chain Variable

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Asn Thr Phe Thr Gly Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Thr Gly Ser Gly Ser Thr Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Phe Thr Asn Ser Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ala 
        115                 


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-220 Heavy Chain Variable

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Gly Gly Ser Gly Thr Ile Tyr Tyr Glu Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-221 Heavy Chain Variable

<400>  24

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Met Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Thr Ser 
    50                  55                  60                  


Leu Gln Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Gly Arg Leu Gly Ala Tyr Ser Ala Phe Pro Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-222 Heavy Chain Variable

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Thr Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Tyr Ser Asn Ser Trp Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ala 
        115                 


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-223 Heavy Chain Variable

<400>  26

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Thr Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Glu Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Ala Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  27
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-224 Heavy Chain Variable

<400>  27

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Phe Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ala Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  28
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-225 Heavy Chain Variable

<400>  28

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Arg Tyr Gly Asn Thr Tyr Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  29
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-226 Heavy Chain Variable

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Asn Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Leu Ile Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  30
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-227 Heavy Chain Variable

<400>  30

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ser Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Phe Pro Pro His Tyr Tyr Ala Gly Gly Tyr Phe Asp 
            100                 105                 110         


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-228 Heavy Chain Variable

<400>  31

Gln Asp Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Asn Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Leu Ile Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  32
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-229 Heavy Chain Variable

<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Glu Phe Ser Arg Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Lys Gly Lys Leu 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Tyr Tyr Tyr Asp Ser Arg Tyr Glu Gly Phe Val 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Val Val Thr Val Ser Ala 
        115                 120                 


<210>  33
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-230 Heavy Chain Variable

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ile Gly Gly Thr Ile Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Phe Ala Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  34
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-201 Light Chain Variable

<400>  34

Gln Ile Val Leu Thr Gln Ser Pro Pro Ile Met Ser Ala Phe Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Arg Gln Met Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His His Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  35
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-202 Light Chain Variable

<400>  35

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Ile Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Phe Phe Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-203 Light Chain Variable

<400>  36

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Gly Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Val Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Ser Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Phe Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-204 Light Chain Variable

<400>  37

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Gln Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Arg Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Phe Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-206 Light Chain Variable

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asn 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Glu Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Asp Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-207 Light Chain Variable

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-208 Light Chain Variable

<400>  40

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Leu Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-209 Light Chain Variable

<400>  41

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Met Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Lys 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Ala Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Val Leu Thr Val Glu Asn Met Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Gly Gly Ala Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-210 Light Chain Variable

<400>  42

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Val Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  43
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-211 Light Chain Variable

<400>  43

Gln Ile Val Leu Thr Gln Ser Pro Ala Val Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Phe Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Met 
            100                 105     


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-212 Light Chain Variable

<400>  44

Asp Ile Val Met Thr Gln Ser His Lys Phe Lys Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ala Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-213 Light Chain Variable

<400>  45

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Asp Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Leu Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-214 Light Chain Variable

<400>  46

Asp Ile Leu Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Thr Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Tyr Lys Lys 
            20                  25                  30          


Leu His Trp Phe Gln Gln Arg Ser His Arg Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Asp Ser Ile Ser Gly Ile Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Ser Ile Asn Ser Val Lys Pro 
65                  70                  75                  80  


Glu Asp Glu Ala Ile Tyr Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-215 Light Chain Variable

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Asn Pro Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Gly Ala 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Leu Gly Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-216 Light Chain Variable

<400>  48

Ser Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Gly Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ala Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Leu Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Phe Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-217 Light Chain Variable

<400>  49

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Asp Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Asp Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-218 Light Chain Variable

<400>  50

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Gln 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-219 Light Chain Variable

<400>  51

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Tyr Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  52
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-220 Light Chain Variable

<400>  52

Asn Ile Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Phe Ser Ser Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  53
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-221 Light Chain Variable

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Lys His 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  54
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-222 Light Chain Variable

<400>  54

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Ser Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Ser Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  55
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-223 Light Chain Variable

<400>  55

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-224 Light Chain Variable

<400>  56

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ile Ile Ser Asp Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-225 Light Chain Variable

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Tyr Leu Lys Ile Asn Gly Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  58
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-226 Light Chain Variable

<400>  58

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Ser Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-227 Light Chain Variable

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Phe Gly Ser Tyr Tyr Cys Gln His Tyr Tyr Arg Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-228 Light Chain Variable

<400>  60

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-229 Light Chain Variable

<400>  61

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Ser Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  62
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-230 Light Chain Variable

<400>  62

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Arg Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-201

<400>  63

Asn Tyr Gly Leu His 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-202

<400>  64

Asp Phe Gly Met His 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1: MTK-203,  MTK-208, MTK-214

<400>  65

Asn Tyr Trp Met His 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1: MTK-204, MTK-215, MTK-216, MTK-220

<400>  66

Asp Tyr Gly Met His 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-206

<400>  67

Ser Tyr Thr Met His 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-207

<400>  68

Ser Tyr Gly Val Ser 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-209

<400>  69

Asn Tyr Trp Ile His 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1: MTK-210, MTK-229

<400>  70

Arg Ser Trp Met Asn 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1: MTK-211, MTK-219, MTK-222

<400>  71

Gly Tyr Trp Ile Glu 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-212

<400>  72

Ser Ser Trp Val Asn 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1: MTK-213, MTK-217

<400>  73

Ser Tyr Trp Ile Thr 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1: MTK-218, MTK-226, MTK-228

<400>  74

Ser Tyr Tyr Ile His 
1               5   


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-221

<400>  75

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-223

<400>  76

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-224

<400>  77

Ser Tyr Trp Met His 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-225

<400>  78

Ala Tyr Asn Met Asp 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-227

<400>  79

Asp Asn Tyr Met Thr 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-230

<400>  80

Asp Tyr Asn Met Asp 
1               5   


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-201

<400>  81

Val Ile Trp Ser Gly Gly Ile Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-202

<400>  82

Phe Ile Ser Gly Gly Ser Asn Thr Ile Tyr Tyr Thr Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-203

<400>  83

Arg Ile His Pro Phe Asp Thr Glu Thr Asn Asp Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-204

<400>  84

Tyr Ile Ser Ser Gly Thr Ser Thr Ile Tyr Tyr Glu Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-206

<400>  85

Tyr Ile Asn Pro Ser Ser Gly Tyr Ile Lys Asn Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  86
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-207

<400>  86

Ile Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile Ser 
1               5                   10                  15      


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-208

<400>  87

Glu Ile Asp Pro Ser Asp Ser Tyr Ala Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-209

<400>  88

Arg Ile His Pro Phe Asp Ser Glu Pro Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-210

<400>  89

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-211

<400>  90

Glu Ile Leu Pro Gly Ser Gly Gly Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-212

<400>  91

Arg Ile Tyr Pro Gly Asp Gly Asp Ser Asn Tyr Asn Gly Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-213

<400>  92

Glu Ile Tyr Pro Gly Ile Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-214

<400>  93

Arg Ile His Pro Phe Asp Ser Asp Thr Asn Tyr Asn Glu Lys Phe Thr 
1               5                   10                  15      


Asp 
    


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-215

<400>  94

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Gly Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-216

<400>  95

Phe Ile Ser Ser Gly Ser Thr Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-217

<400>  96

Asp Ile His Pro Gly Ser Gly Ile Asn Asn Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Ser 
    


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-218

<400>  97

Trp Ile Phe Pro Gly Asn Arg Asn Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-219

<400>  98

Glu Ile Leu Thr Gly Ser Gly Ser Thr Asn Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-220

<400>  99

Phe Ile Ser Gly Gly Ser Gly Thr Ile Tyr Tyr Glu Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-221

<400>  100

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Thr Ser Leu Gln Ser 
1               5                   10                  15      


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-222

<400>  101

Glu Ile Leu Thr Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-223

<400>  102

Tyr Ile Ser Tyr Asp Gly Thr Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-224

<400>  103

Arg Ile His Pro Phe Asp Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-225

<400>  104

Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-226

<400>  105

Trp Ile Phe Pro Gly Asn Gly Asn Thr Lys Tyr Asn Glu Asn Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-227

<400>  106

Phe Ser Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-228

<400>  107

Trp Ile Phe Pro Gly Asn Gly Asn Thr Lys Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-229

<400>  108

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Lys Gly Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-230

<400>  109

Asn Ile Asn Pro Asn Ile Gly Gly Thr Ile Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-201

<400>  110

Lys Gly His Asp Pro Tyr Ala Met Asp Phe 
1               5                   10  


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-202

<400>  111

Asn Gly Asn Ser Phe Ala Tyr 
1               5           


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-203

<400>  112

Pro Ala Asn Gly Gly Phe Ala Tyr 
1               5               


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-204

<400>  113

Gly Gly Leu Leu Phe Asp Tyr 
1               5           


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-206

<400>  114

Thr Val Tyr Gly Tyr Tyr Gly Ser Ser Pro Asp Tyr 
1               5                   10          


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-207

<400>  115

Gly Arg Tyr Gly Asn Tyr Glu Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-208

<400>  116

Cys Asp Tyr Tyr Gly Arg Leu Asp Tyr 
1               5                   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-209

<400>  117

Ala Ser Phe Ala Tyr 
1               5   


<210>  118
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-210

<400>  118

Lys Gly Gly Tyr Tyr Tyr Ser Ile Ser Asn Tyr Phe Asp Tyr 
1               5                   10                  


<210>  119
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-211

<400>  119

Gly Glu Pro Ser Tyr Phe Ser Asp Ala Gly Phe Ala Tyr 
1               5                   10              


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-212

<400>  120

Lys Ser His Phe Ile Tyr Tyr Thr Leu Asp Tyr 
1               5                   10      


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-213

<400>  121

Gly Ala Tyr Thr Lys Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-214

<400>  122

Gly Thr Leu Ile Tyr 
1               5   


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-215

<400>  123

Gly Gly Arg Tyr Gly Ala Met Asp Tyr 
1               5                   


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-216

<400>  124

Gly Gly Phe His Leu Asp Tyr 
1               5           


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-217

<400>  125

Gly Gly Tyr Tyr Gly Ser Ser Tyr Tyr Val Met Asp Tyr 
1               5                   10              


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3: MTK-218, MTK-226, MTK-228

<400>  126

Leu Gly Leu Ile Tyr Ala Leu Asp Tyr 
1               5                   


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-219

<400>  127

Ser Tyr Phe Thr Asn Ser Trp Phe Pro Tyr 
1               5                   10  


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-220

<400>  128

Gly Gly Asn Tyr Phe Asp Tyr 
1               5           


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-221

<400>  129

Leu Gly Ala Tyr Ser Ala Phe Pro Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-222

<400>  130

Ser Tyr Tyr Ser Asn Ser Trp Phe Pro Tyr 
1               5                   10  


<210>  131
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-223

<400>  131

Gly Ala Gly Tyr 
1               


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-224

<400>  132

Ala Gly Phe Ala Tyr 
1               5   


<210>  133
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-225

<400>  133

Arg Arg Arg Tyr Gly Asn Thr Tyr Tyr Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  134
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-227

<400>  134

Phe Pro Pro His Tyr Tyr Ala Gly Gly Tyr Phe Asp Val 
1               5                   10              


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-229

<400>  135

Gly Gly Gly Tyr Tyr Tyr Asp Ser Arg Tyr Glu Gly Phe Val Tyr 
1               5                   10                  15  


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-230

<400>  136

Gly Asp Tyr Gly Phe Ala Ser 
1               5           


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-201

<400>  137

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1: MTK-202, MTK-204, MTK-220

<400>  138

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-203

<400>  139

Ile Thr Ser Thr Asp Ile Gly Asp Asp Met Asn 
1               5                   10      


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-206

<400>  140

Arg Ala Ser Gln Asp Ile Gly Ser Asn Leu Asn 
1               5                   10      


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-207

<400>  141

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-208

<400>  142

Ser Ala Ser Ser Ser Val Ser Tyr Met Leu 
1               5                   10  


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-209

<400>  143

Ile Thr Ser Thr Asp Ile Asp Asp Lys Met Asn 
1               5                   10      


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1: MTK-210, MTK-229

<400>  144

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-211

<400>  145

Ser Ala Ser Ser Ser Ile Thr Tyr Met His 
1               5                   10  


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1: MTK-205, MTK-212

<400>  146

Lys Ala Ser Gln Asp Val Gly Thr Ser Val Ala 
1               5                   10      


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-213

<400>  147

Lys Ala Ser Gln Asp Val Gly Asp Ala Val Ala 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-214

<400>  148

Arg Ala Ser Gln Ser Ile Tyr Lys Lys Leu His 
1               5                   10      


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-215

<400>  149

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  150
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-216

<400>  150

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ala Asn Gln Gln Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-217

<400>  151

Arg Ala Ser Gln Thr Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-218

<400>  152

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly His Thr Tyr Leu His 
1               5                   10                  15      


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-219

<400>  153

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-221

<400>  154

Lys Ala Ser Gln Asp Ile His Lys His Ile Ala 
1               5                   10      


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-222

<400>  155

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Ser Ser Phe Met His 
1               5                   10                  15  


<210>  156
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1: MTK-223, MTK-231

<400>  156

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-224

<400>  157

Arg Ala Ser Gln Ile Ile Ser Asp Tyr Leu Asn 
1               5                   10      


<210>  158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-225

<400>  158

Arg Ala Ser Glu Asn Ile Tyr Ser Ser Leu Ala 
1               5                   10      


<210>  159
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-226

<400>  159

Arg Ser Ser Gln Ser Leu Glu Ser Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-227

<400>  160

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  161
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-228

<400>  161

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-230

<400>  162

Arg Ala Ser Arg Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2: MTK-201, MTK-210

<400>  163

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2: MTK-202, MTK-204, MTK-216, MTK-220

<400>  164

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-203

<400>  165

Glu Gly Asn Ser Leu Arg Pro 
1               5           


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-206

<400>  166

Ala Thr Ser Ser Leu Glu Ser 
1               5           


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-207

<400>  167

Asn Ala Lys Thr Leu Ala Ala 
1               5           


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-208

<400>  168

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-209

<400>  169

Ala Gly Asn Thr Leu Arg Pro 
1               5           


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2: MTK-211, MTK-229

<400>  170

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-212

<400>  171

Trp Ala Ser Ser Arg His Thr 
1               5           


<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2: MTK-213, MTK-232

<400>  172

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-214

<400>  173

Phe Ala Ser Asp Ser Ile Ser 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-215

<400>  174

Asn Pro Ser Gln Ser Ile Ser 
1               5           


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-217

<400>  175

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2: MTK-218, MTK-226, MTK-228

<400>  176

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-219

<400>  177

Arg Ala Tyr Thr Leu Glu Ser 
1               5           


<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-221

<400>  178

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-222

<400>  179

Arg Ala Ser Ser Leu Glu Ser 
1               5           


<210>  180
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2: MTK-223, MTK-231

<400>  180

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-224

<400>  181

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-225

<400>  182

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-227

<400>  183

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-230

<400>  184

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-201

<400>  185

His Gln Tyr His His Ser Pro Tyr Thr 
1               5                   


<210>  186
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-202

<400>  186

His Gln Tyr Phe Phe Ser Trp Thr 
1               5               


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-203

<400>  187

Leu Gln Ser Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3: MTK-204, MTK-216, MTK-220

<400>  188

His Gln Tyr Phe Ser Ser Trp Thr 
1               5               


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-206

<400>  189

Leu Gln Tyr Asp Ser Ser Pro Trp Thr 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-207

<400>  190

Gln His Phe Trp Ser Ile Pro Leu Thr 
1               5                   


<210>  191
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-208

<400>  191

Gln Gln Arg Ser Ser Tyr Pro Pro Ile Thr 
1               5                   10  


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-209

<400>  192

Leu Gln Gly Gly Ala Leu Pro Leu Thr 
1               5                   


<210>  193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-210

<400>  193

Gln Gln Trp Ser Ser Tyr Pro Pro Tyr Thr 
1               5                   10  


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-211

<400>  194

His Gln Arg Ser Thr Tyr Pro Tyr Thr 
1               5                   


<210>  195
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-212

<400>  195

Gln Gln Tyr Ser Thr Tyr Pro Tyr Thr 
1               5                   


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-213

<400>  196

Gln Gln Tyr Ser Ser Tyr Leu Met Tyr Thr 
1               5                   10  


<210>  197
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-214

<400>  197

Leu Gln Gly Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-215

<400>  198

Gln Gln Ser Asn Ser Trp Pro Phe Thr 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-217

<400>  199

Gln Gln Ser Asn Asp Trp Pro Tyr Thr 
1               5                   


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3: MTK-218, MTK-226, MTK-228

<400>  200

Leu Gln Val Thr His Val Pro Phe Thr 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3: MTK-219, MTK-222

<400>  201

Gln Gln Ser Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  202
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-221

<400>  202

Leu Gln Tyr Asp Asn Leu Trp Thr 
1               5               


<210>  203
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-223

<400>  203

Ser Gln Ser Thr His Val Pro Thr Trp Thr 
1               5                   10  


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-224

<400>  204

Gln Asn Gly His Ser Phe Pro Leu Thr 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-225

<400>  205

Gln His Phe Trp Gly Thr Ser Tyr Thr 
1               5                   


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-227

<400>  206

Gln His Tyr Tyr Arg Thr Pro Pro Thr 
1               5                   


<210>  207
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-229

<400>  207

Gln Gln Trp Ser Ser Asn Pro Pro Ile Thr 
1               5                   10  


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-230

<400>  208

Gln His Ser Arg Glu Tyr Pro Phe Thr 
1               5                   


<210>  209
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-231 Heavy Chain Variable

<400>  209

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Thr Tyr Asn Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Thr Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Phe Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  210
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-232 Heavy Chain Variable

<400>  210

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Asn Tyr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  211
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-231 Light Chain Variable

<400>  211

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Ile Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  212
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-232 Light Chain Variable

<400>  212

Asp Ser Val Met Thr Gln Ser His Lys Phe Met Ser Thr Leu Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Tyr Ser Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  213
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-231

<400>  213

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-232

<400>  214

Ser Gly Tyr Trp Asn 
1               5   


<210>  215
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-231

<400>  215

Tyr Ile Ser Tyr Asp Gly Thr Tyr Asn Tyr His Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  216
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-232

<400>  216

Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  217
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-231

<400>  217

Gly Gly Gly Tyr 
1               


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-232

<400>  218

Trp Asn Tyr Leu Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-231

<400>  219

Ser Gln Thr Thr His Ile Pro Leu Thr 
1               5                   


<210>  220
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 MTK-232

<400>  220

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-232

<400>  221

His Gln Tyr Ser Thr Tyr Pro Tyr Thr 
1               5                   


<210>  222
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-205 Heavy Chain Variable

<400>  222

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ile Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Leu Gly Ile Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Glu Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Phe Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Lys Val Ser Ser 
        115         


<210>  223
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTK-205 Light Chain Variable

<400>  223

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg Arg Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  224
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H1 MTK-205

<400>  224

Glu Tyr Ile Met His 
1               5   


<210>  225
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 MTK-205

<400>  225

Gly Ile Asn Pro Asn Asn Leu Gly Ile Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  226
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H3 MTK-205

<400>  226

Asp Gly Tyr Phe Gly Phe Asp Tyr 
1               5               


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L2 MTK-205

<400>  227

Trp Thr Ser Thr Arg Arg Thr 
1               5           


<210>  228
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L3 MTK-205

<400>  228

His Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  229
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal domain (NT) of human MerTK ECD

<400>  229

Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr Pro Leu Phe Pro 
1               5                   10                  15      


Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr Pro Leu Leu Ser 
            20                  25                  30          


Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met Phe Ser Pro Thr 
        35                  40                  45              


Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile Pro Gln Val Thr 
    50                  55                  60                  


Ser Val Glu 
65          


<210>  230
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin-like domain (Ig1) of human MerTK ECD

<400>  230

Ser Lys Pro Leu Pro Pro Leu Ala Phe Lys His Thr Val Gly His Ile 
1               5                   10                  15      


Ile Leu Ser Glu His Lys Gly Val Lys Phe Asn Cys Ser Ile Ser Val 
            20                  25                  30          


Pro Asn Ile Tyr Gln Asp Thr Thr Ile Ser Trp Trp Lys Asp Gly Lys 
        35                  40                  45              


Glu Leu Leu Gly Ala His His Ala Ile Thr Gln Phe Tyr Pro Asp Asp 
    50                  55                  60                  


Glu Val Thr Ala Ile Ile Ala Ser Phe Ser Ile Thr Ser Val Gln Arg 
65                  70                  75                  80  


Ser Asp Asn Gly Ser Tyr Ile Cys Lys Met Lys Ile Asn Asn Glu Glu 
                85                  90                  95      


Ile Val Ser Asp Pro Ile Tyr Ile Glu Val Gln 
            100                 105         


<210>  231
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin-like domain (Ig2) of human MerTK ECD

<400>  231

Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val Thr Arg 
1               5                   10                  15      


Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro Glu Pro 
            20                  25                  30          


Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu Gln Pro 
        35                  40                  45              


Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu Met Ala 
    50                  55                  60                  


Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val Ser Lys 
65                  70                  75                  80  


Gly Val Gln Ile Asn 
                85  


<210>  232
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibronectin type III domain (FN1) of human MerTK ECD

<400>  232

Ile Lys Ala Ile Pro Ser Pro Pro Thr Glu Val Ser Ile Arg Asn Ser 
1               5                   10                  15      


Thr Ala His Ser Ile Leu Ile Ser Trp Val Pro Gly Phe Asp Gly Tyr 
            20                  25                  30          


Ser Pro Phe Arg Asn Cys Ser Ile Gln Val Lys Glu Ala Asp Pro Leu 
        35                  40                  45              


Ser Asn Gly Ser Val Met Ile Phe Asn Thr Ser Ala Leu Pro His Leu 
    50                  55                  60                  


Tyr Gln Ile Lys Gln Leu Gln Ala Leu Ala Asn Tyr Ser Ile Gly Val 
65                  70                  75                  80  


Ser Cys Met Asn Glu Ile Gly Trp Ser Ala Val Ser Pro Trp Ile Leu 
                85                  90                  95      


Ala Ser Thr 
            


<210>  233
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibronectin type III domain (FN2) of human MerTK ECD

<400>  233

Thr Glu Gly Ala Pro Ser Val Ala Pro Leu Asn Val Thr Val Phe Leu 
1               5                   10                  15      


Asn Glu Ser Ser Asp Asn Val Asp Ile Arg Trp Met Lys Pro Pro Thr 
            20                  25                  30          


Lys Gln Gln Asp Gly Glu Leu Val Gly Tyr Arg Ile Ser His Val Trp 
        35                  40                  45              


Gln Ser Ala Gly Ile Ser Lys Glu Leu Leu Glu Glu Val Gly Gln Asn 
    50                  55                  60                  


Gly Ser Arg Ala Arg Ile Ser Val Gln Val His Asn Ala Thr Cys Thr 
65                  70                  75                  80  


Val Arg Ile Ala Ala Val Thr Arg Gly Gly Val Gly Pro Phe Ser Asp 
                85                  90                  95      


Pro Val 
        


<210>  234
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Juxta membrane domain region (JM) of human MerTK ECD

<400>  234

Lys Ile Phe Ile Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser 
1               5                   10                  15      


Thr Pro Ala Pro Gly Asn Ala Asp Pro Val Leu Ile Ile 
            20                  25                  


<210>  235
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal domain (NT) of human Axl ECD

<400>  235

Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val Gly Asn Pro 
1               5                   10                  15      


Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly 
            20                  25          


<210>  236
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin-like domain (Ig1) of human Axl ECD

<400>  236

Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro Pro Glu Val His 
1               5                   10                  15      


Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr 
            20                  25                  30          


Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser 
        35                  40                  45              


Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln 
    50                  55                  60                  


Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr 
65                  70                  75                  80  


Val Gly Leu Glu 
                


<210>  237
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunoglobulin-like domain (Ig2) of human Axl ECD

<400>  237

Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala Ala 
1               5                   10                  15      


Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu Pro 
            20                  25                  30          


Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala Pro 
        35                  40                  45              


Gly His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys Thr 
    50                  55                  60                  


Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr Ser 
65                  70                  75                  80  


Arg Thr Ala Thr Ile Thr Val Leu Pro 
                85                  


<210>  238
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibronectin type III domain (FN1) of human Axl ECD

<400>  238

Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu Leu 
1               5                   10                  15      


Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His 
            20                  25                  30          


Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln Ala 
        35                  40                  45              


Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser Val 
    50                  55                  60                  


Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro Tyr 
65                  70                  75                  80  


His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp Thr 
                85                  90                  95      


His Trp Leu Pro Val Glu Thr Pro Glu Gly 
            100                 105     


<210>  239
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibronectin type III domain (FN2) of human Axl ECD

<400>  239

Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser 
1               5                   10                  15      


Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr 
            20                  25                  30          


Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val 
        35                  40                  45              


Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly 
    50                  55                  60                  


Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala 
65                  70                  75                  80  


Ala Gly Asp Gly Pro Trp Ser 
                85          


<210>  240
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Juxta membrane domain (JM) of human Axl ECD

<400>  240

Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln Pro Val 
1               5                   10                  15      


His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp Pro Trp 
            20                  25                  30          


Trp 
    


<210>  241
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence in MerTK constructs

<400>  241

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  242
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence in Axl constructs

<400>  242

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


<210>  243
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker+His+Avi tag

<400>  243

Gly Gly Ser Gly His His His His His His Gly Gly Gly Leu Asn Asp 
1               5                   10                  15      


Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
            20                  25          


