                         SEQUENCE LISTING

<110>  WUGEN, INC.
 
<120>  ENGINEERED IMMUNE CELLS FOR ADOPTIVE CELL THERAPY

<130>  WGN0009-401-PC

<140>  PCT/US2021/024958
<141>  2021-03-30

<150>  63/001,856
<151>  2020-03-30

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha signal peptide

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  2
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge

<400>  2

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane domain

<400>  3

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  4
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surface glycoprotein CD8 alpha chain isoform 1 precursor 
       (NP_001139345.1)

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  5
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB costimulatory domain

<400>  5

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  6
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 costimulatory domain

<400>  6

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  7

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide

<400>  8

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)4 linker

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  10
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD34

<400>  10

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Ile 
305             


<210>  11
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human-Herpes Simplex Virus-1 (HSV) - thymidine kinase (TK)

<400>  11

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Gly Gly Gly Gly Gly Asp Leu Gly Gly Val 
305                 310                 315                 320 


Lys Leu Pro His Leu Phe Gly Lys Arg Leu Val Glu Ala Arg Met Ala 
                325                 330                 335     


Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala Ala Arg 
            340                 345                 350         


Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln 
        355                 360                 365             


Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr Leu Leu 
    370                 375                 380                 


Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr 
385                 390                 395                 400 


Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro 
                405                 410                 415     


Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr Ile Ala 
            420                 425                 430         


Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala 
        435                 440                 445             


Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly Met 
    450                 455                 460                 


Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly Gly Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Leu Leu Asp 
                485                 490                 495     


Arg His Pro Ile Ala Val Met Leu Cys Tyr Pro Ala Ala Arg Tyr Leu 
            500                 505                 510         


Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile 
        515                 520                 525             


Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu 
    530                 535                 540                 


Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg 
545                 550                 555                 560 


Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu Leu 
                565                 570                 575     


Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp Glu Asp 
            580                 585                 590         


Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala Glu Pro 
        595                 600                 605             


Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu Phe Thr 
    610                 615                 620                 


Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr Asn 
625                 630                 635                 640 


Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg Pro Met 
                645                 650                 655     


His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg Asp 
            660                 665                 670         


Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val Thr Thr 
        675                 680                 685             


Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala Arg 
    690                 695                 700                 


Glu Met Gly Glu Ala Asn 
705                 710 


<210>  12
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 heavy chain variable region (35.1 ATCC HB-222)

<400>  12

Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe Asn Leu Lys Asp Thr 
            20                  25                  30          


Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Lys Trp Ile Gly 
        35                  40                  45              


Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
    50                  55                  60                  


Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Ala Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 light chain variable region (35.1 ATCC HB-222)

<400>  13

Asp Ile Lys Asn Ile Thr Gln Ser Pro Ser Ser Met Tyr Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser 
            20                  25                  30          


Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu 
        35                  40                  45              


Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105                 


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 heavy chain variable region (OKT 11 ATCC CRL-8027)

<400>  14

Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 light chain variable region (OKT 11 ATCC CRL-8027)

<400>  15

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110         


Arg 
    


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 heavy chain variable region (OKT3)

<400>  16

Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 light chain variable region (OKT 3)

<400>  17

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  18
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 heavy chain variable region (UCHT1)

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 heavy chain variable region (UCHT1)

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD7 heavy chain variable region

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  21
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD7 light chain variable region

<400>  21

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL3 heavy chain variable region (EB10)

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Gly Ala His Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL3 light chain variable region (EB10)

<400>  23

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Pro Ala Ile Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL3 heavy chain variable region (NC7)

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Phe Ala Leu Phe Gly Phe Arg Glu Gln Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL3 light chain variable region (NC7)

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  26
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL3 heavy chain variable region (D3-D4)

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Ala Ala Ala Val Ala Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  27
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FTL3 light chain variable region (D3-D4)

<400>  27

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS1 heavy chain variable region

<400>  28

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS1 light chain variable region

<400>  29

Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  30
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 heavy chain variable region

<400>  30

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ser Gly 
        115                 120 


<210>  31
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 light chain variable region

<400>  31

Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser 
1               5                   10                  15      


Pro Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe 
            20                  25                  30          


Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro 
        35                  40                  45              


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
    50                  55                  60                  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys 
                85                  90                  95      


His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg 
        115 


<210>  32
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 heavy chain variable region

<400>  32

Leu Lys Pro Arg Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp 
            20                  25                  30          


Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Ile Gly Glu Ile Asn Leu Asp Ser Ser Thr Ile Asn Tyr 
    50                  55                  60                  


Thr Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala 
                85                  90                  95      


Leu Tyr Tyr Cys Ala Arg Arg Tyr Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Ala Ser Gln 
145                 150             


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 light chain variable region

<400>  33

Ala Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            20                  25                  30          


Asp Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Pro Asn Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn 
65                  70                  75                  80  


Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln 
                85                  90                  95      


Ser Lys Asp Val Arg Trp Arg His Gln Ala Gly Asp Gln Thr Gly 
            100                 105                 110     


<210>  34
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 heavy chain variable region

<400>  34

Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Met His Val Trp Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  35
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 light chain variable region

<400>  35

Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Met His Val Trp Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  36
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMCP Amino Acid Sequence

<400>  36

Met His Leu Gln Tyr Tyr Ala Ile Ser Leu Val Ser Leu Val Ser Leu 
1               5                   10                  15      


Ile Asp Cys His Lys Leu Ala Phe Asn Phe Asn Leu Glu Ile Asn Gly 
            20                  25                  30          


Ser Asp Thr His Ser Thr Val Asp Val Tyr Leu Asp Asp Ser Gln Ile 
        35                  40                  45              


Ile Thr Phe Asp Gly Lys Asp Ile Arg Pro Thr Ile Pro Phe Met Ile 
    50                  55                  60                  


Gly Asp Glu Ile Phe Leu Pro Phe Tyr Lys Asn Val Phe Ser Glu Phe 
65                  70                  75                  80  


Phe Ser Leu Phe Arg Arg Val Pro Thr Ser Thr Pro Tyr Glu Asp Leu 
                85                  90                  95      


Thr Tyr Phe Tyr Glu Cys Asp Tyr Thr Asp Asn Lys Ser Thr Phe Asp 
            100                 105                 110         


Gln Phe Tyr Leu Tyr Asn Gly Glu Glu Tyr Thr Val Lys Thr Gln Glu 
        115                 120                 125             


Ala Thr Asn Lys Asn Met Trp Leu Thr Thr Ser Glu Phe Arg Leu Lys 
    130                 135                 140                 


Lys Trp Phe Asp Gly Glu Asp Cys Ile Met His Leu Arg Ser Leu Val 
145                 150                 155                 160 


Arg Lys Met Glu Asp Ser Lys Arg Asn Thr Gly 
                165                 170     


