                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Kulp, Dan
 
<120>  Synthetic Soluble Receptor Mimics and Methods of Use for 
       Treatment of COVID-19

<130>  206193-0030-00WO

<150>  US 63/001,882
<151>  2020-03-30

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  2625
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, Ace2_IgHu_pVax

<400>  1
atggactgga cttggaggat cttgttcttg gtggctgcag ccaccgggac gcacgccaag       60

agtaccatag aggagcaggc caaaaccttc ttggacaagt tcaaccatga agctgaagat      120

ttgttttacc agtcttctct tgcctcctgg aactacaata ctaatataac cgaggaaaat      180

gttcagaata tgaacaacgc cggggacaaa tggtcagcat ttctcaaaga gcagtctact      240

cttgcgcaaa tgtaccccct ccaggaaatc cagaatctga ccgttaaatt acaattgcag      300

gctctgcagc aaaacggatc ctcagtcttg tctgaagata agtcaaaacg tctcaatacc      360

atattgaata ccatgtctac tatctactcc acgggcaagg tctgcaaccc cgacaaccct      420

caggagtgtc tgttgctcga acccggcctg aatgaaatca tggcgaactc tctggattac      480

aatgaacgcc tctgggcgtg ggagagctgg aggtccgagg tgggcaagca gttgcgacca      540

ctgtacgaag agtacgtggt gctgaaaaac gaaatggctc gtgcaaatca ctatgaggac      600

tacggggatt actggagggg ggattatgag gttaacggtg ttgacgggta tgattactct      660

agaggccaac tgatcgaaga tgtagagcac acgttcgaag agatcaagcc actctatgaa      720

cacctgcacg catacgttcg cgccaagctg atgaacgctt acccaagtta catcagccca      780

attggctgtc tgcctgctca tctgctgggg gacatgtggg gaaggttctg gactaatctt      840

tacagcctga cagtcccttt cggtcagaaa ccaaacatcg acgttacgga cgctatggtc      900

gatcaagcct gggatgcaca gcggatcttt aaagaggctg aaaagttttt tgtctcagtc      960

ggattgccca acatgacgca gggtttctgg gagaatagca tgctgaccga tcctgggaat     1020

gtgcagaaag cagtttgcca ccccactgct tgggacttgg gcaagggtga ctttcgcata     1080

ctcatgtgta ccaaggtgac catggacgac tttttaactg ctcatcacga gatgggccac     1140

atacagtacg acatggcata cgctgcacag ccatttctcc tcaggaacgg agcaaacgag     1200

ggcttccacg aggccgtcgg cgagatcatg agcttgagtg cagcgactcc caaacatctc     1260

aaatctatcg gccttctgtc tccggacttt caggaagata atgagacaga aataaatttt     1320

ttactgaagc aagcactgac cattgtcggc acccttccgt tcacgtacat gctggagaaa     1380

tggcgttgga tggtcttcaa aggagagatt cccaaagacc agtggatgaa gaaatggtgg     1440

gagatgaaga gagagatagt cggggtcgtg gagcccgtgc cccatgacga aacttattgt     1500

gatcccgcca gtctctttca tgtttccaat gattatagct tcatcaggta ctacacacgc     1560

acactctatc agttccagtt tcaggaagcc ttatgccagg cagccaagca cgagggccca     1620

cttcacaaat gcgacatcag caatagcaca gaagccggac agaaactttt taacatgctt     1680

cgtttaggga agagcgaacc atggactttg gctctggaaa acgtggtggg cgctaaaaac     1740

atgaatgtgc ggcccttgct caattacttt gaacctcttt ttacttggct gaaagaccag     1800

aacaagaact ctttcgtggg ctggagcact gattggtctc catatgctga cgccgctgac     1860

ccagagccca agagctgtga caaaacccat acatgccccc catgccctgc ccctgagctg     1920

ctcggcggcc cctccgtgtt cttgttccct ccgaaaccac ccaaggacac cctgatgatt     1980

agcagaaccc cagaggtaac ttgcgtcgtg gtggatgtct ctcatgagga tccggaggtt     2040

aagttcaatt ggtatgtgga cggcgtggag gtgcataacg ctaaaaccaa gcctagggag     2100

gagcagtaca actccactta tagggtcgtg tccgtgctga cagtgctgca tcaggattgg     2160

ttaaacggaa aagagtacaa atgcaaggta tctaacaagg ctctccctgc gcctattgag     2220

aagacaatca gtaaagcaaa agggcagcct agagagcccc aggtttacac attgcccccc     2280

agtcgagatg agctgactaa aaatcaagtc tcccttacct gcttggttaa agggttttat     2340

ccatcagaca tcgcggtcga gtgggaaagt aatggacagc ctgaaaataa ttacaaaact     2400

accccccccg ttcttgatag cgatggctcc ttcttcctgt acagcaagct tacagtggat     2460

aaaagtagat ggcagcaagg aaacgttttt agttgctcag tgatgcacga agccctgcat     2520

aatcattaca cccaaaagag tctgagtttg tctccgggca aaggcggcgg cggaggagat     2580

tatgccgatt acgacggagg ttattattac gacatggact aatag                     2625


<210>  2
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, Ace2_IgHu_pVax

<400>  2

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Lys Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          


Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              


Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  


Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  


Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      


Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         


Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             


Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 


Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 


Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     


Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         


Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             


Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 


Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 


His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     


Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         


Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             


Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 


Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 


Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     


Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         


Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             


Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 


Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 


Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     


Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         


Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             


Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 


Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 


Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     


Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         


Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             


Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 


Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 


Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     


Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         


Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             


Ser Thr Asp Trp Ser Pro Tyr Ala Asp Ala Ala Asp Pro Glu Pro Lys 
    610                 615                 620                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
625                 630                 635                 640 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                645                 650                 655     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            660                 665                 670         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        675                 680                 685             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    690                 695                 700                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
705                 710                 715                 720 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                725                 730                 735     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            740                 745                 750         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        755                 760                 765             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    770                 775                 780                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
785                 790                 795                 800 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                805                 810                 815     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            820                 825                 830         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        835                 840                 845             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    850                 855                 860                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
865                 870             


<210>  3
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v1_IgHu_pVax

<400>  3
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcatccacg       60

atcgaagaac aggctaaaac atttctggac aaatttaatc acgaagccga agatcttttc      120

tatcaaagca gccttgctag ttggaactat aacaacaata tcacagagga aaacgtacaa      180

aacatgaaca atgctgggga taaatggtct gcattcctga aagaacaatc cacactggct      240

caaatgtacc cacttcaaga aattcaaaat ctgacggtga aactgcaact ccaaggcggc      300

tccggtagcg gtgggtctgg tagcggcggt tccggaagtg gcggttctgt gtgtcatccc      360

accgcatggg acttggggaa gggtgatttt cgcattttga tgtgtggtgg cgccgctgat      420

ccggaaccca agagttgtga taagacccac acctgcccgc cttgccctgc tcccgaactt      480

ttgggcggcc cttctgtgtt tctctttccc ccaaaaccac ccaaagacac acttatgata      540

agccggaccc ccgaagtcac ttgtgtggtg gttgacgtat ctcatgagga cccagaggtc      600

aaatttaatt ggtacgtgga tggcgtcgaa gtgcataacg ctaaaactaa gccccgtgaa      660

gagcaatata acagcacata tagggtagtc agtgtcctga cagtgttgca tcaagattgg      720

ctcaatggaa aggagtacaa gtgtaaggtt tccaataaag ccctgccagc ccccattgag      780

aaaactatct caaaggctaa gggacaaccg agagagcctc aggtgtacac cctgccgccc      840

agccgtgacg agcttacaaa gaatcaggta agtttgacgt gcctcgttaa aggcttttat      900

ccttccgaca ttgccgtcga atgggaatct aatggacagc cagagaataa ctataagacc      960

acaccaccgg tcttggattc agatggaagc ttcttcttgt atagtaaact cactgtcgac     1020

aaaagtcgat ggcaacaggg gaacgtcttt agttgttctg ttatgcatga ggcccttcat     1080

aatcattaca cacaaaagtc actttctttg agccctggga agggtggcgg cggcggggat     1140

tatgctgatt acgacggcgg atactactac gatatggact agtga                     1185


<210>  4
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v1_IgHu_pVax

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
        115                 120                 125             


Asp Phe Arg Ile Leu Met Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    370                 375                 380                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
385                 390             


<210>  5
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v2_IgHu_pVax

<400>  5
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcaagcacc       60

attgaggaac aagccaaaac attcctggat aagttcaacc atgaagcgga agatcttttc      120

taccaaagtt cacttgcttc ctggaattac aataataaca tcacagaaga aaacgtgcag      180

aacatgaata atgccggcga caaatggtcc gcctttctca aggagcaaag cactcttgcg      240

caaatgtacc cactgcaaga gatccagaac cttacagtaa aattgcaact ccaaggtggg      300

tccggatctg gcggcagtgg ttccggcggt tcaggaagcg gtggtagttg tactgcctgg      360

gatctgggca agggcgattt tcgcatcctg tgcggcggag cagcggaccc ggagcccaaa      420

agttgtgata agacccacac ctgtccccca tgtcctgccc cagagctttt gggtggtcct      480

agcgtgttcc ttttcccgcc gaaaccgcca aaggacacac ttatgatctc tcgtaccccc      540

gaagtcacat gtgttgtcgt agacgtgtcc cacgaggacc cagaagtgaa atttaactgg      600

tatgtcgacg gcgtggaagt acacaatgcg aaaactaaac caagggaaga acaatataat      660

tccacatatc gtgtggtaag tgttctcaca gtcctgcatc aggactggct gaacgggaag      720

gaatacaagt gtaaggttag taacaaagct cttccggccc ccattgaaaa gaccatctcc      780

aaagcgaaag gccaacccag agaaccgcag gtgtacactt tgccgcccag cagagacgag      840

ttgactaaga atcaagtctc actcacttgc ctggtcaagg gcttctatcc ttccgacatt      900

gcagttgaat gggaatccaa cggacaaccg gaaaataact ataaaacaac accaccggtg      960

ctcgatagtg acggatcttt cttcctttat agcaaactca ccgttgacaa gtcccgctgg     1020

cagcagggga acgtcttttc ctgtagtgtg atgcacgagg ctcttcacaa tcattacacg     1080

cagaaatctc tgagtctcag tcccgggaaa ggtggggggg gcggagatta tgcggactac     1140

gatggcgggt actactacga tatggattga tag                                  1173


<210>  6
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v2_IgHu_pVax

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Cys Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg 
        115                 120                 125             


Ile Leu Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys Ser Cys Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp Thr Leu Met Ile 
                165                 170                 175     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            180                 185                 190         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        195                 200                 205             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    210                 215                 220                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
225                 230                 235                 240 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                245                 250                 255     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        355                 360                 365             


Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr Asp Gly Gly Tyr 
    370                 375                 380                 


Tyr Tyr Asp Met Asp 
385                 


<210>  7
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v3_IgHu_pVax

<400>  7
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcatcaacc       60

attgaagaac aggccaaaac tttcctcgac aagtttaatc acgaggcaga agatctgttt      120

tatcaaagtt ccctcgcgag ctggaactac aataacaata tcacagaaga aaacgtacag      180

aatatgaata acgcaggcga taaatggtct gcatttctca aagaacaatc tacgctggcg      240

caaatgtacc ctctccaaga gatacaagcc cttaccgtta agctccagct gcaaggcggc      300

tccggttccg gcggtagcgg ctctggtggt agcgggagcg gtggatctgt gtgtcatcca      360

actgcatggg acctgggaaa aggggatttt cggattctca tgtgcggtgg tgccgccgac      420

ccagagccca agtcttgtga caagacccat acttgcccac cctgtcctgc tcccgaactg      480

ctgggtggcc cttctgtatt ccttttccca ccaaaaccac ctaaggatac tcttatgatc      540

agcagaacac ccgaagtaac atgtgtggtg gtcgatgtgt ctcacgaaga tccagaagtg      600

aagtttaatt ggtatgtcga tggcgtggaa gtacataatg ccaaaacgaa gccccgggaa      660

gaacagtata attctaccta tagagtggtt tctgtgttga ccgtgctcca tcaggattgg      720

ctgaacggta aggaatacaa gtgtaaggtt tctaataagg cactccctgc cccgatagag      780

aaaacaattt ccaaggctaa ggggcaaccc agagagccac aagtctatac cttgccccca      840

tcacgggacg aacttacgaa gaatcaagta tcccttacct gcctggtcaa aggattttat      900

cccagtgata tagccgttga atgggagtct aacggccaac ccgagaataa ttataagaca      960

acaccgccgg tattggactc agatggctcc ttctttctgt acagcaagct gacggtagac     1020

aagagccgct ggcaacaagg gaacgtcttt agttgttctg tcatgcacga agcccttcac     1080

aatcactata cacagaaatc tctgtctttg agtcccggga aaggaggagg aggaggagac     1140

tatgctgatt atgatggcgg atattactat gatatggatt aatag                     1185


<210>  8
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v3_IgHu_pVax

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
        115                 120                 125             


Asp Phe Arg Ile Leu Met Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    370                 375                 380                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
385                 390             


<210>  9
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v4_IgHu_pVax

<400>  9
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcaagcacg       60

atagaggagc aagccaaaac cttccttgat aagtttaatc atgaggcaga ggatctgttc      120

taccaaagct ccctcgcttc ctggaattat aataataaca ttaccgaaga gaatgttcaa      180

aacatgaata atgctgggga taagtggtca gccttcctca aagaacaatc caccctggcc      240

caaatgtatc ctctgcaaga gattcaagcc ctgacagtca aactccagct gcaaggcggc      300

agcggctccg gtggcagtgg atcaggcgga tcaggctcag gcggctcttg tactgcatgg      360

gatcttggca agggtgattt cagaatcctt tgtggcggag ctgcggaccc cgagcctaag      420

tcctgcgata aaacccatac atgcccgcca tgccctgccc cagagttgct gggtgggccg      480

agcgtgtttc tcttcccacc caaaccccca aaagacacac tgatgatatc ccgtacgcca      540

gaagtgactt gtgttgtcgt tgacgtgtca catgaagatc ctgaagtgaa atttaattgg      600

tatgttgatg gcgtcgaggt acataacgcg aaaacaaaac ccagggaaga gcaatacaat      660

tccacataca gagttgtttc tgtgttgact gtgttgcatc aggattggct caatggcaag      720

gaatacaagt gcaaggtctc caataaagct ctccctgccc ccattgaaaa gacaatatct      780

aaagccaagg ggcaacctcg cgaaccgcag gtgtacacct tgcctccctc cagagacgaa      840

ctgaccaaga atcaagttag tttgacgtgt cttgtgaagg gattctatcc ctcagatatc      900

gcggtcgaat gggagagtaa tgggcaaccg gaaaataact ataagacaac cccgcccgtc      960

ctcgatagcg atggatcatt cttcctgtat agcaagctga ctgtggacaa aagcagatgg     1020

caacaaggta acgtcttctc atgttcagtt atgcacgagg cgctccacaa tcattatacc     1080

cagaaaagtt tgtctctcag tccaggcaaa ggtggtggtg gtggtgatta cgctgactac     1140

gacggtggtt actattacga tatggactaa tga                                  1173


<210>  10
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v4_IgHu_pVax

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Cys Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg 
        115                 120                 125             


Ile Leu Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys Ser Cys Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp Thr Leu Met Ile 
                165                 170                 175     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            180                 185                 190         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        195                 200                 205             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    210                 215                 220                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
225                 230                 235                 240 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                245                 250                 255     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        355                 360                 365             


Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr Asp Gly Gly Tyr 
    370                 375                 380                 


Tyr Tyr Asp Met Asp 
385                 


<210>  11
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v5_IgHu_pVax

<400>  11
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcatctacc       60

attgaagaac aggcgaaata tttcttggac aagttcaatg tcgaagctga ggacttgttt      120

tataagagta gccttgcttc ttggaattac aataacaaca taacagaaga gaacgttcag      180

aatatgaaca acgccggcga caaatggagt gcatttctca aagaacaatc cacgttggca      240

caaatgtatc cgttgcagga aatacaagct ctgaccgtca agcttcaact tcaaggcggc      300

tctgggtccg gtggcagtgg gtctggtgga tctgggtcag gcggctcagt ttgccatcct      360

acggcctggg acctcgggaa aggggatttt cggatactta tgtgtggtgg ggcagccgat      420

cctgagccta agtcctgcga taagactcac acgtgtccac catgcccggc tcccgaactc      480

ctcggtggcc catcagtgtt cctctttcca cctaagccac ctaaagacac gcttatgatt      540

tctcgcactc cagaagtgac atgtgttgtt gtagacgtta gtcacgaaga ccctgaggtg      600

aagtttaatt ggtacgtgga cggagtggaa gttcataatg ccaagactaa gcctagagaa      660

gagcagtaca attctaccta cagggtggta agcgttctca cggttctcca tcaagactgg      720

cttaatggaa aagagtataa atgcaaagtg agtaacaagg ctcttcctgc cccaattgag      780

aagaccatta gtaaagcgaa aggtcagcct agagagccgc aggtctacac tctgccacct      840

agtcgagatg aactcactaa gaatcaagtc agtttgacat gtctcgtaaa gggcttctac      900

ccaagtgata tcgcggtgga gtgggagtcc aacggtcagc cagaaaacaa ctacaagacc      960

acaccccctg tgctcgattc agatggctca ttctttctct acagtaagct gacagttgat     1020

aaaagtagat ggcaacaagg caacgtcttt tcttgctctg tcatgcatga agcccttcac     1080

aaccattata cacaaaagtc attgagcctg agtcctggca agggaggagg cggcggcgat     1140

tatgccgatt acgacggcgg ttactattac gacatggatt agtaa                     1185


<210>  12
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v5_IgHu_pVax

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Val Glu Ala Glu Asp Leu Phe Tyr Lys Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
        115                 120                 125             


Asp Phe Arg Ile Leu Met Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    370                 375                 380                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
385                 390             


<210>  13
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v6_IgHu_pVax

<400>  13
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcatccact       60

atagaggaac aagcgaaata cttcctggac aagttcaatg cggaagccga agacctgttt      120

tatatgtcat ctctggccag ctggaactat aacaacaaca ttacggaaga gaacgtgcaa      180

aacatgaaca atgccggcga caaatggtct gcattcctga aagaacaatc cacccttgca      240

caaatgtacc ctctccaaga aatacaagca ctgacagtca agctgcagct gcaaggtgga      300

tctggttctg gcggaagcgg atctggtggc agtgggagtg gtggttccgt atgtcatcct      360

acagcctggg atctcgggaa aggggatttc cgtatcctta tgtgcggcgg ggcagccgat      420

cctgagccaa aatcctgcga caaaacacat acatgtccac cctgtccggc ccccgagctt      480

ctgggtggtc catctgtatt cctgtttccc cctaaaccac ctaaggatac cctcatgatc      540

agccggaccc ccgaagtcac atgtgtggtg gtggacgtgt cacacgaaga cccggaagtc      600

aaattcaatt ggtacgtcga tggagtcgaa gtacataatg ccaaaactaa accgcgagag      660

gagcagtata acagtactta tcgcgtggtc agtgtcctga ccgtcctgca ccaagattgg      720

ctgaatggaa aagagtataa atgcaaggta agcaacaaag ccctgccagc gccaattgag      780

aaaactatca gcaaagccaa gggacagcca agagaaccac aagtgtacac cttgccgccc      840

agtagggatg aactcacgaa gaatcaagtg agcttgacct gcttggtcaa aggcttttat      900

ccttcagaca tagcggtgga gtgggaatcc aacggccagc ccgaaaataa ctataaaact      960

accccacctg tacttgatag tgacggcagc ttcttcttgt actccaagct gaccgtggat     1020

aaatctcgat ggcaacaagg gaacgtcttc agctgttcag taatgcatga ggcactgcat     1080

aatcactata cacaaaagag tctctctttg tccccaggaa agggtggtgg aggaggtgat     1140

tacgccgact acgatggcgg gtattattat gatatggatt gataa                     1185


<210>  14
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v6_IgHu_pVax

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Tyr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Met Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
        115                 120                 125             


Asp Phe Arg Ile Leu Met Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    370                 375                 380                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
385                 390             


<210>  15
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v7_IgHu_pVax

<400>  15
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcaagtacc       60

atcgaagagc aagctaaact gttcctggat aaattcaatg tcgaggccga agatctcttc      120

tatatgtcat ccctcgcttc ctggaattat aataacaata ttactgaaga gaatgtacag      180

aacatgaata atgccggaga taaatggtcc gcttttctga aggagcaatc cacacttgcc      240

caaatgtatc cgctccaaga aatacaagcg cttacggtta aactccaact gcaaggtggc      300

tctggctcag gcggctctgg aagcggtggc tcagggtcag gtggctccgt gtgtcaccca      360

accgcatggg atctgggcaa gggagatttt cgaattctta tgtgcggcgg cgctgcagac      420

cctgaaccca aaagctgtga taaaactcac acctgcccgc catgtccagc acccgaactc      480

ttgggcggcc ccagtgtctt ccttttccca ccaaaacccc ctaaggatac tctgatgatc      540

tcacggactc cagaggtaac ctgtgtggtg gtcgacgtgt cacacgagga cccggaagtt      600

aaatttaatt ggtacgtcga tggagttgag gtgcataatg ctaaaactaa acctcgggaa      660

gaacagtaca attcaactta tcgagtcgtg agtgtgctca ctgtccttca ccaagactgg      720

ttgaacggga aggaatacaa gtgcaaagtc agtaacaaag cgctccccgc ccctatcgag      780

aagactatct ctaaggccaa agggcaaccc agggagcctc aggtttatac gctgccacca      840

tcccgggatg aactgaccaa gaaccaagta agcttgacct gtcttgtgaa gggtttctat      900

ccttccgata ttgcggtaga atgggaaagc aatggacaac cggaaaataa ttataaaacc      960

actccgcccg ttcttgattc cgacggatca ttctttctgt atagcaaact gaccgtggat     1020

aagtctagat ggcagcaagg gaacgtgttc agttgctctg taatgcacga agcattgcat     1080

aatcattaca cgcaaaagtc cctctctttg agccccggca agggaggagg aggaggagac     1140

tatgctgatt atgacggtgg ctactactat gacatggact aatag                     1185


<210>  16
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v7_IgHu_pVax

<400>  16

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Leu Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Val Glu Ala Glu Asp Leu Phe Tyr Met Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
        115                 120                 125             


Asp Phe Arg Ile Leu Met Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    370                 375                 380                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
385                 390             


<210>  17
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v8_IgHu_pVax

<400>  17
atggactgga cctggatact ctttctcgta gcagcagcca cacgagtgca ttcatcaact       60

atagaagaac aagccaaact gtttctcgac aagttcaatg ctgaagcaga agatctgttc      120

tataaatctt cccttgcgtc atggaattac aacaataaca ttacggaaga aaacgtccag      180

aacatgaaca atgctggcga caaatggtct gcatttctga aagaacagtc tacattggcg      240

cagatgtatc cattgcagga gatacaggct ctcactgtaa agctccaact gcagggtgga      300

agcggctccg gtgggtccgg cagtggcggt agtggaagtg gtggttccgt ctgccaccca      360

acagcttggg atttgggtaa aggggacttt aggatactta tgtgtggcgg ggctgccgac      420

ccagagccta agtcctgtga taaaacgcac acctgcccgc cctgtcccgc acccgagctg      480

ctgggtggcc catcagtatt cctgtttcca cccaagcccc cgaaggatac tctgatgatt      540

tcacgtactc ccgaagtaac ttgtgtggta gtcgatgtgt cacacgaaga tcccgaggtg      600

aaatttaact ggtacgtgga cggggttgag gtgcacaatg cgaaaactaa gccccgggaa      660

gagcagtata actctactta ccgagtggtg agcgtcctca ccgtgctcca ccaagactgg      720

ctgaacggca aggagtataa atgtaaggtt agcaataagg ccctgccagc tccaattgag      780

aaaaccatca gcaaggccaa agggcagccc cgcgagcccc aggtgtacac gctgccgcct      840

agcagagatg agctgactaa gaatcaggtc tctcttacct gtttggtgaa gggcttttac      900

cctagcgaca ttgccgtgga atgggagtcc aacggccagc ctgaaaacaa ttacaagaca      960

actcccccgg tcttggatag tgacgggagc ttcttccttt actccaagct gacagtcgac     1020

aagtctagat ggcagcaagg gaacgtcttc agctgtagcg ttatgcacga ggccctgcac     1080

aatcattata cgcagaaatc tctttctttg tctcccggta aggggggggg cggcggggat     1140

tatgctgatt atgatggtgg ctattattat gatatggact aatga                     1185


<210>  18
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, minACE2_v8_IgHu_pVax

<400>  18

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Ile Glu Glu Gln Ala Lys Leu Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn Ala Glu Ala Glu Asp Leu Phe Tyr Lys Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Asn Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Ala Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Ser Gly Gly Ser Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
        115                 120                 125             


Asp Phe Arg Ile Leu Met Cys Gly Gly Ala Ala Asp Pro Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp 
                165                 170                 175     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            180                 185                 190         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        195                 200                 205             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    210                 215                 220                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
225                 230                 235                 240 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                245                 250                 255     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            260                 265                 270         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        275                 280                 285             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    290                 295                 300                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
305                 310                 315                 320 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                325                 330                 335     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            340                 345                 350         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        355                 360                 365             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
    370                 375                 380                 


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
385                 390             


