                         SEQUENCE LISTING

<110>  NORTH CAROLINA STATE UNIVERSITY
       COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
 
<120>  ENGINEERED BACTERIA FOR USE IN VACCINE COMPOSITIONS

<130>  NCSU-39278.601

<150>  63/002,260
<151>  2020-03-30

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys 
1               5                   10                  15  


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln 
1               5                   10                  15      


Ser 
    


<210>  4
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu 
1               5                   10                  15      


Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile Leu Thr Arg 
            20                  25                  30          


Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly 
        35                  40                  45              


His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp Ile Lys Asp 
    50                  55                  60                  


Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr 
65                  70                  75                  80  


Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly Phe Ala Ala 
                85                  90                  95      


Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His Ser 
            100                 105                 110         


Ser Ser Ser Asp Asn Ile Ala Leu Val Gln Leu Glu His 
        115                 120                 125 


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ala Ser Leu Ile Tyr Arg Gln Leu Leu 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Thr Glu Ala Ser Thr Gln Ile Asn Asp Gly 
1               5                   10  


<210>  7
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Gly Ala Glu Lys Thr Gln Asn Val Thr Val Asn Pro Gly Pro Phe 
1               5                   10                  15      


Ala Gln Thr Gly Tyr Ala Pro Ala Asn Trp Gly Pro Gly Glu Thr Asn 
            20                  25                  30          


Asp Thr Thr Val Glu Pro Val Leu Asp Gly Pro Tyr Gln Pro Ile Ala 
        35                  40                  45              


Phe Ser Pro Pro Pro Glu Tyr Tyr Ile Leu Leu Ser Pro Thr Ala Pro 
    50                  55                  60                  


Gly Val Ile Ala Glu Cys Thr Asn Thr Val Asn Arg Trp Ile Ala Ile 
65                  70                  75                  80  


Ile Ala Ile Glu Pro Asn Val Ser Pro Thr Asn Arg Thr Tyr Thr Leu 
                85                  90                  95      


Phe Gly Ile Thr Glu Gln Leu Thr Val Glu Asn Ser Ser Val Asp Lys 
            100                 105                 110         


Trp Lys Phe Ile Asp Phe Met Lys Thr Pro Thr Thr Gly Ser Tyr Val 
        115                 120                 125             


Arg Tyr Asn Ile Leu Leu Ser Ser Thr Lys Leu Cys Ala Val Ala Lys 
    130                 135                 140                 


His Thr Asp Asn Leu Tyr Ser Tyr Val Gly Glu Thr Pro Thr Ala Gly 
145                 150                 155                 160 


Gln Ala Tyr Tyr Ser Ser Phe Asn Ile Phe Asn Leu Thr Ala His Cys 
                165                 170                 175     


Asp Phe Tyr Ile Ile Pro Trp Ser Gln Gln Ser Leu Cys Thr Gln Tyr 
            180                 185                 190         


Val Asn Asn Gly Leu Pro Pro Ile Gln Asn Thr Arg Asn Val 
        195                 200                 205     


<210>  8
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Tyr Gly Ile Glu Tyr Thr Thr Ile Leu Ile Phe Leu Ile Ser Ile 
1               5                   10                  15      


Ile Leu Leu Asn Tyr Ile Leu Lys Ser Val Thr Arg Met Met Asp Tyr 
            20                  25                  30          


Ile Ile Tyr Arg Ser Leu Leu Ile Ser Val Ala Leu Phe Ala Leu Thr 
        35                  40                  45              


Arg Ala Gln Asn Tyr Gly Ile Asn Leu Pro Ile Thr Gly Ser Met Asp 
    50                  55                  60                  


Ala Ala Tyr Ala Asn Ser Thr Gln Glu Gly Ile Phe Leu Thr Ser Thr 
65                  70                  75                  80  


Leu Cys Leu Tyr Tyr Pro Thr Glu Ala Ser Thr Gln Ile Asn Asp Gly 
                85                  90                  95      


Glu Trp Lys Asp Ser Leu Ser Gln Met Phe Leu Ile Lys Gly Trp Pro 
            100                 105                 110         


Thr Gly Ser Val Tyr Phe Lys Glu Tyr Ser Ser Ile Val Asp Phe Ser 
        115                 120                 125             


Val Asp Pro Gln Leu Tyr Cys Asp Tyr Asn Leu Val Leu Met Lys Tyr 
    130                 135                 140                 


Asp Gln Asp Leu Glu Leu Asp Met Ser Glu Leu Ala Asp Leu Ile Leu 
145                 150                 155                 160 


Asn Glu Trp Leu Cys Asn Pro Met Asp Ile Thr Leu Tyr Tyr Tyr Gln 
                165                 170                 175     


Gln Ser Gly Glu Ser Asn Lys Trp Ile Ser Met Gly Ser Ser Cys Thr 
            180                 185                 190         


Val Lys Val Cys Pro Leu Asn Thr Gln Thr Leu Gly Ile Gly Cys Gln 
        195                 200                 205             


Thr Thr Asn Val Asp Ser Phe Glu Met Val Ala Glu Asn Glu Lys Leu 
    210                 215                 220                 


Ala Ile Val Asp Val Val Asp Gly Ile Asn His Lys Ile Asn Leu Thr 
225                 230                 235                 240 


Thr Thr Thr Cys Thr Ile Arg Asn Cys Lys Lys Leu Gly Pro Arg Glu 
                245                 250                 255     


Asn Val Ala Val Ile Gln Val Gly Gly Ser Asn Val Leu Asp Ile Thr 
            260                 265                 270         


Ala Asp Pro Thr Thr Asn Pro Gln Thr Glu Arg Met Met Arg Val Asn 
        275                 280                 285             


Trp Lys Lys Trp Trp Gln Val Phe Tyr Thr Ile Val Asp Tyr Ile Asn 
    290                 295                 300                 


Gln Ile Val Gln Val Met Ser Lys Arg Ser Arg Ser Leu Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Tyr Tyr Arg Val 
                325     


<210>  9
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ala Ser Leu Ile Tyr Arg Gln Leu Leu Thr Asn Ser Tyr Ser Val 
1               5                   10                  15      


Asp Leu His Asp Glu Ile Glu Gln Ile Gly Ser Glu Lys Thr Gln Asn 
            20                  25                  30          


Val Thr Ile Asn Pro Ser Pro Phe Ala Gln Thr Arg Tyr Ala Pro Val 
        35                  40                  45              


Asn Trp Gly His Gly Glu Ile Asn Asp Ser Thr Thr Val Glu Pro Ile 
    50                  55                  60                  


Leu Asp Gly Pro Tyr Gln Pro Thr Thr Phe Thr Pro Pro Asn Asp Tyr 
65                  70                  75                  80  


Trp Ile Leu Ile Asn Ser Asn Thr Asn Gly Val Val Tyr Glu Ser Thr 
                85                  90                  95      


Asn Asn Ser Asp Phe Trp Thr Ala Val Val Ala Ile Glu Pro His Val 
            100                 105                 110         


Asn Pro Val Asp Arg Gln Tyr Thr Ile Phe Gly Glu Ser Lys Gln Phe 
        115                 120                 125             


Asn Val Ser Asn Asp Ser Asn Lys Trp Lys Phe Leu Glu Met Phe Arg 
    130                 135                 140                 


Ser Ser Ser Gln Asn Glu Phe Tyr Asn Arg Arg Thr Leu Thr Ser Asp 
145                 150                 155                 160 


Thr Arg Phe Val Gly Ile Leu Lys Tyr Gly Gly Arg Val Trp Thr Phe 
                165                 170                 175     


His Gly Glu Thr Pro Arg Ala Thr Thr Asp Ser Ser Ser Thr Ala Asn 
            180                 185                 190         


Leu Asn Asn Ile Ser Ile Thr Ile His Ser Glu Phe Tyr Ile Ile Pro 
        195                 200                 205             


Arg Ser Gln Glu Ser Lys Cys Asn Glu Tyr Ile Asn Asn Gly Leu Pro 
    210                 215                 220                 


Pro Ile Gln Asn Thr Arg Asn Val Val Pro Leu Pro Leu Ser Ser Arg 
225                 230                 235                 240 


Ser Ile Gln Tyr Lys Arg Ala Gln Val Asn Glu Asp Ile Ile Val Ser 
                245                 250                 255     


Lys Thr Ser Leu Trp Lys Glu Met Gln Tyr Asn Arg Asp Ile Ile Ile 
            260                 265                 270         


Arg Phe Lys Phe Gly Asn Ser Ile Val Lys Met Gly Gly Leu Gly Tyr 
        275                 280                 285             


Lys Trp Ser Glu Ile Ser Tyr Lys Ala Ala Asn Tyr Gln Tyr Asn Tyr 
    290                 295                 300                 


Leu Arg Asp Gly Glu Gln Val Thr Ala His Thr Thr Cys Ser Val Asn 
305                 310                 315                 320 


Gly Val Asn Asn Phe Ser Tyr Asn Gly Gly Ser Leu Pro Thr Asp Phe 
                325                 330                 335     


Gly Ile Ser Arg Tyr Glu Val Ile Lys Glu Asn Ser Tyr Val Tyr Val 
            340                 345                 350         


Asp Tyr Trp Asp Asp Ser Lys Ala Phe Arg Asn Met Val Tyr Val Arg 
        355                 360                 365             


Ser Leu Ala Ala Asn Leu Asn Ser Val Lys Cys Thr Gly Gly Ser Tyr 
    370                 375                 380                 


Asn Phe Ser Ile Pro Val Gly Ala Trp Pro Val Met Asn Gly Gly Ala 
385                 390                 395                 400 


Val Ser Leu His Phe Ala Gly Val Thr Leu Ser Thr Gln Phe Thr Asp 
                405                 410                 415     


Phe Val Ser Leu Asn Ser Leu Arg Phe Arg Phe Ser Leu Thr Val Asp 
            420                 425                 430         


Glu Pro Pro Phe Ser Ile Leu Arg Thr Arg Thr Val Asn Leu Tyr Gly 
        435                 440                 445             


Leu Pro Ala Ala Asn Pro Asn Asn Gly Asn Glu Tyr Tyr Glu Ile Ser 
    450                 455                 460                 


Gly Arg Phe Ser Leu Ile Tyr Leu Val Pro Thr Asn Asp Asp Tyr Gln 
465                 470                 475                 480 


Thr Pro Ile Met Asn Ser Val Thr Val Arg Gln Asp Leu Glu Arg Gln 
                485                 490                 495     


Leu Thr Asp Leu Arg Glu Glu Phe Asn Ser Leu Ser Gln Glu Ile Ala 
            500                 505                 510         


Met Ala Gln Leu Ile Asp Leu Ala Leu Leu Pro Leu Asp Met Phe Ser 
        515                 520                 525             


Met Phe Ser Gly Ile Lys Ser Thr Ile Asp Leu Thr Lys Ser Met Ala 
    530                 535                 540                 


Thr Ser Val Met Lys Lys Phe Arg Lys Ser Lys Leu Ala Thr Ser Ile 
545                 550                 555                 560 


Ser Glu Met Thr Asn Ser Leu Ser Asp Ala Ala Ser Ser Ala Ser Arg 
                565                 570                 575     


Asn Val Ser Ile Arg Ser Asn Leu Ser Ala Ile Ser Asn Trp Thr Asn 
            580                 585                 590         


Val Ser Asn Asp Val Ser Asn Val Thr Asn Ser Leu Asn Asp Ile Ser 
        595                 600                 605             


Thr Gln Thr Ser Thr Ile Ser Lys Lys Phe Arg Leu Lys Glu Met Ile 
    610                 615                 620                 


Thr Gln Thr Glu Gly Met Ser Phe Asp Asp Ile Ser Ala Ala Val Leu 
625                 630                 635                 640 


Lys Thr Lys Ile Asp Met Ser Thr Gln Ile Gly Lys Asn Thr Leu Pro 
                645                 650                 655     


Asp Ile Val Thr Glu Ala Ser Glu Lys Phe Ile Pro Lys Arg Ser Tyr 
            660                 665                 670         


Arg Ile Leu Lys Asp Asp Glu Val Met Glu Ile Asn Thr Glu Gly Lys 
        675                 680                 685             


Phe Phe Ala Tyr Lys Ile Asn Thr Phe Asp Glu Val Pro Phe Asp Val 
    690                 695                 700                 


Asn Lys Phe Ala Glu Leu Val Thr Asp Ser Pro Val Ile Ser Ala Ile 
705                 710                 715                 720 


Ile Asp Phe Lys Thr Leu Lys Asn Leu Asn Asp Asn Tyr Gly Ile Thr 
                725                 730                 735     


Arg Thr Glu Ala Leu Asn Leu Ile Lys Ser Asn Pro Asn Met Leu Arg 
            740                 745                 750         


Asn Phe Ile Asn Gln Asn Asn Pro Ile Ile Arg Asn Arg Ile Glu Gln 
        755                 760                 765             


Leu Ile Leu Gln Cys Lys Leu 
    770                 775 


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Lys Lys His Gln Arg Arg Ser Arg Arg Ser Thr Thr Thr Ser Ile Asn 
1               5                   10                  15      


Thr Tyr 
        


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Pro Ile Ile Gly Lys Arg Ser Ala Val Glu Asp Leu Leu Phe Asn Lys 
1               5                   10                  15      


Val Val 
        


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Leu Tyr Arg Arg Thr Lys Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn 
1               5                   10                  15      


Ala Ile Leu Cys Ile Asn Ala Leu Gly Arg Asn Tyr Ile Leu Pro Leu 
            20                  25                  30          


Asp Gly Thr Pro Thr Gly Val Thr Leu Thr Leu Leu Ser Gly Asn Leu 
        35                  40                  45              


Tyr Ala Glu Gly Phe Lys Met Ala Gly Gly Leu Thr Ile Asp His Leu 
    50                  55                  60                  


Pro Lys Tyr Val Met Ile Ala Thr Pro Ser Arg Thr Ile Val Tyr Thr 
65                  70                  75                  80  


Leu Val Gly Lys Gln Leu Lys Ala Thr Thr Ala Thr Gly Trp Ala Tyr 
                85                  90                  95      


Tyr Val Lys Ser Lys Ala Gly Asp Tyr Ser Thr Glu Ala Arg Thr Asp 
            100                 105                 110         


Asn Leu Ser Glu His Glu Lys Leu Leu His Met Val 
        115                 120                 


<210>  13
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
1               5                   10                  15      


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            20                  25                  30          


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        35                  40                  45              


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    50                  55                  60                  


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
65                  70                  75                  80  


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                85                  90                  95      


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            100                 105                 110         


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
        115                 120                 125             


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
    130                 135                 140                 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
145                 150                 155                 160 


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
                165                 170                 175     


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
            180                 185                 190         


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
        195                 200                 205             


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
    210                 215                 220                 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
225                 230                 235                 240 


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
                245                 250                 255     


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
            260                 265                 270         


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
        275                 280                 285             


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala 
    290                 295                 300                 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
305                 310                 315                 320 


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
                325                 330                 335     


Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
            340                 345                 350         


Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
        355                 360                 365             


Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
    370                 375                 380                 


Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
385                 390                 395                 400 


Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
                405                 410                 415     


Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
            420                 425                 430         


Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
        435                 440                 445             


Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
    450                 455                 460                 


Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
465                 470                 475                 480 


Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
                485                 490                 495     


Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
            500                 505                 510         


Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro 
        515                 520                 525             


Trp 
    


<210>  14
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Pro 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Asn Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Thr Leu Asn Val Gln 
                165                 170                 175     


Gln Lys Tyr Lys Val Ser Asp Thr Ala Ala Thr Val Thr Gly Tyr Ala 
            180                 185                 190         


Asp Thr Thr Ile Ala Leu Asp Asn Ser Thr Phe Lys Ala Ser Ala Thr 
        195                 200                 205             


Gly Leu Gly Gly Thr Asp Gln Lys Ile Asp Gly Asp Leu Lys Phe Asp 
    210                 215                 220                 


Asp Thr Thr Gly Lys Tyr Tyr Ala Lys Val Thr Val Thr Gly Gly Thr 
225                 230                 235                 240 


Gly Lys Asp Gly Tyr Tyr Glu Val Ser Val Asp Lys Thr Asn Gly Glu 
                245                 250                 255     


Val Thr Leu Ala Gly Gly Ala Thr Ser Pro Leu Thr Gly Gly Leu Pro 
            260                 265                 270         


Ala Thr Ala Thr Glu Asp Val Lys Asn Val Gln Val Ala Asn Ala Asp 
        275                 280                 285             


Leu Thr Glu Ala Lys Ala Ala Leu Thr Ala Ala Gly Val Thr Gly Thr 
    290                 295                 300                 


Ala Ser Val Val Lys Met Ser Tyr Thr Asp Asn Asn Gly Lys Thr Ile 
305                 310                 315                 320 


Asp Gly Gly Leu Ala Val Lys Ile Gly Asp Asp Tyr Tyr Ser Ala Thr 
                325                 330                 335     


Gln Asn Lys Asp Gly Ser Ile Ser Ile Asn Thr Thr Lys Tyr Thr Ala 
            340                 345                 350         


Asp Asp Gly Thr Ser Lys Thr Ala Leu Asn Lys Leu Gly Gly Ala Asp 
        355                 360                 365             


Gly Lys Thr Glu Val Val Ser Ile Gly Gly Lys Thr Tyr Ala Ala Ser 
    370                 375                 380                 


Lys Ala Glu Gly His Asn Phe Lys Ala Gln Pro Asp Leu Ala Glu Ala 
385                 390                 395                 400 


Ala Ala Thr Thr Thr Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu 
                405                 410                 415     


Ala Gln Val Asp Thr Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg 
            420                 425                 430         


Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Thr 
        435                 440                 445             


Ser Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser 
    450                 455                 460                 


Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly 
465                 470                 475     


<210>  15
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Phe Ala Cys Lys Thr Ala Asn Gly Thr Ala Ile Pro Ile Gly Gly Gly 
1               5                   10                  15      


Ser Ala Asn Val Tyr Val Asn Leu Ala Pro Val Val Asn Val Gly Gln 
            20                  25                  30          


Asn Leu Val Val Asp Leu Ser Thr Gln Ile Phe Cys His Asn Asp Tyr 
        35                  40                  45              


Pro Glu Thr Ile Asp Tyr Val Thr Leu Gln Ser Ala Tyr Gly Gly Val 
    50                  55                  60                  


Leu Ser Asn Phe Ser Gly Thr Val Lys Tyr Ser Gly Ser Ser Tyr Pro 
65                  70                  75                  80  


Phe Pro Thr Thr Ser Glu Thr Pro Arg Val Val Tyr Asn Ser Arg Thr 
                85                  90                  95      


Asp Lys Pro Trp Pro Val Ala Leu Tyr Leu Thr Pro Val Ser Ser Ala 
            100                 105                 110         


Gly Gly Val Ala Ile Lys Ala Gly Ser Leu Ile Ala Val Leu Ile Leu 
        115                 120                 125             


Arg Gln Thr Asn Asn Tyr Asn Ser Asp Asp Phe Gln Phe Val Trp Asn 
    130                 135                 140                 


Ile Tyr Ala Asn Asn Asp Val Val Val Pro Thr Gly Gly 
145                 150                 155         


<210>  16
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Phe Ala Cys Lys Thr Ala Asn Gly Thr Ala Ile Pro Ile Gly Gly Gly 
1               5                   10                  15      


Ser Ala Asn Val Tyr Val Asn Leu Ala Pro Val Val Asn Val Gly Gln 
            20                  25                  30          


Asn Leu Val Val Asp Leu Ser Thr Gln Ile Phe Cys His Asn Asp Tyr 
        35                  40                  45              


Pro Glu Thr Ile Thr Asp Tyr Val Thr Leu Gln Arg Gly Ser Ala Tyr 
    50                  55                  60                  


Gly Gly Val Leu Ser Asn Phe Ser Gly Thr Val Lys Tyr Ser Gly Ser 
65                  70                  75                  80  


Ser Tyr Pro Phe Pro Thr Thr Ser Glu Thr Pro Arg Val Val Tyr Asn 
                85                  90                  95      


Ser Arg Thr Asp Lys Pro Trp Pro Val Ala Leu Tyr Leu Thr Pro Val 
            100                 105                 110         


Ser Ser Ala Gly Val Ala Ile Lys Ala Gly Ser Leu Ile Ala Val Leu 
        115                 120                 125             


Ile Leu Arg Gln Thr Asn Asn Tyr Asn Ser Asp Asp Phe Gln Phe Val 
    130                 135                 140                 


Trp Asn Ile Tyr Ala Asn Asn Asp Val Val Val Pro Thr Gly Gly Cys 
145                 150                 155                 160 


Asp Val Ser Ala Arg Asp Val Thr Val Thr Leu Pro Asp Tyr Pro Gly 
                165                 170                 175     


Ser Val Pro Ile Pro Leu Thr Val Tyr Cys Ala Lys Ser Gln Asn Leu 
            180                 185                 190         


Gly Tyr Tyr Leu Ser Gly Thr Thr Ala Asp Ala Gly Asn Ser Ile Phe 
        195                 200                 205             


Thr Asn Thr Ala Ser Phe Ser Pro Ala Gln Gly Val Gly Val Gln Leu 
    210                 215                 220                 


Thr Arg Asn Gly Thr Ile Ile Pro Ala Asn Asn Thr Val Ser Leu Gly 
225                 230                 235                 240 


Ala Val Gly Thr Ser Ala Val Ser Leu Gly Leu Thr Ala Asn Tyr Ala 
                245                 250                 255     


Arg Thr Gly Gly Gln Val Thr Ala Gly Asn Val Gln Ser Ile Ile Gly 
            260                 265                 270         


Val Thr Phe Val Tyr Gln 
        275             


