                         SEQUENCE LISTING

<110>  University of Rochester
       Kobie, James J.
       Martinez-Sobrido, Luis
       Piepenbrink, Michael
       Nogales, Aitor
 
<120>  Broadly Neutralizing Monoclonal Antibodies against the 
       Hemagglutinin (HA) and Neuraminidase (NA) of Influenza H3N2 
       Viruses and Uses Thereof

<130>  161118.02501

<150>  63/003,471
<151>  2020-04-01

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Gly Phe Thr Phe Ala Ser Asp Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Ile Ser Gly Asn Gly Gly Ile Thr 
1               5               


<210>  3
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Ala Lys Gly Val Ala Pro Ser His Phe Asn Leu Leu Thr Gly Tyr Tyr 
1               5                   10                  15      


Ala Gly His Tyr Tyr Phe Asp Phe 
            20                  


<210>  4
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Gln Ser Val Arg His Asn 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Gly Ala Ser 
1           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Gln Gln Tyr Asn His Trp Pro Pro Tyr Thr 
1               5                   10  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Gly Tyr Ser Phe Thr Arg Tyr Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Ile Ser Ala Tyr Thr Gly Asn Thr 
1               5               


<210>  9
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Ala Arg Asp Leu Pro Gln Gly Val Val Ile Leu Gly Ser Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Gln Ser Val Thr Ser Arg Tyr 
1               5           


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Gln Gln Ser Gly Ser Pro Arg Thr 
1               5               


<210>  12
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Ala Arg Asp His Pro Gln Gly Val Val Ile Leu Gly Ser Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Gly Tyr Ser Phe Thr Ser Gln Ser 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Ile Asn Pro Ser Gly Gly Ile Thr 
1               5               


<210>  15
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Val Arg Asp Leu Ser His Tyr Asn Glu Val Gly His Asp Arg Ala Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Ile 
            20          


<210>  16
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Lys Leu Gly Lys Lys Tyr 
1               5       


<210>  17
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Gln Asp Asn 
1           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Gln Ala Trp Asp Ser Ser Ala Val Val 
1               5                   


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Gly Phe Thr Phe Ser Gly Tyr Ala 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Ile Ile Gly Ser Gly Gly Ser Thr 
1               5               


<210>  21
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Ala Lys His Thr Lys Ser His Tyr Tyr Ser Gly Met Gly Val 
1               5                   10                  


<210>  22
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Asp Ala Ala 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  25
<211>  394
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  25
gaggtgcagc tgttggagtc tgggggaggc ttggttcagc ctggggggtc cctgagactc       60

tcctgtacag cctctggatt cacgtttgcc agcgatgcca tgaactgggt ccgccaggct      120

ccagggaagg gcctggagtg ggtctcagct attagtggta atggtggtat cacatacttc      180

gcagactccg tgaagggccg gttcaccatc tcccgagaca attccaagga cacgctctat      240

ctgcaaatgg acagcctgag ggccgaggac acggccgtat attactgtgc aaaaggggtc      300

gcaccctcac atttcaatct tttgactggt tattatgcgg gacactacta ctttgacttc      360

tggggccagg gaaccctggt caccgtctcc tcag                                  394


<210>  26
<211>  131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ala Ser Asp 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asn Gly Gly Ile Thr Tyr Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Ala Pro Ser His Phe Asn Leu Leu Thr Gly Tyr Tyr 
            100                 105                 110         


Ala Gly His Tyr Tyr Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  27
<211>  325
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  27
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttcgt cacaacttag cctggtacca gcacaaacct      120

ggccagcctc ccaggctcct catctatggt gcatccacta gggccgctag tgtcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataatcact ggcctccgta cacttttggc      300

caggggacca agctggagat caaac                                            325


<210>  28
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg His Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Ala Ser Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn His Trp Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  29
<211>  381
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  29
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cctctggtta cagttttacc agatatggta ttagctgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggatgg atcagcgctt acactggtaa cacagactat      180

gcacagaagt ttcagggcag aatcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgttt attactgtgc gagagatctc      300

cctcagggag tagttatatt aggctcctat tactacggta tggacgtctg gggccaaggg      360

aacacggtca ccgtctcctc a                                                381


<210>  30
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Pro Gln Gly Val Val Ile Leu Gly Ser Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Asn Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  31
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  31
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttacc agtaggtact tagcctggta ccagcaaaaa      120

cttggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagtctggag      240

cctgaagatc ttgcagttta ttactgtcag cagtctggta gcccacggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  32
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Ser Gly Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  381
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  33
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cctctggtta cagctttacc agatatggta taagctgggt gcgacaggcc      120

cctggacaag gccttgagtg gatgggatgg atcagcgctt acactggtaa cacagactat      180

gcacagaaat ttcagggcag aatcaccatg accacagaca catccacgag cacagtctac      240

atggagctga ggagcctaag atctgacgac acggccgtgt attactgtgc gagagatcac      300

cctcagggag tagttatatt aggctcctat tactacggta tggacgtctg gggccaaggg      360

aacacggtca ccgtctcctc a                                                381


<210>  34
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Pro Gln Gly Val Val Ile Leu Gly Ser Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Asn Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  35
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  35
gaaattgtgt tgacgcagtc tccgggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttacc agtaggtact tagcctggta ccagcaaaaa      120

cttggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagtctggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtctggta gcccacggac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  36
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Gly Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  387
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  37
caggtgcagc tggtgcagtc tggggctgag gtgagcaagc ctggggcctc agtgaaggtc       60

tcctgcaagg catctggata cagcttcacc agccagtctc taggctgggt gcggcaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtat cacaaactac      180

gcacacaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacggtctac      240

atggagctga gcagcctgag atctgaggac acggccctgt attactgtgt gagagatttg      300

agtcattaca atgaagtggg acatgacagg gcctactact acggtatgga catctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210>  38
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ser Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Gln 
            20                  25                  30          


Ser Leu Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ile Thr Asn Tyr Ala His Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Ser His Tyr Asn Glu Val Gly His Asp Arg Ala Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  39
<211>  319
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  39
tcctatgagc tgattcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgttctg gagataaatt ggggaaaaaa tatacttgct ggtatcagca gaagccaggc      120

cagtcccctg tgctggtcat ctatcaggat aacaagcggc cctcagggat ccctgagcgg      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagcg ctgtggtatt cggcggaggg      300

accaagctga ccgtcctgg                                                   319


<210>  40
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  40

Ser Tyr Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Lys Lys Tyr Thr 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Ala Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  41
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  41
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg cgtctcaggt attattggta gtggtggaag cacatactcc      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctggat      240

ctggaaatga acagcctgag agccgaggac acggccgtat attattgtgc gaaacatacc      300

aaatcccact actattccgg aatgggcgtc tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  42
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ser Gly Ile Ile Gly Ser Gly Gly Ser Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asp 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Thr Lys Ser His Tyr Tyr Ser Gly Met Gly Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  43
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagagacca      120

gggaaagccc ctaaactcct gatctacgat gcagccaatt tggaaacagg ggtcccatca      180

aggttcagcg gaagtggatc tgcgacacag tttactttca ccatcagcgg cctgcagcct      240

gaagattttg caacatatta ctgtcaacag tatgataatc tccctctcac tttcggcggc      300

gggaccaagg tggaaatcaa ac                                               322


<210>  44
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ala Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Gln Phe Thr Phe Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


