                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
       Avalon GloboCare Corp.
       ZHANG, Shuguang
       JIN, David
       QING, Rui
       SLEYTR, Uwe
 
<120>  QTY FC Fusion Water Soluble GPCR Proteins

<130>  4041.3048 WO

<140>  PCT/US21/23808
<141>  2021-03-24

<150>  US63/048,716
<151>  2020-07-07

<150>  US63/002,661
<151>  2020-03-31

<160>  341   

<170>  PatentIn version 3.5

<210>  1
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  2
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 Varient

<400>  2

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Thr 
        35                  40                  45              


Tyr Ser Thr Thr Tyr Gln Thr Gly Thr Thr Gly Asn Gly Gln Thr Thr 
    50                  55                  60                  


Gln Thr Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Gln His Gln Ser Thr Ala Asp Gln Gln Tyr Thr Thr Thr Gln Pro 
                85                  90                  95      


Tyr Trp Ala Thr Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Thr His Thr Thr Tyr Thr Thr Asn Gln Tyr Ser Ser Thr 
        115                 120                 125             


Gln Thr Gln Ala Tyr Thr Ser Gln Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Thr Thr 
145                 150                 155                 160 


Tyr Thr Gly Thr Trp Thr Pro Ala Gln Gln Gln Thr Thr Pro Asp Tyr 
                165                 170                 175     


Thr Tyr Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Tyr Gln Tyr Gln His Thr 
        195                 200                 205             


Met Thr Gly Gln Thr Gln Pro Gly Thr Thr Thr Gln Ser Cys Tyr Cys 
    210                 215                 220                 


Thr Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Thr Thr Gln Thr Gln Ala Tyr Tyr Ala Cys Trp 
                245                 250                 255     


Gln Pro Tyr Tyr Thr Gly Thr Ser Thr Asp Ser Tyr Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Thr 
        275                 280                 285             


Ser Thr Thr Glu Ala Gln Ala Tyr Tyr His Cys Cys Gln Asn Pro Thr 
    290                 295                 300                 


Gln Tyr Ala Tyr Gln Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  3
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC1

<400>  3

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys 
        35              


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  4

Ile Phe Leu Pro Thr Thr Tyr Ser Thr Thr Phe Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Val Thr Gln Val Met 
            20                  25  


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  5

Ile Phe Gln Pro Thr Thr Tyr Ser Thr Thr Phe Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Val Thr Gln Val Met 
            20                  25  


<210>  6
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  6

Ile Phe Gln Pro Thr Thr Tyr Ser Thr Thr Phe Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Val Thr Gln Thr Met 
            20                  25  


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  7

Ile Phe Gln Pro Thr Thr Tyr Ser Thr Thr Tyr Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Val Thr Gln Thr Met 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  8

Ile Phe Gln Pro Thr Thr Tyr Ser Thr Thr Tyr Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Thr Thr Gln Val Met 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  9

Ile Phe Gln Pro Thr Thr Tyr Ser Thr Thr Tyr Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Thr Ile Gln Thr Met 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  10

Ile Phe Gln Pro Thr Thr Tyr Ser Thr Thr Tyr Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Thr Thr Gln Thr Met 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM1 Variant

<400>  11

Thr Tyr Gln Pro Thr Thr Tyr Ser Thr Thr Tyr Gln Thr Gly Thr Thr 
1               5                   10                  15      


Gly Asn Gly Gln Thr Thr Gln Thr Met 
            20                  25  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IC1

<400>  12

Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg 
1               5                   10                  


<210>  13
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  13

Leu His Leu Ser Thr Ala Asp Gln Gln Phe Thr Thr Thr Gln Pro Phe 
1               5                   10                  15      


Trp Ala Val Asp Ala Val 
            20          


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  14

Leu His Leu Ser Val Ala Asp Gln Gln Tyr Thr Thr Thr Gln Pro Phe 
1               5                   10                  15      


Trp Ala Thr Asp Ala Val 
            20          


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  15

Leu His Gln Ser Val Ala Asp Gln Gln Tyr Val Thr Thr Gln Pro Phe 
1               5                   10                  15      


Trp Ala Thr Asp Ala Thr 
            20          


<210>  16
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  16

Gln His Gln Ser Val Ala Asp Gln Gln Phe Thr Thr Thr Gln Pro Phe 
1               5                   10                  15      


Trp Ala Thr Asp Ala Thr 
            20          


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  17

Leu His Gln Ser Val Ala Asp Gln Gln Tyr Thr Ile Thr Gln Pro Tyr 
1               5                   10                  15      


Trp Ala Thr Asp Ala Thr 
            20          


<210>  18
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  18

Gln His Leu Ser Val Ala Asp Gln Gln Tyr Thr Ile Thr Gln Pro Tyr 
1               5                   10                  15      


Trp Ala Thr Asp Ala Thr 
            20          


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  19

Gln His Leu Ser Thr Ala Asp Gln Gln Tyr Val Thr Thr Gln Pro Tyr 
1               5                   10                  15      


Trp Ala Thr Asp Ala Thr 
            20          


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM2 Variant

<400>  20

Gln His Gln Ser Thr Ala Asp Gln Gln Tyr Thr Thr Thr Gln Pro Tyr 
1               5                   10                  15      


Trp Ala Thr Asp Ala Thr 
            20          


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC2

<400>  21

Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys 
1               5                   10      


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  22

Ala Val His Val Thr Tyr Thr Val Asn Gln Tyr Ser Ser Val Gln Ile 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  23

Ala Val His Thr Thr Tyr Thr Val Asn Gln Tyr Ser Ser Val Gln Ile 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence;

<220>
<223>  CXCR4 TM3 Variant

<400>  24

Ala Val His Thr Thr Tyr Thr Val Asn Gln Tyr Ser Ser Val Gln Thr 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  25

Ala Thr His Thr Thr Tyr Thr Val Asn Gln Tyr Ser Ser Val Gln Thr 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  26

Ala Thr His Thr Ile Tyr Thr Thr Asn Gln Tyr Ser Ser Val Gln Thr 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  27

Ala Val His Thr Thr Tyr Thr Thr Asn Gln Tyr Ser Ser Val Gln Thr 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  28

Ala Thr His Thr Thr Tyr Thr Thr Asn Gln Tyr Ser Ser Val Gln Thr 
1               5                   10                  15      


Gln Ala Phe Thr 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM3 Variant

<400>  29

Ala Thr His Thr Thr Tyr Thr Thr Asn Gln Tyr Ser Ser Thr Gln Thr 
1               5                   10                  15      


Gln Ala Tyr Thr 
            20  


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IC2

<400>  30

Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser Gln Arg 
1               5                   10                  15      


Pro Arg Lys Leu Leu Ala Glu Lys 
            20                  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  31

Val Thr Tyr Thr Gly Val Trp Thr Pro Ala Gln Gln Gln Thr Ile Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  32

Thr Thr Tyr Thr Gly Thr Trp Ile Pro Ala Gln Gln Gln Thr Ile Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  33

Thr Thr Tyr Thr Gly Thr Trp Thr Pro Ala Gln Gln Gln Thr Ile Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  34

Thr Thr Tyr Thr Gly Thr Trp Thr Pro Ala Gln Gln Gln Thr Ile Pro 
1               5                   10                  15      


Asp Phe Ile Tyr 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  35

Thr Thr Tyr Val Gly Thr Trp Thr Pro Ala Gln Gln Gln Thr Thr Pro 
1               5                   10                  15      


Asp Tyr Ile Phe 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  36

Thr Thr Tyr Val Gly Thr Trp Thr Pro Ala Gln Gln Gln Thr Thr Pro 
1               5                   10                  15      


Asp Phe Ile Tyr 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  37

Thr Thr Tyr Thr Gly Val Trp Thr Pro Ala Gln Gln Gln Thr Thr Pro 
1               5                   10                  15      


Asp Tyr Thr Phe 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM4 Variant

<400>  38

Thr Thr Tyr Thr Gly Thr Trp Thr Pro Ala Gln Gln Gln Thr Thr Pro 
1               5                   10                  15      


Asp Tyr Thr Tyr 
            20  


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC3

<400>  39

Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr 
1               5                   10                  15      


Pro Asn Asp Leu Trp 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  40

Val Val Val Phe Gln Phe Gln His Thr Met Val Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  41

Val Val Val Phe Gln Phe Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  42

Val Val Val Phe Gln Tyr Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  43

Val Val Val Tyr Gln Tyr Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  44

Thr Val Val Phe Gln Tyr Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  45

Val Val Thr Phe Gln Tyr Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  46
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  46

Thr Val Val Tyr Gln Tyr Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM5 Variant

<400>  47

Thr Thr Thr Tyr Gln Tyr Gln His Thr Met Thr Gly Gln Thr Gln Pro 
1               5                   10                  15      


Gly Thr Thr Thr Gln 
            20      


<210>  48
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IC3

<400>  48

Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His 
1               5                   10                  15      


Gln Lys Arg Lys Ala Leu Lys Thr Thr 
            20                  25  


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  49

Val Thr Gln Ile Gln Ala Phe Phe Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  50

Val Ile Gln Ile Gln Ala Tyr Phe Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  51

Val Ile Gln Ile Gln Ala Tyr Tyr Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  52

Val Ile Gln Thr Gln Ala Phe Tyr Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  53

Val Ile Gln Thr Gln Ala Tyr Phe Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  54

Val Thr Gln Ile Gln Ala Phe Tyr Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  55

Val Ile Gln Thr Gln Ala Tyr Tyr Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM6 Variant

<400>  56

Thr Thr Gln Thr Gln Ala Tyr Tyr Ala Cys Trp Gln Pro Tyr Tyr Thr 
1               5                   10                  15      


Gly Thr Ser Thr 
            20  


<210>  57
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC4

<400>  57

Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu 
1               5                   10                  15      


Asn Thr Val His Lys 
            20      


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  58

Trp Ile Ser Ile Thr Glu Ala Gln Ala Phe Phe His Cys Cys Leu Asn 
1               5                   10                  15      


Pro Ile Gln Tyr 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  59

Trp Ile Ser Ile Thr Glu Ala Gln Ala Phe Tyr His Cys Cys Leu Asn 
1               5                   10                  15      


Pro Ile Gln Tyr 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  60

Trp Ile Ser Ile Thr Glu Ala Gln Ala Tyr Phe His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Thr Leu Tyr 
            20  


<210>  61
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  61

Trp Ile Ser Thr Thr Glu Ala Leu Ala Phe Tyr His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Thr Gln Tyr 
            20  


<210>  62
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  62

Trp Ile Ser Thr Thr Glu Ala Leu Ala Tyr Phe His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Thr Gln Tyr 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  63

Trp Ile Ser Ile Thr Glu Ala Leu Ala Tyr Tyr His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Thr Gln Tyr 
            20  


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  64

Trp Ile Ser Thr Thr Glu Ala Leu Ala Tyr Tyr His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Thr Gln Tyr 
            20  


<210>  65
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IC4

<400>  65

Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr 
1               5                   10                  15      


Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg 
            20                  25                  30          


Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His 
        35                  40                  45              


Ser Ser 
    50  


<210>  66
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  67
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Varient

<400>  67

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Thr Gly 
        35                  40                  45              


Asn Gln Gln Thr Thr Tyr Ala Gln Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Thr Tyr Gln Gln Asn Gln Ala Gln Ser Asp Gln Gln Tyr 
65                  70                  75                  80  


Thr Ala Thr Gln Pro Tyr Trp Thr His Tyr Gln Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Tyr Tyr Tyr Thr Gly 
            100                 105                 110         


Tyr Tyr Gly Ser Thr Tyr Tyr Thr Thr Thr Thr Ser Thr Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Thr Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Thr Gln Thr 
145                 150                 155                 160 


Ala Ala Pro Gln Tyr Met Tyr Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Tyr Gln Gly Tyr Gln Gln Pro Gln Gln Thr Met Ser 
        195                 200                 205             


Tyr Cys Tyr Tyr Arg Thr Thr Gln Thr Gln Tyr Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Gln Thr Gln Gln Thr Thr Thr Thr Tyr 
225                 230                 235                 240 


Tyr Gln Tyr Trp Thr Pro Tyr Asn Thr Met Thr Tyr Gln Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Gln Ser Thr Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Gln 
        275                 280                 285             


Asn Pro Gln Thr Tyr Ala Tyr Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  68
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Varient

<400>  68

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr 
            20                  25                  30      


<210>  69
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  69

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Phe Ala Thr Gly Gln Val 
1               5                   10                  15      


Gly Asn Gln Gln Val Val Phe Ala Leu Thr Asn Ser 
            20                  25              


<210>  70
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  70

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Val 
1               5                   10                  15      


Gly Asn Gln Gln Val Val Phe Ala Leu Thr Asn Ser 
            20                  25              


<210>  71
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  71

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Val 
1               5                   10                  15      


Gly Asn Gln Gln Val Val Phe Ala Gln Thr Asn Ser 
            20                  25              


<210>  72
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  72

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Thr 
1               5                   10                  15      


Gly Asn Leu Gln Val Thr Phe Ala Gln Thr Asn Ser 
            20                  25              


<210>  73
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  73

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Thr 
1               5                   10                  15      


Gly Asn Gln Leu Val Thr Phe Ala Gln Thr Asn Ser 
            20                  25              


<210>  74
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  74

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Thr 
1               5                   10                  15      


Gly Asn Gln Gln Val Val Phe Ala Gln Thr Asn Ser 
            20                  25              


<210>  75
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  75

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Thr 
1               5                   10                  15      


Gly Asn Leu Gln Val Thr Tyr Ala Gln Thr Asn Ser 
            20                  25              


<210>  76
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM1 Variant

<400>  76

Thr Tyr Gln Ser Thr Tyr Tyr Ser Thr Thr Tyr Ala Thr Gly Gln Thr 
1               5                   10                  15      


Gly Asn Gln Gln Thr Thr Tyr Ala Gln Thr Asn Ser 
            20                  25              


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  77

Lys Lys Pro Lys Ser Val Thr Asp Ile Tyr 
1               5                   10  


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  78

Leu Leu Asn Gln Ala Gln Ser Asp Gln Leu Phe Val Ala Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  79
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  79

Leu Leu Asn Gln Ala Gln Ser Asp Gln Gln Phe Val Ala Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  80
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  80

Gln Gln Asn Leu Ala Gln Ser Asp Gln Gln Phe Val Ala Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  81
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  81

Leu Gln Asn Leu Ala Gln Ser Asp Gln Gln Tyr Thr Ala Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  82
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  82

Gln Leu Asn Leu Ala Gln Ser Asp Gln Gln Tyr Thr Ala Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  83
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  83

Leu Leu Asn Gln Ala Gln Ser Asp Gln Gln Phe Thr Ala Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  84
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  84

Gln Gln Asn Leu Ala Gln Ser Asp Gln Gln Phe Thr Ala Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  85
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM2 Variant

<400>  85

Gln Gln Asn Gln Ala Gln Ser Asp Gln Gln Tyr Thr Ala Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  86

Leu Ile Asn Glu Lys Gly Leu His Asn Ala Met Cys Lys 
1               5                   10              


<210>  87
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM3 Variant

<400>  87

Tyr Thr Thr Ala Tyr Tyr Tyr Thr Gly Tyr Tyr Gly Ser Thr Tyr Tyr 
1               5                   10                  15      


Thr Thr Thr Thr Ser Thr 
            20          


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  88

Asp Arg Tyr Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg 
1               5                   10                  15      


Thr 
    


<210>  89
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  89

Val Gln His Gly Thr Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Val Ala Ala Pro Gln Phe Met Phe 
            20                  25  


<210>  90
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  90

Val Gln His Gly Val Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Phe Met Phe 
            20                  25  


<210>  91
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  91

Val Gln His Gly Thr Thr Thr Ser Gln Gly Val Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Phe Met Tyr 
            20                  25  


<210>  92
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  92

Val Gln His Gly Thr Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Ile 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Phe Met Tyr 
            20                  25  


<210>  93
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  93

Val Gln His Gly Thr Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Phe Met Phe 
            20                  25  


<210>  94
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  94

Val Gln His Gly Thr Thr Ile Ser Gln Gly Thr Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Tyr Met Phe 
            20                  25  


<210>  95
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  95

Val Gln His Gly Thr Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Phe Met Tyr 
            20                  25  


<210>  96
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM4 Variant

<400>  96

Thr Gln His Gly Thr Thr Thr Ser Gln Gly Thr Trp Ala Ala Ala Thr 
1               5                   10                  15      


Gln Thr Ala Ala Pro Gln Tyr Met Tyr 
            20                  25  


<210>  97
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  97

Thr Lys Gln Lys Glu Asn Glu Cys Leu Gly Asp Tyr Pro Glu Val Leu 
1               5                   10                  15      


Gln Glu Ile Trp Pro Val Leu Arg Asn Val Glu Thr 
            20                  25              


<210>  98
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  98

Asn Phe Leu Gly Phe Gln Gln Pro Gln Gln Ile Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Phe Arg Ile Thr 
            20  


<210>  99
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  99

Asn Phe Gln Gly Phe Leu Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Phe Arg Ile Thr 
            20  


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  100

Asn Phe Gln Gly Phe Leu Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Phe Arg Thr Thr 
            20  


<210>  101
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  101

Asn Phe Gln Gly Phe Gln Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Tyr Arg Ile Thr 
            20  


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  102

Asn Phe Gln Gly Phe Leu Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Tyr Arg Thr Thr 
            20  


<210>  103
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  103

Asn Phe Gln Gly Tyr Leu Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Phe Arg Thr Thr 
            20  


<210>  104
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  104

Asn Tyr Gln Gly Phe Gln Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Phe Arg Thr Thr 
            20  


<210>  105
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM5 Variant

<400>  105

Asn Tyr Gln Gly Tyr Gln Gln Pro Gln Gln Thr Met Ser Tyr Cys Tyr 
1               5                   10                  15      


Tyr Arg Thr Thr 
            20  


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  106

Gln Thr Leu Phe Ser Cys Lys Asn His Lys Lys Ala Lys Ala Ile Lys 
1               5                   10                  15      


<210>  107
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  107

Leu Ile Gln Gln Thr Thr Thr Thr Phe Tyr Gln Phe Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Phe Gln Glu Thr Leu 
            20                  25  


<210>  108
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  108

Leu Ile Gln Gln Thr Thr Thr Thr Phe Tyr Gln Tyr Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Val Met Thr Phe Gln Glu Thr Gln 
            20                  25  


<210>  109
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  109

Leu Ile Gln Gln Thr Thr Thr Thr Tyr Tyr Gln Phe Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Phe Gln Glu Thr Gln 
            20                  25  


<210>  110
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  110

Gln Ile Gln Gln Thr Thr Thr Thr Phe Tyr Gln Tyr Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Phe Gln Glu Thr Gln 
            20                  25  


<210>  111
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  111

Leu Thr Gln Gln Thr Thr Thr Thr Tyr Tyr Gln Phe Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Phe Gln Glu Thr Gln 
            20                  25  


<210>  112
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  112

Gln Ile Gln Gln Thr Thr Thr Thr Phe Phe Gln Tyr Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Tyr Gln Glu Thr Gln 
            20                  25  


<210>  113
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  113

Gln Ile Gln Gln Thr Thr Thr Thr Phe Tyr Gln Tyr Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Tyr Gln Glu Thr Gln 
            20                  25  


<210>  114
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM6 Variant

<400>  114

Gln Thr Gln Gln Thr Thr Thr Thr Tyr Tyr Gln Tyr Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Met Thr Tyr Gln Glu Thr Gln 
            20                  25  


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  115

Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
1               5                   10                  15      


Leu 
    


<210>  116
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  116

Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Ile Tyr Ala Phe Ala Gly 
            20                  


<210>  117
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  117

Ala Gln Ser Val Thr Glu Thr Thr Ala Phe Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Leu Ile Tyr Ala Phe Ala Gly 
            20                  


<210>  118
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  118

Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Thr Tyr Ala Tyr Ala Gly 
            20                  


<210>  119
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  119

Ala Gln Ser Val Thr Glu Thr Thr Ala Phe Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Ile Tyr Ala Tyr Ala Gly 
            20                  


<210>  120
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  120

Ala Leu Ser Val Thr Glu Thr Thr Ala Phe Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Thr Tyr Ala Tyr Ala Gly 
            20                  


<210>  121
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  121

Ala Leu Ser Thr Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Ile Tyr Ala Phe Ala Gly 
            20                  


<210>  122
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  122

Ala Leu Ser Val Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Thr Tyr Ala Tyr Ala Gly 
            20                  


<210>  123
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 TM7 Variant

<400>  123

Ala Gln Ser Thr Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Thr Tyr Ala Tyr Ala Gly 
            20                  


<210>  124
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX3CR1 Variant

<400>  124

Glu Lys Phe Arg Arg Tyr Leu Tyr His Leu Tyr Gly Lys Cys Leu Ala 
1               5                   10                  15      


Val Leu Cys Gly Arg Ser Val His Val Asp Phe Ser Ser Ser Glu Ser 
            20                  25                  30          


Gln Arg Ser Arg His Gly Ser Val Leu Ser Ser Asn Phe Thr Tyr His 
        35                  40                  45              


Thr Ser Asp Gly Asp Ala Leu Leu Leu Leu 
    50                  55              


<210>  125
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Arg 
1               5                   10                  15      


Ser Glu Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr 
            20                  25                  30          


Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg 
        35                  40                  45              


Ala Leu Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr 
    50                  55                  60                  


Val Gly Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr 
65                  70                  75                  80  


Arg Arg Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile 
                85                  90                  95      


Ser Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val 
            100                 105                 110         


Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser 
        115                 120                 125             


Gly Phe Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu 
    130                 135                 140                 


Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu 
145                 150                 155                 160 


Arg Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp 
                165                 170                 175     


Gly Leu Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr 
            180                 185                 190         


Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp 
        195                 200                 205             


Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe 
    210                 215                 220                 


Cys Leu Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile 
225                 230                 235                 240 


Ile Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile 
                245                 250                 255     


Arg Leu Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro 
            260                 265                 270         


Tyr Asn Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly 
        275                 280                 285             


Asn Asp Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr 
    290                 295                 300                 


Glu Val Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala 
305                 310                 315                 320 


Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg 
                325                 330                 335     


His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu 
            340                 345                 350         


Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu 
        355                 360                 365             


Leu Ser Ile Val Phe 
    370             


<210>  126
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  126

Met Pro Phe Gly Ile Arg Met Leu Leu Arg Ala His Lys Pro Gly Arg 
1               5                   10                  15      


Ser Glu Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr 
            20                  25                  30          


Ser Tyr Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg 
        35                  40                  45              


Ala Leu Met Ala Gln Phe Val Pro Pro Gln Tyr Ser Gln Thr Tyr Thr 
    50                  55                  60                  


Thr Gly Gln Gln Gly Asn Thr Thr Thr Thr Met Thr Gln Thr Lys Tyr 
65                  70                  75                  80  


Arg Arg Leu Arg Ile Met Thr Asn Thr Tyr Gln Gln Asn Gln Ala Thr 
                85                  90                  95      


Ser Asp Gln Gln Tyr Gln Thr Thr Gln Pro Tyr Trp Thr His Tyr Val 
            100                 105                 110         


Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser 
        115                 120                 125             


Gly Phe Tyr His Thr Gly Leu Tyr Ser Glu Thr Tyr Tyr Thr Thr Gln 
    130                 135                 140                 


Gln Thr Thr Asp Arg Tyr Gln Ala Thr Thr His Ala Thr Tyr Ala Gln 
145                 150                 155                 160 


Arg Ala Arg Thr Val Thr Phe Gly Thr Thr Thr Ser Thr Thr Thr Trp 
                165                 170                 175     


Gly Gln Ala Thr Gln Ala Ala Gln Pro Glu Tyr Thr Tyr Tyr Glu Thr 
            180                 185                 190         


Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp 
        195                 200                 205             


Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Thr Tyr 
    210                 215                 220                 


Cys Gln Thr Gln Pro Gln Gln Thr Met Ala Thr Cys Tyr Thr Gly Thr 
225                 230                 235                 240 


Thr Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile 
                245                 250                 255     


Arg Gln Thr Tyr Thr Thr Met Ala Thr Tyr Tyr Thr Tyr Trp Thr Pro 
            260                 265                 270         


Tyr Asn Thr Ala Thr Gln Gln Ser Ser Tyr Gln Ser Ile Leu Phe Gly 
        275                 280                 285             


Asn Asp Cys Glu Arg Ser Lys His Leu Asp Gln Thr Met Gln Thr Thr 
    290                 295                 300                 


Glu Thr Thr Ala Tyr Ser His Cys Cys Met Asn Pro Thr Thr Tyr Ala 
305                 310                 315                 320 


Tyr Thr Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg 
                325                 330                 335     


His Leu Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu 
            340                 345                 350         


Lys Leu Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu 
        355                 360                 365             


Leu Ser Ile Val Phe 
    370             


<210>  127
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  127

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala 
        


<210>  128
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  128

Gln Phe Val Pro Pro Gln Tyr Ser Gln Thr Phe Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Val Thr Val Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  129
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  129

Gln Phe Val Pro Pro Gln Tyr Ser Gln Thr Phe Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Thr Thr Val Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  130
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  130

Gln Phe Val Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Thr Thr Val Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  131
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  131

Gln Phe Thr Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Val Thr Thr Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  132
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  132

Gln Phe Thr Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Thr Val Thr Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  133
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  133

Gln Phe Thr Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Thr Thr Val Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  134
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  134

Gln Phe Thr Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Thr Thr Thr Thr Met Thr Gln Ile Lys Tyr 
            20                  25              


<210>  135
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM1 Variant

<400>  135

Gln Tyr Thr Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly Gln Gln 
1               5                   10                  15      


Gly Asn Thr Thr Thr Thr Met Thr Gln Thr Lys Tyr 
            20                  25              


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  136

Arg Arg Leu Arg Ile Met Thr Asn Ile Tyr 
1               5                   10  


<210>  137
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM2 Variant

<400>  137

Leu Leu Asn Gln Ala Thr Ser Asp Gln Gln Phe Gln Val Thr Gln Pro 
1               5                   10                  15      


Phe Trp Ile His Tyr 
            20      


<210>  138
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM2 Variant

<400>  138

Leu Gln Asn Gln Ala Ile Ser Asp Gln Leu Phe Gln Thr Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  139
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM2 Variant

<400>  139

Gln Gln Asn Leu Ala Ile Ser Asp Gln Gln Phe Gln Thr Thr Gln Pro 
1               5                   10                  15      


Phe Trp Thr His Tyr 
            20      


<210>  140
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM2 Variant

<400>  140

Gln Leu Asn Gln Ala Ile Ser Asp Gln Gln Phe Gln Thr Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  141
<211>  21
<212>  PRT
<213>  Artificial Sequence;CCR3 TM2 Variant

<220>
<223>  CCR3 TM2 Variant

<400>  141

Gln Gln Asn Leu Ala Ile Ser Asp Gln Gln Tyr Gln Val Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  142
<211>  21
<212>  PRT
<213>  Artificial Sequence;CCR3 TM2 Variant

<220>
<223>  CCR3 TM2 Variant

<400>  142

Leu Gln Asn Gln Ala Thr Ser Asp Gln Leu Phe Gln Thr Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  143
<211>  21
<212>  PRT
<213>  Artificial Sequence;CCR3 TM2 Variant

<220>
<223>  CCR3 TM2 Variant

<400>  143

Gln Gln Asn Gln Ala Ile Ser Asp Gln Gln Tyr Gln Val Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  144
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM2 Variant

<400>  144

Gln Gln Asn Gln Ala Thr Ser Asp Gln Gln Tyr Gln Thr Thr Gln Pro 
1               5                   10                  15      


Tyr Trp Thr His Tyr 
            20      


<210>  145
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  145

Val Arg Gly His Asn Trp Val Phe Gly His Gly Met Cys Lys 
1               5                   10                  


<210>  146
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  146

Leu Gln Ser Gly Phe Tyr His Thr Gly Gln Tyr Ser Glu Thr Phe Phe 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  147
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  147

Gln Leu Ser Gly Phe Tyr His Thr Gly Gln Tyr Ser Glu Thr Phe Phe 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  148
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  148

Gln Leu Ser Gly Phe Tyr His Thr Gly Gln Tyr Ser Glu Thr Phe Tyr 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  149
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  149

Gln Leu Ser Gly Phe Tyr His Thr Gly Gln Tyr Ser Glu Thr Tyr Phe 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  150
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  150

Gln Leu Ser Gly Tyr Tyr His Thr Gly Gln Tyr Ser Glu Thr Phe Phe 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  151
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  151

Gln Gln Ser Gly Phe Tyr His Thr Gly Gln Tyr Ser Glu Thr Phe Phe 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  152
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  152

Gln Gln Ser Gly Phe Tyr His Thr Gly Gln Tyr Ser Glu Thr Phe Tyr 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  153
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM3 Variant

<400>  153

Gln Gln Ser Gly Tyr Tyr His Thr Gly Gln Tyr Ser Glu Thr Tyr Tyr 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  154

Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala Arg 
1               5                   10                  15      


Thr 
    


<210>  155
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  155

Thr Thr Phe Gly Thr Thr Thr Ser Thr Val Thr Trp Gly Gln Ala Val 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Ile Phe 
            20                  25  


<210>  156
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  156

Thr Thr Phe Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Val 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Ile Phe 
            20                  25  


<210>  157
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  157

Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Val 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Ile Phe 
            20                  25  


<210>  158
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  158

Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Val 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Thr Phe 
            20                  25  


<210>  159
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  159

Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Thr 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Ile Phe 
            20                  25  


<210>  160
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  160

Thr Thr Phe Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Thr 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Ile Tyr 
            20                  25  


<210>  161
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  161

Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Thr 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Phe Ile Tyr 
            20                  25  


<210>  162
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM4 Variant

<400>  162

Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Gly Gln Ala Thr 
1               5                   10                  15      


Gln Ala Ala Gln Pro Glu Tyr Thr Tyr 
            20                  25  


<210>  163
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  163

Tyr Glu Thr Glu Glu Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr 
1               5                   10                  15      


Pro Glu Asp Thr Val Tyr Ser Trp Arg His Phe His Thr Leu Arg Met 
            20                  25                  30          


<210>  164
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  164

Thr Ile Phe Cys Gln Val Gln Pro Gln Gln Thr Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Thr 
            20  


<210>  165
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  165

Thr Ile Phe Cys Gln Thr Gln Pro Gln Gln Val Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Thr 
            20  


<210>  166
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  166

Thr Ile Phe Cys Gln Thr Gln Pro Gln Gln Thr Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Ile Thr 
            20  


<210>  167
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  167

Thr Ile Phe Cys Gln Thr Gln Pro Gln Gln Thr Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Ile 
            20  


<210>  168
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  168

Thr Thr Phe Cys Gln Val Gln Pro Gln Gln Val Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Thr 
            20  


<210>  169
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  169

Thr Ile Tyr Cys Gln Val Gln Pro Gln Gln Val Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Thr 
            20  


<210>  170
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  170

Thr Ile Phe Cys Gln Thr Gln Pro Gln Gln Thr Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Thr 
            20  


<210>  171
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM5 Variant

<400>  171

Thr Thr Tyr Cys Gln Thr Gln Pro Gln Gln Thr Met Ala Thr Cys Tyr 
1               5                   10                  15      


Thr Gly Thr Thr 
            20  


<210>  172
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Variant

<400>  172

Lys Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg 
1               5                   10                  15      


<210>  173
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM6 Variant

<400>  173

Gln Thr Tyr Thr Thr Met Ala Thr Tyr Tyr Thr Tyr Trp Thr Pro Tyr 
1               5                   10                  15      


Asn Thr Ala Thr Gln Gln Ser Ser Tyr 
            20                  25  


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM6 Variant

<400>  174

Gln Ser Ile Leu Phe Gly Asn Asp Cys Glu Arg Ser Lys His Leu Asp 
1               5                   10                  15      


Leu 
    


<210>  175
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  175

Val Met Gln Val Thr Glu Val Thr Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Val Thr Tyr Ala Phe Thr Gly 
            20                  


<210>  176
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  176

Val Met Gln Val Thr Glu Val Thr Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Tyr Val Gly 
            20                  


<210>  177
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  177

Val Met Leu Thr Thr Glu Val Thr Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Phe Thr Gly 
            20                  


<210>  178
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  178

Val Met Gln Val Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Val Thr Tyr Ala Tyr Thr Gly 
            20                  


<210>  179
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  179

Thr Met Gln Val Thr Glu Thr Ile Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Phe Thr Gly 
            20                  


<210>  180
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  180

Thr Met Gln Val Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Phe Val Gly 
            20                  


<210>  181
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  181

Val Met Gln Thr Thr Glu Thr Ile Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Tyr Thr Gly 
            20                  


<210>  182
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 TM7 Variant

<400>  182

Thr Met Gln Thr Thr Glu Thr Thr Ala Tyr Ser His Cys Cys Met Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Tyr Thr Gly 
            20                  


<210>  183
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR3 Varient

<400>  183

Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu Leu 
1               5                   10                  15      


Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu Glu 
            20                  25                  30          


Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser Ile 
        35                  40                  45              


Val Phe 
    50  


<210>  184
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  185
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  185

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Tyr Gly Tyr Thr Gly Asn 
        35                  40                  45              


Met Gln Thr Thr Gln Thr Gln Thr Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Thr Tyr Gln Gln Asn Gln Ala Thr Ser Asp Gln Tyr Tyr Gln 
65                  70                  75                  80  


Gln Thr Thr Pro Tyr Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Gln Gln Thr Gly Gln Tyr Tyr Thr Gly Tyr 
            100                 105                 110         


Tyr Ser Gly Thr Tyr Tyr Thr Thr Gln Gln Thr Thr Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Tyr 
    130                 135                 140                 


Gly Thr Thr Thr Ser Thr Thr Thr Trp Thr Thr Ala Thr Tyr Ala Ser 
145                 150                 155                 160 


Gln Pro Gly Thr Thr Tyr Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Thr Thr Thr Gln Gly Gln Thr Gln Pro Gln Gln 
        195                 200                 205             


Thr Met Thr Thr Cys Tyr Ser Gly Thr Gln Lys Thr Gln Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Gln Thr Tyr Thr Thr 
225                 230                 235                 240 


Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr Asn Thr Thr Gln Gln 
                245                 250                 255     


Gln Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Thr Asn Pro Thr Thr Tyr Ala Tyr Thr Gly Glu Lys Tyr 
    290                 295                 300                 


Arg Asn Tyr Gln Gln Thr Tyr Tyr Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  186
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  186

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala 
            20                  25                  30  


<210>  187
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  187

Arg Leu Gln Pro Pro Gln Tyr Ser Gln Thr Phe Thr Phe Gly Phe Thr 
1               5                   10                  15      


Gly Asn Met Gln Val Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  188
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  188

Arg Leu Gln Pro Pro Gln Tyr Ser Gln Thr Phe Thr Phe Gly Tyr Thr 
1               5                   10                  15      


Gly Asn Met Gln Val Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  189
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  189

Arg Gln Gln Pro Pro Gln Tyr Ser Gln Thr Phe Thr Phe Gly Phe Thr 
1               5                   10                  15      


Gly Asn Met Gln Thr Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  190
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  190

Arg Gln Gln Pro Pro Gln Tyr Ser Gln Thr Phe Thr Tyr Gly Phe Thr 
1               5                   10                  15      


Gly Asn Met Gln Thr Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  191
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  191

Arg Gln Gln Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Phe Gly Phe Thr 
1               5                   10                  15      


Gly Asn Met Gln Thr Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  192
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  192

Arg Gln Gln Pro Pro Gln Tyr Ser Gln Thr Phe Thr Phe Gly Tyr Thr 
1               5                   10                  15      


Gly Asn Met Gln Thr Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  193
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  193

Arg Gln Gln Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Phe Gly Tyr Thr 
1               5                   10                  15      


Gly Asn Met Gln Thr Thr Gln Thr Gln Ile Asn Cys 
            20                  25              


<210>  194
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM1 Varient

<400>  194

Arg Gln Gln Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Tyr Gly Tyr Thr 
1               5                   10                  15      


Gly Asn Met Gln Thr Thr Gln Thr Gln Thr Asn Cys 
            20                  25              


<210>  195
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  195

Lys Arg Leu Lys Ser Met Thr Asp Ile Tyr 
1               5                   10  


<210>  196
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  196

Leu Gln Asn Gln Ala Ile Ser Asp Gln Phe Phe Gln Gln Thr Val Pro 
1               5                   10                  15      


Phe Trp Ala His Tyr 
            20      


<210>  197
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  197

Leu Gln Asn Gln Ala Ile Ser Asp Gln Phe Phe Gln Gln Thr Thr Pro 
1               5                   10                  15      


Phe Trp Ala His Tyr 
            20      


<210>  198
<211>  21
<212>  PRT
<213>  Artificial Sequence;CCR5 TM2 Varient

<220>
<223>  CCR5 TM2 Varient

<400>  198

Leu Gln Asn Gln Ala Ile Ser Asp Gln Phe Phe Gln Gln Thr Thr Pro 
1               5                   10                  15      


Tyr Trp Ala His Tyr 
            20      


<210>  199
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  199

Leu Gln Asn Gln Ala Ile Ser Asp Gln Phe Tyr Gln Gln Thr Thr Pro 
1               5                   10                  15      


Tyr Trp Ala His Tyr 
            20      


<210>  200
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  200

Leu Gln Asn Gln Ala Ile Ser Asp Gln Tyr Phe Gln Gln Thr Thr Pro 
1               5                   10                  15      


Tyr Trp Ala His Tyr 
            20      


<210>  201
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  201

Leu Gln Asn Gln Ala Thr Ser Asp Gln Phe Phe Gln Gln Thr Thr Pro 
1               5                   10                  15      


Tyr Trp Ala His Tyr 
            20      


<210>  202
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  202

Leu Gln Asn Gln Ala Ile Ser Asp Gln Tyr Tyr Gln Gln Thr Thr Pro 
1               5                   10                  15      


Tyr Trp Ala His Tyr 
            20      


<210>  203
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM2 Varient

<400>  203

Gln Gln Asn Gln Ala Thr Ser Asp Gln Tyr Tyr Gln Gln Thr Thr Pro 
1               5                   10                  15      


Tyr Trp Ala His Tyr 
            20      


<210>  204
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  204

Ala Ala Ala Gln Trp Asp Phe Gly Asn Thr Met Cys Gln 
1               5                   10              


<210>  205
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM3 Varient

<400>  205

Gln Gln Thr Gly Gln Tyr Phe Thr Gly Tyr Tyr Ser Gly Thr Tyr Tyr 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  206
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM3 Varient

<400>  206

Gln Gln Thr Gly Gln Tyr Tyr Thr Gly Tyr Tyr Ser Gly Thr Tyr Tyr 
1               5                   10                  15      


Thr Thr Gln Gln Thr Thr 
            20          


<210>  207
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  207

Asp Arg Tyr Leu Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg 
1               5                   10                  15      


Thr 
    


<210>  208
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM4 Varient

<400>  208

Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Thr Thr Ala Thr 
1               5                   10                  15      


Tyr Ala Ser Gln Pro Gly Thr Thr Tyr 
            20                  25  


<210>  209
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  209

Thr Arg Ser Gln Lys Glu Gly Leu His Tyr Thr Cys Ser Ser His Phe 
1               5                   10                  15      


Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn Phe Gln Thr Leu Lys Ile 
            20                  25                  30          


<210>  210
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  210

Val Ile Gln Gly Gln Val Gln Pro Gln Gln Val Met Val Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Ile Gln 
            20  


<210>  211
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  211

Val Ile Gln Gly Gln Val Gln Pro Gln Gln Val Met Thr Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Ile Gln 
            20  


<210>  212
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  212

Val Ile Gln Gly Gln Val Gln Pro Gln Gln Thr Met Thr Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Ile Gln 
            20  


<210>  213
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  213

Thr Gln Gly Gln Val Gln Pro Gln Gln Thr Met Val Thr Cys Tyr Ser 
1               5                   10                  15      


Gly Thr Gln 
            


<210>  214
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  214

Thr Ile Gln Gly Gln Val Gln Pro Gln Gln Val Met Thr Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Thr Gln 
            20  


<210>  215
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  215

Thr Ile Gln Gly Gln Val Gln Pro Gln Gln Thr Met Val Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Thr Gln 
            20  


<210>  216
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  216

Thr Thr Gln Gly Gln Val Gln Pro Gln Gln Val Met Thr Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Thr Gln 
            20  


<210>  217
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM5 Varient

<400>  217

Thr Thr Gln Gly Gln Thr Gln Pro Gln Gln Thr Met Thr Thr Cys Tyr 
1               5                   10                  15      


Ser Gly Thr Gln 
            20  


<210>  218
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  218

Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg Ala Val 
1               5                   10                  15      


Arg 
    


<210>  219
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  219

Gln Thr Phe Thr Thr Met Thr Thr Tyr Tyr Gln Phe Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Ile Val Gln Gln Leu Asn Thr Phe 
            20                  25  


<210>  220
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  220

Gln Thr Phe Thr Thr Met Thr Thr Tyr Tyr Gln Phe Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Val Gln Gln Leu Asn Thr Phe 
            20                  25  


<210>  221
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  221

Gln Thr Phe Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Val Gln Gln Leu Asn Thr Phe 
            20                  25  


<210>  222
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  222

Gln Thr Phe Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Val Gln Gln Gln Asn Thr Phe 
            20                  25  


<210>  223
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  223

Gln Thr Tyr Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Val Gln Gln Leu Asn Thr Phe 
            20                  25  


<210>  224
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  224

Gln Thr Phe Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Thr Gln Gln Leu Asn Thr Phe 
            20                  25  


<210>  225
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  225

Gln Thr Tyr Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Val Gln Gln Gln Asn Thr Phe 
            20                  25  


<210>  226
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  226

Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser Asn Arg Leu Asp 
1               5                   10                  15      


Gln 
    


<210>  227
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  227

Ala Met Gln Val Thr Glu Thr Gln Gly Met Thr His Cys Cys Ile Asn 
1               5                   10                  15      


Pro Ile Ile Tyr Ala Phe Val Gly 
            20                  


<210>  228
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  228

Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Thr Asn 
1               5                   10                  15      


Pro Ile Ile Tyr Ala Phe Thr Gly 
            20                  


<210>  229
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  229

Ala Met Gln Val Thr Glu Thr Gln Gly Met Thr His Cys Cys Ile Asn 
1               5                   10                  15      


Pro Thr Ile Tyr Ala Tyr Val Gly 
            20                  


<210>  230
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  230

Ala Met Gln Thr Thr Glu Thr Gln Gly Met Thr His Cys Cys Ile Asn 
1               5                   10                  15      


Pro Ile Thr Tyr Ala Phe Thr Gly 
            20                  


<210>  231
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  231

Ala Met Gln Thr Thr Glu Thr Gln Gly Met Thr His Cys Cys Ile Asn 
1               5                   10                  15      


Pro Thr Ile Tyr Ala Phe Thr Gly 
            20                  


<210>  232
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  232

Ala Met Gln Val Thr Glu Thr Gln Gly Met Thr His Cys Cys Thr Asn 
1               5                   10                  15      


Pro Thr Ile Tyr Ala Tyr Val Gly 
            20                  


<210>  233
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  233

Ala Met Gln Thr Thr Glu Thr Gln Gly Met Thr His Cys Cys Ile Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Tyr Val Gly 
            20                  


<210>  234
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM7 Varient

<400>  234

Ala Met Gln Thr Thr Glu Thr Gln Gly Met Thr His Cys Cys Thr Asn 
1               5                   10                  15      


Pro Thr Thr Tyr Ala Tyr Thr Gly 
            20                  


<210>  235
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 Varient

<400>  235

Glu Lys Phe Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala 
1               5                   10                  15      


Lys Arg Phe Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu 
            20                  25                  30          


Arg Ala Ser Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser 
        35                  40                  45              


Val Gly Leu 
    50      


<210>  236
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  236

Ala Phe Leu Pro Ala Leu Tyr Ser Gln Gln Phe Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Val Ala Ala Thr Gln Leu Ser 
            20                  25          


<210>  237
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  237

Ala Phe Gln Pro Ala Leu Tyr Ser Gln Gln Phe Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Val Ala Ala Val Gln Gln Ser 
            20                  25          


<210>  238
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  238

Ala Phe Gln Pro Ala Gln Tyr Ser Gln Gln Phe Leu Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Val Ala Ala Thr Gln Gln Ser 
            20                  25          


<210>  239
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  239

Ala Tyr Gln Pro Ala Leu Tyr Ser Leu Gln Tyr Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Thr Ala Ala Val Gln Gln Ser 
            20                  25          


<210>  240
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  240

Ala Tyr Gln Pro Ala Leu Tyr Ser Gln Leu Phe Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Thr Ala Ala Thr Gln Gln Ser 
            20                  25          


<210>  241
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  241

Ala Phe Gln Pro Ala Leu Tyr Ser Leu Gln Tyr Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Thr Ala Ala Thr Gln Gln Ser 
            20                  25          


<210>  242
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  242

Ala Tyr Gln Pro Ala Gln Tyr Ser Leu Gln Tyr Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Thr Ala Ala Val Gln Gln Ser 
            20                  25          


<210>  243
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM1 Varient

<400>  243

Ala Tyr Gln Pro Ala Gln Tyr Ser Gln Gln Tyr Gln Gln Gly Gln Gln 
1               5                   10                  15      


Gly Asn Gly Ala Thr Ala Ala Thr Gln Gln Ser 
            20                  25          


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  244

Arg Arg Thr Ala Leu Ser Ser Thr Asp 
1               5                   


<210>  245
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  245

Thr Phe Leu Gln His Leu Ala Val Ala Asp Thr Gln Gln Val Gln Thr 
1               5                   10                  15      


Leu Pro Gln Trp Ala 
            20      


<210>  246
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  246

Thr Phe Leu Gln His Gln Ala Val Ala Asp Thr Gln Leu Val Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  247
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  247

Thr Phe Gln Gln His Leu Ala Val Ala Asp Thr Gln Gln Val Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  248
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  248

Thr Tyr Leu Gln His Gln Ala Val Ala Asp Thr Gln Gln Val Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  249
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  249

Thr Tyr Gln Leu His Gln Ala Val Ala Asp Thr Gln Gln Val Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  250
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  250

Thr Tyr Gln Gln His Leu Ala Val Ala Asp Thr Gln Gln Val Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  251
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  251

Thr Tyr Gln Gln His Gln Ala Val Ala Asp Thr Gln Gln Val Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  252
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM2 Varient

<400>  252

Thr Tyr Gln Gln His Gln Ala Thr Ala Asp Thr Gln Gln Thr Gln Thr 
1               5                   10                  15      


Gln Pro Gln Trp Ala 
            20      


<210>  253
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  253

Val Asp Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys 
1               5                   10                  15  


<210>  254
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  254

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Phe Tyr Ala Gly Ala Gln Gln 
1               5                   10                  15      


Gln Ala Cys Ile Ser Phe 
            20          


<210>  255
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  255

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Phe Tyr Ala Gly Ala Gln Leu 
1               5                   10                  15      


Gln Ala Cys Thr Ser Phe 
            20          


<210>  256
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  256

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Phe Tyr Ala Gly Ala Gln Gln 
1               5                   10                  15      


Leu Ala Cys Thr Ser Phe 
            20          


<210>  257
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  257

Thr Ala Gly Ala Gln Phe Asn Thr Asn Tyr Tyr Ala Gly Ala Gln Gln 
1               5                   10                  15      


Gln Ala Cys Ile Ser Phe 
            20          


<210>  258
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  258

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Tyr Tyr Ala Gly Ala Gln Gln 
1               5                   10                  15      


Gln Ala Cys Ile Ser Phe 
            20          


<210>  259
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  259

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Tyr Tyr Ala Gly Ala Gln Leu 
1               5                   10                  15      


Gln Ala Cys Thr Ser Phe 
            20          


<210>  260
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  260

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Tyr Tyr Ala Gly Ala Gln Gln 
1               5                   10                  15      


Leu Ala Cys Thr Ser Phe 
            20          


<210>  261
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM3 Varient

<400>  261

Thr Ala Gly Ala Gln Tyr Asn Thr Asn Tyr Tyr Ala Gly Ala Gln Gln 
1               5                   10                  15      


Gln Ala Cys Thr Ser Tyr 
            20          


<210>  262
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  262

Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg Arg Gly 
1               5                   10                  15      


Pro Pro Ala Arg Val Thr 
            20          


<210>  263
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  263

Leu Thr Cys Gln Ala Val Trp Gly Gln Cys Gln Gln Phe Ala Gln Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  264
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  264

Gln Thr Cys Gln Ala Val Trp Gly Gln Cys Gln Gln Phe Ala Gln Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  265
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  265

Gln Thr Cys Gln Ala Thr Trp Gly Gln Cys Gln Gln Phe Ala Gln Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  266
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  266

Gln Thr Cys Gln Ala Thr Trp Gly Gln Cys Gln Gln Tyr Ala Gln Pro 
1               5                   10                  15      


Asp Phe Ile Phe 
            20  


<210>  267
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  267

Gln Thr Cys Gln Ala Thr Trp Gly Gln Cys Gln Gln Phe Ala Gln Pro 
1               5                   10                  15      


Asp Phe Thr Phe 
            20  


<210>  268
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  268

Gln Thr Cys Gln Ala Thr Trp Gly Gln Cys Gln Gln Phe Ala Gln Pro 
1               5                   10                  15      


Asp Tyr Ile Phe 
            20  


<210>  269
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  269

Gln Thr Cys Gln Ala Thr Trp Gly Gln Cys Gln Gln Tyr Ala Gln Pro 
1               5                   10                  15      


Asp Tyr Ile Phe 
            20  


<210>  270
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM4 Varient

<400>  270

Gln Thr Cys Gln Ala Thr Trp Gly Gln Cys Gln Gln Tyr Ala Gln Pro 
1               5                   10                  15      


Asp Tyr Thr Tyr 
            20  


<210>  271
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  271

Leu Ser Ala His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr 
1               5                   10                  15      


Asn Phe Pro Gln Val Gly Arg 
            20              


<210>  272
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM5 Varient

<400>  272

Thr Ala Gln Arg Thr Gln Gln Gln Thr Ala Gly Tyr Gln Gln Pro Gln 
1               5                   10                  15      


Gln Thr Met Ala Tyr 
            20      


<210>  273
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  273

Cys Tyr Ala His Ile Leu Ala Val Leu Leu Val Ser Arg Gly Gln Arg 
1               5                   10                  15      


Arg Leu Arg Ala Met Arg 
            20          


<210>  274
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  274

Gln Val Thr Thr Thr Thr Val Ala Phe Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Val Val Gln Val 
            20          


<210>  275
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  275

Gln Val Thr Thr Thr Thr Val Ala Phe Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Val Gln Val 
            20          


<210>  276
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  276

Gln Val Thr Thr Thr Thr Thr Ala Phe Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Val Gln Val 
            20          


<210>  277
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  277

Gln Val Thr Thr Thr Thr Thr Ala Tyr Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Val Gln Val 
            20          


<210>  278
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  278

Gln Val Thr Thr Thr Thr Thr Ala Phe Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Thr Gln Val 
            20          


<210>  279
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  279

Gln Thr Thr Thr Thr Thr Val Ala Phe Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Thr Gln Val 
            20          


<210>  280
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  280

Gln Val Thr Thr Thr Thr Thr Ala Tyr Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Thr Gln Val 
            20          


<210>  281
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM6 Varient

<400>  281

Gln Thr Thr Thr Thr Thr Thr Ala Tyr Ala Gln Cys Trp Thr Pro Tyr 
1               5                   10                  15      


His Gln Thr Thr Gln Thr 
            20          


<210>  282
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  282

Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn Cys Gly Arg Glu 
1               5                   10                  15      


Ser Arg Val Asp Val 
            20      


<210>  283
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  283

Ala Lys Ser Val Thr Ser Gly Gln Gly Tyr Met His Cys Cys Leu Asn 
1               5                   10                  15      


Pro Leu Gln Tyr Ala Phe Val 
            20              


<210>  284
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  284

Ala Lys Ser Val Thr Ser Gly Gln Gly Tyr Met His Cys Cys Leu Asn 
1               5                   10                  15      


Pro Gln Leu Tyr Ala Phe Thr 
            20              


<210>  285
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  285

Ala Lys Ser Val Thr Ser Gly Gln Gly Tyr Met His Cys Cys Leu Asn 
1               5                   10                  15      


Pro Leu Gln Tyr Ala Phe Thr 
            20              


<210>  286
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  286

Ala Lys Ser Thr Thr Ser Gly Gln Gly Tyr Met His Cys Cys Leu Asn 
1               5                   10                  15      


Pro Gln Gln Tyr Ala Phe Val 
            20              


<210>  287
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  287

Ala Lys Ser Thr Thr Ser Gly Gln Gly Tyr Met His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Leu Gln Tyr Ala Phe Val 
            20              


<210>  288
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  288

Ala Lys Ser Thr Thr Ser Gly Gln Gly Tyr Met His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Leu Tyr Ala Phe Val 
            20              


<210>  289
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  289

Ala Lys Ser Thr Thr Ser Gly Gln Gly Tyr Met His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Leu Gln Tyr Ala Phe Thr 
            20              


<210>  290
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 TM7 Varient

<400>  290

Ala Lys Ser Thr Thr Ser Gly Gln Gly Tyr Met His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Gln Gln Tyr Ala Tyr Thr 
            20              


<210>  291
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 Varient

<400>  291

Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
1               5                   10                  15      


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
            20                  25                  30          


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        35                  40                  45          


<210>  292
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  293
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-1 Varient

<400>  293

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Gln Pro Pro Gln Tyr Ser Gln Thr Tyr Thr Thr Gly 
        35                  40                  45              


Gln Thr Gly Asn Thr Gln Thr Thr Gln Thr Gln Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Thr Tyr Gln Gln Asn Gln Ala Thr Ser Asp 
65                  70                  75                  80  


Gln Gln Tyr Gln Tyr Thr Gln Pro Tyr Trp Thr Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Thr Gln Ser Gly Tyr 
            100                 105                 110         


Tyr Tyr Thr Gly Gln Tyr Ser Glu Thr Tyr Tyr Thr Thr Gln Gln Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Thr Thr Tyr Gly Thr Thr Thr Ser Thr Thr Thr Trp Ala Gln 
145                 150                 155                 160 


Ala Thr Gln Ala Ser Met Pro Gly Gln Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Gln Tyr Gly Gln 
        195                 200                 205             


Thr Gln Pro Gln Gln Thr Met Thr Thr Cys Tyr Thr Gly Thr Thr Lys 
    210                 215                 220                 


Thr Gln Gln Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Gln 
225                 230                 235                 240 


Thr Tyr Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Thr Pro Tyr Asn 
                245                 250                 255     


Gln Thr Thr Gln Thr Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Thr Gln Thr Thr Glu Thr 
        275                 280                 285             


Thr Ala Tyr Thr His Cys Cys Thr Asn Pro Thr Thr Tyr Ala Tyr Thr 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  294
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  295
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-2 Varient

<400>  295

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Gln Pro Pro Gln 
        35                  40                  45              


Tyr Ser Gln Thr Tyr Thr Tyr Gly Tyr Thr Gly Asn Met Gln Thr Thr 
    50                  55                  60                  


Gln Thr Gln Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Gln Gln Asn Gln Ala Thr Ser Asp Gln Gln Tyr Gln Thr Thr Gln Pro 
                85                  90                  95      


Gln Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Gln Tyr His Thr Gly Tyr Tyr Gly Gly Thr 
        115                 120                 125             


Tyr Tyr Thr Thr Gln Gln Thr Thr Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Tyr Gly Thr Thr Thr 
145                 150                 155                 160 


Ser Thr Thr Thr Trp Gln Thr Ala Thr Tyr Ala Ser Thr Pro Gly Thr 
                165                 170                 175     


Thr Tyr Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Thr 
        195                 200                 205             


Gln Gly Gln Thr Gln Pro Gln Gln Thr Met Thr Thr Cys Tyr Ser Gly 
    210                 215                 220                 


Thr Gln Lys Thr Gln Gln Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Thr Arg Thr Thr Tyr Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp 
                245                 250                 255     


Thr Pro Tyr Asn Thr Thr Thr Gln Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Gln Gly Met Thr His Cys Cys Thr Asn Pro Thr Thr 
    290                 295                 300                 


Tyr Ala Tyr Thr Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  296
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  297
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-4 Varient

<400>  297

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Gln 
        35                  40                  45              


Thr Tyr Thr Tyr Gly Gln Gln Gly Asn Ser Thr Thr Thr Gln Thr Gln 
    50                  55                  60                  


Tyr Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Thr Tyr Gln Gln Asn 
65                  70                  75                  80  


Gln Ala Thr Ser Asp Gln Gln Tyr Thr Tyr Ser Gln Pro Tyr Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Thr Ser Trp Met Tyr Gln Thr Gly Tyr Tyr Ser Gly Thr Tyr Tyr Thr 
        115                 120                 125             


Met Gln Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Gln Thr Tyr Gly Thr Thr Thr Ser Gln Ala 
145                 150                 155                 160 


Thr Trp Ser Thr Ala Thr Tyr Ala Ser Gln Pro Gly Tyr Gln Tyr Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Thr Asn Thr 
        195                 200                 205             


Gln Gly Gln Thr Thr Pro Gln Gly Thr Met Gln Tyr Cys Tyr Ser Met 
    210                 215                 220                 


Thr Thr Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Thr Tyr Ala Thr Thr Thr Gln Tyr Gln Gly Tyr Trp Thr 
                245                 250                 255     


Pro Tyr Asn Thr Thr Gln Tyr Gln Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Gln Ala Tyr Thr His Cys Cys Gln Asn Pro Thr Thr Tyr 
    290                 295                 300                 


Tyr Tyr Gln Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  298
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  299
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-6 Varient

<400>  299

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Thr Ala Tyr Ser Gln Thr Cys Thr Tyr Gly Gln Gln Gly Asn 
    50                  55                  60                  


Thr Gln Thr Thr Thr Thr Tyr Ala Tyr Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Gln Gln Asn Met Ala Thr Ala Asp Thr Gln Tyr Thr 
                85                  90                  95      


Gln Thr Gln Pro Tyr Trp Ala Thr Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Thr Tyr Ala Thr Asn 
        115                 120                 125             


Tyr Asn Cys Gly Met Gln Gln Gln Thr Cys Thr Ser Met Asp Arg Tyr 
    130                 135                 140                 


Thr Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Thr Thr Cys Gln Thr Thr Trp Gly Gln Ser Thr 
                165                 170                 175     


Thr Thr Ser Ser Ser Thr Tyr Thr Tyr Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Gln Tyr Gly Tyr Tyr 
    210                 215                 220                 


Thr Pro Gln Met Tyr Met Thr Tyr Cys Tyr Thr Tyr Thr Thr Lys Thr 
225                 230                 235                 240 


Gln Thr Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Thr Thr 
                245                 250                 255     


Thr Ala Thr Thr Gln Thr Tyr Gln Ala Cys Gln Thr Pro His Asn Met 
            260                 265                 270         


Thr Gln Gln Thr Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Thr Gln 
    290                 295                 300                 


Ala Tyr Gln His Cys Cys Gln Asn Pro Thr Gln Tyr Ala Tyr Thr Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  300
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  301
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-7 Varient

<400>  301

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Thr Met 
    50                  55                  60                  


Tyr Ser Thr Thr Cys Tyr Thr Gly Gln Gln Gly Asn Gly Gln Thr Thr 
65                  70                  75                  80  


Gln Thr Tyr Thr Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Gln Gln Asn Gln Ala Thr Ala Asp Thr Gln Tyr Gln Gln Thr Gln Pro 
            100                 105                 110         


Tyr Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Gln Thr Tyr Ala Thr Tyr Lys Met Ser Tyr Tyr Ser Gly Met 
    130                 135                 140                 


Gln Gln Gln Gln Cys Thr Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Thr Gln Gln Thr Ser Lys 
                165                 170                 175     


Gln Ser Cys Thr Gly Thr Trp Thr Gln Ala Thr Thr Gln Ser Thr Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Thr Thr Gly Tyr Gln Thr Pro Gln Gln Ala Met Ser 
225                 230                 235                 240 


Tyr Cys Tyr Gln Thr Thr Thr Arg Thr Gln Gln Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Thr Thr Thr Ala Thr Thr Thr Thr Tyr 
            260                 265                 270         


Thr Thr Tyr Gln Gln Pro Tyr Asn Gly Thr Thr Gln Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Thr Thr Tyr Ser Gln Ala Cys Thr Arg Cys Cys 
305                 310                 315                 320 


Thr Asn Pro Tyr Gln Tyr Ala Tyr Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  302
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  303
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-8 Varient

<400>  303

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Tyr 
        35                  40                  45              


Ser Gln Gln Gly Asn Ser Gln Thr Thr Gln Thr Gln Thr Thr Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Gln Gln Asn Gln Ala Gln Ser 
65                  70                  75                  80  


Asp Gln Gln Tyr Thr Tyr Ser Tyr Pro Tyr Gln Thr Tyr Tyr Gln Gln 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Tyr 
            100                 105                 110         


Tyr Tyr Thr Gly Tyr Tyr Ser Ser Met Tyr Tyr Thr Thr Gln Met Ser 
        115                 120                 125             


Thr Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Gln Ala Thr Trp Gln Thr 
145                 150                 155                 160 


Ala Thr Met Ala Thr Thr Pro Gln Gln Thr Tyr Tyr Gln Thr Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Thr Tyr Thr Asn Tyr Lys Met Asn Thr Gln Gly Gln Gln 
        195                 200                 205             


Thr Pro Tyr Thr Thr Tyr Met Tyr Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Gln Thr 
225                 230                 235                 240 


Gln Thr Thr Thr Thr Ala Ser Gln Gln Tyr Trp Thr Pro Tyr Asn Thr 
                245                 250                 255     


Thr Gln Tyr Gln Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Thr Thr 
        275                 280                 285             


Ser Tyr Thr His Cys Cys Thr Asn Pro Thr Thr Tyr Ala Tyr Thr Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  304
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile 
        35                  40                  45              


Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys 
    50                  55                  60                  


Thr Arg Val Lys Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile 
65                  70                  75                  80  


Ala Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile 
        115                 120                 125             


Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr 
    130                 135                 140                 


Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile 
145                 150                 155                 160 


Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile 
        195                 200                 205             


Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile 
    210                 215                 220                 


Ile Ile His Thr Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Val Thr Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe 
                245                 250                 255     


Pro Tyr Asn Cys Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln 
        275                 280                 285             


Val Thr Gln Thr Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu 
    290                 295                 300                 


Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210>  305
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-9 Varient

<400>  305

Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Gln Tyr Trp Gln Thr Tyr Thr 
        35                  40                  45              


Thr Gly Ala Gln Gly Asn Ser Gln Thr Thr Gln Thr Tyr Trp Tyr Cys 
    50                  55                  60                  


Thr Arg Val Lys Thr Met Thr Asp Met Tyr Gln Gln Asn Gln Ala Thr 
65                  70                  75                  80  


Ala Asp Gln Gln Tyr Gln Thr Thr Gln Pro Tyr Trp Ala Thr Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Tyr Tyr Ser Cys Thr Gln Gln Thr Met Cys Thr 
        115                 120                 125             


Ser Thr Asp Arg Tyr Thr Ala Thr Ala Gln Ala Met Arg Ala His Thr 
    130                 135                 140                 


Trp Arg Glu Lys Arg Gln Gln Tyr Ser Lys Met Thr Cys Tyr Thr Thr 
145                 150                 155                 160 


Trp Thr Gln Ala Ala Ala Gln Cys Thr Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Thr 
        195                 200                 205             


Gln Gly Tyr Tyr Gln Pro Tyr Thr Thr Met Ala Cys Cys Tyr Thr Thr 
    210                 215                 220                 


Thr Thr His Thr Gln Thr Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Thr Thr Thr Thr Thr Gln Thr Thr Tyr Thr Gln Ser Gln Tyr 
                245                 250                 255     


Pro Tyr Asn Cys Thr Gln Gln Thr Gln Thr Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Tyr Gln 
        275                 280                 285             


Thr Thr Gln Thr Thr Ala Tyr Tyr His Ser Cys Gln Asn Pro Thr Gln 
    290                 295                 300                 


Tyr Thr Tyr Thr Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210>  306
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  307
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-10 Varient

<400>  307

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Thr Ser 
        35                  40                  45              


Gln Thr Thr Ala Ala Gln Gly Gln Ala Gly Asn Gly Gln Thr Gln Ala 
    50                  55                  60                  


Thr His Gln Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Gln Gln Gln Gln Ala Gln Ala Asp Gln Gln Gln Ala Gln Thr Gln Pro 
                85                  90                  95      


Tyr Ala Ala Ala Gly Ala Gln Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Gln Tyr Ser Ala Ser Tyr His Ala Gly Tyr 
        115                 120                 125             


Gln Tyr Gln Ala Cys Thr Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Gln 
145                 150                 155                 160 


Thr Ser Thr Thr Thr Trp Gln Gln Ser Gln Gln Gln Ala Gln Pro Ala 
                165                 170                 175     


Gln Gln Tyr Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Thr Ala Gln Thr Ala Gln Gly Tyr Ala Gln Pro Gln Gly Thr Met Thr 
    210                 215                 220                 


Ala Cys Tyr Ala Gln Gln Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Thr Thr Thr Ala Gln Thr Ala Ala Tyr 
                245                 250                 255     


Thr Thr Gln Gln Gln Pro Tyr Ser Gln Ala Gln Gln Gln Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Thr Ala Gln Gln Thr Thr Ser Gly Gln Ala Gln Ala Arg Cys Gly 
    290                 295                 300                 


Gln Asn Pro Thr Gln Tyr Ala Tyr Gln Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  308
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  309
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR1 Varient

<400>  309

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Thr Thr Thr Thr Ala Tyr Ala Gln 
        35                  40                  45              


Thr Tyr Gln Gln Ser Gln Gln Gly Asn Ser Gln Thr Met Gln Thr Thr 
    50                  55                  60                  


Gln Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Thr Tyr Gln Gln Asn 
65                  70                  75                  80  


Gln Ala Gln Ala Asp Gln Gln Tyr Ala Gln Thr Gln Pro Thr Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Tyr Tyr Ser Gly Thr Gln Gln Gln 
        115                 120                 125             


Ala Cys Thr Ser Thr Asp Arg Tyr Gln Ala Thr Thr His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Gln Thr Lys Tyr Thr Cys Gln Gly Cys 
145                 150                 155                 160 


Trp Gly Gln Ser Met Asn Gln Ser Gln Pro Tyr Tyr Gln Tyr Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Tyr Gly Tyr Thr Thr Pro Gln Tyr Thr Met Gln Tyr Cys Tyr Gly Tyr 
    210                 215                 220                 


Thr Gln Arg Thr Gln Tyr Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Thr Thr Tyr Ala Thr Thr Gln Thr Tyr Gln Gln Cys Trp Gln 
                245                 250                 255     


Pro Tyr Asn Gln Thr Gln Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Gln Gly Tyr Gln His Ser Cys Gln Asn Pro Thr Thr 
    290                 295                 300                 


Tyr Ala Tyr Thr Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  310
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Glu Ser Ser Gly Asn Pro Glu Ser Thr Thr Phe Phe Tyr Tyr Asp 
1               5                   10                  15      


Leu Gln Ser Gln Pro Cys Glu Asn Gln Ala Trp Val Phe Ala Thr Leu 
            20                  25                  30          


Ala Thr Thr Val Leu Tyr Cys Leu Val Phe Leu Leu Ser Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Trp Val Leu Val Lys Tyr Glu Ser Leu Glu Ser 
    50                  55                  60                  


Leu Thr Asn Ile Phe Ile Leu Asn Leu Cys Leu Ser Asp Leu Val Phe 
65                  70                  75                  80  


Ala Cys Leu Leu Pro Val Trp Ile Ser Pro Tyr His Trp Gly Trp Val 
                85                  90                  95      


Leu Gly Asp Phe Leu Cys Lys Leu Leu Asn Met Ile Phe Ser Ile Ser 
            100                 105                 110         


Leu Tyr Ser Ser Ile Phe Phe Leu Thr Ile Met Thr Ile His Arg Tyr 
        115                 120                 125             


Leu Ser Val Val Ser Pro Leu Ser Thr Leu Arg Val Pro Thr Leu Arg 
    130                 135                 140                 


Cys Arg Val Leu Val Thr Met Ala Val Trp Val Ala Ser Ile Leu Ser 
145                 150                 155                 160 


Ser Ile Leu Asp Thr Ile Phe His Lys Val Leu Ser Ser Gly Cys Asp 
                165                 170                 175     


Tyr Ser Glu Leu Thr Trp Tyr Leu Thr Ser Val Tyr Gln His Asn Leu 
            180                 185                 190         


Phe Phe Leu Leu Ser Leu Gly Ile Ile Leu Phe Cys Tyr Val Glu Ile 
        195                 200                 205             


Leu Arg Thr Leu Phe Arg Ser Arg Ser Lys Arg Arg His Arg Thr Val 
    210                 215                 220                 


Lys Leu Ile Phe Ala Ile Val Val Ala Tyr Phe Leu Ser Trp Gly Pro 
225                 230                 235                 240 


Tyr Asn Phe Thr Leu Phe Leu Gln Thr Leu Phe Arg Thr Gln Ile Ile 
                245                 250                 255     


Arg Ser Cys Glu Ala Lys Gln Gln Leu Glu Tyr Ala Leu Leu Ile Cys 
            260                 265                 270         


Arg Asn Leu Ala Phe Ser His Cys Cys Phe Asn Pro Val Leu Tyr Val 
        275                 280                 285             


Phe Val Gly Val Lys Phe Arg Thr His Leu Lys His Val Leu Arg Gln 
    290                 295                 300                 


Phe Trp Phe Cys Arg Leu Gln Ala Pro Ser Pro Ala Ser Ile Pro His 
305                 310                 315                 320 


Ser Pro Gly Ala Phe Ala Tyr Glu Gly Ala Ser Phe Tyr 
                325                 330             


<210>  311
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXR Varient

<400>  311

Met Glu Ser Ser Gly Asn Pro Glu Ser Thr Thr Phe Phe Tyr Tyr Asp 
1               5                   10                  15      


Leu Gln Ser Gln Pro Cys Glu Asn Gln Ala Trp Val Phe Ala Thr Leu 
            20                  25                  30          


Ala Thr Thr Thr Gln Tyr Cys Gln Thr Tyr Gln Gln Ser Gln Thr Gly 
        35                  40                  45              


Asn Ser Gln Thr Gln Trp Thr Gln Val Lys Tyr Glu Ser Leu Glu Ser 
    50                  55                  60                  


Leu Thr Asn Thr Tyr Thr Gln Asn Gln Cys Gln Ser Asp Gln Thr Tyr 
65                  70                  75                  80  


Ala Cys Gln Gln Pro Thr Trp Thr Ser Pro Tyr His Trp Gly Trp Val 
                85                  90                  95      


Leu Gly Asp Phe Leu Cys Lys Leu Leu Asn Met Ile Phe Ser Thr Ser 
            100                 105                 110         


Gln Tyr Ser Ser Thr Tyr Tyr Gln Thr Thr Met Thr Thr His Arg Tyr 
        115                 120                 125             


Gln Ser Thr Thr Ser Pro Leu Ser Thr Leu Arg Val Pro Thr Leu Arg 
    130                 135                 140                 


Cys Arg Thr Gln Thr Thr Met Ala Thr Trp Thr Ala Ser Thr Gln Ser 
145                 150                 155                 160 


Ser Thr Gln Asp Thr Thr Tyr His Lys Val Leu Ser Ser Gly Cys Asp 
                165                 170                 175     


Tyr Ser Glu Leu Thr Trp Tyr Leu Thr Ser Thr Tyr Gln His Asn Gln 
            180                 185                 190         


Tyr Tyr Gln Gln Ser Gln Gly Thr Thr Gln Tyr Cys Tyr Thr Glu Thr 
        195                 200                 205             


Gln Arg Thr Leu Phe Arg Ser Arg Ser Lys Arg Arg His Arg Thr Val 
    210                 215                 220                 


Lys Gln Thr Tyr Ala Thr Thr Thr Ala Tyr Tyr Gln Ser Trp Gly Pro 
225                 230                 235                 240 


Tyr Asn Tyr Thr Gln Tyr Gln Gln Thr Leu Phe Arg Thr Gln Ile Ile 
                245                 250                 255     


Arg Ser Cys Glu Ala Lys Gln Gln Leu Glu Tyr Ala Gln Gln Thr Cys 
            260                 265                 270         


Arg Asn Gln Ala Tyr Ser His Cys Cys Tyr Asn Pro Thr Gln Tyr Thr 
        275                 280                 285             


Tyr Thr Gly Val Lys Phe Arg Thr His Leu Lys His Val Leu Arg Gln 
    290                 295                 300                 


Phe Trp Phe Cys Arg Leu Gln Ala Pro Ser Pro Ala Ser Ile Pro His 
305                 310                 315                 320 


Ser Pro Gly Ala Phe Ala Tyr Glu Gly Ala Ser Phe Tyr 
                325                 330             


<210>  312
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  313
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR2 Varient

<400>  313

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Thr Thr Thr Thr Tyr Ala Gln Thr Tyr Gln Gln Ser Gln Gln 
    50                  55                  60                  


Gly Asn Ser Gln Thr Met Gln Thr Thr Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Thr Tyr Gln Gln Asn Gln Ala Gln Ala Asp Gln Gln 
                85                  90                  95      


Tyr Ala Gln Thr Gln Pro Thr Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Thr 
        115                 120                 125             


Asn Tyr Tyr Ser Gly Thr Gln Gln Gln Ala Cys Thr Ser Thr Asp Arg 
    130                 135                 140                 


Tyr Gln Ala Thr Thr His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Gln Thr Lys Tyr Thr Cys Gln Ser Thr Trp Gly Gln Ser Gln Gln Gln 
                165                 170                 175     


Ala Gln Pro Thr Gln Gln Tyr Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Tyr Gly Tyr Thr Thr Pro Gln 
    210                 215                 220                 


Gln Thr Met Gln Tyr Cys Tyr Gly Tyr Thr Gln Arg Thr Gln Tyr Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Thr Thr Tyr Ala Thr 
                245                 250                 255     


Thr Gln Thr Tyr Gln Gln Cys Trp Gln Pro Tyr Asn Gln Thr Gln Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Thr Gln Gly Thr 
    290                 295                 300                 


Gln His Ser Cys Gln Asn Pro Gln Thr Tyr Ala Tyr Thr Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  314
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  315
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR-10 Varient

<400>  315

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Thr Pro Thr Ala Tyr Ser Gln Thr Tyr Gln Gln 
    50                  55                  60                  


Gly Thr Thr Gly Asn Thr Gln Thr Gln Thr Thr Gln Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Tyr Gln Tyr His Gln Ala Thr Ala 
                85                  90                  95      


Asp Gln Gln Gln Thr Tyr Thr Gln Pro Tyr Ala Thr Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Thr Ala Gln 
        115                 120                 125             


His Lys Thr Asn Tyr Tyr Cys Ser Ser Gln Gln Gln Ala Cys Thr Ala 
    130                 135                 140                 


Thr Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Thr His Thr Thr Cys Gly Thr Thr Trp Gln Thr 
                165                 170                 175     


Gly Tyr Gln Gln Ala Gln Pro Glu Thr Gln Tyr Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Tyr Gln Tyr His Thr 
    210                 215                 220                 


Ala Gly Tyr Gln Gln Pro Met Gln Thr Met Gly Trp Cys Tyr Thr Gly 
225                 230                 235                 240 


Thr Thr His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Thr Arg Thr Ala Thr Gln Thr Thr Ser Thr Tyr Tyr Gln Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Thr Thr Thr Tyr Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Gln Pro Thr Ala Thr 
    290                 295                 300                 


Thr Met Cys Glu Tyr Gln Gly Gln Ala His Cys Cys Gln Asn Pro Met 
305                 310                 315                 320 


Gln Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  316
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  317
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR6 Varient

<400>  317

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Gln Thr Thr Tyr Thr Cys Gly Gln Thr Gly 
        35                  40                  45              


Asn Ser Gln Thr Gln Thr Thr Ser Thr Tyr Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Thr Tyr Gln Thr Asn Gln Pro Gln Ala Asp Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Thr Gln Pro Tyr Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Thr Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Met Gln Thr Gln Thr Cys Thr Thr Thr Asp Arg Tyr 
        115                 120                 125             


Thr Thr Thr Thr Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Gln Gln Thr Trp Thr Thr Ser Gln 
145                 150                 155                 160 


Gln Thr Ser Gln Pro Gln Thr Thr Tyr Gly Asn Thr Tyr Asn Gln Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Thr Thr Gln 
            180                 185                 190         


Ala Thr Gln Met Thr Gln Gly Tyr Tyr Gln Pro Gln Gln Thr Met Thr 
        195                 200                 205             


Thr Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Thr Thr Tyr Gln Thr Met Ala Thr Tyr 
225                 230                 235                 240 


Gln Gln Thr Gln Met Pro Tyr Asn Gln Met Lys Tyr Thr Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Thr Met Thr 
            260                 265                 270         


Thr Glu Ala Thr Ala Tyr Gln Arg Ala Cys Gln Asn Pro Thr Gln Tyr 
        275                 280                 285             


Ala Tyr Thr Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  318
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser 
        35                  40                  45              


Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val 
    50                  55                  60                  


Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His 
65                  70                  75                  80  


Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr 
                85                  90                  95      


Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu 
        115                 120                 125             


Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val 
145                 150                 155                 160 


Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser 
                165                 170                 175     


Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro 
    210                 215                 220                 


Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser 
                245                 250                 255     


Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val 
            260                 265                 270         


Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser 
    290                 295                 300                 


Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys 
        355                 360         


<210>  319
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR7 Varient

<400>  319

Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp 
1               5                   10                  15      


Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val 
            20                  25                  30          


Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Gln Ser 
        35                  40                  45              


Tyr Thr Tyr Thr Tyr Thr Tyr Thr Thr Gly Met Thr Ala Asn Ser Thr 
    50                  55                  60                  


Thr Thr Trp Thr Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His 
65                  70                  75                  80  


Cys Tyr Thr Gln Asn Gln Ala Thr Ala Asp Gln Trp Thr Thr Gln Thr 
                85                  90                  95      


Thr Pro Thr Trp Thr Thr Ser Gln Val Gln His Asn Gln Trp Pro Met 
            100                 105                 110         


Gly Glu Leu Thr Cys Lys Thr Thr His Gln Thr Tyr Ser Thr Asn Gln 
        115                 120                 125             


Tyr Gly Ser Thr Tyr Tyr Gln Thr Cys Met Ser Thr Asp Arg Tyr Leu 
    130                 135                 140                 


Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Thr 
145                 150                 155                 160 


Arg Arg Thr Thr Cys Thr Gln Thr Trp Gln Gln Ala Tyr Cys Thr Ser 
                165                 170                 175     


Gln Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn 
            180                 185                 190         


Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp 
        195                 200                 205             


Leu Ile Gly Met Glu Gln Thr Ser Thr Thr Gln Gly Tyr Ala Thr Pro 
    210                 215                 220                 


Tyr Ser Thr Thr Ala Thr Tyr Tyr Tyr Gln Gln Ala Arg Ala Ile Ser 
225                 230                 235                 240 


Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Tyr Ser 
                245                 250                 255     


Tyr Thr Thr Thr Tyr Gln Thr Cys Trp Gln Pro Tyr His Thr Ala Thr 
            260                 265                 270         


Gln Gln Asp Thr Tyr Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg 
        275                 280                 285             


Leu Glu His Ala Leu Phe Thr Ala Gln His Thr Thr Gln Cys Gln Ser 
    290                 295                 300                 


Gln Thr His Cys Cys Thr Asn Pro Thr Gln Tyr Ser Tyr Thr Asn Arg 
305                 310                 315                 320 


Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala 
                325                 330                 335     


Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr 
            340                 345                 350         


Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys 
        355                 360         


<210>  320
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  321
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLR-1a Varient

<400>  321

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Thr Tyr Gln Thr Thr Thr Tyr Ser 
        35                  40                  45              


Thr Thr Cys Tyr Gln Gly Thr Gln Gly Asn Gly Gln Thr Thr Thr Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Thr Trp Tyr Gln Asn 
65                  70                  75                  80  


Gln Ala Thr Ala Asp Tyr Gln Tyr Asn Thr Tyr Gln Pro Thr His Thr 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Gln Gln Thr His Asn Met Tyr Thr Ser Thr Tyr 
        115                 120                 125             


Gln Gln Thr Thr Thr Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Gln Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Thr Thr Trp Thr Gln Ala Tyr Tyr Gln Ser Ser Pro Ser Gln Thr 
                165                 170                 175     


Tyr Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Tyr Gln Cys Gly Tyr Gln Thr Pro Thr Gln Thr Thr Thr Ala Cys Tyr 
225                 230                 235                 240 


Gln Thr Thr Thr Cys Lys Gln Gln Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Tyr Lys Thr Thr Thr Thr Thr Thr Thr Thr Tyr Tyr Gln Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Gln Asn Gln Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Gln Gly Gln Pro Gln Ala Thr Ala Gln 
    290                 295                 300                 


Ala Thr Ala Asn Ser Cys Met Asn Pro Thr Gln Tyr Thr Tyr Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  322
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Ala Ser Ser Gly Tyr Val Leu Gln Ala Glu Leu Ser Pro Ser Thr 
1               5                   10                  15      


Glu Asn Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr 
            20                  25                  30          


Gly Val Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu 
        35                  40                  45              


Ala Ala Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Leu 
    50                  55                  60                  


Pro Phe Phe Ile Leu Thr Ser Val Leu Gly Ile Leu Ala Ser Ser Thr 
65                  70                  75                  80  


Val Leu Phe Met Leu Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro 
                85                  90                  95      


Gly Trp Pro Val Leu Ala Gln Leu Ala Val Gly Ser Ala Leu Phe Ser 
            100                 105                 110         


Ile Val Val Pro Val Leu Ala Pro Gly Leu Gly Ser Thr Arg Ser Ser 
        115                 120                 125             


Ala Leu Cys Ser Leu Gly Tyr Cys Val Trp Tyr Gly Ser Ala Phe Ala 
    130                 135                 140                 


Gln Ala Leu Leu Leu Gly Cys His Ala Ser Leu Gly His Arg Leu Gly 
145                 150                 155                 160 


Ala Gly Gln Val Pro Gly Leu Thr Leu Gly Leu Thr Val Gly Ile Trp 
                165                 170                 175     


Gly Val Ala Ala Leu Leu Thr Leu Pro Val Thr Leu Ala Ser Gly Ala 
            180                 185                 190         


Ser Gly Gly Leu Cys Thr Leu Ile Tyr Ser Thr Glu Leu Lys Ala Leu 
        195                 200                 205             


Gln Ala Thr His Thr Val Ala Cys Leu Ala Ile Phe Val Leu Leu Pro 
    210                 215                 220                 


Leu Gly Leu Phe Gly Ala Lys Gly Leu Lys Lys Ala Leu Gly Met Gly 
225                 230                 235                 240 


Pro Gly Pro Trp Met Asn Ile Leu Trp Ala Trp Phe Ile Phe Trp Trp 
                245                 250                 255     


Pro His Gly Val Val Leu Gly Leu Asp Phe Leu Val Arg Ser Lys Leu 
            260                 265                 270         


Leu Leu Leu Ser Thr Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Leu 
        275                 280                 285             


Asn Leu Ala Glu Ala Leu Ala Ile Leu His Cys Val Ala Thr Pro Leu 
    290                 295                 300                 


Leu Leu Ala Leu Phe Cys His Gln Ala Thr Arg Thr Leu Leu Pro Ser 
305                 310                 315                 320 


Leu Pro Leu Pro Glu Gly Trp Ser Ser His Leu Asp Thr Leu Gly Ser 
                325                 330                 335     


Lys Ser 
        


<210>  323
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DARIA Varient

<400>  323

Met Ala Ser Ser Gly Tyr Val Leu Gln Ala Glu Leu Ser Pro Ser Thr 
1               5                   10                  15      


Glu Asn Ser Ser Gln Leu Asp Phe Glu Asp Val Trp Asn Ser Ser Tyr 
            20                  25                  30          


Gly Val Asn Asp Ser Phe Pro Asp Gly Asp Tyr Gly Ala Asn Leu Glu 
        35                  40                  45              


Ala Ala Ala Pro Cys His Ser Cys Asn Leu Leu Asp Asp Ser Ala Gln 
    50                  55                  60                  


Pro Tyr Tyr Thr Gln Thr Ser Thr Gln Gly Thr Gln Ala Ser Ser Thr 
65                  70                  75                  80  


Thr Gln Tyr Met Gln Phe Arg Pro Leu Phe Arg Trp Gln Leu Cys Pro 
                85                  90                  95      


Gly Trp Pro Thr Gln Ala Gln Gln Ala Thr Gly Ser Ala Gln Tyr Ser 
            100                 105                 110         


Thr Thr Thr Pro Thr Gln Ala Pro Gly Leu Gly Ser Thr Arg Ser Ser 
        115                 120                 125             


Ala Leu Cys Ser Leu Gly Tyr Cys Thr Trp Tyr Gly Ser Ala Tyr Ala 
    130                 135                 140                 


Gln Ala Gln Gln Gln Gly Cys His Ala Ser Gln Gly His Arg Leu Gly 
145                 150                 155                 160 


Ala Gly Gln Val Pro Gly Leu Thr Gln Gly Gln Thr Thr Gly Thr Trp 
                165                 170                 175     


Gly Thr Ala Ala Gln Gln Thr Gln Pro Thr Thr Gln Ala Ser Gly Ala 
            180                 185                 190         


Ser Gly Gly Leu Cys Thr Leu Ile Tyr Ser Thr Glu Leu Lys Ala Leu 
        195                 200                 205             


Gln Ala Thr His Thr Thr Ala Cys Gln Ala Thr Tyr Thr Gln Gln Pro 
    210                 215                 220                 


Gln Gly Gln Tyr Gly Ala Lys Gly Gln Lys Lys Ala Leu Gly Met Gly 
225                 230                 235                 240 


Pro Gly Pro Trp Met Asn Thr Gln Trp Ala Trp Tyr Thr Tyr Trp Trp 
                245                 250                 255     


Pro His Gly Thr Thr Gln Gly Gln Asp Tyr Gln Thr Arg Ser Lys Leu 
            260                 265                 270         


Leu Leu Leu Ser Thr Cys Leu Ala Gln Gln Ala Leu Asp Leu Leu Gln 
        275                 280                 285             


Asn Gln Ala Glu Ala Gln Ala Thr Gln His Cys Thr Ala Thr Pro Gln 
    290                 295                 300                 


Gln Gln Ala Gln Tyr Cys His Gln Ala Thr Arg Thr Leu Leu Pro Ser 
305                 310                 315                 320 


Leu Pro Leu Pro Glu Gly Trp Ser Ser His Leu Asp Thr Leu Gly Ser 
                325                 330                 335     


Lys Ser 
        


<210>  324
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 
1               5                   10                  15      


Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 
            20                  25                  30          


Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 
    50                  55                  60                  


Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 
                85                  90                  95      


Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 
        195                 200                 205             


Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  325
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 Varient

<400>  325

Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Gln Gln Tyr Thr 
1               5                   10                  15      


Tyr Asn Tyr Thr Tyr Trp Gln Ala Gly Gly Thr Thr Gln Gly Thr Ala 
            20                  25                  30          


Gln Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 
        35                  40                  45              


Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Thr 
    50                  55                  60                  


Gln Thr Ala Thr Gly Ala Thr Met Met Tyr Thr Gly Tyr Gln Gly Cys 
65                  70                  75                  80  


Tyr Gly Ala Thr Gln Glu Ser Gln Cys Gln Gln Gly Thr Tyr Tyr Thr 
                85                  90                  95      


Cys Gln Thr Thr Gln Tyr Ala Cys Glu Thr Ala Ala Gly Thr Trp Gly 
            100                 105                 110         


Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 
        115                 120                 125             


Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 
    130                 135                 140                 


Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 
                165                 170                 175     


Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 
            180                 185                 190         


Lys Ile Asp Asp Leu Phe Ser Gly Lys Gln Tyr Gln Thr Gly Thr Ala 
        195                 200                 205             


Ala Thr Thr Thr Ala Thr Thr Met Thr Tyr Glu Met Thr Gln Ser Met 
    210                 215                 220                 


Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 
225                 230                 235     


<210>  326
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM1 Varient

<400>  326

Leu Phe Val Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu 
1               5                   10                  15      


Gly Val Ala Leu Trp 
            20      


<210>  327
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM1 Varient

<400>  327

Gln Tyr Thr Tyr Asn Tyr Thr Tyr Trp Gln Ala Gly Gly Thr Thr Gln 
1               5                   10                  15      


Gly Thr Ala Gln Trp 
            20      


<210>  328
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM2 Varient

<400>  328

Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 
1               5                   10                  15      


Tyr Gly Ala Ile Gln 
            20      


<210>  329
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM2 Varient

<400>  329

Gln Thr Ala Thr Gly Ala Thr Met Met Tyr Thr Gly Tyr Gln Gly Cys 
1               5                   10                  15      


Tyr Gly Ala Thr Gln 
            20      


<210>  330
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM3 Varient

<400>  330

Leu Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe Ala Cys Glu Val 
1               5                   10                  15      


Ala Ala Gly Ile Trp Gly Phe 
            20              


<210>  331
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM3 Varient

<400>  331

Gln Gly Thr Tyr Tyr Thr Cys Gln Thr Thr Gln Tyr Ala Cys Glu Thr 
1               5                   10                  15      


Ala Ala Gly Thr Trp Gly Phe 
            20              


<210>  332
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM4 Varient

<400>  332

Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile Met Ile Phe 
1               5                   10                  15      


Glu Met Ile Leu Ser Met Val 
            20              


<210>  333
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD81 TM4 Varient

<400>  333

Tyr Gln Thr Gly Thr Ala Ala Thr Thr Thr Ala Thr Thr Met Thr Tyr 
1               5                   10                  15      


Glu Met Thr Gln Ser Met Val 
            20              


<210>  334
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTY Fc Hinge Region

<400>  334

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
1               5                   10                  15      


Pro Asn Leu Leu Gly Gly Pro 
            20              


<210>  335
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR9-QTY Fc

<400>  335

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Tyr Gln Pro Pro Gln Tyr Trp Gln Thr Tyr Thr Thr Gly Ala Gln 
    50                  55                  60                  


Gly Asn Ser Gln Thr Thr Gln Thr Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Tyr Gln Gln Asn Gln Ala Thr Ala Asp Gln Gln 
                85                  90                  95      


Tyr Gln Thr Thr Gln Pro Tyr Trp Ala Thr Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Thr Phe Met Cys Lys Thr Thr Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Tyr Tyr Ser Cys Thr Gln Gln Thr Met Cys Thr Ser Thr Asp Arg 
    130                 135                 140                 


Tyr Thr Ala Thr Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Gln Gln Tyr Ser Lys Met Thr Cys Tyr Thr Thr Trp Thr Gln Ala 
                165                 170                 175     


Ala Ala Gln Cys Thr Pro Glu Thr Gln Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr 
        195                 200                 205             


Lys Gln Lys Ser Ala Thr Gln Thr Gln Lys Thr Thr Gln Gly Tyr Tyr 
    210                 215                 220                 


Gln Pro Tyr Thr Thr Met Ala Cys Cys Tyr Thr Thr Thr Thr His Thr 
225                 230                 235                 240 


Gln Thr Gln Ala Lys Lys Ser Ser Lys His Lys Ala Gln Lys Thr Thr 
                245                 250                 255     


Thr Thr Thr Gln Thr Thr Tyr Thr Gln Ser Gln Tyr Pro Tyr Asn Cys 
            260                 265                 270         


Thr Gln Gln Thr Gln Thr Thr Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Ala Thr Ser Thr Asn Thr Asp Thr Cys Tyr Gln Thr Thr Gln Thr 
    290                 295                 300                 


Thr Ala Tyr Tyr His Ser Cys Gln Asn Pro Thr Gln Tyr Thr Tyr Thr 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu Thr Glu Thr Ser Gln Val Ala Pro Ala His His His His His His 
    370                 375                 380                 


His His His His Thr Glu Thr Ser Gln Val Ala Pro Ala His His His 
385                 390                 395                 400 


His His His His His His His Gly Ser Lys Leu Val Asp Pro Arg Gly 
                405                 410                 415     


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
            420                 425                 430         


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
        435                 440                 445             


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
    450                 455                 460                 


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
465                 470                 475                 480 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
                485                 490                 495     


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
            500                 505                 510         


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
        515                 520                 525             


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
    530                 535                 540                 


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
545                 550                 555                 560 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
                565                 570                 575     


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
            580                 585                 590         


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
        595                 600                 605             


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
    610                 615                 620                 


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
625                 630                 635                 640 


Arg Thr Pro Gly Lys 
                645 


<210>  336
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR2-QTY Fc

<400>  336

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Tyr Thr Thr Thr Thr Tyr Ala Gln Thr Tyr Gln Gln Ser Gln Gln 
    50                  55                  60                  


Gly Asn Ser Gln Thr Met Gln Thr Thr Gln Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Thr Tyr Gln Gln Asn Gln Ala Gln Ala Asp Gln Gln 
                85                  90                  95      


Tyr Ala Gln Thr Gln Pro Thr Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Thr Thr Ser Gln Gln Lys Glu Thr 
        115                 120                 125             


Asn Tyr Tyr Ser Gly Thr Gln Gln Gln Ala Cys Thr Ser Thr Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Tyr Thr Cys Gln Ser Thr Trp Gly Gln Ser Gln Gln Gln 
                165                 170                 175     


Ala Gln Pro Thr Gln Gln Tyr Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Gln Gln Arg Thr Gln Pro Gln Ser Tyr Gly Tyr Thr Gln Pro Gln 
    210                 215                 220                 


Gln Thr Met Gln Tyr Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Thr Thr Tyr Ala Thr 
                245                 250                 255     


Thr Gln Thr Tyr Gln Gln Cys Trp Gln Pro Tyr Asn Gln Thr Gln Gln 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Gln Asp Ala Thr Glu Thr Gln Gly Thr 
    290                 295                 300                 


Gln His Ser Cys Gln Asn Pro Gln Thr Tyr Ala Tyr Thr Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu Thr Glu Thr Ser Gln Val Ala Pro 
        355                 360                 365             


Ala His His His His His His His His His His Gly Ser Lys Leu Val 
    370                 375                 380                 


Asp Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
385                 390                 395                 400 


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                405                 410                 415     


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        435                 440                 445             


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    450                 455                 460                 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
465                 470                 475                 480 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                485                 490                 495     


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            500                 505                 510         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        515                 520                 525             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    530                 535                 540                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
545                 550                 555                 560 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                565                 570                 575     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            580                 585                 590         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        595                 600                 605             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    610                 615         


<210>  337
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
            100                 105                 110         


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg 
        115                 120                 125             


Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val 
    130                 135                 140                 


Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile 
            180                 185                 190         


Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp Gly 
    210                 215                 220                 


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
            260                 265                 270         


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
        275                 280                 285             


Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val 
    290                 295                 300                 


Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu 
305                 310                 315                 320 


Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly 
            340                 345                 350         


Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
        355                 360                 365             


Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210>  338
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 varient

<400>  338

Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Gln Tyr Ser Gln Gln Tyr Gln 
            100                 105                 110         


Gln Gly Gln Gln Gly Asn Gly Ala Thr Ala Ala Thr Gln Gln Ser Arg 
        115                 120                 125             


Arg Thr Ala Leu Ser Ser Thr Asp Thr Tyr Gln Gln His Gln Ala Thr 
    130                 135                 140                 


Ala Asp Thr Gln Gln Thr Gln Thr Gln Pro Gln Trp Ala Thr Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Gln Tyr Asn Thr Asn Tyr Tyr Ala Gly Ala Gln Gln Gln Ala Cys Thr 
            180                 185                 190         


Ser Tyr Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Thr Thr Gln Thr Cys Gln Ala Thr Trp Gly 
    210                 215                 220                 


Gln Cys Gln Gln Tyr Ala Gln Pro Asp Tyr Thr Tyr Gln Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Thr Ala Gly Tyr Gln 
            260                 265                 270         


Gln Pro Gln Gln Thr Met Ala Tyr Cys Tyr Ala His Thr Gln Ala Thr 
        275                 280                 285             


Gln Gln Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Gln Thr 
    290                 295                 300                 


Thr Thr Thr Thr Thr Ala Tyr Ala Gln Cys Trp Thr Pro Tyr His Gln 
305                 310                 315                 320 


Thr Thr Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly 
            340                 345                 350         


Gln Gly Tyr Met His Cys Cys Gln Asn Pro Gln Gln Tyr Ala Tyr Thr 
        355                 360                 365             


Gly Thr Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210>  339
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR3 varient

<400>  339

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg 
    50              


<210>  340
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCR4 TM7 Variant

<400>  340

Trp Thr Ser Thr Thr Glu Ala Gln Ala Tyr Tyr His Cys Cys Gln Asn 
1               5                   10                  15      


Pro Thr Gln Tyr 
            20  


<210>  341
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CCR5 TM6 Varient

<400>  341

Gln Thr Tyr Thr Thr Met Thr Thr Tyr Tyr Gln Tyr Trp Ala Pro Tyr 
1               5                   10                  15      


Asn Thr Thr Gln Gln Gln Asn Thr Tyr 
            20                  25  


