                         SEQUENCE LISTING – Amendment – Rule 13ter

<110>  DIOSynVax Ltd
       The Chancellor, Masters and Scholars of the University of 
       Cambridge
 
<120>  Coronavirus Vaccines

<130>  P/82043.WO01

<150>  2004826.0
<151>  2020-04-01

<150>  2010672.0
<151>  2020-07-10

<150>  2015775.6
<151>  2020-10-05

<150>  2101824.7
<151>  2021-02-10

<150>  2103214.9
<151>  2021-03-08

<160>        

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein sequence

<400>  1

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1190                 1195                 1200             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1205                 1210                 1215             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1220                 1225                 1230             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1235                 1240                 1245             


Gly Val  Lys Leu His Tyr Thr  
    1250                 1255 


<210>  2
<211>  3765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein sequence

<400>  2
atgtttatct ttctgctgtt tctgaccctg accagcggca gcgacctgga tagatgcacc       60

accttcgacg atgtgcaggc ccctaactac acccagcaca ccagctctat gcggggcgtg      120

tactaccccg acgagatttt cagaagcgac accctgtatc tgacccagga cctgttcctg      180

cctttctaca gcaacgtgac cggcttccac accatcaacc acaccttcgg caaccctgtg      240

atccccttca aggacggcat ctactttgcc gccaccgaga agtccaacgt cgtcagagga      300

tgggtgttcg gcagcaccat gaacaacaag agccagagcg tgatcatcat caacaacagc      360

accaacgtgg tcatccgggc ctgcaacttc gagctgtgcg acaacccatt cttcgccgtg      420

tccaagccta tgggcaccca gacacacacc atgatcttcg acaacgcctt caactgcacc      480

ttcgagtaca tcagcgacgc cttcagcctg gacgtgtccg aaaagagcgg caacttcaag      540

cacctgaggg aattcgtgtt caagaacaag gatggcttcc tgtacgtgta caagggctac      600

cagcctatcg acgtcgtgcg ggatctgccc agcggcttca ataccctgaa gcctatcttc      660

aagctgcccc tgggcatcaa catcaccaac ttcagagcca tcctgaccgc tttcagcccc      720

gctcaggata tctggggaac aagcgccgct gcctacttcg tgggctacct gaagccaacc      780

accttcatgc tgaagtacga cgagaacggc accatcaccg acgccgtgga ctgtagccaa      840

aatcctctgg ccgagctgaa gtgcagcgtg aagtccttcg agatcgacaa gggcatctac      900

cagaccagca atttcagagt ggtgccctcc ggggatgtcg tgcggttccc caacatcaca      960

aatctgtgcc ccttcggcga ggtgttcaac gccaccaagt ttccctctgt gtacgcctgg     1020

gagcgcaaaa agatcagcaa ctgcgtggcc gactacagcg tgctgtacaa ctccaccttc     1080

ttcagcacct tcaagtgcta cggcgtgtcc gccacaaagc tgaacgacct gtgcttctcc     1140

aacgtgtacg ccgacagctt cgtggtcaaa ggcgacgacg ttcggcagat tgcccctgga     1200

caaacaggcg tgatcgccga ttacaactac aagctgcctg acgacttcat gggctgcgtg     1260

ctggcctgga acaccagaaa catcgatgcc acctccaccg gcaactacaa ttacaagtac     1320

agatacctgc ggcacggcaa gctgcggcct ttcgagaggg atatcagcaa tgtgcctttt     1380

agccccgacg gcaagccctg cacacctcct gctctgaatt gctactggcc cctgaacgac     1440

tacggctttt acaccaccac aggcatcggc tatcagccct atagagtggt ggtcctgtcc     1500

tttgagctgc tgaatgcccc tgccacagtg tgcggaccta agctgtctac cgacctgatc     1560

aagaaccagt gcgtgaactt caacttcaac ggcctgaccg gcaccggcgt gctgacacca     1620

agcagcaaga gattccagcc tttccagcag ttcggccggg atgtgtccga cttcacagac     1680

agcgtcagag atcccaagac cagcgagatc ctggacatca gcccttgtgc ctttggcgga     1740

gtgtccgtga tcacccctgg cacaaatgcc tctagcgaag tggccgtgct gtatcaggac     1800

gtgaactgca ccgatgtgtc caccgccatt cacgccgatc agctgactcc cgcttggcgg     1860

atctatagca caggcaacaa cgtgttccag acacaagccg gctgtctgat cggagccgag     1920

catgtggata ccagctacga gtgcgacatc cctatcggcg ctggcatctg tgcctcttac     1980

cacaccgtgt ctctgctgcg gagcaccagc cagaaatcca tcgtggccta caccatgagc     2040

ctgggcgccg attcttctat cgcctactcc aacaacacaa tcgctatccc caccaatttc     2100

agcatctcca tcaccaccga agtgatgccc gtgtccatgg ccaagacctc cgtggattgc     2160

aacatgtaca tctgcggcga cagcaccgag tgcgccaatc tgctgctcca gtacggcagc     2220

ttctgcaccc agctgaatag agccctgtct ggaattgccg ccgagcagga cagaaacacc     2280

agagaagtgt tcgcccaagt gaagcagatg tataagaccc cgacactcaa gtacttcggc     2340

gggttcaact tctcccagat cctgcctgat cctctgaagc ccaccaagcg gagcttcatc     2400

gaggacctgc tgttcaacaa agtgaccctg gccgacgccg gctttatgaa gcagtatggc     2460

gagtgcctgg gcgacatcaa cgccagggat ctgatttgcg cccagaagtt taacggactg     2520

accgtgctgc ctcctctgct gaccgatgat atgatcgccg cctacacagc cgctctggtg     2580

tctggtacag ctaccgccgg atggacattt ggagctggcg ccgctctcca gattccattc     2640

gctatgcaga tggcctaccg gttcaacggc atcggagtga cccagaatgt gctgtacgag     2700

aatcagaagc agatcgccaa tcagttcaac aaggccatca gccagatcca agagagcctg     2760

accaccacaa gcacagccct gggaaagctc caggacgtgg tcaaccagaa tgctcaggcc     2820

ctgaacaccc tggtcaagca gctgagcagc aacttcggcg ccatcagctc cgtgctgaat     2880

gacatcctga gccggctgga caaggtggaa gcagaggtgc agatcgaccg gctgatcaca     2940

ggcagactcc agagcctcca gacctacgtg acacagcagc tgatcagagc cgccgagatt     3000

agagcctctg ccaatctggc cgccaccaaa atgagcgagt gtgtcctggg ccagagcaag     3060

agagtggact tttgcggcaa gggctatcac ctgatgagct tcccacaggc cgctcctcat     3120

ggcgtggtct ttctgcacgt gacatacgtg cccagccaag agagaaactt caccaccgct     3180

ccagccatct gccacgaggg caaagcctac tttcccagag aaggcgtgtt cgtgtttaac     3240

ggcacctcct ggtttatcac ccagcggaat ttcttcagcc cgcaaatcat caccacagac     3300

aacaccttcg tgtccggcaa ctgtgacgtc gtgatcggca tcattaacaa taccgtgtac     3360

gaccctctcc agcctgagct ggacagcttc aaagaggaac tggataagta cttcaagaat     3420

cacacgagcc ccgatgtgga cctgggcgat atctctggca tcaatgccag cgtcgtgaac     3480

atccagaaag agattgacag gctgaacgag gtggccaaga acctgaacga gtccctgatc     3540

gacctgcaag agctggggaa gtacgagcag tacatcaagt ggccttggta cgtgtggctg     3600

ggctttatcg ccggactgat cgccatcgtg atggtcacca tcctgctgtg ctgcatgacc     3660

agctgttgca gctgtctgaa gggcgcctgt agctgtggct cctgctgcaa gttcgatgag     3720

gacgactctg agccagtgct gaaaggcgtg aagctgcact acacc                     3765


<210>  3
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type trS-protein sequence

<400>  3

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ala Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser 
    1145                 1150         


<210>  4
<211>  3456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type tr-S-protein sequence

<400>  4
atgtttatct ttctgctgtt tctgaccctg accagcggca gcgacctgga tagatgcacc       60

accttcgacg atgtgcaggc ccctaactac acccagcaca ccagctctat gcggggcgtg      120

tactaccccg acgagatttt cagaagcgac accctgtatc tgacccagga cctgttcctg      180

cctttctaca gcaacgtgac cggcttccac accatcaacc acaccttcgg caaccctgtg      240

atccccttca aggacggcat ctactttgcc gccaccgaga agtccaacgt cgtcagagga      300

tgggtgttcg gcagcaccat gaacaacaag agccagagcg tgatcatcat caacaacagc      360

accaacgtgg tcatccgggc ctgcaacttc gagctgtgcg acaacccatt cttcgccgtg      420

tccaagccta tgggcaccca gacacacacc atgatcttcg acaacgcctt caactgcacc      480

ttcgagtaca tcagcgacgc cttcagcctg gacgtgtccg aaaagagcgg caacttcaag      540

cacctgaggg aattcgtgtt caagaacaag gatggcttcc tgtacgtgta caagggctac      600

cagcctatcg acgtcgtgcg ggatctgccc agcggcttca ataccctgaa gcctatcttc      660

aagctgcccc tgggcatcaa catcaccaac ttcagagcca tcctgaccgc tttcagcccc      720

gctcaggata tctggggaac aagcgccgct gcctacttcg tgggctacct gaagccaacc      780

accttcatgc tgaagtacga cgagaacggc accatcaccg acgccgtgga ctgtagccaa      840

aatcctctgg ccgagctgaa gtgcagcgtg aagtccttcg agatcgacaa gggcatctac      900

cagaccagca atttcagagt ggtgccctcc ggggatgtcg tgcggttccc caacatcaca      960

aatctgtgcc ccttcggcga ggtgttcaac gccaccaagt ttccctctgt gtacgcctgg     1020

gagcgcaaaa agatcagcaa ctgcgtggcc gactacagcg tgctgtacaa ctccaccttc     1080

ttcagcacct tcaagtgcta cggcgtgtcc gccacaaagc tgaacgacct gtgcttctcc     1140

aacgtgtacg ccgacagctt cgtggtcaaa ggcgacgacg ttcggcagat tgcccctgga     1200

caaacaggcg tgatcgccga ttacaactac aagctgcctg acgacttcat gggctgcgtg     1260

ctggcctgga acaccagaaa catcgatgcc acctccaccg gcaactacaa ttacaagtac     1320

agatacctgc ggcacggcaa gctgcggcct ttcgagaggg atatcagcaa tgtgcctttt     1380

agccccgacg gcaagccctg cacacctcct gctctgaatt gctactggcc cctgaacgac     1440

tacggctttt acaccaccac aggcatcggc tatcagccct atagagtggt ggtcctgtcc     1500

tttgagctgc tgaatgcccc tgccacagtg tgcggaccta agctgtctac cgacctgatc     1560

aagaaccagt gcgtgaactt caacttcaac ggcctgaccg gcaccggcgt gctgacacca     1620

agcagcaaga gattccagcc tttccagcag ttcggccggg atgtgtccga cttcacagac     1680

agcgtcagag atcccaagac cagcgagatc ctggacatca gcccttgtgc ctttggcgga     1740

gtgtccgtga tcacccctgg cacaaatgcc tctagcgaag tggccgtgct gtatcaggac     1800

gtgaactgca ccgatgtgtc caccgccatt cacgccgatc agctgactcc cgcttggcgg     1860

atctatagca caggcaacaa cgtgttccag acacaagccg gctgtctgat cggagccgag     1920

catgtggata ccagctacga gtgcgacatc cctatcggcg ctggcatctg tgcctcttac     1980

cacaccgtgt ctctgctgcg gagcaccagc cagaaatcca tcgtggccta caccatgagc     2040

ctgggcgccg attcttctat cgcctactcc aacaacacaa tcgctatccc caccaatttc     2100

agcatctcca tcaccaccga agtgatgccc gtgtccatgg ccaagacctc cgtggattgc     2160

aacatgtaca tctgcggcga cagcaccgag tgcgccaatc tgctgctcca gtacggcagc     2220

ttctgcaccc agctgaatag agccctgtct ggaattgccg ccgagcagga cagaaacacc     2280

agagaagtgt tcgcccaagt gaagcagatg tataagaccc cgacactcaa gtacttcggc     2340

gggttcaact tctcccagat cctgcctgat cctctgaagc ccaccaagcg gagcttcatc     2400

gaggacctgc tgttcaacaa agtgaccctg gccgacgccg gctttatgaa gcagtatggc     2460

gagtgcctgg gcgacatcaa cgccagggat ctgatttgcg cccagaagtt taacggactg     2520

accgtgctgc ctcctctgct gaccgatgat atgatcgccg cctacacagc cgctctggtg     2580

tctggtacag ctaccgccgg atggacattt ggagctggcg ccgctctcca gattccattc     2640

gctatgcaga tggcctaccg gttcaacggc atcggagtga cccagaatgt gctgtacgag     2700

aatcagaagc agatcgccaa tcagttcaac aaggccatca gccagatcca agagagcctg     2760

accaccacaa gcacagccct gggaaagctc caggacgtgg tcaaccagaa tgctcaggcc     2820

ctgaacaccc tggtcaagca gctgagcagc aacttcggcg ccatcagctc cgtgctgaat     2880

gacatcctga gccggctgga caaggtggaa gcagaggtgc agatcgaccg gctgatcaca     2940

ggcagactcc agagcctcca gacctacgtg acacagcagc tgatcagagc cgccgagatt     3000

agagcctctg ccaatctggc cgccaccaaa atgagcgagt gtgtcctggg ccagagcaag     3060

agagtggact tttgcggcaa gggctatcac ctgatgagct tcccacaggc cgctcctcat     3120

ggcgtggtct ttctgcacgt gacatacgtg cccagccaag agagaaactt caccaccgct     3180

ccagccatct gccacgaggg caaagcctac tttcccagag aaggcgtgtt cgtgtttaac     3240

ggcacctcct ggtttatcac ccagcggaat ttcttcagcc cgcaaatcat caccacagac     3300

aacaccttcg tgtccggcaa ctgtgacgtc gtgatcggca tcattaacaa taccgtgtac     3360

gaccctctcc agcctgagct ggacagcttc aaagaggaac tggataagta cttcaagaat     3420

cacacgagcc ccgatgtgga cctgggcgat atctct                               3456


<210>  5
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein RBD sequence

<400>  5

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp 
    210             


<210>  6
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein RBD sequence

<400>  6
agagtggtgc cctccgggga tgtcgtgcgg ttccccaaca tcacaaatct gtgccccttc       60

ggcgaggtgt tcaacgccac caagtttccc tctgtgtacg cctgggagcg caaaaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaactcca ccttcttcag caccttcaag      180

tgctacggcg tgtccgccac aaagctgaac gacctgtgct tctccaacgt gtacgccgac      240

agcttcgtgg tcaaaggcga cgacgttcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcctgacgac ttcatgggct gcgtgctggc ctggaacacc      360

agaaacatcg atgccacctc caccggcaac tacaattaca agtacagata cctgcggcac      420

ggcaagctgc ggcctttcga gagggatatc agcaatgtgc cttttagccc cgacggcaag      480

ccctgcacac ctcctgctct gaattgctac tggcccctga acgactacgg cttttacacc      540

accacaggca tcggctatca gccctataga gtggtggtcc tgtcctttga gctgctgaat      600

gcccctgcca cagtgtgcgg acctaagctg tctaccgac                             639


<210>  7
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein sequence

<400>  7

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  8
<211>  3819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein sequence

<400>  8
atgttcgtgt ttctggtgct gctgcctctg gtgtccagcc agtgtgtgaa cctgaccacc       60

agaacacagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gagattcgac      240

aaccccgtgc tgcccttcaa cgacggggtg tactttgcca gcaccgagaa gtccaacatc      300

atcagaggct ggatcttcgg caccacactg gacagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgggtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc ctttcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca cacccctatc aacctcgtgc gggatctgcc tcagggcttc      660

tctgctctgg aacccctggt ggatctgccc atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cctggcgata gcagcagcgg atggacagct      780

ggtgccgccg cttactacgt gggatacctc cagccaagaa ccttcctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctgg accctctgag cgagacaaag      900

tgcaccctga agtccttcac cgtggaaaag ggcatctacc agaccagcaa cttccgggtg      960

cagcccaccg aatccatcgt gcggttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccaccagatt cgcctctgtg tacgcctgga accggaagcg gatcagcaat     1080

tgcgtggccg actactccgt gctgtacaac tccgccagct tcagcacctt caagtgctac     1140

ggcgtgtccc ctaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgacagcttc     1200

gtgatccggg gagatgaagt gcggcagatt gcccctggac agacaggcaa gatcgccgac     1260

tacaactaca agctgcccga cgacttcacc ggctgtgtga ttgcctggaa cagcaacaac     1320

ctggactcca aagtcggcgg caactacaat tacctgtacc ggctgttccg gaagtccaat     1380

ctgaagccct tcgagcggga catcagcacc gaaatctatc aggccggcag caccccttgc     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcaaa gctacggctt tcagcccaca     1500

aatggcgtgg gctaccagcc ttacagagtg gtggtgctga gcttcgagct gctgcatgct     1560

cctgccacag tgtgcggccc taagaaatcc accaatctcg tgaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggcaccggc gtgctgacag agagcaacaa gaagttcctg     1680

ccattccagc agttcggccg ggatatcgcc gataccacag atgccgtcag agatccccag     1740

acactggaaa tcctggacat caccccatgc agcttcggcg gagtgtctgt gatcacccct     1800

ggcaccaaca ccagcaatca ggtggcagtg ctgtaccagg acgtgaactg taccgaagtg     1860

cccgtggcca ttcacgccga tcagctgaca cctacatggc gggtgtactc caccggcagc     1920

aatgtgtttc agaccagagc cggctgtctg atcggagccg agcacgtgaa caatagctac     1980

gagtgcgaca tccccatcgg cgctggcatc tgcgcctctt accagacaca gacaaacagc     2040

cccagacggg ctagaagcgt ggccagccag agcatcattg cctacacaat gtctctgggc     2100

gccgagaaca gcgtggccta ctccaacaac tctatcgcta tccccaccaa cttcaccatc     2160

agcgtgacca ccgagatcct gcctgtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gcgattccac cgagtgctcc aacctgctgc tccagtacgg cagcttctgc     2280

acccagctga atagagccct gacagggatc gccgtggaac aggacaagaa cacccaagag     2340

gtgttcgccc aagtgaagca aatctacaag acccctccta tcaaggactt cggcggcttc     2400

aatttcagcc agattctgcc cgatcctagc aagcccagca agcggagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggcttca tcaagcagta cggcgattgt     2520

ctgggcgaca ttgccgccag ggatctgatt tgcgcccaga agtttaacgg actgacagtg     2580

ctgcctcctc tgctgaccga tgagatgatc gcccagtaca catctgccct gctggccggc     2640

acaatcacaa gcggctggac atttggagct ggcgccgctc tccagattcc attcgctatg     2700

cagatggcct accggttcaa cggcatcgga gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga tccaggacag cctgagcagc     2820

acagcaagcg ccctgggaaa gctccaggac gtcgtgaacc agaatgccca ggcactgaac     2880

accctggtca agcagctgtc ctccaacttc ggcgccatca gctctgtgct gaacgatatc     2940

ctgagcagac tggacaaggt ggaagccgag gtgcagatcg acagactgat caccggcaga     3000

ctccagtctc tccagaccta cgtgacccag cagctgatca gagccgccga gattagagcc     3060

tctgccaatc tggccgccac caagatgtct gagtgtgtgc tgggccagag caagagagtg     3120

gacttttgcg gcaagggcta ccacctgatg agcttccctc agtctgcccc tcacggcgtg     3180

gtgtttctgc acgtgacata cgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggcaaagc ccactttcct agagaaggcg tgttcgtgtc caacggcacc     3300

cattggttcg tgacacagcg gaacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtgtctg gcaactgcga cgttgtgatc ggcattgtga acaataccgt gtacgaccct     3420

ctccagcctg aactggactc cttcaaagag gaactcgaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg cgatatcagc ggaatcaatg ccagcgtggt caacatccag     3540

aaagagatcg accggctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg ggaagtacga gcagtacatc aagtggccct ggtacatctg gctgggcttt     3660

atcgccggac tgattgccat cgtgatggtc acaatcatgc tgtgttgcat gaccagctgc     3720

tgtagctgcc tgaagggctg ttgtagctgt ggctcctgct gcaagttcga cgaggacgat     3780

tctgagcccg tgctgaaggg cgtgaaactg cactacacc                            3819


<210>  9
<211>  1170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type trS-protein sequence

<400>  9

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  
    1160                 1165                 1170 


<210>  10
<211>  3510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type trS-protein sequence

<400>  10
atgttcgtgt ttctggtgct gctgcctctg gtgtccagcc agtgtgtgaa cctgaccacc       60

agaacacagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gagattcgac      240

aaccccgtgc tgcccttcaa cgacggggtg tactttgcca gcaccgagaa gtccaacatc      300

atcagaggct ggatcttcgg caccacactg gacagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actaccacaa gaacaacaag agctggatgg aaagcgagtt ccgggtgtac      480

agcagcgcca acaactgcac cttcgagtac gtgtcccagc ctttcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaaaatct acagcaagca cacccctatc aacctcgtgc gggatctgcc tcagggcttc      660

tctgctctgg aacccctggt ggatctgccc atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cctggcgata gcagcagcgg atggacagct      780

ggtgccgccg cttactacgt gggatacctc cagccaagaa ccttcctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctgg accctctgag cgagacaaag      900

tgcaccctga agtccttcac cgtggaaaag ggcatctacc agaccagcaa cttccgggtg      960

cagcccaccg aatccatcgt gcggttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccaccagatt cgcctctgtg tacgcctgga accggaagcg gatcagcaat     1080

tgcgtggccg actactccgt gctgtacaac tccgccagct tcagcacctt caagtgctac     1140

ggcgtgtccc ctaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgacagcttc     1200

gtgatccggg gagatgaagt gcggcagatt gcccctggac agacaggcaa gatcgccgac     1260

tacaactaca agctgcccga cgacttcacc ggctgtgtga ttgcctggaa cagcaacaac     1320

ctggactcca aagtcggcgg caactacaat tacctgtacc ggctgttccg gaagtccaat     1380

ctgaagccct tcgagcggga catcagcacc gaaatctatc aggccggcag caccccttgc     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcaaa gctacggctt tcagcccaca     1500

aatggcgtgg gctaccagcc ttacagagtg gtggtgctga gcttcgagct gctgcatgct     1560

cctgccacag tgtgcggccc taagaaatcc accaatctcg tgaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggcaccggc gtgctgacag agagcaacaa gaagttcctg     1680

ccattccagc agttcggccg ggatatcgcc gataccacag atgccgtcag agatccccag     1740

acactggaaa tcctggacat caccccatgc agcttcggcg gagtgtctgt gatcacccct     1800

ggcaccaaca ccagcaatca ggtggcagtg ctgtaccagg acgtgaactg taccgaagtg     1860

cccgtggcca ttcacgccga tcagctgaca cctacatggc gggtgtactc caccggcagc     1920

aatgtgtttc agaccagagc cggctgtctg atcggagccg agcacgtgaa caatagctac     1980

gagtgcgaca tccccatcgg cgctggcatc tgcgcctctt accagacaca gacaaacagc     2040

cccagacggg ctagaagcgt ggccagccag agcatcattg cctacacaat gtctctgggc     2100

gccgagaaca gcgtggccta ctccaacaac tctatcgcta tccccaccaa cttcaccatc     2160

agcgtgacca ccgagatcct gcctgtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gcgattccac cgagtgctcc aacctgctgc tccagtacgg cagcttctgc     2280

acccagctga atagagccct gacagggatc gccgtggaac aggacaagaa cacccaagag     2340

gtgttcgccc aagtgaagca aatctacaag acccctccta tcaaggactt cggcggcttc     2400

aatttcagcc agattctgcc cgatcctagc aagcccagca agcggagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggcttca tcaagcagta cggcgattgt     2520

ctgggcgaca ttgccgccag ggatctgatt tgcgcccaga agtttaacgg actgacagtg     2580

ctgcctcctc tgctgaccga tgagatgatc gcccagtaca catctgccct gctggccggc     2640

acaatcacaa gcggctggac atttggagct ggcgccgctc tccagattcc attcgctatg     2700

cagatggcct accggttcaa cggcatcgga gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga tccaggacag cctgagcagc     2820

acagcaagcg ccctgggaaa gctccaggac gtcgtgaacc agaatgccca ggcactgaac     2880

accctggtca agcagctgtc ctccaacttc ggcgccatca gctctgtgct gaacgatatc     2940

ctgagcagac tggacaaggt ggaagccgag gtgcagatcg acagactgat caccggcaga     3000

ctccagtctc tccagaccta cgtgacccag cagctgatca gagccgccga gattagagcc     3060

tctgccaatc tggccgccac caagatgtct gagtgtgtgc tgggccagag caagagagtg     3120

gacttttgcg gcaagggcta ccacctgatg agcttccctc agtctgcccc tcacggcgtg     3180

gtgtttctgc acgtgacata cgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggcaaagc ccactttcct agagaaggcg tgttcgtgtc caacggcacc     3300

cattggttcg tgacacagcg gaacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtgtctg gcaactgcga cgttgtgatc ggcattgtga acaataccgt gtacgaccct     3420

ctccagcctg aactggactc cttcaaagag gaactcgaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg cgatatcagt                                      3510


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus wild-type S-protein RBD sequence

<400>  11

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  12
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD sequence

<400>  12
cgggtgcagc ccaccgaatc catcgtgcgg ttccccaata tcaccaatct gtgccccttc       60

ggcgaggtgt tcaatgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      120

agcaattgcg tggccgacta ctccgtgctg tacaactccg ccagcttcag caccttcaag      180

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcacaaacgt gtacgccgac      240

agcttcgtga tccggggaga tgaagtgcgg cagattgccc ctggacagac aggcaagatc      300

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgattgc ctggaacagc      360

aacaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      420

tccaatctga agcccttcga gcgggacatc agcaccgaaa tctatcaggc cggcagcacc      480

ccttgcaacg gcgtggaagg cttcaactgc tacttcccac tgcaaagcta cggctttcag      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tgctgagctt cgagctgctg      600

catgctcctg ccacagtgtg cggccctaag aaatccacca at                         642


<210>  13
<211>  1288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein designed sequence

<400>  13

Met Phe Leu Phe Leu Phe Ile Ile Ile Phe Ala Phe Phe Leu Leu Ser 
1               5                   10                  15      


Ala Lys Ala Asn Glu Arg Cys Gly Ile Phe Thr Ser Lys Pro Gln Pro 
            20                  25                  30          


Lys Leu Ala Gln Val Ser Ser Ser Arg Arg Gly Val Tyr Tyr Pro Asp 
        35                  40                  45              


Asp Ile Phe Arg Ser Asp Val Leu His Leu Thr Gln Asp Tyr Phe Leu 
    50                  55                  60                  


Pro Phe Asp Ser Asn Val Thr Arg Tyr Phe Ser Leu Asn Ala Asn Gly 
65                  70                  75                  80  


Pro Asp Arg Ile Val Tyr Phe Asp Asn Pro Ile Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Val Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Ile Arg Gly Trp 
            100                 105                 110         


Ile Phe Gly Ser Thr Leu Asp Asn Thr Ser Gln Ser Val Ile Ile Val 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Ile Ile Arg Val Cys Asn Phe Asp Leu Cys 
    130                 135                 140                 


Asn Asp Pro Phe Phe Thr Val Ser Arg Pro Thr Asp Lys His Ile Lys 
145                 150                 155                 160 


Thr Trp Ser Ile Arg Glu Phe Ala Val Tyr Gln Ser Ala Phe Asn Cys 
                165                 170                 175     


Thr Phe Glu Tyr Val Ser Lys Ser Phe Leu Leu Asp Val Ala Glu Lys 
            180                 185                 190         


Pro Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Val Asp 
        195                 200                 205             


Gly Phe Leu Asn Val Tyr Ser Thr Tyr Lys Pro Ile Asn Val Val Ser 
    210                 215                 220                 


Gly Leu Pro Thr Gly Phe Ser Val Leu Lys Pro Ile Leu Lys Leu Pro 
225                 230                 235                 240 


Leu Gly Ile Asn Ile Thr Ser Phe Arg Val Leu Leu Thr Met Phe Arg 
                245                 250                 255     


Gly Asp Pro Thr Pro Gly His Thr Thr Ala Asn Trp Leu Thr Ala Ala 
            260                 265                 270         


Ala Ala Tyr Tyr Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys 
        275                 280                 285             


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn 
    290                 295                 300                 


Pro Leu Ala Glu Leu Lys Cys Thr Leu Lys Asn Phe Asn Val Asp Lys 
305                 310                 315                 320 


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Ser Pro Thr Gln Glu Val 
                325                 330                 335     


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp Lys Val Phe 
            340                 345                 350         


Asn Ala Thr Arg Phe Pro Ser Val Tyr Ala Trp Glu Arg Thr Lys Ile 
        355                 360                 365             


Ser Asp Cys Val Ala Asp Tyr Thr Val Leu Tyr Asn Ser Thr Ser Phe 
    370                 375                 380                 


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Ser Lys Leu Ile Asp Leu 
385                 390                 395                 400 


Cys Phe Thr Ser Val Tyr Ala Asp Thr Phe Leu Ile Arg Cys Ser Glu 
                405                 410                 415     


Val Arg Gln Val Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn 
            420                 425                 430         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Thr 
        435                 440                 445             


Ala Lys Gln Asp Thr Gly Ser Ser Gly Asn Tyr Asn Tyr Tyr Tyr Arg 
    450                 455                 460                 


Ser His Arg Lys Thr Lys Leu Lys Pro Phe Glu Arg Asp Leu Ser Ser 
465                 470                 475                 480 


Asp Glu Cys Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Phe Asn 
                485                 490                 495     


Gly Val Arg Gly Phe Asn Cys Tyr Phe Thr Leu Ser Thr Tyr Asp Phe 
            500                 505                 510         


Asn Pro Asn Val Pro Val Glu Tyr Gln Ala Thr Arg Val Val Val Leu 
        515                 520                 525             


Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu 
    530                 535                 540                 


Ser Thr Gln Leu Val Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly 
545                 550                 555                 560 


Leu Lys Gly Thr Gly Val Leu Thr Ala Ser Ser Lys Arg Phe Gln Ser 
                565                 570                 575     


Phe Gln Gln Phe Gly Arg Asp Ala Ser Asp Phe Thr Asp Ser Val Arg 
            580                 585                 590         


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly 
        595                 600                 605             


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Ser Glu Val Ala 
    610                 615                 620                 


Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Pro Thr Ala Ile His 
625                 630                 635                 640 


Ala Asp Gln Leu Thr Pro Ala Trp Arg Val Tyr Ser Thr Gly Val Asn 
                645                 650                 655     


Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
            660                 665                 670         


Ala Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
        675                 680                 685             


Tyr His Thr Ala Ser Asn Ser Pro Arg Ile Leu Arg Ser Thr Gly Gln 
    690                 695                 700                 


Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Ile 
705                 710                 715                 720 


Ala Tyr Ala Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser 
                725                 730                 735     


Val Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp 
            740                 745                 750         


Cys Thr Met Tyr Ile Cys Gly Asp Ser Leu Glu Cys Ser Asn Leu Leu 
        755                 760                 765             


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
    770                 775                 780                 


Ile Ala Ile Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
785                 790                 795                 800 


Lys Gln Met Tyr Lys Thr Pro Ala Ile Lys Asp Phe Gly Gly Phe Asn 
                805                 810                 815     


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Thr Lys Arg Ser Phe 
            820                 825                 830         


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
        835                 840                 845             


Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Ser Ala Arg Asp Leu 
    850                 855                 860                 


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
865                 870                 875                 880 


Thr Asp Glu Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr 
                885                 890                 895     


Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
            900                 905                 910         


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
        915                 920                 925             


Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys 
    930                 935                 940                 


Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu 
945                 950                 955                 960 


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
                965                 970                 975     


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
            980                 985                 990         


Asn Asp Ile Leu Ser Arg Leu Asp  Lys Val Glu Ala Glu  Val Gln Ile 
        995                 1000                 1005             


Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
    1010                 1015                 1020             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1025                 1030                 1035             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1040                 1045                 1050             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1055                 1060                 1065             


Gln Ala  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1070                 1075                 1080             


Pro Ser  Gln Glu Arg Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1085                 1090                 1095             


Glu Gly  Lys Ala Tyr Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1100                 1105                 1110             


Gly Thr  Ser Trp Phe Ile Thr  Gln Arg Asn Phe Tyr  Ser Pro Gln 
    1115                 1120                 1125             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1130                 1135                 1140             


Val Ile  Gly Ile Ile Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1145                 1150                 1155             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1160                 1165                 1170             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1175                 1180                 1185             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1190                 1195                 1200             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1205                 1210                 1215             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Val Trp Leu 
    1220                 1225                 1230             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Ala  Thr Ile Leu 
    1235                 1240                 1245             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Ala Cys 
    1250                 1255                 1260             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1265                 1270                 1275             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1280                 1285             


<210>  14
<211>  3864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein designed sequence

<400>  14
atgtttctgt tcctcttcat tattatcttc gcattcttcc tgctgagcgc caaggccaac       60

gagagatgcg gcatcttcac cagcaagccc cagcctaagc tggcccaggt gtccagttct      120

agacggggcg tgtactaccc cgacgacatc ttcagatccg acgtgctgca tctgacccag      180

gactacttcc tgcctttcga cagcaacgtg acccggtact tcagcctgaa cgccaacgga      240

cccgaccgga tcgtgtactt cgacaaccct atcatcccct tcaaggacgg ggtgtacttt      300

gccgccaccg agaagtccaa cgtgatcaga ggctggatct tcggcagcac cctggacaat      360

accagccaga gcgtgatcat cgtgaacaac agcaccaacg tcatcatccg cgtgtgcaac      420

ttcgacctgt gcaacgaccc attcttcacc gtgtccagac caaccgacaa gcacatcaag      480

acctggtcca tccgcgagtt cgccgtgtac cagagcgcct tcaattgcac cttcgagtac      540

gtgtccaaga gctttctgct ggacgtggcc gagaagcccg gcaactttaa gcacctgaga      600

gaattcgtgt tcaagaacgt ggacggcttc ctgaacgtgt acagcaccta caagcccatc      660

aacgtggtgt ccggcctgcc tacaggattc agcgtgctga agcccatcct gaagctgccc      720

ctgggcatca acatcaccag cttcagagtg ctgctgacca tgttcagagg cgaccctaca      780

cctggccaca ccaccgctaa ttggctgaca gccgccgctg cctactacgt gggatacctg      840

aagcctacca ccttcatgct caagtacaac gagaacggca ccatcaccga cgccgtggac      900

tgtagccaaa atcctctggc cgagctgaag tgcaccctga agaacttcaa cgtggacaag      960

ggcatctacc agaccagcaa cttccgggtg tcccctacac aagaggtcgt gcggttcccc     1020

aatatcacca atctgtgccc cttcgacaag gtgttcaacg ccaccagatt tcccagcgtg     1080

tacgcctggg agcgcaccaa gatttccgat tgcgtggccg actacaccgt gctgtataac     1140

tccacctcct tcagcacctt caagtgctac ggcgtgtccc caagcaagct gatcgatctg     1200

tgcttcacct ctgtgtacgc cgacaccttc ctgatccggt gtagcgaagt gcgacaggtg     1260

gcacctggac agacaggcgt gatcgccgat tacaactaca agctgcccga cgacttcacc     1320

ggctgtgtga tcgcctggaa taccgccaag caggatacag gcagcagcgg caactacaac     1380

tactactaca gaagccaccg caagaccaag ctgaagcctt tcgagaggga cctgagcagc     1440

gacgagtgta gccctgatgg caagccttgt acacctcctg ccttcaatgg cgtgcggggc     1500

ttcaactgct acttcaccct gagcacctac gacttcaacc ccaacgtgcc cgtggaatac     1560

caggccacaa gagtggtggt gctgagcttc gagctgctga atgcccctgc cacagtgtgt     1620

ggccctaagc tgtctaccca gctggtcaag aaccagtgcg tgaacttcaa tttcaacggc     1680

ctgaaaggca ccggcgtgct gaccgccagc agcaagagat tccagagctt ccagcagttc     1740

ggcagggacg ccagcgattt cacagatagc gtcagagatc cccagacact ggaaatcctg     1800

gacatcagcc cttgcagctt cggcggagtg tctgtgatca cccctggcac caatacctct     1860

agcgaggtgg cagtgctgta ccaggacgtg aactgcaccg atgtgcctac agccatccac     1920

gccgatcagc tgacaccagc ttggagagtg tactctaccg gtgtcaacgt gttccagaca     1980

caagccggct gtctgattgg agccgaacac gtgaacgcca gctacgagtg cgacatccct     2040

atcggagccg gcatctgtgc ctcttaccac accgcctcta acagccccag aatcctgaga     2100

agcaccggcc agaaatccat cgtggcctac acaatgtctc tgggcgccga gaactctatc     2160

gcctacgcca acaactccat tgctatcccc accaacttca gcatctccgt gaccaccgaa     2220

gtgatgcctg tgtccatggc caagaccagc gtggactgca caatgtacat ctgcggcgac     2280

agcctggaat gcagcaacct gctgctccag tacggcagct tctgcaccca gctgaataga     2340

gccctgaccg gaatcgccat cgagcaggac aagaacaccc aagaggtgtt cgcccaagtg     2400

aagcagatgt ataagacccc tgccatcaag gacttcggcg gctttaactt cagccagatc     2460

ctgcctgatc ctagcaagcc caccaagcgg agcttcatcg aggacctgct gttcaacaaa     2520

gtgaccctgg ccgacgccgg ctttatgaag cagtatggcg agtgcctggg cgacatctct     2580

gccagggatc tgatttgcgc ccagaagttc aacggactga ccgtgctgcc tcctctgctg     2640

accgatgaga tgatcgccgc ctatacagcc gctctggtgt ctggcacagc taccgccgga     2700

tggacatttg gagctggcgc cgctctccag attccattcg ctatgcagat ggcctaccgc     2760

ttcaacggca tcggcgtgac ccagaacgtg ctgtacgaga accagaagca gatcgccaac     2820

cagttcaaca aggccatcag tcagatccaa gagagcctga ccacaaccag cacagccctg     2880

ggaaagctcc aggacgtcgt gaaccagaat gcccaggctc tgaacaccct ggtcaagcag     2940

ctgagcagca atttcggcgc catcagctcc gtgctgaacg acatcctgag ccggctggat     3000

aaggtggaag ccgaggtgca gatcgaccgg ctgattacag gcagactcca gtctctccag     3060

acctacgtga cacagcagct gatcagagcc gccgagatta gagcctctgc caatctggcc     3120

gccaccaaga tgtctgagtg tgtgctgggc cagtctaaga gagtggactt ctgcggcaag     3180

ggctaccacc tgatgagctt ccctcaggct gctcctcacg gcgtggtgtt tctgcacgtg     3240

acatacgtgc ccagccaaga gcggaacttc acaactgccc cagccatctg ccacgagggc     3300

aaagcctact ttcccagaga aggcgtgttc gtgtccaacg gcacctcctg gttcatcacc     3360

cagagaaact tctacagccc tcagatcatc accaccgaca acaccttcgt gtccggcaac     3420

tgcgacgtgg tcatcggcat catcaacaat accgtgtacg accctctcca gccagaactg     3480

gatagcttca aagaggaact cgacaagtac ttcaagaatc acacaagccc cgacgtggac     3540

ctgggcgata tcagcggaat caatgccagc gtggtcaaca tccagaaaga gatcgacaga     3600

ctgaacgagg tggccaagaa cctgaacgag tccctgatcg acctgcaaga gctggggaag     3660

tacgagcagt acatcaagtg gccttggtac gtgtggctgg gctttatcgc cggactgatc     3720

gccattgtga tggccaccat cctgctgtgc tgcatgacaa gctgctgtag ctgcctgaag     3780

ggcgcctgta gctgtggcag ctgctgcaag ttcgacgagg acgattctga gcctgtgctg     3840

aaaggcgtga agctgcacta cacc                                            3864


<210>  15
<211>  1185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus trS-protein designed sequence

<400>  15

Met Phe Leu Phe Leu Phe Ile Ile Ile Phe Ala Phe Phe Leu Leu Ser 
1               5                   10                  15      


Ala Lys Ala Asn Glu Arg Cys Gly Ile Phe Thr Ser Lys Pro Gln Pro 
            20                  25                  30          


Lys Leu Ala Gln Val Ser Ser Ser Arg Arg Gly Val Tyr Tyr Pro Asp 
        35                  40                  45              


Asp Ile Phe Arg Ser Asp Val Leu His Leu Thr Gln Asp Tyr Phe Leu 
    50                  55                  60                  


Pro Phe Asp Ser Asn Val Thr Arg Tyr Phe Ser Leu Asn Ala Asn Gly 
65                  70                  75                  80  


Pro Asp Arg Ile Val Tyr Phe Asp Asn Pro Ile Ile Pro Phe Lys Asp 
                85                  90                  95      


Gly Val Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Ile Arg Gly Trp 
            100                 105                 110         


Ile Phe Gly Ser Thr Leu Asp Asn Thr Ser Gln Ser Val Ile Ile Val 
        115                 120                 125             


Asn Asn Ser Thr Asn Val Ile Ile Arg Val Cys Asn Phe Asp Leu Cys 
    130                 135                 140                 


Asn Asp Pro Phe Phe Thr Val Ser Arg Pro Thr Asp Lys His Ile Lys 
145                 150                 155                 160 


Thr Trp Ser Ile Arg Glu Phe Ala Val Tyr Gln Ser Ala Phe Asn Cys 
                165                 170                 175     


Thr Phe Glu Tyr Val Ser Lys Ser Phe Leu Leu Asp Val Ala Glu Lys 
            180                 185                 190         


Pro Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Val Asp 
        195                 200                 205             


Gly Phe Leu Asn Val Tyr Ser Thr Tyr Lys Pro Ile Asn Val Val Ser 
    210                 215                 220                 


Gly Leu Pro Thr Gly Phe Ser Val Leu Lys Pro Ile Leu Lys Leu Pro 
225                 230                 235                 240 


Leu Gly Ile Asn Ile Thr Ser Phe Arg Val Leu Leu Thr Met Phe Arg 
                245                 250                 255     


Gly Asp Pro Thr Pro Gly His Thr Thr Ala Asn Trp Leu Thr Ala Ala 
            260                 265                 270         


Ala Ala Tyr Tyr Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys 
        275                 280                 285             


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn 
    290                 295                 300                 


Pro Leu Ala Glu Leu Lys Cys Thr Leu Lys Asn Phe Asn Val Asp Lys 
305                 310                 315                 320 


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Ser Pro Thr Gln Glu Val 
                325                 330                 335     


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp Lys Val Phe 
            340                 345                 350         


Asn Ala Thr Arg Phe Pro Ser Val Tyr Ala Trp Glu Arg Thr Lys Ile 
        355                 360                 365             


Ser Asp Cys Val Ala Asp Tyr Thr Val Leu Tyr Asn Ser Thr Ser Phe 
    370                 375                 380                 


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Ser Lys Leu Ile Asp Leu 
385                 390                 395                 400 


Cys Phe Thr Ser Val Tyr Ala Asp Thr Phe Leu Ile Arg Cys Ser Glu 
                405                 410                 415     


Val Arg Gln Val Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn 
            420                 425                 430         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Thr 
        435                 440                 445             


Ala Lys Gln Asp Thr Gly Ser Ser Gly Asn Tyr Asn Tyr Tyr Tyr Arg 
    450                 455                 460                 


Ser His Arg Lys Thr Lys Leu Lys Pro Phe Glu Arg Asp Leu Ser Ser 
465                 470                 475                 480 


Asp Glu Cys Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Phe Asn 
                485                 490                 495     


Gly Val Arg Gly Phe Asn Cys Tyr Phe Thr Leu Ser Thr Tyr Asp Phe 
            500                 505                 510         


Asn Pro Asn Val Pro Val Glu Tyr Gln Ala Thr Arg Val Val Val Leu 
        515                 520                 525             


Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu 
    530                 535                 540                 


Ser Thr Gln Leu Val Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly 
545                 550                 555                 560 


Leu Lys Gly Thr Gly Val Leu Thr Ala Ser Ser Lys Arg Phe Gln Ser 
                565                 570                 575     


Phe Gln Gln Phe Gly Arg Asp Ala Ser Asp Phe Thr Asp Ser Val Arg 
            580                 585                 590         


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly 
        595                 600                 605             


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Ser Glu Val Ala 
    610                 615                 620                 


Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Pro Thr Ala Ile His 
625                 630                 635                 640 


Ala Asp Gln Leu Thr Pro Ala Trp Arg Val Tyr Ser Thr Gly Val Asn 
                645                 650                 655     


Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
            660                 665                 670         


Ala Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
        675                 680                 685             


Tyr His Thr Ala Ser Asn Ser Pro Arg Ile Leu Arg Ser Thr Gly Gln 
    690                 695                 700                 


Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Ile 
705                 710                 715                 720 


Ala Tyr Ala Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser 
                725                 730                 735     


Val Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp 
            740                 745                 750         


Cys Thr Met Tyr Ile Cys Gly Asp Ser Leu Glu Cys Ser Asn Leu Leu 
        755                 760                 765             


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
    770                 775                 780                 


Ile Ala Ile Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
785                 790                 795                 800 


Lys Gln Met Tyr Lys Thr Pro Ala Ile Lys Asp Phe Gly Gly Phe Asn 
                805                 810                 815     


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Thr Lys Arg Ser Phe 
            820                 825                 830         


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
        835                 840                 845             


Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Ser Ala Arg Asp Leu 
    850                 855                 860                 


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
865                 870                 875                 880 


Thr Asp Glu Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr 
                885                 890                 895     


Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
            900                 905                 910         


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
        915                 920                 925             


Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys 
    930                 935                 940                 


Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu 
945                 950                 955                 960 


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
                965                 970                 975     


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
            980                 985                 990         


Asn Asp Ile Leu Ser Arg Leu Asp  Lys Val Glu Ala Glu  Val Gln Ile 
        995                 1000                 1005             


Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
    1010                 1015                 1020             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1025                 1030                 1035             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1040                 1045                 1050             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1055                 1060                 1065             


Gln Ala  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1070                 1075                 1080             


Pro Ser  Gln Glu Arg Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1085                 1090                 1095             


Glu Gly  Lys Ala Tyr Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1100                 1105                 1110             


Gly Thr  Ser Trp Phe Ile Thr  Gln Arg Asn Phe Tyr  Ser Pro Gln 
    1115                 1120                 1125             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1130                 1135                 1140             


Val Ile  Gly Ile Ile Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1145                 1150                 1155             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1160                 1165                 1170             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  
    1175                 1180                 1185 


<210>  16
<211>  3555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus trS-protein designed sequence

<400>  16
atgtttctgt tcctcttcat tattatcttc gcattcttcc tgctgagcgc caaggccaac       60

gagagatgcg gcatcttcac cagcaagccc cagcctaagc tggcccaggt gtccagttct      120

agacggggcg tgtactaccc cgacgacatc ttcagatccg acgtgctgca tctgacccag      180

gactacttcc tgcctttcga cagcaacgtg acccggtact tcagcctgaa cgccaacgga      240

cccgaccgga tcgtgtactt cgacaaccct atcatcccct tcaaggacgg ggtgtacttt      300

gccgccaccg agaagtccaa cgtgatcaga ggctggatct tcggcagcac cctggacaat      360

accagccaga gcgtgatcat cgtgaacaac agcaccaacg tcatcatccg cgtgtgcaac      420

ttcgacctgt gcaacgaccc attcttcacc gtgtccagac caaccgacaa gcacatcaag      480

acctggtcca tccgcgagtt cgccgtgtac cagagcgcct tcaattgcac cttcgagtac      540

gtgtccaaga gctttctgct ggacgtggcc gagaagcccg gcaactttaa gcacctgaga      600

gaattcgtgt tcaagaacgt ggacggcttc ctgaacgtgt acagcaccta caagcccatc      660

aacgtggtgt ccggcctgcc tacaggattc agcgtgctga agcccatcct gaagctgccc      720

ctgggcatca acatcaccag cttcagagtg ctgctgacca tgttcagagg cgaccctaca      780

cctggccaca ccaccgctaa ttggctgaca gccgccgctg cctactacgt gggatacctg      840

aagcctacca ccttcatgct caagtacaac gagaacggca ccatcaccga cgccgtggac      900

tgtagccaaa atcctctggc cgagctgaag tgcaccctga agaacttcaa cgtggacaag      960

ggcatctacc agaccagcaa cttccgggtg tcccctacac aagaggtcgt gcggttcccc     1020

aatatcacca atctgtgccc cttcgacaag gtgttcaacg ccaccagatt tcccagcgtg     1080

tacgcctggg agcgcaccaa gatttccgat tgcgtggccg actacaccgt gctgtataac     1140

tccacctcct tcagcacctt caagtgctac ggcgtgtccc caagcaagct gatcgatctg     1200

tgcttcacct ctgtgtacgc cgacaccttc ctgatccggt gtagcgaagt gcgacaggtg     1260

gcacctggac agacaggcgt gatcgccgat tacaactaca agctgcccga cgacttcacc     1320

ggctgtgtga tcgcctggaa taccgccaag caggatacag gcagcagcgg caactacaac     1380

tactactaca gaagccaccg caagaccaag ctgaagcctt tcgagaggga cctgagcagc     1440

gacgagtgta gccctgatgg caagccttgt acacctcctg ccttcaatgg cgtgcggggc     1500

ttcaactgct acttcaccct gagcacctac gacttcaacc ccaacgtgcc cgtggaatac     1560

caggccacaa gagtggtggt gctgagcttc gagctgctga atgcccctgc cacagtgtgt     1620

ggccctaagc tgtctaccca gctggtcaag aaccagtgcg tgaacttcaa tttcaacggc     1680

ctgaaaggca ccggcgtgct gaccgccagc agcaagagat tccagagctt ccagcagttc     1740

ggcagggacg ccagcgattt cacagatagc gtcagagatc cccagacact ggaaatcctg     1800

gacatcagcc cttgcagctt cggcggagtg tctgtgatca cccctggcac caatacctct     1860

agcgaggtgg cagtgctgta ccaggacgtg aactgcaccg atgtgcctac agccatccac     1920

gccgatcagc tgacaccagc ttggagagtg tactctaccg gtgtcaacgt gttccagaca     1980

caagccggct gtctgattgg agccgaacac gtgaacgcca gctacgagtg cgacatccct     2040

atcggagccg gcatctgtgc ctcttaccac accgcctcta acagccccag aatcctgaga     2100

agcaccggcc agaaatccat cgtggcctac acaatgtctc tgggcgccga gaactctatc     2160

gcctacgcca acaactccat tgctatcccc accaacttca gcatctccgt gaccaccgaa     2220

gtgatgcctg tgtccatggc caagaccagc gtggactgca caatgtacat ctgcggcgac     2280

agcctggaat gcagcaacct gctgctccag tacggcagct tctgcaccca gctgaataga     2340

gccctgaccg gaatcgccat cgagcaggac aagaacaccc aagaggtgtt cgcccaagtg     2400

aagcagatgt ataagacccc tgccatcaag gacttcggcg gctttaactt cagccagatc     2460

ctgcctgatc ctagcaagcc caccaagcgg agcttcatcg aggacctgct gttcaacaaa     2520

gtgaccctgg ccgacgccgg ctttatgaag cagtatggcg agtgcctggg cgacatctct     2580

gccagggatc tgatttgcgc ccagaagttc aacggactga ccgtgctgcc tcctctgctg     2640

accgatgaga tgatcgccgc ctatacagcc gctctggtgt ctggcacagc taccgccgga     2700

tggacatttg gagctggcgc cgctctccag attccattcg ctatgcagat ggcctaccgc     2760

ttcaacggca tcggcgtgac ccagaacgtg ctgtacgaga accagaagca gatcgccaac     2820

cagttcaaca aggccatcag tcagatccaa gagagcctga ccacaaccag cacagccctg     2880

ggaaagctcc aggacgtcgt gaaccagaat gcccaggctc tgaacaccct ggtcaagcag     2940

ctgagcagca atttcggcgc catcagctcc gtgctgaacg acatcctgag ccggctggat     3000

aaggtggaag ccgaggtgca gatcgaccgg ctgattacag gcagactcca gtctctccag     3060

acctacgtga cacagcagct gatcagagcc gccgagatta gagcctctgc caatctggcc     3120

gccaccaaga tgtctgagtg tgtgctgggc cagtctaaga gagtggactt ctgcggcaag     3180

ggctaccacc tgatgagctt ccctcaggct gctcctcacg gcgtggtgtt tctgcacgtg     3240

acatacgtgc ccagccaaga gcggaacttc acaactgccc cagccatctg ccacgagggc     3300

aaagcctact ttcccagaga aggcgtgttc gtgtccaacg gcacctcctg gttcatcacc     3360

cagagaaact tctacagccc tcagatcatc accaccgaca acaccttcgt gtccggcaac     3420

tgcgacgtgg tcatcggcat catcaacaat accgtgtacg accctctcca gccagaactg     3480

gatagcttca aagaggaact cgacaagtac ttcaagaatc acacaagccc cgacgtggac     3540

ctgggcgata tcagt                                                      3555


<210>  17
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  17

Arg Val Ser Pro Thr Gln Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Lys Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Thr Lys Ile Ser Asp Cys Val Ala Asp Tyr Thr 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
65                  70                  75                  80  


Thr Phe Leu Ile Arg Cys Ser Glu Val Arg Gln Val Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Thr Gly Ser Ser 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Tyr Tyr Arg Ser His Arg Lys Thr Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Leu Ser Ser Asp Glu Cys Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Phe Asn Gly Val Arg Gly Phe Asn Cys Tyr 
                165                 170                 175     


Phe Thr Leu Ser Thr Tyr Asp Phe Asn Pro Asn Val Pro Val Glu Tyr 
            180                 185                 190         


Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro 
        195                 200                 205             


Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Gln 
    210                 215                 


<210>  18
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  18
cgggtgtccc ctacacaaga ggtcgtgcgg ttccccaata tcaccaatct gtgccccttc       60

gacaaggtgt tcaacgccac cagatttccc agcgtgtacg cctgggagcg caccaagatt      120

tccgattgcg tggccgacta caccgtgctg tataactcca cctccttcag caccttcaag      180

tgctacggcg tgtccccaag caagctgatc gatctgtgct tcacctctgt gtacgccgac      240

accttcctga tccggtgtag cgaagtgcga caggtggcac ctggacagac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaatacc      360

gccaagcagg atacaggcag cagcggcaac tacaactact actacagaag ccaccgcaag      420

accaagctga agcctttcga gagggacctg agcagcgacg agtgtagccc tgatggcaag      480

ccttgtacac ctcctgcctt caatggcgtg cggggcttca actgctactt caccctgagc      540

acctacgact tcaaccccaa cgtgcccgtg gaataccagg ccacaagagt ggtggtgctg      600

agcttcgagc tgctgaatgc ccctgccaca gtgtgtggcc ctaagctgtc tacccag         657


<210>  19
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC Multiple Cloning Site sequence

<400>  19
acagactgtt cctttccatg ggtcttttct gcagtcaccg tcggtaccgt cgacacgtgt       60

gatcatctag aggatccgcg gccgcagatc t                                      91


<210>  20
<211>  4405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC sequence

<400>  20
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcggtaccgt cgacacgtgt gatcatctag aggatccgcg     1380

gccgcagatc tgctgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     1440

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     1500

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     1560

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggcta     1620

cccaggtgct gaagaattga cccggttcct cctgggccag aaagaagcag gcacatcccc     1680

ttctctgtga cacaccctgt ccacgcccct ggttcttagt tccagcccca ctcataggac     1740

actcatagct caggagggct ccgccttcaa tcccacccgc taaagtactt ggagcggtct     1800

ctccctccct catcagccca ccaaaccaaa cctagcctcc aagagtggga agaaattaaa     1860

gcaagatagg ctattaagtg cagagggaga gaaaatgcct ccaacatgtg aggaagtaat     1920

gagagaaatc atagaatttt aaggccatga tttaaggcca tcatggcctt aatcttccgc     1980

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     2040

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     2100

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     2160

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     2220

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     2280

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     2340

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     2400

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     2460

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     2520

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     2580

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     2640

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     2700

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     2760

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     2820

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     2880

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     2940

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactcgggg ggggggggcg     3000

ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc     3060

atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtt     3120

ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat     3180

ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc     3240

agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg     3300

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa     3360

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc     3420

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg     3480

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat     3540

ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca     3600

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga     3660

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg     3720

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg     3780

aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata     3840

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca     3900

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg     3960

ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat     4020

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt     4080

tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc agacagtttt     4140

attgttcatg atgatatatt tttatcttgt gcaatgtaac atcagagatt ttgagacaca     4200

acgtggcttt cccccccccc ccattattga agcatttatc agggttattg tctcatgagc     4260

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     4320

cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat     4380

aggcgtatca cgaggccctt tcgtc                                           4405


<210>  21
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS envelope protein sequence

<400>  21

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Thr Val Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Glu Gly Val Pro Asp Leu Leu Val 
65                  70                  75      


<210>  22
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus envelope protein designed sequence

<400>  22

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Thr Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Gln Gly Val Pro Asp Leu Leu Val 
65                  70                  75      


<210>  23
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus envelope protein designed sequence

<400>  23

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Thr Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Arg Val Pro Asp Leu Leu Val 
65                  70                  75  


<210>  24
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus M protein designed sequence

<400>  24

Met Ala Asp Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Gln Leu Leu 
1               5                   10                  15      


Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Ala Trp Ile Met 
            20                  25                  30          


Leu Leu Gln Phe Ala Tyr Ser Asn Arg Asn Arg Phe Leu Tyr Ile Ile 
        35                  40                  45              


Lys Leu Val Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys Phe 
    50                  55                  60                  


Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Val Thr Gly Gly Ile Ala 
65                  70                  75                  80  


Ile Ala Met Ala Cys Ile Val Gly Leu Met Trp Leu Ser Tyr Phe Val 
                85                  90                  95      


Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe Asn 
            100                 105                 110         


Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu Arg Gly Thr Ile Leu 
        115                 120                 125             


Thr Arg Pro Leu Met Glu Ser Glu Leu Val Ile Gly Ala Val Ile Ile 
    130                 135                 140                 


Arg Gly His Leu Arg Met Ala Gly His Ser Leu Gly Arg Cys Asp Ile 
145                 150                 155                 160 


Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser 
                165                 170                 175     


Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Gly Thr Asp Ser Gly Phe 
            180                 185                 190         


Ala Ala Tyr Asn Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp 
        195                 200                 205             


His Ala Gly Ser Asn Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220     


<210>  25
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus M protein designed sequence

<400>  25

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile 
            20                  25                  30          


Cys Leu Leu Gln Phe Ala Tyr Ser Asn Arg Asn Arg Phe Leu Tyr Ile 
        35                  40                  45              


Ile Lys Leu Ile Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys 
    50                  55                  60                  


Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Val Thr Gly Gly Ile 
65                  70                  75                  80  


Ala Ile Ala Met Ala Cys Ile Val Gly Leu Met Trp Leu Ser Tyr Phe 
                85                  90                  95      


Val Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe 
            100                 105                 110         


Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu Arg Gly Ser Ile 
        115                 120                 125             


Ile Thr Arg Pro Leu Met Glu Ser Glu Leu Val Ile Gly Ala Val Ile 
    130                 135                 140                 


Leu Arg Gly His Leu Arg Met Ala Gly His Ser Leu Gly Arg Cys Asp 
145                 150                 155                 160 


Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu 
                165                 170                 175     


Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Ser Asp Ser Gly 
            180                 185                 190         


Phe Ala Val Tyr Asn Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr 
        195                 200                 205             


Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220         


<210>  26
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus M protein reference sequence

<400>  26

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile 
            20                  25                  30          


Cys Leu Leu Gln Phe Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile 
        35                  40                  45              


Ile Lys Leu Ile Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys 
    50                  55                  60                  


Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile 
65                  70                  75                  80  


Ala Ile Ala Met Ala Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe 
                85                  90                  95      


Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe 
            100                 105                 110         


Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile 
        115                 120                 125             


Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile 
    130                 135                 140                 


Leu Arg Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp 
145                 150                 155                 160 


Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu 
                165                 170                 175     


Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly 
            180                 185                 190         


Phe Ala Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr 
        195                 200                 205             


Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220         


<210>  27
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  27

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Leu Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  28
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  28

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Ile Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  29
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  29

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Leu Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  30
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  30

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Leu Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  31
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  31

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Ile Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Thr Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  32
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  32

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Leu Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Thr Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp 
    210                 


<210>  33
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence


<220>
<221>  MISC_FEATURE
<222>  (203)..(203)
<223>  Glycosylation site introduced at this residue

<400>  33

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Asn Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  34
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Glycosylation site deleted at this residue

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Glycosylation site deleted at this residue

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Glycosylation site introduced at this residue

<400>  34

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Gln Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  35
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence


<220>
<221>  MISC_FEATURE
<222>  (203)..(203)
<223>  Glycosylation site introduced at this residue

<400>  35

Arg Val Ser Pro Thr Gln Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Lys Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Thr Lys Ile Ser Asp Cys Val Ala Asp Tyr Thr 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
65                  70                  75                  80  


Thr Phe Leu Ile Arg Cys Ser Glu Val Arg Gln Val Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Thr Gly Ser Ser 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Tyr Tyr Arg Ser His Arg Lys Thr Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Leu Ser Ser Asp Glu Cys Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Phe Asn Gly Val Arg Gly Phe Asn Cys Tyr 
                165                 170                 175     


Phe Thr Leu Ser Thr Tyr Asp Phe Asn Pro Asn Val Pro Val Glu Tyr 
            180                 185                 190         


Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Asn 
        195                 200                 205             


Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Gln 
    210                 215                 


<210>  36
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Glycosylation site deleted at this residue

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Glycosylation site deleted at this residue

<400>  36

Arg Val Ser Pro Thr Gln Glu Val Val Arg Phe Pro Gln Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Lys Val Phe Gln Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Thr Lys Ile Ser Asp Cys Val Ala Asp Tyr Thr 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr Ser Val Tyr Ala Asp 
65                  70                  75                  80  


Thr Phe Leu Ile Arg Cys Ser Glu Val Arg Gln Val Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Ala Lys Gln Asp Thr Gly Ser Ser 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Tyr Tyr Arg Ser His Arg Lys Thr Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Leu Ser Ser Asp Glu Cys Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Phe Asn Gly Val Arg Gly Phe Asn Cys Tyr 
                165                 170                 175     


Phe Thr Leu Ser Thr Tyr Asp Phe Asn Pro Asn Val Pro Val Glu Tyr 
            180                 185                 190         


Gln Ala Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro 
        195                 200                 205             


Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Gln 
    210                 215                 


<210>  37
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  37
cgggtgcagc ccaccgaatc catcgtgcgg ttccccaata tcaccaatct gtgccccttc       60

ggcgaggtgt tcaatgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      120

agcaattgcg tggccgacta ctccgtgctg tacaactccg ccagcttcag caccttcaag      180

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcacaaacgt gtacgccgac      240

agcttcgtga tccggggaga tgaagtgcgg cagattgccc ctggacagac aggcaagatc      300

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgattgc ctggaacagc      360

aacaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      420

tccaatctga agcccttcga gcgggacatc agcaccgaaa tctatcaggc cggcagcacc      480

ccttgcaacg gcgtggaagg cttcaactgc tacttcccac tgcaaagcta cggctttcag      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tgctgagctt cgagctgctg      600

catgctaacg ccacagtgtg cggccctaag aaatccacca at                         642


<210>  38
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  38
cgggtgcagc ccaccgaatc catcgtgcgg ttcccccaga tcaccaatct gtgccccttc       60

ggcgaggtgt tccaggccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      120

agcaattgcg tggccgacta ctccgtgctg tacaactcca ccagcttcag caccttcaag      180

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcacaaacgt gtacgccgac      240

agcttcgtga tccggggaga tgaagtgcgg cagattgccc ctggacagac aggcaagatc      300

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgattgc ctggaacagc      360

aacaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      420

tccaatctga agcccttcga gcgggacatc agcaccgaaa tctatcaggc cggcagcacc      480

ccttgcaacg gcgtggaagg cttcaactgc tacttcccac tgcaaagcta cggctttcag      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tgctgagctt cgagctgctg      600

catgctcctg ccacagtgtg cggccctaag aaatccacca at                         642


<210>  39
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  39
cgggtgtccc ctacacaaga ggtcgtgcgg ttccccaata tcaccaatct gtgccccttc       60

gacaaggtgt tcaacgccac cagatttccc agcgtgtacg cctgggagcg caccaagatt      120

tccgattgcg tggccgacta caccgtgctg tataactcca cctccttcag caccttcaag      180

tgctacggcg tgtccccaag caagctgatc gatctgtgct tcacctctgt gtacgccgac      240

accttcctga tccggtgtag cgaagtgcga caggtggcac ctggacagac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaatacc      360

gccaagcagg atacaggcag cagcggcaac tacaactact actacagaag ccaccgcaag      420

accaagctga agcctttcga gagggacctg agcagcgacg agtgtagccc tgatggcaag      480

ccttgtacac ctcctgcctt caatggcgtg cggggcttca actgctactt caccctgagc      540

acctacgact tcaaccccaa cgtgcccgtg gaataccagg ccacaagagt ggtggtgctg      600

agcttcgagc tgctgaatgc caacgccaca gtgtgtggcc ctaagctgtc tacccag         657


<210>  40
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed sequence

<400>  40
cgggtgtccc ctacacaaga ggtcgtgcgg ttcccccaga tcaccaatct gtgccccttc       60

gacaaggtgt tccaggccac cagatttccc agcgtgtacg cctgggagcg caccaagatt      120

tccgattgcg tggccgacta caccgtgctg tataactcca cctccttcag caccttcaag      180

tgctacggcg tgtccccaag caagctgatc gatctgtgct tcacctctgt gtacgccgac      240

accttcctga tccggtgtag cgaagtgcga caggtggcac ctggacagac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaatacc      360

gccaagcagg atacaggcag cagcggcaac tacaactact actacagaag ccaccgcaag      420

accaagctga agcctttcga gagggacctg agcagcgacg agtgtagccc tgatggcaag      480

ccttgtacac ctcctgcctt caatggcgtg cggggcttca actgctactt caccctgagc      540

acctacgact tcaaccccaa cgtgcccgtg gaataccagg ccacaagagt ggtggtgctg      600

agcttcgagc tgctgaatgc ccctgccaca gtgtgtggcc ctaagctgtc tacccag         657


<210>  41
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS2 envelope protein reference sequence

<400>  41

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Ser Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Arg Val Pro Asp Leu Leu Val 
65                  70                  75  


<210>  42
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus envelope protein designed sequence

<400>  42

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Ala Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Ser Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Arg Val Pro Asp Leu Leu Val 
65                  70                  75  


<210>  43
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus envelope protein designed sequence

<400>  43

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Ala Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Thr Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Gln Gly Val Pro Asp Leu Leu Val 
65                  70                  75      


<210>  44
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus envelope protein designed sequence

<400>  44

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Ala Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Thr Phe Tyr Val Tyr Ser Arg Val Lys Asn 
    50                  55                  60                  


Leu Asn Ser Ser Arg Val Pro Asp Leu Leu Val 
65                  70                  75  


<210>  45
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus nucleoprotein reference sequence

<400>  45

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210>  46
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus nucleoprotein designed sequence

<400>  46

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Ser Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Asp Asn Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Pro Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Arg Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Gly Lys 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Val Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Glu Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Ala Leu Pro Tyr Gly Ala Asn Lys Glu 
        115                 120                 125             


Gly Ile Val Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Asn Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Gly 
            180                 185                 190         


Asn Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Ser Gly Gly Gly Asp Thr Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Val Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Gln Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Glu 
305                 310                 315                 320 


Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr His Gly Ala Ile Lys Leu 
                325                 330                 335     


Asp Asp Lys Asp Pro Gln Phe Lys Asp Asn Val Ile Leu Leu Asn Lys 
            340                 345                 350         


His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp 
        355                 360                 365             


Lys Lys Lys Lys Ala Asp Glu Ala Gln Pro Leu Pro Gln Arg Gln Lys 
    370                 375                 380                 


Lys Gln Pro Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe 
385                 390                 395                 400 


Ser Lys Gln Leu Gln Asn Ser Met Ser Gly Ala Ser Ala Asp Ser Thr 
                405                 410                 415     


Gln Ala 
        


<210>  47
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus nucleoprotein designed sequence

<400>  47

Met Thr Asp Asn Gly Gln Gln Gly Pro Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Val Ser Asp Asn Phe Asp Asn Asn Gln Asp Gly Gly Arg Ser 
            20                  25                  30          


Gly Ala Arg Pro Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr 
        35                  40                  45              


Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Arg 
    50                  55                  60                  


Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp 
65                  70                  75                  80  


Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly 
                85                  90                  95      


Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu 
            100                 105                 110         


Gly Thr Gly Pro Glu Ala Ala Leu Pro Tyr Gly Ala Asn Lys Glu Gly 
        115                 120                 125             


Ile Val Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His 
    130                 135                 140                 


Ile Gly Thr Arg Asn Pro Asn Asn Asn Ala Ala Ile Val Leu Gln Leu 
145                 150                 155                 160 


Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg 
                165                 170                 175     


Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser 
            180                 185                 190         


Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg 
        195                 200                 205             


Asn Leu Gln Ala Gly Gly Asp Thr Ala Leu Ala Leu Leu Leu Leu Asp 
    210                 215                 220                 


Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln 
225                 230                 235                 240 


Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys 
                245                 250                 255     


Pro Arg Gln Lys Arg Thr Ala Thr Lys Gln Tyr Asn Val Thr Gln Ala 
            260                 265                 270         


Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln 
        275                 280                 285             


Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys Gln Trp Pro Gln Ile Ala 
    290                 295                 300                 


Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Glu Val 
305                 310                 315                 320 


Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp 
                325                 330                 335     


Asp Lys Asp Pro Gln Phe Lys Asp Asn Val Ile Leu Leu Asn Lys His 
            340                 345                 350         


Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys 
        355                 360                 365             


Lys Lys Lys Ala Asp Glu Ala Gln Pro Leu Pro Gln Arg Gln Lys Lys 
    370                 375                 380                 


Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser 
385                 390                 395                 400 


Arg Gln Leu Gln Asn Ser Met Ser Gly Ala Ser Ala Asp Ser Thr Gln 
                405                 410                 415     


Ala 
    


<210>  48
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus membrane protein designed sequence

<400>  48

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Ile Thr Gly Gly Ile Ala Ile Ala Met Ala Cys Leu Val 
            20                  25                  30          


Gly Leu Met Trp Leu Ser Tyr Phe Ile Ala Ser Phe Arg Leu Phe Ala 
        35                  40                  45              


Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu Thr Asn Ile Leu Leu 
    50                  55                  60                  


Asn Val Pro Leu His Gly Thr Ile Leu Thr Arg Pro Leu Leu Glu Ser 
65                  70                  75                  80  


Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly His Leu Arg Ile Ala 
                85                  90                  95      


Gly His His Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro Lys Glu Ile 
            100                 105                 110         


Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Leu Gly Ala Ser 
        115                 120                 125             


Gln Arg Val Ala Gly Asp Ser Gly Phe Ala Ala Tyr Ser Arg Tyr Arg 
    130                 135                 140                 


Ile Gly Asn Gly Lys Leu Asn Thr Asp His Ser Ser Ser Ser Asp Asn 
145                 150                 155                 160 


Ile Ala Leu Leu Val Gln 
                165     


<210>  49
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus membrane protein designed sequence

<400>  49

Met Ala Asp Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Gln Leu Leu 
1               5                   10                  15      


Glu Gln Val Thr Gly Gly Ile Ala Ile Ala Met Ala Cys Ile Val Gly 
            20                  25                  30          


Leu Met Trp Leu Ser Tyr Phe Val Ala Ser Phe Arg Leu Phe Ala Arg 
        35                  40                  45              


Thr Arg Ser Met Trp Ser Phe Asn Pro Glu Thr Asn Ile Leu Leu Asn 
    50                  55                  60                  


Val Pro Leu Arg Gly Thr Ile Leu Thr Arg Pro Leu Met Glu Ser Glu 
65                  70                  75                  80  


Leu Val Ile Gly Ala Val Ile Ile Arg Gly His Leu Arg Met Ala Gly 
                85                  90                  95      


His Ser Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro Lys Glu Ile Thr 
            100                 105                 110         


Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Leu Gly Ala Ser Gln 
        115                 120                 125             


Arg Val Gly Thr Asp Ser Gly Phe Ala Ala Tyr Asn Arg Tyr Arg Ile 
    130                 135                 140                 


Gly Asn Gly Lys Leu Asn Thr Asp His Ala Gly Ser Asn Asp Asn Ile 
145                 150                 155                 160 


Ala Leu Leu Val Gln 
                165 


<210>  50
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus membrane protein designed sequence

<400>  50

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Val Thr Gly Gly Ile Ala Ile Ala Met Ala Cys Ile Val 
            20                  25                  30          


Gly Leu Met Trp Leu Ser Tyr Phe Val Ala Ser Phe Arg Leu Phe Ala 
        35                  40                  45              


Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu Thr Asn Ile Leu Leu 
    50                  55                  60                  


Asn Val Pro Leu Arg Gly Ser Ile Ile Thr Arg Pro Leu Met Glu Ser 
65                  70                  75                  80  


Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly His Leu Arg Met Ala 
                85                  90                  95      


Gly His Ser Leu Gly Arg Cys Asp Ile Lys Asp Leu Pro Lys Glu Ile 
            100                 105                 110         


Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr Lys Leu Gly Ala Ser 
        115                 120                 125             


Gln Arg Val Ala Ser Asp Ser Gly Phe Ala Val Tyr Asn Arg Tyr Arg 
    130                 135                 140                 


Ile Gly Asn Gly Lys Leu Asn Thr Asp His Ser Ser Ser Ser Asp Asn 
145                 150                 155                 160 


Ile Ala Leu Leu Val Gln 
                165     


<210>  51
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein RBD designed protein

<400>  51

Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly Ala Val Phe 
1               5                   10                  15      


Val Ser Pro Ser Ala Ala Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
            20                  25                  30          


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
        35                  40                  45              


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
    50                  55                  60                  


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
65                  70                  75                  80  


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
                85                  90                  95      


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
            100                 105                 110         


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
        115                 120                 125             


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
    130                 135                 140                 


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
145                 150                 155                 160 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
                165                 170                 175     


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
            180                 185                 190         


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
        195                 200                 205             


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
    210                 215                 220                 


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Gly Gly Ser Gly 
225                 230                 235                 240 


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Ser 
                245                 250                 255     


His His His His His His 
            260         


<210>  52
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein mutant sequence

<400>  52

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  53
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus "Super_spike" S-protein designed sequence

<400>  53

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  54
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronavirus S-protein designed sequence

<400>  54

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Cys Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Cys Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  55
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Designed S protein RBD sequence COV_S_T2_19

<400>  55

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Leu Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ser Ser Ile Ala Ser 
225                 230                 235                 240 


Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
                245                 250                 255     


Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln 
            260                 265                 270         


Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        275                 280                 


<210>  56
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Designed S protein RBD sequence COV_S_T2_20

<400>  56

Arg Val Ala Pro Thr Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Thr Asn Asn Ile Asp Ser Thr Thr Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Ser Leu Arg Lys Ser Lys Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Ser Asp Ile Tyr Ser Pro Gly Gly Lys 
145                 150                 155                 160 


Pro Cys Ser Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Phe Pro Thr Asn Gly Thr Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Leu Ser Thr Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ser Ser Ile Ala Ser 
225                 230                 235                 240 


Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
                245                 250                 255     


Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln 
            260                 265                 270         


Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        275                 280                 


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_14 and Part of 
       discontinuous epitope of COV_S_T2_17

<400>  57

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
1               5                   10                  15      


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_14 and COV_S_T2_17

<400>  58

Lys Lys Ile Ser Asn 
1               5   


<210>  59
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_14 and COV_S_T2_17

<400>  59

Asn Ile 
1       


<210>  60
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_15 and COV_S_T2_18

<400>  60

Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
1               5                   10                  15      


Thr Lys Leu Asn Asp Leu Cys Phe Ser 
            20                  25  


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_15 and COV_S_T2_18

<400>  61

Asp Asp Phe Met 
1               


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_15 and COV_S_T2_18

<400>  62

Phe Glu Leu Leu Asn 
1               5   


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_16

<400>  63

Arg Gly Asp Glu Val Arg Gln 
1               5           


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_16

<400>  64

Thr Gly Lys Ile Ala Asp Tyr 
1               5           


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_16

<400>  65

Tyr Arg Leu Phe Arg Lys Ser Asn 
1               5               


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_16

<400>  66

Tyr Gln Ala Gly Ser Thr 
1               5       


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope of COV_S_T2_16

<400>  67

Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
1               5                   10                  15      


Gly Val Gly Tyr 
            20  


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  68

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  69

Lys Arg Ile Ser Asn 
1               5   


<210>  70
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  70

Asn Leu 
1       


<210>  71
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  71

Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
1               5                   10                  15      


Thr Lys Leu Asn Asp Leu Cys Phe Thr 
            20                  25  


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  72

Asp Asp Phe Thr 
1               


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  73

Thr Gly Val Ile Ala Asp Tyr 
1               5           


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  74

Tyr Arg Ser Leu Arg Lys Ser Lys 
1               5               


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  75

Tyr Ser Pro Gly Gly Lys 
1               5       


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  76

Phe Asn Cys Tyr Tyr Pro Leu Arg Ser Tyr Gly Phe Phe Pro Thr Asn 
1               5                   10                  15      


Gly Val Gly Tyr 
            20  


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of discontinuous epitope present in COV_S_T2_13

<400>  77

Phe Asn Cys Tyr Tyr Pro Leu Arg Ser Tyr Gly Phe Phe Pro Thr Asn 
1               5                   10                  15      


Gly Thr Gly Tyr 
            20  


<210>  78
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_13 encoding nucleic acid

<400>  78
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac cagatttccc tctgtgtacg cctgggagag aaagcggatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacctgg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  79
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_14 encoding nucleic acid

<400>  79
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac caagtttccc tctgtgtacg cctgggagcg caaaaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacatcg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  80
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_15 encoding nucleic acid

<400>  80
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac cagatttccc tctgtgtacg cctgggagag aaagcggatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccttcttcag cacctttaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcagcaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcatgggct gtgtgatcgc ctggaacacc      360

aacaacctgg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  81
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_16 encoding nucleic acid

<400>  81
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac cagatttccc tctgtgtacg cctgggagag aaagcggatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacagac aggcaagatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacctgg acagcaccac cggcggcaac tacaactacc tgtaccggct gttccggaag      420

tccaacctga agcctttcga gcgggacatc agcagcgaca tctatcaggc cggcagcaca      480

ccttgttctg gcgtggaagg cttcaactgc tacttcccac tgcaaagcta cggcttccag      540

cctaccaacg gcgtgggcta ccagccttat agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  82
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_17 encoding nucleic acid

<400>  82
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac caagtttccc tctgtgtacg cctgggagcg caaaaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacatcg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcacaggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  83
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_18 encoding nucleic acid

<400>  83
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac cagatttccc tctgtgtacg cctgggagag aaagcggatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccttcttcag cacctttaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcagcaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcatgggct gtgtgatcgc ctggaacacc      360

aacaacctgg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcacaggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctaccg ac                         642


<210>  84
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_19 encoding nucleic acid

<400>  84
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac cagatttccc tctgtgtacg cctgggagag aaagcggatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacctgg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctacag atggcggcgg aggatctggc      660

ggaggtggaa gcggaggcgg aggaagcggt ggcggcggat ctaaatcttc tatcgccagc      720

ttcttcttca tcatcggcct gattatcggc ctgttcctgg tgctgagagt gggcatccac      780

ctgtgcatca agctgaaaca caccaagaag cggcaaatct acaccgacat cgagatgaac      840

cggctgggca aa                                                          852


<210>  85
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV_S_T2_20 encoding nucleic acid

<400>  85
agagtggccc ctaccaaaga agtcgtgcgg ttccccaaca tcaccaatct gtgccctttc       60

ggcgaggtgt tcaacgccac caagtttccc tctgtgtacg cctgggagcg caaaaagatc      120

agcaactgcg tggccgacta cagcgtgctg tacaacagca ccagcttcag caccttcaag      180

tgctacggcg tgtcacccac caagctgaac gacctgtgct tcaccaacgt gtacgccgac      240

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacaaac aggcgtgatc      300

gccgattaca actacaagct gcccgacgac ttcaccggct gtgtgatcgc ctggaacacc      360

aacaacatcg acagcaccac cggcggcaac tacaactacc tgtacagaag cctgcggaag      420

tctaagctga agcccttcga gcgggacatc agcagcgaca tctatagccc tggcggcaag      480

ccttgttctg gcgtggaagg cttcaactgc tactaccctc tgcggagcta cggcttcttc      540

cccacaaatg gcacaggcta ccagccttac agagtggtgg tcctgagctt cgagctgctg      600

aatgcccctg ccacagtgtg tggccctaag ctgtctacag atggcggcgg aggatctggc      660

ggaggtggaa gcggaggcgg aggaagcggt ggcggcggat ctaaatcttc tatcgccagc      720

ttcttcttca tcatcggcct gattatcggc ctgttcctgg tgctgagagt gggcatccac      780

ctgtgcatca agctgaaaca caccaagaag cggcaaatct acaccgacat cgagatgaac      840

cggctgggca aa                                                          852


<210>  86
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS1 S protein

<400>  86

Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp 
1               5                   10                  15      


Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys Ser Ile Val 
        35                  40                  45              


Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn 
    50                  55                  60                  


Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu 
65                  70                  75                  80  


Val Met Pro Val Ser Met Ala Lys Thr Ser Val 
                85                  90      


<210>  87
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RaTG13 S protein

<400>  87

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
1               5                   10                  15      


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile Ile 
        35                  40                  45              


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn 
    50                  55                  60                  


Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu 
65                  70                  75                  80  


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                85                  90      


<210>  88
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPI_ISL_402119

<400>  88

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
1               5                   10                  15      


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        35                  40                  45              


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    50                  55                  60                  


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
65                  70                  75                  80  


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                85                  90                  95  


<210>  89
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPI_ISL_402132

<400>  89

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
1               5                   10                  15      


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        35                  40                  45              


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    50                  55                  60                  


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
65                  70                  75                  80  


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                85                  90                  95  


<210>  90
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPI_ISL_403936

<400>  90

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
1               5                   10                  15      


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        35                  40                  45              


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    50                  55                  60                  


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
65                  70                  75                  80  


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                85                  90                  95  


<210>  91
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPI_ISL_404253

<400>  91

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
1               5                   10                  15      


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        35                  40                  45              


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    50                  55                  60                  


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
65                  70                  75                  80  


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                85                  90                  95  


<210>  92
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus S protein

<400>  92

Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
1               5                   10                  15      


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            20                  25                  30          


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        35                  40                  45              


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    50                  55                  60                  


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
65                  70                  75                  80  


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                85                  90                  95  


<210>  93
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JQ765573_Human_coronavirus_NL63_Alpha E protein

<400>  93

Met Phe Leu Arg Leu Ile Asp Asp Asn Gly Ile Val Leu Asn Ser Ile 
1               5                   10                  15      


Leu Trp Leu Leu Val Met Ile Phe Phe Phe Val Leu Ala Met Thr Phe 
            20                  25                  30          


Ile Lys Leu Ile Gln Leu Cys Phe Thr Cys His Tyr Phe Phe Ser Arg 
        35                  40                  45              


Thr Leu Tyr Gln Pro Val Tyr Lys Ile Phe Leu Ala Tyr Gln Asp Tyr 
    50                  55                  60                  


Met Gln Ile Ala Pro Val Pro Ala Glu Val Leu Asn Val 
65                  70                  75          


<210>  94
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KF514430_Human_coronavirus_229E_Alpha E protein

<400>  94

Met Phe Leu Lys Leu Val Asp Asp His Ala Leu Val Val Asn Val Leu 
1               5                   10                  15      


Leu Trp Cys Val Val Leu Ile Val Ile Leu Leu Val Cys Ile Thr Ile 
            20                  25                  30          


Ile Lys Leu Ile Lys Leu Cys Phe Thr Cys His Met Phe Cys Asn Arg 
        35                  40                  45              


Thr Val Tyr Gly Pro Ile Lys Asn Val Tyr His Ile Tyr Gln Ser Tyr 
    50                  55                  60                  


Met His Ile Asp Pro Phe Pro Lys Arg Val Ile Asp Phe 
65                  70                  75          


<210>  95
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KF686340_Human_coronavirus_HKU1_Beta E protein

<400>  95

Met Val Asp Leu Phe Phe Asn Asp Thr Ala Trp Tyr Ile Gly Gln Ile 
1               5                   10                  15      


Leu Val Leu Val Leu Phe Cys Leu Ile Ser Leu Ile Phe Val Val Ala 
            20                  25                  30          


Phe Leu Ala Thr Ile Lys Leu Cys Met Gln Leu Cys Gly Phe Cys Asn 
        35                  40                  45              


Phe Phe Ile Ile Ser Pro Ser Ala Tyr Val Tyr Lys Arg Gly Met Gln 
    50                  55                  60                  


Leu Tyr Lys Ser Tyr Ser Glu Gln Val Ile Pro Pro Thr Ser Asp Tyr 
65                  70                  75                  80  


Leu Ile 
        


<210>  96
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MH940245_Human_coronavirus_HKU1_Beta E protein

<400>  96

Met Val Asp Val Phe Phe Thr Asp Thr Ala Trp Tyr Val Gly Gln Ile 
1               5                   10                  15      


Phe Phe Leu Val Leu Ser Cys Val Ile Phe Leu Ile Phe Val Val Ala 
            20                  25                  30          


Leu Leu Ala Thr Ile Lys Leu Cys Ile Gln Ile Cys Gly Phe Cys Asn 
        35                  40                  45              


Ile Phe Ile Ile Ser Pro Ser Ala Tyr Val Tyr Asn Arg Gly Arg Gln 
    50                  55                  60                  


Leu Tyr Lys Ser Tyr Ser Glu His Val Ile Pro Ser Thr Leu Asp Asp 
65                  70                  75                  80  


Leu Ile 
        


<210>  97
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KF600630_MERS_Beta E protein

<400>  97

Met Leu Pro Phe Val Gln Glu Arg Val Gly Leu Phe Ile Val Asn Phe 
1               5                   10                  15      


Phe Ile Phe Thr Val Val Cys Ala Ile Thr Leu Leu Val Cys Met Ala 
            20                  25                  30          


Phe Leu Thr Ala Thr Arg Leu Cys Val Gln Cys Met Thr Gly Phe Asn 
        35                  40                  45              


Thr Leu Leu Val Gln Pro Ala Leu Tyr Leu Tyr Asn Thr Gly Arg Ser 
    50                  55                  60                  


Val Tyr Val Lys Phe Gln Asp Ser Lys Pro Pro Leu Pro Pro Asp Glu 
65                  70                  75                  80  


Trp Val 
        


<210>  98
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus E protein

<400>  98

Met Leu Val Glu Thr Gly Leu Ile Val Asn Ser Leu Leu Leu Val Cys 
1               5                   10                  15      


Val Phe Leu Leu Val Ala Leu Thr Ala Ile Leu Cys Gln Cys Cys Phe 
            20                  25                  30          


Cys Asn Leu Val Pro Ser Ala Tyr Val Tyr Arg Gly Leu Tyr Ser Tyr 
        35                  40                  45              


Glu Ile Val Pro Pro Pro Pro Asp Leu Leu Val 
    50                  55                  


<210>  99
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus E protein

<400>  99

Met Phe Val Glu Thr Gly Ile Val Asn Leu Leu Leu Ala Cys Val Ile 
1               5                   10                  15      


Phe Leu Leu Val Ala Leu Thr Ala Arg Leu Cys Ala Gln Cys Cys Asn 
            20                  25                  30          


Val Leu Val Pro Ser Ala Tyr Val Tyr Arg Gly Leu Tyr Ser Tyr Ser 
        35                  40                  45              


Glu Val Ile Pro Pro Asp Leu Leu Val 
    50                  55          


<210>  100
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus E protein

<400>  100

Met Tyr Ser Phe Val Ser Glu Glu Thr Gly Thr Leu Ile Val Asn Ser 
1               5                   10                  15      


Val Leu Leu Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala 
            20                  25                  30          


Ile Leu Thr Ala Leu Arg Leu Cys Ala Tyr Cys Cys Asn Ile Val Asn 
        35                  40                  45              


Val Ser Leu Val Lys Pro Tyr Val Tyr Ser Arg Val Lys Asn Leu Asn 
    50                  55                  60                  


Ser Ser Gly Val Pro Asp Leu Leu Val 
65                  70              


<210>  101
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 M protein

<400>  101

Met Ala Asp Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Gln Leu Leu 
1               5                   10                  15      


Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Ala Trp Ile Met 
            20                  25                  30          


Met Leu Gln Phe Ala Tyr Ser Asn Arg Asn Arg Phe Leu Tyr Ile Ile 
        35                  40                  45              


Lys Leu Val Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys Phe 
    50                  55                  60                  


Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Val Thr Gly Gly Ile Ala 
65                  70                  75                  80  


Ile Ala Met Ala Cys Ile Val Gly Leu Met Trp Leu Ser Tyr Phe Val 
                85                  90                  95      


Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe Asn 
            100                 105                 110         


Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu Arg Gly Thr Ile Val 
        115                 120                 125             


Thr Arg Pro Leu Met Glu Ser Glu Leu Val Ile Gly Ala Val Ile Ile 
    130                 135                 140                 


Arg Gly His Leu Arg Met Ala Gly His Ser Leu Gly Arg Cys Asp Ile 
145                 150                 155                 160 


Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser 
                165                 170                 175     


Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Gly Thr Asp Ser Gly Phe 
            180                 185                 190         


Ala Ala Tyr Asn Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp 
        195                 200                 205             


His Ala Gly Ser Asn Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220     


<210>  102
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WIV16 S protein RBD

<400>  102

Arg Val Ala Pro Ser Lys Glu Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Thr Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Gln Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Ser Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Phe Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Ile Thr Asn Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp 
    210             


<210>  103
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RaTG13 S protein RBD

<400>  103

Arg Val Gln Pro Thr Asp Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Thr Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Thr Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Lys His Ile Asp Ala Lys Glu Gly 
        115                 120                 125             


Gly Asn Phe Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ala Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Gln Thr Gly Leu Asn Cys Tyr Tyr Pro Leu Tyr Arg 
                165                 170                 175     


Tyr Gly Phe Tyr Pro Thr Asp Gly Val Gly His Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  104
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N1 protein

<400>  104

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Cys Val Ala Asp Tyr 
        35                  40                  45              


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
    50                  55                  60                  


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
                85                  90                  95      


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
            100                 105                 110         


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
        115                 120                 125             


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
    130                 135                 140                 


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
145                 150                 155                 160 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Tyr Pro Leu Gln 
                165                 170                 175     


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
            180                 185                 190         


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
        195                 200                 205             


Gly Pro Lys Lys Ser Thr Asn 
    210                 215 


<210>  105
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-1 N protein

<400>  105

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Cys Val Ala Asp Tyr 
        35                  40                  45              


Ser Val Leu Tyr Asn Ser Thr Thr Phe Phe Ser Thr Phe Lys Cys Tyr 
    50                  55                  60                  


Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr 
65                  70                  75                  80  


Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro 
                85                  90                  95      


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            100                 105                 110         


Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr 
        115                 120                 125             


Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys 
    130                 135                 140                 


Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp 
145                 150                 155                 160 


Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn 
                165                 170                 175     


Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg 
            180                 185                 190         


Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys 
        195                 200                 205             


Gly Pro Lys Leu Ser Thr Asp 
    210                 215 


<210>  106
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPI_ISL_402119_RBD with C-terminal Lysine residue

<400>  106

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu 
    210                 215 


<210>  107
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS2 S protein X2

<400>  107

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Cys Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 

