                         SEQUENCE LISTING

<110>  DIOSynVax Ltd
       The Chancellor, Masters and Scholars of the University of 
       Cambridge
 
<120>  Influenza Vaccines

<130>  P/81947.WO01

<150>  GB 2004825.2
<151>  2020-04-01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 designed sequence

<400>  1

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  2
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5 designed sequence

<400>  2
atggaaaaga ttgtgctgct gctggccatc gtgtccctgg tcaagagcga tcaaatctgc       60

atcggctacc acgccaacaa cagcaccgaa caggtggaca ccattatgga aaagaacgtg      120

accgtgacac acgcccagga catcctggaa aagacccaca acggcaagct gtgcgacctg      180

gatggcgtga agcctctgat cctgagagat tgctctgtgg ccggctggct gctgggcaat      240

cctatgtgcg acgagttcat caacgtgccc gagtggtcct atatcgtgga aaaggccaat      300

cctgccaacg acctgtgcta ccccggcaac ttcaacgact acgaggaact gaaacatctg      360

ctgagccgga tcaaccactt cgagaagatc cagatcatcc ccaagtcctc ttggagcgat      420

cacgaggcct ctagcggagt gtctagcgcc tgtccttacc aaggcagaag cagcttcttc      480

cggaacgtcg tgtggctgat caagaagaac aacgcttacc ccaccatcaa gcggagctac      540

aacaacacca atcaagagga cctgctggtg ctgtggggca tccaccatcc taatgatgcc      600

gccgagcaga cccggctgta ccagaatcct acaacctaca tcagcgtggg caccagcaca      660

ctgaaccaga gactggtgcc taagatcgcc accagatcca aagtgaacgg ccagagcggc      720

cggatggaat tcttctggac catcctgaag cctaacgacg ccatcaactt cgagagcaac      780

ggcaacttta tcgcccctga gtacgcctac aagatcgtga agaagggcga cagcgccatc      840

atgaagtccg agctggaata cggcaactgc aacaccaagt gtcagacccc tatgggcgcc      900

atcaatagca gcatgccctt ccacaacatt caccctctga ccatcggcga gtgccccaaa      960

tacgtgaagt ccaacagact ggtcctggcc accggcctga gaaattctcc acagagagag     1020

cggcgcagaa agaagagagg cctgtttgga gccattgccg gctttatcga aggcggctgg     1080

caaggcatgg ttgacggatg gtacggctat caccacagca atgagcaagg ctctggctac     1140

gccgccgaca aagagagcac acagaaagcc atcgacggcg tgaccaacaa agtgaatagc     1200

atcatcgaca agatgaacac ccagttcgag gccgtgggca gagagttcaa caacctggaa     1260

agacggatcg agaacctgaa caagaagatg gaggacggct tcctggacgt gtggacctat     1320

aatgccgagc tgctggtcct gatggaaaac gagagaaccc tggacttcca cgacagcaac     1380

gtgaagaacc tgtacgacaa agtgcggctc cagctgcggg acaatgccaa agaactcggc     1440

aacggctgct tcgagttcta ccacaagtgc gacaacgagt gcatggaaag cgtgcggaac     1500

ggcacctacg actaccctca gtactctgag gaagcccggc tgaagagaga agagatcagc     1560

ggagtgaagc tggaatccat cggcacatac cagatcctga gcatctacag caccgtggcc     1620

tcttctctgg ccctggctat tatggtggct ggcctgagcc tgtggatgtg ctctaatggc     1680

agcctccagt gccggatctg catc                                            1704


<210>  3
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 Head region designed sequence

<400>  3

Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile 
1               5                   10                  15      


Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys 
            20                  25                  30          


Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala 
        35                  40                  45              


Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu 
    50                  55                  60                  


Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 
65                  70                  75                  80  


Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val 
                85                  90                  95      


Ser Ser Ala Cys Pro Tyr Gln Gly Arg Ser Ser Phe Phe Arg Asn Val 
            100                 105                 110         


Val Trp Leu Ile Lys Lys Asn Asn Ala Tyr Pro Thr Ile Lys Arg Ser 
        115                 120                 125             


Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His 
    130                 135                 140                 


His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr 
145                 150                 155                 160 


Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro 
                165                 170                 175     


Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 
            180                 185                 190         


Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser 
        195                 200                 205             


Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys 
    210                 215                 220                 


Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn 
225                 230                 235                 240 


Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe 
                245                 250                 255     


His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
            260                 265             


<210>  4
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5 Head region designed sequence

<400>  4
acccacaacg gcaagctgtg cgacctggat ggcgtgaagc ctctgatcct gagagattgc       60

tctgtggccg gctggctgct gggcaatcct atgtgcgacg agttcatcaa cgtgcccgag      120

tggtcctata tcgtggaaaa ggccaatcct gccaacgacc tgtgctaccc cggcaacttc      180

aacgactacg aggaactgaa acatctgctg agccggatca accacttcga gaagatccag      240

atcatcccca agtcctcttg gagcgatcac gaggcctcta gcggagtgtc tagcgcctgt      300

ccttaccaag gcagaagcag cttcttccgg aacgtcgtgt ggctgatcaa gaagaacaac      360

gcttacccca ccatcaagcg gagctacaac aacaccaatc aagaggacct gctggtgctg      420

tggggcatcc accatcctaa tgatgccgcc gagcagaccc ggctgtacca gaatcctaca      480

acctacatca gcgtgggcac cagcacactg aaccagagac tggtgcctaa gatcgccacc      540

agatccaaag tgaacggcca gagcggccgg atggaattct tctggaccat cctgaagcct      600

aacgacgcca tcaacttcga gagcaacggc aactttatcg cccctgagta cgcctacaag      660

atcgtgaaga agggcgacag cgccatcatg aagtccgagc tggaatacgg caactgcaac      720

accaagtgtc agacccctat gggcgccatc aatagcagca tgcccttcca caacattcac      780

cctctgacca tcggcgagtg cccc                                             804


<210>  5
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 Stem region designed sequence

<400>  5

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly 
    50                  55                  60                  


Leu Arg Asn Ser Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val 
                85                  90                  95      


Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr 
            100                 105                 110         


Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn 
        115                 120                 125             


Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val 
    130                 135                 140                 


Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys 
145                 150                 155                 160 


Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu 
                165                 170                 175     


Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn 
            180                 185                 190         


Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala 
        195                 200                 205             


Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn 
    210                 215                 220                 


Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr 
225                 230                 235                 240 


Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu 
                245                 250                 255     


Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala 
            260                 265                 270         


Ser Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met 
        275                 280                 285             


Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
    290                 295                 300 


<210>  6
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5 stem region designed sequence

<400>  6
atggaaaaga ttgtgctgct gctggccatc gtgtccctgg tcaagagcga tcaaatctgc       60

atcggctacc acgccaacaa cagcaccgaa caggtggaca ccattatgga aaagaacgtg      120

accgtgacac acgcccagga catcctggaa aagaaatacg tgaagtccaa cagactggtc      180

ctggccaccg gcctgagaaa ttctccacag agagagcggc gcagaaagaa gagaggcctg      240

tttggagcca ttgccggctt tatcgaaggc ggctggcaag gcatggttga cggatggtac      300

ggctatcacc acagcaatga gcaaggctct ggctacgccg ccgacaaaga gagcacacag      360

aaagccatcg acggcgtgac caacaaagtg aatagcatca tcgacaagat gaacacccag      420

ttcgaggccg tgggcagaga gttcaacaac ctggaaagac ggatcgagaa cctgaacaag      480

aagatggagg acggcttcct ggacgtgtgg acctataatg ccgagctgct ggtcctgatg      540

gaaaacgaga gaaccctgga cttccacgac agcaacgtga agaacctgta cgacaaagtg      600

cggctccagc tgcgggacaa tgccaaagaa ctcggcaacg gctgcttcga gttctaccac      660

aagtgcgaca acgagtgcat ggaaagcgtg cggaacggca cctacgacta ccctcagtac      720

tctgaggaag cccggctgaa gagagaagag atcagcggag tgaagctgga atccatcggc      780

acataccaga tcctgagcat ctacagcacc gtggcctctt ctctggccct ggctattatg      840

gtggctggcc tgagcctgtg gatgtgctct aatggcagcc tccagtgccg gatctgcatc      900


<210>  7
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 designed sequence

<400>  7

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asp Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  8
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 head region designed sequence

<400>  8

Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile 
1               5                   10                  15      


Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys 
            20                  25                  30          


Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala 
        35                  40                  45              


Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu 
    50                  55                  60                  


Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 
65                  70                  75                  80  


Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val 
                85                  90                  95      


Ser Ser Ala Cys Pro Tyr Gln Gly Arg Pro Ser Phe Phe Arg Asn Val 
            100                 105                 110         


Val Trp Leu Ile Lys Lys Asn Asp Thr Tyr Pro Thr Ile Lys Arg Ser 
        115                 120                 125             


Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His 
    130                 135                 140                 


His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr 
145                 150                 155                 160 


Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro 
                165                 170                 175     


Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 
            180                 185                 190         


Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser 
        195                 200                 205             


Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys 
    210                 215                 220                 


Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn 
225                 230                 235                 240 


Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe 
                245                 250                 255     


His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
            260                 265             


<210>  9
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 stem region designed sequence

<400>  9

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly 
    50                  55                  60                  


Leu Arg Asn Ser Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val 
                85                  90                  95      


Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr 
            100                 105                 110         


Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn 
        115                 120                 125             


Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val 
    130                 135                 140                 


Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys 
145                 150                 155                 160 


Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu 
                165                 170                 175     


Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn 
            180                 185                 190         


Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala 
        195                 200                 205             


Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn 
    210                 215                 220                 


Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr 
225                 230                 235                 240 


Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu 
                245                 250                 255     


Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala 
            260                 265                 270         


Ser Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met 
        275                 280                 285             


Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
    290                 295                 300 


<210>  10
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 designed sequence

<400>  10

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Arg Pro Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  11
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 head region designed sequence

<400>  11

Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile 
1               5                   10                  15      


Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys 
            20                  25                  30          


Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala 
        35                  40                  45              


Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Phe Asn Asp Tyr Glu 
    50                  55                  60                  


Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln 
65                  70                  75                  80  


Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val 
                85                  90                  95      


Ser Ser Ala Cys Pro Tyr Gln Gly Arg Pro Ser Phe Phe Arg Asn Val 
            100                 105                 110         


Val Trp Leu Ile Lys Lys Asn Asn Thr Tyr Pro Thr Ile Lys Arg Ser 
        115                 120                 125             


Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His 
    130                 135                 140                 


His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr 
145                 150                 155                 160 


Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro 
                165                 170                 175     


Lys Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu 
            180                 185                 190         


Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser 
        195                 200                 205             


Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys 
    210                 215                 220                 


Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn 
225                 230                 235                 240 


Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe 
                245                 250                 255     


His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro 
            260                 265             


<210>  12
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 stem region designed sequence

<400>  12

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly 
    50                  55                  60                  


Leu Arg Asn Ser Pro Gln Arg Glu Arg Arg Arg Lys Lys Arg Gly Leu 
65                  70                  75                  80  


Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val 
                85                  90                  95      


Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr 
            100                 105                 110         


Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn 
        115                 120                 125             


Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val 
    130                 135                 140                 


Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys 
145                 150                 155                 160 


Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu 
                165                 170                 175     


Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn 
            180                 185                 190         


Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala 
        195                 200                 205             


Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn 
    210                 215                 220                 


Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr 
225                 230                 235                 240 


Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu 
                245                 250                 255     


Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala 
            260                 265                 270         


Ser Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met 
        275                 280                 285             


Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
    290                 295                 300 


<210>  13
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5 head domain fragment designed sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Residue 2 is P or S

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Residue 16 is D or N

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Residue 17 is T or A

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Residue 50 is K or R

<400>  13

Arg Xaa Ser Phe Phe Arg Asn Val Val Trp Leu Ile Lys Lys Asn Xaa 
1               5                   10                  15      


Xaa Tyr Pro Thr Ile Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp 
            20                  25                  30          


Leu Leu Val Leu Trp Gly Ile His His Pro Asn Asp Ala Ala Glu Gln 
        35                  40                  45              


Thr Xaa 
    50 


<210>  14
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza M2 designed sequence

<400>  14

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Gly Trp Glu 
1               5                   10                  15      


Cys Arg Cys Ser Asp Ser Ser Asp Pro Leu Val Ile Ala Ala Ser Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Leu Lys Tyr Gly Leu Lys Arg Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Glu Ser Met Arg Glu Glu Tyr Arg Gln Lys Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Val Asp Asp Gly His Phe Val Asn Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  15
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza M2 designed sequence

<400>  15
atgtctctgc tgaccgaggt ggaaacccct accagaaatg gctgggagtg cagatgcagc       60

gacagcagcg atcctctggt tatcgccgcc agcatcatcg gcatcctgca cctgatcctg      120

tggatcctgg accggctgtt cttcaagtgc atctaccggc ggctgaagta cggcctgaag      180

agaggccctt ctacagaggg cgtgcccgag agcatgcggg aagagtacag acagaaacag      240

cagagcgccg tggacgtgga cgatggccac ttcgtgaaca tcgagctgga a               291


<210>  16
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza NA designed sequence

<400>  16

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Val Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Thr Gly Asn Gln Asn Gln Pro Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Ile Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Val Ala Glu Gln Ala Val 
65                  70                  75                  80  


Ala Ser Val Ala Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Ser Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Ile Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Val Lys Ser Val Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Lys Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Ser Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp 
    370                 375                 380                 


Ser Ser Phe Ser Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  17
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza NA designed sequence

<400>  17
atgaatccaa atcagaaaat aataaccatt gggtcaatct gtatggtagt tggaataatc       60

agcctaatat tacaaattgg gaacataatc tcaatatggg ttagccattc aattcagact      120

ggaaatcaaa accaacctga aacatgcaac caaagcatca ttacttatga aaacaacact      180

tgggtgaatc aaacatatgt taacatcagc aataccaatt ttgttgctga acaggctgta      240

gcttcagtgg cattagcggg caattcctct ctctgcccca ttagtgggtg ggctatatac      300

agcaaggaca atggcataag gattggttcc aagggagatg tatttgtcat aagagagcca      360

ttcatttcat gctcccactt ggaatgcagg accttttttc tgactcaagg agccttgttg      420

aatgacaaac attccaatgg aaccgttaaa gacagaagcc cctacagaac cttaatgagc      480

tgtcctgttg gtgaggctcc ctctccatac aattcaaggt ttgagtcggt tgcttggtca      540

gcaagtgctt gccatgatgg cattagctgg ttgacaattg gaatttccgg gccagacaat      600

ggggcagtgg ctgtattgaa atacaatggc ataataacag acactatcaa aagttggaga      660

aacaacatat tgaggacaca agagtctgaa tgtgcctgca taaatggttc ttgctttact      720

ataatgaccg atggaccaag taatgggcag gcctcataca agattttcaa gatagagaag      780

gggaaggtag tcaaatcagt cgagttgaat gcccctaatt accactacga ggaatgttcc      840

tgttatcctg atgctggcga agtaatgtgt gtgtgcaggg ataattggca tggttcgaat      900

cgaccatggg tgtctttcaa tcaaaatctg gagtatcaaa taggatacat atgcagtggg      960

gttttcggag acaatccacg ccccaatgat ggaacaggca gctgtggtcc agtgtcttct     1020

aatggagcat atggagtaaa gggattttca tttaagtacg gcaagggtgt ttggataggg     1080

agaactaaga gcactagttc caggagtgga tttgagatga tttgggatcc caatggatgg     1140

acagagacag atagtagttt ctcagtgaag caagatattg tagcaataac tgattggtca     1200

ggatatagcg ggagttttgt ccaacatcca gaattaacag ggctggactg catgaggcct     1260

tgcttctggg ttgaactaat cagaggacgg cctaaggaga acacaatctg gactagtggg     1320

agcagcattt ccttctgtgg tgtaaatagc gacactgtgg gttggtcttg gccagacggt     1380

gctgagttgc cattcaccat tgacaag                                         1407


<210>  18
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza NA designed sequence

<400>  18

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Val Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Thr Gly Asn Gln Asn His Pro Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Ile Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Val Val Ala Gly Gln Asp Ala 
65                  70                  75                  80  


Thr Ser Val Ile Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Lys Ile Glu Lys Gly Lys Val Ile Lys Ser Ile Glu Leu Asn Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys Val 
        275                 280                 285             


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Arg 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Ser Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp 
    370                 375                 380                 


Ser Ser Phe Ser Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Gln Pro Lys 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  19
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza NA designed sequence

<400>  19
atgaatccaa atcaaaaaat aataaccatt gggtcaatct gtatggtagt tggaataatt       60

agcctaatat tgcaaatagg gaatataatc tcaatatggg ttagccattc aattcaaact      120

ggaaatcaaa accatcctga aacatgcaac caaagcatca ttacctatga aaataacacc      180

tgggtgaatc aaacatatgt taacattagc aatactaacg ttgttgctgg acaggatgca      240

acttcagtga tattagccgg caattcctct ctttgcccca tcagtgggtg ggctatatac      300

agcaaagaca atggcataag aattggttcc aaaggagacg tttttgtcat aagagagcca      360

tttatttcat gctctcactt ggaatgcagg accttttttc tgactcaagg cgccttgctg      420

aatgacaagc attcaaatgg gaccgtcaag gacagaagcc cctatagaac cttaatgagc      480

tgccctgttg gtgaagctcc gtctccgtac aattcaaggt tcgaatcggt tgcttggtca      540

gcaagtgcat gccatgatgg catgggctgg ctaacaatcg gaatttccgg tccagataat      600

ggagcagtgg ctgtattaaa atacaatggt ataataacag acaccatcaa aagttggagg      660

aacaacatat tgagaacgca agagtctgaa tgtgcctgtg taaatggttc atgttttact      720

ataatgaccg atggcccaag taatgggcag gcctcgtaca aaattttcaa gatagagaag      780

gggaaggtta ttaaatcaat tgagttgaat gcacctaatt accactacga ggaatgttcc      840

tgttaccctg atacaggtaa agtgatgtgt gtgtgcagag acaattggca tggttcgaat      900

cgaccatggg tgtctttcga tcaaaatctg gattatcaaa taggatacat ctgcagtggg      960

gttttcggtg acaatccgcg tcccaatgat ggaacaggca gctgtggtcc agtgtcttct     1020

aatggagcaa atggagtaaa gggattttca tttaggtatg gtaatggtgt ttggatagga     1080

agaactaaaa gtaccagttc cagaagcggg tttgagatga tttgggatcc taatggatgg     1140

acagagactg atagtagttt ctctgtgaaa caagatattg tagcaataac tgattggtca     1200

gggtacagcg ggagtttcgt tcaacatcct gagctaacag ggctggactg catgaggcct     1260

tgcttctggg ttgaattaat caggggacaa cctaaagaga acacaatctg gactagtggg     1320

agcagcattt ccttttgtgg cgtaaatagt gatactgtag gttggtcttg gccagacggt     1380

gctgagttgc cattcaccat tgacaag                                         1407


<210>  20
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC Multiple Cloning Site sequence

<400>  20
acagactgtt cctttccatg ggtcttttct gcagtcaccg tcggtaccgt cgacacgtgt       60

gatcatctag aggatccgcg gccgcagatc t                                      91


<210>  21
<211>  4405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEVAC sequence

<400>  21
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcggtaccgt cgacacgtgt gatcatctag aggatccgcg     1380

gccgcagatc tgctgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     1440

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     1500

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     1560

agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggcta     1620

cccaggtgct gaagaattga cccggttcct cctgggccag aaagaagcag gcacatcccc     1680

ttctctgtga cacaccctgt ccacgcccct ggttcttagt tccagcccca ctcataggac     1740

actcatagct caggagggct ccgccttcaa tcccacccgc taaagtactt ggagcggtct     1800

ctccctccct catcagccca ccaaaccaaa cctagcctcc aagagtggga agaaattaaa     1860

gcaagatagg ctattaagtg cagagggaga gaaaatgcct ccaacatgtg aggaagtaat     1920

gagagaaatc atagaatttt aaggccatga tttaaggcca tcatggcctt aatcttccgc     1980

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     2040

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     2100

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     2160

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     2220

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     2280

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     2340

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     2400

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     2460

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     2520

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     2580

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     2640

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     2700

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     2760

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     2820

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     2880

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     2940

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactcgggg ggggggggcg     3000

ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc     3060

atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtt     3120

ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat     3180

ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc     3240

agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg     3300

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa     3360

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc     3420

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg     3480

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat     3540

ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca     3600

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga     3660

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg     3720

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg     3780

aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata     3840

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca     3900

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg     3960

ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat     4020

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt     4080

tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc agacagtttt     4140

attgttcatg atgatatatt tttatcttgt gcaatgtaac atcagagatt ttgagacaca     4200

acgtggcttt cccccccccc ccattattga agcatttatc agggttattg tctcatgagc     4260

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     4320

cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat     4380

aggcgtatca cgaggccctt tcgtc                                           4405




