                         SEQUENCE LISTING

<110>  Lonza Ltd.
 
<120>  HELPER FACTORS FOR EXPRESSING PROTEINS IN YEAST

<130>  LO010P

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly Ile Asp 
1               5                   10                  15      


Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly Arg Val 
            20                  25                  30          


Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser Tyr Val 
        35                  40                  45              


Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn 
    50                  55                  60                  


Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys Arg Leu 
65                  70                  75                  80  


Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile Lys Phe 
                85                  90                  95      


Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile Gln Val 
            100                 105                 110         


Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu Ile Ser 
        115                 120                 125             


Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr Leu Gly 
    130                 135                 140                 


Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe Asn Asp 
145                 150                 155                 160 


Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly Leu Asn 
                165                 170                 175     


Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala Tyr Gly 
            180                 185                 190         


Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp Leu Gly 
        195                 200                 205             


Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly Val Phe 
    210                 215                 220                 


Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe 
225                 230                 235                 240 


Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys Lys Thr 
                245                 250                 255     


Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu Arg Arg 
            260                 265                 270         


Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln Ala Arg 
        275                 280                 285             


Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu Thr Leu 
    290                 295                 300                 


Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg Ser Thr 
305                 310                 315                 320 


Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys Lys Ser 
                325                 330                 335     


Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys 
            340                 345                 350         


Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro Ser Arg 
        355                 360                 365             


Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val Gln Ala 
    370                 375                 380                 


Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu Leu Asp 
385                 390                 395                 400 


Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val Met Thr 
                405                 410                 415     


Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser Gln Ile 
            420                 425                 430         


Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys Val Tyr 
        435                 440                 445             


Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly Thr Phe 
    450                 455                 460                 


Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu 
465                 470                 475                 480 


Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr Ala Glu 
                485                 490                 495     


Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn Asp Gln 
            500                 505                 510         


Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp Ala Glu 
        515                 520                 525             


Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp Thr Arg 
    530                 535                 540                 


Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile Gly Asp 
545                 550                 555                 560 


Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu Thr Met 
                565                 570                 575     


Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His Gln Asp 
            580                 585                 590         


Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu Glu Ile 
        595                 600                 605             


Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro Pro Pro 
    610                 615                 620                 


Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
625                 630                 635     


<210>  2
<211>  1965
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggccgaggag       60

gaggacaaga aggaggacgt gggcacggtg gtcggcatcg acctggggac cacctactcc      120

tgcgtcggcg tgttcaagaa cggccgcgtg gagatcatcg ccaacgatca gggcaaccgc      180

atcacgccgt cctatgtcgc cttcactcct gaaggggaac gtctgattgg cgatgccgcc      240

aagaaccagc tcacctccaa ccccgagaac acggtctttg acgccaagcg gctcatcggc      300

cgcacgtgga atgacccgtc tgtgcagcag gacatcaagt tcttgccgtt caaggtggtt      360

gaaaagaaaa ctaaaccata cattcaagtt gatattggag gtgggcaaac aaagacattt      420

gctcctgaag aaatttctgc catggttctc actaaaatga aagaaaccgc tgaggcttat      480

ttgggaaaga aggttaccca tgcagttgtt actgtaccag cctattttaa tgatgcccaa      540

cgccaagcaa ccaaagacgc tggaactatt gctggcctaa atgttatgag gatcatcaac      600

gagcctacgg cagctgctat tgcttatggc ctggataaga gggaggggga gaagaacatc      660

ctggtgtttg acctgggtgg cggaaccttc gatgtgtctc ttctcaccat tgacaatggt      720

gtcttcgaag ttgtggccac taatggagat actcatctgg gtggagaaga ctttgaccag      780

cgtgtcatgg aacacttcat caaactgtac aaaaagaaga cgggcaaaga tgtcaggaaa      840

gacaatagag ctgtgcagaa actccggcgc gaggtagaaa aggccaaacg ggccctgtct      900

tctcagcatc aagcaagaat tgaaattgag tccttctatg aaggagaaga cttttctgag      960

accctgactc gggccaaatt tgaagagctc aacatggatc tgttccggtc tactatgaag     1020

cccgtccaga aagtgttgga agattctgat ttgaagaagt ctgatattga tgaaattgtt     1080

cttgttggtg gctcgactcg aattccaaag attcagcaac tggttaaaga gttcttcaat     1140

ggcaaggaac catcccgtgg cataaaccca gatgaagctg tagcgtatgg tgctgctgtc     1200

caggctggtg tgctctctgg tgatcaagat acaggtgacc tggtactgct tgatgtatgt     1260

ccccttacac ttggtattga aactgtggga ggtgtcatga ccaaactgat tccaaggaac     1320

acagtggtgc ctaccaagaa gtctcagatc ttttctacag cttctgataa tcaaccaact     1380

gttacaatca aggtctatga aggtgaaaga cccctgacaa aagacaatca tcttctgggt     1440

acatttgatc tgactggaat tcctcctgct cctcgtgggg tcccacagat tgaagtcacc     1500

tttgagatag atgtgaatgg tattcttcga gtgacagctg aagacaaggg tacagggaac     1560

aaaaataaga tcacaatcac caatgaccag aatcgcctga cacctgaaga aatcgaaagg     1620

atggttaatg atgctgagaa gtttgctgag gaagacaaaa agctcaagga gcgcattgat     1680

actagaaatg agttggaaag ctatgcctat tctctaaaga atcagattgg agataaagaa     1740

aagctgggag gtaaactttc ctctgaagat aaggagacca tggaaaaagc tgtagaagaa     1800

aagattgaat ggctggaaag ccaccaagat gctgacattg aagacttcaa agctaagaag     1860

aaggaactgg aagaaattgt tcaaccaatt atcagcaaac tctatggaag tgcaggccct     1920

cccccaactg gtgaagagga tacagcagaa aaagatgagt tgtag                     1965


<210>  3
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Ala Val Met Ser Val Asp Leu Gly Ser Glu Ser Met Lys Val Ala 
1               5                   10                  15      


Ile Val Lys Pro Gly Val Pro Met Glu Ile Val Leu Asn Lys Glu Ser 
            20                  25                  30          


Arg Arg Lys Thr Pro Val Ile Val Thr Leu Lys Glu Asn Glu Arg Phe 
        35                  40                  45              


Phe Gly Asp Ser Ala Ala Ser Met Ala Ile Lys Asn Pro Lys Ala Thr 
    50                  55                  60                  


Leu Arg Tyr Phe Gln His Leu Leu Gly Lys Gln Ala Asp Asn Pro His 
65                  70                  75                  80  


Val Ala Leu Tyr Gln Ala Arg Phe Pro Glu His Glu Leu Thr Phe Asp 
                85                  90                  95      


Pro Gln Arg Gln Thr Val His Phe Gln Ile Ser Ser Gln Leu Gln Phe 
            100                 105                 110         


Ser Pro Glu Glu Val Leu Gly Met Val Leu Asn Tyr Ser Arg Ser Leu 
        115                 120                 125             


Ala Glu Asp Phe Ala Glu Gln Pro Ile Lys Asp Ala Val Ile Thr Val 
    130                 135                 140                 


Pro Val Phe Phe Asn Gln Ala Glu Arg Arg Ala Val Leu Gln Ala Ala 
145                 150                 155                 160 


Arg Met Ala Gly Leu Lys Val Leu Gln Leu Ile Asn Asp Asn Thr Ala 
                165                 170                 175     


Thr Ala Leu Ser Tyr Gly Val Phe Arg Arg Lys Asp Ile Asn Thr Thr 
            180                 185                 190         


Ala Gln Asn Ile Met Phe Tyr Asp Met Gly Ser Gly Ser Thr Val Cys 
        195                 200                 205             


Thr Ile Val Thr Tyr Gln Met Val Lys Thr Lys Glu Ala Gly Met Gln 
    210                 215                 220                 


Pro Gln Leu Gln Ile Arg Gly Val Gly Phe Asp Arg Thr Leu Gly Gly 
225                 230                 235                 240 


Leu Glu Met Glu Leu Arg Leu Arg Glu Arg Leu Ala Gly Leu Phe Asn 
                245                 250                 255     


Glu Gln Arg Lys Gly Gln Arg Ala Lys Asp Val Arg Glu Asn Pro Arg 
            260                 265                 270         


Ala Met Ala Lys Leu Leu Arg Glu Ala Asn Arg Leu Lys Thr Val Leu 
        275                 280                 285             


Ser Ala Asn Ala Asp His Met Ala Gln Ile Glu Gly Leu Met Asp Asp 
    290                 295                 300                 


Val Asp Phe Lys Ala Lys Val Thr Arg Val Glu Phe Glu Glu Leu Cys 
305                 310                 315                 320 


Ala Asp Leu Phe Glu Arg Val Pro Gly Pro Val Gln Gln Ala Leu Gln 
                325                 330                 335     


Ser Ala Glu Met Ser Leu Asp Glu Ile Glu Gln Val Ile Leu Val Gly 
            340                 345                 350         


Gly Ala Thr Arg Val Pro Arg Val Gln Glu Val Leu Leu Lys Ala Val 
        355                 360                 365             


Gly Lys Glu Glu Leu Gly Lys Asn Ile Asn Ala Asp Glu Ala Ala Ala 
    370                 375                 380                 


Met Gly Ala Val Tyr Gln Ala Ala Ala Leu Ser Lys Ala Phe Lys Val 
385                 390                 395                 400 


Lys Pro Phe Val Val Arg Asp Ala Val Val Tyr Pro Ile Leu Val Glu 
                405                 410                 415     


Phe Thr Arg Glu Val Glu Glu Glu Pro Gly Ile His Ser Leu Lys His 
            420                 425                 430         


Asn Lys Arg Val Leu Phe Ser Arg Met Gly Pro Tyr Pro Gln Arg Lys 
        435                 440                 445             


Val Ile Thr Phe Asn Arg Tyr Ser His Asp Phe Asn Phe His Ile Asn 
    450                 455                 460                 


Tyr Gly Asp Leu Gly Phe Leu Gly Pro Glu Asp Leu Arg Val Phe Gly 
465                 470                 475                 480 


Ser Gln Asn Leu Thr Thr Val Lys Leu Lys Gly Val Gly Asp Ser Phe 
                485                 490                 495     


Lys Lys Tyr Pro Asp Tyr Glu Ser Lys Gly Ile Lys Ala His Phe Asn 
            500                 505                 510         


Leu Asp Glu Ser Gly Val Leu Ser Leu Asp Arg Val Glu Ser Val Phe 
        515                 520                 525             


Glu Thr Leu Val Glu Asp Ser Ala Glu Glu Glu Ser Thr Leu Thr Lys 
    530                 535                 540                 


Leu Gly Asn Thr Ile Ser Ser Leu Phe Gly Gly Gly Thr Thr Pro Asp 
545                 550                 555                 560 


Ala Lys Glu Asn Gly Thr Asp Thr Val Gln Glu Glu Glu Glu Ser Pro 
                565                 570                 575     


Ala Glu Gly Ser Lys Asp Glu Pro Gly Glu Gln Val Glu Leu Lys Glu 
            580                 585                 590         


Glu Ala Glu Ala Pro Val Glu Asp Gly Ser Gln Pro Pro Pro Pro Glu 
        595                 600                 605             


Pro Lys Gly Asp Ala Thr Pro Glu Gly Glu Lys Ala Thr Glu Lys Glu 
    610                 615                 620                 


Asn Gly Asp Lys Ser Glu Ala Gln Lys Pro Ser Glu Lys Ala Glu Ala 
625                 630                 635                 640 


Gly Pro Glu Gly Val Ala Pro Ala Pro Glu Gly Glu Lys Lys Gln Lys 
                645                 650                 655     


Pro Ala Arg Lys Arg Arg Met Val Glu Glu Ile Gly Val Glu Leu Val 
            660                 665                 670         


Val Leu Asp Leu Pro Asp Leu Pro Glu Asp Lys Leu Ala Gln Ser Val 
        675                 680                 685             


Gln Lys Leu Gln Asp Leu Thr Leu Arg Asp Leu Glu Lys Gln Glu Arg 
    690                 695                 700                 


Glu Lys Ala Ala Asn Ser Leu Glu Ala Phe Ile Phe Glu Thr Gln Asp 
705                 710                 715                 720 


Lys Leu Tyr Gln Pro Glu Tyr Gln Glu Val Ser Thr Glu Glu Gln Arg 
                725                 730                 735     


Glu Glu Ile Ser Gly Lys Leu Ser Ala Ala Ser Thr Trp Leu Glu Asp 
            740                 745                 750         


Glu Gly Val Gly Ala Thr Thr Val Met Leu Lys Glu Lys Leu Ala Glu 
        755                 760                 765             


Leu Arg Lys Leu Cys Gln Gly Leu Phe Phe Arg Val Glu Glu Arg Lys 
    770                 775                 780                 


Lys Trp Pro Glu Arg Leu Ser Ala Leu Asp Asn Leu Leu Asn His Ser 
785                 790                 795                 800 


Ser Met Phe Leu Lys Gly Ala Arg Leu Ile Pro Glu Met Asp Gln Ile 
                805                 810                 815     


Phe Thr Glu Val Glu Met Thr Thr Leu Glu Lys Val Ile Asn Glu Thr 
            820                 825                 830         


Trp Ala Trp Lys Asn Ala Thr Leu Ala Glu Gln Ala Lys Leu Pro Ala 
        835                 840                 845             


Thr Glu Lys Pro Val Leu Leu Ser Lys Asp Ile Glu Ala Lys Met Met 
    850                 855                 860                 


Ala Leu Asp Arg Glu Val Gln Tyr Leu Leu Asn Lys Ala Lys Phe Thr 
865                 870                 875                 880 


Lys Pro Arg Pro Arg Pro Lys Asp Lys Asn Gly Thr Arg Ala Glu Pro 
                885                 890                 895     


Pro Leu Asn Ala Ser Ala Ser Asp Gln Gly Glu Lys Val Ile Pro Pro 
            900                 905                 910         


Ala Gly Gln Thr Glu Asp Ala Glu Pro Ile Ser Glu Pro Glu Lys Val 
        915                 920                 925             


Glu Thr Gly Ser Glu Pro Gly Asp Thr Glu Pro Leu Glu Leu Gly Gly 
    930                 935                 940                 


Pro Gly Ala Glu Pro Glu Gln Lys Glu Gln Ser Thr Gly Gln Lys Arg 
945                 950                 955                 960 


Pro Leu Lys Asn Asp Glu Leu 
                965         


<210>  4
<211>  3000
<212>  DNA
<213>  Homo sapiens

<400>  4
atggcagaca aagttaggag gcagaggccg aggaggcgag tctgttgggc cttggtggct       60

gtgctcttgg cagacctgtt ggcactgagt gatacactgg cagtgatgtc tgtggacctg      120

ggcagtgagt ccatgaaggt ggccattgtc aaacctggag tgcccatgga aattgtcttg      180

aataaggaat ctcggaggaa aacaccggtg atcgtgaccc tgaaagaaaa tgaaagattc      240

tttggagaca gtgcagcaag catggcgatt aagaatccaa aggctacgct acgttacttc      300

cagcacctcc tggggaagca ggcagataac ccccatgtag ctctttacca ggcccgcttc      360

ccggagcacg agctgacttt cgacccacag aggcagactg tgcactttca gatcagctcg      420

cagctgcagt tctcacctga ggaagtgttg ggcatggttc tcaattattc tcgttctcta      480

gctgaagatt ttgcagagca gcccatcaag gatgcagtga tcaccgtgcc agtcttcttc      540

aaccaggccg agcgccgagc tgtgctgcag gctgctcgta tggctggcct caaagtgctg      600

cagctcatca atgacaacac cgccactgcc ctcagctatg gtgtcttccg ccggaaagat      660

attaacacca ctgcccagaa tatcatgttc tatgacatgg gctcaggcag caccgtatgc      720

accattgtga cctaccagat ggtgaagact aaggaagctg ggatgcagcc acagctgcag      780

atccggggag taggatttga ccgtaccctg gggggcctgg agatggagct ccggcttcga      840

gaacgcctgg ctgggctttt caatgagcag cgcaagggtc agagagcaaa ggatgtgcgg      900

gagaacccgc gtgccatggc caagctgctg cgtgaggcta atcggctcaa aaccgtcctc      960

agtgccaacg ctgaccacat ggcacagatt gaaggcctga tggatgatgt ggacttcaag     1020

gcaaaagtga ctcgtgtgga atttgaggag ttgtgtgcag acttgtttga gcgggtgcct     1080

gggcctgtac agcaggccct ccagagtgcc gaaatgagtc tggatgagat tgagcaggtg     1140

atcctggtgg gtggggccac tcgggtcccc agagttcagg aggtgctgct gaaggccgtg     1200

ggcaaggagg agctggggaa gaacatcaat gcagatgaag cagccgccat gggggcagtg     1260

taccaggcag ctgcgctcag caaagccttt aaagtgaagc catttgtcgt ccgagatgca     1320

gtggtctacc ccatcctggt ggagttcacg agggaggtgg aggaggagcc tgggattcac     1380

agcctgaagc acaataaacg ggtactcttc tctcggatgg ggccctaccc tcaacgcaaa     1440

gtcatcacct ttaaccgcta cagccatgat ttcaacttcc acatcaacta cggcgacctg     1500

ggcttcctgg ggcctgaaga tcttcgggta tttggctccc agaatctgac cacagtgaag     1560

ctaaaagggg tgggtgacag cttcaagaag tatcctgact acgagtccaa gggcatcaag     1620

gctcacttca acctggatga gagtggcgtg ctcagtctag acagggtgga gtctgtattt     1680

gagacactgg tagaggacag cgcagaagag gaatctactc tcaccaaact tggcaacacc     1740

atttccagcc tgtttggagg cggtaccaca ccagatgcca aggagaatgg tactgatact     1800

gtccaggagg aagaggagag ccctgcagag gggagcaagg acgagcctgg ggagcaggtg     1860

gagctcaagg aggaagctga ggccccagtg gaggatggct ctcagccccc accccctgaa     1920

cctaagggag atgcaacccc tgagggagaa aaggccacag aaaaagaaaa tggggacaag     1980

tctgaggccc agaaaccaag tgagaaggca gaggcagggc ctgagggcgt cgctccagcc     2040

ccagagggag agaagaagca gaagcccgcc aggaagcggc gaatggtaga ggagatcggg     2100

gtggagctgg ttgttctgga cctgcctgac ttgccagagg ataagctggc tcagtcggtg     2160

cagaaacttc aggacttgac actccgagac ctggagaagc aggaacggga aaaagctgcc     2220

aacagcttgg aagcattcat atttgagacc caggacaagc tgtaccagcc cgagtaccag     2280

gaagtgtcca cagaggagca gcgtgaggag atctctggga agctcagcgc cgcatccacc     2340

tggctggagg atgagggtgt tggagccacc acagtgatgt tgaaggagaa gctggctgag     2400

ctgaggaagc tgtgccaagg gctgtttttt cgggtagagg agcgcaagaa gtggcccgaa     2460

cggctgtctg ccctcgataa tctcctcaac cattccagca tgttcctcaa gggggcccgg     2520

ctcatcccag agatggacca gatcttcact gaggtggaga tgacaacgtt agagaaagtc     2580

atcaatgaga cctgggcctg gaagaatgca actctggccg agcaggctaa gctgcccgcc     2640

acagagaagc ctgtgttgct ctcaaaagac attgaagcta agatgatggc cctggaccga     2700

gaggtgcagt atctgctcaa taaggccaag tttaccaagc cccggccccg gcctaaggac     2760

aagaatggga cccgggcaga gccacccctc aatgccagtg ccagtgacca gggggagaag     2820

gtcatccctc cagcaggcca gactgaagat gcagagccca tttcagaacc tgagaaagta     2880

gagactggat ccgagccagg agacactgag cctttggagt taggaggtcc tggagcagaa     2940

cctgaacaga aagaacaatc gacaggacag aagcggcctt tgaagaacga cgaactataa     3000


<210>  5
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Arg Asp Phe Tyr Lys Ile Leu Gly Val Pro Arg Ser Ala Ser Ile 
1               5                   10                  15      


Lys Asp Ile Lys Lys Ala Tyr Arg Lys Leu Ala Leu Gln Leu His Pro 
            20                  25                  30          


Asp Arg Asn Pro Asp Asp Pro Gln Ala Gln Glu Lys Phe Gln Asp Leu 
        35                  40                  45              


Gly Ala Ala Tyr Glu Val Leu Ser Asp Ser Glu Lys Arg Lys Gln Tyr 
    50                  55                  60                  


Asp Thr Tyr Gly Glu Glu Gly Leu Lys Asp Gly His Gln Ser Ser His 
65                  70                  75                  80  


Gly Asp Ile Phe Ser His Phe Phe Gly Asp Phe Gly Phe Met Phe Gly 
                85                  90                  95      


Gly Thr Pro Arg Gln Gln Asp Arg Asn Ile Pro Arg Gly Ser Asp Ile 
            100                 105                 110         


Ile Val Asp Leu Glu Val Thr Leu Glu Glu Val Tyr Ala Gly Asn Phe 
        115                 120                 125             


Val Glu Val Val Arg Asn Lys Pro Val Ala Arg Gln Ala Pro Gly Lys 
    130                 135                 140                 


Arg Lys Cys Asn Cys Arg Gln Glu Met Arg Thr Thr Gln Leu Gly Pro 
145                 150                 155                 160 


Gly Arg Phe Gln Met Thr Gln Glu Val Val Cys Asp Glu Cys Pro Asn 
                165                 170                 175     


Val Lys Leu Val Asn Glu Glu Arg Thr Leu Glu Val Glu Ile Glu Pro 
            180                 185                 190         


Gly Val Arg Asp Gly Met Glu Tyr Pro Phe Ile Gly Glu Gly Glu Pro 
        195                 200                 205             


His Val Asp Gly Glu Pro Gly Asp Leu Arg Phe Arg Ile Lys Val Val 
    210                 215                 220                 


Lys His Pro Ile Phe Glu Arg Arg Gly Asp Asp Leu Tyr Thr Asn Val 
225                 230                 235                 240 


Thr Ile Ser Leu Val Glu Ser Leu Val Gly Phe Glu Met Asp Ile Thr 
                245                 250                 255     


His Leu Asp Gly His Lys Val His Ile Ser Arg Asp Lys Ile Thr Arg 
            260                 265                 270         


Pro Gly Ala Lys Leu Trp Lys Lys Gly Glu Gly Leu Pro Asn Phe Asp 
        275                 280                 285             


Asn Asn Asn Ile Lys Gly Ser Leu Ile Ile Thr Phe Asp Val Asp Phe 
    290                 295                 300                 


Pro Lys Glu Gln Leu Thr Glu Glu Ala Arg Glu Gly Ile Lys Gln Leu 
305                 310                 315                 320 


Leu Lys Gln Gly Ser Val Gln Lys Val Tyr Asn Gly Leu Gln Gly Tyr 
                325                 330                 335     


<210>  6
<211>  1077
<212>  DNA
<213>  Homo sapiens

<400>  6
atggctccgc agaacctgag caccttttgc ctgttgctgc tatacctcat cggggcggtg       60

attgccggac gagatttcta taagatcttg ggggtgcctc gaagtgcctc tataaaggat      120

attaaaaagg cctataggaa actagccctg cagcttcatc ccgaccggaa ccctgatgat      180

ccacaagccc aggagaaatt ccaggatctg ggtgctgctt atgaggttct gtcagatagt      240

gagaaacgga aacagtacga tacttatggt gaagaaggat taaaagatgg tcatcagagc      300

tcccatggag acattttttc acacttcttt ggggattttg gtttcatgtt tggaggaacc      360

cctcgtcagc aagacagaaa tattccaaga ggaagtgata ttattgtaga tctagaagtc      420

actttggaag aagtatatgc aggaaatttt gtggaagtag ttagaaacaa acctgtggca      480

aggcaggctc ctggcaaacg gaagtgcaat tgtcggcaag agatgcggac cacccagctg      540

ggccctgggc gcttccaaat gacccaggag gtggtctgcg acgaatgccc taatgtcaaa      600

ctagtgaatg aagaacgaac gctggaagta gaaatagagc ctggggtgag agacggcatg      660

gagtacccct ttattggaga aggtgagcct cacgtggatg gggagcctgg agatttacgg      720

ttccgaatca aagttgtcaa gcacccaata tttgaaagga gaggagatga tttgtacaca      780

aatgtgacaa tctcattagt tgagtcactg gttggctttg agatggatat tactcacttg      840

gatggtcaca aggtacatat ttcccgggat aagatcacca ggccaggagc gaagctatgg      900

aagaaagggg aagggctccc caactttgac aacaacaata tcaagggctc tttgataatc      960

acttttgatg tggattttcc aaaagaacag ttaacagagg aagcgagaga aggtatcaaa     1020

cagctactga aacaagggtc agtgcagaag gtatacaatg gactgcaagg atattga        1077


<210>  7
<211>  1968
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized nucleotide sequence

<400>  7
atgaagttgt ccttggtcgc tgctatgctg ttgttgttgt ctgctgctag agctgaggaa       60

gaggacaaga aagaggacgt tggtactgtt gttggtatcg acttgggtac tacctactcc      120

tgtgtcggtg ttttcaagaa cggtagagtc gagattatcg ctaacgacca aggtaacaga      180

atcaccccat cctacgttgc tttcactcca gagggtgaga gattgattgg tgacgctgct      240

aagaaccaat tgacctccaa cccagagaac accgttttcg acgctaagag attgatcggt      300

agaacctgga acgacccatc cgttcaacaa gacatcaagt tcttgccatt caaggtcgtc      360

gagaagaaga ccaagcctta catccaagtt gacatcggtg gtggtcaaac taagaccttc      420

gctcctgaag agatctccgc tatggttttg accaagatga aagaaaccgc tgaggcttac      480

ttgggtaaga aggttactca cgctgttgtt accgtcccag cttacttcaa cgacgctcaa      540

agacaagcta ctaaggacgc tggtactatc gctggtttga acgtcatgag aatcatcaac      600

gagccaaccg ctgctgctat tgcttacggt ttggacaaaa gagaaggaga gaagaacatc      660

ttggttttcg acttgggtgg tggtactttc gacgtttcct tgttgactat cgacaacggt      720

gttttcgagg tcgttgctac caacggtgat actcacttgg gtggtgagga cttcgaccaa      780

agagttatgg aacacttcat caagttgtac aagaagaaga ctggtaagga cgtcagaaag      840

gacaacagag ctgtccaaaa gttgagaaga gaggtcgaga aggctaagag agctttgtcc      900

tctcaacacc aagctagaat cgagatcgag tccttctacg agggtgagga tttctctgag      960

actttgacca gagctaagtt cgaggaattg aacatggact tgttcagatc caccatgaag     1020

ccagtccaaa aggttttgga ggactccgac ttgaagaagt ctgacatcga cgagatcgtt     1080

ttggttggtg gttctaccag aatcccaaag atccaacaat tggtcaaaga attcttcaac     1140

ggtaaagaac catccagagg tatcaaccca gacgaggctg ttgcttacgg tgctgctgtt     1200

caagctggtg ttttgtctgg tgaccaagac actggtgact tggttttgtt ggacgtctgt     1260

ccattgacct tgggtatcga gactgttggt ggtgtcatga ccaagttgat cccaagaaac     1320

accgtcgtcc caactaagaa gtcccaaatc ttctctaccg cttccgacaa ccaacctacc     1380

gttaccatta aggtttacga gggtgaaaga ccattgacta aggacaacca cttgttgggt     1440

actttcgatt tgactggtat cccaccagct ccaagaggtg ttccacaaat cgaggttact     1500

ttcgagatcg acgtcaacgg tatcttgaga gttactgctg aggacaaggg tactggtaac     1560

aagaacaaga tcaccatcac caacgaccaa aacagattga cccctgaaga gattgagaga     1620

atggtcaacg acgctgagaa gttcgctgag gaagataaga agttgaaaga aagaatcgac     1680

accagaaacg agttggagtc ctacgcttac tccttgaaga accaaatcgg tgacaaagaa     1740

aagttgggag gtaagttgtc ctccgaggat aaagaaacca tggaaaaggc tgtcgaagag     1800

aagatcgagt ggttggagtc tcaccaagac gctgacattg aggacttcaa ggctaagaag     1860

aaagaattgg aggaaatcgt ccaacctatc atctccaagt tgtacggttc tgctggtcca     1920

ccaccaactg gtgaagaaga tactgctgag aaggacgagt tgtaatag                  1968


<210>  8
<211>  2907
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized nucleotide sequence

<400>  8
ttggctgtca tgtctgttga cttgggttcc gagtctatga aggtcgctat cgttaagcca       60

ggtgtcccaa tggaaatcgt cttgaacaag gaatccagaa gaaagacccc agtcatcgtc      120

accttgaagg aaaacgagag attcttcggt gactccgctg cttctatggc tatcaagaac      180

ccaaaggcta ccttgagata cttccaacac ttgttgggta agcaagctga caacccacac      240

gtcgccttgt accaagctag attcccagag cacgagttga ctttcgaccc acaaagacaa      300

accgtccact tccaaatctc ttcccaattg caattctccc cagaggaagt cttgggtatg      360

gtcttgaact actccagatc tttggctgag gacttcgctg agcaacctat taaggacgct      420

gttatcaccg tcccagtttt cttcaaccag gctgagagaa gagctgtctt gcaagctgct      480

agaatggctg gtttgaaggt cttgcaattg atcaacgaca acaccgctac cgctttgtcc      540

tacggtgttt tcagaagaaa ggacatcaac accaccgctc aaaacatcat gttctacgac      600

atgggttctg gttccaccgt ctgtactatc gtcacctacc aaatggtcaa gaccaaggaa      660

gctggtatgc aaccacaatt gcaaatcaga ggtgtcggtt tcgacagaac cttgggtggt      720

ttggagatgg aattgagatt gagagagaga ttggctggtt tgttcaacga gcaaagaaag      780

ggtcaaagag ctaaggacgt cagagaaaac ccaagagcta tggctaagtt gttgagagag      840

gctaacagat tgaagaccgt cttgtctgct aacgctgacc acatggctca aatcgagggt      900

ttgatggacg acgttgactt caaggctaag gttaccagag tcgagttcga ggaattgtgt      960

gctgacttgt tcgagagagt tccaggtcca gttcaacaag ccttgcaatc tgctgagatg     1020

tccttggacg agatcgagca agttatcttg gttggtggtg ctaccagagt cccaagagtt     1080

caagaggttt tgttgaaggc tgtcggtaag gaagagttgg gtaagaacat taacgctgac     1140

gaggctgctg ctatgggtgc tgtttaccaa gctgctgctt tgtccaaggc tttcaaggtt     1200

aagccattcg tcgtcagaga tgctgtcgtc tacccaatct tggttgagtt caccagagag     1260

gtcgaggaag aaccaggtat ccactctttg aagcacaaca agagagtctt gttctccaga     1320

atgggtccat acccacaaag aaaggtcatc accttcaaca gatactccca cgacttcaac     1380

ttccacatca actacggtga cttgggtttc ttgggtccag aggacttgag agttttcggt     1440

tcccaaaact tgaccaccgt caagttgaag ggtgttggtg actccttcaa gaagtaccca     1500

gactacgagt ccaagggtat caaggctcac ttcaacttgg acgagtctgg tgttttgtcc     1560

ttggacagag ttgagtccgt tttcgagact ttggttgagg actctgctga agaggaatcc     1620

accttgacta agttgggtaa caccatctct tccttgttcg gtggtggtac tactccagac     1680

gctaaggaaa acggtactga caccgttcaa gaggaagagg aatctccagc tgagggttct     1740

aaggacgaac caggtgagca agttgagttg aaggaagagg ctgaagctcc agttgaggac     1800

ggttctcaac caccaccacc agaacctaag ggtgatgcta ctccagaagg tgagaaggct     1860

actgagaagg aaaacggtga caagtccgag gctcaaaagc catctgaaaa ggctgaagct     1920

ggtccagaag gtgttgctcc agctcctgaa ggtgaaaaga agcaaaagcc agctagaaag     1980

agaagaatgg tcgaagagat cggtgtcgag ttggtcgttt tggacttgcc agatttgcca     2040

gaggacaagt tggctcaatc cgtccaaaag ttgcaagact tgaccttgag agacttggag     2100

aagcaagaga gagagaaggc tgctaactct ttggaggctt tcatcttcga gactcaagac     2160

aagttgtacc aacctgagta ccaagaggtt tccaccgagg aacaaagaga ggaaatctcc     2220

ggtaagttgt ctgctgcttc tacttggttg gaggacgaag gtgttggtgc tactaccgtt     2280

atgttgaagg aaaagttggc tgagttgaga aagttgtgtc aaggtttgtt cttcagagtc     2340

gaagaaagaa agaagtggcc agagagattg tccgctttgg acaacttgtt gaaccactct     2400

tccatgttct tgaagggtgc tagattgatc ccagagatgg accaaatctt caccgaggtt     2460

gagatgacca ccttggagaa ggttatcaac gagacttggg cttggaagaa cgctactttg     2520

gctgagcaag ctaagttgcc agctaccgag aagccagttt tgttgtctaa ggacatcgag     2580

gctaagatga tggctttgga cagagaggtc caatacttgt tgaacaaggc taagttcacc     2640

aagccaagac caagacctaa ggacaagaac ggtactagag ctgagcctcc tttgaacgct     2700

tctgcttctg accaaggtga aaaggttatt ccaccagctg gtcaaactga ggacgctgag     2760

ccaatttctg agccagagaa ggttgagact ggttctgaac caggtgacac tgagccattg     2820

gaattgggtg gtccaggtgc tgaaccagag caaaaggaac aatccactgg tcaaaagaga     2880

ccattgaaga acgacgagtt gtaatag                                         2907


<210>  9
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized nucleotide sequence

<400>  9
atggctccac aaaacttgtc cactttctgt ttgttgttgt tgtacttgat cggtgctgtt       60

atcgctggta gagacttcta caagatcttg ggtgttccaa gatccgcttc catcaaggac      120

atcaagaagg cttacagaaa gttggctttg caattgcacc cagacagaaa cccagacgac      180

ccacaagctc aagagaagtt ccaagatttg ggtgctgctt acgaggtttt gtctgactcc      240

gagaagagaa agcaatacga cacctacggt gaggaaggtt tgaaggacgg tcaccaatct      300

tctcacggtg atatcttctc ccacttcttc ggtgacttcg gtttcatgtt cggtggtact      360

ccaagacaac aagacagaaa catcccaaga ggttccgaca tcatcgttga cttggaggtt      420

accttggagg aagtctacgc tggtaacttc gttgaggtcg tcagaaacaa gccagtcgct      480

agacaagctc caggtaagag aaagtgtaac tgtagacaag agatgagaac cactcaattg      540

ggtccaggta gattccaaat gacccaagag gttgtctgtg acgagtgtcc aaacgtcaag      600

ttggtcaacg aggaaagaac cttggaggtt gagattgagc caggtgtcag agatggtatg      660

gaatacccat tcattggtga gggtgagcca cacgttgatg gtgaaccagg tgacttgaga      720

ttcagaatca aggtcgtcaa gcacccaatc ttcgagagaa gaggtgacga cttgtacacc      780

aacgtcacca tttctttggt cgagtccttg gtcggtttcg agatggacat tactcacttg      840

gacggtcaca aggtccacat ctctagagac aagattacca gaccaggtgc taagttgtgg      900

aagaagggtg agggtttgcc aaacttcgat aacaacaaca tcaagggttc cttgatcatc      960

accttcgacg tcgacttccc aaaggaacaa ttgaccgagg aagctagaga gggtatcaag     1020

caattgttga agcaaggttc cgtccaaaag gtctacaacg gtttgcaagg ttactaatag     1080


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X at position 3 is either F or L

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X at position 16 is either A or T

<400>  10

Met Lys Xaa Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Xaa 
1               5                   10                  15      


Val Val Ser Ala 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  11

Met Lys Phe Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Ala 
1               5                   10                  15      


Val Val Ser Ala 
            20  


<210>  12
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  12
atgaagttct ccaccaattt gattctagct attgcagcag cttccgccgt tgtctcagct       60


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X at position 3 is either F or L

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X at position 16 is either A or T

<400>  13

Met Lys Xaa Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Xaa 
1               5                   10                  15      


Val Val Ser Ala Ala Pro Val Ala Pro Ala Glu Glu Ala Ala Asn His 
            20                  25                  30          


Leu His Lys Arg 
        35      


<210>  14
<211>  85
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  15
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala 
        


<210>  16
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Asp Lys Val Arg Arg Gln Arg Pro Arg Arg Arg Val Cys Trp 
1               5                   10                  15      


Ala Leu Val Ala Val Leu Leu Ala Asp Leu Leu Ala Leu Ser Asp Thr 
            20                  25                  30          


<210>  17
<211>  45
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Phe Phe Asn Arg Leu Ser Ala Gly Lys Leu Leu Val Pro Leu Ser 
1               5                   10                  15      


Val Val Leu Tyr Ala Leu Phe Val Val Ile Leu Pro Leu Gln Asn Ser 
            20                  25                  30          


Phe His Ser Ser Asn Val Leu Val Arg Gly Ala Asp Asp 
        35                  40                  45  


<210>  18
<211>  135
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  18
atgtttttca acagactaag cgctggcaag ctgctggtac cactctccgt ggtcctgtac       60

gcccttttcg tggtaatatt acctttacag aattctttcc actcctccaa tgttttagtt      120

agaggtgccg atgat                                                       135


<210>  19
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Pro Gln Asn Leu Ser Thr Phe Cys Leu Leu Leu Leu Tyr Leu 
1               5                   10                  15      


Ile Gly Ala Val Ile Ala 
            20          


<210>  20
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Asp Glu Leu 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  21

Asn Asp Glu Leu 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Asp Glu Leu 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Asp Glu Leu 
1               


<210>  24
<211>  491
<212>  DNA
<213>  Pichia pastoris

<400>  24
cttttttgta gaaatgtctt ggtgtcctcg tccaatcagg tagccatctc tgaaatatct       60

ggctccgttg caactccgaa cgacctgctg gcaacgtaaa attctccggg gtaaaactta      120

aatgtggagt aatggaacca gaaacgtctc ttcccttctc tctccttcca ccgcccgtta      180

ccgtccctag gaaattttac tctgctggag agcttcttct acggccccct tgcagcaatg      240

ctcttcccag cattacgttg cgggtaaaac ggaggtcgtg tacccgacct agcagcccag      300

ggatggaaaa gtcccggccg tcgctggcaa taatagcggg cggacgcatg tcatgagatt      360

attggaaacc accagaatcg aatataaaag gcgaacacct ttcccaattt tggtttctcc      420

tgacccaaag actttaaatt taatttattt gtccctattt caatcaattg aacaactatc      480

acctgcaggc c                                                           491


<210>  25
<211>  488
<212>  DNA
<213>  Pichia pastoris

<400>  25
cttttttgta gaaatgtctt ggtgtcctcg tccaatcagg tagccatctc tgaaatatct       60

ggctccgttg caactccgaa cgacctgctg gcaacgtaaa attctccggg gtaaaactta      120

aatgtggagt aatggaacca gaaacgtctc ttcccttctc tctccttcca ccgcccgtta      180

ccgtccctag gaaattttac tctgctggag agcttcttct acggccccct tgcagcaatg      240

ctcttcccag cattacgttg cgggtaaaac ggaggtcgtg tacccgacct agcagcccag      300

ggatggaaaa gtcccggccg tcgctggcaa taatagcggg cggacgcatg tcatgagatt      360

attggaaacc accagaatcg aatataaaag gcgaacacct ttcccaattt tggtttctcc      420

tgacccaaag actttaaatt taatttattt gtccctattt caatcaattg aacaactatc      480

aaaacaca                                                               488


<210>  26
<211>  985
<212>  DNA
<213>  Pichia pastoris

<400>  26
agggcatcat tgaggtttcc acaaaaggaa gaaacatgga tccagagaca tcaacagaga       60

ggaaagcggg tagtgaagcc gaagccacaa cacagcccga tttggaaggg agttcacaat      120

caaggtgagt ccagccattt tttttctttt tttttttttt attcaggtga acccacctaa      180

ctatttttaa ctgggatcca gtgagctcgc tgggtgaaag ccaaccatct tttgtttcgg      240

ggaaccgtgc tcgccccgta aagttaattt ttttttcccg cgcagcttta atctttcggc      300

agagaaggcg ttttcatcgt agcgtgggaa cagaataatc agttcatgtg ctatacaggc      360

acatggcagc agtcactatt ttgcttttta accttaaagt cgttcatcaa tcattaactg      420

accaatcaga ttttttgcat ttgccactta tctaaaaata cttttgtatc tcgcagatac      480

gttcagtggt ttccaggaca acacccaaaa aaaggtatca atgccactag gcagtcggtt      540

ttatttttgg tcacccacgc aaagaagcac ccacctcttt taggttttaa gttgtgggaa      600

cagtaacacc gcctagagct tcaggaaaaa ccagtacctg tgaccgcaat tcaccatgat      660

gcagaatgtt aatttaaacg agtgccaaat caagatttca acagacaaat caatcgatcc      720

atagttaccc attccagcct tttcgtcgtc gagcctgctt cattcctgcc tcaggtgcat      780

aactttgcat gaaaagtcca gattagggca gattttgagt ttaaaatagg aaatataaac      840

aaatataccg cgaaaaaggt ttgtttatag cttttcgcct ggtgccgtac ggtataaata      900

catactctcc tcccccccct ggttctcttt ttcttttgtt acttacattt taccgttccg      960

tcactcgctt cactcaacaa caaaa                                            985


<210>  27
<211>  1001
<212>  DNA
<213>  Pichia pastoris

<400>  27
catgttggta ttgtgaaata gacgcagatc gggaacactg aaaaataaca gttattattc       60

gagatctaac atccaaagac gaaaggttga atgaaacctt tttgccatcc gacatccaca      120

ggtccattct cacacataag tgccaaacgc aacaggaggg gatacactag cagcagaccg      180

ttgcaaacgc aggacctcca ctcctcttct cctcaacacc cacttttgcc atcgaaaaac      240

cagcccagtt attgggcttg attggagctc gctcattcca attccttcta ttaggctact      300

aacaccatga ctttattagc ctgtctatcc tggcccccct ggcgaggttc atgtttgttt      360

atttccgaat gcaacaagct ccgcattaca cccgaacatc actccagatg agggctttct      420

gagtgtgggg tcaaatagtt tcatgttccc caaatggccc aaaactgaca gtttaaacgc      480

tgtcttggaa cctaatatga caaaagcgtg atctcatcca agatgaacta agtttggttc      540

gttgaaatgc taacggccag ttggtcaaaa agaaacttcc aaaagtcggc ataccgtttg      600

tcttgtttgg tattgattga cgaatgctca aaaataatct cattaatgct tagcgcagtc      660

tctctatcgc ttctgaaccc cggtgcacct gtgccgaaac gcaaatgggg aaacacccgc      720

tttttggatg attatgcatt gtctccacat tgtatgcttc caagattctg gtgggaatac      780

tgctgatagc ctaacgttca tgatcaaaat ttaactgttc taacccctac ttgacagcaa      840

tatataaaca gaaggaagct gccctgtctt aaaccttttt ttttatcatc attattagct      900

tactttcata attgcgactg gttccaattg acaagctttt gattttaacg acttttaacg      960

acaacttgag aagatcaaaa aacaactaat tattcgaaac g                         1001


<210>  28
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  28
gcttaaagga ctccatttcc taaaatttca agcagtcctc tcaactaaat ttttttccat       60

tcctctgcac ccagccctct tcatcaaccg tccagccttc tcaaaagtcc aatgtaagta      120

gcctgcaaat tcaggttaca acccctcaat tttccatcca agggcgatcc ttacaaagtt      180

aatatcgaac agcagagact aagcgagtca tcatcaccac ccaacgatgg tgaaaaactt      240

taagcataga ttgatggagg gtgtatggca cttggcggct gcattagagt ttgaaactat      300

ggggtaatac atcacatccg gaactgatcc gactccgaga tcatatgcaa agcacgtgat      360

gtaccccgta aactgctcgg attatcgttg caattcatcg tcttaaacag tacaagaaac      420

tttattcatg ggtcattgga ctctgatgag gggcacattt ccccaatgat tttttgggaa      480

agaaagccgt aagaggacag ttaagcgaaa gagacaagac aacgaacagc aaaagtgaca      540

gctgtcagct acctagtgga cagttgggag tttccaattg gttggttttg aatttttacc      600

catgttgagt tgtccttgct tctccttgca aacaatgcaa gttgataaga catcaccttc      660

caagataggc tatttttgtc gcataaattt ttgtctcgga gtgaaaaccc cttttatgtg      720

aacagattac agaagcgtcc tacccttcac cggttgagat ggggagaaaa ttaagcgatg      780

aggagacgat tattggtata aaagaagcaa ccaaaatccc ttattgtcct tttctgatca      840

gcatcaaaga atattgtctt aaaacgggct tttaactaca ttgttcttac acattgcaaa      900

cctcttcctt ctatttcgga tcaactgtat tgactacatt gatctttttt aacgaagttt      960

acgacttact aaatccccac aaacaaatca actgagaaaa                           1000


<210>  29
<211>  975
<212>  DNA
<213>  Pichia pastoris

<400>  29
gtagcttggg taggacttga caagtacggc ttccgtggtc ataccaaacg cctttgttac       60

cgttggctat acctaatgac caaggcattt gtggattata acggtatcgt agttgaaaaa      120

tatgacgtaa ccactggtac tagcccccac aaggttgatg ctgaatacgg gaatcaaggt      180

gccgatttta aaggagtagc cactgaaggg tttggctggg tcaatgcctc ttttattttg      240

ggattaacct acttagatgt ccaaggcatc cgtgcgatag gcgccgttac gtcccctgat      300

gtatttttca ggaagctcaa accttgggaa cgcgcaagtt atggcctaag gccatgtaac      360

gagatagtca agtcaaacta gaagtatacg gtttccccgc agaaatagca gaaataggcg      420

acaaatacat acaacatttt cattgtgata gggggcggcg gttcctagga gggacaaccc      480

ccagaaacct tgtagactac gttttcacga cgatgggtta ttactgtaaa ggaagaatat      540

actacccacc agttgaatgt ttgaacggat caaaggtcga agggagtaca cggcccaacc      600

aacgtagcta ccggagaaag caagactttc ccaaaccaaa tagctccggg tttcttctcc      660

ggcaacccgt cagtttttgt gtggccggac aaaaattcgc accctcagtc taattgaaag      720

gtcgggctcc gagctctagg cgtttgcgca tgtaatattg catcccctcc catagataat      780

actgcgcgaa cacagggtgc aaattatgat gaccacacat gccagtgacc aaaacagttt      840

tttagtcttt aaaaaccctc ggaacttctg agtatataaa ggcttctcat ttcctacaag      900

caaacaaaga agaaacttcc actttctaac tttttatcta tagactttag agttacaacc      960

aacgaacaat aacaa                                                       975


<210>  30
<211>  699
<212>  DNA
<213>  Pichia pastoris

<400>  30
cgcattattt gggtcggcta ctgtcattgg ttatgatggc cttaccgagc acgaaggtgg       60

ttggatagac cacaactgga aacagttgta caaacagatt gcattcattt ttgcttgtat      120

tggatactcg atggccatca ccgctcttat ctgtttcatc ctcaaccgta ttccattttt      180

gcaactgcga gcttcagaag aggctgagga gaaaggtatg gatgaggatc agattggaga      240

gttcgcttat gactacgtgg aagtacgtcg tgattttttg gcttggggat caggcccaaa      300

caatggcttc aaggagccgg aagttctgga tcaggtagtt ccggttaatg atttcagcag      360

tgaccagaat gtgactaatc agaccaacga atctgagaag cagtagagta aatatagaga      420

tgatatttag tgtattctaa tgcttatgta atgtattaag caaaaagttg tgtttatgag      480

ttagcatttg tcttagcaaa cataaaatta tgtcgacatt tgcaacccgc atgtctagtg      540

tttttagatc gatcttcgat gtgtagaata atgcctccac gtgatgcccc gcgattttgt      600

tgggtcgcaa tgcctccaac ataaacccat cacgtataaa aagccctctt aaccctcccc      660

cctgtttcgt ttgcttcatc acttaacctg aactatcaa                             699


<210>  31
<211>  991
<212>  DNA
<213>  Pichia pastoris

<400>  31
gcaaggcaac tgagaaattg aatagtggtt tcaagcccgc tgactttttg tattatctca       60

atgtcggtgt ttcacagtcc ccagaagggg gctttgcctt caagggagac ggaagagaca      120

tcgtcaaccc tggggagaag tatttcaaat ggcgcaagtt cgctaatttt tacgattaag      180

cagtgctgta tggggtagtt aataaatcgg gaatatcctt ctgacgtgac tgtaacaaat      240

ctctttttac gtggtgcgca tactggacag aggcagagtc tcaatttctt cttttgagac      300

aggctactac agcctgtgat tcctcttggt acttggattt gcttttatct ggctccgttg      360

ggaactgtgc ctgggttttg aagtatcttg tggatgtgtt tctaacactt tttcaatctt      420

cttggagtga gaatgcagga ctttgaacat cgtctagctc gttggtaggt gaaccgtttt      480

accttgcatg tggttaggag ttttctggag taaccaagac cgtcttatca tcgccgtaaa      540

atcgctctta ctgtcgctaa taatcccgct ggaagagaag ttcgaacaga agtagcacgc      600

aaagctcttg tcaaatgaga attgttaatc gtttgacagg tcacactcgt gggctatgta      660

cgatcaactt gccggctgtt gctggagaga tgacaccagt tgtggcatgg ccaattggta      720

ttcagccgta ccactgtatg gaaaatgaga ttatcttgtt cttgatctag tttcttgcca      780

ttttagagtt gccacattcg taggtttcag taccaataat ggtaacttcc aaacttccaa      840

cgcagatacc agagatctgc cgatccttcc ccaacaatag gagcttacta cgccatacat      900

atagcctatc tattttcact ttcgcgtggg tgcttctata taaacggttc cccatcttcc      960

gtttcatact acttgaattt taagcactaa a                                     991


<210>  32
<211>  864
<212>  DNA
<213>  Pichia pastoris

<400>  32
cttttctttg ggcaaggaaa aatcaagaaa aagcagaggt taaagttttc aggggaatgg       60

caattgcttt atatatggga gaaagttaac tacgtcggtg ctgtaggcgt agagagcgac      120

tggagaatgc gtgatgaggt cgtctctttt cgccccccct tggcggggta aaaattgcac      180

tactgcagaa ttactacacc cctattccga ggagacggag tgcgacaaaa atggtaaagt      240

tcaccctagt ctgcgacttt taattgacgg acaccggcgt ttacatgcga aaaaaactaa      300

agtgcgcgca tttcacggcc gaggggggtc ccacttggga ctgagagggg gtgggatctg      360

aaatcgagga ggtatcaaga ccccccgttt ctcaactccc taatcaaaaa ttacgaagtc      420

ctcgttggaa aggagttaaa ataattaagc ggggtcggac gccataccga ggttatcttg      480

caggcatttt actaatattg gaattcggag ctcaacttgc aaccaggcag ggtttagcta      540

tgtaatcaat gtaatcaata taataaagca ctaccacatc gaaggtttgg gagggaggcc      600

aatagtgtcc cccacagggt gctgatatcg cgattcttgg gtgaggagac acatatttca      660

ctcctctcac caaccaacca agcggctcct cgcaagatga tttatccgat tatccggaca      720

ctatactccc atccagtttg atgccgattt catcgattgt cctaaataat ccttaaatat      780

gtatagaacg gtaccctggg gttacataat ccttatttaa taatccctcc cccaccgctt      840

ttcttttttt ttcttcttat tgtc                                             864


<210>  33
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  33
aaatggcaga aggatcagcc tggacgaagc aaccagttcc aactgctaag taaagaagat       60

gctagacgaa ggagacttca gaggtgaaaa gtttgcaaga agagagctgc gggaaataaa      120

ttttcaattt aaggacttga gtgcgtccat attcgtgtac gtgtccaact gttttccatt      180

acctaagaaa aacataaaga ttaaaaagat aaacccaatc gggaaacttt agcgtgccgt      240

ttcggattcc gaaaaacttt tggagcgcca gatgactatg gaaagaggag tgtaccaaaa      300

tggcaagtcg ggggctactc accggatagc caatacattc tctaggaacc agggatgaat      360

ccaggttttt gttgtcacgg taggtcaagc attcacttct taggaatatc tcgttgaaag      420

ctacttgaaa tcccattggg tgcggaacca gcttctaatt aaatagttcg atgatgttct      480

ctaagtggga ctctacggct caaacttcta cacagcatca tcttagtagt cccttcccaa      540

aacaccattc taggtttcgg aacgtaacga aacaatgttc ctctcttcac attgggccgt      600

tactctagcc ttccgaagaa ccaataaaag ggaccggctg aaacgggtgt ggaaactcct      660

gtccagttta tggcaaaggc tacagaaatc ccaatcttgt cgggatgttg ctcctcccaa      720

acgccatatt gtactgcagt tggtgcgcat tttagggaaa atttacccca gatgtcctga      780

ttttcgaggg ctacccccaa ctccctgtgc ttatacttag tctaattcta ttcagtgtgc      840

tgacctacac gtaatgatgt cgtaacccag ttaaatggcc gaaaaactat ttaagtaagt      900

ttatttctcc tccagatgag actctccttc ttttctccgc tagttatcaa actataaacc      960

tattttacct caaatacctc caacatcacc cacttaaaca                           1000


<210>  34
<211>  549
<212>  DNA
<213>  Pichia pastoris

<400>  34
aatgatataa acaacaattg agtgacaggt ctactttgtt ctcaaaaggc cataaccatc       60

tgtttgcatc tcttatcacc acaccatcct cctcatctgg ccttcaattg tggggaacaa      120

ctagcatccc aacaccagac taactccacc cagatgaaac cagttgtcgc ttaccagtca      180

atgaatgttg agctaacgtt ccttgaaact cgaatgatcc cagccttgct gcgtatcatc      240

cctccgctat tccgccgctt gctccaacca tgtttccgcc tttttcgaac aagttcaaat      300

acctatcttt ggcaggactt ttcctcctgc cttttttagc ctcaggtctc ggttagcctc      360

taggcaaatt ctggtcttca tacctatatc aacttttcat cagatagcct ttgggttcaa      420

aaaagaacta aagcaggatg cctgatatat aaatcccaga tgatctgctt ttgaaactat      480

tttcagtatc ttgattcgtt tacttacaaa caactattgt tgattttatc tggagaataa      540

tcgaacaaa                                                              549


<210>  35
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  35
attactgttt tgggcaatcc tgttgataag acgcattcta gagttgtttc atgaaagggt       60

tacgggtgtt gattggtttg agatatgcca gaggacagat caatctgtgg tttgctaaac      120

tggaagtctg gtaaggactc tagcaagtcc gttactcaaa aagtcatacc aagtaagatt      180

acgtaacacc tgggcatgac tttctaagtt agcaagtcac caagagggtc ctatttaacg      240

tttggcggta tctgaaacac aagacttgcc tatcccatag tacatcatat tacctgtcaa      300

gctatgctac cccacagaaa taccccaaaa gttgaagtga aaaaatgaaa attactggta      360

acttcacccc ataacaaact taataatttc tgtagccaat gaaagtaaac cccattcaat      420

gttccgagat ttagtatact tgcccctata agaaacgaag gatttcagct tccttacccc      480

atgaacagaa atcttccatt taccccccac tggagagatc cgcccaaacg aacagataat      540

agaaaaaaga aattcggaca aatagaacac tttctcagcc aattaaagtc attccatgca      600

ctccctttag ctgccgttcc atccctttgt tgagcaacac catcgttagc cagtacgaaa      660

gaggaaactt aaccgatacc ttggagaaat ctaaggcgcg aatgagttta gcctagatat      720

ccttagtgaa gggttgttcc gatacttctc cacattcagt catagatggg cagctttgtt      780

atcatgaaga gacggaaacg ggcattaagg gttaaccgcc aaattatata aagacaacat      840

gtccccagtt taaagttttt ctttcctatt cttgtatcct gagtgaccgt tgtgtttaat      900

ataacaagtt cgttttaact taagaccaaa accagttaca acaaattata acccctctaa      960

acactaaagt tcactcttat caaactatca aacatcaaaa                           1000


<210>  36
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  36
gtcaactgcg tactcttttg tcgaatggac tactgaatct gcctcgatag ccactatagg       60

aaggtccata gaggccagtt tttcaactag tcttggtgga aagaaaccga caaagccttt      120

catggagtca ccgatactga aaggttcaaa caaagaatgc ttgggtagtc tcttaatacc      180

catggcaacg aaaaaggggt cttcattgtt caacatgaat tcgtatccac ctttaatgta      240

gtcataaagc tgctgaagtt ccgaatcagt gatggaactg tctacagtga caatatagga      300

gttctcaatc accttatatc cagtcgaata tatctggata gggtcgggtc tcactgtgga      360

agattcaaat gggttagatc cctgtaattt cagcgatgga gactcagtat gatggggcaa      420

ggaaaacggc aattggatat tcaattggtc aagagatggt atcaaaagcg agtgtgccag      480

ggtagccacg gtagccactg atgctaatct gataattttc atttctggag tgtcaaaaca      540

gtagtgataa aaggctatga aggaggttgt ctaggggctc gcggaggaaa gtgattcaaa      600

cagacctgcc aaaaagagaa aaaagaggga atccctgttc tttccaatgg aaatgacgta      660

actttaactt gaaaaatacc ccaaccagaa gggttcaaac tcaacaagga ttgcgtaatt      720

cctacaagta gcttagagct gggggagaga caactgaagg cagcttaacg ataacgcggg      780

gggattggtg cacgactcga aaggaggtat cttagtcttg taacctcttt tttccagagg      840

ctattcaaga ttcataggcg atatcgatgt ggagaagggt gaacaatata aaaggctgga      900

gagatgtcaa tgaagcagct ggatagattt caaattttct agatttcaga gtaatcgcac      960

aaaacgaagg aatcccacca agcaaaaaaa aaaatctaag                           1000


<210>  37
<211>  704
<212>  DNA
<213>  Pichia pastoris

<400>  37
aaattaatcc ataagataag gcaaatgtgc ttaagtaatt gaaaacagtg ttgtgattat       60

ataagcatgg tatttgaata gaactactgg ggttaactta tctagtagga tggaagttga      120

gggagatcaa gatgcttaaa gaaaaggatt ggccaatatg aaagccataa ttagcaatac      180

ttatttaatc agataattgt ggggcattgt gacttgactt ttaccaggac ttcaaacctc      240

aaccatttaa acagttatag aagacgtacc gtcacttttg cttttaatgt gatctaaatg      300

tgatcacatg aactcaaact aaaatgatat cttttactgg acaaaaatgt tatcctgcaa      360

acagaaagct ttcttctatt ctaagaagaa catttacatt ggtgggaaac ctgaaaacag      420

aaaataaata ctccccagtg accctatgag caggattttt gcatccctat tgtaggcctt      480

tcaaactcac acctaatatt tcccgccact cacactatca atgatcactt cccagttctc      540

ttcttcccct attcgtacca tgcaaccctt acacgccttt tccatttcgg ttcggatgcg      600

acttccagtc tgtggggtac gtagcctatt ctcttagccg gtatttaaac atacaaattc      660

acccaaattc taccttgata aggtaattga ttaatttcat aaat                       704


<210>  38
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  38
agctcagatt ggaaatgatt tttgatccta ccaagaagcc tttgatttcc agaatctccg       60

ctaagtaagt aacccccgca aacgcatgca tccatgcaaa caaaatacta acaattttag      120

ccccgttgtt gagaaaccca gaaaattgaa tgttcaacca atccagacga tcaataagaa      180

aaaaggccca aaggctactt ccaaacctgc tgccgccaaa cctgctcctt caaaagccgg      240

tcccaaggga ggtaagaagg tgagaaagcc aaagaagaca gttgaagaat tggatcagga      300

aatggctgac tactttgaaa ataagaatta gcccaacaaa atatgtacaa gtattatata      360

aatgaatcta catggtgtgt tttatttaga tcctccaaac caaggaaaga aactaaactt      420

atctccggac ttacgagtca aataactatc cgcagttcct tggaactcag actttcttcc      480

ataagcggtc atatcatctt tggactgtgg gaatcctgga cgaatctttg aaatgtcata      540

atcttgctct ctatctccaa gcacagcgtc cggtaaatgc tggttcttct ttctcagatg      600

aatcttggat ttaacaaata aagccgtgcc tatggctaat gtactcaaaa acaaagtctg      660

cttccagaat ttcgcaaacg atggaatgcc atttcctgta aatgtactca ttgaacctat      720

gtttgattaa agttggtgtg aagtcatcaa acgagagtaa aatcagatac tcgtgcaccg      780

gccaaaattg actgagctaa tctctgcagg cttgacatcc gaacacaaca aataggcgac      840

aaatcttaac tatctaatcg taggctatgg tagaactttg tgggggtaga ggaagactac      900

aacagcaaga caaaacaaaa gagtcatagt ttgactctct gcttttttct tctttctctt      960

ctttttcttc ctccatattc gttatttatt tcgaactgga                           1000


<210>  39
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  39
cagccattaa tctcacctca gtttttgaat cagtagaatt tttaatgaaa caaacggttg       60

gtatattatt tgatagagtt gccaaatttc caaagataaa tttttcatca ggtaatatcc      120

tgaataccgt aacatagtga ctattggaag acactgctat catattatat ttcggataaa      180

aatccaaacc ccagaccgac ctcttgagtc tcaactccaa gtcagccgca actttaatta      240

tccgtggatt gggagctagt ttggacaacg catcagtata atataacttt acggttccat      300

tatcagacgc tattgcaaga acttcctttc cattgatctc gccaatgcgg cagtaattga      360

tatcgtaggg taggtctgga aagacgctgg cgcttgtgtc ccattctgca ggaatctctg      420

gcacggtgct aatggtagtt atccaacgga gctgaggtag tcgatatatc tggatatgcc      480

gcctatagga taaaaacagg agagggtgaa ccttgcttat ggctactaga ttgttcttgt      540

actctgaatt ctcattatgg gaaactaaac taatctcatc tgtgtgttgc agtactattg      600

aatcgttgta gtatctacct ggagggcatt ccatgaatta gtgagataac agagttgggt      660

aactagagag aataatagac gtatgcatga ttactacaca acggatgtcg cactctttcc      720

ttagttaaaa ctatcatcca atcacaagat gcgggctgga aagacttgct cccgaaggat      780

aatcttctgc ttctatctcc cttcctcata tggtttcgca gggctcatgc cccttcttcc      840

ttcgaactgc ccgatgagga agtccttagc ctatcaaaga attcgggacc atcatcgatt      900

tttagagcct tacctgatcg caatcaggat ttcactactc atataaatac atcgctcaaa      960

gctccaactt tgcttgttca tacaattctt gatattcaca                           1000


<210>  40
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  40
tggttccctc tcggtccaat accaaaaata ttatcaccat acaggtctcc cttcgatacc       60

agtgcaaagt tgaaccgtgg gattaccttg gaatctacaa aaatagtgtc actcacaagt      120

ttgtcatcaa ccacgctgcc gcttgcaaag gagaactgaa catgaaggtt gttagggttt      180

gttatattgg aataagtggt ggatttgttg aaggcgaacg caccaaagct acatccgtcc      240

tgagcacact gtgaatttgt cacggaattg accaagaggt cagacgatcc tgtatcccat      300

tgagccgtta tgctttgtgg gggaaaccct atttctatcg tactaagaaa accaatggtg      360

aactcatatt cggtatcaat ggcgacgatt ccagcatagc ctgtagacag taacaacact      420

agggcaacag caactaacat atcttcattg atgaaacgtt gtgatcggtg tgacttttat      480

agtaaaagct acaactgttt gaaataccaa gatatcattg tgaatggctc aaaagggtaa      540

tacatctgaa aaacctgaag tgtggaaaat tccgatggag ccaactcatg ataacgcaga      600

agtcccattt tgccatcttc tcttggtatg aaacggtaga aaatgatccg agtatgccaa      660

ttgatactct tgattcatgc cctatagttt gcgtagggtt taattgatct cctggtctat      720

cgatctggga cgcaatgtag accccattag tggaaacact gaaagggatc caacactcta      780

ggcggacccg ctcacagtca tttcaggaca atcaccacag gaatcaacta cttctcccag      840

tcttccttgc gtgaagcttc aagcctacaa cataacactt cttacttaat ctttgattct      900

cgaattgttt acccaatctt gacaacttag cctaagcaat actctggggt tatatatagc      960

aattgctctt cctcgctgta gcgttcattc catctttcta                           1000


<210>  41
<211>  1001
<212>  DNA
<213>  Pichia pastoris

<400>  41
gatatcgatc tacacttaat agtagatgac gaggcatctc tccaataggt accatatctg       60

gtgtttcttg taatttaaga atctgttggt ctatgaatgt agatttgtca tgaacaatga      120

tatatgggtc aggaggacaa gatggtttct ctgagttggg ttgttgaggt gcctggcaag      180

acttcggagc gttgatatcc ccaagacttg tagtgaccga tagttgaagc gtgtgtttgc      240

aggaacggca catcaatgca actttcgtaa ctttggaatt gagagttgat gcactgatga      300

cgatacccga aattttgacg attttaccaa tatgacttga agacaagtct ctcattgaaa      360

ccttattatc gttactaagc aaaacgagct gacaagaagg gaaggtggtc ggtatttcct      420

cgttgttcaa atatatgatt ctcctggcaa tatctgtgat ggcctgttca aaaagtggaa      480

tcatttctgc aggatcatct accaactttt tattgagctc ctcattgaat acgattaagt      540

ggtcattttg aatcgtcagt aagtacttgt ttacaagtaa attctgtctg agttgttctc      600

tgtagatgta ctgattttcc atacgaaact ccaaaatgaa cgaacggaat gccttaatga      660

cctcactgaa ctggtcatcg ttctgttctc cgggaaggac acttgtgtta aagactgatg      720

ctctatcaaa ggacattgca acaaagtata aacggttgtg agcgggaaaa agatgtgtag      780

gtaattgtcg tagatgagac tgattcagta gaaaacgcgt cctgcactat ttttttcttt      840

cttcattaca tttcctaatc gggacaaaat gaatctaaag acgtggttat gtagtacacg      900

catcgatagg ctatccccat accaaaacac tattttaccc catccttgac aggttataaa      960

tatgcgatag tatgagtatc ttcaaattca gctgaaatat c                         1001


<210>  42
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  42
aataaaaaaa cgttatagaa agaaattgga ctacgatatg ctccaatcca aattgtcaaa       60

attgaccacc gaaaaagaac aattggaatt tgacaagagg aacaactcac tagattctca      120

aacggagcgt cacctagagt cagtttccaa gtcaattaca gaaagtttgg aaacagaaga      180

ggagtatcta caattgaatt ccaaacttaa agtcgagctg tccgaattca tgtcgctaag      240

gctttcttac ttggacccca tttttgaaag tttcattaaa gttcagtcaa aaattttcat      300

ggacatttat gacacattaa agagcggact accttatgtt gattctctat ccaaagagga      360

ttatcagtcc aagatcttgg actctagaat agataacatt ctgtcgaaaa tggaagcgct      420

gaaccttcaa gcttacattg atgattagag caatgatata aacaacaatt gagtgacagg      480

tctactttgt tctcaaaagg ccataaccat ctgtttgcat ctcttatcac cacaccatcc      540

tcctcatctg gccttcaatt gtggggaaca actagcatcc caacaccaga ctaactccac      600

ccagatgaaa ccagttgtcg cttaccagtc aatgaatgtt gagctaacgt tccttgaaac      660

tcgaatgatc ccagccttgc tgcgtatcat ccctccgcta ttccgccgct tgctccaacc      720

atgtttccgc ctttttcgaa caagttcaaa tacctatctt tggcaggact tttcctcctg      780

ccttttttag cctcaggtct cggttagcct ctaggcaaat tctggtcttc atacctatat      840

caacttttca tcagatagcc tttgggttca aaaaagaact aaagcaggat gcctgatata      900

taaatcccag atgatctgct tttgaaacta ttttcagtat cttgattcgt ttacttacaa      960

acaactattg ttgattttat ctggagaata atcgaacaaa                           1000


<210>  43
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  43
attgttgtga atactctcct tcatttggat ttcttggact tcggactctc ttgatctctc       60

ttcgaaagtt ttaactctgt tcatgtataa ttttacccgc tgtaggtcgc tcataatacc      120

atgagtatgc acatctttta ctccattaac tttcaggtat gcaaaataca atgaagatag      180

tatatagctc aaagaattta gcattttgca ttgatctaat tgtgacattt tctctatgat      240

atcatctagc ttcttaaact cgagaatctc gtccaacgag gcagaaacat tgtccagtct      300

tacgtcaaga ttattcacga gtttctggac cgtatcaacg ttttccatct taagattaca      360

gtaagtatcg tccttttgaa ctgcaaaggt agaaaagtta atttttgatt tggtagtaca      420

ctatgaaact tgctcacccc aatctttcct cctgacaggt tgatctttat ccctctacta      480

aattgcccca agtgtatcaa gtagactaga tctcgcgaaa gaacagccta ataaactccg      540

aagcatgatg gcctctatcc ggaaaacgtt aagagatgtg gcaacaggag ggcacataga      600

atttttaaag acgctgaaga atgctatcat agtccgtaaa aatgtgatag tactttgttt      660

agtgcgtacg ccacttattc ggggccaata gctaaaccca ggtttgctgg cagcaaattc      720

aactgtagat tgaatctctc taacaataat ggtgttcaat cccctggctg gtcacgggga      780

ggactatctt gcgtgatccg cttggaaaat gttgtgtatc cctttctcaa ttgcggaaag      840

catctgctac ttcccatagg caccagttac ccaattgata tttccaaaaa agattaccat      900

atgttcatct agaagtataa atacaagtgg acattcaatg aatatttcat tcaattagtc      960

attgacactt tcatcaactt actacgtctt attcaacaat                           1000


<210>  44
<211>  1000
<212>  DNA
<213>  Pichia pastoris

<400>  44
tatacggtct atccactttg gaaacgatgt agttgaaacg gggaagtaat agtggttccc       60

aaacgacatg aagaggttat ataagtttgc aagagggtga caccatttta gttgtggttc      120

ccgggtattt ttttaatctt tttagtctaa gatagcctcc ccagatatta ccgagttggg      180

ccatttgggg cggtatcggt ggtatctgat ggtagcgcgt ttttacatgc ctgtgcattg      240

aactggcaaa gagtatacta tcgtggggcc ctgaaggagg cagcaaatgg accgtcaatt      300

ggttgatcag ggactcaaga caggtattga gcttttcaaa caaaaagagt ataggcgctg      360

ctacaaggca tttacttcta ctatcaattt cattgagaat gatcccgagt tggccgccag      420

ctgtgtatct caactgatat ctctgttaga ttgtagggca gcctgtttgg aaaagctaga      480

tcaattgaat atggccttga aagatggtct taaaatgatc aagagagagt gccacaactg      540

caagggttat ttgagaactt gcaaaatttt agacctacaa gggaagatca gtgaggcttt      600

gtctacagca agagaaggga tctccataat agaaactaga agagatcagg ataatcaatt      660

tagatattcc aaggttcttt tggaacaatt aaaggaactg aaaaatgcac tgaaaatcaa      720

attggacaag aaaaatcagc tacacttcaa agttttaaag tttgacgcac cagtgccttg      780

tacaaagaaa ctaagattag tcactccaag aacaatagat ccttccattt ttttgccgat      840

agagctagtg aagctgatct ttcgcctgtt gaatttctca gacatgtatg cctgtttatt      900

ggtctcaaca aaatggaact caattatatc ctcatcaccg gaactgtttc gaaaacttca      960

gttgaaatcc caactgtcca acaaggcgtt aaacaattgt                           1000


<210>  45
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pG1 promoter


<220>
<221>  misc_feature
<222>  (578)..(578)
<223>  n is (T)x wherein x is 14-16

<400>  45
caaacatttg ctccccctag tctccaggga aatgtaaaat atactgctaa tagaaaacag       60

taagacgctc agttgtcagg ataattacgt tcgactgtag taaaacagga atctgtattg      120

ttagaaagaa cgagagtttt ttacggcgcc gccatattgg gccgtgtgaa aacagcttga      180

aaccccacta ctttcaaagg ttctgttgct atacacgaac catgtttaac caacctcgct      240

tttgacttga ctgaagtcat cggttaacaa tcaagtaccc tagtctgtct gaatgctcct      300

ttccatattc agtaggtgtt tcttgcactt ttgcatgcac tgcggaagaa ttagccaata      360

gcgcgtttca tatgcgcttt taccccctct tttgtcaagc gcaaaatgcc tgtaagattt      420

ggtgggggtg tgagccgtta gctgaagtac aacaggctaa ttccctgaaa aaactgcaga      480

tagacttcaa gatctcaggg attcccacta tttggtattc tgatatgttt ttcctgatat      540

gcatcaaaac tctaatctaa aacctgaatc tccgctanga tgaccccgtt ttcgtgacaa      600

attaatttcc aacggggtct tgtccggata agagaatttt gtttgattat ccgttcggat      660

aaatggacgc ctgctccata tttttccggt tattacccca cctggaagtg cccagaattt      720

tccggggatt acggataata cggtggtctg gattaattaa tacgccaagt cttacatttt      780

gttgcagtct cgtgcgagta tgtgcaataa taaacaagat gagccaattt attggattag      840

ttgcagcttg accccgccat agctaggcat agccaagtgc tatgggtgtt agatgatgca      900

cttggatgca gtgagttttg gagtataaaa gatccttaaa attccaccct t               951


<210>  46
<211>  1238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pG1-3 promoter

<400>  46
caaacatttg ctccccctag tctccaggga aatgtaaaat atactgctaa tagaaaacag       60

taagacgctc agttgtcagg ataattacgt tcgactgtag taaaacagga atctgtattg      120

ttagaaagaa cgagagtttt ttacggcgcc gccatattgg gccgtgtgaa aacagcttga      180

aaccccacta ctttcaaagg ttctgttgct atacacgaac catgtttaac caacctcgct      240

tttgacttga ctgaagtcat cggttaacaa tcaagtaccc tagtctgtct gaatgctcct      300

ttccatattc agtaggtgtt tcttgcactt ttgcatgcac tgcggaagaa ttagccaata      360

gcgcgtttca tatgcgcttt taccccctct tttgtcaagc gcaaaatgcc tgtaagattt      420

ggtgggggtg tgagccgtta gctgaagtac aacaggctaa ttccctgaaa aaactgcagc      480

tcagggattc ccactatttg gtattctgat atgtttttcc tgatatgcat caaaactcta      540

atctaaaacc tgaatctccg ctattttttt tttttttgat gaccccgttt tcgtgacaaa      600

ttaatttcca acggggtctt gtccggataa gagaattttg tttgattatc cgttcggata      660

aatggacgcc tgctccatat ttttccggtt attaccccac ctggaagtgc ccagaatttt      720

ccggggatta cggataatac ggtggtctgg attaattaat acgagatctc agggattccc      780

actatttggt attctgatat gtttttcctg atatgcatca aaactctaat ctaaaacctg      840

aatctccgct attttttttt tttttgatga ccccgttttc gtgacaaatt aatttccaac      900

ggggtcttgt ccggataaga gaattttgtt tgattatccg ttcggataaa tggacgcctg      960

ctccatattt ttccggttat taccccacct ggaagtgccc agaattttcc ggggattacg     1020

gataatacgg tggtctggat taattaatac gccaagtctt acattttgtt gcagtctcgt     1080

gcgagtatgt gcaataataa acaagatgag ccaatttatt ggattagttg cagcttgacc     1140

ccgccatagc taggcatagc caagtgctat gggtgttaga tgatgcactt ggatgcagtg     1200

agttttggag tataaaagat ccttaaaatt ccaccctt                             1238


<210>  47
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pG1-4 promoter

<400>  47
caaacatttg ctccccctag tctccaggga aatgtaaaat atactgctaa tagaaaacag       60

taagacgctc agttgtcagg ataattacgt tcgactgtag taaaacagga atctgtattg      120

ttagaaagaa cgagagtttt ttacggcgcc gccatattgg gccgtgtgaa aacagcttga      180

aaccccacta ctttcaaagg ttctgttgct atacacgaac catgtttaac caacctcgct      240

tttgacttga ctgaagtcat cggttaacaa tcaagtaccc tagtctgtct gaatgctcct      300

ttccatattc agtaggtgtt tcttgcactt ttgcatgcac tgcggaagaa ttagccaata      360

gcgcgtttca tatgcgcttt taccccctct tttgtcaagc gcaaaatgcc tgtaagattt      420

ggtgggggtg tgagccgtta gctgaagtac aacaggctaa ttccctgaaa aaactgcagc      480

tcagggattc ccactatttg gtattctgat atgtttttcc tgatatgcat caaaactcta      540

atctaaaacc tgaatctccg ctattttttt tttttttgat gaccccgttt tcgtgacaaa      600

ttaatttcca acggggtctt gtccggataa gagaattttg tttgattatc cgttcggata      660

aatggacgcc tgctccatat ttttccggtt attaccccac ctggaagtgc ccagaatttt      720

ccggggatta cggataatac ggtggtctgg attaattaat acgccaagtc ttacattttg      780

ttgcagtctc gtgcgagtat gtgcaataat aaacaagatg agccaattta ttggattagt      840

tgcagcttga ccccgccata gctaggcata gccaagtgct atgggtgtta gatgatgcac      900

ttggatgcag tgagttttgg agtataaaag atccttaaaa ttccaccctt agatctcagg      960

gattcccact atttggtatt ctgatatgtt tttcctgata tgcatcaaaa ctctaatcta     1020

aaacctgaat ctccgctatt tttttttttt ttgatgaccc cgttttcgtg acaaattaat     1080

ttccaacggg gtcttgtccg gataagagaa ttttgtttga ttatccgttc ggataaatgg     1140

acgcctgctc catatttttc cggttattac cccacctgga agtgcccaga attttccggg     1200

gattacggat aatacggtgg tctggattaa ttaatacgcc aagtcttaca ttttgttgca     1260

gtctcgtgcg agtatgtgca ataataaaca agatgagcca atttattgga ttagttgcag     1320

cttgaccccg ccatagctag gcatagccaa gtgctatggg tgttagatga tgcacttgga     1380

tgcagtgagt tttggagtat aaaagatcct taaaattcca ccctt                     1425


<210>  48
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain sequence

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Phe Asp Ala Asp Met Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220         


<210>  49
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain sequence

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asn Asn Ser 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  50
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain sequence

<400>  50

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Lys Phe Pro Gly Asn Arg Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Val Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Asp Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Asn Trp Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215             


<210>  51
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain sequence

<400>  51

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asn Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  52
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
tactaatatt acctttacag aattctttcc actcctccaa tgttttagtt agaggtgccg       60

atgatggtag agacttctac aagatcttg                                         89


