               SEQUENCE LISTING

<110> Sanofi

<120> Split CH2 Domains

<130> 589-319 PCT

<150> EP20315072.7
<151> 2020-03-30

<160> 48

<170> BiSSAP 1.3.6

<210> 1
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal consensus N-term

<220> 
<221> VARIANT
<222> 31
<223> any amino acid

<220> 
<221> VARIANT
<222> 37
<223> any amino acid

<220> 
<221> VARIANT
<222> 39
<223> any amino acid

<400> 1
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Xaa Glu 
            20                  25                  30          
Asp Pro Glu Val Xaa Phe Xaa Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              
Asn 
    

<210> 2
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal consensus C-term

<220> 
<221> VARIANT
<222> 4
<223> any amino acid

<220> 
<221> VARIANT
<222> 13
<223> any amino acid

<220> 
<221> VARIANT
<222> 31
<223> any amino acid

<220> 
<221> VARIANT
<222> 34
<223> any amino acid

<220> 
<221> VARIANT
<222> 35
<223> any amino acid

<400> 2
Asn Ser Thr Xaa Arg Val Val Ser Val Leu Thr Val Xaa His Gln Asp 
1               5                   10                  15      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Xaa Leu 
            20                  25                  30          
Pro Xaa Xaa Ile Glu Lys Thr Ile 
        35                  40  

<210> 3
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal N-term IgG1

<400> 3
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              
Asn 
    

<210> 4
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal C-term IgG1

<400> 4
Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
1               5                   10                  15      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            20                  25                  30          
Pro Ala Pro Ile Glu Lys Thr Ile 
        35                  40  

<210> 5
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal N-term IgG2

<400> 5
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            20                  25                  30          
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              
Asn 
    

<210> 6
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal C-term IgG2

<400> 6
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
1               5                   10                  15      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            20                  25                  30          
Pro Ser Ser Ile Glu Lys Thr Ile 
        35                  40  

<210> 7
<211> 49
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal N-term IgG3

<400> 7
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              
Asn 
    

<210> 8
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal C-term IgG3

<400> 8
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
1               5                   10                  15      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            20                  25                  30          
Pro Ala Pro Ile Glu Lys Thr Ile 
        35                  40  

<210> 9
<211> 48
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal N-term IgG4

<400> 9
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
1               5                   10                  15      
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            20                  25                  30          
Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn 
        35                  40                  45              



<210> 10
<211> 40
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal C-term IgG4

<400> 10
Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
1               5                   10                  15      
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            20                  25                  30          
Pro Ala Pro Ile Glu Lys Thr Ile 
        35                  40  

<210> 11
<211> 293
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GGGSGGGG_IL4VH_CH2(N)

<400> 11
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
        115                 120                 125             
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
    130                 135                 140                 
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro 
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu 
                165                 170                 175     
Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp 
            180                 185                 190         
Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu 
        195                 200                 205             
Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr 
    210                 215                 220                 
Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val 
225                 230                 235                 240 
Ser Ser Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             
Val Glu Val His Asn 
    290             

<210> 12
<211> 308
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGSGGGG_IL13VH_GGGGSGGGGS_CH2(C)_[His6]

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
        115                 120                 125             
Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    130                 135                 140                 
Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
145                 150                 155                 160 
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
                165                 170                 175     
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
            180                 185                 190         
Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
        195                 200                 205             
Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
    210                 215                 220                 
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        275                 280                 285             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu His His 
    290                 295                 300                 
His His His His 
305             

<210> 13
<211> 386
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GGGGSGGGGS_IL4VL_IGKC_CH2(N)

<400> 13
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
        115                 120                 125             
Pro Ala Ser Leu Ser Val Ser Val Gly Asp Thr Ile Thr Leu Thr Cys 
    130                 135                 140                 
His Ala Ser Gln Asn Ile Asp Val Trp Leu Ser Trp Phe Gln Gln Lys 
145                 150                 155                 160 
Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His 
                165                 170                 175     
Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe 
            180                 185                 190         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
        195                 200                 205             
Cys Gln Gln Ala His Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys 
    210                 215                 220                 
Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                245                 250                 255     
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            260                 265                 270         
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        275                 280                 285             
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    290                 295                 300                 
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
305                 310                 315                 320 
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
                325                 330                 335     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            340                 345                 350         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        355                 360                 365             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    370                 375                 380                 
His Asn 
385     

<210> 14
<211> 424
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VH_GGGGSGGGGS_IL4VH_CH1_GGG_CH2(C)_[His]6

<400> 14
Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser 
            20                  25                  30          
Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
145                 150                 155                 160 
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                165                 170                 175     
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
            180                 185                 190         
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
        195                 200                 205             
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
225                 230                 235                 240 
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                245                 250                 255     
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            260                 265                 270         
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        275                 280                 285             
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    290                 295                 300                 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
305                 310                 315                 320 
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                325                 330                 335     
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            340                 345                 350         
Ser Cys Asp Lys Gly Gly Gly Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        355                 360                 365             
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    370                 375                 380                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
385                 390                 395                 400 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                405                 410                 415     
Arg Glu His His His His His His 
            420                 

<210> 15
<211> 391
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GQPKAAPS_IL4VL_TKGPSVF_IGKC_CH2(N)

<400> 15
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gln Pro Lys Ala Ala Pro Ser Asp Ile Gln Met Thr Gln Ser Pro Ala 
        115                 120                 125             
Ser Leu Ser Val Ser Val Gly Asp Thr Ile Thr Leu Thr Cys His Ala 
    130                 135                 140                 
Ser Gln Asn Ile Asp Val Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly 
145                 150                 155                 160 
Asn Ile Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly 
                165                 170                 175     
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu 
            180                 185                 190         
Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
        195                 200                 205             
Gln Ala His Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu 
    210                 215                 220                 
Ile Lys Thr Lys Gly Pro Ser Val Phe Arg Thr Val Ala Ala Pro Ser 
225                 230                 235                 240 
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                245                 250                 255     
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            260                 265                 270         
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        275                 280                 285             
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    290                 295                 300                 
Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
305                 310                 315                 320 
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                325                 330                 335     
Arg Gly Glu Cys Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            340                 345                 350         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        355                 360                 365             
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    370                 375                 380                 
Asp Gly Val Glu Val His Asn 
385                 390     

<210> 16
<211> 415
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VH_S_IL13VH_CH1_GGG_CH2(C)_[His]6

<400> 16
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ser Glu Val Gln Leu 
        115                 120                 125             
Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly Ser Leu Ser Ile 
    130                 135                 140                 
Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser Ser Ile Asn Trp 
145                 150                 155                 160 
Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp 
                165                 170                 175     
Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys Ser Arg Leu Ser 
            180                 185                 190         
Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu Glu Met Thr Ser 
        195                 200                 205             
Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Tyr 
    210                 215                 220                 
Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                245                 250                 255     
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            260                 265                 270         
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        275                 280                 285             
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    290                 295                 300                 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
305                 310                 315                 320 
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                325                 330                 335     
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Gly Gly Gly Ala Lys 
            340                 345                 350         
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 
Ser Lys Ala Lys Gly Gln Pro Arg Glu His His His His His His 
                405                 410                 415 

<210> 17
<211> 284
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_CH2(N)_GGGGSGGGGSGGGGS_IL4VL

<400> 17
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    130                 135                 140                 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
145                 150                 155                 160 
His Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     
Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val 
            180                 185                 190         
Gly Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val 
        195                 200                 205             
Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu 
    210                 215                 220                 
Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser 
225                 230                 235                 240 
Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                245                 250                 255     
Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro 
            260                 265                 270         
Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        275                 280                 

<210> 18
<211> 321
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VH_GGGGSGGGGSGGGGS_CH2(C)_IL4VH_[His]6

<400> 18
Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser 
            20                  25                  30          
Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    130                 135                 140                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
        195                 200                 205             
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
    210                 215                 220                 
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
225                 230                 235                 240 
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
                245                 250                 255     
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
            260                 265                 270         
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
        275                 280                 285             
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
    290                 295                 300                 
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser His His His His His 
305                 310                 315                 320 
His 
    

<210> 19
<211> 269
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_CH2(N)_IL4VL

<400> 19
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    130                 135                 140                 
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
145                 150                 155                 160 
His Asn Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser 
                165                 170                 175     
Val Gly Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp 
            180                 185                 190         
Val Trp Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu 
        195                 200                 205             
Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe 
    210                 215                 220                 
Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 
Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr 
                245                 250                 255     
Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 

<210> 20
<211> 309
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VH_GGG_CH2(C)_IL4VH_[His]6

<400> 20
Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser 
            20                  25                  30          
Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     
Gln Pro Arg Glu Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            180                 185                 190         
Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
        195                 200                 205             
Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly 
    210                 215                 220                 
Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu 
225                 230                 235                 240 
Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr 
                245                 250                 255     
Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala 
            260                 265                 270         
Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe 
        275                 280                 285             
Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser His 
    290                 295                 300                 
His His His His His 
305                 

<210> 21
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGSGGGG_IL13VH_CH2(C)_GGGSGSA_IgG4-Fc(PE)

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
        115                 120                 125             
Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    130                 135                 140                 
Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
145                 150                 155                 160 
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
                165                 170                 175     
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
            180                 185                 190         
Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
        195                 200                 205             
Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
    210                 215                 220                 
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        275                 280                 285             
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Gly Gly 
    290                 295                 300                 
Gly Ser Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
305                 310                 315                 320 
Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                325                 330                 335     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            340                 345                 350         
Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        355                 360                 365             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    370                 375                 380                 
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
385                 390                 395                 400 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                405                 410                 415     
Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            420                 425                 430         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        435                 440                 445             
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    450                 455                 460                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
465                 470                 475                 480 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                485                 490                 495     
Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
            500                 505                 510         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        515                 520                 525             
Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    530                 535         

<210> 22
<211> 653
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VH_GGGGSGGGGS_IL4VH_CH1_GGG_CH2(C)_GGGSGSA_IgG4-Fc(PE)

<400> 22
Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser 
            20                  25                  30          
Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
145                 150                 155                 160 
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
                165                 170                 175     
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
            180                 185                 190         
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
        195                 200                 205             
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
225                 230                 235                 240 
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                245                 250                 255     
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            260                 265                 270         
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        275                 280                 285             
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    290                 295                 300                 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
305                 310                 315                 320 
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                325                 330                 335     
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            340                 345                 350         
Ser Cys Asp Lys Gly Gly Gly Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        355                 360                 365             
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    370                 375                 380                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
385                 390                 395                 400 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                405                 410                 415     
Arg Glu Gly Gly Gly Ser Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 
            420                 425                 430         
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
        435                 440                 445             
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    450                 455                 460                 
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
465                 470                 475                 480 
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                485                 490                 495     
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            500                 505                 510         
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        515                 520                 525             
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    530                 535                 540                 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
545                 550                 555                 560 
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                565                 570                 575     
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            580                 585                 590         
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        595                 600                 605             
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    610                 615                 620                 
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
625                 630                 635                 640 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
                645                 650             

<210> 23
<211> 644
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VH_S_IL13VH_CH1_GGG_CH2(C)_GGGSGSA_IgG4-Fc(PE)

<400> 23
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Ser Glu Val Gln Leu 
        115                 120                 125             
Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly Ser Leu Ser Ile 
    130                 135                 140                 
Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser Ser Ile Asn Trp 
145                 150                 155                 160 
Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp 
                165                 170                 175     
Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys Ser Arg Leu Ser 
            180                 185                 190         
Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu Glu Met Thr Ser 
        195                 200                 205             
Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Tyr 
    210                 215                 220                 
Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                245                 250                 255     
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            260                 265                 270         
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        275                 280                 285             
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    290                 295                 300                 
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
305                 310                 315                 320 
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                325                 330                 335     
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Gly Gly Gly Ala Lys 
            340                 345                 350         
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Gly Gly Gly Ser Gly Ser Ala 
                405                 410                 415     
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
            420                 425                 430         
Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        435                 440                 445             
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    450                 455                 460                 
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
465                 470                 475                 480 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                485                 490                 495     
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            500                 505                 510         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        515                 520                 525             
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    530                 535                 540                 
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
545                 550                 555                 560 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                565                 570                 575     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            580                 585                 590         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        595                 600                 605             
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    610                 615                 620                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
625                 630                 635                 640 
Leu Ser Leu Gly 
                

<210> 24
<211> 444
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13_IgG4-Fc(PE)_holes_RF

<400> 24
Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser 
            20                  25                  30          
Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys 
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  
Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 

<210> 25
<211> 160
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GG_CH2(N)

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Pro 
            100                 105                 110         
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        115                 120                 125             
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    130                 135                 140                 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
145                 150                 155                 160 



<210> 26
<211> 429
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VH_GGGGGSGGGGGS_CH2(C)_GGGSGSA_IgG4-Fc(PE)_knobs

<400> 26
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Gly Ser Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    130                 135                 140                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
145                 150                 155                 160 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                165                 170                 175     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            180                 185                 190         
Arg Glu Gly Gly Gly Ser Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 
        195                 200                 205             
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
    210                 215                 220                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
225                 230                 235                 240 
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
                245                 250                 255     
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            260                 265                 270         
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
        275                 280                 285             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    290                 295                 300                 
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
305                 310                 315                 320 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                325                 330                 335     
Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
            340                 345                 350         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        355                 360                 365             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    370                 375                 380                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
385                 390                 395                 400 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                405                 410                 415     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            420                 425                 

<210> 27
<211> 218
<212> PRT
<213> Artificial Sequence


<220> 
<223> Il13LC

<400> 27
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 28
<211> 413
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGGGSGGGGGS_CH2(C)_GGGSGSA_ IgG4-Fc(PE)_knobs

<400> 28
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Gly 
            100                 105                 110         
Ser Gly Gly Gly Gly Gly Ser Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        115                 120                 125             
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    130                 135                 140                 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
145                 150                 155                 160 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                165                 170                 175     
Arg Glu Gly Gly Gly Ser Gly Ser Ala Glu Ser Lys Tyr Gly Pro Pro 
            180                 185                 190         
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
        195                 200                 205             
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    210                 215                 220                 
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
225                 230                 235                 240 
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                245                 250                 255     
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            260                 265                 270         
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        275                 280                 285             
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    290                 295                 300                 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
305                 310                 315                 320 
Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
                325                 330                 335     
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            340                 345                 350         
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        355                 360                 365             
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    370                 375                 380                 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
385                 390                 395                 400 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                405                 410             

<210> 29
<211> 176
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VH_GG_CH2(N)

<400> 29
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asp Gly Glu Thr Arg Leu Asn Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Ala Thr Leu Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Arg Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Leu Lys Glu Tyr Gly Asn Tyr Asp Ser Phe Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Ala Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Pro 
        115                 120                 125             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     



<210> 30
<211> 51
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-term

<400> 30
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              
Val His Asn 
    50      

<210> 31
<211> 59
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-term

<400> 31
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
1               5                   10                  15      
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            20                  25                  30          
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        35                  40                  45              
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    50                  55                  

<210> 32
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Leader Sequence (used in all constructs) Aa 1-19 from Mouse Ig
      heavy chain V region 102 (UniProt P01750)

<400> 32
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210> 33
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> CH2_[His]6

<400> 33
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10                  15      
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
65                  70                  75                  80  
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                85                  90                  95      
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu His His 
            100                 105                 110         
His His His His 
        115     

<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<220> 
<221> VARIANT
<222> 1
<223> w-fold (0-20)

<220> 
<221> VARIANT
<222> 1..3
<223> z-fold (0-10)

<220> 
<221> VARIANT
<222> 2
<223> x-fold (0-10)

<220> 
<221> VARIANT
<222> 3
<223> y-fold (0-20)

<220> 
<221> VARIANT
<222> 4
<223> missing (only to satisfy minimum length "4" for seq listing, see
      features for other residues)

<400> 34
Gly Ser Gly Xaa 
1               

<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 35
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
1               5                   10          

<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 36
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 37
Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               

<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 38
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 39
Gly Gln Pro Lys Ala Ala Pro Ser 
1               5               

<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 40
Thr Lys Gly Pro Ser Val 
1               5       

<210> 41
<211> 288
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GGGSGGGG_IL4VH_GG_IgA-CH2(N)122-166

<400> 41
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
        115                 120                 125             
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
    130                 135                 140                 
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro 
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu 
                165                 170                 175     
Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp 
            180                 185                 190         
Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu 
        195                 200                 205             
Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr 
    210                 215                 220                 
Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val 
225                 230                 235                 240 
Ser Ser Gly Gly Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu 
                245                 250                 255     
Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr 
            260                 265                 270         
Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser 
        275                 280                 285             



<210> 42
<211> 308
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGSGGGG_IL13VH_GGGGSGGGGS_IgA-CH2(C)167-225_C180S_[His6]

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
        115                 120                 125             
Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    130                 135                 140                 
Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
145                 150                 155                 160 
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
                165                 170                 175     
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
            180                 185                 190         
Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
        195                 200                 205             
Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
    210                 215                 220                 
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg Asp Leu 
                245                 250                 255     
Ser Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala Glu Pro 
            260                 265                 270         
Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser 
        275                 280                 285             
Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr His His 
    290                 295                 300                 
His His His His 
305             

<210> 43
<211> 290
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GGGSGGGG_IL4VH_IgD-CH2(N)166-213

<400> 43
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
        115                 120                 125             
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
    130                 135                 140                 
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro 
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu 
                165                 170                 175     
Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp 
            180                 185                 190         
Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu 
        195                 200                 205             
Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr 
    210                 215                 220                 
Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val 
225                 230                 235                 240 
Ser Ser Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln Asp 
                245                 250                 255     
Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly Ser 
            260                 265                 270         
Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val Pro 
        275                 280                 285             
Thr Gly 
    290 

<210> 44
<211> 310
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGSGGGG_IL13VH_GGGGSGGGGS_IgD-CH2(C)214-274_[His6]

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
        115                 120                 125             
Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    130                 135                 140                 
Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
145                 150                 155                 160 
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
                165                 170                 175     
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
            180                 185                 190         
Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
        195                 200                 205             
Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
    210                 215                 220                 
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
                245                 250                 255     
Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
            260                 265                 270         
Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
        275                 280                 285             
Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
    290                 295                 300                 
His His His His His His 
305                 310 

<210> 45
<211> 291
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GGGSGGGG_IL4VH_IgE-CH3(N)215-263

<400> 45
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
        115                 120                 125             
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
    130                 135                 140                 
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro 
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu 
                165                 170                 175     
Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp 
            180                 185                 190         
Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu 
        195                 200                 205             
Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr 
    210                 215                 220                 
Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val 
225                 230                 235                 240 
Ser Ser Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp 
                245                 250                 255     
Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu 
            260                 265                 270         
Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly 
        275                 280                 285             
Lys Pro Val 
    290     

<210> 46
<211> 308
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGSGGGG_IL13VH_GGGGSGGGGS_IgE-CH3(C)264-322_[His6]

<400> 46
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
        115                 120                 125             
Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    130                 135                 140                 
Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
145                 150                 155                 160 
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
                165                 170                 175     
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
            180                 185                 190         
Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
        195                 200                 205             
Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
    210                 215                 220                 
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly 
                245                 250                 255     
Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile 
            260                 265                 270         
Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg 
        275                 280                 285             
Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala His His 
    290                 295                 300                 
His His His His 
305             

<210> 47
<211> 289
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL13VL_GGGSGGGG_IL4VH_IgE-CH2(N)110-156(C121S)

<400> 47
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          
Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  
Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      
Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Ser Gly Gly Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
        115                 120                 125             
Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
    130                 135                 140                 
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile His Trp Ile Lys Gln Arg Pro 
145                 150                 155                 160 
Gly Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Gly Glu 
                165                 170                 175     
Thr Arg Leu Asn Gln Arg Phe Gln Gly Arg Ala Thr Leu Thr Val Asp 
            180                 185                 190         
Glu Ser Thr Ser Thr Ala Tyr Met Gln Leu Arg Ser Pro Thr Ser Glu 
        195                 200                 205             
Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Lys Glu Tyr Gly Asn Tyr 
    210                 215                 220                 
Asp Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Leu Val Thr Val 
225                 230                 235                 240 
Ser Ser Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Ser Asp Gly 
                245                 250                 255     
Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly 
            260                 265                 270         
Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val 
        275                 280                 285             
Met 
    

<210> 48
<211> 301
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL4VL_GGGSGGGG_IL13VH_GGGGSGGGGS_IgE-CH2(C)157-208_[His6]

<400> 48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      
Asp Thr Ile Thr Leu Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          
Leu Ser Trp Phe Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         
Gly Gly Gly Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
        115                 120                 125             
Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
    130                 135                 140                 
Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
145                 150                 155                 160 
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
                165                 170                 175     
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
            180                 185                 190         
Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
        195                 200                 205             
Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
    210                 215                 220                 
Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Gly Ser Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly 
                245                 250                 255     
Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp 
            260                 265                 270         
Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr 
        275                 280                 285             
Phe Glu Asp Ser Thr Lys Lys His His His His His His 
    290                 295                 300     

