                         SEQUENCE LISTING

<110>  Pharis Biotec GmbH
 
<120>  Polypeptide for the prophylaxis and treatment of viral infections

<130>  210497WO

<140>  PCT/EP2021/058150

<141>  2021-03-29

<150>  EP20167370.4

<151>  2020-03-31

<150>  EP20184401.6

<151>  2020-07-07


<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  57
<212>  PRT
<213>  human

<400>  1

Lys Asn Glu Asp Gln Glu Met Cys His Glu Phe Gln Ala Phe Met Lys 
1               5                   10                  15      


Asn Gly Lys Leu Phe Cys Pro Gln Asp Lys Lys Phe Phe Gln Ser Leu 
            20                  25                  30          


Asp Gly Ile Met Phe Ile Asn Lys Cys Ala Thr Cys Lys Met Ile Leu 
        35                  40                  45              


Glu Lys Glu Ala Lys Ser Gln Lys Arg 
    50                  55          


<210>  2
<211>  76
<212>  PRT
<213>  human

<400>  2

Ala Arg His Leu Ala Arg Ala Pro Lys Ala Thr Ala Pro Thr Glu Leu 
1               5                   10                  15      


Asn Cys Asp Asp Phe Lys Lys Gly Glu Arg Asp Gly Asp Phe Ile Cys 
            20                  25                  30          


Pro Asp Tyr Tyr Glu Ala Val Cys Gly Thr Asp Gly Lys Thr Tyr Asp 
        35                  40                  45              


Asn Arg Cys Ala Leu Cys Ala Glu Asn Ala Lys Thr Gly Ser Gln Ile 
    50                  55                  60                  


Gly Val Lys Ser Glu Gly Glu Cys Lys Ser Ser Asn 
65                  70                  75      


<210>  3
<211>  64
<212>  PRT
<213>  human

<400>  3

Pro Glu Gln Asp Val Cys Ser Ala Phe Arg Pro Phe Val Arg Asp Gly 
1               5                   10                  15      


Arg Leu Gly Cys Thr Arg Glu Asn Asp Pro Val Leu Gly Pro Asp Gly 
            20                  25                  30          


Lys Thr His Gly Asn Lys Cys Ala Met Cys Ala Glu Leu Phe Leu Lys 
        35                  40                  45              


Glu Ala Glu Asn Ala Lys Arg Glu Gly Glu Thr Arg Ile Arg Arg Asn 
    50                  55                  60                  


<210>  4
<211>  64
<212>  PRT
<213>  human

<400>  4

Pro Glu Gln Asp Val Cys Ser Ala Phe Arg Pro Phe Val Arg Asp Gly 
1               5                   10                  15      


Arg Leu Gly Cys Thr Arg Glu Asn Asp Pro Val Cys Gly Pro Asp Gly 
            20                  25                  30          


Lys Thr His Gly Asn Lys Cys Ala Met Cys Ala Glu Leu Phe Leu Lys 
        35                  40                  45              


Glu Ala Glu Asn Ala Lys Arg Glu Gly Glu Thr Cys Ile Arg Arg Asn 
    50                  55                  60                  


<210>  5
<211>  72
<212>  PRT
<213>  human

<400>  5

Ala Glu Lys Asp Phe Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly 
1               5                   10                  15      


Arg Leu Phe Cys Thr Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly 
            20                  25                  30          


Arg Met His Gly Asn Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Gln 
        35                  40                  45              


Arg Phe Ser Glu Glu Asn Ser Lys Thr Asp Gln Asn Leu Gly Lys Ala 
    50                  55                  60                  


Glu Glu Lys Thr Lys Val Lys Arg 
65                  70          


<210>  6
<211>  72
<212>  PRT
<213>  human

<400>  6

Ala Glu Lys Asp Phe Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly 
1               5                   10                  15      


Arg Leu Phe Cys Thr Arg Glu Ser Asp Pro Val Cys Gly Pro Asp Gly 
            20                  25                  30          


Arg Met His Gly Asn Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Gln 
        35                  40                  45              


Arg Phe Ser Glu Glu Asn Ser Lys Thr Asp Gln Cys Leu Gly Lys Ala 
    50                  55                  60                  


Glu Glu Lys Thr Lys Val Lys Arg 
65                  70          


<210>  7
<211>  72
<212>  PRT
<213>  human

<400>  7

Ala Glu Lys Asp Phe Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly 
1               5                   10                  15      


Arg Leu Phe Cys Thr Arg Glu Ser Asp Pro Val Arg Gly Pro Asp Gly 
            20                  25                  30          


Arg Met His Gly Asn Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Arg 
        35                  40                  45              


Arg Phe Ser Glu Glu Asn Ser Lys Thr Asp Gln Asn Leu Gly Lys Ala 
    50                  55                  60                  


Glu Glu Lys Thr Lys Val Lys Arg 
65                  70          


<210>  8
<211>  72
<212>  PRT
<213>  human

<400>  8

Ala Glu Lys Asp Phe Cys Lys Glu Tyr Glu Lys Gln Val Arg Asn Gly 
1               5                   10                  15      


Arg Leu Phe Cys Thr Arg Glu Ser Asp Pro Val Cys Gly Pro Asp Gly 
            20                  25                  30          


Arg Met His Gly Asn Lys Cys Ala Leu Cys Ala Glu Ile Phe Lys Arg 
        35                  40                  45              


Arg Phe Ser Glu Glu Asn Ser Lys Thr Asp Gln Cys Leu Gly Lys Ala 
    50                  55                  60                  


Glu Glu Lys Thr Lys Val Lys Arg 
65                  70          


<210>  9
<211>  64
<212>  PRT
<213>  human

<400>  9

Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala Lys Asn Gly 
1               5                   10                  15      


Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Arg Gly Pro Asp Gly 
            20                  25                  30          


Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr Phe Gln Ala 
        35                  40                  45              


Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Ala Arg Asn Lys Arg 
    50                  55                  60                  


<210>  10
<211>  64
<212>  PRT
<213>  human

<400>  10

Glu Ile Val Lys Leu Cys Ser Gln Tyr Gln Asn Gln Ala Lys Asn Gly 
1               5                   10                  15      


Ile Leu Phe Cys Thr Arg Glu Asn Asp Pro Ile Cys Gly Pro Asp Gly 
            20                  25                  30          


Lys Met His Gly Asn Leu Cys Ser Met Cys Gln Ala Tyr Phe Gln Ala 
        35                  40                  45              


Glu Asn Glu Glu Lys Lys Lys Ala Glu Ala Arg Cys Arg Asn Lys Arg 
    50                  55                  60                  


<210>  11
<211>  70
<212>  PRT
<213>  human

<400>  11

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Lys Ser Arg Asn Lys Arg 
65                  70  


<210>  12
<211>  70
<212>  PRT
<213>  human

<400>  12

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Cys Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Lys Cys Arg Asn Lys Arg 
65                  70  


<210>  13
<211>  70
<212>  PRT
<213>  human

<400>  13

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Asn Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Lys Ser Arg Asn Lys Arg 
65                  70  


<210>  14
<211>  70
<212>  PRT
<213>  human

<400>  14

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Asn Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Cys Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Lys Cys Arg Asn Lys Arg 
65                  70  


<210>  15
<211>  70
<212>  PRT
<213>  human

<400>  15

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Glu Ser Arg Asn Lys Arg 
65                  70  


<210>  16
<211>  70
<212>  PRT
<213>  human

<400>  16

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Ser Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Cys Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Glu Cys Arg Asn Lys Arg 
65                  70  


<210>  17
<211>  70
<212>  PRT
<213>  human

<400>  17

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Asn Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Glu Ser Arg Asn Lys Arg 
65                  70  


<210>  18
<211>  70
<212>  PRT
<213>  human

<400>  18

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Asn Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Cys Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Glu Cys Arg Asn Lys Arg 
65                  70  


<210>  19
<211>  64
<212>  PRT
<213>  human

<400>  19

Gln Ser Lys Ser Thr Ala Ser Phe Glu Glu Leu Cys Ser Glu Tyr Arg 
1               5                   10                  15      


Lys Ser Arg Lys Asn Gly Arg Leu Phe Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Met His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Ala Phe Phe Gln Gln Glu Glu Arg Ala Arg Ala Lys Ala Lys Arg 
    50                  55                  60                  


<210>  20
<211>  71
<212>  PRT
<213>  human

<400>  20

Glu Ala Ala Lys Glu Ile Cys Ser Glu Phe Arg Asp Gln Val Arg Asn 
1               5                   10                  15      


Gly Thr Leu Ile Cys Thr Arg Glu His Asn Pro Val Arg Gly Pro Asp 
            20                  25                  30          


Gly Lys Met His Gly Asn Lys Cys Ala Met Cys Ala Ser Val Phe Lys 
        35                  40                  45              


Leu Glu Glu Glu Glu Lys Lys Asn Asp Lys Glu Glu Lys Gly Lys Val 
    50                  55                  60                  


Glu Ala Glu Lys Val Lys Arg 
65                  70      


<210>  21
<211>  71
<212>  PRT
<213>  human

<400>  21

Glu Ala Ala Lys Glu Ile Cys Ser Glu Phe Arg Asp Gln Val Arg Asn 
1               5                   10                  15      


Gly Thr Leu Ile Cys Thr Arg Glu His Asn Pro Val Cys Gly Pro Asp 
            20                  25                  30          


Gly Lys Met His Gly Asn Lys Cys Ala Met Cys Ala Ser Val Phe Lys 
        35                  40                  45              


Leu Glu Glu Glu Glu Lys Lys Asn Asp Lys Glu Glu Cys Gly Lys Val 
    50                  55                  60                  


Glu Ala Glu Lys Val Lys Arg 
65                  70      


<210>  22
<211>  65
<212>  PRT
<213>  human

<400>  22

Glu Ala Val Gln Glu Leu Cys Ser Glu Tyr Arg His Tyr Val Arg Asn 
1               5                   10                  15      


Gly Arg Leu Pro Cys Thr Arg Glu Asn Asp Pro Ile Glu Gly Leu Asp 
            20                  25                  30          


Gly Lys Ile His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln 
        35                  40                  45              


Gln Glu Ala Lys Glu Lys Glu Arg Ala Glu Pro Arg Ala Lys Val Lys 
    50                  55                  60                  


Arg 
65  


<210>  23
<211>  65
<212>  PRT
<213>  human

<400>  23

Glu Ala Val Gln Glu Leu Cys Ser Glu Tyr Arg His Tyr Val Arg Asn 
1               5                   10                  15      


Gly Arg Leu Pro Cys Thr Arg Glu Asn Asp Pro Ile Cys Gly Leu Asp 
            20                  25                  30          


Gly Lys Ile His Gly Asn Thr Cys Ser Met Cys Glu Ala Phe Phe Gln 
        35                  40                  45              


Gln Glu Ala Lys Glu Lys Glu Arg Ala Glu Pro Arg Cys Lys Val Lys 
    50                  55                  60                  


Arg 
65  


<210>  24
<211>  64
<212>  PRT
<213>  human

<400>  24

Glu Ala Glu Lys Glu Thr Cys Asp Glu Phe Arg Arg Leu Leu Gln Asn 
1               5                   10                  15      


Gly Lys Leu Phe Cys Thr Arg Glu Asn Asp Pro Val Arg Gly Pro Asp 
            20                  25                  30          


Gly Lys Thr His Gly Asn Lys Cys Ala Met Cys Lys Ala Val Phe Gln 
        35                  40                  45              


Lys Glu Asn Glu Glu Arg Lys Arg Lys Glu Glu Glu Asp Gln Arg Asn 
    50                  55                  60                  


<210>  25
<211>  64
<212>  PRT
<213>  human

<400>  25

Glu Ala Glu Lys Glu Thr Cys Asp Glu Phe Arg Arg Leu Leu Gln Asn 
1               5                   10                  15      


Gly Lys Leu Phe Cys Thr Arg Glu Asn Asp Pro Val Cys Gly Pro Asp 
            20                  25                  30          


Gly Lys Thr His Gly Asn Lys Cys Ala Met Cys Lys Ala Val Phe Gln 
        35                  40                  45              


Lys Glu Asn Glu Glu Arg Lys Arg Lys Glu Glu Glu Cys Gln Arg Asn 
    50                  55                  60                  


<210>  26
<211>  74
<212>  PRT
<213>  human

<400>  26

Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln Asp 
1               5                   10                  15      


Glu Cys Ala Glu Tyr Arg Glu Gln Met Lys Asn Gly Arg Leu Ser Cys 
            20                  25                  30          


Thr Arg Glu Ser Asp Pro Val Arg Asp Ala Asp Gly Lys Ser Tyr Asn 
        35                  40                  45              


Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu Arg 
    50                  55                  60                  


Lys Asn Glu Tyr Ser Arg Ser Arg Ser Asn 
65                  70                  


<210>  27
<211>  74
<212>  PRT
<213>  human

<400>  27

Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln Asp 
1               5                   10                  15      


Glu Cys Ala Glu Tyr Arg Glu Gln Met Lys Asn Gly Arg Leu Ser Cys 
            20                  25                  30          


Thr Arg Glu Ser Asp Pro Val Cys Asp Ala Asp Gly Lys Ser Tyr Asn 
        35                  40                  45              


Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu Arg 
    50                  55                  60                  


Lys Asn Glu Tyr Ser Arg Ser Cys Ser Asn 
65                  70                  


<210>  28
<211>  74
<212>  PRT
<213>  human

<400>  28

Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln Asp 
1               5                   10                  15      


Glu Cys Ala Glu Tyr Gln Glu Gln Met Lys Asn Gly Arg Leu Ser Cys 
            20                  25                  30          


Thr Arg Glu Ser Asp Pro Val Arg Asp Ala Asp Gly Lys Ser Tyr Asn 
        35                  40                  45              


Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu Arg 
    50                  55                  60                  


Lys Asn Glu Tyr Ser Arg Ser Arg Ser Asn 
65                  70                  


<210>  29
<211>  74
<212>  PRT
<213>  human

<400>  29

Ala Ala Gly His Gly Ser Ser Gly Gly Gly Gly Gly Asn Thr Gln Asp 
1               5                   10                  15      


Glu Cys Ala Glu Tyr Gln Glu Gln Met Lys Asn Gly Arg Leu Ser Cys 
            20                  25                  30          


Thr Arg Glu Ser Asp Pro Val Cys Asp Ala Asp Gly Lys Ser Tyr Asn 
        35                  40                  45              


Asn Gln Cys Thr Met Cys Lys Ala Lys Leu Glu Arg Glu Ala Glu Arg 
    50                  55                  60                  


Lys Asn Glu Tyr Ser Arg Ser Cys Ser Asn 
65                  70                  


<210>  30
<211>  68
<212>  PRT
<213>  human

<400>  30

Gly Thr Gly Ser Glu Ser Gly Lys Asp Thr Cys Asp Glu Phe Arg Ser 
1               5                   10                  15      


Gln Met Lys Asn Gly Lys Leu Ile Cys Thr Arg Glu Ser Asp Pro Val 
            20                  25                  30          


Arg Gly Pro Asp Gly Lys Thr His Gly Asn Lys Cys Thr Met Cys Lys 
        35                  40                  45              


Glu Lys Leu Glu Arg Glu Ala Ala Glu Lys Lys Lys Lys Glu Asp Glu 
    50                  55                  60                  


Asp Arg Ser Asn 
65              


<210>  31
<211>  68
<212>  PRT
<213>  human

<400>  31

Gly Thr Gly Ser Glu Ser Gly Lys Asp Thr Cys Asp Glu Phe Arg Ser 
1               5                   10                  15      


Gln Met Lys Asn Gly Lys Leu Ile Cys Thr Arg Glu Ser Asp Pro Val 
            20                  25                  30          


Cys Gly Pro Asp Gly Lys Thr His Gly Asn Lys Cys Thr Met Cys Lys 
        35                  40                  45              


Glu Lys Leu Glu Arg Glu Ala Ala Glu Lys Lys Lys Lys Glu Asp Glu 
    50                  55                  60                  


Cys Arg Ser Asn 
65              


<210>  32
<211>  79
<212>  PRT
<213>  human

<400>  32

Thr Gly Glu Arg Ser Asn Thr Gly Glu Arg Ser Asn Asp Lys Glu Asp 
1               5                   10                  15      


Leu Cys Arg Glu Phe Arg Ser Met Gln Arg Asn Gly Lys Leu Ile Cys 
            20                  25                  30          


Thr Arg Glu Asn Asn Pro Val Arg Gly Pro Tyr Gly Lys Met His Ile 
        35                  40                  45              


Asn Lys Cys Ala Met Cys Gln Ser Ile Phe Asp Arg Glu Ala Asn Glu 
    50                  55                  60                  


Arg Lys Lys Lys Asp Glu Glu Lys Ser Ser Ser Lys Pro Ser Asn 
65                  70                  75                  


<210>  33
<211>  79
<212>  PRT
<213>  human

<400>  33

Thr Gly Glu Arg Ser Asn Thr Gly Glu Arg Ser Asn Asp Lys Glu Asp 
1               5                   10                  15      


Leu Cys Arg Glu Phe Arg Ser Met Gln Arg Asn Gly Lys Leu Ile Cys 
            20                  25                  30          


Thr Arg Glu Asn Asn Pro Val Cys Gly Pro Tyr Gly Lys Met His Ile 
        35                  40                  45              


Asn Lys Cys Ala Met Cys Gln Ser Ile Phe Asp Arg Glu Ala Asn Glu 
    50                  55                  60                  


Arg Lys Lys Lys Asp Glu Glu Cys Ser Ser Ser Lys Pro Ser Asn 
65                  70                  75                  


<210>  34
<211>  67
<212>  PRT
<213>  human

<400>  34

Asn Ala Lys Asp Glu Cys Ser Glu Phe Arg Asn Tyr Ile Arg Asn Asn 
1               5                   10                  15      


Glu Leu Ile Cys Pro Arg Glu Asn Asp Pro Val His Gly Ala Asp Gly 
            20                  25                  30          


Lys Phe Tyr Thr Asn Lys Cys Tyr Met Cys Arg Ala Val Phe Leu Thr 
        35                  40                  45              


Glu Ala Leu Glu Arg Ala Lys Leu Gln Glu Lys Pro Ser His Val Arg 
    50                  55                  60                  


Ala Ser Gln 
65          


<210>  35
<211>  67
<212>  PRT
<213>  human

<400>  35

Asn Ala Lys Asp Glu Cys Ser Glu Phe Arg Asn Tyr Ile Arg Asn Asn 
1               5                   10                  15      


Glu Leu Ile Cys Pro Arg Glu Asn Asp Pro Val Cys Gly Ala Asp Gly 
            20                  25                  30          


Lys Phe Tyr Thr Asn Lys Cys Tyr Met Cys Arg Ala Val Phe Leu Thr 
        35                  40                  45              


Glu Ala Leu Glu Arg Ala Lys Leu Gln Glu Lys Cys Ser His Val Arg 
    50                  55                  60                  


Ala Ser Gln 
65          


<210>  36
<211>  87
<212>  PRT
<213>  human

<400>  36

Glu Glu Asp Ser Pro Asp Ser Phe Ser Ser Leu Asp Ser Glu Met Cys 
1               5                   10                  15      


Lys Asp Tyr Arg Val Leu Pro Arg Ile Gly Tyr Leu Cys Pro Lys Asp 
            20                  25                  30          


Leu Lys Pro Val Cys Gly Asp Asp Gly Gln Thr Tyr Asn Asn Pro Cys 
        35                  40                  45              


Met Leu Cys His Glu Asn Leu Ile Arg Gln Thr Asn Thr His Ile Arg 
    50                  55                  60                  


Ser Thr Gly Lys Cys Glu Glu Ser Ser Thr Pro Gly Thr Thr Ala Ala 
65                  70                  75                  80  


Ser Met Pro Pro Ser Asp Glu 
                85          


<210>  37
<211>  80
<212>  PRT
<213>  human

<400>  37

Met Lys Leu Ser Gly Met Phe Leu Leu Leu Ser Leu Ala Leu Phe Cys 
1               5                   10                  15      


Phe Leu Thr Gly Val Phe Ser Gln Gly Gly Gln Val Asp Cys Gly Glu 
            20                  25                  30          


Phe Gln Asp Pro Lys Val Tyr Cys Thr Arg Glu Ser Asn Pro His Cys 
        35                  40                  45              


Gly Ser Asp Gly Gln Thr Tyr Gly Asn Lys Cys Ala Phe Cys Lys Ala 
    50                  55                  60                  


Ile Val Lys Ser Gly Gly Lys Ile Ser Leu Lys His Pro Gly Lys Cys 
65                  70                  75                  80  


<210>  38
<211>  23
<212>  PRT
<213>  human

<400>  38

Met Lys Leu Ser Gly Met Phe Leu Leu Leu Ser Leu Ala Leu Phe Cys 
1               5                   10                  15      


Phe Leu Thr Gly Val Phe Ser 
            20              


<210>  39
<211>  57
<212>  PRT
<213>  human

<400>  39

Gln Gly Gly Gln Val Asp Cys Gly Glu Phe Gln Asp Pro Lys Val Tyr 
1               5                   10                  15      


Cys Thr Arg Glu Ser Asn Pro His Cys Gly Ser Asp Gly Gln Thr Tyr 
            20                  25                  30          


Gly Asn Lys Cys Ala Phe Cys Lys Ala Ile Val Lys Ser Gly Gly Lys 
        35                  40                  45              


Ile Ser Leu Lys His Pro Gly Lys Cys 
    50                  55          


<210>  40
<211>  86
<212>  PRT
<213>  human

<400>  40

Met Arg Ala Thr Ala Ile Val Leu Leu Leu Ala Leu Thr Leu Ala Thr 
1               5                   10                  15      


Met Phe Ser Ile Glu Cys Ala Lys Gln Thr Lys Gln Met Val Asp Cys 
            20                  25                  30          


Ser His Tyr Lys Lys Leu Pro Pro Gly Gln Gln Arg Phe Cys His His 
        35                  40                  45              


Met Tyr Asp Pro Ile Cys Gly Ser Asp Gly Lys Thr Tyr Lys Asn Asp 
    50                  55                  60                  


Cys Phe Phe Cys Ser Lys Val Lys Lys Thr Asp Gly Thr Leu Lys Phe 
65                  70                  75                  80  


Val His Phe Gly Lys Cys 
                85      


<210>  41
<211>  19
<212>  PRT
<213>  human

<400>  41

Met Arg Ala Thr Ala Ile Val Leu Leu Leu Ala Leu Thr Leu Ala Thr 
1               5                   10                  15      


Met Phe Ser 
            


<210>  42
<211>  67
<212>  PRT
<213>  human

<400>  42

Ile Glu Cys Ala Lys Gln Thr Lys Gln Met Val Asp Cys Ser His Tyr 
1               5                   10                  15      


Lys Lys Leu Pro Pro Gly Gln Gln Arg Phe Cys His His Met Tyr Asp 
            20                  25                  30          


Pro Ile Cys Gly Ser Asp Gly Lys Thr Tyr Lys Asn Asp Cys Phe Phe 
        35                  40                  45              


Cys Ser Lys Val Lys Lys Thr Asp Gly Thr Leu Lys Phe Val His Phe 
    50                  55                  60                  


Gly Lys Cys 
65          


<210>  43
<211>  55
<212>  PRT
<213>  human

<400>  43

Lys Asn Glu Asp Gln Glu Met Cys His Glu Phe Gln Ala Phe Met Lys 
1               5                   10                  15      


Asn Gly Lys Leu Phe Cys Pro Gln Asp Lys Lys Phe Phe Gln Ser Leu 
            20                  25                  30          


Asp Gly Ile Met Phe Ile Asn Lys Cys Ala Thr Cys Lys Met Ile Leu 
        35                  40                  45              


Glu Lys Glu Ala Lys Ser Gln 
    50                  55  


<210>  44
<211>  68
<212>  PRT
<213>  human

<400>  44

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Asn Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Glu Ser Arg Asn 
65              


<210>  45
<211>  32
<212>  PRT
<213>  human

<400>  45

Cys Pro Asp Tyr Tyr Glu Ala Val Cys Gly Thr Asp Gly Lys Thr Tyr 
1               5                   10                  15      


Asp Asn Arg Cys Ala Leu Cys Ala Glu Asn Ala Lys Thr Gly Ser Gln 
            20                  25                  30          


<210>  46
<211>  32
<212>  PRT
<213>  human

<400>  46

Cys Pro Arg Asp Tyr Asp Pro Val Cys Gly Thr Asp Gly Lys Thr Tyr 
1               5                   10                  15      


Ala Asn Glu Cys Ile Leu Cys Phe Glu Asn Arg Lys Phe Gly Thr Ser 
            20                  25                  30          


<210>  47
<211>  34
<212>  PRT
<213>  human

<400>  47

Cys Pro Lys Asp Leu Lys Pro Val Cys Gly Asp Asp Gly Gln Thr Tyr 
1               5                   10                  15      


Asn Asn Pro Cys Met Leu Cys His Glu Asn Leu Ile Arg Gln Thr Asn 
            20                  25                  30          


Thr His 
        


<210>  48
<211>  35
<212>  PRT
<213>  human

<400>  48

Cys Pro Lys Ile Leu Lys Pro Val Cys Gly Ser Asp Gly Arg Thr Tyr 
1               5                   10                  15      


Ala Asn Ser Cys Ile Ala Arg Cys Asn Gly Val Ser Ile Lys Ser Glu 
            20                  25                  30          


Gly Ser Cys 
        35  



<210>  49
<211>  68
<212>  PRT
<213>  human

<400>  8

Glu Ser Gly Lys Ala Thr Ser Tyr Ala Glu Leu Cys Asn Glu Tyr Arg 
1               5                   10                  15      


Lys Leu Val Arg Asn Gly Lys Leu Ala Cys Thr Arg Glu Asn Asp Pro 
            20                  25                  30          


Ile Gln Gly Pro Asp Gly Lys Val His Gly Asn Thr Cys Ser Met Cys 
        35                  40                  45              


Glu Val Phe Phe Gln Ala Glu Glu Glu Glu Lys Lys Lys Lys Glu Gly 
    50                  55                  60                  


Glu Ser Arg Asn 
65              


