               SEQUENCE LISTING

<110> Jacobs University Bremen gGmbH

<120> SYNTHETISCHES MHC-KLASSE-II-PROTEIN

<130> P01693WO

<150> DE102020109 447.7
<151> 2020-04-03

<160> 6

<170> BiSSAP 1.3.6

<210> 1
<211> 229
<212> PRT
<213> Homo sapiens


<220> 
<223> HLA-DRA*01:01

<400> 1
Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      
Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          
His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              
Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  
Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  
Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      
Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         
Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             
Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 
Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 
Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     
His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Asn 
            180                 185                 190         
Val Val Cys Ala Leu Gly Leu Thr Val Gly Leu Val Gly Ile Ile Ile 
        195                 200                 205             
Gly Thr Ile Phe Ile Ile Lys Gly Val Arg Lys Ser Asn Ala Ala Glu 
    210                 215                 220                 
Arg Arg Gly Pro Leu 
225                 

<210> 2
<211> 237
<212> PRT
<213> Homo sapiens


<220> 
<223> HLA-DRB1*01:01

<400> 2
Gly Asp Thr Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His 
1               5                   10                  15      
Phe Phe Asn Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr 
            20                  25                  30          
Asn Gln Glu Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              
Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  
Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  
His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu 
                85                  90                  95      
Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         
Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             
Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser 
    130                 135                 140                 
Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 
Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     
His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         
Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
        195                 200                 205             
Gly Leu Leu Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln 
    210                 215                 220                 
Lys Gly His Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
225                 230                 235         

<210> 3
<211> 229
<212> PRT
<213> Homo sapiens


<220> 
<223> HLA-DQA1*03:01

<400> 3
Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr 
1               5                   10                  15      
Gly Pro Ser Gly Gln Tyr Ser His Glu Phe Asp Gly Asp Glu Glu Phe 
            20                  25                  30          
Tyr Val Asp Leu Glu Arg Lys Glu Thr Val Trp Gln Leu Pro Leu Phe 
        35                  40                  45              
Arg Arg Phe Arg Arg Phe Asp Pro Gln Phe Ala Leu Thr Asn Ile Ala 
    50                  55                  60                  
Val Leu Lys His Asn Leu Asn Ile Val Ile Lys Arg Ser Asn Ser Thr 
65                  70                  75                  80  
Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser Lys Ser Pro 
                85                  90                  95      
Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val Asp Asn Ile 
            100                 105                 110         
Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly His Ser Val 
        115                 120                 125             
Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp His Ser 
    130                 135                 140                 
Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Asp Asp Glu Ile 
145                 150                 155                 160 
Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     
His Trp Glu Pro Glu Ile Pro Thr Pro Met Ser Glu Leu Thr Glu Thr 
            180                 185                 190         
Val Val Cys Ala Leu Gly Leu Ser Val Gly Leu Val Gly Ile Val Val 
        195                 200                 205             
Gly Thr Val Leu Ile Ile Arg Gly Leu Arg Ser Val Gly Ala Ser Arg 
    210                 215                 220                 
His Gln Gly Pro Leu 
225                 

<210> 4
<211> 229
<212> PRT
<213> Homo sapiens


<220> 
<223> HLA-DQB1*02:01

<400> 4
Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
1               5                   10                  15      
Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
            20                  25                  30          
Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
        35                  40                  45              
Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  
Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
65                  70                  75                  80  
His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
                85                  90                  95      
Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
            100                 105                 110         
Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
        115                 120                 125             
Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
    130                 135                 140                 
Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
145                 150                 155                 160 
Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
                165                 170                 175     
His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
            180                 185                 190         
Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
        195                 200                 205             
Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
    210                 215                 220                 
Lys Gly Leu Leu His 
225                 

<210> 5
<211> 229
<212> PRT
<213> Homo sapiens


<220> 
<223> HLA-DPA1*01:03

<400> 5
Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His 
1               5                   10                  15      
Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe 
            20                  25                  30          
Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe 
        35                  40                  45              
Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala 
    50                  55                  60                  
Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr 
65                  70                  75                  80  
Gln Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro 
                85                  90                  95      
Val Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe 
            100                 105                 110         
Phe Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val 
        115                 120                 125             
Thr Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser 
    130                 135                 140                 
Phe His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe 
145                 150                 155                 160 
Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys 
                165                 170                 175     
His Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr 
            180                 185                 190         
Val Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val 
        195                 200                 205             
Gly Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg 
    210                 215                 220                 
Ala Gln Gly Thr Leu 
225                 

<210> 6
<211> 229
<212> PRT
<213> Homo sapiens


<220> 
<223> HLA-DPB1*04:01

<400> 6
Arg Ala Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr 
1               5                   10                  15      
Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg 
            20                  25                  30          
Glu Glu Phe Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val 
        35                  40                  45              
Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp 
    50                  55                  60                  
Ile Leu Glu Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn 
65                  70                  75                  80  
Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg 
                85                  90                  95      
Val Asn Val Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu 
            100                 105                 110         
Leu Val Cys His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg 
        115                 120                 125             
Trp Phe Leu Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn 
    130                 135                 140                 
Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu 
145                 150                 155                 160 
Met Thr Pro Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr 
                165                 170                 175     
Ser Leu Asp Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser 
            180                 185                 190         
Ala Arg Ser Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu 
        195                 200                 205             
Ile Ile Cys Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val 
    210                 215                 220                 
Gln Arg Gly Ser Ala 
225                 

