                         SEQUENCE LISTING

<110>  Ͼѱ¹ҽƼ޹˾
 
<120>  ȫԴCD22ǶϿԭ弰Ӧ

<130>  P10726-PCT

<150>  CN202010254388.3
<151>  2020-04-02

<160>  45    

<170>  PatentIn version 3.3

<210>  1
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  ¡17 LCDR1

<400>  1

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  ¡17 LCDR2

<400>  2

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡17 LCDR3

<400>  3

Gln Gln Tyr Glu Arg Phe Pro Trp Thr 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡17 HCDR1 

<400>  4

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  ¡17 HCDR2 

<400>  5

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  ¡17 HCDR3 

<400>  6

Ala Lys Val Gly Ile Ser Ser Leu His Gly Met Asp Val 
1               5                   10              


<210>  7
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 LCDR1

<400>  7

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 LCDR2

<400>  8

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 LCDR3

<400>  9

Gln Gln Ala Asn Thr Tyr Ser Pro Thr 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 HCDR1

<400>  10

Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
1               5                   


<210>  11
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 HCDR2

<400>  11

Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 HCDR3

<400>  12

Ala Arg Asp Leu Tyr Arg Asp Gly Met Asp Val 
1               5                   10      


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 LCDR1

<400>  13

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  14
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 LCDR2

<400>  14

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 LCDR3

<400>  15

Gln Gln Ala Gly Leu Phe Pro Tyr Thr 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 HCDR1

<400>  16

Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser 
1               5                   10  


<210>  17
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 HCDR2

<400>  17

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 HCDR3

<400>  18

Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp Ile 
1               5                   10          


<210>  19
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 17 VL

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Arg Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 17 VH

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Ile Ser Ser Leu His Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 VL

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Thr Tyr Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 VH

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Tyr Arg Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 VL

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  24
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 VH

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 17 scFv

<400>  25

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Ile Ser Ser Leu His Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Glu Arg Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  26
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 scFv

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Tyr Arg Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Ser Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
    210                 215                 220                 


Thr Tyr Ser Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  27
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 scFv

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  28
<211>  246
<212>  PRT
<213>  Artificial

<220>
<223>  M971 scFv

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  29
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  T2A

<400>  29

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  30
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  CD8źİ

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  31
<211>  83
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 ͿĤ

<400>  31

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn 
            


<210>  32
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BB ̼ź 

<400>  32

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  33
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD3z ź 

<400>  33

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  34
<211>  357
<212>  PRT
<213>  Artificial

<220>
<223>  tEGFR 

<400>  34

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  35
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 17 CAR 

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Val Gly Ile Ser Ser Leu His Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser 
        195                 200                 205             


Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Tyr Glu Arg Phe Pro Trp Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Phe Val Pro Val Phe Leu Pro Ala Lys 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            500                 505                 510         


Gly Asp Val Glu Glu Asn Pro Gly 
        515                 520 


<210>  36
<211>  517
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 28 CAR 

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Leu Tyr Arg Asp Gly Met Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Asp Ala Ser Ser Leu Glu 
        195                 200                 205             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Ala Asn Thr Tyr Ser Pro Thr Phe Gly Gly Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly 
        515         


<210>  37
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  ¡ 80 CAR 

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Pro Gly Tyr Glu Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                165                 170                 175     


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        195                 200                 205             


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gln Gln Ala Gly Leu Phe Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Phe Val Pro Val Phe Leu Pro Ala Lys 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
            500                 505                 510         


Gly Asp Val Glu Glu Asn Pro Gly 
        515                 520 


<210>  38
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  ¡ 17 scFv 

<400>  38
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc caaggtagga    300

atatccagct tacacggaat ggacgtatgg ggccagggaa caactgtcac cgtcagctca    360

ggtggcgggg gcagcggcgg aggcggatcc ggaggcggag ggagtgacat ccagatgacc    420

cagtctcctt ccaccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggcc    480

agtcagagta ttagtagctg gttggcctgg tatcagcaga aaccagggaa agcccctaag    540

ctcctgatct ataaagcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt    600

ggatctggga cagaattcac tctcaccatc agcagcctgc agcctgatga ttttgcaact    660

tattactgcc agcagtacga acgcttccct tggacttttg gcggagggac caaggttgag    720

atcaaa                                                               726


<210>  39
<211>  717
<212>  DNA
<213>  Artificial

<220>
<223>  ¡ 28 scFv 

<400>  39
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc    120

gccgggaagg gactggagtg gattgggcgt atctatacca gtgggagcac caactacaac    180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gcggtgtact actgcgccag agacttgtac    300

agagatggaa tggacgtatg gggccaggga acaactgtca ccgtcagctc aggtggcggg    360

ggcagcggcg gaggcggatc cggaggcgga gggagtgaca tccagatgac ccagtctcct    420

tccaccctgt ctgcatctgt aggagacaga gtcaccatca cttgccgggc cagtcagagt    480

attagtagct ggttggcctg gtatcagcag aaaccaggga aagcccctaa gctcctgatc    540

tccgatgcct ccagtttgga aagtggggtc ccatcaaggt tcagcggcag tggatctggg    600

acagaattca ctctcaccat cagcagcctg cagcctgatg attttgcaac ttattactgc    660

cagcaggcca atacctactc tcctactttt ggcggaggga ccaaggttga gatcaaa       717


<210>  40
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  ¡ 80 scFv 

<400>  40
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc     60

acctgcgctg tctctggtgg ctccatcagc agtagtaact ggtggagttg ggtccgccag    120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccaactac    180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc    240

ctgaagctga gctctgtgac cgccgcggac acggcggtgt actactgcgc cagacttcct    300

ggatacgagt cagctttcga catatggggt cagggtacaa tggtcaccgt cagctcaggt    360

ggcgggggca gcggcggagg cggatccgga ggcggaggga gtgaaattgt gttgacgcag    420

tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt    480

cagagtgtta gcagcagcta cttagcctgg taccagcaga aacctggcca ggctcccagg    540

ctcctcatct atggtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt    600

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgaaga ttttgcagtg    660

tattactgtc agcaggccgg actcttccct tacacttttg gcggagggac caaggttgag    720

atcaaa                                                               726


<210>  41
<211>  738
<212>  DNA
<213>  Artificial

<220>
<223>  M971 scFv

<400>  41
caggtgcagc tccagcagag cggccccggc ctggtaaagc ccagccaaac cctctccctg     60

acctgcgcta tcagcggcga ttccgtgagc agcaacagcg ccgcctggaa ttggatccgt    120

cagagcccca gcaggggcct ggagtggctg gggcggacct attaccggag taagtggtac    180

aacgactacg ccgtaagcgt gaagagccgc atcaccatta atcctgacac cagcaagaac    240

cagttcagtc tgcagctgaa cagcgtgact cccgaggaca ccgccgtgta ctactgcgcc    300

cgcgaggtga ctggagacct ggaagacgcc ttcgacatct ggggccaggg cacaatggtg    360

accgtcagca gcggtggcgg gggcagcggc ggaggcggat ccggaggcgg agggagtgac    420

atacagatga cccagagccc tagcagcctc tctgccagcg tgggagaccg ggtgaccatc    480

acctgccgcg ccagtcagac catctggtct tatctgaact ggtaccagca acggcccggc    540

aaggccccta acctgttgat ctacgccgcc agcagtctcc agagcggcgt tccatctcgc    600

ttcagcggcc gcggcagcgg cacagacttc accctgacca tcagcagcct gcaggccgag    660

gacttcgcca cctactactg ccagcagagc tacagcatcc cccagacttt cggacagggc    720

accaagttgg agatcaaa                                                  738


<210>  42
<211>  2276
<212>  DNA
<213>  Artificial

<220>
<223>  PXL0662CARֺ

<400>  42
gccgccacca tggccctgcc tgtgacagct ctgctcctcc ctctggccct gctgctccat     60

gccgccagac ccgagacgtg agaattaata cgactcacta tagagggact ggtgaaatgc    120

agttcaaggt ttacacctat aaaagagaga gccgctatcg cctgtttgtg gatgtacaga    180

gtgatattat tgacacgccc gggcgacgga tggtgatccc cctggccagt gcacgtctgc    240

tgtcagataa agtctcccgt gaactttacc cggtggtgca tatcggggat gaaagctggc    300

gcatgatgac cacccagatg gtcagtgtgc cggtctccgt catcggagaa gaagtggctg    360

atctcagcca ccgcgaaaat gacatcaaaa acgccattaa tctgatgttc tggggaatat    420

aacgtctctt cgtgcccgtg ttcctgcccg ccaaacctac caccacccct gcccctagac    480

ctcccacccc agccccaaca atcgccagcc agcctctgtc tctgcggccc gaagcctgta    540

gacctgctgc cggcggagcc gtgcacacca gaggcctgga cttcgcctgc gacatctaca    600

tctgggcccc tctggccggc acctgtggcg tgctgctgct gagcctggtg atcaccctgt    660

actgcaacca ccggaacaaa cggggcagaa agaaactcct gtatatattc aaacaaccat    720

ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga tttccagaag    780

aagaagaagg aggatgtgaa ctgagagtga agttcagcag atccgccgac gcccctgcct    840

accagcaggg acagaaccag ctgtacaacg agctgaacct gggcagacgg gaagagtacg    900

acgtgctgga caagcggaga ggccgggacc ccgagatggg cggaaagccc agacggaaga    960

acccccagga aggcctgtat aacgaactgc agaaagacaa gatggccgag gcctacagcg   1020

agatcggcat gaagggcgag cggaggcgcg gcaagggcca cgatggcctg taccagggcc   1080

tgagcaccgc caccaaggac acctacgacg ccctgcacat gcaggccctg ccccccagag   1140

gatccggaga gggaaggggc agcttattaa catgtggcga tgtggaagag aaccccggtc   1200

ccatgctgct gctcgtgacc tctttactgt tatgtgagct gccccacccc gcttttttac   1260

tgatccctcg taaggtgtgt aacggaatcg gcattggcga gttcaaggac tctttaagca   1320

tcaacgccac aaacatcaag cacttcaaga attgtacctc catcagcggc gatttacaca   1380

ttctccccgt ggcttttcgt ggcgattcct tcacccacac cccccctctg gacccccaag   1440

agctggacat tttaaaaacc gtgaaggaga tcaccggctt tctgctgatc caagcttggc   1500

ccgagaatcg taccgacctc cacgccttcg agaatttaga gattattcgt ggaaggacca   1560

agcagcacgg ccagttctct ttagccgtcg tgtctttaaa cattaccagc ctcggtttaa   1620

ggtctttaaa ggagattagc gacggcgacg tgatcatctc cggcaacaag aacctctgct   1680

acgccaacac catcaactgg aagaagctgt tcggaaccag cggccaaaag accaagatca   1740

tcagcaatcg tggagagaac tcttgtaagg ccactggtca agtttgccac gccctctgta   1800

gccccgaagg atgttggggc cccgagccta gggactgtgt tagctgcaga aacgtgagca   1860

gaggcagaga gtgtgtggac aaatgcaatt tactggaagg agagcctagg gagttcgtgg   1920

agaacagcga atgtatccag tgccaccccg agtgtttacc tcaagccatg aacatcactt   1980

gtaccggaag gggccccgat aactgcatcc aatgcgccca ctacatcgac ggaccccact   2040

gcgtgaaaac ttgtcccgcc ggagtgatgg gagagaataa cactttagtg tggaagtacg   2100

ccgacgctgg ccacgtctgc catctgtgcc accccaactg tacctacggc tgcactggtc   2160

ccggtttaga gggatgtcct accaacggcc ccaagatccc ctccatcgcc accggaatgg   2220

tgggcgctct gttattactg ctggtggtgg ctctgggcat cggtttattc atgtga       2276


<210>  43
<211>  2637
<212>  DNA
<213>  Artificial

<220>
<223>  ¡ 17 CAR

<400>  43
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

cccgaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga    120

ctctcctgtg cagcctctgg attcaccttt agcagctatg ccatgagctg ggtccgccag    180

gctccaggga aggggctgga gtgggtctca gctattagtg gtagtggtgg tagcacatac    240

tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg    300

tatctgcaaa tgaacagcct gagagccgag gacacggcgg tgtactactg cgccaaggta    360

ggaatatcca gcttacacgg aatggacgta tggggccagg gaacaactgt caccgtcagc    420

tcaggtggcg ggggcagcgg cggaggcgga tccggaggcg gagggagtga catccagatg    480

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg    540

gccagtcaga gtattagtag ctggttggcc tggtatcagc agaaaccagg gaaagcccct    600

aagctcctga tctataaagc ctccagtttg gaaagtgggg tcccatcaag gttcagcggc    660

agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca    720

acttattact gccagcagta cgaacgcttc ccttggactt ttggcggagg gaccaaggtt    780

gagatcaaat tcgtgcccgt gttcctgccc gccaaaccta ctactacccc tgcacctagg    840

cctcccaccc cagccccaac aatcgccagc cagcctctgt ctctgcggcc cgaagcctgt    900

agacctgctg ccggcggagc cgtgcacacc agaggcctgg acttcgcctg cgacatctac    960

atctgggccc ctctggccgg cacctgtggc gtgctgctgc tgagcctggt gatcaccctg   1020

tactgcaacc accggaacaa acggggcaga aagaaactcc tgtatatatt caaacaacca   1080

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa   1140

gaagaagaag gaggatgtga actgagagtg aagttcagca gatccgccga cgcccctgcc   1200

taccagcagg gacagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac   1260

gacgtgctgg acaagcggag aggccgggac cccgagatgg gcggaaagcc cagacggaag   1320

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc   1380

gagatcggca tgaagggcga gcggaggcgc ggcaagggcc acgatggcct gtaccagggc   1440

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gccccccaga   1500

ggatccggag agggaagggg cagcttatta acatgtggcg atgtggaaga gaaccccggt   1560

cccatgctgc tgctcgtgac ctctttactg ttatgtgagc tgccccaccc cgctttttta   1620

ctgatccctc gtaaggtgtg taacggaatc ggcattggcg agttcaagga ctctttaagc   1680

atcaacgcca caaacatcaa gcacttcaag aattgtacct ccatcagcgg cgatttacac   1740

attctccccg tggcttttcg tggcgattcc ttcacccaca ccccccctct ggacccccaa   1800

gagctggaca ttttaaaaac cgtgaaggag atcaccggct ttctgctgat ccaagcttgg   1860

cccgagaatc gtaccgacct ccacgccttc gagaatttag agattattcg tggaaggacc   1920

aagcagcacg gccagttctc tttagccgtc gtgtctttaa acattaccag cctcggttta   1980

aggtctttaa aggagattag cgacggcgac gtgatcatct ccggcaacaa gaacctctgc   2040

tacgccaaca ccatcaactg gaagaagctg ttcggaacca gcggccaaaa gaccaagatc   2100

atcagcaatc gtggagagaa ctcttgtaag gccactggtc aagtttgcca cgccctctgt   2160

agccccgaag gatgttgggg ccccgagcct agggactgtg ttagctgcag aaacgtgagc   2220

agaggcagag agtgtgtgga caaatgcaat ttactggaag gagagcctag ggagttcgtg   2280

gagaacagcg aatgtatcca gtgccacccc gagtgtttac ctcaagccat gaacatcact   2340

tgtaccggaa ggggccccga taactgcatc caatgcgccc actacatcga cggaccccac   2400

tgcgtgaaaa cttgtcccgc cggagtgatg ggagagaata acactttagt gtggaagtac   2460

gccgacgctg gccacgtctg ccatctgtgc caccccaact gtacctacgg ctgcactggt   2520

cccggtttag agggatgtcc taccaacggc cccaagatcc cctccatcgc caccggaatg   2580

gtgggcgctc tgttattact gctggtggtg gctctgggca tcggtttatt catgtga      2637


<210>  44
<211>  2628
<212>  DNA
<213>  Artificial

<220>
<223>  ¡ 28 CAR

<400>  44
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

ccccaggtgc agctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc    120

ctcacctgca ctgtctctgg tggctccatc agtagttact actggagctg gatccggcag    180

cccgccggga agggactgga gtggattggg cgtatctata ccagtgggag caccaactac    240

aacccctccc tcaagagtcg agtcaccatg tcagtagaca cgtccaagaa ccagttctcc    300

ctgaagctga gctctgtgac cgccgcggac acggcggtgt actactgcgc cagagacttg    360

tacagagatg gaatggacgt atggggccag ggaacaactg tcaccgtcag ctcaggtggc    420

gggggcagcg gcggaggcgg atccggaggc ggagggagtg acatccagat gacccagtct    480

ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgccg ggccagtcag    540

agtattagta gctggttggc ctggtatcag cagaaaccag ggaaagcccc taagctcctg    600

atctccgatg cctccagttt ggaaagtggg gtcccatcaa ggttcagcgg cagtggatct    660

gggacagaat tcactctcac catcagcagc ctgcagcctg atgattttgc aacttattac    720

tgccagcagg ccaataccta ctctcctact tttggcggag ggaccaaggt tgagatcaaa    780

ttcgtgcccg tgttcctgcc cgccaaaccc actactacac cagcacccag acctcccacc    840

ccagccccaa caatcgccag ccagcctctg tctctgcggc ccgaagcctg tagacctgct    900

gccggcggag ccgtgcacac cagaggcctg gacttcgcct gcgacatcta catctgggcc    960

cctctggccg gcacctgtgg cgtgctgctg ctgagcctgg tgatcaccct gtactgcaac   1020

caccggaaca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga   1080

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa   1140

ggaggatgtg aactgagagt gaagttcagc agatccgccg acgcccctgc ctaccagcag   1200

ggacagaacc agctgtacaa cgagctgaac ctgggcagac gggaagagta cgacgtgctg   1260

gacaagcgga gaggccggga ccccgagatg ggcggaaagc ccagacggaa gaacccccag   1320

gaaggcctgt ataacgaact gcagaaagac aagatggccg aggcctacag cgagatcggc   1380

atgaagggcg agcggaggcg cggcaagggc cacgatggcc tgtaccaggg cctgagcacc   1440

gccaccaagg acacctacga cgccctgcac atgcaggccc tgccccccag aggatccgga   1500

gagggaaggg gcagcttatt aacatgtggc gatgtggaag agaaccccgg tcccatgctg   1560

ctgctcgtga cctctttact gttatgtgag ctgccccacc ccgctttttt actgatccct   1620

cgtaaggtgt gtaacggaat cggcattggc gagttcaagg actctttaag catcaacgcc   1680

acaaacatca agcacttcaa gaattgtacc tccatcagcg gcgatttaca cattctcccc   1740

gtggcttttc gtggcgattc cttcacccac accccccctc tggaccccca agagctggac   1800

attttaaaaa ccgtgaagga gatcaccggc tttctgctga tccaagcttg gcccgagaat   1860

cgtaccgacc tccacgcctt cgagaattta gagattattc gtggaaggac caagcagcac   1920

ggccagttct ctttagccgt cgtgtcttta aacattacca gcctcggttt aaggtcttta   1980

aaggagatta gcgacggcga cgtgatcatc tccggcaaca agaacctctg ctacgccaac   2040

accatcaact ggaagaagct gttcggaacc agcggccaaa agaccaagat catcagcaat   2100

cgtggagaga actcttgtaa ggccactggt caagtttgcc acgccctctg tagccccgaa   2160

ggatgttggg gccccgagcc tagggactgt gttagctgca gaaacgtgag cagaggcaga   2220

gagtgtgtgg acaaatgcaa tttactggaa ggagagccta gggagttcgt ggagaacagc   2280

gaatgtatcc agtgccaccc cgagtgttta cctcaagcca tgaacatcac ttgtaccgga   2340

aggggccccg ataactgcat ccaatgcgcc cactacatcg acggacccca ctgcgtgaaa   2400

acttgtcccg ccggagtgat gggagagaat aacactttag tgtggaagta cgccgacgct   2460

ggccacgtct gccatctgtg ccaccccaac tgtacctacg gctgcactgg tcccggttta   2520

gagggatgtc ctaccaacgg ccccaagatc ccctccatcg ccaccggaat ggtgggcgct   2580

ctgttattac tgctggtggt ggctctgggc atcggtttat tcatgtga                2628


<210>  45
<211>  2637
<212>  DNA
<213>  Artificial

<220>
<223>  ¡ 80 CAR

<400>  45
atggccctgc ctgtgacagc tctgctcctc cctctggccc tgctgctcca tgccgccaga     60

ccccaggtgc agctgcagga gtcgggccca ggactggtga agccttcggg gaccctgtcc    120

ctcacctgcg ctgtctctgg tggctccatc agcagtagta actggtggag ttgggtccgc    180

cagcccccag ggaaggggct ggagtggatt ggggaaatct atcatagtgg gagcaccaac    240

tacaacccgt ccctcaagag tcgagtcacc atatcagtag acaagtccaa gaaccagttc    300

tccctgaagc tgagctctgt gaccgccgcg gacacggcgg tgtactactg cgccagactt    360

cctggatacg agtcagcttt cgacatatgg ggtcagggta caatggtcac cgtcagctca    420

ggtggcgggg gcagcggcgg aggcggatcc ggaggcggag ggagtgaaat tgtgttgacg    480

cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc    540

agtcagagtg ttagcagcag ctacttagcc tggtaccagc agaaacctgg ccaggctccc    600

aggctcctca tctatggtgc atccagcagg gccactggca tcccagacag gttcagtggc    660

agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca    720

gtgtattact gtcagcaggc cggactcttc ccttacactt ttggcggagg gaccaaggtt    780

gagatcaaat tcgtgcccgt gttcctgccc gccaaaccaa ctactactcc tgccccaagg    840

ccacccaccc cagccccaac aatcgccagc cagcctctgt ctctgcggcc cgaagcctgt    900

agacctgctg ccggcggagc cgtgcacacc agaggcctgg acttcgcctg cgacatctac    960

atctgggccc ctctggccgg cacctgtggc gtgctgctgc tgagcctggt gatcaccctg   1020

tactgcaacc accggaacaa acggggcaga aagaaactcc tgtatatatt caaacaacca   1080

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa   1140

gaagaagaag gaggatgtga actgagagtg aagttcagca gatccgccga cgcccctgcc   1200

taccagcagg gacagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac   1260

gacgtgctgg acaagcggag aggccgggac cccgagatgg gcggaaagcc cagacggaag   1320

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc   1380

gagatcggca tgaagggcga gcggaggcgc ggcaagggcc acgatggcct gtaccagggc   1440

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gccccccaga   1500

ggatccggag agggaagggg cagcttatta acatgtggcg atgtggaaga gaaccccggt   1560

cccatgctgc tgctcgtgac ctctttactg ttatgtgagc tgccccaccc cgctttttta   1620

ctgatccctc gtaaggtgtg taacggaatc ggcattggcg agttcaagga ctctttaagc   1680

atcaacgcca caaacatcaa gcacttcaag aattgtacct ccatcagcgg cgatttacac   1740

attctccccg tggcttttcg tggcgattcc ttcacccaca ccccccctct ggacccccaa   1800

gagctggaca ttttaaaaac cgtgaaggag atcaccggct ttctgctgat ccaagcttgg   1860

cccgagaatc gtaccgacct ccacgccttc gagaatttag agattattcg tggaaggacc   1920

aagcagcacg gccagttctc tttagccgtc gtgtctttaa acattaccag cctcggttta   1980

aggtctttaa aggagattag cgacggcgac gtgatcatct ccggcaacaa gaacctctgc   2040

tacgccaaca ccatcaactg gaagaagctg ttcggaacca gcggccaaaa gaccaagatc   2100

atcagcaatc gtggagagaa ctcttgtaag gccactggtc aagtttgcca cgccctctgt   2160

agccccgaag gatgttgggg ccccgagcct agggactgtg ttagctgcag aaacgtgagc   2220

agaggcagag agtgtgtgga caaatgcaat ttactggaag gagagcctag ggagttcgtg   2280

gagaacagcg aatgtatcca gtgccacccc gagtgtttac ctcaagccat gaacatcact   2340

tgtaccggaa ggggccccga taactgcatc caatgcgccc actacatcga cggaccccac   2400

tgcgtgaaaa cttgtcccgc cggagtgatg ggagagaata acactttagt gtggaagtac   2460

gccgacgctg gccacgtctg ccatctgtgc caccccaact gtacctacgg ctgcactggt   2520

cccggtttag agggatgtcc taccaacggc cccaagatcc cctccatcgc caccggaatg   2580

gtgggcgctc tgttattact gctggtggtg gctctgggca tcggtttatt catgtga      2637


