
                                SEQUENCE LISTING

<110> Nanjing Legend Biotech Co., Ltd.

<120> COMPOSITIONS AND METHODS FOR REDUCING GRAFT REJECTION IN
      ALLOGENEIC CELL THERAPY 

<130> 76142-20023.41

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> PCT/CN2020/082759
<151> 2020-04-01

<160> 27

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 290
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser
65                  70                  75                  80  
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn
                85                  90                  95      
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr
            100                 105                 110         
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val
        115                 120                 125             
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val
    130                 135                 140                 
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr
145                 150                 155                 160 
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser
                165                 170                 175     
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn
            180                 185                 190         
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr
        195                 200                 205             
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu
    210                 215                 220                 
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His
225                 230                 235                 240 
Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr
                245                 250                 255     
Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys
            260                 265                 270         
Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu
        275                 280                 285             
Glu Thr
    290 


<210> 2
<211> 417
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu
 1               5                  10                  15      
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln
            20                  25                  30          
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro
        35                  40                  45              
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu
    50                  55                  60                  
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln
65                  70                  75                  80  
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala
                85                  90                  95      
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly
            100                 105                 110         
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe
        115                 120                 125             
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys
    130                 135                 140                 
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro
145                 150                 155                 160 
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln
                165                 170                 175     
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val
            180                 185                 190         
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu
        195                 200                 205             
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu
    210                 215                 220                 
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val
225                 230                 235                 240 
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr
                245                 250                 255     
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro
            260                 265                 270         
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro
        275                 280                 285             
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys
    290                 295                 300                 
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala
305                 310                 315                 320 
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu
                325                 330                 335     
His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile
            340                 345                 350         
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser
        355                 360                 365             
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser
    370                 375                 380                 
Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala
385                 390                 395                 400 
Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr
                405                 410                 415     
Arg
    


<210> 3
<211> 538
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro
 1               5                  10                  15      
Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln
            20                  25                  30          
Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly
        35                  40                  45              
Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr
    50                  55                  60                  
Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln
65                  70                  75                  80  
Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro
                85                  90                  95      
Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr
            100                 105                 110         
Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His
        115                 120                 125             
Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr
    130                 135                 140                 
Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala
145                 150                 155                 160 
Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp
                165                 170                 175     
Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala
            180                 185                 190         
Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln
        195                 200                 205             
Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr
    210                 215                 220                 
Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val
225                 230                 235                 240 
Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser
                245                 250                 255     
Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp
            260                 265                 270         
Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn
        275                 280                 285             
Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro
    290                 295                 300                 
Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp
305                 310                 315                 320 
Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly
                325                 330                 335     
Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr
            340                 345                 350         
Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala
        355                 360                 365             
Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln
    370                 375                 380                 
Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu
385                 390                 395                 400 
Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu
                405                 410                 415     
Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His
            420                 425                 430         
Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu
        435                 440                 445             
Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser
    450                 455                 460                 
Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val
465                 470                 475                 480 
Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp
                485                 490                 495     
Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile
            500                 505                 510         
Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys
        515                 520                 525             
Gly Phe Val Met Ser Arg Ala Met Tyr Val
    530                 535             


<210> 4
<211> 312
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met
 1               5                  10                  15      
Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg
            20                  25                  30          
Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln
        35                  40                  45              
Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp
    50                  55                  60                  
Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr
65                  70                  75                  80  
Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe
                85                  90                  95      
Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys
            100                 105                 110         
Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp
        115                 120                 125             
Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe
    130                 135                 140                 
Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn
145                 150                 155                 160 
Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu
                165                 170                 175     
Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys
            180                 185                 190         
Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser
        195                 200                 205             
Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln
    210                 215                 220                 
Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp
225                 230                 235                 240 
His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp
                245                 250                 255     
Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser
            260                 265                 270         
Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp
        275                 280                 285             
His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro
    290                 295                 300                 
Asn Asp Phe Ile Pro Asn Val Ile
305                 310         


<210> 5
<211> 355
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro
 1               5                  10                  15      
Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr
            20                  25                  30          
Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn
        35                  40                  45              
Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro
    50                  55                  60                  
Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly
65                  70                  75                  80  
Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly
                85                  90                  95      
Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val
            100                 105                 110         
Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe
        115                 120                 125             
His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr
    130                 135                 140                 
Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser
145                 150                 155                 160 
Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly
                165                 170                 175     
Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile
            180                 185                 190         
Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe
        195                 200                 205             
Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro
    210                 215                 220                 
Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser
225                 230                 235                 240 
Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile
                245                 250                 255     
Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe
            260                 265                 270         
Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly
        275                 280                 285             
Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln
    290                 295                 300                 
Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala
305                 310                 315                 320 
Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu
                325                 330                 335     
Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His
            340                 345                 350         
Val Gln Thr
        355 


<210> 6
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6
Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly
 1               5                  10                  15      
Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe
            20                  25                  30          
Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala
        35                  40                  45              
Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp
    50                  55                  60                  
Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp
65                  70                  75                  80  
Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala
                85                  90                  95      
Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr
            100                 105                 110         
Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu
        115                 120                 125             
Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu
    130                 135                 140                 
Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe
145                 150                 155                 160 
Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr
                165                 170                 175     
Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val
            180                 185                 190         
Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr
        195                 200                 205             
Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His
    210                 215                 220                 
Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala
225                 230                 235                 240 
Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu
                245                 250                 255     
Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile
            260                 265                 270         
Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr
        275                 280                 285             
Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys
    290                 295                 300                 
Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met
305                 310                 315                 320 
Asn Asp Glu
            


<210> 7
<211> 534
<212> PRT
<213> Homo sapiens

<400> 7
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala
 1               5                  10                  15      
Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln
            20                  25                  30          
Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu
        35                  40                  45              
Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn
    50                  55                  60                  
Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala
65                  70                  75                  80  
Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe
                85                  90                  95      
Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val
            100                 105                 110         
Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp
        115                 120                 125             
Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys
    130                 135                 140                 
Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr
145                 150                 155                 160 
Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val
                165                 170                 175     
Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr
            180                 185                 190         
Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu
        195                 200                 205             
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
    210                 215                 220                 
Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln
225                 230                 235                 240 
Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val
                245                 250                 255     
Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro
            260                 265                 270         
Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr
        275                 280                 285             
Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly
    290                 295                 300                 
Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln
305                 310                 315                 320 
Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly
                325                 330                 335     
Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val
            340                 345                 350         
Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu
        355                 360                 365             
Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser
    370                 375                 380                 
Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln
385                 390                 395                 400 
Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu
                405                 410                 415     
Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala
            420                 425                 430         
Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp
        435                 440                 445             
Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro
    450                 455                 460                 
Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu
465                 470                 475                 480 
Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys
                485                 490                 495     
Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly
            500                 505                 510         
Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp
        515                 520                 525             
Asp Gly Gln Glu Ile Ala
    530                 


<210> 8
<211> 282
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile
 1               5                  10                  15      
Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser
            20                  25                  30          
Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile
        35                  40                  45              
Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu
    50                  55                  60                  
Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val
65                  70                  75                  80  
His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met
                85                  90                  95      
Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn
            100                 105                 110         
Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr
        115                 120                 125             
Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu
    130                 135                 140                 
Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn
145                 150                 155                 160 
Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln
                165                 170                 175     
Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser
            180                 185                 190         
Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met
        195                 200                 205             
Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser
    210                 215                 220                 
Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val
225                 230                 235                 240 
Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser
                245                 250                 255     
Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu
            260                 265                 270         
Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys
        275                 280         


<210> 9
<211> 486
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg
                485     


<210> 10
<211> 487
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg
                485         


<210> 11
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15      
Glu Glu Asn Pro Gly Pro
            20          


<210> 12
<211> 798
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Phe
            500                 505                 510         
Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu Asn Ala Phe Thr
        515                 520                 525             
Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met
    530                 535                 540                 
Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala
545                 550                 555                 560 
Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val
                565                 570                 575     
His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg
            580                 585                 590         
Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln
        595                 600                 605             
Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile
    610                 615                 620                 
Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala
625                 630                 635                 640 
Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val Thr
                645                 650                 655     
Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala Glu
            660                 665                 670         
Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr Thr
        675                 680                 685             
Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser Thr
    690                 695                 700                 
Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe Arg
705                 710                 715                 720 
Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro Glu
                725                 730                 735     
Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val Ile Leu
            740                 745                 750         
Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile Phe Arg
        755                 760                 765             
Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile Gln Asp
    770                 775                 780                 
Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr
785                 790                 795             


<210> 13
<211> 925
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Arg Ala
            500                 505                 510         
Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu Leu Val Leu Ser
        515                 520                 525             
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
    530                 535                 540                 
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
545                 550                 555                 560 
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
                565                 570                 575     
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
            580                 585                 590         
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
        595                 600                 605             
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
    610                 615                 620                 
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
625                 630                 635                 640 
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
                645                 650                 655     
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
            660                 665                 670         
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
        675                 680                 685             
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
    690                 695                 700                 
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
705                 710                 715                 720 
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
                725                 730                 735     
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
            740                 745                 750         
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
        755                 760                 765             
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
    770                 775                 780                 
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
785                 790                 795                 800 
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
                805                 810                 815     
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
            820                 825                 830         
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
        835                 840                 845             
Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile Leu Val Phe Leu
    850                 855                 860                 
Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser Lys Cys Ser Arg
865                 870                 875                 880 
Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser Thr Glu His Ala
                885                 890                 895     
Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu
            900                 905                 910         
Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg
        915                 920                 925 


<210> 14
<211> 1046
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Arg Ala
            500                 505                 510         
Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro Leu Leu Trp Pro
        515                 520                 525             
Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln Asp Val Arg Val
    530                 535                 540                 
Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly Thr Val Glu Leu
545                 550                 555                 560 
Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr Ile Ser Leu Val
                565                 570                 575     
Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln Asn Val Ala Ala
            580                 585                 590         
Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro Lys Pro Gly Ser
        595                 600                 605             
Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr Gly Gln Asp Thr
    610                 615                 620                 
Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His Gly Leu Thr Val
625                 630                 635                 640 
Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr Phe Pro Lys Gly
                645                 650                 655     
Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala Lys Pro Lys Asn
            660                 665                 670         
Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp Pro Thr Thr Val
        675                 680                 685             
Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala Arg Ile Ser Trp
    690                 695                 700                 
Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln Val Ser Gly Thr
705                 710                 715                 720 
Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr Leu Val Pro Ser
                725                 730                 735     
Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val Glu His Glu Ser
            740                 745                 750         
Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser Val Arg Tyr Pro
        755                 760                 765             
Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp Tyr Leu Gly Arg
    770                 775                 780                 
Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn Pro Glu Pro Thr
785                 790                 795                 800 
Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro Thr Ser Ala Val
                805                 810                 815     
Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp Ser Leu Phe Asn
            820                 825                 830         
Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly Met Gly Arg Ala
        835                 840                 845             
Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr Ala Gly Ala Gly
    850                 855                 860                 
Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala Ile Ile Ala Thr
865                 870                 875                 880 
Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln Gln Arg Lys Glu
                885                 890                 895     
Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu Glu Gly Pro Pro
            900                 905                 910         
Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu Ala Gln Glu Met
        915                 920                 925             
Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His Ser Pro Leu Lys
    930                 935                 940                 
Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu Gln Glu Met Pro
945                 950                 955                 960 
Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser Gly Pro Leu His
                965                 970                 975     
Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val Pro Pro Gly Pro
            980                 985                 990         
Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp Glu Glu Gly Glu
        995                 1000                1005            
Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile Tyr Asp Ala Leu
    1010                1015                1020                
Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys Gly Phe Val Met
1025                1030                1035               1040 
Ser Arg Ala Met Tyr Val
                1045    


<210> 15
<211> 820
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Lys Val
            500                 505                 510         
Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met Gly Arg Glu Ile
        515                 520                 525             
Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg Leu Arg Ala Gln
    530                 535                 540                 
Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln Val Lys Ile Lys
545                 550                 555                 560 
Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp Lys Gly Asp Glu
                565                 570                 575     
Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr Ala Asp Cys Ser
            580                 585                 590         
Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe Tyr Lys Ile Lys
        595                 600                 605             
Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys Asp Met Ser Asp
    610                 615                 620                 
Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp Gly Ser Glu Asn
625                 630                 635                 640 
Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe Gly Asn Phe Val
                645                 650                 655     
Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn Leu His Phe Leu
            660                 665                 670         
Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu Ala Asp Phe Glu
        675                 680                 685             
Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys Val Gly Asp Glu
    690                 695                 700                 
Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser Gly Thr Ala Gly
705                 710                 715                 720 
Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln Trp Trp Ala Ser
                725                 730                 735     
His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp His Asp Asn Tyr
            740                 745                 750         
Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp Trp Phe Asn Arg
        755                 760                 765             
Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser Gly Pro Tyr Thr
    770                 775                 780                 
Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp His Gly Trp Trp
785                 790                 795                 800 
Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro Asn Asp Phe Ile
                805                 810                 815     
Pro Asn Val Ile
            820 


<210> 16
<211> 863
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Phe Ser
            500                 505                 510         
Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro Phe Ser Gly Thr
        515                 520                 525             
Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr Val Asn Gly Thr
    530                 535                 540                 
Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn Phe Gln Thr Gly
545                 550                 555                 560 
Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg Phe Glu Asp
                565                 570                 575     
Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly Ser Trp Gly Pro
            580                 585                 590         
Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly Met Pro Phe Asp
        595                 600                 605             
Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val Met Val Asn Gly
    610                 615                 620                 
Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe His Arg Val Asp
625                 630                 635                 640 
Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr Ile Ser Phe Gln
                645                 650                 655     
Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser Thr Val Pro Phe
            660                 665                 670         
Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly Arg Arg Gln Lys
        675                 680                 685             
Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile Thr Gln Thr Val
    690                 695                 700                 
Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe Ser Thr Pro Ala
705                 710                 715                 720 
Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro Met Pro Phe Ile
                725                 730                 735     
Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser Ile Leu Leu Ser
            740                 745                 750         
Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile Asn Leu Cys Ser
        755                 760                 765             
Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu Asn Ala
    770                 775                 780                 
Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly Ser Glu Glu Arg
785                 790                 795                 800 
Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln Ser Phe Ser Val
                805                 810                 815     
Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala Val Asp Gly Gln
            820                 825                 830         
His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu Pro Thr Ile Asn
        835                 840                 845             
Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His Val Gln Thr
    850                 855                 860             


<210> 17
<211> 831
<212> PRT
<213> Homo sapiens

<400> 17
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Pro Leu
            500                 505                 510         
Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly Ser Ala Gln Leu
        515                 520                 525             
Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn Asp Thr
    530                 535                 540                 
Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn Thr Thr
545                 550                 555                 560 
Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr Thr Phe
                565                 570                 575     
Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser Ser Ala
            580                 585                 590         
Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu Lys Met
        595                 600                 605             
Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys Glu Val
    610                 615                 620                 
Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys Tyr Arg
625                 630                 635                 640 
Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val Ile Phe
                645                 650                 655     
Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile Lys Thr
            660                 665                 670         
Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala Leu Leu
        675                 680                 685             
Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala Ile Leu
    690                 695                 700                 
Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu Gly Leu
705                 710                 715                 720 
Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr Val Phe
                725                 730                 735     
Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu Val Ile
            740                 745                 750         
Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu Cys Ile
        755                 760                 765             
Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly Leu Ser
    770                 775                 780                 
Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys Phe Val
785                 790                 795                 800 
Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val Glu Glu
                805                 810                 815     
Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp Glu
            820                 825                 830     


<210> 18
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Arg Arg
            500                 505                 510         
Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala Ala Leu Gly Ala
        515                 520                 525             
Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln Val Pro Glu Asp
    530                 535                 540                 
Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Cys Cys Ser Phe
545                 550                 555                 560 
Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln
                565                 570                 575     
Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala Glu Gly Gln Asp
            580                 585                 590         
Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu
        595                 600                 605             
Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp
    610                 615                 620                 
Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala
625                 630                 635                 640 
Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr
                645                 650                 655     
Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr
            660                 665                 670         
Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp
        675                 680                 685             
Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala
    690                 695                 700                 
Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu Arg Val Val Leu
705                 710                 715                 720 
Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln
                725                 730                 735     
Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln Arg Ser Pro Thr
            740                 745                 750         
Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val
        755                 760                 765             
Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe
    770                 775                 780                 
Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln
785                 790                 795                 800 
Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ala
                805                 810                 815     
Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser
            820                 825                 830         
Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys
        835                 840                 845             
Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val
    850                 855                 860                 
Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp
865                 870                 875                 880 
Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly
                885                 890                 895     
Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu
            900                 905                 910         
Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe
        915                 920                 925             
Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr
    930                 935                 940                 
Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Gly Ser
945                 950                 955                 960 
Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu Ala Leu Trp
                965                 970                 975     
Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val Ala Leu
            980                 985                 990         
Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn
        995                 1000                1005            
Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala
    1010                1015                1020                
Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu
1025                1030                1035               1040 
Ile Ala
        


<210> 19
<211> 790
<212> PRT
<213> Homo sapiens

<400> 19
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
    50                  55                  60                  
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
                85                  90                  95      
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
            100                 105                 110         
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
    130                 135                 140                 
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145                 150                 155                 160 
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
                165                 170                 175     
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
            180                 185                 190         
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
        195                 200                 205             
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
    210                 215                 220                 
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225                 230                 235                 240 
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
                245                 250                 255     
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
            260                 265                 270         
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
        275                 280                 285             
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
    290                 295                 300                 
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305                 310                 315                 320 
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
                325                 330                 335     
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
            340                 345                 350         
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
        355                 360                 365             
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
    370                 375                 380                 
Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385                 390                 395                 400 
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
                405                 410                 415     
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu
                485                 490                 495     
Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Leu
            500                 505                 510         
Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile Ile Ile Leu Ala
        515                 520                 525             
Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser
    530                 535                 540                 
Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly
545                 550                 555                 560 
Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val
                565                 570                 575     
Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys
            580                 585                 590         
Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg
        595                 600                 605             
Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg
    610                 615                 620                 
Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile
625                 630                 635                 640 
Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly
                645                 650                 655     
Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu
            660                 665                 670         
Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val
        675                 680                 685             
Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn
    690                 695                 700                 
Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser
705                 710                 715                 720 
Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu
                725                 730                 735     
Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu
            740                 745                 750         
Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu
        755                 760                 765             
Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser
    770                 775                 780                 
Pro Tyr Leu Met Leu Lys
785                 790 


<210> 20
<211> 799
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile
            500                 505                 510         
Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu Asn Ala Phe
        515                 520                 525             
Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn
    530                 535                 540                 
Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala
545                 550                 555                 560 
Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe
                565                 570                 575     
Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln
            580                 585                 590         
Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu
        595                 600                 605             
Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met
    610                 615                 620                 
Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn
625                 630                 635                 640 
Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro Val
                645                 650                 655     
Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys Ala
            660                 665                 670         
Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys Thr
        675                 680                 685             
Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr Ser
    690                 695                 700                 
Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe
705                 710                 715                 720 
Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro
                725                 730                 735     
Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val Ile
            740                 745                 750         
Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile Phe
        755                 760                 765             
Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile Gln
    770                 775                 780                 
Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr
785                 790                 795                 


<210> 21
<211> 926
<212> PRT
<213> Homo sapiens

<400> 21
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Arg
            500                 505                 510         
Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu Leu Val Leu
        515                 520                 525             
Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr
    530                 535                 540                 
Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu
545                 550                 555                 560 
Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala
                565                 570                 575     
Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly
            580                 585                 590         
Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu
        595                 600                 605             
Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val
    610                 615                 620                 
Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly
625                 630                 635                 640 
Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn
                645                 650                 655     
Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met
            660                 665                 670         
Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp
        675                 680                 685             
His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe
    690                 695                 700                 
Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser
705                 710                 715                 720 
Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser
                725                 730                 735     
Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro
            740                 745                 750         
Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln
        755                 760                 765             
Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr
    770                 775                 780                 
Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val
785                 790                 795                 800 
Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn
                805                 810                 815     
Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala
            820                 825                 830         
Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly
        835                 840                 845             
Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile Leu Val Phe
    850                 855                 860                 
Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser Lys Cys Ser
865                 870                 875                 880 
Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser Thr Glu His
                885                 890                 895     
Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg
            900                 905                 910         
Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg
        915                 920                 925     


<210> 22
<211> 1047
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Arg
            500                 505                 510         
Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro Leu Leu Trp
        515                 520                 525             
Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln Asp Val Arg
    530                 535                 540                 
Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly Thr Val Glu
545                 550                 555                 560 
Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr Ile Ser Leu
                565                 570                 575     
Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln Asn Val Ala
            580                 585                 590         
Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro Lys Pro Gly
        595                 600                 605             
Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr Gly Gln Asp
    610                 615                 620                 
Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His Gly Leu Thr
625                 630                 635                 640 
Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr Phe Pro Lys
                645                 650                 655     
Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala Lys Pro Lys
            660                 665                 670         
Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp Pro Thr Thr
        675                 680                 685             
Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala Arg Ile Ser
    690                 695                 700                 
Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln Val Ser Gly
705                 710                 715                 720 
Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr Leu Val Pro
                725                 730                 735     
Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val Glu His Glu
            740                 745                 750         
Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser Val Arg Tyr
        755                 760                 765             
Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp Tyr Leu Gly
    770                 775                 780                 
Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn Pro Glu Pro
785                 790                 795                 800 
Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro Thr Ser Ala
                805                 810                 815     
Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp Ser Leu Phe
            820                 825                 830         
Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly Met Gly Arg
        835                 840                 845             
Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr Ala Gly Ala
    850                 855                 860                 
Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala Ile Ile Ala
865                 870                 875                 880 
Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln Gln Arg Lys
                885                 890                 895     
Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu Glu Gly Pro
            900                 905                 910         
Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu Ala Gln Glu
        915                 920                 925             
Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His Ser Pro Leu
    930                 935                 940                 
Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu Gln Glu Met
945                 950                 955                 960 
Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser Gly Pro Leu
                965                 970                 975     
His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val Pro Pro Gly
            980                 985                 990         
Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp Glu Glu Gly
        995                 1000                1005            
Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile Tyr Asp Ala
    1010                1015                1020                
Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys Gly Phe Val
1025                1030                1035               1040 
Met Ser Arg Ala Met Tyr Val
                1045        


<210> 23
<211> 821
<212> PRT
<213> Homo sapiens

<400> 23
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Lys
            500                 505                 510         
Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met Gly Arg Glu
        515                 520                 525             
Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg Leu Arg Ala
    530                 535                 540                 
Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln Val Lys Ile
545                 550                 555                 560 
Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp Lys Gly Asp
                565                 570                 575     
Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr Ala Asp Cys
            580                 585                 590         
Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe Tyr Lys Ile
        595                 600                 605             
Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys Asp Met Ser
    610                 615                 620                 
Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp Gly Ser Glu
625                 630                 635                 640 
Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe Gly Asn Phe
                645                 650                 655     
Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn Leu His Phe
            660                 665                 670         
Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu Ala Asp Phe
        675                 680                 685             
Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys Val Gly Asp
    690                 695                 700                 
Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser Gly Thr Ala
705                 710                 715                 720 
Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln Trp Trp Ala
                725                 730                 735     
Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp His Asp Asn
            740                 745                 750         
Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp Trp Phe Asn
        755                 760                 765             
Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser Gly Pro Tyr
    770                 775                 780                 
Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp His Gly Trp
785                 790                 795                 800 
Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro Asn Asp Phe
                805                 810                 815     
Ile Pro Asn Val Ile
            820     


<210> 24
<211> 864
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Phe
            500                 505                 510         
Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro Phe Ser Gly
        515                 520                 525             
Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr Val Asn Gly
    530                 535                 540                 
Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn Phe Gln Thr
545                 550                 555                 560 
Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg Phe Glu
                565                 570                 575     
Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly Ser Trp Gly
            580                 585                 590         
Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly Met Pro Phe
        595                 600                 605             
Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val Met Val Asn
    610                 615                 620                 
Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe His Arg Val
625                 630                 635                 640 
Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr Ile Ser Phe
                645                 650                 655     
Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser Thr Val Pro
            660                 665                 670         
Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly Arg Arg Gln
        675                 680                 685             
Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile Thr Gln Thr
    690                 695                 700                 
Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe Ser Thr Pro
705                 710                 715                 720 
Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro Met Pro Phe
                725                 730                 735     
Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser Ile Leu Leu
            740                 745                 750         
Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile Asn Leu Cys
        755                 760                 765             
Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe Asp Glu Asn
    770                 775                 780                 
Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly Ser Glu Glu
785                 790                 795                 800 
Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln Ser Phe Ser
                805                 810                 815     
Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala Val Asp Gly
            820                 825                 830         
Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu Pro Thr Ile
        835                 840                 845             
Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His Val Gln Thr
    850                 855                 860                 


<210> 25
<211> 832
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp Pro
            500                 505                 510         
Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly Ser Ala Gln
        515                 520                 525             
Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn Asp
    530                 535                 540                 
Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn Thr
545                 550                 555                 560 
Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr Thr
                565                 570                 575     
Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser Ser
            580                 585                 590         
Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu Lys
        595                 600                 605             
Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys Glu
    610                 615                 620                 
Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys Tyr
625                 630                 635                 640 
Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val Ile
                645                 650                 655     
Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile Lys
            660                 665                 670         
Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala Leu
        675                 680                 685             
Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala Ile
    690                 695                 700                 
Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu Gly
705                 710                 715                 720 
Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr Val
                725                 730                 735     
Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu Val
            740                 745                 750         
Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu Cys
        755                 760                 765             
Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly Leu
    770                 775                 780                 
Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys Phe
785                 790                 795                 800 
Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val Glu
                805                 810                 815     
Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp Glu
            820                 825                 830         


<210> 26
<211> 1043
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Arg
            500                 505                 510         
Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala Ala Leu Gly
        515                 520                 525             
Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln Val Pro Glu
    530                 535                 540                 
Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Cys Cys Ser
545                 550                 555                 560 
Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp
                565                 570                 575     
Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala Glu Gly Gln
            580                 585                 590         
Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu
        595                 600                 605             
Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala
    610                 615                 620                 
Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser
625                 630                 635                 640 
Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met
                645                 650                 655     
Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile
            660                 665                 670         
Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln
        675                 680                 685             
Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met
    690                 695                 700                 
Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu Arg Val Val
705                 710                 715                 720 
Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu
                725                 730                 735     
Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln Arg Ser Pro
            740                 745                 750         
Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu
        755                 760                 765             
Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro Glu Pro Gly
    770                 775                 780                 
Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys
785                 790                 795                 800 
Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly Ser Ala Tyr
                805                 810                 815     
Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala
            820                 825                 830         
Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr
        835                 840                 845             
Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln
    850                 855                 860                 
Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys
865                 870                 875                 880 
Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Arg
                885                 890                 895     
Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro
            900                 905                 910         
Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu
        915                 920                 925             
Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala Asn Gly Thr
    930                 935                 940                 
Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Gly
945                 950                 955                 960 
Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro Glu Ala Leu
                965                 970                 975     
Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu Leu Val Ala
            980                 985                 990         
Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys Glu Glu Glu
        995                 1000                1005            
Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly Ser Lys Thr
    1010                1015                1020                
Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp Asp Gly Gln
1025                1030                1035               1040 
Glu Ile Ala
            


<210> 27
<211> 791
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg
        35                  40                  45              
Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly
        115                 120                 125             
Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn
                165                 170                 175     
Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser
            180                 185                 190         
Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys
225                 230                 235                 240 
Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro
            260                 265                 270         
Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
        275                 280                 285             
Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
    290                 295                 300                 
Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
305                 310                 315                 320 
Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly
                325                 330                 335     
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
            340                 345                 350         
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
        355                 360                 365             
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
    370                 375                 380                 
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385                 390                 395                 400 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
                405                 410                 415     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
            420                 425                 430         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
        435                 440                 445             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
    450                 455                 460                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465                 470                 475                 480 
Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu
                485                 490                 495     
Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser
            500                 505                 510         
Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile Ile Ile Leu
        515                 520                 525             
Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His
    530                 535                 540                 
Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp
545                 550                 555                 560 
Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile
                565                 570                 575     
Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe
            580                 585                 590         
Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly
        595                 600                 605             
Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu
    610                 615                 620                 
Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr
625                 630                 635                 640 
Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr
                645                 650                 655     
Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser
            660                 665                 670         
Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val
        675                 680                 685             
Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser
    690                 695                 700                 
Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val
705                 710                 715                 720 
Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile
                725                 730                 735     
Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser
            740                 745                 750         
Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser
        755                 760                 765             
Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu
    770                 775                 780                 
Ser Pro Tyr Leu Met Leu Lys
785                 790     

