                               SEQUENCE LISTING

<110> ARROWHEAD PHARMACEUTICALS, INC.

<120> RNAI AGENTS FOR INHIBITING EXPRESSION OF PNPLA3, PHARMACEUTICAL 
      COMPOSITIONS THEREOF, AND METHODS OF USE

<130> 103693.002475 PCT

<140>
<141>

<150> 63/000,137
<151> 2020-03-26

<160> 258   

<170> PatentIn version 3.5

<210> 1
<211> 2805
<212> DNA
<213> Homo sapiens

<400> 1
atggtccgag gggggcgggg ctgacgtcgc gctgggaatg ccctggccga gacactgagg       60

cagggtagag agcgcttgcg ggcgccgggc ggagctgctg cggatcagga cccgagccga      120

ttcccgatcc cgacccagat cctaacccgc gcccccgccc cgccgccgcc gccatgtacg      180

acgcagagcg cggctggagc ttgtccttcg cgggctgcgg cttcctgggc ttctaccacg      240

tcggggcgac ccgctgcctg agcgagcacg ccccgcacct cctccgcgac gcgcgcatgt      300

tgttcggcgc ttcggccggg gcgttgcact gcgtcggcgt cctctccggt atcccgctgg      360

agcagactct gcaggtcctc tcagatcttg tgcggaaggc caggagtcgg aacattggca      420

tcttccatcc atccttcaac ttaagcaagt tcctccgaca gggtctctgc aaatgcctcc      480

cggccaatgt ccaccagctc atctccggca aaataggcat ctctcttacc agagtgtctg      540

atggggaaaa cgttctggtg tctgactttc ggtccaaaga cgaagtcgtg gatgccttgg      600

tatgttcctg cttcatcccc ttctacagtg gccttatccc tccttccttc agaggcgtgc      660

gatatgtgga tggaggagtg agtgacaacg tacccttcat tgatgccaaa acaaccatca      720

ccgtgtcccc cttctatggg gagtacgaca tctgccctaa agtcaagtcc acgaactttc      780

ttcatgtgga catcaccaag ctcagtctac gcctctgcac agggaacctc taccttctct      840

cgagagcttt tgtccccccg gatctcaagg tgctgggaga gatatgcctt cgaggatatt      900

tggatgcatt caggttcttg gaagagaagg gcatctgcaa caggccccag ccaggcctga      960

agtcatcctc agaagggatg gatcctgagg tcgccatgcc cagctgggca aacatgagtc     1020

tggattcttc cccggagtcg gctgccttgg ctgtgaggct ggagggagat gagctgctag     1080

accacctgcg tctcagcatc ctgccctggg atgagagcat cctggacacc ctctcgccca     1140

ggctcgctac agcactgagt gaagaaatga aagacaaagg tggatacatg agcaagattt     1200

gcaacttgct acccattagg ataatgtctt atgtaatgct gccctgtacc ctgcctgtgg     1260

aatctgccat tgcgattgtc cagagactgg tgacatggct tccagatatg cccgacgatg     1320

tcctgtggtt gcagtgggtg acctcacagg tgttcactcg agtgctgatg tgtctgctcc     1380

ccgcctccag gtcccaaatg ccagtgagca gccaacaggc ctccccatgc acacctgagc     1440

aggactggcc ctgctggact ccctgctccc ccaagggctg tccagcagag accaaagcag     1500

aggccacccc gcggtccatc ctcaggtcca gcctgaactt cttcttgggc aataaagtac     1560

ctgctggtgc tgaggggctc tccacctttc ccagtttttc actagagaag agtctgtgag     1620

tcacttgagg aggcgagtct agcagattct ttcagaggtg ctaaagtttc ccatctttgt     1680

gcagctacct ccgcattgct gtgtagtgac ccctgcctgt gacgtggagg atcccagcct     1740

ctgagctgag ttggttttat gaaaagctag gaagcaacct ttcgcctgtg cagcggtcca     1800

gcacttaact ctaatacatc agcatgcgtt aattcagctg gttgggaaat gacaccagga     1860

agcccagtgc agagggtccc ttactgactg tttcgtggcc ctattaatgg tcagactgtt     1920

ccagcatgag gttcttagaa tgacaggtgt ttggatgggt gggggccttg tgatgggggg     1980

taggctggcc catgtgtgat cttgtggggt ggagggaaga gaatagcatg atcccacttc     2040

cccatgctgt gggaaggggt gcagttcgtc cccaagaacg acactgcctg tcaggtggtc     2100

tgcaaagatg ataaccttga ctactaaaaa cgtctccatg gcgggggtaa caagatgata     2160

atctacttaa ttttagaaca cctttttcac ctaactaaaa taatgtttaa agagttttgt     2220

ataaaaatgt aaggaagcgt tgttacctgt tgaattttgt attatgtgaa tcagtgagat     2280

gttagtagaa taagccttaa aaaaaaaaaa atcggttggg tgcagtggca cacggctgta     2340

atcccagcac tttgggaggc caaggttggc agatcacctg aggtcaggag ttcaagacca     2400

gtctggccaa catagcaaaa ccctgtctct actaaaaata caaaaattat ctgggcatgg     2460

tggtgcatgc ctgtaatccc agctattcgg aaggctgagg caggagaatc acttgaaccc     2520

aggaggcgga ggttgcggtg agctgagatt gcaccatttc attccagcct gggcaacatg     2580

agtgaaagtc tgactcaaaa aaaaaaaatt taaaaaacaa aataatctag tgtgcagggc     2640

attcacctca gccccccagg caggagccaa gcacagcagg agcttccgcc tcctctccac     2700

tggagcacac aacttgaacc tggcttattt tctgcaggga ccagccccac atggtcagtg     2760

agtttctccc catgtgtggc gatgagagag tgtagaaata aagac                     2805


<210> 2
<211> 19
<212> RNA
<213> Homo sapiens

<400> 2
accuuuuuca ccuaacuaa                                                    19


<210> 3
<211> 19
<212> RNA
<213> Homo sapiens

<400> 3
cuuucccagu uuuucacua                                                    19


<210> 4
<211> 19
<212> RNA
<213> Homo sapiens

<400> 4
gguggauaca ugagcaaga                                                    19


<210> 5
<211> 19
<212> RNA
<213> Homo sapiens

<400> 5
gguccaaaga cgaagucgu                                                    19


<210> 6
<211> 19
<212> RNA
<213> Homo sapiens

<400> 6
aacguacccu ucauugaug                                                    19


<210> 7
<211> 19
<212> RNA
<213> Homo sapiens

<400> 7
cugaguuggu uuuaugaaa                                                    19


<210> 8
<211> 19
<212> RNA
<213> Homo sapiens

<400> 8
agcaagauuu gcaacuugc                                                    19


<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 9
accuuuuuca ccuaacuan                                                    19


<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 10
nccuuuuuca ccuaacuan                                                    19


<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (18)..(18)
<223> 2-aminoadenine nucleotide

<400> 11
accuuuuuca ccuaacuaa                                                    19


<210> 12
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (18)..(18)
<223> 2-aminoadenine nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 12
accuuuuuca ccuaacuan                                                    19


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (18)..(18)
<223> 2-aminoadenine nucleotide

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 13
nccuuuuuca ccuaacuan                                                    19


<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 14
cuuucccagu uuuucacun                                                    19


<210> 15
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 15
nuuucccagu uuuucacun                                                    19


<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 16
gguggauaca ugagcaagn                                                    19


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 17
nguggauaca ugagcaagn                                                    19


<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (14)..(14)
<223> Hypoxanthine

<400> 18
gguggauaca ugancaaga                                                    19


<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (14)..(14)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 19
gguggauaca ugancaagn                                                    19


<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (14)..(14)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 20
nguggauaca ugancaagn                                                    19


<210> 21
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
gguccaaaga cgaagucga                                                    19


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 22
gguccaaaga cgaagucgn                                                    19


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 23
nguccaaaga cgaagucgn                                                    19


<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<400> 24
gguccaaaga cgaagucnu                                                    19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<400> 25
gguccaaaga cgaagucna                                                    19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 26
gguccaaaga cgaagucnn                                                    19


<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 27
nguccaaaga cgaagucnn                                                    19


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (12)..(12)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<400> 28
gguccaaaga cnaagucnu                                                    19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (12)..(12)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<400> 29
gguccaaaga cnaagucna                                                    19


<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (12)..(12)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 30
gguccaaaga cnaagucnn                                                    19


<210> 31
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (12)..(12)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (18)..(18)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 31
nguccaaaga cnaagucnn                                                    19


<210> 32
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (15)..(15)
<223> Hypoxanthine

<400> 32
gguccaaaga cgaanucgu                                                    19


<210> 33
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (15)..(15)
<223> Hypoxanthine

<400> 33
gguccaaaga cgaanucga                                                    19


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (15)..(15)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 34
gguccaaaga cgaanucgn                                                    19


<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (15)..(15)
<223> Hypoxanthine

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 35
nguccaaaga cgaanucgn                                                    19


<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
aacguacccu ucauugaua                                                    19


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 37
aacguacccu ucauugaun                                                    19


<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 38
nacguacccu ucauugaun                                                    19


<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 39
cugaguuggu uuuaugaan                                                    19


<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 40
nugaguuggu uuuaugaan                                                    19


<210> 41
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 41
agcaagauuu gcaacuuga                                                    19


<210> 42
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 42
cgcaagauuu gcaacuuga                                                    19


<210> 43
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 43
agcaagauuu gcaacuugn                                                    19


<210> 44
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 44
cgcaagauuu gcaacuugn                                                    19


<210> 45
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 45
ngcaagauuu gcaacuugn                                                    19


<210> 46
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 46
uuaguuaggu gaaaaaggu                                                    19


<210> 47
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 47
nuaguuaggu gaaaaaggu                                                    19


<210> 48
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 48
nuaguuaggu gaaaaaggn                                                    19


<210> 49
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
uuaguuaggu gaaaaaggu                                                    19


<210> 50
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 50
nuaguuaggu gaaaaaggu                                                    19


<210> 51
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 51
nuaguuaggu gaaaaaggn                                                    19


<210> 52
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 52
uagugaaaaa cugggaaag                                                    19


<210> 53
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 53
nagugaaaaa cugggaaag                                                    19


<210> 54
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 54
nagugaaaaa cugggaaan                                                    19


<210> 55
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 55
ucuugcucau guauccacc                                                    19


<210> 56
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 56
ncuugcucau guauccacc                                                    19


<210> 57
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 57
ncuugcucau guauccacn                                                    19


<210> 58
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 58
ucuugcucau guauccacc                                                    19


<210> 59
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 59
ncuugcucau guauccacc                                                    19


<210> 60
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 60
ncuugcucau guauccacn                                                    19


<210> 61
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 61
acgacuucgu cuuuggacc                                                    19


<210> 62
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 62
ucgacuucgu cuuuggacc                                                    19


<210> 63
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 63
ncgacuucgu cuuuggacc                                                    19


<210> 64
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 64
ncgacuucgu cuuuggacn                                                    19


<210> 65
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 65
acgacuucgu cuuuggacc                                                    19


<210> 66
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 66
ucgacuucgu cuuuggacc                                                    19


<210> 67
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 67
ncgacuucgu cuuuggacc                                                    19


<210> 68
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 68
ncgacuucgu cuuuggacn                                                    19


<210> 69
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 69
acgacuucgu cuuuggacc                                                    19


<210> 70
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 70
ucgacuucgu cuuuggacc                                                    19


<210> 71
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 71
ncgacuucgu cuuuggacc                                                    19


<210> 72
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 72
ncgacuucgu cuuuggacn                                                    19


<210> 73
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 73
acgacuucgu cuuuggacc                                                    19


<210> 74
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 74
ucgacuucgu cuuuggacc                                                    19


<210> 75
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 75
ncgacuucgu cuuuggacc                                                    19


<210> 76
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 76
ncgacuucgu cuuuggacn                                                    19


<210> 77
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 77
naucaaugaa ggguacguu                                                    19


<210> 78
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
uaucaaugaa ggguacguu                                                    19


<210> 79
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 79
naucaaugaa ggguacgun                                                    19


<210> 80
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 80
nuucauaaaa ccaacucag                                                    19


<210> 81
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 81
nuucauaaaa ccaacucan                                                    19


<210> 82
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 82
gcaaguugca aaucuugcu                                                    19


<210> 83
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 83
ucaaguugca aaucuugcu                                                    19


<210> 84
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 84
ucaaguugca aaucuugcg                                                    19


<210> 85
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 85
ncaaguugca aaucuugcu                                                    19


<210> 86
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<400> 86
ncaaguugca aaucuugcg                                                    19


<210> 87
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> Any nucleobase

<220>
<221> modified_base
<222> (19)..(19)
<223> Any nucleobase

<400> 87
ncaaguugca aaucuugcn                                                    19


<210> 88
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 88
ucaucaauga aggguacguu g                                                 21


<210> 89
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 89
ucaucaauga aggguacguc g                                                 21


<210> 90
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 90
uagugaaaaa cugggaaagg u                                                 21


<210> 91
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 91
uagugaaaaa cugggaaagg g                                                 21


<210> 92
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 92
aaaucuugcu cauguaucca c                                                 21


<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 93
uacuugacuu uagggcagau g                                                 21


<210> 94
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 94
uacuugacuu uagggcagac g                                                 21


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 95
uuaguuaggu gaaaaaggug u                                                 21


<210> 96
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 96
ucuugcucau guauccaccu g                                                 21


<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<400> 97
acgacuucgu cuuuggaccg a                                                 21


<210> 98
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 98
uaucaaugaa ggguacguug g                                                 21


<210> 99
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 99
uccaaauauc cucgaaggca g                                                 21


<210> 100
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 100
uugaaaaacu gggaaaggug g                                                 21


<210> 101
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 101
uucauaaaac caacucagcu c                                                 21


<210> 102
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 102
ucuugcucau guauccaccu g                                                 21


<210> 103
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 103
agaacguuuu ccccaucaga c                                                 21


<210> 104
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 104
agaacguuuu ccccaucagu u                                                 21


<210> 105
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<400> 105
uacaccagaa cguuuucccc a                                                 21


<210> 106
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 106
ugaaagucag acaccagaac g                                                 21


<210> 107
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 107
uaaggguacg uugucacuca c                                                 21


<210> 108
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 108
uacuuuaggg cagaugucgu g                                                 21


<210> 109
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 109
uguagcaagu ugcaaaucuc g                                                 21


<210> 110
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<400> 110
acgacuucgu cuuuggaccg a                                                 21


<210> 111
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 111
acaagaucug agaggaccug c                                                 21


<210> 112
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 112
ucaaugaagg guacguuguc g                                                 21


<210> 113
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 113
aaucuugcuc auguauccac c                                                 21


<210> 114
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 114
uugucauuuc ccaaccagcu g                                                 21


<210> 115
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroadenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 115
uagugaaaaa cugggaaagg c                                                 21


<210> 116
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 116
ucuugcucau guauccaccu u                                                 21


<210> 117
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 117
ucuugcucau guauccaccu c                                                 21


<210> 118
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 118
uuaguuaggu gaaaaaggug c                                                 21


<210> 119
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5'-cyclopropyl phosphonate-2'-O-methyl uridine-3'
      -phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 119
uuaguuaggu gaaaaaggug u                                                 21


<210> 120
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2',3'-seco-uridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 120
uuaguuaggu gaaaaaggug u                                                 21


<210> 121
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2',3'-seco-adenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 121
uuaguuaggu gaaaaaggug u                                                 21


<210> 122
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2',3'-seco-guanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 122
uuaguuaggu gaaaaaggug u                                                 21


<210> 123
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<400> 123
auccaaauau ccucgaaggc a                                                 21


<210> 124
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 124
ucauguaucc accuuugucu u                                                 21


<210> 125
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluoroguanosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<400> 125
ugcaaaucuu gcucauguau c                                                 21


<210> 126
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<400> 126
ucaaguugca aaucuugcuc a                                                 21


<210> 127
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<400> 127
ucaaguugca aaucuugcuc g                                                 21


<210> 128
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-fluorouridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-fluorocytidine-3'-phosphorothioate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<400> 128
uuucauaaaa ccaacucagc u                                                 21


<210> 129
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 129
ncaacguacc cuucauugau gan                                               23


<210> 130
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 130
ncgacguacc cuucauugau gan                                               23


<210> 131
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 131
naccuuuccc aguuuuucac uan                                               23


<210> 132
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 132
ncccuuuccc aguuuuucac uan                                               23


<210> 133
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 133
nguggauaca ugagcaagau uun                                               23


<210> 134
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 134
ncaucugccc uaaagucaag uan                                               23


<210> 135
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 135
ncgucugccc uaaagucaag uan                                               23


<210> 136
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 136
nacaccuuuu ucaccuaacu aan                                               23


<210> 137
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 137
ncagguggau acaugagcaa gan                                               23


<210> 138
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 138
ncagguggau acaugancaa gan                                               23


<210> 139
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 139
nucgguccaa agacgaaguc nun                                               23


<210> 140
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 140
nccaacguac ccuucauuga uan                                               23


<210> 141
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 141
ncugccuucg aggauauuun gan                                               23


<210> 142
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 142
nccaccuuuc ccaguuuuuc aan                                               23


<210> 143
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 143
ngagcugagu ugguuuuaug aan                                               23


<210> 144
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 144
ngucugaugg ggaaaacguu cun                                               23


<210> 145
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 145
ncugaugggg aaaacguucu uun                                               23


<210> 146
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 146
nuggggaaaa cguucugnug uan                                               23


<210> 147
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 147
ncguucuggu gucugacuuu can                                               23


<210> 148
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 148
ngugagugac aacguacccu uan                                               23


<210> 149
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 149
ncacgacauc ugcccuaaag uan                                               23


<210> 150
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 150
ncgagauuug caacuuncua can                                               23


<210> 151
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 151
nucgguccaa agacgaaguc gun                                               23


<210> 152
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 152
nucgguccaa agacgaanuc gun                                               23


<210> 153
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 153
nccaccuuuu ucaccuaacu aan                                               23


<210> 154
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 154
ngcagnuccu cucagaucuu gun                                               23


<210> 155
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 155
ncgacaacgu acccuucauu gan                                               23


<210> 156
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 156
ngguggauac augagcaaga uun                                               23


<210> 157
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 157
ncagcugguu gggaaaugac aan                                               23


<210> 158
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 158
ngccuuuccc aguuuuucac uan                                               23


<210> 159
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 159
naagguggau acaugancaa gan                                               23


<210> 160
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 160
ngagguggau acaugancaa gan                                               23


<210> 161
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methylinosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 161
naagguggau acaugancaa gan                                               23


<210> 162
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 162
ngcaccuuuu ucaccuaacu aan                                               23


<210> 163
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 163
ngcaccuuuu ucaccuaacu aan                                               23


<210> 164
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 164
nacaccuuuu ucaccuaacu aan                                               23


<210> 165
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 165
nacaccuuuu ucaccuaacu aan                                               23


<210> 166
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 166
nacaccuuuu ucaccuaacu aan                                               23


<210> 167
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 167
nacaccuuuu ucaccuaacu aan                                               23


<210> 168
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyluridine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 168
nugccuucga ggauauuugg aun                                               23


<210> 169
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 169
naagacaaag guggauacau gan                                               23


<210> 170
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methyl-2-aminoadenosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorocytidine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 170
ngauacauga gcaagauuug can                                               23


<210> 171
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 171
nugagcaaga uuugcaacuu gan                                               23


<210> 172
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluoroadenosine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 172
ncgagcaaga uuugcaacuu gan                                               23


<210> 173
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> source
<223> /note="5'-NAG37-phosphorothioate"

<220>
<221> modified_base
<222> (1)..(1)
<223> inverted abasic deoxyribonucleotide-5'-phosphorothioate

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-O-methylcytidine-3'-phosphate

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-fluorouridine-3'-phosphate

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-fluoroguanosine-3'-phosphate

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-O-methyluridine-3'-phosphate

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-O-methylguanosine-3'-phosphate

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-methyladenosine-3'-phosphate

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'-O-methyladenosine-3'-phosphorothioate

<220>
<221> modified_base
<222> (23)..(23)
<223> inverted abasic deoxyribonucleotide

<400> 173
nagcugaguu gguuuuauga aan                                               23


<210> 174
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 174
ucaucaauga aggguacguu g                                                 21


<210> 175
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 175
ucaucaauga aggguacguc g                                                 21


<210> 176
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 176
uagugaaaaa cugggaaagg u                                                 21


<210> 177
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 177
uagugaaaaa cugggaaagg g                                                 21


<210> 178
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 178
aaaucuugcu cauguaucca c                                                 21


<210> 179
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 179
uacuugacuu uagggcagau g                                                 21


<210> 180
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 180
uacuugacuu uagggcagac g                                                 21


<210> 181
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 181
uuaguuaggu gaaaaaggug u                                                 21


<210> 182
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 182
ucuugcucau guauccaccu g                                                 21


<210> 183
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 183
acgacuucgu cuuuggaccg a                                                 21


<210> 184
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 184
uaucaaugaa ggguacguug g                                                 21


<210> 185
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 185
uccaaauauc cucgaaggca g                                                 21


<210> 186
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 186
uugaaaaacu gggaaaggug g                                                 21


<210> 187
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 187
uucauaaaac caacucagcu c                                                 21


<210> 188
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 188
ucuugcucau guauccaccu g                                                 21


<210> 189
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 189
agaacguuuu ccccaucaga c                                                 21


<210> 190
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 190
agaacguuuu ccccaucagu u                                                 21


<210> 191
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 191
uacaccagaa cguuuucccc a                                                 21


<210> 192
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 192
ugaaagucag acaccagaac g                                                 21


<210> 193
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 193
uaaggguacg uugucacuca c                                                 21


<210> 194
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 194
uacuuuaggg cagaugucgu g                                                 21


<210> 195
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 195
uguagcaagu ugcaaaucuc g                                                 21


<210> 196
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 196
acgacuucgu cuuuggaccg a                                                 21


<210> 197
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 197
acaagaucug agaggaccug c                                                 21


<210> 198
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 198
ucaaugaagg guacguuguc g                                                 21


<210> 199
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 199
aaucuugcuc auguauccac c                                                 21


<210> 200
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 200
uugucauuuc ccaaccagcu g                                                 21


<210> 201
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 201
uagugaaaaa cugggaaagg c                                                 21


<210> 202
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 202
ucuugcucau guauccaccu u                                                 21


<210> 203
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 203
ucuugcucau guauccaccu c                                                 21


<210> 204
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 204
uuaguuaggu gaaaaaggug c                                                 21


<210> 205
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 205
uuaguuaggu gaaaaaggug u                                                 21


<210> 206
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 206
auccaaauau ccucgaaggc a                                                 21


<210> 207
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 207
ucauguaucc accuuugucu u                                                 21


<210> 208
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 208
ugcaaaucuu gcucauguau c                                                 21


<210> 209
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 209
ucaaguugca aaucuugcuc a                                                 21


<210> 210
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 210
ucaaguugca aaucuugcuc g                                                 21


<210> 211
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 211
uuucauaaaa ccaacucagc u                                                 21


<210> 212
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 212
caacguaccc uucauugaug a                                                 21


<210> 213
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 213
cgacguaccc uucauugaug a                                                 21


<210> 214
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 214
accuuuccca guuuuucacu a                                                 21


<210> 215
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 215
cccuuuccca guuuuucacu a                                                 21


<210> 216
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 216
guggauacau gagcaagauu u                                                 21


<210> 217
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 217
caucugcccu aaagucaagu a                                                 21


<210> 218
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 218
cgucugcccu aaagucaagu a                                                 21


<210> 219
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 219
acaccuuuuu caccuaacua a                                                 21


<210> 220
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 220
cagguggaua caugagcaag a                                                 21


<210> 221
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (16)..(16)
<223> Hypoxanthine

<400> 221
cagguggaua caugancaag a                                                 21


<210> 222
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (20)..(20)
<223> Hypoxanthine

<400> 222
ucgguccaaa gacgaagucn u                                                 21


<210> 223
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 223
ccaacguacc cuucauugau a                                                 21


<210> 224
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(19)
<223> Hypoxanthine

<400> 224
cugccuucga ggauauuung a                                                 21


<210> 225
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 225
ccaccuuucc caguuuuuca a                                                 21


<210> 226
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 226
gagcugaguu gguuuuauga a                                                 21


<210> 227
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 227
gucugauggg gaaaacguuc u                                                 21


<210> 228
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 228
cugaugggga aaacguucuu u                                                 21


<210> 229
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (17)..(17)
<223> Hypoxanthine

<400> 229
uggggaaaac guucugnugu a                                                 21


<210> 230
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 230
cguucuggug ucugacuuuc a                                                 21


<210> 231
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 231
gugagugaca acguacccuu a                                                 21


<210> 232
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 232
cacgacaucu gcccuaaagu a                                                 21


<210> 233
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (16)..(16)
<223> Hypoxanthine

<400> 233
cgagauuugc aacuuncuac a                                                 21


<210> 234
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 234
ucgguccaaa gacgaagucg u                                                 21


<210> 235
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (17)..(17)
<223> Hypoxanthine

<400> 235
ucgguccaaa gacgaanucg u                                                 21


<210> 236
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (20)..(20)
<223> 2-aminoadenine nucleotide

<400> 236
ccaccuuuuu caccuaacua a                                                 21


<210> 237
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (5)..(5)
<223> Hypoxanthine

<400> 237
gcagnuccuc ucagaucuug u                                                 21


<210> 238
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 238
cgacaacgua cccuucauug a                                                 21


<210> 239
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 239
gguggauaca ugagcaagau u                                                 21


<210> 240
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 240
cagcugguug ggaaaugaca a                                                 21


<210> 241
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 241
gccuuuccca guuuuucacu a                                                 21


<210> 242
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (16)..(16)
<223> Hypoxanthine

<400> 242
aagguggaua caugancaag a                                                 21


<210> 243
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (16)..(16)
<223> Hypoxanthine

<400> 243
gagguggaua caugancaag a                                                 21


<210> 244
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-aminoadenine nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> Hypoxanthine

<400> 244
aagguggaua caugancaag a                                                 21


<210> 245
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 245
gcaccuuuuu caccuaacua a                                                 21


<210> 246
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 246
gcaccuuuuu caccuaacua a                                                 21


<210> 247
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-aminoadenine nucleotide

<400> 247
acaccuuuuu caccuaacua a                                                 21


<210> 248
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (20)..(20)
<223> 2-aminoadenine nucleotide

<400> 248
acaccuuuuu caccuaacua a                                                 21


<210> 249
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-aminoadenine nucleotide

<400> 249
acaccuuuuu caccuaacua a                                                 21


<210> 250
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 250
acaccuuuuu caccuaacua a                                                 21


<210> 251
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 251
ugccuucgag gauauuugga u                                                 21


<210> 252
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-aminoadenine nucleotide

<400> 252
aagacaaagg uggauacaug a                                                 21


<210> 253
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> 2-aminoadenine nucleotide

<400> 253
gauacaugag caagauuugc a                                                 21


<210> 254
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 254
ugagcaagau uugcaacuug a                                                 21


<210> 255
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 255
cgagcaagau uugcaacuug a                                                 21


<210> 256
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 256
agcugaguug guuuuaugaa a                                                 21


<210> 257
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 257
caucaaugaa ggguacguu                                                    19


<210> 258
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 258
uuucauaaaa ccaacucag                                                    19


