                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  ENTERIC NITRERGIC NEURONS AND METHODS OF USING THE SAME

<130>  37944.0016P1

<150>  US 62/994,837
<151>  2020-03-25

<150>  US 63/036,492
<151>  2020-06-09

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210>  2
<211>  478
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Ala Ser Leu Arg Pro Phe Phe Ile Leu Ala Leu Leu Ala Leu Val 
1               5                   10                  15      


Ser Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Gln Gly Phe 
            20                  25                  30          


Met Ala Ser Lys Lys Cys Gln Cys Asp Glu Leu Cys Thr Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Val Asp Tyr Met Glu Gln Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Trp Ser Tyr Asp Tyr 
65                  70                  75                  80  


Pro Glu Glu Thr Lys Asn Ser Thr Ser Thr Gly Val Gln Ser Glu Asn 
                85                  90                  95      


Thr Ser Leu His Phe Asn Leu Lys Pro Arg Ala Glu Glu Thr Ile Lys 
            100                 105                 110         


Pro Thr Thr Pro Asp Pro Gln Glu Gln Ser Asn Thr Gln Glu Pro Glu 
        115                 120                 125             


Val Gly Gln Gln Gly Val Ala Pro Arg Pro Asp Thr Thr Asp Glu Gly 
    130                 135                 140                 


Thr Ser Glu Phe Pro Glu Glu Glu Leu Cys Ser Gly Lys Pro Phe Asp 
145                 150                 155                 160 


Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg Gly Glu 
                165                 170                 175     


Tyr Cys Tyr Glu Leu Asp Glu Thr Ala Val Arg Pro Gly Tyr Pro Lys 
            180                 185                 190         


Leu Ile Gln Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala Ala Phe 
        195                 200                 205             


Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly Ser Gln 
    210                 215                 220                 


Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro Arg Asn 
225                 230                 235                 240 


Ile Ser Glu Gly Phe Ser Gly Ile Pro Asp Asn Val Asp Ala Ala Leu 
                245                 250                 255     


Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr Phe Phe 
            260                 265                 270         


Lys Gly Lys Gln Tyr Trp Glu Tyr Glu Phe Gln Gln Gln Pro Ser Gln 
        275                 280                 285             


Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His Phe Ala 
    290                 295                 300                 


Leu Leu Gln Arg Asp Ser Trp Glu Asn Ile Phe Glu Leu Leu Phe Trp 
305                 310                 315                 320 


Gly Arg Ser Ser Asp Gly Ala Lys Gly Pro Gln Phe Ile Ser Arg Asp 
                325                 330                 335     


Trp His Gly Val Pro Gly Lys Val Asp Ala Ala Met Ala Gly Arg Ile 
            340                 345                 350         


Tyr Ile Thr Gly Ser Thr Phe Arg Ser Val Gln Ala Lys Lys Gln Lys 
        355                 360                 365             


Ser Gly Arg Arg Ser Arg Lys Arg Tyr Arg Ser Arg Arg Gly Arg Gly 
    370                 375                 380                 


His Ser Arg Ser Arg Ser Arg Ser Met Ser Ser Arg Arg Pro Ser Arg 
385                 390                 395                 400 


Ser Val Trp Phe Ser Leu Leu Ser Ser Glu Glu Ser Gly Leu Gly Thr 
                405                 410                 415     


Tyr Asn Tyr Asp Tyr Asp Met Asn Trp Arg Ile Pro Ala Thr Cys Glu 
            420                 425                 430         


Pro Ile Gln Ser Val Tyr Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val 
        435                 440                 445             


Asn Leu Arg Thr Arg Arg Val Asp Ser Val Asn Pro Pro Tyr Pro Arg 
    450                 455                 460                 


Ser Ile Ala Gln Tyr Trp Leu Gly Cys Pro Thr Ser Glu Lys 
465                 470                 475             


<210>  3
<211>  478
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Pro Leu Arg Pro Phe Phe Ile Leu Ala Leu Val Ala Trp Val 
1               5                   10                  15      


Ser Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Gln Gly Phe 
            20                  25                  30          


Met Ala Ser Lys Lys Cys Gln Cys Asp Glu Leu Cys Thr Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Ala Asp Tyr Met Glu Gln Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Asp Tyr Trp Ser Tyr Asp Tyr 
65                  70                  75                  80  


Val Glu Glu Pro Lys Asn Asn Thr Asn Thr Gly Val Gln Pro Glu Asn 
                85                  90                  95      


Thr Ser Pro Pro Gly Asp Leu Asn Pro Arg Thr Asp Gly Thr Leu Lys 
            100                 105                 110         


Pro Thr Ala Phe Leu Asp Pro Glu Glu Gln Pro Ser Thr Pro Ala Pro 
        115                 120                 125             


Lys Val Glu Gln Gln Glu Glu Ile Leu Arg Pro Asp Thr Thr Asp Gln 
    130                 135                 140                 


Gly Thr Pro Glu Phe Pro Glu Glu Glu Leu Cys Ser Gly Lys Pro Phe 
145                 150                 155                 160 


Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg Gly 
                165                 170                 175     


Gln Tyr Cys Tyr Glu Leu Asp Glu Thr Ala Val Arg Pro Gly Tyr Pro 
            180                 185                 190         


Lys Leu Ile Gln Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala Ala 
        195                 200                 205             


Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly Ser 
    210                 215                 220                 


Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Gly Tyr Pro Arg 
225                 230                 235                 240 


Asn Ile Ser Glu Gly Phe Ser Gly Ile Pro Asp Asn Val Asp Ala Ala 
                245                 250                 255     


Phe Ala Leu Pro Ala His Arg Tyr Ser Gly Arg Glu Arg Val Tyr Phe 
            260                 265                 270         


Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Glu Phe Gln Gln Gln Pro Ser 
        275                 280                 285             


Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His Phe 
    290                 295                 300                 


Ala Leu Leu Gln Arg Asp Ser Trp Glu Asn Ile Phe Glu Leu Leu Phe 
305                 310                 315                 320 


Trp Gly Arg Ser Ser Asp Gly Ala Arg Glu Pro Gln Phe Ile Ser Arg 
                325                 330                 335     


Asn Trp His Gly Val Pro Gly Lys Val Asp Ala Ala Met Ala Gly Arg 
            340                 345                 350         


Ile Tyr Val Thr Gly Ser Leu Ser His Ser Ala Gln Ala Lys Lys Gln 
        355                 360                 365             


Lys Ser Lys Arg Arg Ser Arg Lys Arg Tyr Arg Ser Arg Arg Gly Arg 
    370                 375                 380                 


Gly His Arg Arg Ser Gln Ser Ser Asn Ser Arg Arg Ser Ser Arg Ser 
385                 390                 395                 400 


Ile Trp Phe Ser Leu Phe Ser Ser Glu Glu Ser Gly Leu Gly Thr Tyr 
                405                 410                 415     


Asn Asn Tyr Asp Tyr Asp Met Asp Trp Leu Val Pro Ala Thr Cys Glu 
            420                 425                 430         


Pro Ile Gln Ser Val Tyr Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val 
        435                 440                 445             


Asn Leu Arg Thr Arg Arg Val Asp Ser Val Asn Pro Pro Tyr Pro Arg 
    450                 455                 460                 


Ser Ile Ala Gln Tyr Trp Leu Gly Cys Pro Thr Ser Glu Lys 
465                 470                 475             


<210>  4
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Leu Arg Thr Ala Lys Lys Arg Gly Leu Gly Gly Gly Gly Lys 
1               5                   10                  15      


Trp Lys Arg Glu Glu Gly Gly Gly Thr Arg Gly Arg Arg Glu Val Arg 
            20                  25                  30          


Pro Ala Cys Phe Leu Gln Ser Gly Gly Arg Gly Asp Pro Gly Asp Val 
        35                  40                  45              


Gly Gly Pro Ala Gly Asn Pro Gly Cys Ser Pro His Pro Arg Ala Ala 
    50                  55                  60                  


Thr Arg Pro Pro Pro Leu Pro Ala His Thr Pro Ala His Thr Pro Glu 
65                  70                  75                  80  


Trp Cys Gly Ala Ala Ser Ala Glu Ala Ala Glu Pro Arg Arg Ala Gly 
                85                  90                  95      


Pro His Leu Cys Ile Pro Ala Pro Gly Leu Thr Lys Thr Pro Ile Leu 
            100                 105                 110         


Glu Lys Val Pro Arg Lys Met Ala Ala Lys Thr Pro Ser Ser Glu Glu 
        115                 120                 125             


Ser Gly Leu Pro Lys Leu Pro Val Pro Pro Leu Gln Gln Thr Leu Ala 
    130                 135                 140                 


Thr Tyr Leu Gln Cys Met Arg His Leu Val Ser Glu Glu Gln Phe Arg 
145                 150                 155                 160 


Lys Ser Gln Ala Ile Val Gln Gln Phe Gly Ala Pro Gly Gly Leu Gly 
                165                 170                 175     


Glu Thr Leu Gln Gln Lys Leu Leu Glu Arg Gln Glu Lys Thr Ala Asn 
            180                 185                 190         


Trp Val Ser Glu Tyr Trp Leu Asn Asp Met Tyr Leu Asn Asn Arg Leu 
        195                 200                 205             


Ala Leu Pro Val Asn Ser Ser Pro Ala Val Ile Phe Ala Arg Gln His 
    210                 215                 220                 


Phe Pro Gly Thr Asp Asp Gln Leu Arg Phe Ala Ala Ser Leu Ile Ser 
225                 230                 235                 240 


Gly Val Leu Ser Tyr Lys Ala Leu Leu Asp Ser His Ser Ile Pro Thr 
                245                 250                 255     


Asp Cys Ala Lys Gly Gln Leu Ser Gly Gln Pro Leu Cys Met Lys Gln 
            260                 265                 270         


Tyr Tyr Gly Leu Phe Ser Ser Tyr Arg Leu Pro Gly His Thr Gln Asp 
        275                 280                 285             


Thr Leu Val Ala Gln Asn Ser Ser Ile Met Pro Glu Pro Glu His Val 
    290                 295                 300                 


Ile Val Ala Cys Cys Asn Gln Phe Phe Val Leu Asp Val Val Ile Asn 
305                 310                 315                 320 


Phe Arg Arg Leu Ser Glu Gly Asp Leu Phe Thr Gln Leu Arg Lys Ile 
                325                 330                 335     


Val Lys Met Ala Ser Asn Glu Asp Glu Arg Leu Pro Pro Ile Gly Leu 
            340                 345                 350         


Leu Thr Ser Asp Gly Arg Ser Glu Trp Ala Glu Ala Arg Thr Val Leu 
        355                 360                 365             


Val Lys Asp Ser Thr Asn Arg Asp Ser Leu Asp Met Ile Glu Arg Cys 
    370                 375                 380                 


Ile Cys Leu Val Cys Leu Asp Ala Pro Gly Gly Val Glu Leu Ser Asp 
385                 390                 395                 400 


Thr His Arg Ala Leu Gln Leu Leu His Gly Gly Gly Tyr Ser Lys Asn 
                405                 410                 415     


Gly Ala Asn Arg Trp Tyr Asp Lys Ser Leu Gln Phe Val Val Gly Arg 
            420                 425                 430         


Asp Gly Thr Cys Gly Val Val Cys Glu His Ser Pro Phe Asp Gly Ile 
        435                 440                 445             


Val Leu Val Gln Cys Thr Glu His Leu Leu Lys His Val Thr Gln Ser 
    450                 455                 460                 


Ser Arg Lys Leu Ile Arg Ala Asp Ser Val Ser Glu Leu Pro Ala Pro 
465                 470                 475                 480 


Arg Arg Leu Arg Trp Lys Cys Ser Pro Glu Ile Gln Gly His Leu Ala 
                485                 490                 495     


Ser Ser Ala Glu Lys Leu Gln Arg Ile Val Lys Asn Leu Asp Phe Ile 
            500                 505                 510         


Val Tyr Lys Phe Asp Asn Tyr Gly Lys Thr Phe Ile Lys Lys Gln Lys 
        515                 520                 525             


Cys Ser Pro Asp Ala Phe Ile Gln Val Ala Leu Gln Leu Ala Phe Tyr 
    530                 535                 540                 


Arg Leu His Arg Arg Leu Val Pro Thr Tyr Glu Ser Ala Ser Ile Arg 
545                 550                 555                 560 


Arg Phe Gln Glu Gly Arg Val Asp Asn Ile Arg Ser Ala Thr Pro Glu 
                565                 570                 575     


Ala Leu Ala Phe Val Arg Ala Val Thr Asp His Lys Ala Ala Val Pro 
            580                 585                 590         


Ala Ser Glu Lys Leu Leu Leu Leu Lys Asp Ala Ile Arg Ala Gln Thr 
        595                 600                 605             


Ala Tyr Thr Val Met Ala Ile Thr Gly Met Ala Ile Asp Asn His Leu 
    610                 615                 620                 


Leu Ala Leu Arg Glu Leu Ala Arg Ala Met Cys Lys Glu Leu Pro Glu 
625                 630                 635                 640 


Met Phe Met Asp Glu Thr Tyr Leu Met Ser Asn Arg Phe Val Leu Ser 
                645                 650                 655     


Thr Ser Gln Val Pro Thr Thr Thr Glu Met Phe Cys Cys Tyr Gly Pro 
            660                 665                 670         


Val Val Pro Asn Gly Tyr Gly Ala Cys Tyr Asn Pro Gln Pro Glu Thr 
        675                 680                 685             


Ile Leu Phe Cys Ile Ser Ser Phe His Ser Cys Lys Glu Thr Ser Ser 
    690                 695                 700                 


Ser Lys Phe Ala Lys Ala Val Glu Glu Ser Leu Ile Asp Met Arg Asp 
705                 710                 715                 720 


Leu Cys Ser Leu Leu Pro Pro Thr Glu Ser Lys Pro Leu Ala Thr Lys 
                725                 730                 735     


Glu Lys Ala Thr Arg Pro Ser Gln Gly His Gln Pro 
            740                 745             


<210>  5
<211>  640
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Pro Ile Leu Glu Lys Ala Pro Gln Lys Met Pro Val Lys Ala Ser 
1               5                   10                  15      


Ser Trp Glu Glu Leu Asp Leu Pro Lys Leu Pro Val Pro Pro Leu Gln 
            20                  25                  30          


Gln Thr Leu Ala Thr Tyr Leu Gln Cys Met Gln His Leu Val Pro Glu 
        35                  40                  45              


Glu Gln Phe Arg Lys Ser Gln Ala Ile Val Lys Arg Phe Gly Ala Pro 
    50                  55                  60                  


Gly Gly Leu Gly Glu Thr Leu Gln Glu Lys Leu Leu Glu Arg Gln Glu 
65                  70                  75                  80  


Lys Thr Ala Asn Trp Val Ser Glu Tyr Trp Leu Asn Asp Met Tyr Leu 
                85                  90                  95      


Asn Asn Arg Leu Ala Leu Pro Val Asn Ser Ser Pro Ala Val Ile Phe 
            100                 105                 110         


Ala Arg Gln His Phe Gln Asp Thr Asn Asp Gln Leu Arg Phe Ala Ala 
        115                 120                 125             


Cys Leu Ile Ser Gly Val Leu Ser Tyr Lys Thr Leu Leu Asp Ser His 
    130                 135                 140                 


Ser Leu Pro Thr Asp Trp Ala Lys Gly Gln Leu Ser Gly Gln Pro Leu 
145                 150                 155                 160 


Cys Met Lys Gln Tyr Tyr Arg Leu Phe Ser Ser Tyr Arg Leu Pro Gly 
                165                 170                 175     


His Thr Gln Asp Thr Leu Val Ala Gln Lys Ser Ser Ile Met Pro Glu 
            180                 185                 190         


Pro Glu His Val Ile Val Ala Cys Cys Asn Gln Phe Phe Val Leu Asp 
        195                 200                 205             


Val Val Ile Asn Phe Arg Arg Leu Ser Glu Gly Asp Leu Phe Thr Gln 
    210                 215                 220                 


Leu Arg Lys Ile Val Lys Met Ala Ser Asn Glu Asp Glu Arg Leu Pro 
225                 230                 235                 240 


Pro Ile Gly Leu Leu Thr Ser Asp Gly Arg Ser Glu Trp Ala Lys Ala 
                245                 250                 255     


Arg Thr Val Leu Leu Lys Asp Ser Thr Asn Arg Asp Ser Leu Asp Met 
            260                 265                 270         


Ile Glu Arg Cys Ile Cys Leu Val Cys Leu Asp Gly Pro Gly Thr Gly 
        275                 280                 285             


Glu Leu Ser Asp Thr His Arg Ala Leu Gln Leu Leu His Gly Gly Gly 
    290                 295                 300                 


Cys Ser Leu Asn Gly Ala Asn Arg Trp Tyr Asp Lys Ser Leu Gln Phe 
305                 310                 315                 320 


Val Val Gly Arg Asp Gly Thr Cys Gly Val Val Cys Glu His Ser Pro 
                325                 330                 335     


Phe Asp Gly Ile Val Leu Val Gln Cys Thr Glu His Leu Leu Lys His 
            340                 345                 350         


Met Met Thr Ser Asn Lys Lys Leu Val Arg Ala Asp Ser Val Ser Glu 
        355                 360                 365             


Leu Pro Ala Pro Arg Arg Leu Arg Leu Lys Cys Ser Pro Glu Thr Gln 
    370                 375                 380                 


Gly His Leu Ala Ser Ser Ala Glu Lys Leu Gln Arg Ile Val Lys Asn 
385                 390                 395                 400 


Leu Asp Phe Ile Val Tyr Lys Phe Asp Asn Tyr Gly Lys Thr Phe Ile 
                405                 410                 415     


Lys Lys Gln Lys Tyr Ser Pro Asp Gly Phe Ile Gln Val Ala Leu Gln 
            420                 425                 430         


Leu Ala Tyr Tyr Arg Leu Tyr Gln Arg Leu Val Pro Thr Tyr Glu Ser 
        435                 440                 445             


Ala Ser Ile Arg Arg Phe Gln Glu Gly Arg Val Asp Asn Ile Arg Ser 
    450                 455                 460                 


Ala Thr Pro Glu Ala Leu Ala Phe Val Gln Ala Met Thr Asp His Lys 
465                 470                 475                 480 


Ala Ala Met Pro Ala Ser Glu Lys Leu Gln Leu Leu Gln Thr Ala Met 
                485                 490                 495     


Gln Ala His Lys Gln Tyr Thr Val Met Ala Ile Thr Gly Met Ala Ile 
            500                 505                 510         


Asp Asn His Leu Leu Ala Leu Arg Glu Leu Ala Arg Asp Leu Cys Lys 
        515                 520                 525             


Glu Pro Pro Glu Met Phe Met Asp Glu Thr Tyr Leu Met Ser Asn Arg 
    530                 535                 540                 


Phe Val Leu Ser Thr Ser Gln Val Pro Thr Thr Met Glu Met Phe Cys 
545                 550                 555                 560 


Cys Tyr Gly Pro Val Val Pro Asn Gly Asn Gly Ala Cys Tyr Asn Pro 
                565                 570                 575     


Gln Pro Glu Ala Ile Thr Phe Cys Ile Ser Ser Phe His Ser Cys Lys 
            580                 585                 590         


Glu Thr Ser Ser Val Glu Phe Ala Glu Ala Val Gly Ala Ser Leu Val 
        595                 600                 605             


Asp Met Arg Asp Leu Cys Ser Ser Arg Gln Pro Ala Asp Ser Lys Pro 
    610                 615                 620                 


Pro Ala Pro Lys Glu Lys Ala Arg Gly Pro Ser Gln Ala Lys Gln Ser 
625                 630                 635                 640 


<210>  6
<211>  641
<212>  PRT
<213>  Mus musculus

<400>  6

Met Pro Ile Leu Glu Lys Val Pro Pro Lys Met Pro Val Gln Ala Ser 
1               5                   10                  15      


Ser Cys Glu Glu Val Leu Asp Leu Pro Lys Leu Pro Val Pro Pro Leu 
            20                  25                  30          


Gln Gln Thr Leu Ala Thr Tyr Leu Gln Cys Met Gln His Leu Val Pro 
        35                  40                  45              


Glu Glu Gln Phe Arg Lys Ser Gln Ala Ile Val Lys Arg Phe Gly Ala 
    50                  55                  60                  


Pro Gly Gly Leu Gly Glu Thr Leu Gln Glu Lys Leu Leu Glu Arg Gln 
65                  70                  75                  80  


Glu Lys Thr Ala Asn Trp Val Ser Glu Tyr Trp Leu Asn Asp Met Tyr 
                85                  90                  95      


Leu Asn Asn Arg Leu Ala Leu Pro Val Asn Ser Ser Pro Ala Val Ile 
            100                 105                 110         


Phe Ala Arg Gln His Phe Gln Asp Thr Asn Asp Gln Leu Arg Phe Ala 
        115                 120                 125             


Ala Ser Leu Ile Ser Gly Val Leu Ser Tyr Lys Ala Leu Leu Asp Ser 
    130                 135                 140                 


Gln Ser Ile Pro Thr Asp Trp Ala Lys Gly Gln Leu Ser Gly Gln Pro 
145                 150                 155                 160 


Leu Cys Met Lys Gln Tyr Tyr Arg Leu Phe Ser Ser Tyr Arg Leu Pro 
                165                 170                 175     


Gly His Thr Gln Asp Thr Leu Val Ala Gln Lys Ser Ser Ile Met Pro 
            180                 185                 190         


Glu Pro Glu His Val Ile Val Ala Cys Cys Asn Gln Phe Phe Val Leu 
        195                 200                 205             


Asp Val Val Ile Asn Phe Arg Arg Leu Ser Glu Gly Asp Leu Phe Thr 
    210                 215                 220                 


Gln Leu Arg Lys Ile Val Lys Met Ala Ser Asn Glu Asp Glu Arg Leu 
225                 230                 235                 240 


Pro Pro Ile Gly Leu Leu Thr Ser Asp Gly Arg Ser Glu Trp Ala Lys 
                245                 250                 255     


Ala Arg Thr Val Leu Leu Lys Asp Ser Thr Asn Arg Asp Ser Leu Asp 
            260                 265                 270         


Met Ile Glu Arg Cys Ile Cys Leu Val Cys Leu Asp Gly Pro Gly Thr 
        275                 280                 285             


Gly Asp Leu Ser Asp Thr His Arg Ala Leu Gln Leu Leu His Gly Gly 
    290                 295                 300                 


Gly Cys Ser Leu Asn Gly Ala Asn Arg Trp Tyr Asp Lys Ser Leu Gln 
305                 310                 315                 320 


Phe Val Val Gly Arg Asp Gly Thr Cys Gly Val Val Cys Glu His Ser 
                325                 330                 335     


Pro Phe Asp Gly Ile Val Leu Val Gln Cys Thr Glu His Leu Leu Lys 
            340                 345                 350         


His Met Met Thr Gly Asn Lys Lys Leu Val Arg Val Asp Ser Val Ser 
        355                 360                 365             


Glu Leu Pro Ala Pro Arg Arg Leu Arg Trp Lys Cys Ser Pro Glu Thr 
    370                 375                 380                 


Gln Gly His Leu Ala Ser Ser Ala Glu Lys Leu Gln Arg Ile Val Lys 
385                 390                 395                 400 


Asn Leu Asp Phe Ile Val Tyr Lys Phe Asp Asn Tyr Gly Lys Thr Phe 
                405                 410                 415     


Ile Lys Lys Gln Lys Cys Ser Pro Asp Gly Phe Ile Gln Val Ala Leu 
            420                 425                 430         


Gln Leu Ala Tyr Tyr Arg Leu Tyr Gln Arg Leu Val Pro Thr Tyr Glu 
        435                 440                 445             


Ser Ala Ser Ile Arg Arg Phe Gln Glu Gly Arg Val Asp Asn Ile Arg 
    450                 455                 460                 


Ser Ala Thr Pro Glu Ala Leu Ala Phe Val Gln Ala Met Thr Asp His 
465                 470                 475                 480 


Lys Ala Ala Val Leu Ala Ser Glu Lys Leu Gln Leu Leu Gln Arg Ala 
                485                 490                 495     


Ile Gln Ala Gln Thr Glu Tyr Thr Val Met Ala Ile Thr Gly Met Ala 
            500                 505                 510         


Ile Asp Asn His Leu Leu Ala Leu Arg Glu Leu Ala Arg Asp Leu Cys 
        515                 520                 525             


Lys Glu Pro Pro Glu Met Phe Met Asp Glu Thr Tyr Leu Met Ser Asn 
    530                 535                 540                 


Arg Phe Ile Leu Ser Thr Ser Gln Val Pro Thr Thr Met Glu Met Phe 
545                 550                 555                 560 


Cys Cys Tyr Gly Pro Val Val Pro Asn Gly Tyr Gly Ala Cys Tyr Asn 
                565                 570                 575     


Pro His Ala Glu Ala Ile Thr Phe Cys Ile Ser Ser Phe His Gly Cys 
            580                 585                 590         


Lys Glu Thr Ser Ser Val Glu Phe Ala Glu Ala Val Gly Ala Ser Leu 
        595                 600                 605             


Val Asp Met Arg Asp Leu Cys Ser Ser Arg Gln Pro Ala Asp Ser Lys 
    610                 615                 620                 


Pro Pro Thr Ala Lys Glu Arg Ala Arg Gly Pro Ser Gln Ala Lys Gln 
625                 630                 635                 640 


Ser 
    


<210>  7
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Val Leu Ser Pro Gly Gln Gly Asn Asn Thr Thr Ser Pro Pro 
1               5                   10                  15      


Ala Pro Phe Glu Thr Gly Gly Asn Thr Thr Gly Ile Ser Asp Val Thr 
            20                  25                  30          


Val Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 
        35                  40                  45              


Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 
    50                  55                  60                  


Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 
65                  70                  75                  80  


Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 
                85                  90                  95      


Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 
            100                 105                 110         


Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 
        115                 120                 125             


Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 
    130                 135                 140                 


Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 
145                 150                 155                 160 


Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 
                165                 170                 175     


Thr Pro Glu Asp Arg Ser Asp Pro Asp Ala Cys Thr Ile Ser Lys Asp 
            180                 185                 190         


His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 
        195                 200                 205             


Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 
    210                 215                 220                 


Arg Ile Arg Lys Thr Val Lys Lys Val Glu Lys Thr Gly Ala Asp Thr 
225                 230                 235                 240 


Arg His Gly Ala Ser Pro Ala Pro Gln Pro Lys Lys Ser Val Asn Gly 
                245                 250                 255     


Glu Ser Gly Ser Arg Asn Trp Arg Leu Gly Val Glu Ser Lys Ala Gly 
            260                 265                 270         


Gly Ala Leu Cys Ala Asn Gly Ala Val Arg Gln Gly Asp Asp Gly Ala 
        275                 280                 285             


Ala Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Glu His 
    290                 295                 300                 


Leu Pro Leu Pro Ser Glu Ala Gly Pro Thr Pro Cys Ala Pro Ala Ser 
305                 310                 315                 320 


Phe Glu Arg Lys Asn Glu Arg Asn Ala Glu Ala Lys Arg Lys Met Ala 
                325                 330                 335     


Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 
            340                 345                 350         


Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 
        355                 360                 365             


Pro Phe Cys Glu Ser Ser Cys His Met Pro Thr Leu Leu Gly Ala Ile 
    370                 375                 380                 


Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 
                405                 410                 415     


Cys Lys Phe Cys Arg Gln 
            420         


<210>  8
<211>  422
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Asp Val Phe Ser Phe Gly Gln Gly Asn Asn Thr Thr Ala Ser Gln 
1               5                   10                  15      


Glu Pro Phe Gly Thr Gly Gly Asn Val Thr Ser Ile Ser Asp Val Thr 
            20                  25                  30          


Phe Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 
        35                  40                  45              


Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 
    50                  55                  60                  


Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 
65                  70                  75                  80  


Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 
                85                  90                  95      


Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 
            100                 105                 110         


Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 
        115                 120                 125             


Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 
    130                 135                 140                 


Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 
145                 150                 155                 160 


Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 
                165                 170                 175     


Thr Pro Glu Asp Arg Ser Asp Pro Asp Ala Cys Thr Ile Ser Lys Asp 
            180                 185                 190         


His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 
        195                 200                 205             


Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 
    210                 215                 220                 


Arg Ile Arg Lys Thr Val Arg Lys Val Glu Lys Lys Gly Ala Gly Thr 
225                 230                 235                 240 


Ser Leu Gly Thr Ser Ser Ala Pro Pro Pro Lys Lys Ser Leu Asn Gly 
                245                 250                 255     


Gln Pro Gly Ser Gly Asp Trp Arg Arg Cys Ala Glu Asn Arg Ala Val 
            260                 265                 270         


Gly Thr Pro Cys Thr Asn Gly Ala Val Arg Gln Gly Asp Asp Glu Ala 
        275                 280                 285             


Thr Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Glu His 
    290                 295                 300                 


Leu Pro Leu Pro Ser Glu Ser Gly Ser Asn Ser Tyr Ala Pro Ala Cys 
305                 310                 315                 320 


Leu Glu Arg Lys Asn Glu Arg Asn Ala Glu Ala Lys Arg Lys Met Ala 
                325                 330                 335     


Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 
            340                 345                 350         


Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 
        355                 360                 365             


Pro Phe Cys Glu Ser Ser Cys His Met Pro Ala Leu Leu Gly Ala Ile 
    370                 375                 380                 


Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 
                405                 410                 415     


Cys Lys Phe Cys Arg Arg 
            420         


<210>  9
<211>  421
<212>  PRT
<213>  Mus musculus

<400>  9

Met Asp Met Phe Ser Leu Gly Gln Gly Asn Asn Thr Thr Thr Ser Leu 
1               5                   10                  15      


Glu Pro Phe Gly Thr Gly Gly Asn Asp Thr Gly Leu Ser Asn Val Thr 
            20                  25                  30          


Phe Ser Tyr Gln Val Ile Thr Ser Leu Leu Leu Gly Thr Leu Ile Phe 
        35                  40                  45              


Cys Ala Val Leu Gly Asn Ala Cys Val Val Ala Ala Ile Ala Leu Glu 
    50                  55                  60                  


Arg Ser Leu Gln Asn Val Ala Asn Tyr Leu Ile Gly Ser Leu Ala Val 
65                  70                  75                  80  


Thr Asp Leu Met Val Ser Val Leu Val Leu Pro Met Ala Ala Leu Tyr 
                85                  90                  95      


Gln Val Leu Asn Lys Trp Thr Leu Gly Gln Val Thr Cys Asp Leu Phe 
            100                 105                 110         


Ile Ala Leu Asp Val Leu Cys Cys Thr Ser Ser Ile Leu His Leu Cys 
        115                 120                 125             


Ala Ile Ala Leu Asp Arg Tyr Trp Ala Ile Thr Asp Pro Ile Asp Tyr 
    130                 135                 140                 


Val Asn Lys Arg Thr Pro Arg Arg Ala Ala Ala Leu Ile Ser Leu Thr 
145                 150                 155                 160 


Trp Leu Ile Gly Phe Leu Ile Ser Ile Pro Pro Met Leu Gly Trp Arg 
                165                 170                 175     


Thr Pro Glu Asp Arg Ser Asn Pro Asn Glu Cys Thr Ile Ser Lys Asp 
            180                 185                 190         


His Gly Tyr Thr Ile Tyr Ser Thr Phe Gly Ala Phe Tyr Ile Pro Leu 
        195                 200                 205             


Leu Leu Met Leu Val Leu Tyr Gly Arg Ile Phe Arg Ala Ala Arg Phe 
    210                 215                 220                 


Arg Ile Arg Lys Thr Val Lys Lys Val Glu Lys Lys Gly Ala Gly Thr 
225                 230                 235                 240 


Ser Phe Gly Thr Ser Ser Ala Pro Pro Pro Lys Lys Ser Leu Asn Gly 
                245                 250                 255     


Gln Pro Gly Ser Gly Asp Cys Arg Arg Ser Ala Glu Asn Arg Ala Val 
            260                 265                 270         


Gly Thr Pro Cys Ala Asn Gly Ala Val Arg Gln Gly Glu Asp Asp Ala 
        275                 280                 285             


Thr Leu Glu Val Ile Glu Val His Arg Val Gly Asn Ser Lys Gly His 
    290                 295                 300                 


Leu Pro Leu Pro Ser Glu Ser Gly Ala Thr Ser Tyr Val Pro Ala Cys 
305                 310                 315                 320 


Leu Glu Arg Lys Asn Glu Arg Thr Ala Glu Ala Lys Arg Lys Met Ala 
                325                 330                 335     


Leu Ala Arg Glu Arg Lys Thr Val Lys Thr Leu Gly Ile Ile Met Gly 
            340                 345                 350         


Thr Phe Ile Leu Cys Trp Leu Pro Phe Phe Ile Val Ala Leu Val Leu 
        355                 360                 365             


Pro Phe Cys Glu Ser Ser Cys His Met Pro Glu Leu Leu Gly Ala Ile 
    370                 375                 380                 


Ile Asn Trp Leu Gly Tyr Ser Asn Ser Leu Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Ala Tyr Phe Asn Lys Asp Phe Gln Asn Ala Phe Lys Lys Ile Ile Lys 
                405                 410                 415     


Cys Lys Phe Cys Arg 
            420     


<210>  10
<211>  1434
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Asp His Met Phe Gly Val Gln Gln Ile Gln Pro Asn Val Ile 
1               5                   10                  15      


Ser Val Arg Leu Phe Lys Arg Lys Val Gly Gly Leu Gly Phe Leu Val 
            20                  25                  30          


Lys Glu Arg Val Ser Lys Pro Pro Val Ile Ile Ser Asp Leu Ile Arg 
        35                  40                  45              


Gly Gly Ala Ala Glu Gln Ser Gly Leu Ile Gln Ala Gly Asp Ile Ile 
    50                  55                  60                  


Leu Ala Val Asn Gly Arg Pro Leu Val Asp Leu Ser Tyr Asp Ser Ala 
65                  70                  75                  80  


Leu Glu Val Leu Arg Gly Ile Ala Ser Glu Thr His Val Val Leu Ile 
                85                  90                  95      


Leu Arg Gly Pro Glu Gly Phe Thr Thr His Leu Glu Thr Thr Phe Thr 
            100                 105                 110         


Gly Asp Gly Thr Pro Lys Thr Ile Arg Val Thr Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Lys Ala Val Asp Leu Ser His Gln Pro Pro Ala Gly Lys Glu 
    130                 135                 140                 


Gln Pro Leu Ala Val Asp Gly Ala Ser Gly Pro Gly Asn Gly Pro Gln 
145                 150                 155                 160 


His Ala Tyr Asp Asp Gly Gln Glu Ala Gly Ser Leu Pro His Ala Asn 
                165                 170                 175     


Gly Leu Ala Pro Arg Pro Pro Gly Gln Asp Pro Ala Lys Lys Ala Thr 
            180                 185                 190         


Arg Val Ser Leu Gln Gly Arg Gly Glu Asn Asn Glu Leu Leu Lys Glu 
        195                 200                 205             


Ile Glu Pro Val Leu Ser Leu Leu Thr Ser Gly Ser Arg Gly Val Lys 
    210                 215                 220                 


Gly Gly Ala Pro Ala Lys Ala Glu Met Lys Asp Met Gly Ile Gln Val 
225                 230                 235                 240 


Asp Arg Asp Leu Asp Gly Lys Ser His Lys Pro Leu Pro Leu Gly Val 
                245                 250                 255     


Glu Asn Asp Arg Val Phe Asn Asp Leu Trp Gly Lys Gly Asn Val Pro 
            260                 265                 270         


Val Val Leu Asn Asn Pro Tyr Ser Glu Lys Glu Gln Pro Pro Thr Ser 
        275                 280                 285             


Gly Lys Gln Ser Pro Thr Lys Asn Gly Ser Pro Ser Lys Cys Pro Arg 
    290                 295                 300                 


Phe Leu Lys Val Lys Asn Trp Glu Thr Glu Val Val Leu Thr Asp Thr 
305                 310                 315                 320 


Leu His Leu Lys Ser Thr Leu Glu Thr Gly Cys Thr Glu Tyr Ile Cys 
                325                 330                 335     


Met Gly Ser Ile Met His Pro Ser Gln His Ala Arg Arg Pro Glu Asp 
            340                 345                 350         


Val Arg Thr Lys Gly Gln Leu Phe Pro Leu Ala Lys Glu Phe Ile Asp 
        355                 360                 365             


Gln Tyr Tyr Ser Ser Ile Lys Arg Phe Gly Ser Lys Ala His Met Glu 
    370                 375                 380                 


Arg Leu Glu Glu Val Asn Lys Glu Ile Asp Thr Thr Ser Thr Tyr Gln 
385                 390                 395                 400 


Leu Lys Asp Thr Glu Leu Ile Tyr Gly Ala Lys His Ala Trp Arg Asn 
                405                 410                 415     


Ala Ser Arg Cys Val Gly Arg Ile Gln Trp Ser Lys Leu Gln Val Phe 
            420                 425                 430         


Asp Ala Arg Asp Cys Thr Thr Ala His Gly Met Phe Asn Tyr Ile Cys 
        435                 440                 445             


Asn His Val Lys Tyr Ala Thr Asn Lys Gly Asn Leu Arg Ser Ala Ile 
    450                 455                 460                 


Thr Ile Phe Pro Gln Arg Thr Asp Gly Lys His Asp Phe Arg Val Trp 
465                 470                 475                 480 


Asn Ser Gln Leu Ile Arg Tyr Ala Gly Tyr Lys Gln Pro Asp Gly Ser 
                485                 490                 495     


Thr Leu Gly Asp Pro Ala Asn Val Gln Phe Thr Glu Ile Cys Ile Gln 
            500                 505                 510         


Gln Gly Trp Lys Pro Pro Arg Gly Arg Phe Asp Val Leu Pro Leu Leu 
        515                 520                 525             


Leu Gln Ala Asn Gly Asn Asp Pro Glu Leu Phe Gln Ile Pro Pro Glu 
    530                 535                 540                 


Leu Val Leu Glu Val Pro Ile Arg His Pro Lys Phe Glu Trp Phe Lys 
545                 550                 555                 560 


Asp Leu Gly Leu Lys Trp Tyr Gly Leu Pro Ala Val Ser Asn Met Leu 
                565                 570                 575     


Leu Glu Ile Gly Gly Leu Glu Phe Ser Ala Cys Pro Phe Ser Gly Trp 
            580                 585                 590         


Tyr Met Gly Thr Glu Ile Gly Val Arg Asp Tyr Cys Asp Asn Ser Arg 
        595                 600                 605             


Tyr Asn Ile Leu Glu Glu Val Ala Lys Lys Met Asn Leu Asp Met Arg 
    610                 615                 620                 


Lys Thr Ser Ser Leu Trp Lys Asp Gln Ala Leu Val Glu Ile Asn Ile 
625                 630                 635                 640 


Ala Val Leu Tyr Ser Phe Gln Ser Asp Lys Val Thr Ile Val Asp His 
                645                 650                 655     


His Ser Ala Thr Glu Ser Phe Ile Lys His Met Glu Asn Glu Tyr Arg 
            660                 665                 670         


Cys Arg Gly Gly Cys Pro Ala Asp Trp Val Trp Ile Val Pro Pro Met 
        675                 680                 685             


Ser Gly Ser Ile Thr Pro Val Phe His Gln Glu Met Leu Asn Tyr Arg 
    690                 695                 700                 


Leu Thr Pro Ser Phe Glu Tyr Gln Pro Asp Pro Trp Asn Thr His Val 
705                 710                 715                 720 


Trp Lys Gly Thr Asn Gly Thr Pro Thr Lys Arg Arg Ala Ile Gly Phe 
                725                 730                 735     


Lys Lys Leu Ala Glu Ala Val Lys Phe Ser Ala Lys Leu Met Gly Gln 
            740                 745                 750         


Ala Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Ala Thr Glu Thr 
        755                 760                 765             


Gly Lys Ser Gln Ala Tyr Ala Lys Thr Leu Cys Glu Ile Phe Lys His 
    770                 775                 780                 


Ala Phe Asp Ala Lys Val Met Ser Met Glu Glu Tyr Asp Ile Val His 
785                 790                 795                 800 


Leu Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn 
                805                 810                 815     


Gly Asp Pro Pro Glu Asn Gly Glu Lys Phe Gly Cys Ala Leu Met Glu 
            820                 825                 830         


Met Arg His Pro Asn Ser Val Gln Glu Glu Arg Lys Ser Tyr Lys Val 
        835                 840                 845             


Arg Phe Asn Ser Val Ser Ser Tyr Ser Asp Ser Gln Lys Ser Ser Gly 
    850                 855                 860                 


Asp Gly Pro Asp Leu Arg Asp Asn Phe Glu Ser Ala Gly Pro Leu Ala 
865                 870                 875                 880 


Asn Val Arg Phe Ser Val Phe Gly Leu Gly Ser Arg Ala Tyr Pro His 
                885                 890                 895     


Phe Cys Ala Phe Gly His Ala Val Asp Thr Leu Leu Glu Glu Leu Gly 
            900                 905                 910         


Gly Glu Arg Ile Leu Lys Met Arg Glu Gly Asp Glu Leu Cys Gly Gln 
        915                 920                 925             


Glu Glu Ala Phe Arg Thr Trp Ala Lys Lys Val Phe Lys Ala Ala Cys 
    930                 935                 940                 


Asp Val Phe Cys Val Gly Asp Asp Val Asn Ile Glu Lys Ala Asn Asn 
945                 950                 955                 960 


Ser Leu Ile Ser Asn Asp Arg Ser Trp Lys Arg Asn Lys Phe Arg Leu 
                965                 970                 975     


Thr Phe Val Ala Glu Ala Pro Glu Leu Thr Gln Gly Leu Ser Asn Val 
            980                 985                 990         


His Lys Lys Arg Val Ser Ala Ala  Arg Leu Leu Ser Arg  Gln Asn Leu 
        995                 1000                 1005             


Gln Ser  Pro Lys Ser Ser Arg  Ser Thr Ile Phe Val  Arg Leu His 
    1010                 1015                 1020             


Thr Asn  Gly Ser Gln Glu Leu  Gln Tyr Gln Pro Gly  Asp His Leu 
    1025                 1030                 1035             


Gly Val  Phe Pro Gly Asn His  Glu Asp Leu Val Asn  Ala Leu Ile 
    1040                 1045                 1050             


Glu Arg  Leu Glu Asp Ala Pro  Pro Val Asn Gln Met  Val Lys Val 
    1055                 1060                 1065             


Glu Leu  Leu Glu Glu Arg Asn  Thr Ala Leu Gly Val  Ile Ser Asn 
    1070                 1075                 1080             


Trp Thr  Asp Glu Leu Arg Leu  Pro Pro Cys Thr Ile  Phe Gln Ala 
    1085                 1090                 1095             


Phe Lys  Tyr Tyr Leu Asp Ile  Thr Thr Pro Pro Thr  Pro Leu Gln 
    1100                 1105                 1110             


Leu Gln  Gln Phe Ala Ser Leu  Ala Thr Ser Glu Lys  Glu Lys Gln 
    1115                 1120                 1125             


Arg Leu  Leu Val Leu Ser Lys  Gly Leu Gln Glu Tyr  Glu Glu Trp 
    1130                 1135                 1140             


Lys Trp  Gly Lys Asn Pro Thr  Ile Val Glu Val Leu  Glu Glu Phe 
    1145                 1150                 1155             


Pro Ser  Ile Gln Met Pro Ala  Thr Leu Leu Leu Thr  Gln Leu Ser 
    1160                 1165                 1170             


Leu Leu  Gln Pro Arg Tyr Tyr  Ser Ile Ser Ser Ser  Pro Asp Met 
    1175                 1180                 1185             


Tyr Pro  Asp Glu Val His Leu  Thr Val Ala Ile Val  Ser Tyr Arg 
    1190                 1195                 1200             


Thr Arg  Asp Gly Glu Gly Pro  Ile His His Gly Val  Cys Ser Ser 
    1205                 1210                 1215             


Trp Leu  Asn Arg Ile Gln Ala  Asp Glu Leu Val Pro  Cys Phe Val 
    1220                 1225                 1230             


Arg Gly  Ala Pro Ser Phe His  Leu Pro Arg Asn Pro  Gln Val Pro 
    1235                 1240                 1245             


Cys Ile  Leu Val Gly Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Ser 
    1250                 1255                 1260             


Phe Trp  Gln Gln Arg Gln Phe  Asp Ile Gln His Lys  Gly Met Asn 
    1265                 1270                 1275             


Pro Cys  Pro Met Val Leu Val  Phe Gly Cys Arg Gln  Ser Lys Ile 
    1280                 1285                 1290             


Asp His  Ile Tyr Arg Glu Glu  Thr Leu Gln Ala Lys  Asn Lys Gly 
    1295                 1300                 1305             


Val Phe  Arg Glu Leu Tyr Thr  Ala Tyr Ser Arg Glu  Pro Asp Lys 
    1310                 1315                 1320             


Pro Lys  Lys Tyr Val Gln Asp  Ile Leu Gln Glu Gln  Leu Ala Glu 
    1325                 1330                 1335             


Ser Val  Tyr Arg Ala Leu Lys  Glu Gln Gly Gly His  Ile Tyr Val 
    1340                 1345                 1350             


Cys Gly  Asp Val Thr Met Ala  Ala Asp Val Leu Lys  Ala Ile Gln 
    1355                 1360                 1365             


Arg Ile  Met Thr Gln Gln Gly  Lys Leu Ser Ala Glu  Asp Ala Gly 
    1370                 1375                 1380             


Val Phe  Ile Ser Arg Met Arg  Asp Asp Asn Arg Tyr  His Glu Asp 
    1385                 1390                 1395             


Ile Phe  Gly Val Thr Leu Arg  Thr Tyr Glu Val Thr  Asn Arg Leu 
    1400                 1405                 1410             


Arg Ser  Glu Ser Ile Ala Phe  Ile Glu Glu Ser Lys  Lys Asp Thr 
    1415                 1420                 1425             


Asp Glu  Val Phe Ser Ser 
    1430                 


<210>  11
<211>  1429
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Glu Glu Asn Thr Phe Gly Val Gln Gln Ile Gln Pro Asn Val Ile 
1               5                   10                  15      


Ser Val Arg Leu Phe Lys Arg Lys Val Gly Gly Leu Gly Phe Leu Val 
            20                  25                  30          


Lys Glu Arg Val Ser Lys Pro Pro Val Ile Ile Ser Asp Leu Ile Arg 
        35                  40                  45              


Gly Gly Ala Ala Glu Gln Ser Gly Leu Ile Gln Ala Gly Asp Ile Ile 
    50                  55                  60                  


Leu Ala Val Asn Asp Arg Pro Leu Val Asp Leu Ser Tyr Asp Ser Ala 
65                  70                  75                  80  


Leu Glu Val Leu Arg Gly Ile Ala Ser Glu Thr His Val Val Leu Ile 
                85                  90                  95      


Leu Arg Gly Pro Glu Gly Phe Thr Thr His Leu Glu Thr Thr Phe Thr 
            100                 105                 110         


Gly Asp Gly Thr Pro Lys Thr Ile Arg Val Thr Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Lys Ala Val Asp Leu Ser His Gln Pro Ser Ala Ser Lys Asp 
    130                 135                 140                 


Gln Ser Leu Ala Val Asp Arg Val Thr Gly Leu Gly Asn Gly Pro Gln 
145                 150                 155                 160 


His Ala Gln Gly His Gly Gln Gly Ala Gly Ser Val Ser Gln Ala Asn 
                165                 170                 175     


Gly Val Ala Ile Asp Pro Thr Met Lys Ser Thr Lys Ala Asn Leu Gln 
            180                 185                 190         


Asp Ile Gly Glu His Asp Glu Leu Leu Lys Glu Ile Glu Pro Val Leu 
        195                 200                 205             


Ser Ile Leu Asn Ser Gly Ser Lys Ala Thr Asn Arg Gly Gly Pro Ala 
    210                 215                 220                 


Lys Ala Glu Met Lys Asp Thr Gly Ile Gln Val Asp Arg Asp Leu Asp 
225                 230                 235                 240 


Gly Lys Ser His Lys Ala Pro Pro Leu Gly Gly Asp Asn Asp Arg Val 
                245                 250                 255     


Phe Asn Asp Leu Trp Gly Lys Asp Asn Val Pro Val Ile Leu Asn Asn 
            260                 265                 270         


Pro Tyr Ser Glu Lys Glu Gln Ser Pro Thr Ser Gly Lys Gln Ser Pro 
        275                 280                 285             


Thr Lys Asn Gly Ser Pro Ser Arg Cys Pro Arg Phe Leu Lys Val Lys 
    290                 295                 300                 


Asn Trp Glu Thr Asp Val Val Leu Thr Asp Thr Leu His Leu Lys Ser 
305                 310                 315                 320 


Thr Leu Glu Thr Gly Cys Thr Glu His Ile Cys Met Gly Ser Ile Met 
                325                 330                 335     


Leu Pro Ser Gln His Thr Arg Lys Pro Glu Asp Val Arg Thr Lys Asp 
            340                 345                 350         


Gln Leu Phe Pro Leu Ala Lys Glu Phe Leu Asp Gln Tyr Tyr Ser Ser 
        355                 360                 365             


Ile Lys Arg Phe Gly Ser Lys Ala His Met Asp Arg Leu Glu Glu Val 
    370                 375                 380                 


Asn Lys Glu Ile Glu Ser Thr Ser Thr Tyr Gln Leu Lys Asp Thr Glu 
385                 390                 395                 400 


Leu Ile Tyr Gly Ala Lys His Ala Trp Arg Asn Ala Ser Arg Cys Val 
                405                 410                 415     


Gly Arg Ile Gln Trp Ser Lys Leu Gln Val Phe Asp Ala Arg Asp Cys 
            420                 425                 430         


Thr Thr Ala His Gly Met Phe Asn Tyr Ile Cys Asn His Val Lys Tyr 
        435                 440                 445             


Ala Thr Asn Lys Gly Asn Leu Arg Ser Ala Ile Thr Ile Phe Pro Gln 
    450                 455                 460                 


Arg Thr Asp Gly Lys His Asp Phe Arg Val Trp Asn Ser Gln Leu Ile 
465                 470                 475                 480 


Arg Tyr Ala Gly Tyr Lys Gln Pro Asp Gly Ser Thr Leu Gly Asp Pro 
                485                 490                 495     


Ala Asn Val Gln Phe Thr Glu Ile Cys Ile Gln Gln Gly Trp Lys Ala 
            500                 505                 510         


Pro Arg Gly Arg Phe Asp Val Leu Pro Leu Leu Leu Gln Ala Asn Gly 
        515                 520                 525             


Asn Asp Pro Glu Leu Phe Gln Ile Pro Pro Glu Leu Val Leu Glu Val 
    530                 535                 540                 


Pro Ile Arg His Pro Lys Phe Asp Trp Phe Lys Asp Leu Gly Leu Lys 
545                 550                 555                 560 


Trp Tyr Gly Leu Pro Ala Val Ser Asn Met Leu Leu Glu Ile Gly Gly 
                565                 570                 575     


Leu Glu Phe Ser Ala Cys Pro Phe Ser Gly Trp Tyr Met Gly Thr Glu 
            580                 585                 590         


Ile Gly Val Arg Asp Tyr Cys Asp Asn Ser Arg Tyr Asn Ile Leu Glu 
        595                 600                 605             


Glu Val Ala Lys Lys Met Asp Leu Asp Met Arg Lys Thr Ser Ser Leu 
    610                 615                 620                 


Trp Lys Asp Gln Ala Leu Val Glu Ile Asn Ile Ala Val Leu Tyr Ser 
625                 630                 635                 640 


Phe Gln Ser Asp Lys Val Thr Ile Val Asp His His Ser Ala Thr Glu 
                645                 650                 655     


Ser Phe Ile Lys His Met Glu Asn Glu Tyr Arg Cys Arg Gly Gly Cys 
            660                 665                 670         


Pro Ala Asp Trp Val Trp Ile Val Pro Pro Met Ser Gly Ser Ile Thr 
        675                 680                 685             


Pro Val Phe His Gln Glu Met Leu Asn Tyr Arg Leu Thr Pro Ser Phe 
    690                 695                 700                 


Glu Tyr Gln Pro Asp Pro Trp Asn Thr His Val Trp Lys Gly Thr Asn 
705                 710                 715                 720 


Gly Thr Pro Thr Lys Arg Arg Ala Ile Gly Phe Lys Lys Leu Ala Glu 
                725                 730                 735     


Ala Val Lys Phe Ser Ala Lys Leu Met Gly Gln Ala Met Ala Lys Arg 
            740                 745                 750         


Val Lys Ala Thr Ile Leu Tyr Ala Thr Glu Thr Gly Lys Ser Gln Ala 
        755                 760                 765             


Tyr Ala Lys Thr Leu Cys Glu Ile Phe Lys His Ala Phe Asp Ala Lys 
    770                 775                 780                 


Ala Met Ser Met Glu Glu Tyr Asp Ile Val His Leu Glu His Glu Ala 
785                 790                 795                 800 


Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn Gly Asp Pro Pro Glu 
                805                 810                 815     


Asn Gly Glu Lys Phe Gly Cys Ala Leu Met Glu Met Arg His Pro Asn 
            820                 825                 830         


Ser Val Gln Glu Glu Arg Lys Ser Tyr Lys Val Arg Phe Asn Ser Val 
        835                 840                 845             


Ser Ser Tyr Ser Asp Ser Arg Lys Ser Ser Gly Asp Gly Pro Asp Leu 
    850                 855                 860                 


Arg Asp Asn Phe Glu Ser Thr Gly Pro Leu Ala Asn Val Arg Phe Ser 
865                 870                 875                 880 


Val Phe Gly Leu Gly Ser Arg Ala Tyr Pro His Phe Cys Ala Phe Gly 
                885                 890                 895     


His Ala Val Asp Thr Leu Leu Glu Glu Leu Gly Gly Glu Arg Ile Leu 
            900                 905                 910         


Lys Met Arg Glu Gly Asp Glu Leu Cys Gly Gln Glu Glu Ala Phe Arg 
        915                 920                 925             


Thr Trp Ala Lys Lys Val Phe Lys Ala Ala Cys Asp Val Phe Cys Val 
    930                 935                 940                 


Gly Asp Asp Val Asn Ile Glu Lys Pro Asn Asn Ser Leu Ile Ser Asn 
945                 950                 955                 960 


Asp Arg Ser Trp Lys Arg Asn Lys Phe Arg Leu Thr Tyr Val Ala Glu 
                965                 970                 975     


Ala Pro Asp Leu Thr Gln Gly Leu Ser Asn Val His Lys Lys Arg Val 
            980                 985                 990         


Ser Ala Ala Arg Leu Leu Ser Arg  Gln Asn Leu Gln Ser  Pro Lys Phe 
        995                 1000                 1005             


Ser Arg  Ser Thr Ile Phe Val  Arg Leu His Thr Asn  Gly Asn Gln 
    1010                 1015                 1020             


Glu Leu  Gln Tyr Gln Pro Gly  Asp His Leu Gly Val  Phe Pro Gly 
    1025                 1030                 1035             


Asn His  Glu Asp Leu Val Asn  Ala Leu Ile Glu Arg  Leu Glu Asp 
    1040                 1045                 1050             


Ala Pro  Pro Ala Asn His Val  Val Lys Val Glu Met  Leu Glu Glu 
    1055                 1060                 1065             


Arg Asn  Thr Ala Leu Gly Val  Ile Ser Asn Trp Lys  Asp Glu Ser 
    1070                 1075                 1080             


Arg Leu  Pro Pro Cys Thr Ile  Phe Gln Ala Phe Lys  Tyr Tyr Leu 
    1085                 1090                 1095             


Asp Ile  Thr Thr Pro Pro Thr  Pro Leu Gln Leu Gln  Gln Phe Ala 
    1100                 1105                 1110             


Ser Leu  Ala Thr Asn Glu Lys  Glu Lys Gln Arg Leu  Leu Val Leu 
    1115                 1120                 1125             


Ser Lys  Gly Leu Gln Glu Tyr  Glu Glu Trp Lys Trp  Gly Lys Asn 
    1130                 1135                 1140             


Pro Thr  Met Val Glu Val Leu  Glu Glu Phe Pro Ser  Ile Gln Met 
    1145                 1150                 1155             


Pro Ala  Thr Leu Leu Leu Thr  Gln Leu Ser Leu Leu  Gln Pro Arg 
    1160                 1165                 1170             


Tyr Tyr  Ser Ile Ser Ser Ser  Pro Asp Met Tyr Pro  Asp Glu Val 
    1175                 1180                 1185             


His Leu  Thr Val Ala Ile Val  Ser Tyr His Thr Arg  Asp Gly Glu 
    1190                 1195                 1200             


Gly Pro  Val His His Gly Val  Cys Ser Ser Trp Leu  Asn Arg Ile 
    1205                 1210                 1215             


Gln Ala  Asp Asp Val Val Pro  Cys Phe Val Arg Gly  Ala Pro Ser 
    1220                 1225                 1230             


Phe His  Leu Pro Arg Asn Pro  Gln Val Pro Cys Ile  Leu Val Gly 
    1235                 1240                 1245             


Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Ser Phe Trp  Gln Gln Arg 
    1250                 1255                 1260             


Gln Phe  Asp Ile Gln His Lys  Gly Met Asn Pro Cys  Pro Met Val 
    1265                 1270                 1275             


Leu Val  Phe Gly Cys Arg Gln  Ser Lys Ile Asp His  Ile Tyr Arg 
    1280                 1285                 1290             


Glu Glu  Thr Leu Gln Ala Lys  Asn Lys Gly Val Phe  Arg Glu Leu 
    1295                 1300                 1305             


Tyr Thr  Ala Tyr Ser Arg Glu  Pro Asp Arg Pro Lys  Lys Tyr Val 
    1310                 1315                 1320             


Gln Asp  Val Leu Gln Glu Gln  Leu Ala Glu Ser Val  Tyr Arg Ala 
    1325                 1330                 1335             


Leu Lys  Glu Gln Gly Gly His  Ile Tyr Val Cys Gly  Asp Val Thr 
    1340                 1345                 1350             


Met Ala  Ala Asp Val Leu Lys  Ala Ile Gln Arg Ile  Met Thr Gln 
    1355                 1360                 1365             


Gln Gly  Lys Leu Ser Glu Glu  Asp Ala Gly Val Phe  Ile Ser Arg 
    1370                 1375                 1380             


Leu Arg  Asp Asp Asn Arg Tyr  His Glu Asp Ile Phe  Gly Val Thr 
    1385                 1390                 1395             


Leu Arg  Thr Tyr Glu Val Thr  Asn Arg Leu Arg Ser  Glu Ser Ile 
    1400                 1405                 1410             


Ala Phe  Ile Glu Glu Ser Lys  Lys Asp Ala Asp Glu  Val Phe Ser 
    1415                 1420                 1425             


Ser 
    


<210>  12
<211>  1429
<212>  PRT
<213>  Mus musculus

<400>  12

Met Glu Glu His Thr Phe Gly Val Gln Gln Ile Gln Pro Asn Val Ile 
1               5                   10                  15      


Ser Val Arg Leu Phe Lys Arg Lys Val Gly Gly Leu Gly Phe Leu Val 
            20                  25                  30          


Lys Glu Arg Val Ser Lys Pro Pro Val Ile Ile Ser Asp Leu Ile Arg 
        35                  40                  45              


Gly Gly Ala Ala Glu Gln Ser Gly Leu Ile Gln Ala Gly Asp Ile Ile 
    50                  55                  60                  


Leu Ala Val Asn Asp Arg Pro Leu Val Asp Leu Ser Tyr Asp Ser Ala 
65                  70                  75                  80  


Leu Glu Val Leu Arg Gly Ile Ala Ser Glu Thr His Val Val Leu Ile 
                85                  90                  95      


Leu Arg Gly Pro Glu Gly Phe Thr Thr His Leu Glu Thr Thr Phe Thr 
            100                 105                 110         


Gly Asp Gly Thr Pro Lys Thr Ile Arg Val Thr Gln Pro Leu Gly Thr 
        115                 120                 125             


Pro Thr Lys Ala Val Asp Leu Ser Arg Gln Pro Ser Ala Ser Lys Asp 
    130                 135                 140                 


Gln Pro Leu Ala Val Asp Arg Val Pro Gly Pro Ser Asn Gly Pro Gln 
145                 150                 155                 160 


His Ala Gln Gly Arg Gly Gln Gly Ala Gly Ser Val Ser Gln Ala Asn 
                165                 170                 175     


Gly Val Ala Ile Asp Pro Thr Met Lys Asn Thr Lys Ala Asn Leu Gln 
            180                 185                 190         


Asp Ser Gly Glu Gln Asp Glu Leu Leu Lys Glu Ile Glu Pro Val Leu 
        195                 200                 205             


Ser Ile Leu Thr Gly Gly Gly Lys Ala Val Asn Arg Gly Gly Pro Ala 
    210                 215                 220                 


Lys Ala Glu Met Lys Asp Thr Gly Ile Gln Val Asp Arg Asp Leu Asp 
225                 230                 235                 240 


Gly Lys Leu His Lys Ala Pro Pro Leu Gly Gly Glu Asn Asp Arg Val 
                245                 250                 255     


Phe Asn Asp Leu Trp Gly Lys Gly Asn Val Pro Val Val Leu Asn Asn 
            260                 265                 270         


Pro Tyr Ser Glu Asn Glu Gln Ser Pro Ala Ser Gly Lys Gln Ser Pro 
        275                 280                 285             


Thr Lys Asn Gly Ser Pro Ser Arg Cys Pro Arg Phe Leu Lys Val Lys 
    290                 295                 300                 


Asn Trp Glu Thr Asp Val Val Leu Thr Asp Thr Leu His Leu Lys Ser 
305                 310                 315                 320 


Thr Leu Glu Thr Gly Cys Thr Glu Gln Ile Cys Met Gly Ser Ile Met 
                325                 330                 335     


Leu Pro Ser His His Ile Arg Lys Ser Glu Asp Val Arg Thr Lys Asp 
            340                 345                 350         


Gln Leu Phe Pro Leu Ala Lys Glu Phe Leu Asp Gln Tyr Tyr Ser Ser 
        355                 360                 365             


Ile Lys Arg Phe Gly Ser Lys Ala His Met Asp Arg Leu Glu Glu Val 
    370                 375                 380                 


Asn Lys Glu Ile Glu Ser Thr Ser Thr Tyr Gln Leu Lys Asp Thr Glu 
385                 390                 395                 400 


Leu Ile Tyr Gly Ala Lys His Ala Trp Arg Asn Ala Ser Arg Cys Val 
                405                 410                 415     


Gly Arg Ile Gln Trp Ser Lys Leu Gln Val Phe Asp Ala Arg Asp Cys 
            420                 425                 430         


Thr Thr Ala His Gly Met Phe Asn Tyr Ile Cys Asn His Val Lys Tyr 
        435                 440                 445             


Ala Thr Asn Lys Gly Asn Leu Arg Ser Ala Ile Thr Ile Phe Pro Gln 
    450                 455                 460                 


Arg Thr Asp Gly Lys His Asp Phe Arg Val Trp Asn Ser Gln Leu Ile 
465                 470                 475                 480 


Arg Tyr Ala Gly Tyr Lys Gln Pro Asp Gly Ser Thr Leu Gly Asp Pro 
                485                 490                 495     


Ala Asn Val Glu Phe Thr Glu Ile Cys Ile Gln Gln Gly Trp Lys Pro 
            500                 505                 510         


Pro Arg Gly Arg Phe Asp Val Leu Pro Leu Leu Leu Gln Ala Asn Gly 
        515                 520                 525             


Asn Asp Pro Glu Leu Phe Gln Ile Pro Pro Glu Leu Val Leu Glu Val 
    530                 535                 540                 


Pro Ile Arg His Pro Lys Phe Asp Trp Phe Lys Asp Leu Gly Leu Lys 
545                 550                 555                 560 


Trp Tyr Gly Leu Pro Ala Val Ser Asn Met Leu Leu Glu Ile Gly Gly 
                565                 570                 575     


Leu Glu Phe Ser Ala Cys Pro Phe Ser Gly Trp Tyr Met Gly Thr Glu 
            580                 585                 590         


Ile Gly Val Arg Asp Tyr Cys Asp Asn Ser Arg Tyr Asn Ile Leu Glu 
        595                 600                 605             


Glu Val Ala Lys Lys Met Asp Leu Asp Met Arg Lys Thr Ser Ser Leu 
    610                 615                 620                 


Trp Lys Asp Gln Ala Leu Val Glu Ile Asn Ile Ala Val Leu Tyr Ser 
625                 630                 635                 640 


Phe Gln Ser Asp Lys Val Thr Ile Val Asp His His Ser Ala Thr Glu 
                645                 650                 655     


Ser Phe Ile Lys His Met Glu Asn Glu Tyr Arg Cys Arg Gly Gly Cys 
            660                 665                 670         


Pro Ala Asp Trp Val Trp Ile Val Pro Pro Met Ser Gly Ser Ile Thr 
        675                 680                 685             


Pro Val Phe His Gln Glu Met Leu Asn Tyr Arg Leu Thr Pro Ser Phe 
    690                 695                 700                 


Glu Tyr Gln Pro Asp Pro Trp Asn Thr His Val Trp Lys Gly Thr Asn 
705                 710                 715                 720 


Gly Thr Pro Thr Lys Arg Arg Ala Ile Gly Phe Lys Lys Leu Ala Glu 
                725                 730                 735     


Ala Val Lys Phe Ser Ala Lys Leu Met Gly Gln Ala Met Ala Lys Arg 
            740                 745                 750         


Val Lys Ala Thr Ile Leu Tyr Ala Thr Glu Thr Gly Lys Ser Gln Ala 
        755                 760                 765             


Tyr Ala Lys Thr Leu Cys Glu Ile Phe Lys His Ala Phe Asp Ala Lys 
    770                 775                 780                 


Ala Met Ser Met Glu Glu Tyr Asp Ile Val His Leu Glu His Glu Ala 
785                 790                 795                 800 


Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn Gly Asp Pro Pro Glu 
                805                 810                 815     


Asn Gly Glu Lys Phe Gly Cys Ala Leu Met Glu Met Arg His Pro Asn 
            820                 825                 830         


Ser Val Gln Glu Glu Arg Lys Ser Tyr Lys Val Arg Phe Asn Ser Val 
        835                 840                 845             


Ser Ser Tyr Ser Asp Ser Arg Lys Ser Ser Gly Asp Gly Pro Asp Leu 
    850                 855                 860                 


Arg Asp Asn Phe Glu Ser Thr Gly Pro Leu Ala Asn Val Arg Phe Ser 
865                 870                 875                 880 


Val Phe Gly Leu Gly Ser Arg Ala Tyr Pro His Phe Cys Ala Phe Gly 
                885                 890                 895     


His Ala Val Asp Thr Leu Leu Glu Glu Leu Gly Gly Glu Arg Ile Leu 
            900                 905                 910         


Lys Met Arg Glu Gly Asp Glu Leu Cys Gly Gln Glu Glu Ala Phe Arg 
        915                 920                 925             


Thr Trp Ala Lys Lys Val Phe Lys Ala Ala Cys Asp Val Phe Cys Val 
    930                 935                 940                 


Gly Asp Asp Val Asn Ile Glu Lys Ala Asn Asn Ser Leu Ile Ser Asn 
945                 950                 955                 960 


Asp Arg Ser Trp Lys Arg Asn Lys Phe Arg Leu Thr Tyr Val Ala Glu 
                965                 970                 975     


Ala Pro Glu Leu Thr Gln Gly Leu Ser Asn Val His Lys Lys Arg Val 
            980                 985                 990         


Ser Ala Ala Arg Leu Leu Ser Arg  Gln Asn Leu Gln Ser  Pro Lys Ser 
        995                 1000                 1005             


Ser Arg  Ser Thr Ile Phe Val  Arg Leu His Thr Asn  Gly Asn Gln 
    1010                 1015                 1020             


Glu Leu  Gln Tyr Gln Pro Gly  Asp His Leu Gly Val  Phe Pro Gly 
    1025                 1030                 1035             


Asn His  Glu Asp Leu Val Asn  Ala Leu Ile Glu Arg  Leu Glu Asp 
    1040                 1045                 1050             


Ala Pro  Pro Ala Asn His Val  Val Lys Val Glu Met  Leu Glu Glu 
    1055                 1060                 1065             


Arg Asn  Thr Ala Leu Gly Val  Ile Ser Asn Trp Lys  Asp Glu Ser 
    1070                 1075                 1080             


Arg Leu  Pro Pro Cys Thr Ile  Phe Gln Ala Phe Lys  Tyr Tyr Leu 
    1085                 1090                 1095             


Asp Ile  Thr Thr Pro Pro Thr  Pro Leu Gln Leu Gln  Gln Phe Ala 
    1100                 1105                 1110             


Ser Leu  Ala Thr Asn Glu Lys  Glu Lys Gln Arg Leu  Leu Val Leu 
    1115                 1120                 1125             


Ser Lys  Gly Leu Gln Glu Tyr  Glu Glu Trp Lys Trp  Gly Lys Asn 
    1130                 1135                 1140             


Pro Thr  Met Val Glu Val Leu  Glu Glu Phe Pro Ser  Ile Gln Met 
    1145                 1150                 1155             


Pro Ala  Thr Leu Leu Leu Thr  Gln Leu Ser Leu Leu  Gln Pro Arg 
    1160                 1165                 1170             


Tyr Tyr  Ser Ile Ser Ser Ser  Pro Asp Met Tyr Pro  Asp Glu Val 
    1175                 1180                 1185             


His Leu  Thr Val Ala Ile Val  Ser Tyr His Thr Arg  Asp Gly Glu 
    1190                 1195                 1200             


Gly Pro  Val His His Gly Val  Cys Ser Ser Trp Leu  Asn Arg Ile 
    1205                 1210                 1215             


Gln Ala  Asp Asp Val Val Pro  Cys Phe Val Arg Gly  Ala Pro Ser 
    1220                 1225                 1230             


Phe His  Leu Pro Arg Asn Pro  Gln Val Pro Cys Ile  Leu Val Gly 
    1235                 1240                 1245             


Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Ser Phe Trp  Gln Gln Arg 
    1250                 1255                 1260             


Gln Phe  Asp Ile Gln His Lys  Gly Met Asn Pro Cys  Pro Met Val 
    1265                 1270                 1275             


Leu Val  Phe Gly Cys Arg Gln  Ser Lys Ile Asp His  Ile Tyr Arg 
    1280                 1285                 1290             


Glu Glu  Thr Leu Gln Ala Lys  Asn Lys Gly Val Phe  Arg Glu Leu 
    1295                 1300                 1305             


Tyr Thr  Ala Tyr Ser Arg Glu  Pro Asp Arg Pro Lys  Lys Tyr Val 
    1310                 1315                 1320             


Gln Asp  Val Leu Gln Glu Gln  Leu Ala Glu Ser Val  Tyr Arg Ala 
    1325                 1330                 1335             


Leu Lys  Glu Gln Gly Gly His  Ile Tyr Val Cys Gly  Asp Val Thr 
    1340                 1345                 1350             


Met Ala  Ala Asp Val Leu Lys  Ala Ile Gln Arg Ile  Met Thr Gln 
    1355                 1360                 1365             


Gln Gly  Lys Leu Ser Glu Glu  Asp Ala Gly Val Phe  Ile Ser Arg 
    1370                 1375                 1380             


Leu Arg  Asp Asp Asn Arg Tyr  His Glu Asp Ile Phe  Gly Val Thr 
    1385                 1390                 1395             


Leu Arg  Thr Tyr Glu Val Thr  Asn Arg Leu Arg Ser  Glu Ser Ile 
    1400                 1405                 1410             


Ala Phe  Ile Glu Glu Ser Lys  Lys Asp Thr Asp Glu  Val Phe Ser 
    1415                 1420                 1425             


Ser 
    


<210>  13
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Arg Arg Arg Ile Thr Ser Ala Ala Arg Arg Ser Tyr Val Ser 
1               5                   10                  15      


Ser Gly Glu Met Met Val Gly Gly Leu Ala Pro Gly Arg Arg Leu Gly 
            20                  25                  30          


Pro Gly Thr Arg Leu Ser Leu Ala Arg Met Pro Pro Pro Leu Pro Thr 
        35                  40                  45              


Arg Val Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu 
    50                  55                  60                  


Thr Arg Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe 
65                  70                  75                  80  


Ala Ser Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala 
                85                  90                  95      


Leu Ala Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu 
            100                 105                 110         


Ala Asp Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp 
        115                 120                 125             


Gln Leu Thr Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu 
    130                 135                 140                 


Ala Gln Asp Leu Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn 
145                 150                 155                 160 


Leu Arg Leu Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala 
                165                 170                 175     


Asp Glu Ala Thr Leu Ala Arg Leu Asp Leu Glu Arg Lys Ile Glu Ser 
            180                 185                 190         


Leu Glu Glu Glu Ile Arg Phe Leu Arg Lys Ile His Glu Glu Glu Val 
        195                 200                 205             


Arg Glu Leu Gln Glu Gln Leu Ala Arg Gln Gln Val His Val Glu Leu 
    210                 215                 220                 


Asp Val Ala Lys Pro Asp Leu Thr Ala Ala Leu Lys Glu Ile Arg Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Met Ala Ser Ser Asn Met His Glu Ala Glu Glu Trp 
                245                 250                 255     


Tyr Arg Ser Lys Phe Ala Asp Leu Thr Asp Ala Ala Ala Arg Asn Ala 
            260                 265                 270         


Glu Leu Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln 
        275                 280                 285             


Leu Gln Ser Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu 
    290                 295                 300                 


Ser Leu Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Val Arg Glu 
305                 310                 315                 320 


Ala Ala Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln 
                325                 330                 335     


Ser Leu Lys Asp Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu 
            340                 345                 350         


Leu Asn Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys 
        355                 360                 365             


Leu Leu Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe 
    370                 375                 380                 


Ser Asn Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser 
385                 390                 395                 400 


Glu Gly His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg 
                405                 410                 415     


Asp Gly Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430         


<210>  14
<211>  430
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Glu Arg Arg Arg Ile Thr Ser Ala Arg Arg Ser Tyr Ala Ser Ser 
1               5                   10                  15      


Glu Thr Met Val Arg Gly His Gly Pro Thr Arg His Leu Gly Thr Ile 
            20                  25                  30          


Pro Arg Leu Ser Leu Ser Arg Met Thr Pro Pro Leu Pro Ala Arg Val 
        35                  40                  45              


Asp Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu Thr Arg 
    50                  55                  60                  


Ala Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe Ala Ser 
65                  70                  75                  80  


Tyr Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala Leu Ala 
                85                  90                  95      


Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala Asp 
            100                 105                 110         


Val Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln Leu 
        115                 120                 125             


Thr Thr Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Leu Thr Gln 
    130                 135                 140                 


Asp Leu Gly Thr Leu Arg Gln Lys Leu Gln Asp Glu Thr Asn Leu Arg 
145                 150                 155                 160 


Leu Glu Ala Glu Asn Asn Leu Ala Val Tyr Arg Gln Glu Ala Asp Glu 
                165                 170                 175     


Ala Thr Leu Ala Arg Val Asp Leu Glu Arg Lys Val Glu Ser Leu Glu 
            180                 185                 190         


Glu Glu Ile Gln Phe Leu Arg Lys Ile His Glu Glu Glu Val Arg Glu 
        195                 200                 205             


Leu Gln Glu Gln Leu Ala Gln Gln Gln Val His Val Glu Met Asp Val 
    210                 215                 220                 


Ala Lys Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg Thr Gln Tyr 
225                 230                 235                 240 


Glu Ala Val Ala Thr Ser Asn Met Gln Glu Thr Glu Glu Trp Tyr Arg 
                245                 250                 255     


Ser Lys Phe Ala Asp Leu Thr Asp Val Ala Ser Arg Asn Ala Glu Leu 
            260                 265                 270         


Leu Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln Leu Gln 
        275                 280                 285             


Ala Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu Ser Leu 
    290                 295                 300                 


Glu Arg Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg Glu Ser Ala 
305                 310                 315                 320 


Ser Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln Ser Leu 
                325                 330                 335     


Lys Glu Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu Asn 
            340                 345                 350         


Val Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu 
        355                 360                 365             


Glu Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe Ser Asn 
    370                 375                 380                 


Leu Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser Glu Gly 
385                 390                 395                 400 


His Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg Asp Gly 
                405                 410                 415     


Glu Val Ile Lys Glu Ser Lys Gln Glu His Lys Asp Val Met 
            420                 425                 430 


<210>  15
<211>  430
<212>  PRT
<213>  Mus musculus

<400>  15

Met Glu Arg Arg Arg Ile Thr Ser Ala Arg Arg Ser Tyr Ala Ser Glu 
1               5                   10                  15      


Thr Val Val Arg Gly Leu Gly Pro Ser Arg Gln Leu Gly Thr Met Pro 
            20                  25                  30          


Arg Phe Ser Leu Ser Arg Met Thr Pro Pro Leu Pro Ala Arg Val Asp 
        35                  40                  45              


Phe Ser Leu Ala Gly Ala Leu Asn Ala Gly Phe Lys Glu Thr Arg Ala 
    50                  55                  60                  


Ser Glu Arg Ala Glu Met Met Glu Leu Asn Asp Arg Phe Ala Ser Tyr 
65                  70                  75                  80  


Ile Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Ala Leu Ala Ala 
                85                  90                  95      


Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala Asp Val 
            100                 105                 110         


Tyr Gln Ala Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln Leu Thr 
        115                 120                 125             


Ala Asn Ser Ala Arg Leu Glu Val Glu Arg Asp Asn Phe Ala Gln Asp 
    130                 135                 140                 


Leu Gly Thr Leu Arg Gln Lys Leu Gln Asp Glu Thr Asn Leu Arg Leu 
145                 150                 155                 160 


Glu Ala Glu Asn Asn Leu Ala Ala Tyr Arg Gln Glu Ala Asp Glu Ala 
                165                 170                 175     


Thr Leu Ala Arg Val Asp Leu Glu Arg Lys Val Glu Ser Leu Glu Glu 
            180                 185                 190         


Glu Ile Gln Phe Leu Arg Lys Ile Tyr Glu Glu Glu Val Arg Glu Leu 
        195                 200                 205             


Arg Glu Gln Leu Ala Gln Gln Gln Val His Val Glu Met Asp Val Ala 
    210                 215                 220                 


Lys Pro Asp Leu Thr Ala Ala Leu Arg Glu Ile Arg Thr Gln Tyr Glu 
225                 230                 235                 240 


Ala Val Ala Thr Ser Asn Met Gln Glu Thr Glu Glu Trp Tyr Arg Ser 
                245                 250                 255     


Lys Phe Ala Asp Leu Thr Asp Ala Ala Ser Arg Asn Ala Glu Leu Leu 
            260                 265                 270         


Arg Gln Ala Lys His Glu Ala Asn Asp Tyr Arg Arg Gln Leu Gln Ala 
        275                 280                 285             


Leu Thr Cys Asp Leu Glu Ser Leu Arg Gly Thr Asn Glu Ser Leu Glu 
    290                 295                 300                 


Arg Gln Met Arg Glu Gln Glu Glu Arg His Ala Arg Glu Ser Ala Ser 
305                 310                 315                 320 


Tyr Gln Glu Ala Leu Ala Arg Leu Glu Glu Glu Gly Gln Ser Leu Lys 
                325                 330                 335     


Glu Glu Met Ala Arg His Leu Gln Glu Tyr Gln Asp Leu Leu Asn Val 
            340                 345                 350         


Lys Leu Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu 
        355                 360                 365             


Gly Glu Glu Asn Arg Ile Thr Ile Pro Val Gln Thr Phe Ser Asn Leu 
    370                 375                 380                 


Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser Glu Gly His 
385                 390                 395                 400 


Leu Lys Arg Asn Ile Val Val Lys Thr Val Glu Met Arg Asp Gly Glu 
                405                 410                 415     


Val Ile Lys Asp Ser Lys Gln Glu His Lys Asp Val Val Met 
            420                 425                 430 


<210>  16
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Ala Glu Gln Gly Gly Thr Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Gly Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Met Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Ala Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Ser Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Ala Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ser Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210>  17
<211>  466
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Ser Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Thr Asp Gln Gly Gly Ala Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Glu Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Leu Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Thr Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Gly Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Ser Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Ala Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Thr Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ala Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210>  18
<211>  466
<212>  PRT
<213>  Mus musculus

<400>  18

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Ala Glu Gln Gly Gly Ala Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Glu Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Leu Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Thr Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Gly Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Thr Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ala Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210>  19
<211>  1589
<212>  DNA
<213>  Homo sapiens

<400>  19
ggaaaaaagg aaagtgcact tggaagagat ccaagtgggc aacttgaaga acaagtgcca       60

aatagcactt ctgtcatgct ggatgtcagg gctctttgtc cactttgtat agccgctggc      120

ttatagaagg tgctcgataa atctcttgaa tttaaaaatc aattaggatg cctctatagt      180

gaaaaagata cagtaaagat gagggataat caatttaaaa aatgagtaag tacacacaaa      240

gcactttatc cattcttatg acacctgtta cttttttgct gtgtttgtgt gtatgcatgc      300

catgttatag tttgtgggac cctcaaagca agctggggag agtatatact gaatttagct      360

tctgagacat gatgctcttc ctttttaatt aacccagaac ttagcagctt atctatttct      420

ctaatctcaa aacatcctta aactgggggt gatacttgag tgagagaatt ttgcaggtat      480

taaatgaact atcttctttt ttttttttct ttgagacaga gtcttgctct gtcacccagg      540

ctggagtgca gtggcgtgat ctcagctcac tgcaacctcc gcctcccggg ttcaagtgat      600

tctcctgcct cagcctcctg agtagctggg attacagtcc caggacatca aagctctgca      660

gaaagaactc gagcaatttg ccaagctcct gaagcagaag aggatcaccc tgggatatac      720

acaggccgat gtggggctca ccctgggggt tctatttggg aaggtattca gccaaacgac      780

catctgccgc tttgaggctc tgcagcttag cttcaagaac atgtgtaagc tgcggccctt      840

gctgcagaag tgggtggagg aagctgacaa caatgaaaat cttcaggaga tatgcaaagc      900

agaaaccctc gtgcaggccc gaaagagaaa gcgaaccagt atcgagaacc gagtgagagg      960

caacctggag aatttgttcc tgcagtgccc gaaacccaca ctgcagcaga tcagccacat     1020

cgcccagcag cttgggctcg agaaggatgt ggtccgagtg tggttctgta accggcgcca     1080

gaagggcaag cgatcaagca gcgactatgc acaacgagag gattttgagg ctgctgggtc     1140

tcctttctca gggggaccag tgtcctttcc tctggcccca gggccccatt ttggtacccc     1200

aggctatggg agccctcact tcactgcact gtactcctcg gtccctttcc ctgaggggga     1260

agcctttccc cctgtctccg tcaccactct gggctctccc atgcattcaa actgaggtgc     1320

ctgcccttct aggaatgggg gacaggggga ggggaggagc tagggaaaga aaacctggag     1380

tttgtgccag ggtttttggg attaagttct tcattcacta aggaaggaat tgggaacaca     1440

aagggtgggg gcaggggagt ttggggcaac tggttggagg gaaggtgaag ttcaatgatg     1500

ctcttgattt taatcccaca tcatgtatca cttttttctt aaataaagaa gcctgggaca     1560

cagtagatag acacacttaa aaaaaaaaa                                       1589


<210>  20
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Val Leu Phe Gly Lys Val Phe Ser Gln Thr Thr Ile Cys Arg 
1               5                   10                  15      


Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn Met Cys Lys Leu Arg Pro 
            20                  25                  30          


Leu Leu Gln Lys Trp Val Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln 
        35                  40                  45              


Glu Ile Cys Lys Ala Glu Thr Leu Val Gln Ala Arg Lys Arg Lys Arg 
    50                  55                  60                  


Thr Ser Ile Glu Asn Arg Val Arg Gly Asn Leu Glu Asn Leu Phe Leu 
65                  70                  75                  80  


Gln Cys Pro Lys Pro Thr Leu Gln Gln Ile Ser His Ile Ala Gln Gln 
                85                  90                  95      


Leu Gly Leu Glu Lys Asp Val Val Arg Val Trp Phe Cys Asn Arg Arg 
            100                 105                 110         


Gln Lys Gly Lys Arg Ser Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe 
        115                 120                 125             


Glu Ala Ala Gly Ser Pro Phe Ser Gly Gly Pro Val Ser Phe Pro Leu 
    130                 135                 140                 


Ala Pro Gly Pro His Phe Gly Thr Pro Gly Tyr Gly Ser Pro His Phe 
145                 150                 155                 160 


Thr Ala Leu Tyr Ser Ser Val Pro Phe Pro Glu Gly Glu Ala Phe Pro 
                165                 170                 175     


Pro Val Ser Val Thr Thr Leu Gly Ser Pro Met His Ser Asn 
            180                 185                 190 


<210>  21
<211>  2049
<212>  DNA
<213>  Homo sapiens

<400>  21
ataaatctag agactccagg attttaacgt tctgctggac tgagctggtt gcctcatgtt       60

attatgcagg caactcactt tatcccaatt tcttgatact tttccttctg gaggtcctat      120

ttctctaaca tcttccagaa aagtcttaaa gctgccttaa ccttttttcc agtccacctc      180

ttaaattttt tcctcctctt cctctatact aacatgagtg tggatccagc ttgtccccaa      240

agcttgcctt gctttgaagc atccgactgt aaagaatctt cacctatgcc tgtgatttgt      300

gggcctgaag aaaactatcc atccttgcaa atgtcttctg ctgagatgcc tcacacggag      360

actgtctctc ctcttccttc ctccatggat ctgcttattc aggacagccc tgattcttcc      420

accagtccca aaggcaaaca acccacttct gcagagaaga gtgtcgcaaa aaaggaagac      480

aaggtcccgg tcaagaaaca gaagaccaga actgtgttct cttccaccca gctgtgtgta      540

ctcaatgata gatttcagag acagaaatac ctcagcctcc agcagatgca agaactctcc      600

aacatcctga acctcagcta caaacaggtg aagacctggt tccagaacca gagaatgaaa      660

tctaagaggt ggcagaaaaa caactggccg aagaatagca atggtgtgac gcagggatgc      720

ctggtgaacc cgactgggaa ccttccaatg tggagcaacc agacctggaa caattcaacc      780

tggagcaacc agacccagaa catccagtcc tggagcaacc actcctggaa cactcagacc      840

tggtgcaccc aatcctggaa caatcaggcc tggaacagtc ccttctataa ctgtggagag      900

gaatctctgc agtcctgcat gcagttccag ccaaattctc ctgccagtga cttggaggct      960

gccttggaag ctgctgggga aggccttaat gtaatacagc agaccactag gtattttagt     1020

actccacaaa ccatggattt attcctaaac tactccatga acatgcaacc tgaagacgtg     1080

tgaagatgag tgaaactgat attactcaat ttcagtctgg acactggctg aatccttcct     1140

ctcccctcct cccatccctc ataggatttt tcttgtttgg aaaccacgtg ttctggtttc     1200

catgatgccc atccagtcaa tctcatggag ggtggagtat ggttggagcc taatcagcga     1260

ggtttctttt tttttttttt tcctattgga tcttcctgga gaaaatactt tttttttttt     1320

tttttttgaa acggagtctt gctctgtcgc ccaggctgga gtgcagtggc gcggtcttgg     1380

ctcactgcaa gctccgtctc ccgggttcac gccattctcc tgcctcagcc tcccgagcag     1440

ctgggactac aggcgcccgc cacctcgccc ggctaatatt ttgtattttt agtagagacg     1500

gggtttcact gtgttagcca ggatggtctc gatctcctga ccttgtgatc cacccgcctc     1560

ggcctcccta acagctggga tttacaggcg tgagccaccg cgccctgcct agaaaagaca     1620

ttttaataac cttggctgcc gtctctggct atagataagt agatctaata ctagtttgga     1680

tatctttagg gtttagaatc taacctcaag aataagaaat acaagtacaa attggtgatg     1740

aagatgtatt cgtattgttt gggattggga ggctttgctt attttttaaa aactattgag     1800

gtaaagggtt aagctgtaac atacttaatt gatttcttac cgtttttggc tctgttttgc     1860

tatatcccct aatttgttgg ttgtgctaat ctttgtagaa agaggtctcg tatttgctgc     1920

atcgtaatga catgagtact gctttagttg gtttaagttc aaatgaatga aacaactatt     1980

tttcctttag ttgattttac cctgatttca ccgagtgttt caatgagtaa atatacagct     2040

taaacataa                                                             2049


<210>  22
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
                165                 170                 175     


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
            180                 185                 190         


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
        195                 200                 205             


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
    210                 215                 220                 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
225                 230                 235                 240 


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
                245                 250                 255     


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
            260                 265                 270         


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
        275                 280                 285             


Val 
    


<210>  23
<211>  2441
<212>  DNA
<213>  Homo sapiens

<400>  23
gactatcaca caactatttc cttggatgta attctttgtt accctttaca agtataagtg       60

ttaccttaca tggaaacgaa gaaacaaaat tcataaattt aaattcataa atttagctga      120

aagatactga ttcaatttgt atacagtgaa tataaatgag acgacagcaa aattttcatg      180

aaatgtaaaa tatttttata gtttgttcat actatatgag gttctatttt aaatgacttt      240

ctggatttta aaaaatttct ttaaatacaa tcatttttgt aatatttatt ttatgcttat      300

gatctagata attgcagaat atcattttat ctgactctgc cttcataaga gagctgtggc      360

cgaattttga acatctgtta tagggagtga tcaaattaga aggcaatgtg gaaaaacaat      420

tctgggaaag atttctttat atgaagtccc tgccactagc cagccatcct aattgatgaa      480

agttatctgt tcacaggcct gcagtgatgg tgaggaatgt tctgagattt gcgaaggcat      540

ttgagtagtg aaatgtaagc acaaaacctc ctgaacccag agtgtgtata cacaggaata      600

aactttatga catttatgta tttttaaaaa actttgtatc gttataaaaa ggctagtcat      660

tctttcagga gaacatctag gatcatagat gaaaaatcaa gccccgattt agaactgtct      720

tctccaggat ggtctctaag gaaatttaca tttggttctt tcctactcag aactactcag      780

aaacaactat atatttcagg ttatctgagc acagtgaaag cagagtacta tggttgtcca      840

acacaggcct ctcagataca aggggaacac aattacatat tgggctagat tttgcccagt      900

tcaaaatagt atttgttatc aacttacttt gttacttgta tcatgaattt taaaacccta      960

ccactttaag aagacaggga tgggttattc ttttttggca ggtaggctat ataactatgt     1020

gattttgaaa tttaactgct ctggattagg gagcagtgaa tcaaggcaga cttatgaaat     1080

ctgtattata tttgtaacag aatataggaa atttaacata attgatgagc tcaaatcctg     1140

aaaaatgaaa gaatccaaat tatttcagaa ttatctaggt taaatattga tgtattatga     1200

tggttgcaaa gtttttttgt gtgtccaata aacacattgt aaaaaaaaga atttgaattg     1260

atatctaaaa acagaatttg aattgatatt tcatcttgac ttttaaagcc ctagaggcta     1320

attgttagta acatcaattt ctattaggat atccgtttgg ccacacagca ggaggttaga     1380

gcaatggagc attactgagt tcctccccct gtcagatcag cagcagcatt agattctcat     1440

agaagtgcga accatatggt gaactggtat gtgagggatc tagagtgcca tgttcctcaa     1500

gagaatctaa tgcctgatga tctgaggtgg aacagttcat cctgaaacca ttcccccatc     1560

cacggaaaaa ttgtcttcca tgaaactggt cccaaaaagg gtggggacca caggtttaaa     1620

gcatggccac atttctttat attaaaattc tagtttgtac atttctttta gaaacaatta     1680

catgttactt tggaatcatt tcttccatgc ttcctccata aagactgata agtcttggat     1740

gcaatctgta aagaaaatac attatttcat caacttattt tgttgttttt cacatacacc     1800

taataagtat ggtacacaat gccaatgcca aatacaaatt gataacaaac acagcattcc     1860

caacagagct gtaatctaga aaactgagaa ggtctgattg ataaatcatc aacaacaata     1920

attgctctaa aacctcctta actgacttcc ttgattgtcc aatgctctcc attacctctg     1980

taaaacagtc agttatgcct ctagaacacc catgtctagt gggcacccct gcatgcttct     2040

tctaaccact gagtgtcaca atgcctacca agaatgcgtt tgcaggttcc taaacctgtt     2100

tataccagtt gctatgtaaa attgttccca agggaagttg aatgctctgt aaaggcctaa     2160

taaaagcaaa ttactgaaca aaacatgtta cagtaattat gagtgagagg aaactaagat     2220

ggaaggataa aaatctaaca ctttactatt cagatggctc cactaaaaga tttaagatct     2280

tgatccattt ttaaaaatcc aaaatggaag ttgtagacat tatctgtagt ttatgcacaa     2340

caataaatta gaaagccaat gtagacacgc ataaccaaag aaaatgcctt gggtctacat     2400

aacagttgaa taaatgtaaa gttgcttttt atttattgaa a                         2441


<210>  24
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  25
<211>  2395
<212>  DNA
<213>  Homo sapiens

<400>  25
gacgatgaca agttccccgt gtgcatccgc gaggccgtca gccaggtgct cagcggctac       60

gactggacgc tggtgcccat gcccgtgcgc gtcaacggcg ccagcaaaag caagccgcac      120

gtcaagcggc ccatgaacgc cttcatggtg tgggctcagg cagcgcgcag gaagctcgcg      180

gaccagtacc cgcacctgca caacgctgag ctcagcaaga cgctgggcaa gctctggagg      240

ctgctgaacg aaagtgacaa gcgccccttc atcgaggagg ctgagcggct ccgtatgcag      300

cacaagaaag accacccgga ctacaagtac cagcccaggc ggcggaagaa cgggaaggcc      360

gcccagggcg aggcggagtg ccccggtggg gaggccgagc aaggtgggac cgccgccatc      420

caggcccact acaagagcgc ccacttggac caccggcacc caggagaggg ctcccccatg      480

tcagatggga accccgagca cccctcaggc cagagccatg gcccacccac ccctccaacc      540

accccgaaga cagagctgca gtcgggcaag gcagacccga agcgggacgg gcgctccatg      600

ggggagggcg ggaagcctca catcgacttc ggcaacgtgg acattggtga gatcagccac      660

gaggtaatgt ccaacatgga gacctttgat gtggctgagt tggaccagta cctgccgccc      720

aatgggcacc caggccatgt gagcagctac tcagcagccg gctatgggct gggcagtgcc      780

ctggccgtgg ccagtggaca ctccgcctgg atctccaagc caccaggcgt ggctctgccc      840

acggtctcac cacctggtgt ggatgccaaa gcccaggtga agacagagac cgcggggccc      900

caggggcccc cacactacac cgaccagcca tccacctcac agatcgccta cacctccctc      960

agcctgcccc actatggctc agccttcccc tccatctccc gcccccagtt tgactactct     1020

gaccatcagc cctcaggacc ctattatggc cactcgggcc aggcctctgg cctctactcg     1080

gccttctcct atatggggcc ctcgcagcgg cccctctaca cggccatctc tgaccccagc     1140

ccctcagggc cccagtccca cagccccaca cactgggagc agccagtata tacgacactg     1200

tcccggccct aaagggggcc ctgtcgccac caccccccgc ccagcccctg cccccagcct     1260

gtgtgccctg ttccttgccc acctcaggcc tggtggtggc agtggaggag gctgaggagg     1320

ctgaagaggc tgacaggtcg gggggctttc tgtctggctc actgccctga tgacccaccc     1380

gccccatcca ggctccagca gcaaagcccc aggagaacag gctggacaga ggagaaggag     1440

gttgactgtt gcacccacac tgaaagatga ggggctgcac cttcccccag gaatgaccct     1500

ctatcccagg acctgagaag ggcctgctca ccctcctcgg ggaggggaag caccagggtt     1560

ggtggcatcg gaggccttac cactcctatg actcctgttt tctctctcac agatagtgag     1620

ggtctgacat gcccatgcca cctatgccac agtgcctaag ggctaggcca cccagagact     1680

gtgcccggag ctggccgtgt ctcccactca ggggctgaga gtagctttga ggagcctcat     1740

tggggagtgg ggggttcgag ggacttagtg gagttctcat cccttcaatg ccccctccct     1800

ttctgaaggc aggaaggagt tggcacagag gccccctgat ccaattctgt gccaataacc     1860

tcattctttg tctgagaaac agcccccagt cctcctccac tacaacctcc atgaccttga     1920

gacgcatccc aggaggtgac gaggcagggg ctccaggaaa ggaatcagag acaattcaca     1980

gagcctccct ccctgggctc cttgccagct ccctcttccc ttactaggct ctatggcccc     2040

tgctcagtca gccccactcc ctgggcttcc cagagagtga cagctgctca ggccctaacc     2100

cttggctcca ggagacacag ggcccagcac ccaggttgct gtcggcaggc tgaagacact     2160

agaatcctga cctgtacatt ctgcccttgc ctcttacccc ttgcctccca gtggtatttg     2220

aataaagtat gtagctatat ctgcccctat tttcctgttc tgcagccccc caaatccaca     2280

tgtaactcat tactgtctcc tgttatttat ctcagtagtc ccctctccta gccactctag     2340

cccctattaa ctctgcatta agcattccac ataataaaat taaaggttcc ggtta          2395


<210>  26
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Glu Gln Asp Leu Ser Glu Val Glu Leu Ser Pro Val Gly 
1               5                   10                  15      


Ser Glu Glu Pro Arg Cys Leu Ser Pro Gly Ser Ala Pro Ser Leu Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Gly Ser Gly Leu Arg Ala Ser Pro Gly Pro 
        35                  40                  45              


Gly Glu Leu Gly Lys Val Lys Lys Glu Gln Gln Asp Gly Glu Ala Asp 
    50                  55                  60                  


Asp Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val Leu 
65                  70                  75                  80  


Ser Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn Gly 
                85                  90                  95      


Ala Ser Lys Ser Lys Pro His Val Lys Arg Pro Met Asn Ala Phe Met 
            100                 105                 110         


Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro His 
        115                 120                 125             


Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg Leu 
    130                 135                 140                 


Leu Asn Glu Ser Asp Lys Arg Pro Phe Ile Glu Glu Ala Glu Arg Leu 
145                 150                 155                 160 


Arg Met Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro Arg 
                165                 170                 175     


Arg Arg Lys Asn Gly Lys Ala Ala Gln Gly Glu Ala Glu Cys Pro Gly 
            180                 185                 190         


Gly Glu Ala Glu Gln Gly Gly Thr Ala Ala Ile Gln Ala His Tyr Lys 
        195                 200                 205             


Ser Ala His Leu Asp His Arg His Pro Gly Glu Gly Ser Pro Met Ser 
    210                 215                 220                 


Asp Gly Asn Pro Glu His Pro Ser Gly Gln Ser His Gly Pro Pro Thr 
225                 230                 235                 240 


Pro Pro Thr Thr Pro Lys Thr Glu Leu Gln Ser Gly Lys Ala Asp Pro 
                245                 250                 255     


Lys Arg Asp Gly Arg Ser Met Gly Glu Gly Gly Lys Pro His Ile Asp 
            260                 265                 270         


Phe Gly Asn Val Asp Ile Gly Glu Ile Ser His Glu Val Met Ser Asn 
        275                 280                 285             


Met Glu Thr Phe Asp Val Ala Glu Leu Asp Gln Tyr Leu Pro Pro Asn 
    290                 295                 300                 


Gly His Pro Gly His Val Ser Ser Tyr Ser Ala Ala Gly Tyr Gly Leu 
305                 310                 315                 320 


Gly Ser Ala Leu Ala Val Ala Ser Gly His Ser Ala Trp Ile Ser Lys 
                325                 330                 335     


Pro Pro Gly Val Ala Leu Pro Thr Val Ser Pro Pro Gly Val Asp Ala 
            340                 345                 350         


Lys Ala Gln Val Lys Thr Glu Thr Ala Gly Pro Gln Gly Pro Pro His 
        355                 360                 365             


Tyr Thr Asp Gln Pro Ser Thr Ser Gln Ile Ala Tyr Thr Ser Leu Ser 
    370                 375                 380                 


Leu Pro His Tyr Gly Ser Ala Phe Pro Ser Ile Ser Arg Pro Gln Phe 
385                 390                 395                 400 


Asp Tyr Ser Asp His Gln Pro Ser Gly Pro Tyr Tyr Gly His Ser Gly 
                405                 410                 415     


Gln Ala Ser Gly Leu Tyr Ser Ala Phe Ser Tyr Met Gly Pro Ser Gln 
            420                 425                 430         


Arg Pro Leu Tyr Thr Ala Ile Ser Asp Pro Ser Pro Ser Gly Pro Gln 
        435                 440                 445             


Ser His Ser Pro Thr His Trp Glu Gln Pro Val Tyr Thr Thr Leu Ser 
    450                 455                 460                 


Arg Pro 
465     


<210>  27
<211>  2422
<212>  DNA
<213>  Homo sapiens

<400>  27
cccacgccag ggccagaggc cgaggaaggc gggctaagtg agggggcgcg gcgtggagaa       60

ccgccggggc cgggagcggt agcgagcgcc tagtaccgag cgccagggac ggcaggagtt      120

cgcggagcgc ggccgctggg ggcggacggc agagcccgcg ccacgcgatg cggggccgcc      180

gagtgtgagc tgagcccagc gggccccaag ccacctgcgg ccccctcccc tctccctgcc      240

ccccatcttt cgggggcact caaaccctct tcccctgagc tccgtggcag cccccgaaca      300

ccctcatcgc ccgctgcccc ctccccgccg ccgctaccaa ccccgaggag ggatgaccct      360

ctccggcggc ggcagcgcca gcgacatgtc cggccagacg gtgctgacgg ccgaggacgt      420

ggacatcgat gtggtgggcg agggcgacga cgggctggaa gagaaggaca gcgacgcagg      480

ttgcgatagc cccgcggggc cgccggagct gcgcctggac gaggcggacg aggtgccccc      540

ggcggcaccc catcacggac agcctcagcc gccccaccag cagcccctga cattgcccaa      600

ggaggcggcc ggagccgggg ccggaccggg gggcgacgtg ggcgcgccgg aggcggacgg      660

ctgcaagggc ggtgttggcg gcgaggaggg cggcgcgagc ggcggcgggc ctggcgcggg      720

cagcggttcg gcgggaggcc tggccccgag caagcccaag aacagcctag tgaagccgcc      780

ttactcgtac atcgcgctca tcaccatggc catcctgcag agcccgcaga agaagctgac      840

cctgagcggc atctgcgagt tcatcagcaa ccgcttcccc tactacaggg agaagttccc      900

cgcctggcag aacagcatcc gccacaacct ctcactcaac gactgcttcg tcaagatccc      960

ccgcgagccg ggcaacccgg gcaagggcaa ctactggacc ctggacccgc agtccgagga     1020

catgttcgac aacggcagct tcctgcggcg ccggaaacgc ttcaagcgcc accagcagga     1080

gcacctgcgc gagcagacgg cgctcatgat gcagagcttc ggcgcttaca gcctggcggc     1140

ggcggccggc gccgcgggac cctacggccg cccctacggc ctgcaccctg cggcggcggc     1200

cggtgcctat tcgcacccgg cagcggcggc ggccgcggct gctgcggcgg cgctccagta     1260

cccgtacgcg ctgccgccgg tggcaccggt gctgcctccc gctgtgccgc tgctgccctc     1320

gggcgagctg ggccgcaaag cggccgcctt cggctcacag ctcggcccgg gcctgcagct     1380

gcagctcaat agcctgggcg ccgccgcggc cgctgcgggc acagcgggcg ccgcgggcac     1440

caccgcgtcg ctcatcaagt ccgagccaag cgcgcggccg tcgttcagca tcgagaacat     1500

cataggtggg ggccccgcgg ctcctggggg ctcggcggtg ggcgctgggg tcgccggcgg     1560

cactgggggt tcagggggcg gcagcacggc gcagtcgttt ctgcggccac ccgggaccgt     1620

gcagtcggca gcgctcatgg ccacccacca accgctgtcg ctgagccgga cgactgccac     1680

catcgcgccc attcttagcg tgccactctc cggacagttt ctgcagcccg cagcctcggc     1740

cgccgccgct gctgcggccg ccgctcaagc caaatggccg gcgcaatagg gacgcgccaa     1800

tggccgggac ccagggtccg gcggcggcct cgagcaacaa atgcacctcc aggctgcgcg     1860

ccctgtccca agcccggtcc cggtcccgct gcccaatcct ggactctgcc tctccccaat     1920

ttcctttccc ctgagccccc aacgcctacc ttccgcggcc tccatcccct cgcgcacacc     1980

taagctggtc gagcaaactc accgcgcgcc cgccggggat agctttccat acaggtaaaa     2040

ccgaaaaccg aattttccaa aaatgcaccc cgacggcgcc tgctcttagt accgtgggga     2100

tgggagggaa attctttgta tatatttgta aaaaaattat tgactttcct tttggggttt     2160

ttattttttt aagaaaaaac aaattccgta gatttagagc tctgaacttt catttttttt     2220

gaaggttcac tctccgaagt tttatctgag aaaagaatgt atagagacgt tgggagattt     2280

taaatataaa aaattttcaa aaaggcaaaa agtgtcattc tattataaaa gtctgtttat     2340

atatgaatga atatatatgg tattctaaat gttattccat cgtgttgtac acaactttgt     2400

aaataaattt ttaaaatgcc ca                                              2422


<210>  28
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Thr Leu Ser Gly Gly Gly Ser Ala Ser Asp Met Ser Gly Gln Thr 
1               5                   10                  15      


Val Leu Thr Ala Glu Asp Val Asp Ile Asp Val Val Gly Glu Gly Asp 
            20                  25                  30          


Asp Gly Leu Glu Glu Lys Asp Ser Asp Ala Gly Cys Asp Ser Pro Ala 
        35                  40                  45              


Gly Pro Pro Glu Leu Arg Leu Asp Glu Ala Asp Glu Val Pro Pro Ala 
    50                  55                  60                  


Ala Pro His His Gly Gln Pro Gln Pro Pro His Gln Gln Pro Leu Thr 
65                  70                  75                  80  


Leu Pro Lys Glu Ala Ala Gly Ala Gly Ala Gly Pro Gly Gly Asp Val 
                85                  90                  95      


Gly Ala Pro Glu Ala Asp Gly Cys Lys Gly Gly Val Gly Gly Glu Glu 
            100                 105                 110         


Gly Gly Ala Ser Gly Gly Gly Pro Gly Ala Gly Ser Gly Ser Ala Gly 
        115                 120                 125             


Gly Leu Ala Pro Ser Lys Pro Lys Asn Ser Leu Val Lys Pro Pro Tyr 
    130                 135                 140                 


Ser Tyr Ile Ala Leu Ile Thr Met Ala Ile Leu Gln Ser Pro Gln Lys 
145                 150                 155                 160 


Lys Leu Thr Leu Ser Gly Ile Cys Glu Phe Ile Ser Asn Arg Phe Pro 
                165                 170                 175     


Tyr Tyr Arg Glu Lys Phe Pro Ala Trp Gln Asn Ser Ile Arg His Asn 
            180                 185                 190         


Leu Ser Leu Asn Asp Cys Phe Val Lys Ile Pro Arg Glu Pro Gly Asn 
        195                 200                 205             


Pro Gly Lys Gly Asn Tyr Trp Thr Leu Asp Pro Gln Ser Glu Asp Met 
    210                 215                 220                 


Phe Asp Asn Gly Ser Phe Leu Arg Arg Arg Lys Arg Phe Lys Arg His 
225                 230                 235                 240 


Gln Gln Glu His Leu Arg Glu Gln Thr Ala Leu Met Met Gln Ser Phe 
                245                 250                 255     


Gly Ala Tyr Ser Leu Ala Ala Ala Ala Gly Ala Ala Gly Pro Tyr Gly 
            260                 265                 270         


Arg Pro Tyr Gly Leu His Pro Ala Ala Ala Ala Gly Ala Tyr Ser His 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Gln Tyr Pro 
    290                 295                 300                 


Tyr Ala Leu Pro Pro Val Ala Pro Val Leu Pro Pro Ala Val Pro Leu 
305                 310                 315                 320 


Leu Pro Ser Gly Glu Leu Gly Arg Lys Ala Ala Ala Phe Gly Ser Gln 
                325                 330                 335     


Leu Gly Pro Gly Leu Gln Leu Gln Leu Asn Ser Leu Gly Ala Ala Ala 
            340                 345                 350         


Ala Ala Ala Gly Thr Ala Gly Ala Ala Gly Thr Thr Ala Ser Leu Ile 
        355                 360                 365             


Lys Ser Glu Pro Ser Ala Arg Pro Ser Phe Ser Ile Glu Asn Ile Ile 
    370                 375                 380                 


Gly Gly Gly Pro Ala Ala Pro Gly Gly Ser Ala Val Gly Ala Gly Val 
385                 390                 395                 400 


Ala Gly Gly Thr Gly Gly Ser Gly Gly Gly Ser Thr Ala Gln Ser Phe 
                405                 410                 415     


Leu Arg Pro Pro Gly Thr Val Gln Ser Ala Ala Leu Met Ala Thr His 
            420                 425                 430         


Gln Pro Leu Ser Leu Ser Arg Thr Thr Ala Thr Ile Ala Pro Ile Leu 
        435                 440                 445             


Ser Val Pro Leu Ser Gly Gln Phe Leu Gln Pro Ala Ala Ser Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Ala Ala Gln Ala Lys Trp Pro Ala Gln 
465                 470                 475             


<210>  29
<211>  2391
<212>  DNA
<213>  Homo sapiens

<400>  29
accacatcaa ccacggcatc accacgccct cgtcactgga tgccgggccc gacactgtgg       60

tcattggcat gactcgcatc cctgtcattg agaaccccca gtacttccgt cagggacaca      120

actgccacaa gccggacacg tgggtctttt caaacataga caatcatggg atattaaact      180

tgaaggacaa tagagatcat ctagtcccat caactcacta tatatatgag gaacctgagg      240

tccagagtgg ggaagtgtct tacccaaggt cacatggttt cagagaaatt atgttgaatc      300

caataagcct tcccggacat tccaagcctc ttaaccatgg catctatgtt gaggatgtca      360

atgtttattt cagcaaagga cgtcatggct tttaaaaact ccttttaagc ctccttgttt      420

tgatgtcacc ttggtaggct gggccctctg agaggttgga agctctaggc attgttctct      480

ttggatccag ggatgctaag tagaaactgc atgagccacc agtgccccgg caccctttaa      540

caccaccaga tgggtgtttt cccccatcca ccactggcag ggttgcccct tccctccaat      600

catcactgtg ctcctttttt cccggcctac gaggcagctc ctgccactat ctttagagcc      660

aataaagaga attaaaaacc tgtgcaccag gagcatcttt taaatacact agccattctc      720

ttgctttaca aaaacaacct aaccatcaca agaaagcctg atgaagtcca gccgtgctcc      780

agcctcactt tccctgcttg gaagcgtggg gtctccctgg ctctcccagg ataccatgct      840

gtcctcttag tgacctcgtc gccctgcaac ctccagtggg gaagagtcac agagagcacc      900

taagcagagg tggagacggc gcggtaagag gagggggagc caggctcaag tattggcacc      960

aagttaggtc tcagaggaaa gaatggaaac caatcacttt acatttttat ttttattttc     1020

ggtggaaaaa tcatcctttt ttgggacata cttgccccct acttcctctt ctctctggaa     1080

cggctcacaa tgagtgtgac attagaaaac tccttgcaga ggagagtttc tccaggctct     1140

tcctgggccc ttagatctgc agttccgaca agctttggct gcaggaggtt ttacccatga     1200

actggccatc ctactaggac cacaagggac caagggaatc agggacaaag gcccttcctg     1260

ccagcccatg atcccgggat tggctctctt cccctacttc cacttattct tgactctgag     1320

aacttttgga acccaatgga atcagcattt caaggtcaag atgaactgaa ggggaagaga     1380

agtaaaactt ggcctcctcc agcccctctc atggcaccaa tggaagtgtc ctcctgttct     1440

ctggtcaata tgtgtgttta ctttgcttgc tttgactcat gccttactcc atggccaccc     1500

tctcccaaag agggggctcg cttcccccat tttcaacttg atccactgag gagagggaag     1560

ggggtgactt tcccttcttc agtaggaaag gcacatttgt agggcctgaa actctcccgt     1620

atttgctgac tcattggtgg agtagacttc tggctcccag ctccactggc ccatggggcc     1680

tccattgtat gaagtcagca taggctgccc acctaatggt ggagagcatg aaactgggag     1740

catcctgtgg ggggcttgtg ggggaaaaag gtggttgttt taacccaccg ttgttttggg     1800

gtggtgttgc acactagtag agaatagagt ctatgccttt ggcaaattta actgggagtt     1860

tggattccca cttaagggtt ttacttcttg ggtcctgtgg atggtggttc ttcgtgtcag     1920

gatcccagcc cgattctgca aatgcctcca tggggtttaa aaacatgagg ctttccaagt     1980

tcttgcccag tatctggggc agcctccaga gtatcacctg ggagttcagg ttctctccag     2040

ggctccaggt gtgtgtttat ctcgccccct ccagctctcc tcatcctgct ccccattgct     2100

ccatgtcagg ctgttcccca ttgtgccctg ctgatgcttt gggtccaggg cctcctccca     2160

agtgtggctt taaggagtaa gcttgaggat gatgtttttt aattattgta aatcattacc     2220

tcatttccag cctcccaggc tccatccatc ccagcatctt ttattctgcc attttcctca     2280

ccttgtgcta tgacaatggg gcgttgtgtt tccacagaga cttataggag tgttcagtgt     2340

atagtttctt aataaacact ttattttcta atgaaaaaaa aaaaaaaaaa a              2391


<210>  30
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Trp Val Phe Ser Asn Ile Asp Asn His Gly Ile Leu Asn Leu Lys Asp 
    530                 535                 540                 


Asn Arg Asp His Leu Val Pro Ser Thr His Tyr Ile Tyr Glu Glu Pro 
545                 550                 555                 560 


Glu Val Gln Ser Gly Glu Val Ser Tyr Pro Arg Ser His Gly Phe Arg 
                565                 570                 575     


Glu Ile Met Leu Asn Pro Ile Ser Leu Pro Gly His Ser Lys Pro Leu 
            580                 585                 590         


Asn His Gly Ile Tyr Val Glu Asp Val Asn Val Tyr Phe Ser Lys Gly 
        595                 600                 605             


Arg His Gly Phe 
    610         


<210>  31
<211>  2435
<212>  DNA
<213>  Homo sapiens

<400>  31
ccgcagttcc ttacaaactc ttcacggacc acggcggcct caacgagaag cgcaagcagc       60

ggcgcatccg caccactttc accagtgccc agctcaaaga gctggaaagg gtcttcgcgg      120

agactcacta ccccgacatc tacactcggg aggagctggc cctgaagatc gacctcacag      180

aggcgcgagt ccaggtgtgg ttccagaacc gccgcgccaa gtttcgcaag caggagcgcg      240

cagcggcagc cgcagcggcc gcggccaaga acggctcctc gggcaaaaag tctgactctt      300

ccagggacga cgagagcaaa gaggccaaga gcactgaccc ggacagcact gggggcccag      360

gtcccaatcc caaccccacc cccagctgcg gggcgaatgg aggcggcggc ggcgggccca      420

gcccggctgg agctccgggg gcggcggggc ccgggggccc gggaggcgaa cccggcaagg      480

gcggcgcagc agcagcggcg gcggccgcgg cagcggcggc ggcggcagcg gcagcggcgg      540

cagctggagg cctggctgcg gctgggggcc ctggacaagg ctgggctccc ggccccggcc      600

ccatcacctc catcccggat tcgcttgggg gtcccttcgc cagcgtccta tcttcgctcc      660

aaagacccaa cggtgccaaa gccgccttag tgaagagcag tatgttctga tctggaatcc      720

tgcggcggcg gcggcggcgg cgacagcggg cgagccaggg cccgggcggg cgagtgggcg      780

agcgggtagg cccaaggcta ttgtcgtcgc tgctgccatg gctttttcat tgagggccta      840

aagtaatcgc gctaagaata aagggaaaac ggcgtcgccc tcatttcaac cccactccta      900

cccccttcct caacccccaa acaaaacaaa caaacttccc tggcttcgca cctgcctggg      960

gcctcgcagc ggggccaggg ctccgcctgc tgatcggggg ttgtgagcag cgcggcctgg     1020

acgcggggca ctctcagggg gctgtgtctg cgtgtcagtt tgtgtctgtc tcggggaatg     1080

tgtgtctgtg gcccaagcag gtgacaggaa gagatggggg gcctcaacca acttagtgac     1140

ttgtttagaa aaaaaagaca aaaaagtaaa aataaaaaca aaaaagttgg aaggcagaaa     1200

ccattaaaaa acaaaaagcc aacaacccag aaaggtttaa aaaacataag gaaaaaaaag     1260

acaaattaaa ggaggggcta ggggagaagc tgcagctgga gctgaaggct cgatcttgtg     1320

aacccctaaa tccgctccct cctaacagca cggattctct tggggctctt cttcagggaa     1380

gagtagggac gccgttccag ccccccttcc tatcgtgtcc ttgggttcgg gtcactgcgg     1440

cgacgacttg ctcagactgt cccggcggcc ggagtgactt tctcgcaccc ccttgcctgt     1500

cccacctcgc tgaacaccat cccgccatta gcgcatcgga accccacaca gttgcaactc     1560

ccaaccccga atctttgcag ccgttcggcc ctgaaagatg ccctatccat gagatgcctt     1620

ttcatctgca aactctgcaa aatgtgtctc atgtttcgca actctttttt tccccctcgc     1680

tcccgcctac cccgtcggca ttttcttctt ccaccagctt ttactgaact ttttggcact     1740

gctttggatt ggggtcaatt gcagtccacg taactggctg cagagaaatc taccgagcaa     1800

ggaaaaggca cacacacacg tttgcagggg tgtctcggtt tgcatttctg ttggaatgat     1860

ccgaactgga ctcacatcct gtatggtgga tggactgtat attgagggtt ccattcttcg     1920

cgcagtttag acatctctgt tttgattctt tgttgttgtt tttattttaa aaggcacaaa     1980

ctctagatat tagttgaatg ttgaggcttt aactttttcg gtgtctttct acaactgtgt     2040

tctgtgactc aattgtatcg tgttaatatc agtgcagact gtctcctcta cgtgaccgta     2100

taatgttttt ctcttcttgt agtctctatg gcgtgtcttt atggtgtaat aaggttctca     2160

cgggttcaat cttttgtgtt tagagaggcc acggttcaga caatggtata tatttttgtt     2220

atcaggtgca tgtctgtctg atttcttttt ttttcctgtt ggactatgtt tgtgaacata     2280

attgtcataa gttatgtttc agatttttga atttatttat atgtgttata atgaatgctt     2340

ctatttaaaa gggaaatatt tctacatgtg catatagttt tccaagagtg taccattaac     2400

ttgattgttg ataataaaaa caaaaagcaa gtcta                                2435


<210>  32
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Tyr Lys Met Glu Tyr Ser Tyr Leu Asn Ser Ser Ala Tyr Glu Ser 
1               5                   10                  15      


Cys Met Ala Gly Met Asp Thr Ser Ser Leu Ala Ser Ala Tyr Ala Asp 
            20                  25                  30          


Phe Ser Ser Cys Ser Gln Ala Ser Gly Phe Gln Tyr Asn Pro Ile Arg 
        35                  40                  45              


Thr Thr Phe Gly Ala Thr Ser Gly Cys Pro Ser Leu Thr Pro Gly Ser 
    50                  55                  60                  


Cys Ser Leu Gly Thr Leu Arg Asp His Gln Ser Ser Pro Tyr Ala Ala 
65                  70                  75                  80  


Val Pro Tyr Lys Leu Phe Thr Asp His Gly Gly Leu Asn Glu Lys Arg 
                85                  90                  95      


Lys Gln Arg Arg Ile Arg Thr Thr Phe Thr Ser Ala Gln Leu Lys Glu 
            100                 105                 110         


Leu Glu Arg Val Phe Ala Glu Thr His Tyr Pro Asp Ile Tyr Thr Arg 
        115                 120                 125             


Glu Glu Leu Ala Leu Lys Ile Asp Leu Thr Glu Ala Arg Val Gln Val 
    130                 135                 140                 


Trp Phe Gln Asn Arg Arg Ala Lys Phe Arg Lys Gln Glu Arg Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Ala Ala Ala Lys Asn Gly Ser Ser Gly Lys Lys Ser 
                165                 170                 175     


Asp Ser Ser Arg Asp Asp Glu Ser Lys Glu Ala Lys Ser Thr Asp Pro 
            180                 185                 190         


Asp Ser Thr Gly Gly Pro Gly Pro Asn Pro Asn Pro Thr Pro Ser Cys 
        195                 200                 205             


Gly Ala Asn Gly Gly Gly Gly Gly Gly Pro Ser Pro Ala Gly Ala Pro 
    210                 215                 220                 


Gly Ala Ala Gly Pro Gly Gly Pro Gly Gly Glu Pro Gly Lys Gly Gly 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Gly Gly Leu Ala Ala Ala Gly Gly Pro Gly Gln Gly 
            260                 265                 270         


Trp Ala Pro Gly Pro Gly Pro Ile Thr Ser Ile Pro Asp Ser Leu Gly 
        275                 280                 285             


Gly Pro Phe Ala Ser Val Leu Ser Ser Leu Gln Arg Pro Asn Gly Ala 
    290                 295                 300                 


Lys Ala Ala Leu Val Lys Ser Ser Met Phe 
305                 310                 


<210>  33
<211>  2411
<212>  DNA
<213>  Homo sapiens

<400>  33
gaaagaagga aatcagaaag gaagggagtt aacaaaataa taaaaacagc ctgagccacg       60

gctggagaga ccgagacccg gcgcaagaga gcgcagcctt agtaggagag gaacgcgaga      120

cgcggcagag cgcgttcagc actgactttt gctgctgctt ctgctttttt ttttcttaga      180

aacaagaagg cgccagcggc agcctcacac gcgagcgcca cgcgaggctc ccgaagccaa      240

cccgcgaagg gaggagggga gggaggagga ggcggcgtgc agggaggaga aaaagcattt      300

tcactttttt tgctcccact ctaagaagtc tcccggggat tttgtatata ttttttaact      360

tccgtcaggg ctcccgcttc atatttcctt ttctttccct ctctgttcct gcacccaagt      420

tctctctgtg tccccctcgc gggccccgca cctcgcgtcc cggatcgctc tgattccgcg      480

actccttggc cgccgctgcg catggaaagc tctgccaaga tggagagcgg cggcgccggc      540

cagcagcccc agccgcagcc ccagcagccc ttcctgccgc ccgcagcctg tttctttgcc      600

acggccgcag ccgcggcggc cgcagccgcc gcagcggcag cgcagagcgc gcagcagcag      660

cagcagcagc agcagcagca gcagcaggcg ccgcagctga gaccggcggc cgacggccag      720

ccctcagggg gcggtcacaa gtcagcgccc aagcaagtca agcgacagcg ctcgtcttcg      780

cccgaactga tgcgctgcaa acgccggctc aacttcagcg gctttggcta cagcctgccg      840

cagcagcagc cggccgccgt ggcgcgccgc aacgagcgcg agcgcaaccg cgtcaagttg      900

gtcaacctgg gctttgccac ccttcgggag cacgtcccca acggcgcggc caacaagaag      960

atgagtaagg tggagacact gcgctcggcg gtcgagtaca tccgcgcgct gcagcagctg     1020

ctggacgagc atgacgcggt gagcgccgcc ttccaggcag gcgtcctgtc gcccaccatc     1080

tcccccaact actccaacga cttgaactcc atggccggct cgccggtctc atcctactcg     1140

tcggacgagg gctcttacga cccgctcagc cccgaggagc aggagcttct cgacttcacc     1200

aactggttct gaggggctcg gcctggtcag gccctggtgc gaatggactt tggaagcagg     1260

gtgatcgcac aacctgcatc tttagtgctt tcttgtcagt ggcgttggga gggggagaaa     1320

aggaaaagaa aaaaaaaaga agaagaagaa gaaaagagaa gaagaaaaaa acgaaaacag     1380

tcaaccaacc ccatcgccaa ctaagcgagg catgcctgag agacatggct ttcagaaaac     1440

gggaagcgct cagaacagta tctttgcact ccaatcattc acggagatat gaagagcaac     1500

tgggacctga gtcaatgcgc aaaatgcagc ttgtgtgcaa aagcagtggg ctcctggcag     1560

aagggagcag cacacgcgtt atagtaactc ccatcacctc taacacgcac agctgaaagt     1620

tcttgctcgg gtcccttcac ctcctcgccc tttcttaaag tgcagttctt agccctctag     1680

aaacgagttg gtgtctttcg tctcagtagc ccccacccca ataagctgta gacattggtt     1740

tacagtgaaa ctatgctatt ctcagccctt tgaaactctg cttctcctcc agggcccgat     1800

tcccaaaccc catggcttcc ctcacactgt cttttctacc attttcatta tagaatgctt     1860

ccaatctttt gtgaattttt tattataaaa aatctatttg tatctatcct aaccagttcg     1920

gggatatatt aagatatttt tgtacataag agagaaagag agagaaaaat ttatagaagt     1980

tttgtacaaa tggtttaaaa tgtgtatatc ttgatacttt aacatgtaat gctattacct     2040

ctgcatattt tagatgtgta gttcacctta caactgcaat tttccctatg tggttttgta     2100

aagaactctc ctcataggtg agatcaagag gccaccagtt gtacttcagc accaatgtgt     2160

cttactttat agaaatgttg ttaatgtatt aatgatgtta ttaaatactg ttcaagaaga     2220

acaaagttta tgcagctact gtccaaactc aaagtggcag ccagttggtt ttgataggtt     2280

gccttttgga gatttctatt actgcctttt tttttcttac tgttttatta caaacttaca     2340

aaaatatgta taaccctgtt ttatacaaac tagtttcgta ataaaacttt ttcctttttt     2400

taaaatgaaa a                                                          2411


<210>  34
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  35
<211>  2384
<212>  DNA
<213>  Homo sapiens

<400>  35
ctttctaaaa agagatttat ttttaaatca atgggactct gatataaagg aagaataagt       60

cactgtaaaa cagaactttt aaatgaagct taaattactc aatttaaaat tttaaaatcc      120

tttaaaacaa cttttcaatt aatattatca cactattatc agattgtaat tagatgcaaa      180

tgagagagca gtttagttgt tgcatttttc ggacactgga aacatttaaa tgatcaggag      240

ggagtaacag aaagagcaag gctgtttttg aaaatcatta cactttcact agaagcccaa      300

acctcagcat tctgcaatat gtaaccaaca tgtcacaaac aagcagcatg taacagactg      360

gcacatgtgc cagctgaatt taaaatataa tacttttaaa aagaaaatta ttacatcctt      420

tacattcagt taagatcaaa cctcacaaag agaaatagaa tgtttgaaag gctatcccaa      480

aagacttttt tgaatctgtc attcacatac cctgtgaaga caatactatc tacaattttt      540

tcaggattat taaaatcttc ttctttcact atcgtagctt aaactctgtt tggttttgtc      600

atctgtaaat acttacctac atacactgca tgtagatgat taaatgaggg caggccctgt      660

gctcatagct ttacgatgga gagatgccag tgacctcata ataaagactg tgaactgcct      720

ggtgcagtgt ccacatgaca aaggggcagg tagcaccctc tctcacccat gctgtggtta      780

aaatggtttc tagcatatgt ataatgctat agttaaaata ctatttttca aaatcataca      840

gattagtaca tttaacagct acctgtaaag cttattacta atttttgtat tatttttgta      900

aatagccaat agaaaagttt gcttgacatg gtgcttttct ttcatctaga ggcaaaactg      960

ctttttgaga ccgtaagaac ctcttagctt tgtgcgttcc tgcctaattt ttatatcttc     1020

taagcaaagt gccttaggat agcttgggat gagatgtgtg tgaaagtatg tacaagagaa     1080

aacggaagag agaggaaatg aggtggggtt ggaggaaacc catggggaca gattcccatt     1140

cttagcctaa cgttcgtcat tgcctcgtca catcaatgca aaaggtcctg attttgttcc     1200

agcaaaacac agtgcaatgt tctcagagtg actttcgaaa taaattgggc ccaagagctt     1260

taactcggtc ttaaaatatg cccaaatttt tactttgttt ttcttttaat aggctgggcc     1320

acatgttgga aataagctag taatgttgtt ttctgtcaat attgaatgtg atggtacagt     1380

aaaccaaaac ccaacaatgt ggccagaaag aaagagcaat aataattaat tcacacacca     1440

tatggattct atttataaat cacccacaaa cttgttcttt aatttcatcc caatcacttt     1500

ttcagaggcc tgttatcata gaagtcattt tagactctca attttaaatt aattttgaat     1560

cactaatatt ttcacagttt attaatatat ttaatttcta tttaaatttt agattatttt     1620

tattaccatg tactgaattt ttacatcctg ataccttttc cttctccatg tcagtatcat     1680

gttctctaat tatcttgcca aattttgaaa ctacacacaa aaagcatact tgcattattt     1740

ataataaaat tgcattcagt ggctttttaa aaaaatgttt gattcaaaac tttaacatac     1800

tgataagtaa gaaacaatta taatttcttt acatactcaa aaccaagata gaaaaaggtg     1860

ctatcgttca acttcaaaac atgtttccta gtattaagga ctttaatata gcaacagaca     1920

aaattattgt taacatggat gttacagctc aaaagattta taaaagattt taacctattt     1980

tctcccttat tatccactgc taatgtggat gtatgttcaa acacctttta gtattgatag     2040

cttacatatg gccaaaggaa tacagtttat agcaaaacat gggtatgctg tagctaactt     2100

tataaaagtg taatataaca atgtaaaaaa ttatatatct gggaggattt tttggttgcc     2160

taaagtggct atagttactg attttttatt atgtaagcaa aaccaataaa aatttaagtt     2220

tttttaacaa ctaccttatt tttcactgta cagacactaa ttcattaaat actaattgat     2280

tgtttaaaag aaatataaat gtgacaagtg gacattattt atgttaaata tacaattatc     2340

aagcaagtat gaagttattc aattaaaatg ccacatttct ggtc                      2384


<210>  36
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  37
<211>  2414
<212>  DNA
<213>  Homo sapiens

<400>  37
tccacctgct ctcccagcac caagacctgc cccgacggcc actgcgatgt tgtggagacc       60

caagacatca acatttgccc tcaggactgc ctccggggca gcattgttgg gggacacgag      120

cctggggagc cccgggggat taaagctggc tatggcacct gcaactgctt ccctgaggag      180

gagaagtgct tctgcgagcc cgaagacatc caggatccac tgtgcgacga gctgtgccgc      240

acggtgatcg cagccgctgt cctcttctcc ttcatcgtct cggtgctgct gtctgccttc      300

tgcatccact gctaccacaa gtttgcccac aagccaccca tctcctcagc tgagatgacc      360

ttccggaggc ccgcccaggc cttcccggtc agctactcct cttccggtgc ccgccggccc      420

tcgctggact ccatggagaa ccaggtctcc gtggatgcct tcaagatcct ggaggatcca      480

aagtgggaat tccctcggaa gaacttggtt cttggaaaaa ctctaggaga aggcgaattt      540

ggaaaagtgg tcaaggcaac ggccttccat ctgaaaggca gagcagggta caccacggtg      600

gccgtgaaga tgctgaaaga gaacgcctcc ccgagtgagc tgcgagacct gctgtcagag      660

ttcaacgtcc tgaagcaggt caaccaccca catgtcatca aattgtatgg ggcctgcagc      720

caggatggcc cgctcctcct catcgtggag tacgccaaat acggctccct gcggggcttc      780

ctccgcgaga gccgcaaagt ggggcctggc tacctgggca gtggaggcag ccgcaactcc      840

agctccctgg accacccgga tgagcgggcc ctcaccatgg gcgacctcat ctcatttgcc      900

tggcagatct cacaggggat gcagtatctg gccgagatga agctcgttca tcgggacttg      960

gcagccagaa acatcctggt agctgagggg cggaagatga agatttcgga tttcggcttg     1020

tcccgagatg tttatgaaga ggattcctac gtgaagagga gccagggtcg gattccagtt     1080

aaatggatgg caattgaatc cctttttgat catatctaca ccacgcaaag tgatgtatgg     1140

tcttttggtg tcctgctgtg ggagatcgtg accctagggg gaaaccccta tcctgggatt     1200

cctcctgagc ggctcttcaa ccttctgaag accggccacc ggatggagag gccagacaac     1260

tgcagcgagg agatgtaccg cctgatgctg caatgctgga agcaggagcc ggacaaaagg     1320

ccggtgtttg cggacatcag caaagacctg gagaagatga tggttaagag gagagactac     1380

ttggaccttg cggcgtccac tccatctgac tccctgattt atgacgacgg cctctcagag     1440

gaggagacac cgctggtgga ctgtaataat gcccccctcc ctcgagccct cccttccaca     1500

tggattgaaa acaaactcta tggtagaatt tcccatgcat ttactagatt ctagcaccgc     1560

tgtccccttt gcactatcct tcctctctgt gatgcttttt aaaaatgttt ctggtctgaa     1620

caaaaccaaa gtctgctctg aaccttttta tttgtaaatg tctgactttg catccagttt     1680

acatttaggc attattgcaa ctatgttttt ctaaaaggat gtgaaaataa gtgtaattac     1740

cacattgccc agcaacttag gatggtagag gaaaaaacag atcagggcgg aactctcagg     1800

ggagaccaag aacaggttga ataaggcgct tctggggtgg gaatcaagtc atagtacttc     1860

tactttaact aagtggataa atatacaaat ctggggaggt attcagttga gaaaggagcc     1920

accagcacca ctcagcctgc actgggagca cagccaggtt cccccagacc cctcctgggc     1980

aggcaggtgc ctctcagagg ccacccggca ctggcgagca gccactggcc aagcctcagc     2040

cccagtccca gccacatgtc ctccatcagg ggtagcgagg ttgcaggagc tggctggccc     2100

tgggaggacg cacccccact gctgttttca catcctttcc cttacccacc ttcaggacgg     2160

ttgtcactta tgaagtcagt gctaaagctg gagcagttgc tttttgaaag aacatggtct     2220

gtggtgctgt ggtcttacaa tggacagtaa atatggttct tgccaaaact ccttcttttg     2280

tctttgatta aatactagaa attttttctg tttcctaact tcatcattga ttgtttgaaa     2340

tcttggagtt tcaagcattt ttttcaagct gagacggttc cttttgcatg cctcctgact     2400

cactgactcc tcac                                                       2414


<210>  38
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Val Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro 
1               5                   10                  15      


Thr Phe Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys 
            20                  25                  30          


Arg Lys Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp 
        35                  40                  45              


Val Val Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu 
    50                  55                  60                  


Leu Pro Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp 
65                  70                  75                  80  


Pro Asn Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr 
                85                  90                  95      


Val His Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu 
            100                 105                 110         


Asn Arg Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln 
        115                 120                 125             


Gly Pro Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu 
    130                 135                 140                 


Pro Val Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg 
145                 150                 155                 160 


Arg Ala Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys 
                165                 170                 175     


Gln Ala Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly 
            180                 185                 190         


Ala Asn Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser 
        195                 200                 205             


Gly Ile Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys 
    210                 215                 220                 


Ala Glu Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg 
225                 230                 235                 240 


Gln Ala Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala 
                245                 250                 255     


Glu Glu Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu 
            260                 265                 270         


Glu Cys Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu 
        275                 280                 285             


Trp Arg Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys 
    290                 295                 300                 


Ser Pro Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu 
305                 310                 315                 320 


Thr Gln Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile 
                325                 330                 335     


Val Gly Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr 
            340                 345                 350         


Gly Thr Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro 
        355                 360                 365             


Glu Asp Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile 
    370                 375                 380                 


Ala Ala Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala 
385                 390                 395                 400 


Phe Cys Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser 
                405                 410                 415     


Ser Ala Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser 
            420                 425                 430         


Tyr Ser Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn 
        435                 440                 445             


Gln Val Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu 
    450                 455                 460                 


Phe Pro Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu 
465                 470                 475                 480 


Phe Gly Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala 
                485                 490                 495     


Gly Tyr Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro 
            500                 505                 510         


Ser Glu Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val 
        515                 520                 525             


Asn His Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly 
    530                 535                 540                 


Pro Leu Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly 
545                 550                 555                 560 


Phe Leu Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly 
                565                 570                 575     


Gly Ser Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu 
            580                 585                 590         


Thr Met Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met 
        595                 600                 605             


Gln Tyr Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg 
    610                 615                 620                 


Asn Ile Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly 
625                 630                 635                 640 


Leu Ser Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln 
                645                 650                 655     


Gly Arg Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His 
            660                 665                 670         


Ile Tyr Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp 
        675                 680                 685             


Glu Ile Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu 
    690                 695                 700                 


Arg Leu Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp 
705                 710                 715                 720 


Asn Cys Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln 
                725                 730                 735     


Glu Pro Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu 
            740                 745                 750         


Lys Met Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr 
        755                 760                 765             


Pro Ser Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr 
    770                 775                 780                 


Pro Leu Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser 
785                 790                 795                 800 


Thr Trp Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala Phe Thr 
                805                 810                 815     


Arg Phe 
        


<210>  39
<211>  1910
<212>  DNA
<213>  Homo sapiens

<400>  39
accagacccc tctgaggatg gagcaggagc tggctgccct gaggctgcaa aacttcttcc       60

ctcgtggaga cagggaggca cctcagacac tcaccccgga ctcccttgaa cagggacagg      120

gaggaacccc aggcagctag accccagcag cagccacacg agcacactgt ggggcaggga      180

ggggcatctc ttgagaacaa aagatccatt tctcgacttt ccaaactgga gagcttcttg      240

agagaaaaga gagagacagg tacaggtcca cgccacccac acacagccct gtgcacacag      300

accggacaca ggcgtccaca gttctgggaa gtcatcagtg atgagcatgg catcgacccc      360

agcggcaact acgtgggcga ctcggacttg cagctggagc ggatcagcgt ctactacaac      420

gaggcctctt ctcacaagta cgtgcctcga gccattctgg tggacctgga acccggaacc      480

atggacagtg tccgctcagg ggcctttgga catctcttca ggcctgacaa tttcatcttt      540

ggtcagagtg gggccggcaa caactgggcc aagggtcact acacggaggg ggcggagctg      600

gtggattcgg tcctggatgt ggtgcggaag gagtgtgaaa actgcgactg cctgcagggc      660

ttccagctga cccactcgct ggggggcggc acgggctccg gcatgggcac gttgctcatc      720

agcaaggtgc gtgaggagta tcccgaccgc atcatgaaca ccttcagcgt cgtgccctca      780

cccaaggtgt cagacacggt ggtggagccc tacaacgcca cgctgtccat ccaccagctg      840

gtggagaaca cggatgagac ctactgcatc gacaacgagg cgctctacga catctgcttc      900

cgcaccctca agctggccac gcccacctac ggggacctca accacctggt atcggccacc      960

atgagcggag tcaccacctc cttgcgcttc ccgggccagc tcaacgctga cctgcgcaag     1020

ctggccgtca acatggtgcc cttcccgcgc ctgcacttct tcatgcccgg cttcgccccc     1080

ctcacagccc ggggcagcca gcagtaccgg gccctgaccg tgcccgagct cacccagcag     1140

atgttcgatg ccaagaacat gatggccgcc tgcgacccgc gccacggccg ctacctgacg     1200

gtggccaccg tgttccgggg ccgcatgtcc atgaaggagg tggacgagca gatgctggcc     1260

atccagagca agaacagcag ctacttcgtg gagtggatcc ccaacaacgt gaaggtggcc     1320

gtgtgtgaca tcccgccccg cggcctcaag atgtcctcca ccttcatcgg gaacagcacg     1380

gccatccagg agctgttcaa gcgcatctcc gagcagttca cggccatgtt ccggcgcaag     1440

gccttcctgc actggtacac gggcgagggc atggacgaga tggagttcac cgaggccgag     1500

agcaacatga acgacctggt gtccgagtac cagcagtacc aggacgccac ggccgaggaa     1560

gagggcgaga tgtacgaaga cgacgaggag gagtcggagg cccagggccc caagtgaagc     1620

tgctcgcagc tggagtgaga ggcaggtggc ggccggggcc gaagccagca gtgtctaaac     1680

ccccggagcc atcttgctgc cgacaccctg ctttcccctc gccctagggc tcccttgccg     1740

ccctcctgca gtatttatgg cctcgtcctc cccacctagg ccacgtgtga gctgctcctg     1800

tctctgtctt attgcagctc caggcctgac gttttacggt tttgtttttt actggtttgt     1860

gtttatattt tcggggatac ttaataaatc tattgctgtc agataccctt                1910


<210>  40
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asp Ser Val Arg Ser Gly Ala Phe Gly His Leu Phe Arg Pro Asp 
1               5                   10                  15      


Asn Phe Ile Phe Gly Gln Ser Gly Ala Gly Asn Asn Trp Ala Lys Gly 
            20                  25                  30          


His Tyr Thr Glu Gly Ala Glu Leu Val Asp Ser Val Leu Asp Val Val 
        35                  40                  45              


Arg Lys Glu Cys Glu Asn Cys Asp Cys Leu Gln Gly Phe Gln Leu Thr 
    50                  55                  60                  


His Ser Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Ile 
65                  70                  75                  80  


Ser Lys Val Arg Glu Glu Tyr Pro Asp Arg Ile Met Asn Thr Phe Ser 
                85                  90                  95      


Val Val Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn 
            100                 105                 110         


Ala Thr Leu Ser Ile His Gln Leu Val Glu Asn Thr Asp Glu Thr Tyr 
        115                 120                 125             


Cys Ile Asp Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys 
    130                 135                 140                 


Leu Ala Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Ala Thr 
145                 150                 155                 160 


Met Ser Gly Val Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala 
                165                 170                 175     


Asp Leu Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His 
            180                 185                 190         


Phe Phe Met Pro Gly Phe Ala Pro Leu Thr Ala Arg Gly Ser Gln Gln 
        195                 200                 205             


Tyr Arg Ala Leu Thr Val Pro Glu Leu Thr Gln Gln Met Phe Asp Ala 
    210                 215                 220                 


Lys Asn Met Met Ala Ala Cys Asp Pro Arg His Gly Arg Tyr Leu Thr 
225                 230                 235                 240 


Val Ala Thr Val Phe Arg Gly Arg Met Ser Met Lys Glu Val Asp Glu 
                245                 250                 255     


Gln Met Leu Ala Ile Gln Ser Lys Asn Ser Ser Tyr Phe Val Glu Trp 
            260                 265                 270         


Ile Pro Asn Asn Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly 
        275                 280                 285             


Leu Lys Met Ser Ser Thr Phe Ile Gly Asn Ser Thr Ala Ile Gln Glu 
    290                 295                 300                 


Leu Phe Lys Arg Ile Ser Glu Gln Phe Thr Ala Met Phe Arg Arg Lys 
305                 310                 315                 320 


Ala Phe Leu His Trp Tyr Thr Gly Glu Gly Met Asp Glu Met Glu Phe 
                325                 330                 335     


Thr Glu Ala Glu Ser Asn Met Asn Asp Leu Val Ser Glu Tyr Gln Gln 
            340                 345                 350         


Tyr Gln Asp Ala Thr Ala Glu Glu Glu Gly Glu Met Tyr Glu Asp Asp 
        355                 360                 365             


Glu Glu Glu Ser Glu Ala Gln Gly Pro Lys 
    370                 375             


<210>  41
<211>  2388
<212>  DNA
<213>  Homo sapiens

<400>  41
ttgcccgagt tcctccggga agcgctccgg gtagattctg ggggccggga gctgagatcc       60

ctgggcgggg agctggggaa gggatggggc tgaggacagc gaagaagagg gggcttgggg      120

gaggggggaa atggaagaga gaggagggag gaggtacaag aggaaggaga gaagtgcggc      180

cagcttgctt tctccagtcg ggtggccgcg gggacccggg cgacgtcgga ggccctgccg      240

ggaacccagg ctgcagcccc cacccccgcg ctgcgacacg ccccccaccc cttccggctc      300

acacccccgc ccacactcct gagtggtgcg gtgcagcgtc ggccgaggca gcagagccga      360

ggagagcagg tccacacctc tgcatccctg caccaggact caccaagacg cccatcctgg      420

aaaaggtccc ccgtaagatg gcagcaaaaa ctcccagcag tgaggagtct gggctgccca      480

aactgcccgt gcccccgctg cagcagaccc tggccacgta cctgcagtgc atgcgacact      540

tggtgtctga ggagcagttc aggaagagcc aggccattgt gcagcagttt ggggcccctg      600

gtggcctcgg cgagaccctg cagcagaaac tcctggagcg gcaggagaag acagccaact      660

gggtgtctga gtactggctg aatgacatgt atctcaacaa ccgcctggcc ctgcctgtca      720

actccagccc tgccgtgatc tttgctcggc agcacttccc tggcaccgat gaccagctga      780

ggtttgcagc cagcctcatc tctggtgtac tcagctacaa ggccctgctg gacagccact      840

ccattcccac tgactgtgcc aaaggccagc tgtcagggca gcccctttgc atgaagcaat      900

actatgggct cttctcctcc taccggctcc ccggccatac ccaggacacg ctggtggctc      960

agaacagcag catcatgccg gagcctgagc acgtcatcgt agcctgctgc aatcagttct     1020

ttgtcttgga tgttgtcatt aatttccgcc gtctcagtga gggggatctg ttcactcagt     1080

tgagaaagat agtcaaaatg gcttccaacg aggacgagcg tttgcctcca attggcctgc     1140

tgacgtctga cgggaggagc gagtgggccg aggccaggac ggtcctcgtg aaagactcca     1200

ccaaccggga ctcgctggac atgattgagc gctgcatctg ccttgtatgc ctggacgcgc     1260

caggaggcgt ggagctcagc gacacccaca gggcactcca gctccttcac ggcggaggct     1320

acagcaagaa cggggccaat cgctggtacg acaagtccct gcagtttgtg gtgggccgag     1380

acggcacctg cggtgtggtg tgcgaacact ccccattcga tggcatcgtc ctggtgcagt     1440

gcactgagca tctgctcaag cacatgacgc agagcagcag gaagctgatc cgagcagact     1500

ccgtcagcga gctccccgcc ccccggaggc tgcggtggaa atgctccccg gaaattcaag     1560

gccacttagc ctcctcggca gaaaaacttc aacgaatagt aaagaacctt gacttcattg     1620

tctataagtt tgacaactat gggaaaacat tcattaagaa gcagaaatgc agccctgatg     1680

ccttcatcca ggtggccctc cagctggcct tctacaggct ccatcgaaga ctggtgccca     1740

cctacgagag cgcgtccatc cgccgattcc aggagggacg cgtggacaac atcagatcgg     1800

ccactccaga ggcactggct tttgtgagag ccgtgactga ccacaaggct gctgtgccag     1860

cttctgagaa gcttctgctc ctgaaggatg ccatccgtgc ccagactgca tacacagtca     1920

tggccataac agggatggcc attgacaacc acctgctggc actgcgggag ctggcccggg     1980

ccatgtgcaa ggagctgccc gagatgttca tggatgaaac ctacctgatg agcaaccggt     2040

ttgtcctctc cactagccag gtgcccacaa ccacggagat gttctgctgc tatggtcctg     2100

tggtcccaaa tgggtatggt gcctgctaca acccccagcc agagaccatc cttttctgca     2160

tctctagctt tcacagctgc aaagagactt cttctagcaa gtttgcaaaa gctgtggaag     2220

aaagcctcat tgacatgaga gacctctgca gtctgctgcc gcctactgag agcaagccat     2280

tggcaacaaa ggaaaaagcc acgaggccca gccagggaca ccaaccttga ctcctgccac     2340

taggtttcac ctcccaaacc cagcctctag aacagccaga ccctgcag                  2388


<210>  42
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ala Lys Thr Pro Ser Ser Glu Glu Ser Gly Leu Pro Lys Leu 
1               5                   10                  15      


Pro Val Pro Pro Leu Gln Gln Thr Leu Ala Thr Tyr Leu Gln Cys Met 
            20                  25                  30          


Arg His Leu Val Ser Glu Glu Gln Phe Arg Lys Ser Gln Ala Ile Val 
        35                  40                  45              


Gln Gln Phe Gly Ala Pro Gly Gly Leu Gly Glu Thr Leu Gln Gln Lys 
    50                  55                  60                  


Leu Leu Glu Arg Gln Glu Lys Thr Ala Asn Trp Val Ser Glu Tyr Trp 
65                  70                  75                  80  


Leu Asn Asp Met Tyr Leu Asn Asn Arg Leu Ala Leu Pro Val Asn Ser 
                85                  90                  95      


Ser Pro Ala Val Ile Phe Ala Arg Gln His Phe Pro Gly Thr Asp Asp 
            100                 105                 110         


Gln Leu Arg Phe Ala Ala Ser Leu Ile Ser Gly Val Leu Ser Tyr Lys 
        115                 120                 125             


Ala Leu Leu Asp Ser His Ser Ile Pro Thr Asp Cys Ala Lys Gly Gln 
    130                 135                 140                 


Leu Ser Gly Gln Pro Leu Cys Met Lys Gln Tyr Tyr Gly Leu Phe Ser 
145                 150                 155                 160 


Ser Tyr Arg Leu Pro Gly His Thr Gln Asp Thr Leu Val Ala Gln Asn 
                165                 170                 175     


Ser Ser Ile Met Pro Glu Pro Glu His Val Ile Val Ala Cys Cys Asn 
            180                 185                 190         


Gln Phe Phe Val Leu Asp Val Val Ile Asn Phe Arg Arg Leu Ser Glu 
        195                 200                 205             


Gly Asp Leu Phe Thr Gln Leu Arg Lys Ile Val Lys Met Ala Ser Asn 
    210                 215                 220                 


Glu Asp Glu Arg Leu Pro Pro Ile Gly Leu Leu Thr Ser Asp Gly Arg 
225                 230                 235                 240 


Ser Glu Trp Ala Glu Ala Arg Thr Val Leu Val Lys Asp Ser Thr Asn 
                245                 250                 255     


Arg Asp Ser Leu Asp Met Ile Glu Arg Cys Ile Cys Leu Val Cys Leu 
            260                 265                 270         


Asp Ala Pro Gly Gly Val Glu Leu Ser Asp Thr His Arg Ala Leu Gln 
        275                 280                 285             


Leu Leu His Gly Gly Gly Tyr Ser Lys Asn Gly Ala Asn Arg Trp Tyr 
    290                 295                 300                 


Asp Lys Ser Leu Gln Phe Val Val Gly Arg Asp Gly Thr Cys Gly Val 
305                 310                 315                 320 


Val Cys Glu His Ser Pro Phe Asp Gly Ile Val Leu Val Gln Cys Thr 
                325                 330                 335     


Glu His Leu Leu Lys His Met Thr Gln Ser Ser Arg Lys Leu Ile Arg 
            340                 345                 350         


Ala Asp Ser Val Ser Glu Leu Pro Ala Pro Arg Arg Leu Arg Trp Lys 
        355                 360                 365             


Cys Ser Pro Glu Ile Gln Gly His Leu Ala Ser Ser Ala Glu Lys Leu 
    370                 375                 380                 


Gln Arg Ile Val Lys Asn Leu Asp Phe Ile Val Tyr Lys Phe Asp Asn 
385                 390                 395                 400 


Tyr Gly Lys Thr Phe Ile Lys Lys Gln Lys Cys Ser Pro Asp Ala Phe 
                405                 410                 415     


Ile Gln Val Ala Leu Gln Leu Ala Phe Tyr Arg Leu His Arg Arg Leu 
            420                 425                 430         


Val Pro Thr Tyr Glu Ser Ala Ser Ile Arg Arg Phe Gln Glu Gly Arg 
        435                 440                 445             


Val Asp Asn Ile Arg Ser Ala Thr Pro Glu Ala Leu Ala Phe Val Arg 
    450                 455                 460                 


Ala Val Thr Asp His Lys Ala Ala Val Pro Ala Ser Glu Lys Leu Leu 
465                 470                 475                 480 


Leu Leu Lys Asp Ala Ile Arg Ala Gln Thr Ala Tyr Thr Val Met Ala 
                485                 490                 495     


Ile Thr Gly Met Ala Ile Asp Asn His Leu Leu Ala Leu Arg Glu Leu 
            500                 505                 510         


Ala Arg Ala Met Cys Lys Glu Leu Pro Glu Met Phe Met Asp Glu Thr 
        515                 520                 525             


Tyr Leu Met Ser Asn Arg Phe Val Leu Ser Thr Ser Gln Val Pro Thr 
    530                 535                 540                 


Thr Thr Glu Met Phe Cys Cys Tyr Gly Pro Val Val Pro Asn Gly Tyr 
545                 550                 555                 560 


Gly Ala Cys Tyr Asn Pro Gln Pro Glu Thr Ile Leu Phe Cys Ile Ser 
                565                 570                 575     


Ser Phe His Ser Cys Lys Glu Thr Ser Ser Ser Lys Phe Ala Lys Ala 
            580                 585                 590         


Val Glu Glu Ser Leu Ile Asp Met Arg Asp Leu Cys Ser Leu Leu Pro 
        595                 600                 605             


Pro Thr Glu Ser Lys Pro Leu Ala Thr Lys Glu Lys Ala Thr Arg Pro 
    610                 615                 620                 


Ser Gln Gly His Gln Pro 
625                 630 


<210>  43
<211>  2411
<212>  DNA
<213>  Homo sapiens

<400>  43
aagagccgac gcgaggggag gggagcgcag cggcggggct aacgggcggg caagcgggcg       60

ggcggcaaca gcatgtccct cggccagcgc gggcggcctc ttagcgcggc gggggctgct      120

ctgggcgcgc cccgggcgaa gtgcgcccag tctccggccc cggcccctcg gcgcgcccga      180

cttcccggcc gcccctgagc ccagcagccg cgggtcccgg gatcggctaa gagtagctgc      240

aacgcctcgc cggacggagt cctttccttt cccgggacgc tgggccatga gctccgcggc      300

cacctgaggc acaggggagt ctgctcggcc aggacagcct ccccgaagtc ccgtgccctc      360

gcctctgcac tgcgggacgc cagcgctcgg ccctggcgga ggcgtcctcg gaagagcatc      420

ggggtggggg catggaatcc gcggaacctg cgggccaggc ccgggcggcg gccaccaagc      480

tgtcggaggc tgtgggcgcg gcgctgcagg agccccggcg gcagaggcgc ctggtgcttg      540

ttatcgtgtg cgtggcgctg ttactggaca acatgctgta catggtcatc gtgcccatag      600

tgcccgacta catcgcccac atgcgcgggg gcggcgaggg ccccacccgg actcccgagg      660

tgtgggagcc caccctgccg ctgcccactc cggccaatgc cagcgcctac acggccaaca      720

cctcggcgtc cccgacagct gcgtggccag cgggctcagc ccttcggccc cgctacccta      780

cggagagcga agacgtgaag atcggggtgc tgtttgcttc caaggctatc ctgcagctgc      840

tagtgaaccc cttgagcggg cccttcatcg accgcatgag ctacgacgtg ccgctgctga      900

tcggcctggg cgtcatgttc gcctctacag tcctgttcgc cttcgccgag gactacgcca      960

cgctgttcgc ggcgcgcagc ctgcagggcc tgggctcagc cttcgccgac acgtctggca     1020

tagccatgat cgccgataag tacccggagg agccggagcg cagtcgtgca ctgggcgtgg     1080

cgctggcctt cattagcttc ggaagcctag tggccccgcc cttcgggggc atcctctatg     1140

agttcgccgg caagcgcgtg cccttcttgg tgctagctgc cgtgtcgctc tttgacgcgc     1200

tgttgctgct ggcagtggcc aaacccttct cggcggctgc acgggctcgg gccaacctgc     1260

cagtgggcac tcccatccac cgcctcatgc tagaccccta cattgccgtg gtggccggcg     1320

cgctcaccac ctgtaacatt cccctcgcct tcctcgaacc caccattgcc acgtggatga     1380

agcatacgat ggcggcttcc gagtgggaga tgggcatggc ctggctgccg gccttcgtgc     1440

ctcatgtgct gggcgtctac ctcaccgtgc gcctggcggc gcgctaccca cacctgcagt     1500

ggctgtacgg cgcgcttggg ctggctgtga tcggcgccag ctcgtgcatc gtgcccgcct     1560

gccgctcctt cgcgccgcta gtggtctcac tatgcggcct ctgttttggc atagccctag     1620

tcgacacagc actgctgccc acgctcgcct tcctggtgga cgtgcgccat gtctcagtct     1680

atggcagcgt ctacgccatc gccgacatct cctattcggt ggcctacgcg ctcgggccca     1740

tagtggcagg ccacattgtg cactcgctgg gctttgagca gctcagcctt ggcatgggac     1800

tggccaacct gctctatgct cccgtcttgc tgctgctccg caacgtgggc ctcctgacgc     1860

gctcccgttc cgagcgcgat gtgctgcttg atgagccacc gcaaggtctg tacgatgcgg     1920

tgcgcctgcg tgagcgtcct gtgtctggcc aggacggcga gcctcgcagc ccgcctggcc     1980

cttttgatgc gtgcgaggac gactacaact actactacac ccgcagctag catccccact     2040

cctcctccag cccacccaac cgccttgggt caagggggct gctctgcaag cccactggcc     2100

agctctggct cagggcccac ctcctccagc gagtacccca gccactcctc aaccttgact     2160

tctgcccaaa tcccctccct gtgacccgtt ccatatccct ttctctcttg tccaatgggg     2220

cttggagcac cgaggccagc gaagccatcg cgctccttgc ggaggtgaag aggaccctga     2280

gtccccacct gcggctcccc tgtgtagagc ctgcatctgt ctgtccttcc ttccattgct     2340

cccagtgcca aacttgggcc gctgcaccgc ggcgcctccg cccaaatcaa taaactgtgt     2400

ctgtcccagg a                                                          2411


<210>  44
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Ser Ala Glu Pro Ala Gly Gln Ala Arg Ala Ala Ala Thr Lys 
1               5                   10                  15      


Leu Ser Glu Ala Val Gly Ala Ala Leu Gln Glu Pro Arg Arg Gln Arg 
            20                  25                  30          


Arg Leu Val Leu Val Ile Val Cys Val Ala Leu Leu Leu Asp Asn Met 
        35                  40                  45              


Leu Tyr Met Val Ile Val Pro Ile Val Pro Asp Tyr Ile Ala His Met 
    50                  55                  60                  


Arg Gly Gly Gly Glu Gly Pro Thr Arg Thr Pro Glu Val Trp Glu Pro 
65                  70                  75                  80  


Thr Leu Pro Leu Pro Thr Pro Ala Asn Ala Ser Ala Tyr Thr Ala Asn 
                85                  90                  95      


Thr Ser Ala Ser Pro Thr Ala Ala Trp Pro Ala Gly Ser Ala Leu Arg 
            100                 105                 110         


Pro Arg Tyr Pro Thr Glu Ser Glu Asp Val Lys Ile Gly Val Leu Phe 
        115                 120                 125             


Ala Ser Lys Ala Ile Leu Gln Leu Leu Val Asn Pro Leu Ser Gly Pro 
    130                 135                 140                 


Phe Ile Asp Arg Met Ser Tyr Asp Val Pro Leu Leu Ile Gly Leu Gly 
145                 150                 155                 160 


Val Met Phe Ala Ser Thr Val Leu Phe Ala Phe Ala Glu Asp Tyr Ala 
                165                 170                 175     


Thr Leu Phe Ala Ala Arg Ser Leu Gln Gly Leu Gly Ser Ala Phe Ala 
            180                 185                 190         


Asp Thr Ser Gly Ile Ala Met Ile Ala Asp Lys Tyr Pro Glu Glu Pro 
        195                 200                 205             


Glu Arg Ser Arg Ala Leu Gly Val Ala Leu Ala Phe Ile Ser Phe Gly 
    210                 215                 220                 


Ser Leu Val Ala Pro Pro Phe Gly Gly Ile Leu Tyr Glu Phe Ala Gly 
225                 230                 235                 240 


Lys Arg Val Pro Phe Leu Val Leu Ala Ala Val Ser Leu Phe Asp Ala 
                245                 250                 255     


Leu Leu Leu Leu Ala Val Ala Lys Pro Phe Ser Ala Ala Ala Arg Ala 
            260                 265                 270         


Arg Ala Asn Leu Pro Val Gly Thr Pro Ile His Arg Leu Met Leu Asp 
        275                 280                 285             


Pro Tyr Ile Ala Val Val Ala Gly Ala Leu Thr Thr Cys Asn Ile Pro 
    290                 295                 300                 


Leu Ala Phe Leu Glu Pro Thr Ile Ala Thr Trp Met Lys His Thr Met 
305                 310                 315                 320 


Ala Ala Ser Glu Trp Glu Met Gly Met Ala Trp Leu Pro Ala Phe Val 
                325                 330                 335     


Pro His Val Leu Gly Val Tyr Leu Thr Val Arg Leu Ala Ala Arg Tyr 
            340                 345                 350         


Pro His Leu Gln Trp Leu Tyr Gly Ala Leu Gly Leu Ala Val Ile Gly 
        355                 360                 365             


Ala Ser Ser Cys Ile Val Pro Ala Cys Arg Ser Phe Ala Pro Leu Val 
    370                 375                 380                 


Val Ser Leu Cys Gly Leu Cys Phe Gly Ile Ala Leu Val Asp Thr Ala 
385                 390                 395                 400 


Leu Leu Pro Thr Leu Ala Phe Leu Val Asp Val Arg His Val Ser Val 
                405                 410                 415     


Tyr Gly Ser Val Tyr Ala Ile Ala Asp Ile Ser Tyr Ser Val Ala Tyr 
            420                 425                 430         


Ala Leu Gly Pro Ile Val Ala Gly His Ile Val His Ser Leu Gly Phe 
        435                 440                 445             


Glu Gln Leu Ser Leu Gly Met Gly Leu Ala Asn Leu Leu Tyr Ala Pro 
    450                 455                 460                 


Val Leu Leu Leu Leu Arg Asn Val Gly Leu Leu Thr Arg Ser Arg Ser 
465                 470                 475                 480 


Glu Arg Asp Val Leu Leu Asp Glu Pro Pro Gln Gly Leu Tyr Asp Ala 
                485                 490                 495     


Val Arg Leu Arg Glu Arg Pro Val Ser Gly Gln Asp Gly Glu Pro Arg 
            500                 505                 510         


Ser Pro Pro Gly Pro Phe Asp Ala Cys Glu Asp Asp Tyr Asn Tyr Tyr 
        515                 520                 525             


Tyr Thr Arg Ser 
    530         


<210>  45
<211>  2417
<212>  DNA
<213>  Homo sapiens

<400>  45
cttgccatta ggaaatctgt ggacttctag cctgtgtttt aaaccagcca tgtttccttg       60

tatatttccc tacccgctgc cccacatacc cagcatgccg ctgtggccac catgtcctca      120

aagccttctg tctgtatcag gaatgtagtc tgagactgcc aggaagcaac aaggagagag      180

aaacactaac tagtcttcct ttataaccca ttcatactct ctggctgtcc ccaaccttca      240

tagtctcctg catccaaatg tcctctttgg ctcaaaaagt aggccaggca tggtggttca      300

tgcctgtaat agcactttgg gagactgagg tgggaggatc acttggggcc aggagtttga      360

gaccagcttg ggcaacacag cgcaatctcg tctctactaa aaaaaaaaaa aaaaaaaaat      420

tagctgggca tgatggcatg ctcctgtggt cccagctact tgggaggctg aggcaggagg      480

atcacttggt cccaggagtt tgaggcgaca gtgagctagg atcgcaccac tgcactccag      540

cctgagtgac agagcaagac cctgtctcta aaaaaaatta aaatgaaaga ccaggtgctg      600

ggattaagga aacacaggtc tgagggtctg agggaagggg cctgcctccc agggagtcaa      660

catagatgtt ccccatgaac agggatttga ctttggaggc caacctggcc tggcctctgc      720

cctttatctc acactcccta tccttggccc actgccagtc cctgccttgt ggcaaagggg      780

ccccaaaaga aaagctgccc ttccccaaat gtaaggaccc aggtacactt tcacccgtgg      840

aaagcagtgt ctgtcgagag tctgtttcct attaatactt atcaaagcca tgtgcgaggg      900

aggtggtcag ctgtcaatat gccttagtat gtttatatga gtttgttttg ttctaaaata      960

cccaaacagt tctggtcaag cggggctatg cccgtctggc ccaaaacaca gtccgttatt     1020

aacgagatgg ccctggcagg cgggaacaaa tctgcctcca tgcactgctt cctgtagtct     1080

tttagaaagt aactccagga catcgaagtg cccagatttg actcctaagt tctaggagac     1140

tgtagcgcag ggtctgtcaa ccttagcact attggcattt ggggctgggt aattctttct     1200

tgtgggggcc gtcttgggta ctgtaggaag ctgagcagca ttcctggcct ccatccacaa     1260

gatacctgta gcagtgtcct gccaacggta acaatcaagt atgtcatcag acattgccca     1320

atgtccccag ggggcaacac ccctctcttg gacttcaggg tcaagagaat ctctgctggc     1380

taccccagga cttctcatta tagatttcct ggagcacgca gcagaaactt tgcctagccc     1440

agtggttgtt tccattatct gctgccaaag tgggatttga gggtgtccgg gggagggggc     1500

atggggaggg cagtatgctt tcaaaaaccc ctcccaggcc aggcgtggtg gctcatgcct     1560

gtaatcacag gactttggga ggccgaggct ggcagatcac ttgaggctgg gagttagaga     1620

ccaacctggc taacatggca aaacctcgtc tctactaaaa atacaaaaat cagcccggcg     1680

tggtggcggg catctgtaat cccatctact cgggaggctg aggcaggaga attacttgaa     1740

cccaggaggc agaggctgca gtgagccgag atggcaccac tgcactccag cttgttgaca     1800

gaatgagacc ctgtggaaaa aaaaaaaaaa gccctcccat gccagaacag aggatggcag     1860

tctgtttcaa taagacactg tgtccttggt gttggttctg attaagactc actgagatcc     1920

agtgctcttg agctgggtct cagtcccctc ccatgtcctg tgctctgccg ccactgtttt     1980

cattgttgtg ttctcgttgt gattgttaag actcacactc ctggctcagc agtggttttc     2040

cagaaggccc aaagagcggt gccgggcacc ccacgtcgca gtgtccgttc cgggcttggg     2100

aagctgggga ggtgggcaga cctggtcgca tctcaccaca cacacacaca cacacacaca     2160

cacacacgct gtcagaaact cggccgtccc ccctacctct gagctctcaa tgctgctaat     2220

ctctgccaag tgtccctgtg ctccagcacc ttccttgaag gactgacgcc caccccacgc     2280

tctttgcgag gttgtccagg ctgtgtttgt cgcatgctct tcttctgtat agttctcatc     2340

ttccaatttt atgggattca acaaaagcct attatgcttg tttgcattat ggttacaata     2400

ttaaaaagtg gattcaa                                                    2417


<210>  46
<211>  1434
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Asp His Met Phe Gly Val Gln Gln Ile Gln Pro Asn Val Ile 
1               5                   10                  15      


Ser Val Arg Leu Phe Lys Arg Lys Val Gly Gly Leu Gly Phe Leu Val 
            20                  25                  30          


Lys Glu Arg Val Ser Lys Pro Pro Val Ile Ile Ser Asp Leu Ile Arg 
        35                  40                  45              


Gly Gly Ala Ala Glu Gln Ser Gly Leu Ile Gln Ala Gly Asp Ile Ile 
    50                  55                  60                  


Leu Ala Val Asn Gly Arg Pro Leu Val Asp Leu Ser Tyr Asp Ser Ala 
65                  70                  75                  80  


Leu Glu Val Leu Arg Gly Ile Ala Ser Glu Thr His Val Val Leu Ile 
                85                  90                  95      


Leu Arg Gly Pro Glu Gly Phe Thr Thr His Leu Glu Thr Thr Phe Thr 
            100                 105                 110         


Gly Asp Gly Thr Pro Lys Thr Ile Arg Val Thr Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Lys Ala Val Asp Leu Ser His Gln Pro Pro Ala Gly Lys Glu 
    130                 135                 140                 


Gln Pro Leu Ala Val Asp Gly Ala Ser Gly Pro Gly Asn Gly Pro Gln 
145                 150                 155                 160 


His Ala Tyr Asp Asp Gly Gln Glu Ala Gly Ser Leu Pro His Ala Asn 
                165                 170                 175     


Gly Leu Ala Pro Arg Pro Pro Gly Gln Asp Pro Ala Lys Lys Ala Thr 
            180                 185                 190         


Arg Val Ser Leu Gln Gly Arg Gly Glu Asn Asn Glu Leu Leu Lys Glu 
        195                 200                 205             


Ile Glu Pro Val Leu Ser Leu Leu Thr Ser Gly Ser Arg Gly Val Lys 
    210                 215                 220                 


Gly Gly Ala Pro Ala Lys Ala Glu Met Lys Asp Met Gly Ile Gln Val 
225                 230                 235                 240 


Asp Arg Asp Leu Asp Gly Lys Ser His Lys Pro Leu Pro Leu Gly Val 
                245                 250                 255     


Glu Asn Asp Arg Val Phe Asn Asp Leu Trp Gly Lys Gly Asn Val Pro 
            260                 265                 270         


Val Val Leu Asn Asn Pro Tyr Ser Glu Lys Glu Gln Pro Pro Thr Ser 
        275                 280                 285             


Gly Lys Gln Ser Pro Thr Lys Asn Gly Ser Pro Ser Lys Cys Pro Arg 
    290                 295                 300                 


Phe Leu Lys Val Lys Asn Trp Glu Thr Glu Val Val Leu Thr Asp Thr 
305                 310                 315                 320 


Leu His Leu Lys Ser Thr Leu Glu Thr Gly Cys Thr Glu Tyr Ile Cys 
                325                 330                 335     


Met Gly Ser Ile Met His Pro Ser Gln His Ala Arg Arg Pro Glu Asp 
            340                 345                 350         


Val Arg Thr Lys Gly Gln Leu Phe Pro Leu Ala Lys Glu Phe Ile Asp 
        355                 360                 365             


Gln Tyr Tyr Ser Ser Ile Lys Arg Phe Gly Ser Lys Ala His Met Glu 
    370                 375                 380                 


Arg Leu Glu Glu Val Asn Lys Glu Ile Asp Thr Thr Ser Thr Tyr Gln 
385                 390                 395                 400 


Leu Lys Asp Thr Glu Leu Ile Tyr Gly Ala Lys His Ala Trp Arg Asn 
                405                 410                 415     


Ala Ser Arg Cys Val Gly Arg Ile Gln Trp Ser Lys Leu Gln Val Phe 
            420                 425                 430         


Asp Ala Arg Asp Cys Thr Thr Ala His Gly Met Phe Asn Tyr Ile Cys 
        435                 440                 445             


Asn His Val Lys Tyr Ala Thr Asn Lys Gly Asn Leu Arg Ser Ala Ile 
    450                 455                 460                 


Thr Ile Phe Pro Gln Arg Thr Asp Gly Lys His Asp Phe Arg Val Trp 
465                 470                 475                 480 


Asn Ser Gln Leu Ile Arg Tyr Ala Gly Tyr Lys Gln Pro Asp Gly Ser 
                485                 490                 495     


Thr Leu Gly Asp Pro Ala Asn Val Gln Phe Thr Glu Ile Cys Ile Gln 
            500                 505                 510         


Gln Gly Trp Lys Pro Pro Arg Gly Arg Phe Asp Val Leu Pro Leu Leu 
        515                 520                 525             


Leu Gln Ala Asn Gly Asn Asp Pro Glu Leu Phe Gln Ile Pro Pro Glu 
    530                 535                 540                 


Leu Val Leu Glu Val Pro Ile Arg His Pro Lys Phe Glu Trp Phe Lys 
545                 550                 555                 560 


Asp Leu Gly Leu Lys Trp Tyr Gly Leu Pro Ala Val Ser Asn Met Leu 
                565                 570                 575     


Leu Glu Ile Gly Gly Leu Glu Phe Ser Ala Cys Pro Phe Ser Gly Trp 
            580                 585                 590         


Tyr Met Gly Thr Glu Ile Gly Val Arg Asp Tyr Cys Asp Asn Ser Arg 
        595                 600                 605             


Tyr Asn Ile Leu Glu Glu Val Ala Lys Lys Met Asn Leu Asp Met Arg 
    610                 615                 620                 


Lys Thr Ser Ser Leu Trp Lys Asp Gln Ala Leu Val Glu Ile Asn Ile 
625                 630                 635                 640 


Ala Val Leu Tyr Ser Phe Gln Ser Asp Lys Val Thr Ile Val Asp His 
                645                 650                 655     


His Ser Ala Thr Glu Ser Phe Ile Lys His Met Glu Asn Glu Tyr Arg 
            660                 665                 670         


Cys Arg Gly Gly Cys Pro Ala Asp Trp Val Trp Ile Val Pro Pro Met 
        675                 680                 685             


Ser Gly Ser Ile Thr Pro Val Phe His Gln Glu Met Leu Asn Tyr Arg 
    690                 695                 700                 


Leu Thr Pro Ser Phe Glu Tyr Gln Pro Asp Pro Trp Asn Thr His Val 
705                 710                 715                 720 


Trp Lys Gly Thr Asn Gly Thr Pro Thr Lys Arg Arg Ala Ile Gly Phe 
                725                 730                 735     


Lys Lys Leu Ala Glu Ala Val Lys Phe Ser Ala Lys Leu Met Gly Gln 
            740                 745                 750         


Ala Met Ala Lys Arg Val Lys Ala Thr Ile Leu Tyr Ala Thr Glu Thr 
        755                 760                 765             


Gly Lys Ser Gln Ala Tyr Ala Lys Thr Leu Cys Glu Ile Phe Lys His 
    770                 775                 780                 


Ala Phe Asp Ala Lys Val Met Ser Met Glu Glu Tyr Asp Ile Val His 
785                 790                 795                 800 


Leu Glu His Glu Thr Leu Val Leu Val Val Thr Ser Thr Phe Gly Asn 
                805                 810                 815     


Gly Asp Pro Pro Glu Asn Gly Glu Lys Phe Gly Cys Ala Leu Met Glu 
            820                 825                 830         


Met Arg His Pro Asn Ser Val Gln Glu Glu Arg Lys Ser Tyr Lys Val 
        835                 840                 845             


Arg Phe Asn Ser Val Ser Ser Tyr Ser Asp Ser Gln Lys Ser Ser Gly 
    850                 855                 860                 


Asp Gly Pro Asp Leu Arg Asp Asn Phe Glu Ser Ala Gly Pro Leu Ala 
865                 870                 875                 880 


Asn Val Arg Phe Ser Val Phe Gly Leu Gly Ser Arg Ala Tyr Pro His 
                885                 890                 895     


Phe Cys Ala Phe Gly His Ala Val Asp Thr Leu Leu Glu Glu Leu Gly 
            900                 905                 910         


Gly Glu Arg Ile Leu Lys Met Arg Glu Gly Asp Glu Leu Cys Gly Gln 
        915                 920                 925             


Glu Glu Ala Phe Arg Thr Trp Ala Lys Lys Val Phe Lys Ala Ala Cys 
    930                 935                 940                 


Asp Val Phe Cys Val Gly Asp Asp Val Asn Ile Glu Lys Ala Asn Asn 
945                 950                 955                 960 


Ser Leu Ile Ser Asn Asp Arg Ser Trp Lys Arg Asn Lys Phe Arg Leu 
                965                 970                 975     


Thr Phe Val Ala Glu Ala Pro Glu Leu Thr Gln Gly Leu Ser Asn Val 
            980                 985                 990         


His Lys Lys Arg Val Ser Ala Ala  Arg Leu Leu Ser Arg  Gln Asn Leu 
        995                 1000                 1005             


Gln Ser  Pro Lys Ser Ser Arg  Ser Thr Ile Phe Val  Arg Leu His 
    1010                 1015                 1020             


Thr Asn  Gly Ser Gln Glu Leu  Gln Tyr Gln Pro Gly  Asp His Leu 
    1025                 1030                 1035             


Gly Val  Phe Pro Gly Asn His  Glu Asp Leu Val Asn  Ala Leu Ile 
    1040                 1045                 1050             


Glu Arg  Leu Glu Asp Ala Pro  Pro Val Asn Gln Met  Val Lys Val 
    1055                 1060                 1065             


Glu Leu  Leu Glu Glu Arg Asn  Thr Ala Leu Gly Val  Ile Ser Asn 
    1070                 1075                 1080             


Trp Thr  Asp Glu Leu Arg Leu  Pro Pro Cys Thr Ile  Phe Gln Ala 
    1085                 1090                 1095             


Phe Lys  Tyr Tyr Leu Asp Ile  Thr Thr Pro Pro Thr  Pro Leu Gln 
    1100                 1105                 1110             


Leu Gln  Gln Phe Ala Ser Leu  Ala Thr Ser Glu Lys  Glu Lys Gln 
    1115                 1120                 1125             


Arg Leu  Leu Val Leu Ser Lys  Gly Leu Gln Glu Tyr  Glu Glu Trp 
    1130                 1135                 1140             


Lys Trp  Gly Lys Asn Pro Thr  Ile Val Glu Val Leu  Glu Glu Phe 
    1145                 1150                 1155             


Pro Ser  Ile Gln Met Pro Ala  Thr Leu Leu Leu Thr  Gln Leu Ser 
    1160                 1165                 1170             


Leu Leu  Gln Pro Arg Tyr Tyr  Ser Ile Ser Ser Ser  Pro Asp Met 
    1175                 1180                 1185             


Tyr Pro  Asp Glu Val His Leu  Thr Val Ala Ile Val  Ser Tyr Arg 
    1190                 1195                 1200             


Thr Arg  Asp Gly Glu Gly Pro  Ile His His Gly Val  Cys Ser Ser 
    1205                 1210                 1215             


Trp Leu  Asn Arg Ile Gln Ala  Asp Glu Leu Val Pro  Cys Phe Val 
    1220                 1225                 1230             


Arg Gly  Ala Pro Ser Phe His  Leu Pro Arg Asn Pro  Gln Val Pro 
    1235                 1240                 1245             


Cys Ile  Leu Val Gly Pro Gly  Thr Gly Ile Ala Pro  Phe Arg Ser 
    1250                 1255                 1260             


Phe Trp  Gln Gln Arg Gln Phe  Asp Ile Gln His Lys  Gly Met Asn 
    1265                 1270                 1275             


Pro Cys  Pro Met Val Leu Val  Phe Gly Cys Arg Gln  Ser Lys Ile 
    1280                 1285                 1290             


Asp His  Ile Tyr Arg Glu Glu  Thr Leu Gln Ala Lys  Asn Lys Gly 
    1295                 1300                 1305             


Val Phe  Arg Glu Leu Tyr Thr  Ala Tyr Ser Arg Glu  Pro Asp Lys 
    1310                 1315                 1320             


Pro Lys  Lys Tyr Val Gln Asp  Ile Leu Gln Glu Gln  Leu Ala Glu 
    1325                 1330                 1335             


Ser Val  Tyr Arg Ala Leu Lys  Glu Gln Gly Gly His  Ile Tyr Val 
    1340                 1345                 1350             


Cys Gly  Asp Val Thr Met Ala  Ala Asp Val Leu Lys  Ala Ile Gln 
    1355                 1360                 1365             


Arg Ile  Met Thr Gln Gln Gly  Lys Leu Ser Ala Glu  Asp Ala Gly 
    1370                 1375                 1380             


Val Phe  Ile Ser Arg Met Arg  Asp Asp Asn Arg Tyr  His Glu Asp 
    1385                 1390                 1395             


Ile Phe  Gly Val Thr Leu Arg  Thr Tyr Glu Val Thr  Asn Arg Leu 
    1400                 1405                 1410             


Arg Ser  Glu Ser Ile Ala Phe  Ile Glu Glu Ser Lys  Lys Asp Thr 
    1415                 1420                 1425             


Asp Glu  Val Phe Ser Ser 
    1430                 


<210>  47
<211>  2409
<212>  DNA
<213>  Homo sapiens

<400>  47
gagattctgc tttggagggt aaagtgggga agaaatcgga ttcccagagg tgaatcagct       60

cctctcctac ttgtgactag agggtggtgg aggtaaggcc ttccagagcc catggcttca      120

ggagagggtc tctctccagg actgccaggc tgctggagga cctgccccta cctgctgcat      180

cgtcaggctc ccacgctttg tccgtgatgc ccccctaccc cctcactctc cccgtctcca      240

tggtcccgac caggaaggga agccatcggt accttctcag gtactttgtt tctggatatc      300

acgatgctgc gagttgccta accctccccc tacctttatg agaggaattc cttctccagg      360

cccttgctga gattgtagag attgagtgct ctggaccgca aaagccaggc tagtccttgt      420

agggtgagca tggaattgga atgtgtcaca gtggataagc ttttagagga actgaatcca      480

aacattttct ccagccggac attgaatgtt gctacaaagg gagccttgaa gctttaacat      540

ggttcaggcc cttggtgtga gagcccaggg ggaggacagc ttgtctgctg ctccaaatca      600

cttagatctg attcctgttt tgaaagtcct gccctgcctt cctcctgcct gtagcccagc      660

ccatctaaat ggaagctggg aattgcccct cacctcccct gtgtcctgtc cagctgaagc      720

ttttgcagca ctttacctct ctgaaagccc cagaggacca gagcccccag ccttacctct      780

caacctgtcc cctccactgg gcagtggtgg tcagttttta ctgcaaaaaa aaaaaaagaa      840

aaaagagaaa gaaaaaaaag aatgaatgca agctgatagc tgagactgtg agactgtttt      900

tgtccactct tctgaatcac tgccacttgg gtcagggacc acagccattg ccacccttgg      960

cccatctctc tgcgtgcgtg ccttgagcac acatataaaa agtgccatgt gcaattgtct     1020

tatcttttat gatctaggct ttgcctaggg atcactactc cttaacgggc tggctggggc     1080

aatgaggaaa agctcctttg ctcctgtaag gccataagtg gctgttaaca gattttcaaa     1140

tgcctgaaga gattgctgag acctgctaga gtcatatgtt cggggaatta agtctttatc     1200

ctagacaaca aggtacagat gcaaactgca gtgttattgg agggtcaatc ggcaaggata     1260

tgattatccc aaaatggagt tcatcgaccc tagctttcct ttagattata tataaataaa     1320

agtgcagtcc tcttctaatg gccacagttg gttttcttgt agcccagaaa gtccaaatta     1380

aaggaaataa attcagtttt atgttagcct tccttggtgc atcagggtgt cagtggaaat     1440

aggatcaggt ggtgtgtgtg tgtgtgtttt gtgtgtgtgt gtacacatgt gtttatatat     1500

acatgtgtga gggaaagtgt gtacatatat gtaggattgt aaccagacgg aaaagaacga     1560

ggatctccag ggtgtttgaa tcagcaacag atttgtgttt tctaacatgc atttagttgg     1620

agaggcatgg ttctgtttgt tttgttttga tctaatttgc cattggaaat aggtacagtt     1680

acacagagaa ggaagaacca ggaaagtgag atccatgaaa ctaaatgagc agctgtcaga     1740

atccagtgtg gctgagccta cctagcttat gaaatctaac ccagggttcc ctgagtccaa     1800

gaccacttag attattaaga ttttgaacgt ccagaggagt gaaaagtctg ttttctgacg     1860

taagccggag ctgaggataa agccagaggc cagtggatta ggtgtatgga atgtggatgg     1920

agagggcttg tgtgggatgt ggccagggag tgggtgagga aggccgcttc taaatggcct     1980

gtaaaaactt gagattggat agacgaaagg aaatggagaa attaaagaat tggagaaact     2040

agttatctgt gttgctgact ttgggaccca tccaagactc ctgcccttgg ggtgttccat     2100

ggtggtttct tcctgcctgg gcgccaccct ttccccagtt caggccctcc ctggaggact     2160

agtttgtgta ttggtatcct ccccagtgga cccaaaccag cgcatacttg gtgtgtggag     2220

atgggagaca aaggacagat ctaggagcct tgaaggatca ccagccaccg accctccatc     2280

agggccaact gggcaggaaa gggaacattg cagacctgat ttcccgacga tgtcaccctg     2340

tcctccctcc ttgcttcttg ctctgctaac tcaactctgc cttcctcttt ttcattcttc     2400

tactctgcc                                                             2409


<210>  48
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Leu Ser Ser Leu Cys Pro Val Phe Ser Ala Ala Ala Ser Ser 
1               5                   10                  15      


Leu Gln Val His Leu Leu Lys Asp Gln Leu Ala Ala Glu Ala Ala Ala 
            20                  25                  30          


Arg Leu Glu Ala Gln Ala Arg Val His Gln Leu Leu Leu Gln Asn Lys 
        35                  40                  45              


Asp Met Leu Gln His Ile Ser Leu Leu Val Lys Gln Val Gln Glu Leu 
    50                  55                  60                  


Glu Leu Lys Leu Ser Gly Gln Asn Ala Met Gly Ser Gln Asp Ser Leu 
65                  70                  75                  80  


Leu Glu Ile Thr Phe Arg Ser Gly Ala Leu Pro Val Leu Cys Asp Pro 
                85                  90                  95      


Thr Thr Pro Lys Pro Glu Asp Leu His Ser Pro Pro Leu Gly Ala Gly 
            100                 105                 110         


Leu Ala Asp Phe Ala His Pro Ala Gly Ser Pro Leu Gly Arg Arg Asp 
        115                 120                 125             


Cys Leu Val Lys Leu Glu Cys Phe Arg Phe Leu Pro Pro Glu Asp Thr 
    130                 135                 140                 


Pro Pro Pro Ala Gln Gly Glu Ala Leu Leu Gly Gly Leu Glu Leu Ile 
145                 150                 155                 160 


Lys Phe Arg Glu Ser Gly Ile Ala Ser Glu Tyr Glu Ser Asn Thr Asp 
                165                 170                 175     


Glu Ser Glu Glu Arg Asp Ser Trp Ser Gln Glu Glu Leu Pro Arg Leu 
            180                 185                 190         


Leu Asn Val Leu Gln Arg Gln Glu Leu Gly Asp Gly Leu Asp Asp Glu 
        195                 200                 205             


Ile Ala Val 
    210     


<210>  49
<211>  3279
<212>  DNA
<213>  Homo sapiens

<400>  49
ctcttctcct ggcgctcgcg tgcgagaggg aactagcgag aacgaggaag cagctggagg       60

tgacgccggg cagattacgc ctgtcagggc cgagccgagc ggatcgctgg gcgctgtgca      120

gaggaaaggc gggagtgccc ggctcgctgt cgcagagccg agcctgtttc tgcgccggac      180

cagtcgagga ctctggacag tagaggcccc gggacgaccg agctgatggc gtcttcgacc      240

ccatcttcgt ccgcaacctc ctcgaacgcg ggagcggacc ccaataccac taacctgcgc      300

cccacaacgt acgatacctg gtgcggcgtg gcccatggat gcaccagaaa actggggctc      360

aagatctgcg gcttcttgca aaggaccaac agcctggaag agaagagtcg ccttgtgagt      420

gccttcaagg agaggcaatc ctccaagaac ctgctttcct gtgaaaacag cgaccgggat      480

gcccgcttcc ggcgcacaga gactgacttc tctaatctgt ttgctagaga tctgcttccg      540

gctaagaacg gtgaggagca aaccgtgcaa ttcctcctgg aagtggtgga catactcctc      600

aactatgtcc gcaagacatt tgatcgctcc accaaggtgc tggactttca tcacccacac      660

cagttgctgg aaggcatgga gggcttcaac ttggagctct ctgaccaccc cgagtccctg      720

gagcagatcc tggttgactg cagagacacc ttgaagtatg gggttcgcac aggtcatcct      780

cgatttttca accagctctc cactggattg gatattattg gcctagctgg agaatggctg      840

acatcaacgg ccaataccaa catgtttaca tatgaaattg caccagtgtt tgtcctcatg      900

gaacaaataa cacttaagaa gatgagagag atagttggat ggtcaagtaa agatggtgat      960

gggatatttt ctcctggggg cgccatatcc aacatgtaca gcatcatggc tgctcgctac     1020

aagtacttcc cggaagttaa gacaaagggc atggcggctg tgcctaaact ggtcctcttc     1080

acctcagaac agagtcacta ttccataaag aaagctgggg ctgcacttgg ctttggaact     1140

gacaatgtga ttttgataaa gtgcaatgaa agggggaaaa taattccagc tgattttgag     1200

gcaaaaattc ttgaagccaa acagaaggga tatgttccct tttatgtcaa tgcaactgct     1260

ggcacgactg tttatggagc ttttgatccg atacaagaga ttgcagatat atgtgagaaa     1320

tataaccttt ggttgcatgt cgatgctgcc tggggaggtg ggctgctcat gtccaggaag     1380

caccgccata aactcaacgg catagaaagg gccaactcag tcacctggaa ccctcacaag     1440

atgatgggcg tgctgttgca gtgctctgcc attctcgtca aggaaaaggg tatactccaa     1500

ggatgcaacc agatgtgtgc aggatacctc ttccagccag acaagcagta tgatgtctcc     1560

tacgacaccg gggacaaggc aattcagtgt ggccgccacg tggatatctt caagttctgg     1620

ctgatgtgga aagcaaaggg cacagtggga tttgaaaacc agatcaacaa atgcctggaa     1680

ctggctgaat acctctatgc caagattaaa aacagagaag aatttgagat ggttttcaat     1740

ggcgagcctg agcacacaaa cgtctgtttt tggtatattc cacaaagcct caggggtgtg     1800

ccagacagcc ctcaacgacg ggaaaagcta cacaaggtgg ctccaaaaat caaagccctg     1860

atgatggagt caggtacgac catggttggc taccagcccc aaggggacaa ggccaacttc     1920

ttccggatgg tcatctccaa cccagccgct acccagtctg acattgactt cctcattgag     1980

gagatagaaa gactgggcca ggatctgtaa tcatccttcg cagaacatga gtttatggga     2040

atgccttttc cctctggcac tccagaacaa acctctatat gttgctgaaa cacacaggcc     2100

atttcattga gggaaaacat aatatcttga agaatattgt taaaacctta cttaaagctt     2160

gtttgttcta gttagcagga aatagtgttc tttttaaaaa gttgcacatt aggaacagag     2220

tatatatgta cagttataca tacctctctc tatatataca tgtatagtga gtgtggctta     2280

gtaatagatc acggcatgtt tcccgctcca agagaattca ctttaccttc agcagttacc     2340

gaggagctaa acatgctgcc aaccagcttg tccaacaact ccaggaaaac tgtttttcaa     2400

aacgccatgt cctaggggcc gagggaaatg ctgttggtga gaatcgacct cactgtcagc     2460

gtttctccac ctgaagtgat gatggatgag aaaaaacacc accaaatgac aagtcacacc     2520

ctccccatta gtatcctgtt aggggaaaat agtagcagag tcattgttac aggtgtacta     2580

tggctgtatt tttagagatt aatttgtgta gattgtgtaa attcctgttg tctgaccttg     2640

gtggtgggag ggggagacta tgtgtcatga tttcaatgat tgtttaattg taggtcaatg     2700

aaatatttgc ttatttatat tcagagatgt accatgttaa agaggcgtct tgtattttct     2760

tcccatttgt aatgtatctt atttatatat gaagtaagtt ctgaaaactg tttatggtat     2820

tttcgtgcat ttgtgagcca aagagaaaag attaaaatta gtgagatttg tatttatatt     2880

agagtgccct taaaataatg atttaagcat tttactgtct gtaagagaat tctaagattg     2940

tacataaagt catatatatg gaaatcctgt tacttaaata gcatctgctc ttctcttacg     3000

ctctctgtct ggctgtacgt ctggtgttct caatgctttt ctagcaactg ttggataata     3060

actagatctc ctgtaatttt gtagtagttg atgaccaatc tctgtgactc gcttagctga     3120

aacctaaggc aacatttccg aagaccttct gaagatctca gataaagtga ccaggctcac     3180

aactgttttt gaagaaggga aattcacact gtgcgtttta gagtatgcaa gaagaatata     3240

aataaataaa aatattctcc atggagaatt tgaacaaaa                            3279


<210>  50
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ser Ser Thr Pro Ser Ser Ser Ala Thr Ser Ser Asn Ala Gly 
1               5                   10                  15      


Ala Asp Pro Asn Thr Thr Asn Leu Arg Pro Thr Thr Tyr Asp Thr Trp 
            20                  25                  30          


Cys Gly Val Ala His Gly Cys Thr Arg Lys Leu Gly Leu Lys Ile Cys 
        35                  40                  45              


Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys Ser Arg Leu Val 
    50                  55                  60                  


Ser Ala Phe Lys Glu Arg Gln Ser Ser Lys Asn Leu Leu Ser Cys Glu 
65                  70                  75                  80  


Asn Ser Asp Arg Asp Ala Arg Phe Arg Arg Thr Glu Thr Asp Phe Ser 
                85                  90                  95      


Asn Leu Phe Ala Arg Asp Leu Leu Pro Ala Lys Asn Gly Glu Glu Gln 
            100                 105                 110         


Thr Val Gln Phe Leu Leu Glu Val Val Asp Ile Leu Leu Asn Tyr Val 
        115                 120                 125             


Arg Lys Thr Phe Asp Arg Ser Thr Lys Val Leu Asp Phe His His Pro 
    130                 135                 140                 


His Gln Leu Leu Glu Gly Met Glu Gly Phe Asn Leu Glu Leu Ser Asp 
145                 150                 155                 160 


His Pro Glu Ser Leu Glu Gln Ile Leu Val Asp Cys Arg Asp Thr Leu 
                165                 170                 175     


Lys Tyr Gly Val Arg Thr Gly His Pro Arg Phe Phe Asn Gln Leu Ser 
            180                 185                 190         


Thr Gly Leu Asp Ile Ile Gly Leu Ala Gly Glu Trp Leu Thr Ser Thr 
        195                 200                 205             


Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu 
    210                 215                 220                 


Met Glu Gln Ile Thr Leu Lys Lys Met Arg Glu Ile Val Gly Trp Ser 
225                 230                 235                 240 


Ser Lys Asp Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn 
                245                 250                 255     


Met Tyr Ser Ile Met Ala Ala Arg Tyr Lys Tyr Phe Pro Glu Val Lys 
            260                 265                 270         


Thr Lys Gly Met Ala Ala Val Pro Lys Leu Val Leu Phe Thr Ser Glu 
        275                 280                 285             


Gln Ser His Tyr Ser Ile Lys Lys Ala Gly Ala Ala Leu Gly Phe Gly 
    290                 295                 300                 


Thr Asp Asn Val Ile Leu Ile Lys Cys Asn Glu Arg Gly Lys Ile Ile 
305                 310                 315                 320 


Pro Ala Asp Phe Glu Ala Lys Ile Leu Glu Ala Lys Gln Lys Gly Tyr 
                325                 330                 335     


Val Pro Phe Tyr Val Asn Ala Thr Ala Gly Thr Thr Val Tyr Gly Ala 
            340                 345                 350         


Phe Asp Pro Ile Gln Glu Ile Ala Asp Ile Cys Glu Lys Tyr Asn Leu 
        355                 360                 365             


Trp Leu His Val Asp Ala Ala Trp Gly Gly Gly Leu Leu Met Ser Arg 
    370                 375                 380                 


Lys His Arg His Lys Leu Asn Gly Ile Glu Arg Ala Asn Ser Val Thr 
385                 390                 395                 400 


Trp Asn Pro His Lys Met Met Gly Val Leu Leu Gln Cys Ser Ala Ile 
                405                 410                 415     


Leu Val Lys Glu Lys Gly Ile Leu Gln Gly Cys Asn Gln Met Cys Ala 
            420                 425                 430         


Gly Tyr Leu Phe Gln Pro Asp Lys Gln Tyr Asp Val Ser Tyr Asp Thr 
        435                 440                 445             


Gly Asp Lys Ala Ile Gln Cys Gly Arg His Val Asp Ile Phe Lys Phe 
    450                 455                 460                 


Trp Leu Met Trp Lys Ala Lys Gly Thr Val Gly Phe Glu Asn Gln Ile 
465                 470                 475                 480 


Asn Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Ala Lys Ile Lys Asn 
                485                 490                 495     


Arg Glu Glu Phe Glu Met Val Phe Asn Gly Glu Pro Glu His Thr Asn 
            500                 505                 510         


Val Cys Phe Trp Tyr Ile Pro Gln Ser Leu Arg Gly Val Pro Asp Ser 
        515                 520                 525             


Pro Gln Arg Arg Glu Lys Leu His Lys Val Ala Pro Lys Ile Lys Ala 
    530                 535                 540                 


Leu Met Met Glu Ser Gly Thr Thr Met Val Gly Tyr Gln Pro Gln Gly 
545                 550                 555                 560 


Asp Lys Ala Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr 
                565                 570                 575     


Gln Ser Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln 
            580                 585                 590         


Asp Leu 
        


<210>  51
<211>  2404
<212>  DNA
<213>  Homo sapiens

<400>  51
acgcacgcgc gcgcagggcc aagcccgagg cagctcgccc gcagctcgca ctcgcaggcg       60

acctgctcca gtctccaaag ccgatggcat ctccgggctc tggcttttgg tctttcgggt      120

cggaagatgg ctctggggat tccgagaatc ccggcacagc gcgagcctgg tgccaagtgg      180

ctcagaagtt cacgggcggc atcggaaaca aactgtgcgc cctgctctac ggagacgccg      240

agaagccggc ggagagcggc gggagccaac ccccgcgggc cgccgcccgg aaggccgcct      300

gcgcctgcga ccagaagccc tgcagctgct ccaaagtgga tgtcaactac gcgtttctcc      360

atgcaacaga cctgctgccg gcgtgtgatg gagaaaggcc cactttggcg tttctgcaag      420

atgttatgaa cattttactt cagtatgtgg tgaaaagttt cgatagatca accaaagtga      480

ttgatttcca ttatcctaat gagcttctcc aagaatataa ttgggaattg gcagaccaac      540

cacaaaattt ggaggaaatt ttgatgcatt gccaaacaac tctaaaatat gcaattaaaa      600

cagggcatcc tagatacttc aatcaacttt ctactggttt ggatatggtt ggattagcag      660

cagactggct gacatcaaca gcaaatacta acatgttcac ctatgaaatt gctccagtat      720

ttgtgctttt ggaatatgtc acactaaaga aaatgagaga aatcattggc tggccagggg      780

gctctggcga tgggatattt tctcccggtg gcgccatatc taacatgtat gccatgatga      840

tcgcacgctt taagatgttc ccagaagtca aggagaaagg aatggctgct cttcccaggc      900

tcattgcctt cacgtctgaa catagtcatt tttctctcaa gaagggagct gcagccttag      960

ggattggaac agacagcgtg attctgatta aatgtgatga gagagggaaa atgattccat     1020

ctgatcttga aagaaggatt cttgaagcca aacagaaagg gtttgttcct ttcctcgtga     1080

gtgccacagc tggaaccacc gtgtacggag catttgaccc cctcttagct gtcgctgaca     1140

tttgcaaaaa gtataagatc tggatgcatg tggatgcagc ttggggtggg ggattactga     1200

tgtcccgaaa acacaagtgg aaactgagtg gcgtggagag ggccaactct gtgacgtgga     1260

atccacacaa gatgatggga gtccctttgc agtgctctgc tctcctggtt agagaagagg     1320

gattgatgca gaattgcaac caaatgcatg cctcctacct ctttcagcaa gataaacatt     1380

atgacctgtc ctatgacact ggagacaagg ccttacagtg cggacgccac gttgatgttt     1440

ttaaactatg gctgatgtgg agggcaaagg ggactaccgg gtttgaagcg catgttgata     1500

aatgtttgga gttggcagag tatttataca acatcataaa aaaccgagaa ggatatgaga     1560

tggtgtttga tgggaagcct cagcacacaa atgtctgctt ctggtacatt cctccaagct     1620

tgcgtactct ggaagacaat gaagagagaa tgagtcgcct ctcgaaggtg gctccagtga     1680

ttaaagccag aatgatggag tatggaacca caatggtcag ctaccaaccc ttgggagaca     1740

aggtcaattt cttccgcatg gtcatctcaa acccagcggc aactcaccaa gacattgact     1800

tcctgattga agaaatagaa cgccttggac aagatttata ataaccttgc tcaccaagct     1860

gttccacttc tctagagaac atgccctcag ctaagccccc tactgagaaa cttcctttga     1920

gaattgtgcg acttcacaaa atgcaaggtg aacaccactt tgtctctgag aacagacgtt     1980

accaattatg gagtgtcacc agctgccaaa atcgtaggtg ttggctctgc tggtcactgg     2040

agtagttgct actcttcaga atatggacaa agaaggcaca ggtgtaaata tagtagcagg     2100

atgaggaacc tcaaactggg tatcattttg cacgtgctct tctgttctca aatgctaaat     2160

gcaaacactg tgtatttatt agttaggtgt gccaaactac cgttcccaaa ttggtgtttc     2220

tgaatgacat caacattccc ccaacattac tccattacta aagacagaaa aaaataaaaa     2280

cataaaatat acaaacatgt ggcaacctgt tcttcctacc aaatataaac ttgtgtatga     2340

tccaagtatt ttatctgtgt tgtctctcta aacccaaata aatgtgtaaa tgtggacaca     2400

tctc                                                                  2404


<210>  52
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly 
1               5                   10                  15      


Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val 
            20                  25                  30          


Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu 
        35                  40                  45              


Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro 
    50                  55                  60                  


Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys 
65                  70                  75                  80  


Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp 
                85                  90                  95      


Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln 
            100                 105                 110         


Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg 
        115                 120                 125             


Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu 
    130                 135                 140                 


Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu 
145                 150                 155                 160 


Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro 
                165                 170                 175     


Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala 
            180                 185                 190         


Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu 
        195                 200                 205             


Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met 
    210                 215                 220                 


Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser 
225                 230                 235                 240 


Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe 
                245                 250                 255     


Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg 
            260                 265                 270         


Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly 
        275                 280                 285             


Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys 
    290                 295                 300                 


Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu 
305                 310                 315                 320 


Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala 
                325                 330                 335     


Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp 
            340                 345                 350         


Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly 
        355                 360                 365             


Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val 
    370                 375                 380                 


Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val 
385                 390                 395                 400 


Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln 
                405                 410                 415     


Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His 
            420                 425                 430         


Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg 
        435                 440                 445             


His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr 
    450                 455                 460                 


Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr 
465                 470                 475                 480 


Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp 
                485                 490                 495     


Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser 
            500                 505                 510         


Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys 
        515                 520                 525             


Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met 
    530                 535                 540                 


Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val 
545                 550                 555                 560 


Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu 
                565                 570                 575     


Glu Ile Glu Arg Leu Gly Gln Asp Leu 
            580                 585 


<210>  53
<211>  2415
<212>  DNA
<213>  Homo sapiens

<400>  53
ctaactccat tatcttcact ctttccttct tcctgccacc tcatgcccat tctctttact       60

gtctagcatg ctgaaagaag gaagtgatct aaatgccagc gtgttcagtg gtaaatatta      120

gttggtgcaa aagaaaaacc atgattactt ttgcactaac ctaatagctt tgcaaatttt      180

aagaacttgc tttatgaaga tattcggata tggattctcc ccaccccaca tacttagaca      240

ttgttcaaat atactacttt taaaaaaaca ccttttcaaa cagaattagc gttttgccaa      300

gtctggtatt aatggaattg tacaggagct ttgaaagttt tcaaacttta ttaaactaaa      360

aaaaaaaaat cgaaaatctc tgtctgttcc gcatagtatg catttatttg acccctattt      420

atcaatacta tgatggggtt tttttttttt aaagaaaatt taagagtagg taggtggatt      480

ttaaaataat attttaaaga ccttttatat ctatatgtag catttataga aaaataaaaa      540

ctaaaaatag aattgaattg taacattatt taaggactga agtttttttt cttgtatcag      600

taagaaatac ccaagaggct gggtgcagtg actcacacct gtaatcccag cactttggga      660

ggctgcagtg ggaggatcac atgacatcag gagtttgaga ccagcttggc caacatagtg      720

aaacgccgtc tctattaaaa atacagaaaa ttagctgaat gtggtggcag gcgcctataa      780

ttcctgctac ttgggaggct gaggcaggag aattgcttga acccaggagg cagaggttgc      840

agtgagccaa acgttccact gcattccagc ctggatgaca agagcgaaac tccgtctcaa      900

aaaaaaaaaa aaaaattgtt atgcttagtt ccatggaaag actattctga agctttaagt      960

cttctttttc tattttccat agtattgccc cttccccact tcattgctta actgtctcta     1020

aattttaatg ataataatat tttaaaggtc agataatgcc attagaggca gagacaaacc     1080

tggggaccaa gctaatttct ctgttattga gagcgctaaa gacaggtgaa ctggagtttt     1140

atttcctctg ctagagtgaa ataataccct ctccaccagg cacaatggct cacacctgta     1200

attccagcac tttgggaggc caaggtgggc ggatcacttg aggtcaggag ttcgagacca     1260

gcctggccaa catggtgaaa ccccatctct actaaaaata caaaaattag ccagccatgg     1320

tggcatgctc ctgtaatccc agctacttgg gagactgagg tgggataatc acttgaacct     1380

gggaggcgga ggttgcagtg agctgagatt gtgccactgc actccagcct gggtgacaga     1440

gcaagactcc atctaaaaaa caaaaacaaa aacaaaaaaa ccctctcaat tggtttaata     1500

ccacgataga aaagataaat attttaggat ggaatcttaa atatgtctgt ccttttgttt     1560

catatagttg aaatcaattc agtattgttt ctacattagg tgtttcaaaa acagtcacct     1620

ttgcaacaga agagctcttt tgttgaaaat gattcacaat atatttcagt tggaatgtca     1680

ggtggtattt ctcttaccaa cacctcacag aatctatgcc aagctgctct accaccaatg     1740

caagtatttt tttaaagcta ctaaaataaa ctttcttcac cagccaactc taatttggag     1800

acagtgtgca ttggtgaagg acctcgtcag aataagtttg aatgtctact gaactaagaa     1860

gaattttgtc gtttggggga gagaatagat ggcatcagtc cttcaattct gtaactgaag     1920

actccaatta tagtagataa gaattgtgtc tagcaatttt taaacactga cagtccaaac     1980

aaaaatattt ggtgaggaag gatgtcccat atttttgctt aaatatcata aacaaatatg     2040

agcatttact aattttttaa atggcatttt gaaagattat tcttatttac actctaaaat     2100

taaaggtgta ctttatctta agaaaatgat atattaaaaa ttcatatttt aaaagataaa     2160

attggggaat ttacagttat tttgtgaatg gcctttaaac tatgatttga tctatataca     2220

acttttcaga atacttttga ttgtgtgttg gacatatcta aaattaattt tatctggcag     2280

aattaaacct aaatttattt gtataaaaga gtcccctttc taaaattcat acagtgccct     2340

tgtattcatt tatgcagtgt ttataaatat ttcaagttag attgtgagat attaataaat     2400

gatttatgct gtgaa                                                      2415


<210>  54
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Thr Thr Pro Leu Asn Ser Gln Lys Gln Leu Ser Ala Cys Glu 
1               5                   10                  15      


Asp Gly Glu Asp Cys Gln Glu Asn Gly Val Leu Gln Lys Val Val Pro 
            20                  25                  30          


Thr Pro Gly Asp Lys Val Glu Ser Gly Gln Ile Ser Asn Gly Tyr Ser 
        35                  40                  45              


Ala Val Pro Ser Pro Gly Ala Gly Asp Asp Thr Arg His Ser Ile Pro 
    50                  55                  60                  


Ala Thr Thr Thr Thr Leu Val Ala Glu Leu His Gln Gly Glu Arg Glu 
65                  70                  75                  80  


Thr Trp Gly Lys Lys Val Asp Phe Leu Leu Ser Val Ile Gly Tyr Ala 
                85                  90                  95      


Val Asp Leu Gly Asn Val Trp Arg Phe Pro Tyr Ile Cys Tyr Gln Asn 
            100                 105                 110         


Gly Gly Gly Ala Phe Leu Leu Pro Tyr Thr Ile Met Ala Ile Phe Gly 
        115                 120                 125             


Gly Ile Pro Leu Phe Tyr Met Glu Leu Ala Leu Gly Gln Tyr His Arg 
    130                 135                 140                 


Asn Gly Cys Ile Ser Ile Trp Arg Lys Ile Cys Pro Ile Phe Lys Gly 
145                 150                 155                 160 


Ile Gly Tyr Ala Ile Cys Ile Ile Ala Phe Tyr Ile Ala Ser Tyr Tyr 
                165                 170                 175     


Asn Thr Ile Met Ala Trp Ala Leu Tyr Tyr Leu Ile Ser Ser Phe Thr 
            180                 185                 190         


Asp Gln Leu Pro Trp Thr Ser Cys Lys Asn Ser Trp Asn Thr Gly Asn 
        195                 200                 205             


Cys Thr Asn Tyr Phe Ser Glu Asp Asn Ile Thr Trp Thr Leu His Ser 
    210                 215                 220                 


Thr Ser Pro Ala Glu Glu Phe Tyr Thr Arg His Val Leu Gln Ile His 
225                 230                 235                 240 


Arg Ser Lys Gly Leu Gln Asp Leu Gly Gly Ile Ser Trp Gln Leu Ala 
                245                 250                 255     


Leu Cys Ile Met Leu Ile Phe Thr Val Ile Tyr Phe Ser Ile Trp Lys 
            260                 265                 270         


Gly Val Lys Thr Ser Gly Lys Val Val Trp Val Thr Ala Thr Phe Pro 
        275                 280                 285             


Tyr Ile Ile Leu Ser Val Leu Leu Val Arg Gly Ala Thr Leu Pro Gly 
    290                 295                 300                 


Ala Trp Arg Gly Val Leu Phe Tyr Leu Lys Pro Asn Trp Gln Lys Leu 
305                 310                 315                 320 


Leu Glu Thr Gly Val Trp Ile Asp Ala Ala Ala Gln Ile Phe Phe Ser 
                325                 330                 335     


Leu Gly Pro Gly Phe Gly Val Leu Leu Ala Phe Ala Ser Tyr Asn Lys 
            340                 345                 350         


Phe Asn Asn Asn Cys Tyr Gln Asp Ala Leu Val Thr Ser Val Val Asn 
        355                 360                 365             


Cys Met Thr Ser Phe Val Ser Gly Phe Val Ile Phe Thr Val Leu Gly 
    370                 375                 380                 


Tyr Met Ala Glu Met Arg Asn Glu Asp Val Ser Glu Val Ala Lys Asp 
385                 390                 395                 400 


Ala Gly Pro Ser Leu Leu Phe Ile Thr Tyr Ala Glu Ala Ile Ala Asn 
                405                 410                 415     


Met Pro Ala Ser Thr Phe Phe Ala Ile Ile Phe Phe Leu Met Leu Ile 
            420                 425                 430         


Thr Leu Gly Leu Asp Ser Thr Phe Ala Gly Leu Glu Gly Val Ile Thr 
        435                 440                 445             


Ala Val Leu Asp Glu Phe Pro His Val Trp Ala Lys Arg Arg Glu Arg 
    450                 455                 460                 


Phe Val Leu Ala Val Val Ile Thr Cys Phe Phe Gly Ser Leu Val Thr 
465                 470                 475                 480 


Leu Thr Phe Gly Gly Ala Tyr Val Val Lys Leu Leu Glu Glu Tyr Ala 
                485                 490                 495     


Thr Gly Pro Ala Val Leu Thr Val Ala Leu Ile Glu Ala Val Ala Val 
            500                 505                 510         


Ser Trp Phe Tyr Gly Ile Thr Gln Phe Cys Arg Asp Val Lys Glu Met 
        515                 520                 525             


Leu Gly Phe Ser Pro Gly Trp Phe Trp Arg Ile Cys Trp Val Ala Ile 
    530                 535                 540                 


Ser Pro Leu Phe Leu Leu Phe Ile Ile Cys Ser Phe Leu Met Ser Pro 
545                 550                 555                 560 


Pro Gln Leu Arg Leu Phe Gln Tyr Asn Tyr Pro Tyr Trp Ser Ile Ile 
                565                 570                 575     


Leu Gly Tyr Cys Ile Gly Thr Ser Ser Phe Ile Cys Ile Pro Thr Tyr 
            580                 585                 590         


Ile Ala Tyr Arg Leu Ile Ile Thr Pro Gly Thr Phe Lys Glu Arg Ile 
        595                 600                 605             


Ile Lys Ser Ile Thr Pro Glu Thr Pro Thr Glu Ile Pro Cys Gly Asp 
    610                 615                 620                 


Ile Arg Leu Asn Ala Val 
625                 630 


<210>  55
<211>  2446
<212>  DNA
<213>  Homo sapiens

<400>  55
aaggtataag gtgaggccat aaacagaaag gtatgcaatg agagtagagg ctgcagaaaa       60

ggggaggaaa tagaatgtca gaaaggtcaa gaagagtggt ttaggactga gactgtaagt      120

aatgtaagga ttgccaagga atggttttta tgcagagtca gctgtgtagc acagggagta      180

agcagtcctg ttataaatgg gtgaagctga actccaaaat acaaacttat gtctctttaa      240

tttgcccctt tcctccctct agtcactaaa tgaagatgtt cttcaagttt ctgtctttgc      300

acttctactc tttttgccat ctcttcatgg ggaatgtcac ccagatacat gacttcagtt      360

cttattttga atgactcctc tatttgcagt tataaccctg acatctttct tgaatttttt      420

tgccccttaa ttccaacgaa ctcctggatg tctatgtaga tgtctcataa tttaggccaa      480

tgctgtacaa cttcatgtgg catcatccac atagaatgaa taggggttgt tcaatatgac      540

agccctgcca agcatctcaa attgaacagg tctataaagg aactcagaat cacttgaata      600

tcacagtcca tcagcttcct ttcccagtaa tttaatttcc attaatggta tattaaacat      660

cgtattttca atcattttta ggtttagtca gctacttaaa aataggcttt ttcttcacat      720

aaataaattg tataccattt aatgtgtttt atttcaacag actaatagat cttttaacac      780

ttcttagtcc tcaaaataaa ttattaaaaa ctttgtattt catgtcatat tatataagga      840

aatagaattt tgaagaataa ttcatgctgt tttaaatttt tacattgtac attttaatag      900

ctaatcaact cttaagtata catttgatgg taaatagatg ctagctaatc tagaatcatt      960

tgaaatattg attatctgat ttatagtttg gttgcaagga aatctactgt aagcaaatca     1020

taatagatag caaatcttag aacatgtaga aaaaaagaaa ttaaaaaaag caaatcttag     1080

aacatgtaga aaaaggaaat taaaaaatag atagcaaata acacaaatta tgcatactat     1140

atgtggttat tttcatacaa ctttgataac ggtgaagaat catacttatt gaattttaaa     1200

atgatgatgt ttaaaatcac tctatgacta aagcacatga gaataaatgt taaaggcaca     1260

gccttataat ccacaacttc agaacaatgg aatttttttt tttttttttt tttttttttt     1320

tttttttttt tttttgagac ggagtcttgc tctgtcgccc aggctggagt gcagtggtgc     1380

gatcttggct cactgcaagc tccacctccc aggttcacgg cattctcctg cctctgtctc     1440

ctgagtagct gggactacag gcgcccgcca ccacgtccgg ctcatttttt gtatttttag     1500

tagagacaag gtttcaccgt gttagccagg atggtttcaa tctcctgaca ttgtgatctg     1560

cccacctcgg cctcccaaag tgctgggatt acaggcgtga gccactgcac ccggccaaac     1620

attggaaatt tttaatgatg gatttcagtt cttctcacct ctgggtattt gtaatatttg     1680

gtaaatcagg agtcctgaga gtcttagaat tttcatgcat tttaaatata tgtcttcaaa     1740

gcacctagga atatgtaaat agttacccaa atgtgagaac agaattgaac taaaagcttc     1800

gtttataatt tttttttttt tttgagacag agtctcactc tgttgcccag gctggagcgc     1860

agttgcgtga tttcagctcg ctgcaacctg ggactgcagg cgtgcttcac catgccccgc     1920

taatttttgt ttttttagta gagatggggt ttcgccatgt tggccaggct ggtctcgaac     1980

ttctgaccgc aggtgatcca tccgcctcgg cctcccaaag tgctgggatt acaagcatga     2040

gccaccatgc ccagccggtt aataattctt aatcagtaaa tcattattca aagacatagt     2100

taatatcttc atgacttctt aaggatgctc aaaagctggt cttcagaata cctacatttc     2160

tttatctaca tattctgtca tttggagtta tacaagtagt aatgacacac caaaatgtaa     2220

ataattattg ttagctttta agttggcttc caaattcaaa aaagaaaaaa atcctgaatt     2280

ctctaaagga acatatgata gagtccatat gttaattcat aggaagtgtt taaggtacta     2340

tggtctattt tggtctaatc tttgttttac tatgtaatat atatttatga tttacaagtt     2400

tgttattcag tgggataata aatgaacaca aaatttatgt tctcaa                    2446


<210>  56
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ile Glu Asp Asn Lys Glu Asn Lys Asp His Ser Leu Glu Arg Gly 
1               5                   10                  15      


Arg Ala Ser Leu Ile Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Ile 
            20                  25                  30          


Lys Ala Leu Lys Ile Phe Gln Glu Lys His Val Asn Leu Leu His Ile 
        35                  40                  45              


Glu Ser Arg Lys Ser Lys Arg Arg Asn Ser Glu Phe Glu Ile Phe Val 
    50                  55                  60                  


Asp Cys Asp Ile Asn Arg Glu Gln Leu Asn Asp Ile Phe His Leu Leu 
65                  70                  75                  80  


Lys Ser His Thr Asn Val Leu Ser Val Asn Leu Pro Asp Asn Phe Thr 
                85                  90                  95      


Leu Lys Glu Asp Gly Met Glu Thr Val Pro Trp Phe Pro Lys Lys Ile 
            100                 105                 110         


Ser Asp Leu Asp His Cys Ala Asn Arg Val Leu Met Tyr Gly Ser Glu 
        115                 120                 125             


Leu Asp Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Lys Arg 
    130                 135                 140                 


Arg Lys Tyr Phe Ala Asp Leu Ala Met Asn Tyr Lys His Gly Asp Pro 
145                 150                 155                 160 


Ile Pro Lys Val Glu Phe Thr Glu Glu Glu Ile Lys Thr Trp Gly Thr 
                165                 170                 175     


Val Phe Gln Glu Leu Asn Lys Leu Tyr Pro Thr His Ala Cys Arg Glu 
            180                 185                 190         


Tyr Leu Lys Asn Leu Pro Leu Leu Ser Lys Tyr Cys Gly Tyr Arg Glu 
        195                 200                 205             


Asp Asn Ile Pro Gln Leu Glu Asp Val Ser Asn Phe Leu Lys Glu Arg 
    210                 215                 220                 


Thr Gly Phe Ser Ile Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp 
225                 230                 235                 240 


Phe Leu Ser Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Val 
                245                 250                 255     


Arg His Ser Ser Asp Pro Phe Tyr Thr Pro Glu Pro Asp Thr Cys His 
            260                 265                 270         


Glu Leu Leu Gly His Val Pro Leu Leu Ala Glu Pro Ser Phe Ala Gln 
        275                 280                 285             


Phe Ser Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Glu Glu Ala 
    290                 295                 300                 


Val Gln Lys Leu Ala Thr Cys Tyr Phe Phe Thr Val Glu Phe Gly Leu 
305                 310                 315                 320 


Cys Lys Gln Asp Gly Gln Leu Arg Val Phe Gly Ala Gly Leu Leu Ser 
                325                 330                 335     


Ser Ile Ser Glu Leu Lys His Ala Leu Ser Gly His Ala Lys Val Lys 
            340                 345                 350         


Pro Phe Asp Pro Lys Ile Thr Cys Lys Gln Glu Cys Leu Ile Thr Thr 
        355                 360                 365             


Phe Gln Asp Val Tyr Phe Val Ser Glu Ser Phe Glu Asp Ala Lys Glu 
    370                 375                 380                 


Lys Met Arg Glu Phe Thr Lys Thr Ile Lys Arg Pro Phe Gly Val Lys 
385                 390                 395                 400 


Tyr Asn Pro Tyr Thr Arg Ser Ile Gln Ile Leu Lys Asp Thr Lys Ser 
                405                 410                 415     


Ile Thr Ser Ala Met Asn Glu Leu Gln His Asp Leu Asp Val Val Ser 
            420                 425                 430         


Asp Ala Leu Ala Lys Val Ser Arg Lys Pro Ser Ile 
        435                 440                 


<210>  57
<211>  2360
<212>  DNA
<213>  Homo sapiens

<400>  57
gcattgctct tcagcaccag ggttctggac agcgccccaa gcaggcagct gatcgcacgc       60

cccttcctct caatctccgc cagcgctgct actgcccctc tagtaccccc tgctgcagag      120

aaagaatatt acaccgggat ccatgcagcc agcaatgatg atgttttcca gtaaatactg      180

ggcacggaga gggttttccc tggattcagc agtgcccgaa gagcatcagc tacttggcag      240

ctcaacacta aataaaccta actctggcaa aaatgacgac aaaggcaaca agggaagcag      300

caaacgtgaa gctgctaccg aaagtggcaa gacagcagtt gttttctcct tgaagaatga      360

agttggtgga ttggtaaaag cactgaggct ctttcaggaa aaacgtgtca acatggttca      420

tattgaatcc aggaaatctc ggcgaagaag ttctgaggtt gaaatctttg tggactgtga      480

gtgtgggaaa acagaattca atgagctcat tcagttgctg aaatttcaaa ccactattgt      540

gacgctgaat cctccagaga acatttggac agaggaagaa gagctagagg atgtgccctg      600

gttccctcgg aagatctctg agttagacaa atgctctcac agagttctca tgtatggttc      660

tgagcttgat gctgaccacc caggatttaa ggacaatgtc tatcgacaga gaagaaagta      720

ttttgtggat gtggccatgg gttataaata tggtcagccc attcccaggg tggagtatac      780

tgaagaagaa actaaaactt ggggtgttgt attccgggag ctctccaaac tctatcccac      840

tcatgcttgc cgagagtatt tgaaaaactt ccctctgctg actaaatact gtggctacag      900

agaggacaat gtgcctcaac tcgaagatgt ctccatgttt ctgaaagaaa ggtctggctt      960

cacggtgagg ccggtggctg gatacctgag cccacgagac tttctggcag gactggccta     1020

cagagtgttc cactgtaccc agtacatccg gcatggctca gatcccctct acaccccaga     1080

accagacaca tgccatgaac tcttgggaca tgttccacta cttgcggatc ctaagtttgc     1140

tcagttttca caagaaatag gtctggcgtc tctgggagca tcagatgaag atgttcagaa     1200

actagccacg tgctatttct tcacaatcga gtttggcctt tgcaagcaag aagggcaact     1260

gcgggcatat ggagcaggac tcctttcctc cattggagaa ttaaagcacg ccctttctga     1320

caaggcatgt gtgaaagcct ttgacccaaa gacaacttgc ttacaggaat gccttatcac     1380

caccttccag gaagcctact ttgtttcaga aagttttgaa gaagccaaag aaaagatgag     1440

ggactttgca aagtcaatta cccgtccctt ctcagtatac ttcaatccct acacacagag     1500

tattgaaatt ctgaaagaca ccagaagtat tgaaaatgtg gtgcaggacc ttcgcagcga     1560

cttgaataca gtgtgtgatg ctttaaacaa aatgaaccaa tatctgggga tttgatgcct     1620

ggaactatgt tgttgccagc atgatctttt tggggcttag cagcagttca gtcaatgtca     1680

tataacgcaa ataaccttct gtgtcatggc ttggctaata agcatgcaat tccatatatc     1740

tataccatct tgtaactcac tgtgttagta tataaagcac cataagaaat ccaatggcag     1800

ataaccactc attgtatgaa ataacgtatt atgtttaaac atcttaaaaa gatttgacat     1860

tcctgcttag tgtccttaac caaactgcat ctagttaaaa tttgtaacaa atagccctct     1920

tatgagtctc atttatgccc ttttcttttt cagatctaag cctttcctct gtgttcatta     1980

gataaaatga aaaaaagcag tgaagctgtt tccattttca atagtatcag tgttttcacg     2040

cattatttga gataaaccca gaattgtagg aaacttccca tcacaataac aaaggttcaa     2100

tattctattt caaaaattgt tgaggtaaca cagcagttgg aatgattttt aggttgagta     2160

tttacacaat gcaagaaaac acctttttac aaatggaatt atgtaggttg cgttgacctt     2220

gtagaacctg agttatgaca agcttcctga agtattttgg aagatagtac ttccggaaag     2280

gacattagga aagactaaac agtggacaat caatcttggg actatgaatt ttatgctgga     2340

ataaagtaaa ttatcatgtt                                                 2360


<210>  58
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gln Pro Ala Met Met Met Phe Ser Ser Lys Tyr Trp Ala Arg Arg 
1               5                   10                  15      


Gly Phe Ser Leu Asp Ser Ala Val Pro Glu Glu His Gln Leu Leu Gly 
            20                  25                  30          


Ser Ser Thr Leu Asn Lys Pro Asn Ser Gly Lys Asn Asp Asp Lys Gly 
        35                  40                  45              


Asn Lys Gly Ser Ser Lys Arg Glu Ala Ala Thr Glu Ser Gly Lys Thr 
    50                  55                  60                  


Ala Val Val Phe Ser Leu Lys Asn Glu Val Gly Gly Leu Val Lys Ala 
65                  70                  75                  80  


Leu Arg Leu Phe Gln Glu Lys Arg Val Asn Met Val His Ile Glu Ser 
                85                  90                  95      


Arg Lys Ser Arg Arg Arg Ser Ser Glu Val Glu Ile Phe Val Asp Cys 
            100                 105                 110         


Glu Cys Gly Lys Thr Glu Phe Asn Glu Leu Ile Gln Leu Leu Lys Phe 
        115                 120                 125             


Gln Thr Thr Ile Val Thr Leu Asn Pro Pro Glu Asn Ile Trp Thr Glu 
    130                 135                 140                 


Glu Glu Glu Leu Glu Asp Val Pro Trp Phe Pro Arg Lys Ile Ser Glu 
145                 150                 155                 160 


Leu Asp Lys Cys Ser His Arg Val Leu Met Tyr Gly Ser Glu Leu Asp 
                165                 170                 175     


Ala Asp His Pro Gly Phe Lys Asp Asn Val Tyr Arg Gln Arg Arg Lys 
            180                 185                 190         


Tyr Phe Val Asp Val Ala Met Gly Tyr Lys Tyr Gly Gln Pro Ile Pro 
        195                 200                 205             


Arg Val Glu Tyr Thr Glu Glu Glu Thr Lys Thr Trp Gly Val Val Phe 
    210                 215                 220                 


Arg Glu Leu Ser Lys Leu Tyr Pro Thr His Ala Cys Arg Glu Tyr Leu 
225                 230                 235                 240 


Lys Asn Phe Pro Leu Leu Thr Lys Tyr Cys Gly Tyr Arg Glu Asp Asn 
                245                 250                 255     


Val Pro Gln Leu Glu Asp Val Ser Met Phe Leu Lys Glu Arg Ser Gly 
            260                 265                 270         


Phe Thr Val Arg Pro Val Ala Gly Tyr Leu Ser Pro Arg Asp Phe Leu 
        275                 280                 285             


Ala Gly Leu Ala Tyr Arg Val Phe His Cys Thr Gln Tyr Ile Arg His 
    290                 295                 300                 


Gly Ser Asp Pro Leu Tyr Thr Pro Glu Pro Asp Thr Cys His Glu Leu 
305                 310                 315                 320 


Leu Gly His Val Pro Leu Leu Ala Asp Pro Lys Phe Ala Gln Phe Ser 
                325                 330                 335     


Gln Glu Ile Gly Leu Ala Ser Leu Gly Ala Ser Asp Glu Asp Val Gln 
            340                 345                 350         


Lys Leu Ala Thr Cys Tyr Phe Phe Thr Ile Glu Phe Gly Leu Cys Lys 
        355                 360                 365             


Gln Glu Gly Gln Leu Arg Ala Tyr Gly Ala Gly Leu Leu Ser Ser Ile 
    370                 375                 380                 


Gly Glu Leu Lys His Ala Leu Ser Asp Lys Ala Cys Val Lys Ala Phe 
385                 390                 395                 400 


Asp Pro Lys Thr Thr Cys Leu Gln Glu Cys Leu Ile Thr Thr Phe Gln 
                405                 410                 415     


Glu Ala Tyr Phe Val Ser Glu Ser Phe Glu Glu Ala Lys Glu Lys Met 
            420                 425                 430         


Arg Asp Phe Ala Lys Ser Ile Thr Arg Pro Phe Ser Val Tyr Phe Asn 
        435                 440                 445             


Pro Tyr Thr Gln Ser Ile Glu Ile Leu Lys Asp Thr Arg Ser Ile Glu 
    450                 455                 460                 


Asn Val Val Gln Asp Leu Arg Ser Asp Leu Asn Thr Val Cys Asp Ala 
465                 470                 475                 480 


Leu Asn Lys Met Asn Gln Tyr Leu Gly Ile 
                485                 490 


<210>  59
<211>  2406
<212>  DNA
<213>  Homo sapiens

<400>  59
ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag ctgtattcct       60

ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt acattttgct      120

aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc agatggactt      180

gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa aattttttat      240

aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg ttcgctcttg      300

gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc attcactgcc      360

ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact cttgctctca      420

ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct gcttgggcat      480

cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat tccatcacat      540

cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc cataatatgc      600

tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt atttattgtg      660

tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct acttttgcca      720

aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc atctgtgtag      780

ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc tgcttagttc      840

tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat agctagagct      900

tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc taggtacata      960

agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag ggtgagcttg     1020

agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt tttttttttt     1080

ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc tcctggaaac     1140

tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca gggctatccc     1200

gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt gaccaccaaa     1260

ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat ctcagtaata     1320

aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt attcaaaaat     1380

ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt gttggaaact     1440

ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg ttgagggatt     1500

tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca tcacctgctg     1560

gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa ctttgaagag     1620

atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc ttaattaaga     1680

tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag catttgtact     1740

aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg actggtgaga     1800

gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca ttgttgagaa     1860

ttagatccca catcgtataa atatctatta accattctaa ataaagagaa ctccagtgtt     1920

gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt gtgctatttg     1980

tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc tgtgttaccg     2040

ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa gctttgaata     2100

tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt gtaaatatta     2160

ccctgtaata ttatatatac ttaataaaac attttaagct attttgttgg gctatttcta     2220

ttgctgctac agcagaccac aagcacattt ctgaaaaatt taatttatta atgtattttt     2280

aagttgctta tattctaggt aacaatgtaa agaatgattt aaaatattaa ttatgaattt     2340

tttgagtata atacccaata agcttttaat tagagcagag ttttaattaa aagttttaaa     2400

tcagtc                                                                2406


<210>  60
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  61
<211>  2429
<212>  DNA
<213>  Homo sapiens

<400>  61
cagcttctgg gggtagatct caatttgcag tattcagact tctttttctt tcttttacat       60

tcttttttct ttctttcttt ctgccaactt tgttttccag tgtttacaag gtgacaaatg      120

tttgactttg gttgtgttta aatgtccgtg taaaatagct gccttttatt ttttaaggta      180

acaaatacca cctagaggta ggtaggatca tcccacgctt gctttagcac aggacaactt      240

tacaaaacat gattgtttac agctgctctt cccctctttt ctgatctgca gtttttgcct      300

gggtcccact caggtgaaaa tccatctcat tctggaatgg ttttgctttt gaatttttgg      360

ttatttttgt gtttctttgg gggttagacc actttctgat tagccgccac ctgcctgcat      420

ctgtgaaaag ggatctgctc ccaggcgttc tcacccttct tttgaaggac tccttaggct      480

ttgttgaatg aagcagagaa gattgtatag ttggggctgg tcttggtgaa cacacattat      540

taccccacac atcccctttg tgtagaaagc caaataaaat ctatacatac catttccttt      600

tgagcccaga atctagattt gagcggaaga gcatgtgtgc ttcagggaat tagtgtcttt      660

ttttggaaat ctgttgaagt aaagtaacat cggccttctg ttcacttagg cagcatttat      720

agaaacaaaa gaagaaagaa acaacctact gtctggagtc ataacacaac tttcctggat      780

tggaaaccaa gtgggggaaa aaatacagaa actttaaggg ggatgggagg ggggggagaa      840

gggaaaagcc agccctttgt atagaaattt tgcttttttt tccctcattc tactttagaa      900

ctgcaagctt gtgcactgtg gatgcgtgaa tattttagtg tgaaacgtgt ttttgtcata      960

gtattgaaat aaaacttcaa catagtttgg ttgtggaagg tatagcagat agttcagaaa     1020

aaatattcag gaaacaaaaa tcactcaaac ggaatcgaag ccttttaaca aagaaaatga     1080

aatacagatg atgatgatga tgatgaagat gatgctaagt aaacagaaat cagtactccg     1140

catgcgctcc tctcctaagg tacaaagcag caagaggtta gggtggcaag gctgcctctg     1200

ggtccattct gtgggccact ctccccaacg ttctgacact tctgcagtct gatcagtggc     1260

gatgctagat tataatttca aactgtgaag aataatggtc ttgtcatttg ctcaatgtgg     1320

ggttatgttg cattttctca gctcctgggg atggaaatgg aggatcccag aacacacagc     1380

cctggcccct ttgattctag ggcctgcaca gatctctggt tcaaatgcac aggccctcag     1440

aatagaggaa catgaagaga gatcttagag cacacagtag aatgtgagag cctgggtgtc     1500

tgagaccggg agggcccagc agtgaggggc aggctcttct ggtcaccagg ctgttcagtg     1560

gactcagttc ttcatcttgt aatgtcgatg gctttgccac accaggccaa gcccatgcca     1620

taccttgtca agactgtcaa agtggttgtg gttaggtcaa actggttttg gttctgatgg     1680

ttaggaagaa acaggtcagc cctcagatca cctggcccgg gacagctgac cccctagaac     1740

cctggctctg ccattagcta ggacctaaga ctctgcccac attttggtct gttctctccc     1800

attacacata ggtttgtctc agcatgcaag agtttttcct ttaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaag caatgctttc tctaaaatca aagagggagt cattttattc caagatgttt     1920

tatcttttat gttaagagat caaagcttat aattttcttt tttaattttt gaaggaggga     1980

tcaactccag tttccaatgt ctatgtgtct atgtgtgtat gtgccataca tatgtattca     2040

catgaagacc ggcatggcca agttctgctg gaggagcact caagtgtgac gagcagggcc     2100

actggaccct gcagggctgt ggtgtatata gtgcagcttt ggaggtggaa ctctattttc     2160

acacttttct atggagcctt ccgagtccca ggttttcact tgaggctgtc tgtctggatg     2220

gcggttttca gacctccatt aacatcccta cccagcattc tgtacttcgg gggccttctc     2280

tcttgttata aaacttttta ccaagtgaaa catcgatacc acctttgttt ccattctcac     2340

tggtgtaaat actgagtact aactgagaat tttgactttg cattctgtcg gaatacttgt     2400

gttcaataaa aattgaaaga aaaaagcta                                       2429


<210>  62
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  63
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  63
gggccgccgg ctgccagccc agggcggggc ggagccctac ttctggccga ccgcgtaggc       60

ggtgcttgaa cttagggctg cttgtggctg ggcactcgcg cagaggccgg cccgacgagc      120

catggttgct gggagcgacg cggggcgggc cctgggggtc ctcagcgtgg tctgcctgct      180

gcactgcttt ggtttcatca gctgtttttc ccaacaaata tatggtgttg tgtatgggaa      240

tgtaactttc catgtaccaa gcaatgtgcc tttaaaagag gtcctatgga aaaaacaaaa      300

ggataaagtt gcagaactgg aaaattctga attcagagct ttctcatctt ttaaaaatag      360

ggtttattta gacactgtgt caggtagcct cactatctac aacttaacat catcagatga      420

agatgagtat gaaatggaat cgccaaatat tactgatacc atgaagttct ttctttatgt      480

gcttgagtct cttccatctc ccacactaac ttgtgcattg actaatggaa gcattgaagt      540

ccaatgcatg ataccagagc attacaacag ccatcgagga cttataatgt actcatggga      600

ttgtcctatg gagcaatgta aacgtaactc aaccagtata tattttaaga tggaaaatga      660

tcttccacaa aaaatacagt gtactcttag caatccatta tttaatacaa catcatcaat      720

cattttgaca acctgtatcc caagcagcgg tcattcaaga cacagatatg cacttatacc      780

cataccatta gcagtaatta caacatgtat tgtgctgtat atgaatggta ttctgaaatg      840

tgacagaaaa ccagacagaa ccaagtaagt acactgcagg ctgtgcactc tgtgccagaa      900

caacagcagc cctgctgtag atgcccatta cttgggaagc cagattgtac tcatctgttg      960

gttgccttgt acagtaataa gaagtaacat cagcagatat actaaccata gtgtattaag     1020

taccaactgt gtgccatgca ctgcactagc cactctctgc atatcgtttc ctggaaccct     1080

ctcaatgagc cttgcaggag gagtatcata ccccttgctt agagacagcg catatgagat     1140

tcatagaagt caagtgagat atcaaagtca cgttgctagt aagtgatggg ctgggattta     1200

aatctaggtc tttggactcc aagagttata ctgttaacca ctacaataca ctccctccac     1260

ctcccatccc agaaaaagtt ggatcaggga tagggttcac ttcaggagcc agggtcagag     1320

ctgggcctgt agtcacatat aaaagatagg acacaaacac aattagcagc agtgttggtt     1380

taataaaccg ccgta                                                      1395


<210>  64
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Lys 
                245             


<210>  65
<211>  7563
<212>  DNA
<213>  Homo sapiens

<400>  65
agaagcggct cgaggctgga agaggatctt gggcgccgcc aggttctgtg gacaatcaca       60

atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc      120

cattcaggtc atagcctgca gtgctacaac tgtcctaacc caactgctga ctgcaaaaca      180

gccgtcaatt gttcatctga ttttgatgcg tgtctcatta ccaaagctgg gttacaagtg      240

tataacaagt gttggaagtt tgagcattgc aatttcaacg acgtcacaac ccgcttgagg      300

gaaaatgagc taacgtacta ctgctgcaag aaggacctgt gtaactttaa cgaacagctt      360

gaaaatggtg ggacatcctt atcagagaaa acagttcttc tgctggtgac tccatttctg      420

gcagcagcct ggagccttca tccctaagtc aacaccagga gagcttctcc caaactcccc      480

gttcctgcgt agtccgcttt ctcttgctgc cacattctaa aggcttgata ttttccaaat      540

ggatcctgtt gggaaagaat aaaattagct tgagcaacct ggctaagata gaggggctct      600

gggagacttt gaagaccagt cctgtttgca gggaagcccc acttgaagga agaagtctaa      660

gagtgaagta ggtgtgactt gaactagatt gcatgcttcc tcctttgctc ttgggaagac      720

cagctttgca gtgacagctt gagtgggttc tctgcagccc tcagattatt tttcctctgg      780

ctccttggat gtagtcagtt agcatcatta gtacatcttt ggagggtggg gcaggagtat      840

atgagcatcc tctctcacat ggaacgcttt cataaacttc agggatcccg tgttgccatg      900

gaggcatgcc aaatgttcca tatgtgggtg tcagtcaggg acaacaagat ccttaatgca      960

gagctagagg acttctggca gggaagtggg gaagtgttcc agatagcagg gcatgaaaac     1020

ttagagaggt acaagtggct gaaaatcgag tttttcctct gtctttaaat tttatatggg     1080

ctttgttatc ttccactgga aaagtgtaat agcatacatc aatggtgtgt taaagctatt     1140

tccttgcctt ttttttattg gaatggtagg atatcttggc tttgccacac acagttacag     1200

agtgaacact ctactacatg tgactggcag tattaagtgt gcttatttta aatgttactg     1260

gtagaaaggc agttcaggta tgtgtgtata tagtatgaat gcagtgggga caccctttgt     1320

ggttacagtt tgagacttcc aaaggtcatc cttaataaca acagatctgc aggggtatgt     1380

tttaccatct gcatccagcc tcctgctaac tcctagctga ctcagcatag attgtataaa     1440

atacctttgt aacggctctt agcacactca cagatgtttg aggctttcag aagctcttct     1500

aaaaaatgat acacaccttt cacaagggca aactttttcc ttttccctgt gtattctagt     1560

gaatgaatct caagattcag tagacctaat gacatttgta ttttatgatc ttggctgtat     1620

ttaatggcat aggctgactt ttgcagatgg aggaatttct tgattaatgt tgaaaaaaaa     1680

cccttgatta tactctgttg gacaaaccga gtgcaatgaa tgatgctttt ctgaaaatga     1740

aatataacaa gtgggtgaat gtggttatgg ccgaaaagga tatgcagtat gcttaatggt     1800

agcaactgaa agaagacatc ctgagcagtg ccagctttct tctgttgatg ccgttccctg     1860

aacataggaa aatagaaact tgcttatcaa aacttagcat taccttggtg ctctgtgttc     1920

tctgttagct cagtgtcttt ccttacatca ataggttttt tttttttttt ttggcctgag     1980

gaagtactga ccatgcccac agccaccggc tgagcaaaga agctcatttc atgtgagttc     2040

taaggaatga gaaacaattt tgatgaattt aagcagaaaa tgaatttctg ggaacttttt     2100

tgggggcggg ggggtgggga attcagccac actccagaaa gccaggagtc gacagttttg     2160

gaagcctctc tcaggattga gattctagga tgagattggc ttactgctat cttgtgtcat     2220

gtacccactt tttggccaga ctacactggg aagaaggtag tcctctaaag caaaatctga     2280

gtgccactaa atggggagat ggggctgtta agctgtccaa atcaacaagg gtcatataaa     2340

tggccttaaa ctttggggtt gctttctgca aaaagttgct gtgactcatg ccatagacaa     2400

ggttgagtgc ctggacccaa aggcaatact gtaatgtaaa gacatttata gtactaggca     2460

aacagcaccc caggtactcc aggccctcct ggctggagag ggctgtggca atagaaaatt     2520

agtgccaact gcagtgagtc agcctaggtt aaatagagag tgtaagagtg ctggacagga     2580

acctccaccc tcatgtcaca tttcttcaat gtgacccttc tggcccctct cctcctgaca     2640

gcggaacaat gactgccccg ataggtgagg ctggaggaag aatcagtcct gtccttggca     2700

agctcttcac tatgacagta aaggctctct gcctgctgcc aaggcctgtg actttctaac     2760

ctggcctcac gctgggtaag cttaaggtag aggtgcagga ttagcaagcc cacctggcta     2820

ccaggccgac agctacatcc tccaactgac cctgatcaac gaagagggat tcatgtgtct     2880

gtctcagttg gttccaaatg aaaccaggga gcaggggagt taggaatcga acaccagtca     2940

tgcctactgg ctctctgctc gagagccaat accctgtgcc ctccactcat ctggatttac     3000

aggaactgtc atagtgttca gtattgggtg gtgataagcc cattggattg tccccttggg     3060

gggatgagct aggggtgcaa ggaacacctg atgagtagat aagtggagct catggtattt     3120

cctgaaagat gctaatctat ttgccaaact tggtcttgaa tgtactgggg gcttcaaggt     3180

atgggtatat ttttcttgtg tccttgcagt tagcccccat gtcttatgtg tgtcctgaaa     3240

aaataagagc ctgcccaaga ctttgggcct cttgacagaa ttaaccactt ttatacatct     3300

gagttctctt ggtaagttct ttagcagtgt tcaaagtcta ctagctcgca ttagtttctg     3360

ttgctgccaa cagatctgaa ctaatgctaa cagatccccc tgagggattc ttgatgggct     3420

gagcagctgg ctggagctag tactgactga cattcattgt gatgagggca gctttctggt     3480

acaggattct aagctctatg ttttatatac attttcatct gtacttgcac ctcactttac     3540

acaagaggaa actatgcaaa gttagctgga tcgctcaagg tcacttaggt aagttggcaa     3600

gtccatgctt cccactcagc tcctcaggtc agcaagtcta cttctctgcc tattttgtat     3660

actctcttta atatgtgcct agctttggaa agtctagaat gggtccctgg tgccttttta     3720

ctttgaagaa atcagtttct gcctcttttt ggaaaagaaa acaaagtgca attgtttttt     3780

actggaaagt tacccaatag catgaggtga acaggacgta gttaggcctt cctgtaaaca     3840

gaaaatcata tcaaaacact atcttcccat ctgtttctca atgcctgcta cttcttgtag     3900

atatttcatt tcaggagagc agcagttaaa cccgtggatt ttgtagttag gaacctgggt     3960

tcaaaccctc ttccactaat tggctatgtc tctggacaag tttttttttt tttttttttt     4020

taaacccttt ctgaactttc actttctatg tctacctcaa agaattgttg tgaggcttga     4080

gataatgcat ttgtaaaggg tctgccagat aggaagatgc tagttatgga tttacaaggt     4140

tgttaaggct gtaagagtct aaaacctaca gtgaatcaca atgcatttac ccccactgac     4200

ttggacataa gtgaaaacta gccagaagtc tctttttcaa attacttaca ggttattcaa     4260

tataaaattt ttgtaatgga taatcttatt tatctaaact aaagcttcct gtttatacac     4320

actcctgtta ttctgggata agataaatga ccacagtacc ttaatttcta ggtgggtgcc     4380

tgtgatggtt cattgtaggt aaggacattt tctctttttc agcagctgtg taggtccaga     4440

gcctctggga gaggaggggg gtagcatgca cccagcaggg gactgaactg ggaaactcaa     4500

ggttcttttt actgtggggt agtgagctgc ctttctgtga tcggtttccc tagggatgtt     4560

gctgttcccc tccttgctat tcgcagctac atacaacgtg gccaacccca gtaggctgat     4620

cctatatatg atcagtgctg gtgctgactc tcaatagccc cacccaagct ggctataggt     4680

ttacagatac attaattagg caacctaaaa tattgatgct ggtgttggtg tgacataatg     4740

ctatggccag aactgaaact tagagttata attcatgtat tagggttctc cagagggaca     4800

gaattagtag gatatatgta tatatgaaag ggaggttatt agggagaact ggctcccaca     4860

gttagaaggc gaagtcgcac aataggccgt ctgcaagctg ggttagagag aagccagtag     4920

tggctcagcc tgagttcaaa aacctcaaaa ctggggaagc tgacagtgca gccagccttc     4980

agtctgtggc caaaggccca agagcccctg gcaaccaacc cactggtgca agtcctagat     5040

tccaaaggct gaagaacctg gagtctgatg tccaagagca ggaagagtgg aagaaagcca     5100

gaagactcag caaacaaggt agacagtgtc taccaccata gtggccatac caaagaggct     5160

accgattcct tcctgctacc tggatccctg aagttgccct ggtctctgca ccttctaaac     5220

ctagttctta agagctttcc attacatgag ctgtctcaaa gccctccaat aaattctcag     5280

tgtaagcttc tgttgcttgt ggacagaaaa ttctgacaga cctaccctat aagtgttact     5340

gtcaggataa catgagaacg cacaacagta agtggtcact aagtgttagc tacggttatt     5400

ttgcccaagg tagcatggct agttgatgcc ggttgatggg gcttaaaccc agctccctca     5460

tcttccaggc ctctgtactc cctattccac taaactacct ctcaggttta tttttttaaa     5520

ttcttactct gcaagtacat aggaccacat ttacctggga aaacaagaat aaaggctgct     5580

ctgcattttt tagaaacttt tttgaaaggg agatgggaat gcctgcaccc ccaagtccag     5640

accaacacaa tggttaattg agatgaataa taaaggaaag actgttctgg gcttcccaga     5700

atagcttggt ccttaaattg tggcacaaac aacctcctgt cagagccagc ctcctgccag     5760

gaagaggggt aggagactag aggccgtgtg tgcagccttg ccctgaaggc tagggtgaca     5820

atttggaggc tgtccaaaca ccctggcctc tagagctggc ctgtctattt gaaatgccgg     5880

ctctgatgct aatcggcgac cctcaggcaa gttacttaac cttacatgcc tcagttttct     5940

catctggaaa atgagaaccc taggtttagg gttgttagaa aagttaaatg agttaagaca     6000

agtgcctggg acacagtagc ctcttgtgtg tgtttatcat tatgtcctca gcaggtcgta     6060

gaagcagctt ctcaggtgtg aggctggcgc gattatctgg agtgggttgg gttttctagg     6120

atggaccccc tgctgcattt tcctcattca tccaccaggg cttaatgggg aatcaaggaa     6180

tccatgtgta actgtataat aactgtagcc acactccaat gaccacctac tagttgtccc     6240

tggcactgct tatacatatg tccatcaaat caatcctatg aagtagatac tgtcttcatt     6300

ttatagatca gagacaattg gggttcagag agctgatgtg attttcccag ggtcacagag     6360

agtcccagat tcaggcacaa ctcttgtatt ccaagacaca accactacat gtccaaaggc     6420

tgcccagagc caccgggcac ggcaaattgt gacatatccc taaagaggct gagcacctgg     6480

tcaggatctg atggctgaca gtgtgtccag atgcagagct ggagtggggg aggggaaggg     6540

gggctccttg ggacagagaa ggctttctgt gctttctctg aagggagcag tctgaggacc     6600

aagggaaccc ggcaaacagc acctcaggta ctccaggccc tcctggctgg agagggctgt     6660

ggcaatggaa aattagtgcc aactgcaatg agtcagcctc ggttaaatag agagtgaaga     6720

atgctggaca ggaacctcca ccctcatgtc acatttcttc agtgtgaccc ttctggcccc     6780

tctcctcctg acagcggaac aatgactgcc ccgataggtg aggctggagg aagaatcagt     6840

cctgtccttg gcaagctctt cactatgaca gtaaaggctc tctgcctgct gccaaggcct     6900

gtgactttct aacctggcct cacgctgggt aagcttaagg tagaggtgca ggattagcaa     6960

gcccacctgg ctaccaggcc gacagctaca tctttcaact gaccctgatc aacgaagagg     7020

gacttgtgtc tctcagttgg ttccaaatga aaccagggag caggggcgtt aggaagctcc     7080

aacaggatgg tacttaatgg ggcatttgag tggagaggta ggtgacatag tgctttggag     7140

cccagggagg gaaaggttct gctgaagttg aattcaagac tgttctttca tcacaaactt     7200

gagtttcctg gacatttgtt tgcagaaaca accgtagggt tttgccttaa cctcgtgggt     7260

ttattattac ctcataggga ctttgcctcc tgacagcagt ttatgggtgt tcattgtggc     7320

acttgagttt tcttgcatac ttgttagaga aaccaagttt gtcatcaact tcttatttaa     7380

ccccctggct ataacttcat ggattatgtt ataattaagc catccagagt aaaatctgtt     7440

tagattatct tggagtaagg gggaaaaaat ctgtaatttt ttctcctcaa ctagatatat     7500

acataaaaaa tgattgtatt gcttcattta aaaaatataa cgcaaaatct cttttccttc     7560

taa                                                                   7563


<210>  66
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  67
<211>  1379
<212>  DNA
<213>  Homo sapiens

<400>  67
tttggttcct tgtggccaca tttccagtac ccagtagtca tctgtgccag ggggttatcc       60

aggtacagaa cattcccatc gttgcagaag gttctatcag ctagcactgg gttggacgac      120

acttgccaag acgagctggc tagaggatgg ttctccggac ctggtcccac gtggttccca      180

gctggctgga ggcgtgatcc tgggtgtggc cctgtggctc cgccatgacc cgcagaccac      240

caacctcctg tatctggagc tgggagacaa gcccgcgccc aacaccttct atgtaggcat      300

ctacatcctc atcgctgtgg gcgctgtcat gatgttcgtt ggcttcctgg gctgctacgg      360

ggccatccag gaatcccagt gcctgctggg gacgttcttc acctgcctgg tcatcctgtt      420

tgcctgtgag gtggccgccg gcatctgggg ctttgtcaac aaggaccaga tcgccaagga      480

tgtgaagcag ttctatgacc aggccctaca gcaggccgtg gtggatgatg acgccaacaa      540

cgccaaggct gtggtgaaga ccttccacga gacgcttgac tgctgtggct ccagcacact      600

gactgctttg accacctcag tgctcaagaa caatttgtgt ccctcgggca gcaacatcat      660

cagcaacctc ttcaaggagg actgccacca gaagatcgat gacctcttct ccgggaagct      720

gtacctcatc ggcattgctg ccatcgtggt cgctgtgatc atgatcttcg agatgatcct      780

gagcatggtg ctgtgctgtg gcatccggaa cagctccgtg tactgaggcc ccgcagctct      840

ggccacaggg acctctgcag tgccccctaa gtgacccgga cacttccgag ggggccatca      900

ccgcctgtgt atataacgtt tccggtatta ctctgctaca cgtagccttt ttacttttgg      960

ggttttgttt ttgttctgaa ctttcctgtt accttttcag ggctgacgtc acatgtaggt     1020

ggcgtgtatg agtggagacg ggcctgggtc ttggggactg gagggcaggg gtccttctgc     1080

cctggggtcc cagggtgctc tgcctgctca gccaggcctc tcctgggagc cactcgccca     1140

gagactcagc ttggccaact tggggggctg tgtccaccca gcccgcccgt cctgtgggct     1200

gcacagctca ccttgttccc tcctgccccg gttcgagagc cgagtctgtg ggcactctct     1260

gccttcatgc acctgtcctt tctaacacgt cgccttcaac tgtaatcaca acatcctgac     1320

tccgtcattt aataaagaag gaacatcagg catgctacca ggcctgtgca gtccctcag      1379


<210>  68
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Met Phe Val Gly Phe Leu Gly Cys Tyr Gly Ala Ile Gln Glu Ser 
1               5                   10                  15      


Gln Cys Leu Leu Gly Thr Phe Phe Thr Cys Leu Val Ile Leu Phe Ala 
            20                  25                  30          


Cys Glu Val Ala Ala Gly Ile Trp Gly Phe Val Asn Lys Asp Gln Ile 
        35                  40                  45              


Ala Lys Asp Val Lys Gln Phe Tyr Asp Gln Ala Leu Gln Gln Ala Val 
    50                  55                  60                  


Val Asp Asp Asp Ala Asn Asn Ala Lys Ala Val Val Lys Thr Phe His 
65                  70                  75                  80  


Glu Thr Leu Asp Cys Cys Gly Ser Ser Thr Leu Thr Ala Leu Thr Thr 
                85                  90                  95      


Ser Val Leu Lys Asn Asn Leu Cys Pro Ser Gly Ser Asn Ile Ile Ser 
            100                 105                 110         


Asn Leu Phe Lys Glu Asp Cys His Gln Lys Ile Asp Asp Leu Phe Ser 
        115                 120                 125             


Gly Lys Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val Ala Val Ile 
    130                 135                 140                 


Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys Cys Gly Ile Arg 
145                 150                 155                 160 


Asn Ser Ser Val Tyr 
                165 


<210>  69
<211>  2384
<212>  DNA
<213>  Homo sapiens

<400>  69
gtgaatctgc gctaagctat gcagtctgct ttttcttctc agctctggta gttcttcaga       60

aatgtaccct ccaggcacat ccactattgc gagggtgagc acgaagggtg ggagatgccc      120

atgtcctcaa ggcatcactt cctaaatcca aaagcatcgg caggagaaag gactggggac      180

aaatactgtc ccttcgggag tagggaggga acactgaggc ccatccctgg ctccttccct      240

aaaagtagag taaaatggaa gcgagcatcc tgggattggg ggcaagaggg ggaccgcagg      300

gtagctgtgg gttccaactg ctgtcagagt cagagaggca gccccaagcc agcctccctg      360

ctttgccagg gaatttgggg gaggaaggtg acagctgccc agaggctgac tcatctgata      420

tttagcactg ggtaggatga ttgtttctga gcatttttct taaaggcctc agatctaaat      480

tatgccaccg gctcccactc ttgctacctc ccgtcaactt ctctgccttg ccttccaccc      540

ctgtagttac catacacaga ggaggaggag ctgtccttgt cccaggttgg gaggctgaca      600

accccttagc aagatgctgc cagcccagag ctctccaagg ggaggaacac ccctgagact      660

caggcccctc tccttcagcc ctgcttgggc tgcaagcgcc gtgccaagga aaggcatctt      720

ggtgagaaga gctgctgtgg gggaagggag atcaaatgcc agagaaatgt ggggtgcccc      780

accctcagga tagtaaaaga gtatggaggt atttctggaa ggaaatgagc ggcactgtgt      840

gaagcctcgc acctgtgtga cacttcctat ggggtctttg tcacactcta gtactatgtc      900

cctgaagagt ttagcagcca cactcttaga agggtgctgg gagatggtgt tgccctctgc      960

agccatgttt aggggagcgg aacctgaggc ccacagtggg tgagattagc tcaagaagcc     1020

acagaggcca ccagagggcc acggacttcg gaaaggagaa gagaagaaca gggcatcagg     1080

cctcacaacg caaacctacc cagagatggg cacagtggct catgcctgta atcccaccac     1140

tttgggaaga ggcggatcgc ttgaggtcag gagttcgaga ctagcctcga aaccctatct     1200

ctactaaaaa tacaaaaatt agccaggcat ggtggcctgc gcctgtaatc ccagctactc     1260

aggaggctga ggcaggagaa tcacttgaac ccgggaggcg gaggttgcag tgagccaaga     1320

ttgcaccact gcactccagc ctgggagata gagtgagact ccatctcaaa aaaataaaaa     1380

ataaaataaa cctacccgga atgaccatgc tgaggactgg gagcccgcag actttcagcc     1440

acaggccgcg acagccgtgg gtccctccct ggtcaagtca gcaggccttg tggaggctgt     1500

ggggtatctg tggtgactca ggtaattata gagggctggc ccccagccct ggttcctgta     1560

cacatgcccc aaccccatcc ccatccactc cctcgccagt cctaacctct ttcctgggtc     1620

cccccccttc agcacctaag tccataccta gggccgtgga attcccgctc aagagcaaca     1680

gaagcccctc tctgcacccc catttctgga ctggattgtc cactgagacg cgcaatgtct     1740

gcatctctga catctagagg cttcctcggg aagggcatgg ggatctccgt gagatgtggg     1800

gactttcact ggccaaccaa gaaatctaca cagcgtccgg ggacctgtga cacacatccc     1860

tcccgcctcc tcaacctgat gtccctctct gaatctgcag ctttcgtgct gtgaaggtgt     1920

ctttacatgt gaaacaaaca aacccaagtc aagagtaaat catctcattt actagtgaga     1980

aaatgttgga gctggagtcc ttcagagagt cctggccagg caagagggcc atcagctctc     2040

ttctgctcaa caggggctct cagcctcagg acactctcag gcctggaatg tccccaacac     2100

actcaaggag aaacatgtcc tgtgcagacc cacaggaggc atctttgccc ggcacaagga     2160

agagctgggg tcagtgggac ctgtagatgt agacacatca tatggagggt gggtaggacc     2220

aatgtggcag cttcatggag gccaagtgtg gctctgcacc aggaaggggc tgtgatggct     2280

ggaggtgccc agcagtgcag gcggggagtg cctggcagtg gcgtggccag gtggaggcca     2340

cctgtcaagt ttgcaataaa gcagtttcct gaatttggtg agaa                      2384


<210>  70
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


<210>  71
<211>  2421
<212>  DNA
<213>  Homo sapiens

<400>  71
gcaatgttta tggtgaaaaa tggcaacggg accgcgtgca taatggccaa cttctctgct       60

gccttctcag tgaactacga caccaagagt ggccctaaga acatgacctt tgacctgcca      120

tcagatgcca cagtggtgct caaccgcagc tcctgtggaa aagagaacac ttctgacccc      180

agtctcgtga ttgcttttgg aagaggacat acactcactc tcaatttcac gagaaatgca      240

acacgttaca gcgtccagct catgagtttt gtttataact tgtcagacac acaccttttc      300

cccaatgcga gctccaaaga aatcaagact gtggaatcta taactgacat cagggcagat      360

atagataaaa aatacagatg tgttagtggc acccaggtcc acatgaacaa cgtgaccgta      420

acgctccatg atgccaccat ccaggcgtac ctttccaaca gcagcttcag ccggggagag      480

acacgctgtg aacaagacag gccttcccca accacagcgc cccctgcgcc acccagcccc      540

tcgccctcac ccgtgcccaa gagcccctct gtggacaagt acaacgtgag cggcaccaac      600

gggacctgcc tgctggccag catggggctg cagctgaacc tcacctatga gaggaaggac      660

aacacgacgg tgacaaggct tctcaacatc aaccccaaca agacctcggc cagcgggagc      720

tgcggcgccc acctggtgac tctggagctg cacagcgagg gcaccaccgt cctgctcttc      780

cagttcggga tgaatgcaag ttctagccgg tttttcctac aaggaatcca gttgaataca      840

attcttcctg acgccagaga ccctgccttt aaagctgcca acggctccct gcgagcgctg      900

caggccacag tcggcaattc ctacaagtgc aacgcggagg agcacgtccg tgtcacgaag      960

gcgttttcag tcaatatatt caaagtgtgg gtccaggctt tcaaggtgga aggtggccag     1020

tttggctctg tggaggagtg tctgctggac gagaacagca tgctgatccc catcgctgtg     1080

ggtggtgccc tggcggggct ggtcctcatc gtcctcatcg cctacctcgt cggcaggaag     1140

aggagtcacg caggctacca gactatctag cctggtgcac gcaggcacag cagctgcagg     1200

ggcctctgtt cctttctctg ggcttagggt cctgtcgaag gggaggcaca ctttctggca     1260

aacgtttctc aaatctgctt catccaatgt gaagttcatc ttgcagcatt tactatgcac     1320

aacagagtaa ctatcgaaat gacggtgtta attttgctaa ctgggttaaa tattttgcta     1380

actggttaaa cattaatatt taccaaagta ggattttgag ggtgggggtg ctctctctga     1440

gggggtgggg gtgccgctgt ctctgagggg tgggggtgcc gctgtctctg aggggtgggg     1500

gtgccgctct ctctgagggg gtgggggtgc cgctttctct gagggggtgg gggtgccgct     1560

ctctctgagg gggtgggggt gctgctctct ccgaggggtg gaatgccgct gtctctgagg     1620

ggtgggggtg ccgctctaaa ttggctccat atcatttgag tttagggttc tggtgtttgg     1680

tttcttcatt ctttactgca ctcagattta agccttacaa agggaaagcc tctggccgtc     1740

acacgtagga cgcatgaagg tcactcgtgg tgaggctgac atgctcacac attacaacag     1800

tagagaggga acatcctaag acagaggaac tccagagatg agtgtctgga gcgcttcagt     1860

tcagctttaa aggccaggac gggccacacg tggctggcgg cctcgttcca gtggcggcac     1920

gtccttgggc gtctctaatg tctgcagctc aagggctggc acttttttaa atataaaaat     1980

gggtgttatt tttattttta tttgtaaagt gatttttggt cttctgttga cattcggggt     2040

gatcctgttc tgcgctgtgt acaatgtgag atcggtgcgt tctcctgatg ttttgccgtg     2100

gcttggggat tgtacacggg accagctcac gtaatgcatt gcctgtaaca atgtaataaa     2160

aagcctcttt ctttttgggg tgggccttgt ccttctgtca gctaaaatgg gagctcatga     2220

gagaaggacg tcagggaaac ggggttgagg gtggtctcgg tgcagagaga agggtgtcag     2280

ggaaacgggg ggtgagggtg gtcttggtgc cagacgtagg gaatggtgtt gggagtggcc     2340

cgagtgcctg gcacagttgt ctggttcatt catgtaacat gataattttt aaatcattaa     2400

aaaaattacc tttcatacag a                                               2421


<210>  72
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe 
        275                 280                 285             


Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  73
<211>  3767
<212>  DNA
<213>  Homo sapiens

<400>  73
aagaaagagc cccgccccta gtcttatgac tcgcactgaa gcgccgattc ctggcttttg       60

caaggctgtg gtcggtggtc atcagtgctc ttgacccagg tccagcgagc cttttccctg      120

gtgttgcagc tgttgttgta ccgccgccgt cgccgccgtc gccgcctgct ctgcggggtc      180

atggtgtgct tccgcctctt cccggttccg ggctcagggc tcgttctggt ctgcctagtc      240

ctgggagctg tgcggtctta tgcattggaa cttaatttga cagattcaga aaatgccact      300

tgcctttatg caaaatggca gatgaatttc acagtacgct atgaaactac aaataaaact      360

tataaaactg taaccatttc agaccatggc actgtgacat ataatggaag catttgtggg      420

gatgatcaga atggtcccaa aatagcagtg cagttcggac ctggcttttc ctggattgcg      480

aattttacca aggcagcatc tacttattca attgacagcg tctcattttc ctacaacact      540

ggtgataaca caacatttcc tgatgctgaa gataaaggaa ttcttactgt tgatgaactt      600

ttggccatca gaattccatt gaatgacctt tttagatgca atagtttatc aactttggaa      660

aagaatgatg ttgtccaaca ctactgggat gttcttgtac aagcttttgt ccaaaatggc      720

acagtgagca caaatgagtt cctgtgtgat aaagacaaaa cttcaacagt ggcacccacc      780

atacacacca ctgtgccatc tcctactaca acacctactc caaaggaaaa accagaagct      840

ggaacctatt cagttaataa tggcaatgat acttgtctgc tggctaccat ggggctgcag      900

ctgaacatca ctcaggataa ggttgcttca gttattaaca tcaaccccaa tacaactcac      960

tccacaggca gctgccgttc tcacactgct ctacttagac tcaatagcag caccattaag     1020

tatctagact ttgtctttgc tgtgaaaaat gaaaaccgat tttatctgaa ggaagtgaac     1080

atcagcatgt atttggttaa tggctccgtt ttcagcattg caaataacaa tctcagctac     1140

tgggatgccc ccctgggaag ttcttatatg tgcaacaaag agcagactgt ttcagtgtct     1200

ggagcatttc agataaatac ctttgatcta agggttcagc ctttcaatgt gacacaagga     1260

aagtattcta cagctgaaga atgttctgct gactctgacc tcaactttct tattcctgtt     1320

gcagtgggtg tggccttggg cttccttata attgttgtct ttatctctta tatgattgga     1380

agaaggaaaa gtcgtactgg ttatcagtct gtgtaatcag ttaaatctag tgtttgtttg     1440

tttttttcaa ttagaagtta cgtttccatt ggctaaaagc caggacatgc tgtgcaatag     1500

attgtttaag atatgcagac taacttcagt gagttcctag ctaacttggg catgagtaca     1560

cttatttaag acaaaatata ttaggaccaa tttttttctg ttttttttct tcctttgtta     1620

aagtataatt aaaagaaaaa ttgtggctta gaatttttta agtaaataat gattttaagc     1680

ccctggatcc aattatgaaa gcatttttgc tgatgtgtaa ttttatatgt tacagttact     1740

tatattttac tactttgatg ttatttgcaa aatcaaaggt gttaaagaat ttaacttgct     1800

tcaggaaata aattcaagaa catagtggat tcattttcat tggtggcaga cacgaaattt     1860

ggttcatgat aagacttcct ttccccacct cctgatcagc attatttaaa tctgtatttt     1920

tctgttagtt aagaaagaaa tggcttcatg atattgtatt taatagcaaa agtttggctg     1980

tcttcttcat tactgttaat agctactata ttttaacaag gagatttctt tttttgttgt     2040

tgttgttcta gagtttggaa tatactgatt atctcagact tgacatttat actgaaggat     2100

gaagtaagac ctccagcttt ttttaaaaaa ggtgttgatt tggaacacct gtatgggtta     2160

tggtttatta aggttatggt ttagaaagtt tttttccctc agagccttaa cttgttaaga     2220

aggttcattt atcctgcact gaaaacaaaa actctatata ctttgtttgt gtgcctcctg     2280

cactctccca ttccctatgt gaatatgctc tagttgatat ttttaatata ttgatttctt     2340

ttttctcaca gcaacaagtg cttactctag aggttagtgg gccctgatat gtcatcagtc     2400

agatgcctgc ctagccaaag ctggactaag attattctgt acatttgttg atcttgatat     2460

agacttatat ccctgtaggg actgctaatg gctccggctt ctggagtaag gtactggaga     2520

ccactcatcc ctgtgtctgc ttgattggtt cagctgttga attgcccttt tatttggaag     2580

cagtgttgaa gttgtctagg gttcaaatgg ctgctttgta cacctgtcat tagtataagg     2640

cagatgttta ttttatcaag ctattttatc tctacattta actaaaaaca aaagttccca     2700

aagatctgcc ttcacttcag aaattttttt tggattaaaa aaattaagcc tgaaccttaa     2760

ataaagtgag ttggttattc attccaagga ttaagtccca atctacctct cagcacaatg     2820

cagaagctca ccactgtatt gctgccatta actcatgcca gaaccctttg ccaataactg     2880

gaattacaaa tttttgttaa agaaaattta tcaagatctt tctttactgc cttctctata     2940

tgtacatctc aaaaacatgt acatctcaaa aactggagta gaaagttaga ttgctcaact     3000

acaactcctc tagaactcta tagctctgac atacagattc acactctcct ctatttgcta     3060

agtatgtaaa gaatgttttc ttttaaaatg ttctcttttg agaacaactg cttatttgtt     3120

ataaaagcat ttggttaaaa tgatgtcatc ataaaaaaca gtggctttgt ttcaatacat     3180

atttttgaga tgattatcta gaagccagat taataaaatc agcttgtgac cttgctaagc     3240

atataaactg gaaattcaga tacattcaaa attatgggtt catttaaaag tgttctacct     3300

tttgggtatg agactaatat cactaattcc tcaatagtta tcatggctct atcttaatta     3360

attagaaaat atgtgtgttt aattctttga gaattaaaat agagaatatt aacagagggt     3420

taaaaactgc ttcaactcca ataagataaa ggaagctcaa aatctatgag ctgagtgttc     3480

aattagcttt gcctactgag ttcaatttta tgtcaataca acagtggatc agacagtacg     3540

actttgaact ggtgaatgta aacaattgtt tttcacctaa gctgctttgg aagaactgat     3600

gcttgctgct aactaaagtt ttggatgtat cgatttagag aaccaattaa tacctgcaaa     3660

ataaagcata ctgtggtact tctgtttgat ctagtatgtg tgattttaga ttgatggatt     3720

aaaaattaat aaagatcata cattccatac caaaaaaaaa aaaaaaa                   3767


<210>  74
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys 
        355                 360                 365             


Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val 
    370                 375                 380                 


Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
                405                 410     


<210>  75
<211>  2389
<212>  DNA
<213>  Homo sapiens

<400>  75
gctgaaactg aagaggacat gtcaaatatt acagatccac agatgtggga ttttgatgat       60

ctaaatttca ctggcatgcc acctgcagat gaagattaca gcccctgtat gctagaaact      120

gagacactca acaagtatgt tgtgatcatc gcctatgccc tagtgttcct gctgagcctg      180

ctgggaaact ccctggtgat gctggtcatc ttatacagca gggtcggccg ctccgtcact      240

gatgtctacc tgctgaacct ggccttggcc gacctactct ttgccctgac cttgcccatc      300

tgggccgcct ccaaggtgaa tggctggatt tttggcacat tcctgtgcaa ggtggtctca      360

ctcctgaagg aagtcaactt ctacagtggc atcctgctgt tggcctgcat cagtgtggac      420

cgttacctgg ccattgtcca tgccacacgc acactgaccc agaagcgtca cttggtcaag      480

tttgtttgtc ttggctgctg gggactgtct atgaatctgt ccctgccctt cttccttttc      540

cgccaggctt accatccaaa caattccagt ccagtttgct atgaggtcct gggaaatgac      600

acagcaaaat ggcggatggt gttgcggatc ctgcctcaca cctttggctt catcgtgccg      660

ctgtttgtca tgctgttctg ctatggattc accctgcgta cactgtttaa ggcccacatg      720

gggcagaagc accgagccat gagggtcatc tttgctgtcg tcctcatctt cctgctttgc      780

tggctgccct acaacctggt cctgctggca gacaccctca tgaggaccca ggtgatccag      840

gagagctgtg agcgccgcaa caacatcggc cgggccctgg atgccactga gattctggga      900

tttctccata gctgcctcaa ccccatcatc tacgccttca tcggccaaaa ttttcgccat      960

ggattcctca agatcctggc tatgcatggc ctggtcagca aggagttctt ggcacgtcat     1020

cgtgttacct cctacacttc ttcgtctgtc aatgtctctt ccaacctctg aaaaccatcg     1080

atgaaggaat atctcttctc agaaggaaag aataaccaac accctgaggt tgtgtgtgga     1140

aggtgatctg gctctggaca ggcactatct gggttttggg gggacgctat aggatgtggg     1200

gaagttagga actggtgtct tcaggggcca caccaacctt ctgaggagct gttgaggtac     1260

ctccaaggac cggcctttgc acctccatgg aaacgaagca ccatcattcc cgttgaacgt     1320

cacatcttta acccactaac tggctaatta gcatggccac atctgagccc cgaatctgac     1380

attagatgag agaacagggc tgaagctgtg tcctcatgag ggctggatgc tctcgttgac     1440

cctcacagga gcatctcctc aactctgagt gttaagcgtt gagccaccaa gctggtggct     1500

ctgtgtgctc tgatccgagc tcaggggggt ggttttccca tctcaggtgt gttgcagtgt     1560

ctgctggaga cattgaggca ggcactgcca aaacatcaac ctgccagctg gccttgtgag     1620

gagctggaaa cacatgttcc ccttgggggt ggtggatgaa caaagagaaa gagggtttgg     1680

aagccagatc tatgccacaa gaaccccctt tacccccatg accaacatcg cagacacatg     1740

tgctggccac ctgctgagcc ccaagtggaa cgagacaagc agcccttagc ccttcccctc     1800

tgcagcttcc aggctggcgt gcagcatcag catccctaga aagccatgtg cagccaccag     1860

tccattgggc aggcagatgt tcctaataaa gcttctgttc cgtgcttgtc cctgtggaag     1920

tatcttggtt gtgacagagt caagggtgtg tgcagcattg ttggctgttc ctgcagtaga     1980

atgggggcag cacctcctaa gaaggcacct ctctgggttg aagggcagtg ttccctgggg     2040

ctttaactcc tgctagaaca gtctcttgag gcacagaaac tcctgttcat gcccataccc     2100

ctggccaagg aagatccctt tgtccacaag taaaaggaaa tgctcctcca gggagtctca     2160

gcttcaccct gaggtgagca tcatcttctg ggttaggcct tgcctaggca tagccctgcc     2220

tcaagctatg tgagctcacc agtccctccc caaatgcttt ccatgagttg cagttttttc     2280

ctagtctgtt ttccctcctt ggagacaggg ccctgtcggt ttattcactg tatgtccttg     2340

gtgcctggag cctactaaat gctcaataaa taatgatcac aggaatgaa                 2389


<210>  76
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  77
<211>  2446
<212>  DNA
<213>  Homo sapiens

<400>  77
ctccgatcca gaacactacc gcgcagcaaa atcatctgcc ttgttgtgtg ggggctgtca       60

gtcatcatct ccagctcaac ttttgtcttc aaccaaaaat acaacaccca aggcagcgat      120

gtctgtgaac ccaagtacca gactgtctcg gagcccatca ggtggaagct gctgatgttg      180

gggcttgagc tactctttgg tttctttatc cctttgatgt tcatgatatt ttgttacacg      240

ttcattgtca aaaccttggt gcaagctcag aattctaaaa ggcacaaagc catccgtgta      300

atcatagctg tggtgcttgt gtttctggct tgtcagattc ctcataacat ggtcctgctt      360

gtgacggctg caaatttggg taaaatgaac cgatcctgcc agagcgaaaa gctaattggc      420

tatacgaaaa ctgtcacaga agtcctggct ttcctgcact gctgcctgaa ccctgtgctc      480

tacgctttta ttgggcagaa gttcagaaac tactttctga agatcttgaa ggacctgtgg      540

tgtgtgagaa ggaagtacaa gtcctcaggc ttctcctgtg ccgggaggta ctcagaaaac      600

atttctcggc agaccagtga gaccgcagat aacgacaatg cgtcgtcctt cactatgtga      660

tagaaagctg agtctcccta aggcatgtgt gaaacatact catagatgtt atgcaaaaaa      720

aagtctatgg ccaggtatgc atggaaaatg tgggaattaa gcaaaatcaa gcaagcctct      780

ctcctgcggg acttaacgtg ctcatgggct gtgtgatctc ttcagggtgg ggtggtctct      840

gataggtagc attttccagc actttgcaag gaatgttttg tagctctagg gtatatatcc      900

gcctggcatt tcacaaaaca gcctttggga aatgctgaat taaagtgaat tgttgacaaa      960

tgtaaacatt ttcagaaata ttcatgaagc ggtcacagat cacagtgtct tttggttaca     1020

gcacaaaatg atggcagtgg tttgaaaaac taaaacagaa aaaaaaatgg aagccaacac     1080

atcactcatt ttaggcaaat gtttaaacat ttttatctat cagaatgttt attgttgctg     1140

gttataagca gcaggattgg ccggctagtg tttcctctca tttccctttg atacagtcaa     1200

caagcctgac cctgtaaaat ggaggtggaa agacaagctc aagtgttcac aacctggaag     1260

tgcttcggga agaaggggac aatggcagaa caggtgttgg tgacaattgt caccaattgg     1320

ataaagcagc tcaggttgta gtgggccatt aggaaactgt cggtttgctt tgatttccct     1380

gggagctgtt ctctgtcgtg agtgtctctt gtctaaacgt ccattaagct gagagtgcta     1440

tgaagacagg atctagaata atcttgctca cagctgtgct ctgagtgcct agcggagttc     1500

cagcaaacaa aatggactca agagagattt gattaatgaa tcgtaatgaa gttggggttt     1560

attgtacagt ttaaaatgtt agatgttttt aattttttaa ataaatggaa tacttttttt     1620

ttttttttaa agaaagcaac tttactgaga caatgtagaa agaagttttg ttccgtttct     1680

ttaatgtggt tgaagagcaa tgtgtggctg aagacttttg ttatgaggag ctgcagatta     1740

gctaggggac agctggaatt atgctggctt ctgataatta ttttaaaggg gtctgaaatt     1800

tgtgatggaa tcagatttta acagctctct tcaatgacat agaaagttca tggaactcat     1860

gtttttaaag ggctatgtaa atatatgaac attagaaaaa tagcaacttg tgttacaaaa     1920

atacaaacac atgttaggaa ggtactgtca tgggctaggc atggtggctc acacctgtaa     1980

tcccagcatt ttgggaagct aagatgggtg gatcacttga ggtcaggagt ttgagaccag     2040

cctggccaac atggcgaaac ccctctctac taaaaataca aaaatttgcc aggcgtggtg     2100

gcgggtgcct gtaatcccag ctacttggga ggctgaggca agagaatcgc ttgaacccag     2160

gaggcagagg ttgcagtgag ccgagatcgt gccattgcac tccagcctgg gtgacaaagc     2220

gagactccat ctcaaaaaaa aaaaaaaaaa aaaaggaaag aactgtcatg taaacatacc     2280

aacatgttta aacctgacaa tggtgttatt tgaaacttta tattgttctt gtaagcttta     2340

actatatctc tctttaaaat gcaaaataat gtcttaagat tcaaagtctg tatttttaaa     2400

gcatggcttt ggctttgcaa aataaaaaat gtgttttgta catgaa                    2446


<210>  78
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  79
<211>  2588
<212>  DNA
<213>  Homo sapiens

<400>  79
aggctaaggt cagacactga cacttgcagt tgtctttggt agtttttttg cactaacttc       60

aggaaccagc tcatgatctc aggatgtatg gaaaaataat ctttgtatta ctattgtcag      120

aaattgtgag catatcagca ttaagtacca ctgaggtggc aatgcacact tcaacttctt      180

cttcagtcac aaagagttac atctcatcac agacaaatga tacgcacaaa cgggacacat      240

atgcagccac tcctagagct catgaagttt cagaaatttc tgttagaact gtttaccctc      300

cagaagagga aaccgagata acactcatta tttttggggt gatggctggt gttattggaa      360

cgatcctctt aatttcttac ggtattcgcc gactgataaa gaaaagccca tctgatgtaa      420

aacctctccc ctcacctgac acagacgtgc ctttaagttc tgttgaaata gaaaatccag      480

agacaagtga tcaatgagaa tctgttcacc aaaccaaatg tggaaagaac acaaagaaga      540

cataagactt cagtcaagtg aaaaattaac atgtggactg gacactccaa taaattatat      600

acctgcctaa gttgtacaat ttcagaatgc aattttcatt ataatgagtt ccagtgactc      660

aatgatgggg aaaaaaatct ctgctcatta atatttcaag ataaagaaca aatgtttcct      720

tgaatgcttg cttttgtgtg ttagcataat ttttagaatt gtttgagaat tctgatccaa      780

aactttagtt gaattcatct acgtttgttt aatattaact taacctattc tattgtatta      840

taatgatgat tctgtcaaat gaaaggcttg aaatacctag atgaagttta gattttcttc      900

ctattgtaaa cttttgagtc tggtttcatt gttttaaata aattaagggg acactaaagt      960

cctatcattc atttccttca ttgctgaaca ggcaagatat aatattacat gaatgattac     1020

tatattttgt tcacactaat aaagcttatg ctcagaaatg ccatacacac acacacacac     1080

acacacaaac acacacattt atcatttaat gcataaatca acacaaaagg ttttcccatt     1140

aatatgaaat attacatata tataagtgcc atatttaaaa taatttgtct aacagtagaa     1200

ctgtgtcgga gcactcactg aagcttgcat tccactgaaa gagttatttg tgtaagtaga     1260

gtatccggag aaggaaaaga acttacgacc tttctttata acagaaactc aactctaaat     1320

tcaacaagat gtgcaaaccg gacatgcagg tgaatatttt aataggttac tataaggttc     1380

tcaattaaat tctttaatct gtccagtccc agtttctctt attaataaaa ctttggaaat     1440

tgctttaaac catttaaagg aaatttctag atatagaaac taaggactgt gactatacag     1500

ctgtcactca tttgtagtaa aacttaaaaa gcaaaaacaa aaaacaaaaa agaccttcct     1560

gtgatacttt atttccgaac taataaaaat ctatatgact ttttattatt gtgtgataac     1620

caagtaaatg ttttctattt tgcatatttt caggcatggt aacagaaatt taccttttaa     1680

taaattaaaa aatctaaatt ttaacctact tgtatgttcg gagagtgttt ttgtactata     1740

ttgactactt aaaatagaga atgagactaa gaagggaaca tttctgttga tacatgtttt     1800

ttaaaagtaa ttttaagagc attattaggt taattaatcc aattaatgac ccaaatgcca     1860

aggtaatttt aaatttacat ttttaataaa agcaacatgt tgaaacaaga gagggtgaga     1920

ttaacctttt tgctaaagta atttacaagt caaagacagg aagagatcag agtgaatgtg     1980

ccttcttaac cagagctaca gaatttagtg aataattaaa gtacaaactg ctttgacctc     2040

cttgaacttt tccaagcaat ttctctgtac ttctatatat gaatgtctta gccaattttc     2100

tgctactata acagaatacg acagactggg taatttaaaa agaaaagaaa tttattttct     2160

tcctagttct ggaggctggg aaggcgaagg gcatggcact gacatctgcc ttgtaactga     2220

tgagaacctt cttactgcat gataacaaag cagcaaggca agcaaaagcg taagatgaag     2280

agagaggaaa tgaagccaaa cacatccttt catcagaagc ccattccctc tataaggcgt     2340

tattacattt atgagaatgg agtcctcatg acctaatcgt gaccttaaag gcccctccca     2400

acactgttac aatggcaatt aaatttcaac aaaggttcca gaggtgacat tcgaatcagc     2460

aatgaaattt tcatagttaa atttggtatt cgtgggggaa gaaatgacca tttcccttgt     2520

atttttataa ttaaatcagc aaaatattgt aataaagaaa tctttcctgt gaagatacca     2580

tgacccca                                                              2588


<210>  80
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Glu Ile Thr 
65                  70                  75                  80  


Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu 
                85                  90                  95      


Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val 
            100                 105                 110         


Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu 
        115                 120                 125             


Ile Glu Asn Pro Glu Thr Ser Asp Gln 
    130                 135         


<210>  81
<211>  1611
<212>  DNA
<213>  Homo sapiens

<400>  81
gagaagccaa tcagtgtcgt cgcggtcgct gttctaaagt ccgcacgcac ccaccgggac       60

tcagattctc cccagacgcc gaggatggcc gtcatggcgc cccgaaccct cctcctgcta      120

ctctcggggg ccctggccct gacccagacc tgggcgggct cccactccat gaggtatttc      180

ttcacatccg tgtcccggcc cggccgcggg gagccccgct tcatcgccgt gggctacgtg      240

gacgacacgc agttcgtgcg gttcgacagc gacgccgcga gccagaagat ggagccgcgg      300

gcgccgtgga tagagcagga ggggccggag tattgggacc aggagacacg gaatatgaag      360

gcccactcac agactgaccg agcgaacctg gggaccctgc gcggctacta caaccagagc      420

gaggacggtt ctcacaccat ccagataatg tatggctgcg acgtggggcc ggacgggcgc      480

ttcctccgcg ggtaccggca ggacgcctac gacggcaagg attacatcgc cctgaacgag      540

gacctgcgct cttggaccgc ggcggacatg gcagctcaga tcaccaagcg caagtgggag      600

gcggtccatg cggcggagca gcggagagtc tacctggagg gccggtgcgt ggacgggctc      660

cgcagatacc tggagaacgg gaaggagacg ctgcagcgca cggacccccc caagacacat      720

atgacccacc accccatctc tgaccatgag gccaccctga ggtgctgggc cctgggcttc      780

taccctgcgg agatcacact gacctggcag cgggatgggg aggaccagac ccaggacacg      840

gagctcgtgg agaccaggcc tgcaggggat ggaaccttcc agaagtgggc ggctgtggtg      900

gtgccttctg gagaggagca gagatacacc tgccatgtgc agcatgaggg tctgcccaag      960

cccctcaccc tgagatggga gctgtcttcc cagcccacca tccccatcgt gggcatcatt     1020

gctggcctgg ttctccttgg agctgtgatc actggagctg tggtcgctgc cgtgatgtgg     1080

aggaggaaga gctcagatag aaaaggaggg agttacactc aggctgcaag cagtgacagt     1140

gcccagggct ctgatgtgtc tctcacagct tgtaaagtgt gagacagctg ccttgtgtgg     1200

gactgagagg caagagttgt tcctgccctt ccctttgtga cttgaagaac cctgactttg     1260

tttctgcaaa ggcacctgca tgtgtctgtg ttcgtgtagg cataatgtga ggaggtgggg     1320

agagcacccc acccccatgt ccaccatgac cctcttccca cgctgacctg tgctccctct     1380

ccaatcatct ttcctgttcc agagaggtgg ggctgaggtg tctccatctc tgtctcaact     1440

tcatggtgca ctgagctgta acttcttcct tccctattaa aattagaacc tgagtataaa     1500

tttactttct caaattcttg ccatgagagg ttgatgagtt aattaaagga gaagattcct     1560

aaaatttgag agacaaaatt aatggaacgc atgagaacct tccagagtcc a              1611


<210>  82
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


