                         SEQUENCE LISTING

<110>  VANDERBILT UNIVERSITY
 
<120>  HUMAN MONOCLONAL ANTIBODIES TO SEVERE ACUTE RESPIRATORY SYNDROME 
       CORONAVIRUS 2 (SARS-CoV-2)

<130>  VBLT.P0307WO4A

<150>  US 63/000,299
<151>  2020-03-26

<150>  US 63/003,716
<151>  2020-04-01

<150>  US 63/024,204
<151>  2020-05-13

<150>  US 63/040,224
<151>  2020-06-17

<150>  US 63/000,735
<151>  2020-03-27

<150>  US 63/024,214
<151>  2020-05-13

<150>  US 63/002,896
<151>  2020-03-31

<150>  US 63/024,248
<151>  2020-05-13

<150>  US 63/027,173
<151>  2020-05-19

<150>  US 63/037,984
<151>  2020-06-11

<150>  US 63/040,246
<151>  2020-06-17

<150>  US 63/142,196
<151>  2021-01-27

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  1
caaatgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggacctc agtaaaagtc       60

tcctgcaaga cttctggatt cacctttact agctctgcta tacagtgggt gcgacaggct      120

cgtggacaac gccttgagtg gattggatgg atcgtcgttg gcagtggtaa cacaaactac      180

gcacagaagt tccaggaaag agtcaccatt accagggaca tgtccacaag cacagcctac      240

atggagctga gcagcctgag atccgaggac acggccgtgt attactgtgc ggctccccat      300

tgtaatagga ccagctgcta tgatgctttt gatctctggg gccaagggac aatggtcacc      360

gtctcttcag                                                             370


<210>  2
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  2
gaaattgtgt tgacacagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact taggctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  3
<211>  370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  3
caaatgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggacctc agtgaaggtc       60

tcctgcaagg cttctggatt cacctttact agctctgctg tgcagtgggt gcgacaggct      120

cgtggacaac gccttgagtg gataggatgg atcgccgttg gcagtggtaa cacaaactac      180

gcacagaagt tccaggaaag agtcagcatt accagggaca tgtccacaag cacagcctac      240

atggagctga gcagcctgag atccgaggac acggccgtgt attattgtgc ggccccttat      300

tgtagtagaa ccagctgcca tgatgctttt gatatctggg gccaagggac aaaggtcacc      360

gtctcttcag                                                             370


<210>  4
<211>  328
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  4
gaagttgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta tcactgtcag cactttggta gctcatctca gtggacgttc      300

ggccaaggga ccaaggtgga aatcaaac                                         328


<210>  5
<211>  387
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  5
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgtt acctctggca tacactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaaggaggg      300

ccaaacaagg aagtactata tttcggggag ttattggact acggtatgga cgtctggggc      360

caagggacca cggtcaccgt ctcctca                                          387


<210>  6
<211>  337
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  6
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

ttctcctgca agtctagtca gagcctcctg catagtgatg gaaagaccta tttgtactgg      120

tacctgcaga agccaggcca gtctccacaa ctcctgatct atgcagtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat acagcttccg      300

tacacttttg gccaggggac caagctggag atcaaac                               337


<210>  7
<211>  369
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  7
caaatgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggacctc agtaaaagtc       60

tcctgcaaga cttctggatt cacctttact agctctgcta tacagtgggt gcgacaggct      120

cgtggacaac gccttgagtg gattggatgg atcgtcgttg gcagtggtaa cacaaactac      180

gcacagaagt tccaggaaag agtcaccatt accagggaca tgtccacaag cacagcctac      240

atggagctga gcagcctgag atccgaggac acggccgtgt attactgtgc ggctccccat      300

tgtaatagga ccagctgcta tgatgctttt gatctctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210>  8
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  8
gaaattgtgt tgacacagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact taggctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210>  9
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  9

Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Ala Ile Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  11

Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ala Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Ser Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Tyr Cys Ser Arg Thr Ser Cys His Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Lys Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  12

Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr His Cys Gln His Phe Gly Ser Ser Ser 
                85                  90                  95      


Gln Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  13
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Thr Ser 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Pro Asn Lys Glu Val Leu Tyr Phe Gly Glu Leu Leu 
            100                 105                 110         


Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  14
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  14

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Phe Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Ala Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Ile Gln Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  15

Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          


Ala Ile Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  17

Gly Phe Thr Phe Thr Ser Ser Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  18

Ile Val Val Gly Ser Gly Asn Thr 
1               5               


<210>  19
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  19

Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu 
1               5                   10                  15      


<210>  20
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  20

Gly Phe Thr Phe Thr Ser Ser Ala 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  21

Ile Ala Val Gly Ser Gly Asn Thr 
1               5               


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  22

Ala Ala Pro Tyr Cys Ser Arg Thr Ser Cys His Asp Ala Phe Asp Ile 
1               5                   10                  15      


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  23

Gly Phe Thr Phe Val Thr Ser Gly 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  24

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  25
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  25

Ala Lys Gly Gly Pro Asn Lys Glu Val Leu Tyr Phe Gly Glu Leu Leu 
1               5                   10                  15      


Asp Tyr Gly Met Asp Val 
            20          


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  26

Gly Phe Thr Phe Thr Ser Ser Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  27

Ile Val Val Gly Ser Gly Asn Thr 
1               5               


<210>  28
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  28

Ala Ala Pro His Cys Asn Arg Thr Ser Cys Tyr Asp Ala Phe Asp Leu 
1               5                   10                  15      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  29

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  30

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  31
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  31

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  32
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  32

Gln His Phe Gly Ser Ser Ser Gln Trp Thr 
1               5                   10  


<210>  33
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  33

Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  34
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  34

Met Gln Ser Ile Gln Leu Pro Tyr Thr 
1               5                   


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  35

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic antibody

<400>  36

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  37
atgctgcaat cgtgctacaa                                                   20


<210>  38
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  38
gactgccgcc tctgctc                                                      17


