                         SEQUENCE LISTING

<110>  Seagen Inc.
 
<120>  METHODS OF TREATING MULTIPLE MYELOMA

<130>  49223-0034WO1

<150>  63/000,229
<151>  2020-03-26

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  1

Asp Tyr Tyr Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  2

Tyr Ile Asn Pro Asn Ser Gly Tyr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  3

Tyr Met Trp Glu Arg Val Thr Gly Phe Phe Asp Phe 
1               5                   10          


<210>  4
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy Chain Variable Domain

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Gly Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Tyr Met Trp Glu Arg Val Thr Gly Phe Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  5

Leu Ala Ser Glu Asp Ile Ser Asp Asp Leu Ala 
1               5                   10      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  6

Thr Thr Ser Ser Leu Gln Ser 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  7

Gln Gln Thr Tyr Lys Phe Pro Pro Thr 
1               5                   


<210>  8
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Light Chain Variable Domain

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ser Asp Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Val 
        35                  40                  45              


Tyr Thr Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Lys Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  10
<211>  994
<212>  DNA
<213>  Homo sapiens

<400>  10
aagactcaaa cttagaaact tgaattagat gtggtattca aatccttagc tgccgcgaag       60

acacagacag cccccgtaag aacccacgaa gcaggcgaag ttcattgttc tcaacattct      120

agctgctctt gctgcatttg ctctggaatt cttgtagaga tattacttgt ccttccaggc      180

tgttctttct gtagctccct tgttttcttt ttgtgatcat gttgcagatg gctgggcagt      240

gctcccaaaa tgaatatttt gacagtttgt tgcatgcttg cataccttgt caacttcgat      300

gttcttctaa tactcctcct ctaacatgtc agcgttattg taatgcaagt gtgaccaatt      360

cagtgaaagg aacgaatgcg attctctgga cctgtttggg actgagctta ataatttctt      420

tggcagtttt cgtgctaatg tttttgctaa ggaagataaa ctctgaacca ttaaaggacg      480

agtttaaaaa cacaggatca ggtctcctgg gcatggctaa cattgacctg gaaaagagca      540

ggactggtga tgaaattatt cttccgagag gcctcgagta cacggtggaa gaatgcacct      600

gtgaagactg catcaagagc aaaccgaagg tcgactctga ccattgcttt ccactcccag      660

ctatggagga aggcgcaacc attcttgtca ccacgaaaac gaatgactat tgcaagagcc      720

tgccagctgc tttgagtgct acggagatag agaaatcaat ttctgctagg taattaacca      780

tttcgactcg agcagtgcca ctttaaaaat cttttgtcag aatagatgat gtgtcagatc      840

tctttaggat gactgtattt ttcagttgcc gatacagctt tttgtcctct aactgtggaa      900

actctttatg ttagatatat ttctctaggt tactgttggg agcttaatgg tagaaacttc      960

cttggtttca tgattaaact cttttttttc ctga                                  994


<210>  11
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy Chain Variable Domain

<400>  11
caagtgcagc tggtgcagtc cggagcggaa gtgaagaaac ctggggcgtc cgtgaagctc       60

agctgcaagg cctccggcta cactttcacc gattactaca tccactgggt cagacaggca      120

ccgggacagg gactggagtg gattggttac atcaacccca actccgggta caccaattac      180

gcccagaagt tccagggtcg ggctacgatg accgccgaca agtcgatcaa cactgcctac      240

gtggaactgt caaggctgcg gtccgatgac accgccgtgt acttctgtac ccgctatatg      300

tgggagcgcg tgactggatt tttcgacttc tggggccaag gcaccatggt caccgtgtcg      360

agc                                                                    363


<210>  12
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Light Chain Variable Domain

<400>  12
gacattcaga tgacccagtc cccctcgtcc gtgtccgctt ccgtgggaga tcgcgtgacc       60

atcacttgtc ttgcgtccga ggatatctca gacgacctgg cctggtacca gcagaagcct      120

ggaaaggccc cgaaggtcct ggtgtacact accagcagcc tccagtcggg cgtgccttca      180

cggttctccg gttcggggtc tggcaccgac ttcaccctga ctattagctc cctgcaaccc      240

gaggacttcg ccacctactt ttgccagcaa acctacaagt tcccgccaac gttcggaggg      300

ggcaccaagg tcgaaatcaa acgt                                             324


<210>  13
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy Chain

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Ser Gly Tyr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Tyr Met Trp Glu Arg Val Thr Gly Phe Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  14
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy Chain

<400>  14
caagtgcagc tggtgcagtc cggagcggaa gtgaagaaac ctggggcgtc cgtgaagctc       60

agctgcaagg cctccggcta cactttcacc gattactaca tccactgggt cagacaggca      120

ccgggacagg gactggagtg gattggttac atcaacccca actccgggta caccaattac      180

gcccagaagt tccagggtcg ggctacgatg accgccgaca agtcgatcaa cactgcctac      240

gtggaactgt caaggctgcg gtccgatgac accgccgtgt acttctgtac ccgctatatg      300

tgggagcgcg tgactggatt tttcgacttc tggggccaag gcaccatggt caccgtgtcg      360

agcgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggccgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaggttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggac     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  15
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Light Chain

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ser Asp Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Val 
        35                  40                  45              


Tyr Thr Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Lys Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  16
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  Light Chain

<400>  16
gacattcaga tgacccagtc cccctcgtcc gtgtccgctt ccgtgggaga tcgcgtgacc       60

atcacttgtc ttgcgtccga ggatatctca gacgacctgg cctggtacca gcagaagcct      120

ggaaaggccc cgaaggtcct ggtgtacact accagcagcc tccagtcggg cgtgccttca      180

cggttctccg gttcggggtc tggcaccgac ttcaccctga ctattagctc cctgcaaccc      240

gaggacttcg ccacctactt ttgccagcaa acctacaagt tcccgccaac gttcggaggg      300

ggcaccaagg tcgaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


