                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS COMPRISING A 
       V30M MUTATION AND METHODS OF USE

<130>  057766/556520

<150>  US 62/993,289
<151>  2020-03-23

<160>  155   

<170>  PatentIn version 3.5

<210>  1
<211>  147
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Signal Peptide

<400>  1

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Signal Peptide

<400>  2

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Met His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala 
            20  


<210>  4
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  5
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Met His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  6
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Signal Peptide

<400>  6
atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct       60

ggccctacgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc      120

cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc      180

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      240

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      300

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      360

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      420

gtcgtcacca atcccaagga atga                                             444


<210>  7
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Signal Peptide

<400>  7
atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct       60

ggccctacgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc      120

cgaggcagtc ctgccatcaa tgtggccatg catgtgttca gaaaggctgc tgatgacacc      180

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      240

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      300

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      360

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      420

gtcgtcacca atcccaagga atga                                             444


<210>  8
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct       60


<210>  9
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ggccctacgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc       60

cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc      120

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      180

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      240

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      300

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      360

gtcgtcacca atcccaagga atga                                             384


<210>  10
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ggccctacgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc       60

cgaggcagtc ctgccatcaa tgtggccatg catgtgttca gaaaggctgc tgatgacacc      120

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      180

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      240

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      300

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      360

gtcgtcacca atcccaagga atga                                             384


<210>  11
<211>  938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc tgatggtcaa      240

agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg tgttcagaaa      300

ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt ctggagagct      360

gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg aaatagacac      420

caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag aggtggtatt      480

cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc      540

ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga      600

cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt actaaagcag      660

tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga      720

aaggcacttt tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa      780

aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa      840

cgctaggaga gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct      900

gcagccatta aaaagacaca ttctgtaaaa aaaaaaaa                              938


<210>  12
<211>  7258
<212>  DNA
<213>  Homo sapiens

<400>  12
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacggtgag tgtttctgtg acatcccatt cctacattta      240

agattcacgc taaatgaagt agaagtgact ccttccagct ttgccaacca gcttttatta      300

ctagggcaag ggtacccagc atctattttt aatataatta attcaaactt caaaaagaat      360

gaagttccac tgagcttact gagctgggac ttgaactctg agcattctac ctcattgctt      420

tggtgcatta ggtttgtaat atctggtacc tctgtttcct cagatagatg atagaaataa      480

agatatgata ttaaggaagc tgttaatact gaattttcag aaaagtatcc ctccataaaa      540

tgtatttggg ggacaaactg caggagatta tattctggcc ctatagttat tcaaaacgta      600

tttattgatt aatctttaaa aggcttagtg aacaatattc tagtcagata tctaattctt      660

aaatcctcta gaagaattaa ctaatactat aaaatgggtc tggatgtagt tctgacatta      720

ttttataaca actggtaaga gggagtgact atagcaacaa ctaaaatgat ctcaggaaaa      780

cctgtttggc cctatgtatg gtacattaca tcttttcagt aattccactc aaatggagac      840

ttttaacaaa gcaactgttc tcaggggacc tattttctcc cttaaaattc attatacaca      900

tccctggttg atagcagtgt gtctggaggc agaaaccatt cttgctttgg aaacaattac      960

gtctgtgtta tactgagtag ggaagctcat taattgtcga cacttacgtt cctgataatg     1020

ggatcagtgt gtaattcttg tttcgctcca gatttctaat accacaaaga ataaatcctt     1080

tcactctgat caattttgtt aacttctcac gtgtcttctc tacacccagg gcaccggtga     1140

atccaagtgt cctctgatgg tcaaagttct agatgctgtc cgaggcagtc ctgccatcaa     1200

tgtggccgtg catgtgttca gaaaggctgc tgatgacacc tgggagccat ttgcctctgg     1260

gtaagttgcc aaagaaccct cccacaggac ttggttttat cttcccgttt gcccctcact     1320

tggtagagag aggctcacat catctgctaa agaatttaca agtagattga aaaacgtagg     1380

cagaggtcaa gtatgccctc tgaaggatgc cctctttttg ttttgcttag ctaggaagtg     1440

accaggaacc tgagcatcat ttaggggcag acagtagaga aaagaaggaa tcagaactcc     1500

tctcctctag ctgtggtttg caaccctttt gggtcacaga acactttatg taggtgatga     1560

aaagtaaaca ttctatgccc agaaaaaatg cacagataca cacacataca aaatcatata     1620

tgtgatttta ggagtttcac agattccctg gtgtccctgg gtaacaccaa agctaagtgt     1680

ccttgtctta gaattttagg aaaaggtata atgtgtatta acccattaac aaaaggaaag     1740

gaattcagaa atattattaa ccaggcatct gtctgtagtt aatatggatc acccaaaacc     1800

caaggctttt gcctaatgaa cactttgggg cacctactgt gtgcaaggct gggggctgtc     1860

aagctcagtt aaaaaaaaaa agatagaaga gatggatcca tgaggcaaag tacagcccca     1920

ggctaatccc acgatcaccc gacttcatgt ccaagagtgg cttctcacct tcattagcca     1980

gttcacaatt ttcatggagt ttttctacct gcactagcaa aaacttcaag gaaaatacat     2040

attaataaat ctaagcaaag tgaccagaag acagagcaat caggagaccc tttgcatcca     2100

gcagaagagg aactgctaag tatttacatc tccacagaga agaatttctg ttgggtttta     2160

attgaacccc aagaaccaca tgattcttca accattattg ggaagatcat tttcttaggt     2220

ctggttttaa ctggcttttt atttgggaat tcatttatgt ttatataaaa tgccaagcat     2280

aacatgaaaa gtggttacag gactattcta agggagagac agaatggaca ccaaaaatat     2340

tccaatgttc ttgtgaatct tttccttgca ccaggacaaa aaaaaaaaga agtgaaaaga     2400

agaaaggagg aggggcataa tcagagtcag taaagacaac tgctattttt atctatcgta     2460

gctgttgcag tcaaatggga agcaatttcc aacattcaac tatggagctg gtacttacat     2520

ggaaatagaa gttgcctagt gtttgttgct ggcaaagagt tatcagagag gttaaatata     2580

taaaagggaa aagagtcaga tacaggttct tcttcctact ttaggttttc cactgtgtgt     2640

gcaaatgata ctccctggtg gtgtgcagat gcctcaaagc tatcctcaca ccacaaggga     2700

gaggagcgag atcctgctgt cctggagaag tgcagagtta gaacagctgt ggccacttgc     2760

atccaatcat caatcttgaa tcacagggac tctttcttaa gtaaacatta tacctggccg     2820

ggcacggtgg ctcacgcctg taatcccagc actttgggat gccaaagtgg gcatatcatc     2880

tgaggtcagg agttcaagac cagcctggcc aacatggcaa aactccgtct ttatgaaaaa     2940

tacaaaaatt agccaggcat ggtggcaggc gcctgtaatc ccagctaatt gggaggctga     3000

ggctggagaa tcccttgaat ctaggaggca gaggttgcag tgagctgaga tcgtgccatt     3060

gcactccagc ctgggtgaca agagtaaaac tctgtctcaa aaaaaaaaaa ttatacctac     3120

attctcttct tatcagagaa aaaaatctac agtgagcttt tcaaaaagtt tttacaaact     3180

ttttgccatt taatttcagt taggagtttt ccctacttct gacttagttg aggggaaatg     3240

ttcataacat gtttataaca tgtttatgtg tgttagttgg tgggggtgta ttactttgcc     3300

atgccatttg tttcctccat gcgtaactta atccagactt tcacacctta taggaaaacc     3360

agtgagtctg gagagctgca tgggctcaca actgaggagg aatttgtaga agggatatac     3420

aaagtggaaa tagacaccaa atcttactgg aaggcacttg gcatctcccc attccatgag     3480

catgcagagg tgagtataca gaccttcgag ggttgttttg gttttggttt ttgcttttgg     3540

cattccagga aatgcacagt tttactcagt gtaccacaga aatgtcctaa ggaaggtgat     3600

gaatgaccaa aggttccctt tcctattata caagaaaaaa ttcacaacac tctgagaagc     3660

aaatttcttt ttgactttga tgaaaatcca cttagtaaca tgacttgaac ttacatgaaa     3720

ctactcatag tctattcatt ccactttata tgaatattga tgtatctgct gttgaaataa     3780

tagtttatga ggcagccctc cagaccccac gtagagtgta tgtaacaaga gatgcaccat     3840

tttatttctc gaaaacccgt aacattcttc attccaaaac acatctggct tctcggaggt     3900

ctggacaagt gattcttggc aacacatacc tatagagaca ataaaatcaa agtaataatg     3960

gcaacacaat agataacatt taccaagcat acaccatgtg gcagacacaa ttataagtgt     4020

tttccatatt taacctactt aatcctcagg aataagccac tgaggtcagt cctattatta     4080

tccccatctt atagatgaag aaaatgaggc accaggaagt caaataactt gtcaaaggtc     4140

acaagactag gaaatacaca agtagaaatg tttacaatta aggcccaggc tgggtttgcc     4200

ctcagttctg ctatgcctcg cattatgccc caggaaactt tttcccttgt gaaagccaag     4260

cttaaaaaaa gaaaagccac atttgtaacg tgctctgttc ccctgcctat ggtgaggatc     4320

ttcaaacagt tatacatgga cccagtcccc ctgccttctc cttaatttct taagtcattt     4380

gaaacagatg gctgtcatgg aaatagaatc cagacatgtt ggtcagagtt aaagatcaac     4440

taattccatc aaaaatagct cggcatgaaa gggaactatt ctctggctta gtcatggatg     4500

agactttcaa ttgctataaa gtggttcctt tattagacaa tgttaccagg gaaacaacag     4560

gggtttgttt gacttctggg gcccacaagt caacaagaga gccccatcta ccaaggagca     4620

tgtccctgac tacccctcag ccagcagcaa gacatggacc ccagtcaggg caggagcagg     4680

gtttcggcgg cgcccagcac aagacattgc ccctagagtc tcagccccta ccctcgagta     4740

atagatctgc ctacctgaga ctgttgtttg cccaagagct gggtctcagc ctgatgggaa     4800

ccatataaaa aggttcactg acatactgcc cacatgttgt tctctttcat tagatcttag     4860

cttccttgtc tgctcttcat tcttgcagta ttcattcaac aaacattaaa aaaaaaaaaa     4920

agcattctat gtgtggaaca ctctgctaga tgctgtggat ttagaaatga aaatacatcc     4980

cgacccttgg aatggaaggg aaaggactga agtaagacag attaagcagg accgtcagcc     5040

cagcttgaag cccagataaa tacggagaac aagagagagc gagtagtgag agatgagtcc     5100

caatgcctca ctttggtgac gggtgcgtgg tgggcttcat gcagcttctt ctgataaatg     5160

cctccttcag aactggtcaa ctctaccttg gccagtgacc caggtggtca tagtagattt     5220

accaagggaa aatggaaact tttattagga gctcttaggc ctcttcactt catggatttt     5280

tttttccttt ttttttgaga tggagttttg ccctgtcacc caggctggaa tgcagtggtg     5340

caatctcagc tcactgcaac ctccgcctcc caggttcaag caattctcct gcctcagcct     5400

cccgagtagc tgggactaca ggtgtgcgcc accacaccag gctaattttt gtattttttg     5460

taaagacagg ttttcaccac gttggccagg ctggtctgaa ctccagacct caggtgattc     5520

acctgtctca gcctcccaaa gtgctgggat tacaggtgtg agccaccgtg cccggctact     5580

tcatggattt ttgattacag attatgcctc ttacaatttt taagaagaat caagtgggct     5640

gaaggtcaat gtcaccataa gacaaaagac atttttatta gttgattcta gggaattggc     5700

cttaagggga gccctttctt cctaagagat tcttaggtga ttctcacttc ctcttgcccc     5760

agtattattt ttgtttttgg tatggctcac tcagatcctt ttttcctcct atccctaagt     5820

aatccgggtt tctttttccc atatttagaa caaaatgtat ttatgcagag tgtgtccaaa     5880

cctcaaccca aggcctgtat acaaaataaa tcaaattaaa cacatcttta ctgtcttcta     5940

cctctttcct gacctcaata tatcccaact tgcctcactc tgagaaccaa ggctgtccca     6000

gcacctgagt cgcagatatt ctactgattt gacagaactg tgtgactatc tggaacagca     6060

ttttgatcca caatttgccc agttacaaag cttaaatgag ctctagtgca tgcatatata     6120

tttcaaaatt ccaccatgat cttccacact ctgtattgta aatagagccc tgtaatgctt     6180

ttacttcgta tttcattgct tgttatacat aaaaatatac ttttcttctt catgttagaa     6240

aatgcaaaga ataggagggt gggggaatct ctgggcttgg agacaggaga cttgccttcc     6300

tactatggtt ccatcagaat gtagactggg acaatacaat aattcaagtc tggtttgctc     6360

atctgtaaat tgggaagaat gtttccagct ccagaatgct aaatctctaa gtctgtggtt     6420

ggcagccact attgcagcag ctcttcaatg actcaatgca gttttgcatt ctccctacct     6480

tttttttcta aaaccaataa aatagataca gcctttaggc tttctgggat ttcccttagt     6540

caagctaggg tcatcctgac tttcggcgtg aatttgcaaa acaagacctg actctgtact     6600

cctgctctaa ggactgtgca tggttccaaa ggcttagctt gccagcatat ttgagctttt     6660

tccttctgtt caaactgttc caaaatataa aagaataaaa ttaattaagt tggcactgga     6720

cttccggtgg tcagtcatgt gtgtcatctg tcacgttttt cgggctctgg tggaaatgga     6780

tctgtctgtc ttctctcata ggtggtattc acagccaacg actccggccc ccgccgctac     6840

accattgccg ccctgctgag cccctactcc tattccacca cggctgtcgt caccaatccc     6900

aaggaatgag ggacttctcc tccagtggac ctgaaggacg agggatggga tttcatgtaa     6960

ccaagagtat tccattttta ctaaagcagt gttttcacct catatgctat gttagaagtc     7020

caggcagaga caataaaaca ttcctgtgaa aggcactttt cattccactt taacttgatt     7080

ttttaaattc ccttattgtc ccttccaaaa aaaagagaat caaaatttta caaagaatca     7140

aaggaattct agaaagtatc tgggcagaac gctaggagag atccaaattt ccattgtctt     7200

gcaagcaaag cacgtattaa atatgatctg cagccattaa aaagacacat tctgtaaa       7258


<210>  13
<211>  147
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  Signal Peptide

<400>  13

Met Ala Ser Leu Arg Leu Phe Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Ala Gly Ala Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val 
        35                  40                  45              


Ala Val Lys Val Phe Lys Lys Thr Ser Glu Gly Ser Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Asp Glu Lys Phe Val Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Thr Leu Gly Ile Ser Pro Phe His Glu Phe Ala Asp 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn 
    130                 135                 140                 


Pro Gln Asn 
145         


<210>  14
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Ser Leu Arg Leu Phe Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala 
            20  


<210>  15
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Pro Ala Gly Ala Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val Ala Val Lys Val 
            20                  25                  30          


Phe Lys Lys Thr Ser Glu Gly Ser Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr Asp Glu Lys Phe 
    50                  55                  60                  


Val Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Thr Leu Gly Ile Ser Pro Phe His Glu Phe Ala Asp Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn Pro Gln Asn 
        115                 120                 125         


<210>  16
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Signal Peptide

<400>  16
atggcttccc ttcgactctt cctcctttgc ctcgctggac tggtatttgt gtctgaagct       60

ggccccgcgg gtgctggaga atccaaatgt cctctgatgg tcaaagtcct ggatgctgtc      120

cgaggcagcc ctgctgtaga cgtggctgta aaagtgttca aaaagacctc tgagggatcc      180

tgggagccct ttgcctctgg gaagaccgcg gagtctggag agctgcacgg gctcaccaca      240

gatgagaagt ttgtagaagg agtgtacaga gtagaactgg acaccaaatc gtactggaag      300

acacttggca tttccccgtt ccatgaattc gcggatgtgg ttttcacagc caacgactct      360

ggccatcgcc actacaccat cgcagccctg ctcagcccat actcctacag caccacggct      420

gtcgtcagca acccccagaa ttga                                             444


<210>  17
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atggcttccc ttcgactctt cctcctttgc ctcgctggac tggtatttgt gtctgaagct       60


<210>  18
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
ggccccgcgg gtgctggaga atccaaatgt cctctgatgg tcaaagtcct ggatgctgtc       60

cgaggcagcc ctgctgtaga cgtggctgta aaagtgttca aaaagacctc tgagggatcc      120

tgggagccct ttgcctctgg gaagaccgcg gagtctggag agctgcacgg gctcaccaca      180

gatgagaagt ttgtagaagg agtgtacaga gtagaactgg acaccaaatc gtactggaag      240

acacttggca tttccccgtt ccatgaattc gcggatgtgg ttttcacagc caacgactct      300

ggccatcgcc actacaccat cgcagccctg ctcagcccat actcctacag caccacggct      360

gtcgtcagca acccccagaa ttga                                             384


<210>  19
<211>  1237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ctaatctccc taggcaaggt tcatatttgt gtaggttact tattctcctt ttgttgacta       60

agtcaataat cagaatcagc aggtttggag tcagcttggc agggatcagc agcctgggtt      120

ggaaggaggg ggtataaaag ccccttcacc aggagaagcc gtcacacaga tccacaagct      180

cctgacagga tggcttccct tcgactcttc ctcctttgcc tcgctggact ggtatttgtg      240

tctgaagctg gccccgcggg tgctggagaa tccaaatgtc ctctgatggt caaagtcctg      300

gatgctgtcc gaggcagccc tgctgtagac gtggctgtaa aagtgttcaa aaagacctct      360

gagggatcct gggagccctt tgcctctggg aagaccgcgg agtctggaga gctgcacggg      420

ctcaccacag atgagaagtt tgtagaagga gtgtacagag tagaactgga caccaaatcg      480

tactggaaga cacttggcat ttccccgttc catgaattcg cggatgtggt tttcacagcc      540

aacgactctg gccatcgcca ctacaccatc gcagccctgc tcagcccata ctcctacagc      600

accacggctg tcgtcagcaa cccccagaat tgagagactc agcccaggag gaccaggatc      660

ttgccaaagc agtagcatcc catttgtacc aaaacagtgt tcttgctcta taaaccgtgt      720

tagcagctca ggaagatgcc gtgaagcatt cttattaaac cacctgctat ttcattcaaa      780

ctgtgtttct tttttatttc ctcatttttc tcccctgctc ctaaaaccca aaatcttcta      840

aagaattcta gaaggtatgc gatcaaactt tttaaagaaa gaaaatactt tttgactcat      900

ggtttaaagg catcctttcc atcttgggga ggtcatgggt gctcctggca acttgcttga      960

ggaagatagg tcagaaagca gagtggacca accgttcaat gttttacaag caaaacatac     1020

actaagcatg gtctgtagct attaaaagca cacaatctga agggctgtag atgcacagta     1080

gtgttttccc agagcatgtt caaaagccct gggttcaatc acaatactga aaagtaggcc     1140

aaaaaacatt ctgaaaatga aatatttggg ttttttttta taacctttag tgactaaata     1200

aagacaaatc taagagacta aaaaaaaaaa aaaaaaa                              1237


<210>  20
<211>  9077
<212>  DNA
<213>  Mus musculus

<400>  20
ctaatctccc taggcaaggt tcatatttgt gtaggttact tattctcctt ttgttgacta       60

agtcaataat cagaatcagc aggtttggag tcagcttggc agggatcagc agcctgggtt      120

ggaaggaggg ggtataaaag ccccttcacc aggagaagcc gtcacacaga tccacaagct      180

cctgacagga tggcttccct tcgactcttc ctcctttgcc tcgctggact ggtatttgtg      240

tctgaagctg gccccgcggt gagtgatcct gtgagcgatc cagacatggc agttagacct      300

tagataaaga agaagtgcct tcttccagat gtgagaacta gagtactcag actctatatt      360

taccattaga ctccaaagag aagagctgga gtgcctctgg ctcttccttc tattgcttta      420

gcgcattggg tctgtagtgc tcagtctctg gtgtccttag ataataaaga tatgagatta      480

acatagaaat aaagatataa aagggctgga tgtatagttt agtggtccag tgtatgccta      540

gtatgtgaaa agccttctgt tcaacctcta gcaatagaaa aacaagatat attctcggtg      600

gggctgttaa tattgaattc tcataaaatc tttaatatat ttagtatgcc tattatgttg      660

ttatatttta gttctttagc taatcaaaat gcattattga tctttctttg tctttttttg      720

gccaacactc tattccagtc tttgaaaaag tcctttaaaa gagttaatca gtataattaa      780

atgagtcagg aagtatgtga gggttatttt acaaccagag ggaattacta tagcaacagc      840

tgattagaat gatctcaaga aaaagcccat tctgtctttt tgcaccatgc acctttcagt      900

ggctccattc agatggagag gcaaacagag caatggctct cagagggcct attttccctt      960

tgaacattca ttatccatat ccctggtgca cagcagtgca tctgggggca gaaactgttc     1020

ttgctttgga aacaatgctg tctatgtcat actggataaa gaagctcatt aattgtcaac     1080

acttatgtta tcataatggg atcagcatgt acttttggtt ttgttccaga gtctatcacc     1140

ggaaagaaca agccggttta ctctgaccca tttcactgac atttctcttg tctcctctgt     1200

gcccagggtg ctggagaatc caaatgtcct ctgatggtca aagtcctgga tgctgtccga     1260

ggcagccctg ctgtagacgt ggctgtaaaa gtgttcaaaa agacctctga gggatcctgg     1320

gagccctttg cctctgggta agcttgtaga aagcccacca tgggaccggt tccaggttcc     1380

catttgctct tattcgtgtt agattcagac acacacaact taccagctag agggctcaga     1440

gagagggctc aggggcgaag ggcacgtatt gctcttgtaa gagacacagg tttaattcct     1500

agcaccagaa tggcagctca taaccatctg aaactcacag tcttaggaga tctgggtatc     1560

tgacattctc ttctacccac catgtgtgtg gtgcacaaat tcacatgcag gcatcaaatc     1620

ttataaacaa caacaaaaaa ccaacaaacc tggtagcaaa agaagattag aaggttaaac     1680

atatgagccg agagcttttg ttttgttttg ttttgttttg ttttgtttac atttcaaatg     1740

ttatcccctt tctcggtccc cctccccaaa ccctctaccc cattctctcc tccccttctt     1800

ctatgagggt gttccccacc aacccactcc caccttcctg ctctcgaatt cccctatact     1860

gggacatcaa gccttcacag aatcaagggc ctctcctccc attgatgccc gacaatgtca     1920

tcctctgcta cctatgtggc tggagccatg ggtcccttca tgtatcctcc ttggttggtg     1980

gtttagtctc tgggaggtct gggggatctg gttgattgat attattgttc ttcctatgag     2040

attgcaaacc ccttcagctc cttcggtcct ttaactcctc cactggggac cccgagctca     2100

gtccaatggt tggctgtgag catccaccag cagaggcctt tttttttttt tttaacaaag     2160

ctgctttatt atgttgctta gagcatgacc aggaaccaga gcacagtcca agactgaagg     2220

gaggaaaagg gggggagtca ataaccccac tgtttcatag tggtttgcaa cccttttata     2280

tcacagccca ctttaggcaa ataatgaaaa ttatagtctc cagggacaga gaagatggtg     2340

caggaagtga agtgcctgct cagaaaatgg gggcttgaat gtgagttccc agactctgtg     2400

taagatgccc agcatcgaag tgcatgctta taacaccagc ctggaggtag aagcttagaa     2460

acaggggtac cctgaagttg cttgttcacc agtgtccctg aatgggtagg tgcatgtttg     2520

gtgagagacc ctgtctcaaa aatcaaggtg taggataatt gaaaatacct agctttgagc     2580

ttagatcatg caaatgtgta cacacactca cacacaccac acacacaaaa aaatgcagag     2640

acagagagat acagagagac agagagatac agagacagag acagagagaa aaggagaaag     2700

taaaaaacaa ataatttaaa gacccatggc cacaaagagg ctcaaagaca agcacgtata     2760

aaaccataca catgtaattt taggagtttt cagattccct ggtacccgtg ggtgatgcac     2820

aagctttgaa tcccagtctt aaaatcttac gaagaacgtg ttcgtgtgtg ctaatttatt     2880

gatgagagga aaggaattga caaagtgccc ttccggagct tcctgcatta cccagactca     2940

gggttttttt aaatgtacac tcagaacaga gtagctctgt gcaagggtag caaccacgaa     3000

gcttaataag aaacatatcg tgagagatct gcaaggcaaa tctaggggct gaccaatctc     3060

acagtcaccc actagcatgt caacacaact tcccacctgt gctagccact tagcaatttt     3120

gtgttgttct gttttgtttt tgtttttaac aaagcaattt caaagagatt tctaattcat     3180

ctaaacaaac aaaccaaaag gaaaacagca aagacgccct gagcacttag cagagcagct     3240

atgcagttat gactcctggg tggagacttt atatcaggct tcaactgaat acctagaacc     3300

tactagtgct cttcatcaat ccttgggaag gtcattttct tttggtgctg ttttgagttt     3360

ctatttgtta atgtcttcat aattatacac gtgttgagca cagcatgcaa agtgattagg     3420

ggaatctagt tggagtggaa tggataccca aatattcaga ctttcttgtg actcttcttt     3480

cttgtaccca catcaaaaaa aaaaaaaatg gagatgagac atggtcagag tcactaaaac     3540

cagctgctac ttttaattac gtggggagca gtttctaaca ttgccattat tgaactgatg     3600

ctgcctgggt ggaaatggaa atcacttagt atttcttgtt ggcaaagaat tactgaatgg     3660

attaaatttc caaagggaga agtcagttac aagtcttttc tttgtttatt aggctttctg     3720

ctatgataaa ttacactact tccagaagtt acccttaggc catgggacac tggactatca     3780

ctctgctgtc acaagagatt acagagttag tcaaggcagc ttgtgacacc ttcagggact     3840

gtcataaact tccagcaagt cattaatcct gaatgcaata ctgtgtgtgt gtgtctatgt     3900

gtgtttgtat gtctgtgtgt gtcttatgtc tgtgtctctg tgtgtgtgtg tgtttgtgtg     3960

tgtgtgtgta tgtatgcctg tgtgtgtctt atgtctgtgt ttgtgtgtct gtgtgtgtct     4020

tatgtctgtg tttgtatgtc tgtgtgtgtc tgtgtgtgtc ttatgtctgt gtctctgtgt     4080

gtgtgtgtgt gtatgtatgt atgtatgtat gtatgtgtat gtgtttgcat ctctctgtgt     4140

gtctgcgctt atatatttgt gtatgtgttt atgtgttcgc ctttgtgcgt tgttggggat     4200

tgaatccagg ggaatacaaa tgttaagaaa gaacgttacc actaagcttc acctgtaggc     4260

cttaaagctt ttctttcttt taaaaattgt aattaattca ttttcagtca ggatctccac     4320

acctcgtccc tgctgctcta gaactcacta tttaaacaca atcgccctca aacctgcagc     4380

aaccctcccg cctctaccct gcgagcacta gaataataac aggtgacccc acacgcctag     4440

attaagacct ttaaggtaaa cattttacta tattttagtc tcataagaca agatgctaca     4500

ataaagctgt acataaagtt ccctcgaatt tcttgctatt ttaactcaaa cataaggatt     4560

tcctcctttt tgattcaggt aacagaaaaa atacacaggt acatacatgt acacacatga     4620

acacacacgc atcacaacca catatgcgca cgcttgtgtg atctatcatt taccatgcca     4680

ctgaactctt ctttccccat aaattcctct ggacttgtgt gccctccagg aagaccgcgg     4740

agtctggaga gctgcacggg ctcaccacag atgagaagtt tgtagaagga gtgtacagag     4800

tagaactgga caccaaatcg tactggaaga cacttggcat ttccccgttc catgaattcg     4860

cggatgtaag tggacacacc aagttgtttg gattttgttt ttagtctcag gaaattccct     4920

tcgctcttgc tgtacgatgg gcatgagtgg aaagtagatt ccacagccag aatccacagt     4980

gctgggaaag caagccttct gaatttttct aaaactcatt tagcaacatg gcctgaacct     5040

gttcacactg cttatggtca gctaactata tttatgtaaa tattcatttc tctgttgagg     5100

aaatgttagt atttgctttt gaggcaacct ccagatacca tggagggcat gtcatagtca     5160

aagagagggc tccctatggt atttctctaa attctggcat ttcctttatt ccaaagcaca     5220

tctagtgtcc ccagaagttt gggtagacaa ttcttggcaa cacagagaat tacaacatgt     5280

tcaaaaccca acagcttaat atctaaatca tcaagcaaac atcacatggc aaagggattt     5340

ctgaatcaaa actgtttcat ccttatgatc aacctatgga ggtctagcct cgacttacac     5400

ccattttacc aataagctaa gagaagctaa gttcctcatc aaggacacaa ggctagcatg     5460

tgtgagcaag tgacagagtt gccctctatg ttggttagtg tgccttagcc agtgtctcag     5520

taagaaatgg agctaaatca aaacccaagg ccaacagcca aaggcacatg agtaaccttt     5580

gcttggcact gggctcagtt tccctggctc ctctcagtcc tcagttcaca gaggcagctg     5640

tcatgcaaat agaatccaag cttgttggtc agacctggag ataacaaatt ccatcaaaaa     5700

tagctcctca tgtgacctag tttgctgtct gttgctatga tacacaccat gaccgaaaag     5760

caaccctggg gagagaaggg tttatttcat cttacagctt acagttcacc atggaggaaa     5820

gccaggtggg aacctggaag tggaaattga agcagagacc agaaaggaat gctgtttact     5880

ggctggctta gctccttttc ttatacagct taggtctatg tgcccagggg atggtactgc     5940

cgagcatagg ctgagcccgc ctacatcaac cattagtcaa aaaaaggtcc atagacttgc     6000

ctacaggcca atctcatgga ggcaataccc cagtggaggg tccctcttcg caggttactc     6060

tagtttgtgt caagttgaca aaacctaacc acaaagcaca aacagggtct gcccttgtgg     6120

cttagccatg gatgacactc tcagatgatg gtgttaccag acaaaccaga ggggctcacc     6180

aagagtctgc cacctaccaa ggtagtactc tactcctcac tgggcaccaa cacccatatt     6240

agctgggcca gtacaggacc cttgctgttt cctgcatgaa ttgtccatag accctgggtc     6300

tcagcctgcc gggagtacct gtaagtagtc gcctcaaaca cattattcct gttggaagac     6360

ttgtctgatt ctcttttaga actcaatcaa caaacgtttt tattttgttt tggctttttg     6420

gagacaagat ctctcatagg ccagcctgac ttgaatgtag ctgaggatga cctgtgctgc     6480

taatcttctc gcctcttcct cccaagtggt aggataatag gcataagaca ccacagcagt     6540

tttactccat accagggctc tgaacccaga ctttaaacac tctatcaact gattcacatt     6600

cccaccccat cattcaacaa acatttgaaa aataaaaccc ttctgccttg agcactctgc     6660

taaatacagc ctttgagtgc ggagtatttc ctcacaacca gggtccaaga tgaccccatc     6720

atacatacca cggaaaatta ggagatgttt ttaggtctct ttgcttgggg taatttttat     6780

gtgtgtgtgt acacagccct gtgcgtgtgt gtgtgtgtgt gtgtgtgtgt gtacaggcac     6840

acacgtgtat gcatgtagag gctacataaa aaccttaggt gtcattctca ggcactctgt     6900

tcaccccttc acacagcccg aacacacaaa atttgaggca ttagcctgga gctcaccagt     6960

taggctagac tgacttgcca gcagacccca ggctgtctcc atctccccag ctctgggatt     7020

acaaactcta tcataccaga catttttata catattctga gcataaaatt catgtcttca     7080

ggctaacaag tcaagagctt aaatgactga gctctcttac gtggtggatt ttttttaaaa     7140

ctacataata tctttttttt ttttttcact tctggggaag aaacaaatga gcctgagtga     7200

caatgcgaca gaaaagaaat tttgaggagt gtgtgtgtct gtgtgtgtgg tggcacatgc     7260

ctctcatcta atgctagagg ctacagtaga atgctcctga attagtggcc agccaaggcc     7320

aagggctagg gttgtaactc agtggcagag ggcttgccta gcattcgcag gatttgatcc     7380

atagcgctat aaataataat aaataaatac aacagtctaa gatgattctc cctttcattt     7440

atctggatgt tatttttgtg ttagttttac tctgtcatcc aatcattgtt tgccctatat     7500

ttggacattt aaaaaaaatc tttattccaa gtgtgttcaa agctgtatcc aaaacctgtc     7560

caccaaatga gtccaatgac atacatcttc tatattacca tctgttccag atttggctga     7620

ctcccggcac ctgggctgtt gctgcaccca tgtctcagat agtctagtga tttgagaagt     7680

gactagtaat tgcaaaatcc agactttgtc cagaaacttc tatgagctcc aaaactttca     7740

tttacatttc tgccagccac aaaccgcttg tgttgtggag agaaccctgt gatgtcttcc     7800

cacagcatct cagccttgtt tcttccctta aaatattcat cttttcacat tagaacatgc     7860

aaagggacag tgggagcgaa acccctggac tgggacgcac gaagccttcc tttctggtca     7920

ggctctcact gtagaaactt aggccggttt cagcatgcag tctgctggag aatggctcct     7980

gccaacattc caggtctgga agtttgtagt ggagttgttg ataaccactg ttcgccacag     8040

gtcttttgtt tgtgggtgtc agtgtttcta ctctcctgac ttttatctga acccaagaaa     8100

gggaacaata gccttcaagc tctctgtgac tctgatctga ccagggccac ccacactgca     8160

gaaggaaact tgcaaagaga gacctgcaat tctctaagag ctccacacag ctccaaagac     8220

ttaggcagca tattttaatc taattattcg tcccccaacc ccaccccaga ggacagttag     8280

acaataaaag gaagattacc agcttagcat cctgtgaaca ctttgtctgc agctcctacc     8340

tctgggctct gttagaacta gctgtctctc ctctctccta ggtggttttc acagccaacg     8400

actctggcca tcgccactac accatcgcag ccctgctcag cccatactcc tacagcacca     8460

cggctgtcgt cagcaacccc cagaattgag agactcagcc caggaggacc aggatcttgc     8520

caaagcagta gcatcccatt tgtaccaaaa cagtgttctt gctctataaa ccgtgttagc     8580

agctcaggaa gatgccgtga agcattctta ttaaaccacc tgctatttca ttcaaactgt     8640

gtttcttttt tatttcctca tttttctccc ctgctcctaa aacccaaaat cttctaaaga     8700

attctagaag gtatgcgatc aaacttttta aagaaagaaa atactttttg actcatggtt     8760

taaaggcatc ctttccatct tggggaggtc atgggtgctc ctggcaactt gcttgaggaa     8820

gataggtcag aaagcagagt ggaccaaccg ttcaatgttt tacaagcaaa acatacacta     8880

agcatggtct gtagctatta aaagcacaca atctgaaggg ctgtagatgc acagtagtgt     8940

tttcccagag catgttcaaa agccctgggt tcaatcacaa tactgaaaag taggccaaaa     9000

aacattctga aaatgaaata tttgggtttt tttttataac ctttagtgac taaataaaga     9060

caaatctaag agactaa                                                    9077


<210>  21
<211>  8300
<212>  DNA
<213>  Mus musculus

<400>  21
atggcttccc ttcgactctt cctcctttgc ctcgctggac tggtatttgt gtctgaagct       60

ggccccgcgg tgagtgatcc tgtgagcgat ccagacatgg cagttagacc ttagataaag      120

aagaagtgcc ttcttccaga tgtgagaact agagtactca gactctatat ttaccattag      180

actccaaaga gaagagctgg agtgcctctg gctcttcctt ctattgcttt agcgcattgg      240

gtctgtagtg ctcagtctct ggtgtcctta gataataaag atatgagatt aacatagaaa      300

taaagatata aaagggctgg atgtatagtt tagtggtcca gtgtatgcct agtatgtgaa      360

aagccttctg ttcaacctct agcaatagaa aaacaagata tattctcggt ggggctgtta      420

atattgaatt ctcataaaat ctttaatata tttagtatgc ctattatgtt gttatatttt      480

agttctttag ctaatcaaaa tgcattattg atctttcttt gtcttttttt ggccaacact      540

ctattccagt ctttgaaaaa gtcctttaaa agagttaatc agtataatta aatgagtcag      600

gaagtatgtg agggttattt tacaaccaga gggaattact atagcaacag ctgattagaa      660

tgatctcaag aaaaagccca ttctgtcttt ttgcaccatg cacctttcag tggctccatt      720

cagatggaga ggcaaacaga gcaatggctc tcagagggcc tattttccct ttgaacattc      780

attatccata tccctggtgc acagcagtgc atctgggggc agaaactgtt cttgctttgg      840

aaacaatgct gtctatgtca tactggataa agaagctcat taattgtcaa cacttatgtt      900

atcataatgg gatcagcatg tacttttggt tttgttccag agtctatcac cggaaagaac      960

aagccggttt actctgaccc atttcactga catttctctt gtctcctctg tgcccagggt     1020

gctggagaat ccaaatgtcc tctgatggtc aaagtcctgg atgctgtccg aggcagccct     1080

gctgtagacg tggctgtaaa agtgttcaaa aagacctctg agggatcctg ggagcccttt     1140

gcctctgggt aagcttgtag aaagcccacc atgggaccgg ttccaggttc ccatttgctc     1200

ttattcgtgt tagattcaga cacacacaac ttaccagcta gagggctcag agagagggct     1260

caggggcgaa gggcacgtat tgctcttgta agagacacag gtttaattcc tagcaccaga     1320

atggcagctc ataaccatct gaaactcaca gtcttaggag atctgggtat ctgacattct     1380

cttctaccca ccatgtgtgt ggtgcacaaa ttcacatgca ggcatcaaat cttataaaca     1440

acaacaaaaa accaacaaac ctggtagcaa aagaagatta gaaggttaaa catatgagcc     1500

gagagctttt gttttgtttt gttttgtttt gttttgttta catttcaaat gttatcccct     1560

ttctcggtcc ccctccccaa accctctacc ccattctctc ctccccttct tctatgaggg     1620

tgttccccac caacccactc ccaccttcct gctctcgaat tcccctatac tgggacatca     1680

agccttcaca gaatcaaggg cctctcctcc cattgatgcc cgacaatgtc atcctctgct     1740

acctatgtgg ctggagccat gggtcccttc atgtatcctc cttggttggt ggtttagtct     1800

ctgggaggtc tgggggatct ggttgattga tattattgtt cttcctatga gattgcaaac     1860

cccttcagct ccttcggtcc tttaactcct ccactgggga ccccgagctc agtccaatgg     1920

ttggctgtga gcatccacca gcagaggcct tttttttttt ttttaacaaa gctgctttat     1980

tatgttgctt agagcatgac caggaaccag agcacagtcc aagactgaag ggaggaaaag     2040

ggggggagtc aataacccca ctgtttcata gtggtttgca acccttttat atcacagccc     2100

actttaggca aataatgaaa attatagtct ccagggacag agaagatggt gcaggaagtg     2160

aagtgcctgc tcagaaaatg ggggcttgaa tgtgagttcc cagactctgt gtaagatgcc     2220

cagcatcgaa gtgcatgctt ataacaccag cctggaggta gaagcttaga aacaggggta     2280

ccctgaagtt gcttgttcac cagtgtccct gaatgggtag gtgcatgttt ggtgagagac     2340

cctgtctcaa aaatcaaggt gtaggataat tgaaaatacc tagctttgag cttagatcat     2400

gcaaatgtgt acacacactc acacacacca cacacacaaa aaaatgcaga gacagagaga     2460

tacagagaga cagagagata cagagacaga gacagagaga aaaggagaaa gtaaaaaaca     2520

aataatttaa agacccatgg ccacaaagag gctcaaagac aagcacgtat aaaaccatac     2580

acatgtaatt ttaggagttt tcagattccc tggtacccgt gggtgatgca caagctttga     2640

atcccagtct taaaatctta cgaagaacgt gttcgtgtgt gctaatttat tgatgagagg     2700

aaaggaattg acaaagtgcc cttccggagc ttcctgcatt acccagactc agggtttttt     2760

taaatgtaca ctcagaacag agtagctctg tgcaagggta gcaaccacga agcttaataa     2820

gaaacatatc gtgagagatc tgcaaggcaa atctaggggc tgaccaatct cacagtcacc     2880

cactagcatg tcaacacaac ttcccacctg tgctagccac ttagcaattt tgtgttgttc     2940

tgttttgttt ttgtttttaa caaagcaatt tcaaagagat ttctaattca tctaaacaaa     3000

caaaccaaaa ggaaaacagc aaagacgccc tgagcactta gcagagcagc tatgcagtta     3060

tgactcctgg gtggagactt tatatcaggc ttcaactgaa tacctagaac ctactagtgc     3120

tcttcatcaa tccttgggaa ggtcattttc ttttggtgct gttttgagtt tctatttgtt     3180

aatgtcttca taattataca cgtgttgagc acagcatgca aagtgattag gggaatctag     3240

ttggagtgga atggataccc aaatattcag actttcttgt gactcttctt tcttgtaccc     3300

acatcaaaaa aaaaaaaaat ggagatgaga catggtcaga gtcactaaaa ccagctgcta     3360

cttttaatta cgtggggagc agtttctaac attgccatta ttgaactgat gctgcctggg     3420

tggaaatgga aatcacttag tatttcttgt tggcaaagaa ttactgaatg gattaaattt     3480

ccaaagggag aagtcagtta caagtctttt ctttgtttat taggctttct gctatgataa     3540

attacactac ttccagaagt tacccttagg ccatgggaca ctggactatc actctgctgt     3600

cacaagagat tacagagtta gtcaaggcag cttgtgacac cttcagggac tgtcataaac     3660

ttccagcaag tcattaatcc tgaatgcaat actgtgtgtg tgtgtctatg tgtgtttgta     3720

tgtctgtgtg tgtcttatgt ctgtgtctct gtgtgtgtgt gtgtttgtgt gtgtgtgtgt     3780

atgtatgcct gtgtgtgtct tatgtctgtg tttgtgtgtc tgtgtgtgtc ttatgtctgt     3840

gtttgtatgt ctgtgtgtgt ctgtgtgtgt cttatgtctg tgtctctgtg tgtgtgtgtg     3900

tgtatgtatg tatgtatgta tgtatgtgta tgtgtttgca tctctctgtg tgtctgcgct     3960

tatatatttg tgtatgtgtt tatgtgttcg cctttgtgcg ttgttgggga ttgaatccag     4020

gggaatacaa atgttaagaa agaacgttac cactaagctt cacctgtagg ccttaaagct     4080

tttctttctt ttaaaaattg taattaattc attttcagtc aggatctcca cacctcgtcc     4140

ctgctgctct agaactcact atttaaacac aatcgccctc aaacctgcag caaccctccc     4200

gcctctaccc tgcgagcact agaataataa caggtgaccc cacacgccta gattaagacc     4260

tttaaggtaa acattttact atattttagt ctcataagac aagatgctac aataaagctg     4320

tacataaagt tccctcgaat ttcttgctat tttaactcaa acataaggat ttcctccttt     4380

ttgattcagg taacagaaaa aatacacagg tacatacatg tacacacatg aacacacacg     4440

catcacaacc acatatgcgc acgcttgtgt gatctatcat ttaccatgcc actgaactct     4500

tctttcccca taaattcctc tggacttgtg tgccctccag gaagaccgcg gagtctggag     4560

agctgcacgg gctcaccaca gatgagaagt ttgtagaagg agtgtacaga gtagaactgg     4620

acaccaaatc gtactggaag acacttggca tttccccgtt ccatgaattc gcggatgtaa     4680

gtggacacac caagttgttt ggattttgtt tttagtctca ggaaattccc ttcgctcttg     4740

ctgtacgatg ggcatgagtg gaaagtagat tccacagcca gaatccacag tgctgggaaa     4800

gcaagccttc tgaatttttc taaaactcat ttagcaacat ggcctgaacc tgttcacact     4860

gcttatggtc agctaactat atttatgtaa atattcattt ctctgttgag gaaatgttag     4920

tatttgcttt tgaggcaacc tccagatacc atggagggca tgtcatagtc aaagagaggg     4980

ctccctatgg tatttctcta aattctggca tttcctttat tccaaagcac atctagtgtc     5040

cccagaagtt tgggtagaca attcttggca acacagagaa ttacaacatg ttcaaaaccc     5100

aacagcttaa tatctaaatc atcaagcaaa catcacatgg caaagggatt tctgaatcaa     5160

aactgtttca tccttatgat caacctatgg aggtctagcc tcgacttaca cccattttac     5220

caataagcta agagaagcta agttcctcat caaggacaca aggctagcat gtgtgagcaa     5280

gtgacagagt tgccctctat gttggttagt gtgccttagc cagtgtctca gtaagaaatg     5340

gagctaaatc aaaacccaag gccaacagcc aaaggcacat gagtaacctt tgcttggcac     5400

tgggctcagt ttccctggct cctctcagtc ctcagttcac agaggcagct gtcatgcaaa     5460

tagaatccaa gcttgttggt cagacctgga gataacaaat tccatcaaaa atagctcctc     5520

atgtgaccta gtttgctgtc tgttgctatg atacacacca tgaccgaaaa gcaaccctgg     5580

ggagagaagg gtttatttca tcttacagct tacagttcac catggaggaa agccaggtgg     5640

gaacctggaa gtggaaattg aagcagagac cagaaaggaa tgctgtttac tggctggctt     5700

agctcctttt cttatacagc ttaggtctat gtgcccaggg gatggtactg ccgagcatag     5760

gctgagcccg cctacatcaa ccattagtca aaaaaaggtc catagacttg cctacaggcc     5820

aatctcatgg aggcaatacc ccagtggagg gtccctcttc gcaggttact ctagtttgtg     5880

tcaagttgac aaaacctaac cacaaagcac aaacagggtc tgcccttgtg gcttagccat     5940

ggatgacact ctcagatgat ggtgttacca gacaaaccag aggggctcac caagagtctg     6000

ccacctacca aggtagtact ctactcctca ctgggcacca acacccatat tagctgggcc     6060

agtacaggac ccttgctgtt tcctgcatga attgtccata gaccctgggt ctcagcctgc     6120

cgggagtacc tgtaagtagt cgcctcaaac acattattcc tgttggaaga cttgtctgat     6180

tctcttttag aactcaatca acaaacgttt ttattttgtt ttggcttttt ggagacaaga     6240

tctctcatag gccagcctga cttgaatgta gctgaggatg acctgtgctg ctaatcttct     6300

cgcctcttcc tcccaagtgg taggataata ggcataagac accacagcag ttttactcca     6360

taccagggct ctgaacccag actttaaaca ctctatcaac tgattcacat tcccacccca     6420

tcattcaaca aacatttgaa aaataaaacc cttctgcctt gagcactctg ctaaatacag     6480

cctttgagtg cggagtattt cctcacaacc agggtccaag atgaccccat catacatacc     6540

acggaaaatt aggagatgtt tttaggtctc tttgcttggg gtaattttta tgtgtgtgtg     6600

tacacagccc tgtgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtacaggca cacacgtgta     6660

tgcatgtaga ggctacataa aaaccttagg tgtcattctc aggcactctg ttcacccctt     6720

cacacagccc gaacacacaa aatttgaggc attagcctgg agctcaccag ttaggctaga     6780

ctgacttgcc agcagacccc aggctgtctc catctcccca gctctgggat tacaaactct     6840

atcataccag acatttttat acatattctg agcataaaat tcatgtcttc aggctaacaa     6900

gtcaagagct taaatgactg agctctctta cgtggtggat tttttttaaa actacataat     6960

atcttttttt tttttttcac ttctggggaa gaaacaaatg agcctgagtg acaatgcgac     7020

agaaaagaaa ttttgaggag tgtgtgtgtc tgtgtgtgtg gtggcacatg cctctcatct     7080

aatgctagag gctacagtag aatgctcctg aattagtggc cagccaaggc caagggctag     7140

ggttgtaact cagtggcaga gggcttgcct agcattcgca ggatttgatc catagcgcta     7200

taaataataa taaataaata caacagtcta agatgattct ccctttcatt tatctggatg     7260

ttatttttgt gttagtttta ctctgtcatc caatcattgt ttgccctata tttggacatt     7320

taaaaaaaat ctttattcca agtgtgttca aagctgtatc caaaacctgt ccaccaaatg     7380

agtccaatga catacatctt ctatattacc atctgttcca gatttggctg actcccggca     7440

cctgggctgt tgctgcaccc atgtctcaga tagtctagtg atttgagaag tgactagtaa     7500

ttgcaaaatc cagactttgt ccagaaactt ctatgagctc caaaactttc atttacattt     7560

ctgccagcca caaaccgctt gtgttgtgga gagaaccctg tgatgtcttc ccacagcatc     7620

tcagccttgt ttcttccctt aaaatattca tcttttcaca ttagaacatg caaagggaca     7680

gtgggagcga aacccctgga ctgggacgca cgaagccttc ctttctggtc aggctctcac     7740

tgtagaaact taggccggtt tcagcatgca gtctgctgga gaatggctcc tgccaacatt     7800

ccaggtctgg aagtttgtag tggagttgtt gataaccact gttcgccaca ggtcttttgt     7860

ttgtgggtgt cagtgtttct actctcctga cttttatctg aacccaagaa agggaacaat     7920

agccttcaag ctctctgtga ctctgatctg accagggcca cccacactgc agaaggaaac     7980

ttgcaaagag agacctgcaa ttctctaaga gctccacaca gctccaaaga cttaggcagc     8040

atattttaat ctaattattc gtcccccaac cccaccccag aggacagtta gacaataaaa     8100

ggaagattac cagcttagca tcctgtgaac actttgtctg cagctcctac ctctgggctc     8160

tgttagaact agctgtctct cctctctcct aggtggtttt cacagccaac gactctggcc     8220

atcgccacta caccatcgca gccctgctca gcccatactc ctacagcacc acggctgtcg     8280

tcagcaaccc ccagaattga                                                 8300


<210>  22
<211>  11842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (98)..(7216)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (7217)..(11742)
<223>  Cassette Sequence

<220>
<221>  misc_feature
<222>  (11743)..(11842)
<223>  Mouse Sequence

<400>  22
agcttggcag ggatcagcag cctgggttgg aaggaggggg tataaaagcc ccttcaccag       60

gagaagccgt cacacagatc cacaagctcc tgacaggatg gcttctcatc gtctgctcct      120

cctctgcctt gctggactgg tatttgtgtc tgaggctggc cctacggtga gtgtttctgt      180

gacatcccat tcctacattt aagattcacg ctaaatgaag tagaagtgac tccttccagc      240

tttgccaacc agcttttatt actagggcaa gggtacccag catctatttt taatataatt      300

aattcaaact tcaaaaagaa tgaagttcca ctgagcttac tgagctggga cttgaactct      360

gagcattcta cctcattgct ttggtgcatt aggtttgtaa tatctggtac ctctgtttcc      420

tcagatagat gatagaaata aagatatgat attaaggaag ctgttaatac tgaattttca      480

gaaaagtatc cctccataaa atgtatttgg gggacaaact gcaggagatt atattctggc      540

cctatagtta ttcaaaacgt atttattgat taatctttaa aaggcttagt gaacaatatt      600

ctagtcagat atctaattct taaatcctct agaagaatta actaatacta taaaatgggt      660

ctggatgtag ttctgacatt attttataac aactggtaag agggagtgac tatagcaaca      720

actaaaatga tctcaggaaa acctgtttgg ccctatgtat ggtacattac atcttttcag      780

taattccact caaatggaga cttttaacaa agcaactgtt ctcaggggac ctattttctc      840

ccttaaaatt cattatacac atccctggtt gatagcagtg tgtctggagg cagaaaccat      900

tcttgctttg gaaacaatta cgtctgtgtt atactgagta gggaagctca ttaattgtcg      960

acacttacgt tcctgataat gggatcagtg tgtaattctt gtttcgctcc agatttctaa     1020

taccacaaag aataaatcct ttcactctga tcaattttgt taacttctca cgtgtcttct     1080

ctacacccag ggcaccggtg aatccaagtg tcctctgatg gtcaaagttc tagatgctgt     1140

ccgaggcagt cctgccatca atgtggccat gcatgtgttc agaaaggctg ctgatgacac     1200

ctgggagcca tttgcctctg ggtaagttgc caaagaaccc tcccacagga cttggtttta     1260

tcttcccgtt tgcccctcac ttggtagaga gaggctcaca tcatctgcta aagaatttac     1320

aagtagattg aaaaacgtag gcagaggtca agtatgccct ctgaaggatg ccctcttttt     1380

gttttgctta gctaggaagt gaccaggaac ctgagcatca tttaggggca gacagtagag     1440

aaaagaagga atcagaactc ctctcctcta gctgtggttt gcaacccttt tgggtcacag     1500

aacactttat gtaggtgatg aaaagtaaac attctatgcc cagaaaaaat gcacagatac     1560

acacacatac aaaatcatat atgtgatttt aggagtttca cagattccct ggtgtccctg     1620

ggtaacacca aagctaagtg tccttgtctt agaattttag gaaaaggtat aatgtgtatt     1680

aacccattaa caaaaggaaa ggaattcaga aatattatta accaggcatc tgtctgtagt     1740

taatatggat cacccaaaac ccaaggcttt tgcctaatga acactttggg gcacctactg     1800

tgtgcaaggc tgggggctgt caagctcagt taaaaaaaaa aagatagaag agatggatcc     1860

atgaggcaaa gtacagcccc aggctaatcc cacgatcacc cgacttcatg tccaagagtg     1920

gcttctcacc ttcattagcc agttcacaat tttcatggag tttttctacc tgcactagca     1980

aaaacttcaa ggaaaataca tattaataaa tctaagcaaa gtgaccagaa gacagagcaa     2040

tcaggagacc ctttgcatcc agcagaagag gaactgctaa gtatttacat ctccacagag     2100

aagaatttct gttgggtttt aattgaaccc caagaaccac atgattcttc aaccattatt     2160

gggaagatca ttttcttagg tctggtttta actggctttt tatttgggaa ttcatttatg     2220

tttatataaa atgccaagca taacatgaaa agtggttaca ggactattct aagggagaga     2280

cagaatggac accaaaaata ttccaatgtt cttgtgaatc ttttccttgc accaggacaa     2340

aaaaaaaaag aagtgaaaag aagaaaggag gaggggcata atcagagtca gtaaagacaa     2400

ctgctatttt tatctatcgt agctgttgca gtcaaatggg aagcaatttc caacattcaa     2460

ctatggagct ggtacttaca tggaaataga agttgcctag tgtttgttgc tggcaaagag     2520

ttatcagaga ggttaaatat ataaaaggga aaagagtcag atacaggttc ttcttcctac     2580

tttaggtttt ccactgtgtg tgcaaatgat actccctggt ggtgtgcaga tgcctcaaag     2640

ctatcctcac accacaaggg agaggagcga gatcctgctg tcctggagaa gtgcagagtt     2700

agaacagctg tggccacttg catccaatca tcaatcttga atcacaggga ctctttctta     2760

agtaaacatt atacctggcc gggcacggtg gctcacgcct gtaatcccag cactttggga     2820

tgccaaagtg ggcatatcat ctgaggtcag gagttcaaga ccagcctggc caacatggca     2880

aaactccgtc tttatgaaaa atacaaaaat tagccaggca tggtggcagg cgcctgtaat     2940

cccagctaat tgggaggctg aggctggaga atcccttgaa tctaggaggc agaggttgca     3000

gtgagctgag atcgtgccat tgcactccag cctgggtgac aagagtaaaa ctctgtctca     3060

aaaaaaaaaa attataccta cattctcttc ttatcagaga aaaaaatcta cagtgagctt     3120

ttcaaaaagt ttttacaaac tttttgccat ttaatttcag ttaggagttt tccctacttc     3180

tgacttagtt gaggggaaat gttcataaca tgtttataac atgtttatgt gtgttagttg     3240

gtgggggtgt attactttgc catgccattt gtttcctcca tgcgtaactt aatccagact     3300

ttcacacctt ataggaaaac cagtgagtct ggagagctgc atgggctcac aactgaggag     3360

gaatttgtag aagggatata caaagtggaa atagacacca aatcttactg gaaggcactt     3420

ggcatctccc cattccatga gcatgcagag gtgagtatac agaccttcga gggttgtttt     3480

ggttttggtt tttgcttttg gcattccagg aaatgcacag ttttactcag tgtaccacag     3540

aaatgtccta aggaaggtga tgaatgacca aaggttccct ttcctattat acaagaaaaa     3600

attcacaaca ctctgagaag caaatttctt tttgactttg atgaaaatcc acttagtaac     3660

atgacttgaa cttacatgaa actactcata gtctattcat tccactttat atgaatattg     3720

atgtatctgc tgttgaaata atagtttatg aggcagccct ccagacccca cgtagagtgt     3780

atgtaacaag agatgcacca ttttatttct cgaaaacccg taacattctt cattccaaaa     3840

cacatctggc ttctcggagg tctggacaag tgattcttgg caacacatac ctatagagac     3900

aataaaatca aagtaataat ggcaacacaa tagataacat ttaccaagca tacaccatgt     3960

ggcagacaca attataagtg ttttccatat ttaacctact taatcctcag gaataagcca     4020

ctgaggtcag tcctattatt atccccatct tatagatgaa gaaaatgagg caccaggaag     4080

tcaaataact tgtcaaaggt cacaagacta ggaaatacac aagtagaaat gtttacaatt     4140

aaggcccagg ctgggtttgc cctcagttct gctatgcctc gcattatgcc ccaggaaact     4200

ttttcccttg tgaaagccaa gcttaaaaaa agaaaagcca catttgtaac gtgctctgtt     4260

cccctgccta tggtgaggat cttcaaacag ttatacatgg acccagtccc cctgccttct     4320

ccttaatttc ttaagtcatt tgaaacagat ggctgtcatg gaaatagaat ccagacatgt     4380

tggtcagagt taaagatcaa ctaattccat caaaaatagc tcggcatgaa agggaactat     4440

tctctggctt agtcatggat gagactttca attgctataa agtggttcct ttattagaca     4500

atgttaccag ggaaacaaca ggggtttgtt tgacttctgg ggcccacaag tcaacaagag     4560

agccccatct accaaggagc atgtccctga ctacccctca gccagcagca agacatggac     4620

cccagtcagg gcaggagcag ggtttcggcg gcgcccagca caagacattg cccctagagt     4680

ctcagcccct accctcgagt aatagatctg cctacctgag actgttgttt gcccaagagc     4740

tgggtctcag cctgatggga accatataaa aaggttcact gacatactgc ccacatgttg     4800

ttctctttca ttagatctta gcttccttgt ctgctcttca ttcttgcagt attcattcaa     4860

caaacattaa aaaaaaaaaa aagcattcta tgtgtggaac actctgctag atgctgtgga     4920

tttagaaatg aaaatacatc ccgacccttg gaatggaagg gaaaggactg aagtaagaca     4980

gattaagcag gaccgtcagc ccagcttgaa gcccagataa atacggagaa caagagagag     5040

cgagtagtga gagatgagtc ccaatgcctc actttggtga cgggtgcgtg gtgggcttca     5100

tgcagcttct tctgataaat gcctccttca gaactggtca actctacctt ggccagtgac     5160

ccaggtggtc atagtagatt taccaaggga aaatggaaac ttttattagg agctcttagg     5220

cctcttcact tcatggattt ttttttcctt tttttttgag atggagtttt gccctgtcac     5280

ccaggctgga atgcagtggt gcaatctcag ctcactgcaa cctccgcctc ccaggttcaa     5340

gcaattctcc tgcctcagcc tcccgagtag ctgggactac aggtgtgcgc caccacacca     5400

ggctaatttt tgtatttttt gtaaagacag gttttcacca cgttggccag gctggtctga     5460

actccagacc tcaggtgatt cacctgtctc agcctcccaa agtgctggga ttacaggtgt     5520

gagccaccgt gcccggctac ttcatggatt tttgattaca gattatgcct cttacaattt     5580

ttaagaagaa tcaagtgggc tgaaggtcaa tgtcaccata agacaaaaga catttttatt     5640

agttgattct agggaattgg ccttaagggg agccctttct tcctaagaga ttcttaggtg     5700

attctcactt cctcttgccc cagtattatt tttgtttttg gtatggctca ctcagatcct     5760

tttttcctcc tatccctaag taatccgggt ttctttttcc catatttaga acaaaatgta     5820

tttatgcaga gtgtgtccaa acctcaaccc aaggcctgta tacaaaataa atcaaattaa     5880

acacatcttt actgtcttct acctctttcc tgacctcaat atatcccaac ttgcctcact     5940

ctgagaacca aggctgtccc agcacctgag tcgcagatat tctactgatt tgacagaact     6000

gtgtgactat ctggaacagc attttgatcc acaatttgcc cagttacaaa gcttaaatga     6060

gctctagtgc atgcatatat atttcaaaat tccaccatga tcttccacac tctgtattgt     6120

aaatagagcc ctgtaatgct tttacttcgt atttcattgc ttgttataca taaaaatata     6180

cttttcttct tcatgttaga aaatgcaaag aataggaggg tgggggaatc tctgggcttg     6240

gagacaggag acttgccttc ctactatggt tccatcagaa tgtagactgg gacaatacaa     6300

taattcaagt ctggtttgct catctgtaaa ttgggaagaa tgtttccagc tccagaatgc     6360

taaatctcta agtctgtggt tggcagccac tattgcagca gctcttcaat gactcaatgc     6420

agttttgcat tctccctacc ttttttttct aaaaccaata aaatagatac agcctttagg     6480

ctttctggga tttcccttag tcaagctagg gtcatcctga ctttcggcgt gaatttgcaa     6540

aacaagacct gactctgtac tcctgctcta aggactgtgc atggttccaa aggcttagct     6600

tgccagcata tttgagcttt ttccttctgt tcaaactgtt ccaaaatata aaagaataaa     6660

attaattaag ttggcactgg acttccggtg gtcagtcatg tgtgtcatct gtcacgtttt     6720

tcgggctctg gtggaaatgg atctgtctgt cttctctcat aggtggtatt cacagccaac     6780

gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc ctattccacc     6840

acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga cctgaaggac     6900

gagggatggg atttcatgta accaagagta ttccattttt actaaagcag tgttttcacc     6960

tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga aaggcacttt     7020

tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa aaaaagagaa     7080

tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa cgctaggaga     7140

gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct gcagccatta     7200

aaaagacaca ttctgtaaat gagagagcct tattttcctg taaccttcag caaatagcaa     7260

aagacacatt ccaagggccc acttctttac tgtgggcact cgagataact tcgtataatg     7320

tatgctatac gaagttatat gcatgccagt agcagcaccc acgtccacct tctgtctagt     7380

aatgtccaac acctccctca gtccaaacac tgctctgcat ccatgtggct cccatttata     7440

cctgaagcac ttgatggggc ctcaatgttt tactagagcc cacccccctg caactctgag     7500

accctctgga tttgtctgtc agtgcctcac tggggcgttg gataatttct taaaaggtca     7560

agttccctca gcagcattct ctgagcagtc tgaagatgtg tgcttttcac agttcaaatc     7620

catgtggctg tttcacccac ctgcctggcc ttgggttatc tatcaggacc tagcctagaa     7680

gcaggtgtgt ggcacttaac acctaagctg agtgactaac tgaacactca agtggatgcc     7740

atctttgtca cttcttgact gtgacacaag caactcctga tgccaaagcc ctgcccaccc     7800

ctctcatgcc catatttgga catggtacag gtcctcactg gccatggtct gtgaggtcct     7860

ggtcctcttt gacttcataa ttcctagggg ccactagtat ctataagagg aagagggtgc     7920

tggctcccag gccacagccc acaaaattcc acctgctcac aggttggctg gctcgaccca     7980

ggtggtgtcc cctgctctga gccagctccc ggccaagcca gcaccatggg aacccccaag     8040

aagaagagga aggtgcgtac cgatttaaat tccaatttac tgaccgtaca ccaaaatttg     8100

cctgcattac cggtcgatgc aacgagtgat gaggttcgca agaacctgat ggacatgttc     8160

agggatcgcc aggcgttttc tgagcatacc tggaaaatgc ttctgtccgt ttgccggtcg     8220

tgggcggcat ggtgcaagtt gaataaccgg aaatggtttc ccgcagaacc tgaagatgtt     8280

cgcgattatc ttctatatct tcaggcgcgc ggtctggcag taaaaactat ccagcaacat     8340

ttgggccagc taaacatgct tcatcgtcgg tccgggctgc cacgaccaag tgacagcaat     8400

gctgtttcac tggttatgcg gcggatccga aaagaaaacg ttgatgccgg tgaacgtgca     8460

aaacaggtaa atataaaatt tttaagtgta taatgatgtt aaactactga ttctaattgt     8520

ttgtgtattt taggctctag cgttcgaacg cactgatttc gaccaggttc gttcactcat     8580

ggaaaatagc gatcgctgcc aggatatacg taatctggca tttctgggga ttgcttataa     8640

caccctgtta cgtatagccg aaattgccag gatcagggtt aaagatatct cacgtactga     8700

cggtgggaga atgttaatcc atattggcag aacgaaaacg ctggttagca ccgcaggtgt     8760

agagaaggca cttagcctgg gggtaactaa actggtcgag cgatggattt ccgtctctgg     8820

tgtagctgat gatccgaata actacctgtt ttgccgggtc agaaaaaatg gtgttgccgc     8880

gccatctgcc accagccagc tatcaactcg cgccctggaa gggatttttg aagcaactca     8940

tcgattgatt tacggcgcta aggatgactc tggtcagaga tacctggcct ggtctggaca     9000

cagtgcccgt gtcggagccg cgcgagatat ggcccgcgct ggagtttcaa taccggagat     9060

catgcaagct ggtggctgga ccaatgtaaa tattgtcatg aactatatcc gtaacctgga     9120

tagtgaaaca ggggcaatgg tgcgcctgct ggaagatggc gattaggcgg ccggccgcta     9180

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     9240

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     9300

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     9360

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcccccgg     9420

ctagagttta aacactagaa ctagtggatc ccccgggatc atggcctccg cgccgggttt     9480

tggcgcctcc cgcgggcgcc cccctcctca cggcgagcgc tgccacgtca gacgaagggc     9540

gcagcgagcg tcctgatcct tccgcccgga cgctcaggac agcggcccgc tgctcataag     9600

actcggcctt agaaccccag tatcagcaga aggacatttt aggacgggac ttgggtgact     9660

ctagggcact ggttttcttt ccagagagcg gaacaggcga ggaaaagtag tcccttctcg     9720

gcgattctgc ggagggatct ccgtggggcg gtgaacgccg atgattatat aaggacgcgc     9780

cgggtgtggc acagctagtt ccgtcgcagc cgggatttgg gtcgcggttc ttgtttgtgg     9840

atcgctgtga tcgtcacttg gtgagtagcg ggctgctggg ctggccgggg ctttcgtggc     9900

cgccgggccg ctcggtggga cggaagcgtg tggagagacc gccaagggct gtagtctggg     9960

tccgcgagca aggttgccct gaactggggg ttggggggag cgcagcaaaa tggcggctgt    10020

tcccgagtct tgaatggaag acgcttgtga ggcgggctgt gaggtcgttg aaacaaggtg    10080

gggggcatgg tgggcggcaa gaacccaagg tcttgaggcc ttcgctaatg cgggaaagct    10140

cttattcggg tgagatgggc tggggcacca tctggggacc ctgacgtgaa gtttgtcact    10200

gactggagaa ctcggtttgt cgtctgttgc gggggcggca gttatggcgg tgccgttggg    10260

cagtgcaccc gtacctttgg gagcgcgcgc cctcgtcgtg tcgtgacgtc acccgttctg    10320

ttggcttata atgcagggtg gggccacctg ccggtaggtg tgcggtaggc ttttctccgt    10380

cgcaggacgc agggttcggg cctagggtag gctctcctga atcgacaggc gccggacctc    10440

tggtgagggg agggataagt gaggcgtcag tttctttggt cggttttatg tacctatctt    10500

cttaagtagc tgaagctccg gttttgaact atgcgctcgg ggttggcgag tgtgttttgt    10560

gaagtttttt aggcaccttt tgaaatgtaa tcatttgggt caatatgtaa ttttcagtgt    10620

tagactagta aattgtccgc taaattctgg ccgtttttgg cttttttgtt agacgtgttg    10680

acaattaatc atcggcatag tatatcggca tagtataata cgacaaggtg aggaactaaa    10740

ccatgaccga gtacaagccc acggtgcgcc tcgccacccg cgacgacgtc cccagggccg    10800

tacgcaccct cgccgccgcg ttcgccgact accccgccac gcgccacacc gtcgatccgg    10860

accgccacat cgagcgggtc accgagctgc aagaactctt cctcacgcgc gtcgggctcg    10920

acatcggcaa ggtgtgggtc gcggacgacg gcgccgcggt ggcggtctgg accacgccgg    10980

agagcgtcga agcgggggcg gtgttcgccg agatcggccc gcgcatggcc gagttgagcg    11040

gttcccggct ggccgcgcag caacagatgg aaggcctcct ggcgccgcac cggcccaagg    11100

agcccgcgtg gttcctggcc accgtcggcg tctcgcccga ccaccagggc aagggtctgg    11160

gcagcgccgt cgtgctcccc ggagtggagg cggccgagcg cgccggggtg cccgccttcc    11220

tggagacctc cgcgccccgc aacctcccct tctacgagcg gctcggcttc accgtcaccg    11280

ccgacgtcga ggtgcccgaa ggaccgcgca cctggtgcat gacccgcaag cccggtgcct    11340

gacgcccgcc ccacgacccg cagcgcccga ccgaaaggag cgcacgaccc catgcatcga    11400

tgatctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt    11460

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa    11520

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg    11580

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg    11640

gtgggctcta tggcttctga ggcggcctag ataacttcgt ataatgtatg ctatacgaag    11700

ttatgctagg taactataac ggtcctaagg tagcgagcta gcgagactca gcccaggagg    11760

accaggatct tgccaaagca gtagcatccc atttgtacca aaacagtgtt cttgctctat    11820

aaaccgtgtt agcagctcag ga                                             11842


<210>  23
<211>  7394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (98)..(7216)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (7217)..(7294)
<223>  Cassette Sequence

<220>
<221>  misc_feature
<222>  (7295)..(7394)
<223>  Mouse Sequence

<400>  23
agcttggcag ggatcagcag cctgggttgg aaggaggggg tataaaagcc ccttcaccag       60

gagaagccgt cacacagatc cacaagctcc tgacaggatg gcttctcatc gtctgctcct      120

cctctgcctt gctggactgg tatttgtgtc tgaggctggc cctacggtga gtgtttctgt      180

gacatcccat tcctacattt aagattcacg ctaaatgaag tagaagtgac tccttccagc      240

tttgccaacc agcttttatt actagggcaa gggtacccag catctatttt taatataatt      300

aattcaaact tcaaaaagaa tgaagttcca ctgagcttac tgagctggga cttgaactct      360

gagcattcta cctcattgct ttggtgcatt aggtttgtaa tatctggtac ctctgtttcc      420

tcagatagat gatagaaata aagatatgat attaaggaag ctgttaatac tgaattttca      480

gaaaagtatc cctccataaa atgtatttgg gggacaaact gcaggagatt atattctggc      540

cctatagtta ttcaaaacgt atttattgat taatctttaa aaggcttagt gaacaatatt      600

ctagtcagat atctaattct taaatcctct agaagaatta actaatacta taaaatgggt      660

ctggatgtag ttctgacatt attttataac aactggtaag agggagtgac tatagcaaca      720

actaaaatga tctcaggaaa acctgtttgg ccctatgtat ggtacattac atcttttcag      780

taattccact caaatggaga cttttaacaa agcaactgtt ctcaggggac ctattttctc      840

ccttaaaatt cattatacac atccctggtt gatagcagtg tgtctggagg cagaaaccat      900

tcttgctttg gaaacaatta cgtctgtgtt atactgagta gggaagctca ttaattgtcg      960

acacttacgt tcctgataat gggatcagtg tgtaattctt gtttcgctcc agatttctaa     1020

taccacaaag aataaatcct ttcactctga tcaattttgt taacttctca cgtgtcttct     1080

ctacacccag ggcaccggtg aatccaagtg tcctctgatg gtcaaagttc tagatgctgt     1140

ccgaggcagt cctgccatca atgtggccat gcatgtgttc agaaaggctg ctgatgacac     1200

ctgggagcca tttgcctctg ggtaagttgc caaagaaccc tcccacagga cttggtttta     1260

tcttcccgtt tgcccctcac ttggtagaga gaggctcaca tcatctgcta aagaatttac     1320

aagtagattg aaaaacgtag gcagaggtca agtatgccct ctgaaggatg ccctcttttt     1380

gttttgctta gctaggaagt gaccaggaac ctgagcatca tttaggggca gacagtagag     1440

aaaagaagga atcagaactc ctctcctcta gctgtggttt gcaacccttt tgggtcacag     1500

aacactttat gtaggtgatg aaaagtaaac attctatgcc cagaaaaaat gcacagatac     1560

acacacatac aaaatcatat atgtgatttt aggagtttca cagattccct ggtgtccctg     1620

ggtaacacca aagctaagtg tccttgtctt agaattttag gaaaaggtat aatgtgtatt     1680

aacccattaa caaaaggaaa ggaattcaga aatattatta accaggcatc tgtctgtagt     1740

taatatggat cacccaaaac ccaaggcttt tgcctaatga acactttggg gcacctactg     1800

tgtgcaaggc tgggggctgt caagctcagt taaaaaaaaa aagatagaag agatggatcc     1860

atgaggcaaa gtacagcccc aggctaatcc cacgatcacc cgacttcatg tccaagagtg     1920

gcttctcacc ttcattagcc agttcacaat tttcatggag tttttctacc tgcactagca     1980

aaaacttcaa ggaaaataca tattaataaa tctaagcaaa gtgaccagaa gacagagcaa     2040

tcaggagacc ctttgcatcc agcagaagag gaactgctaa gtatttacat ctccacagag     2100

aagaatttct gttgggtttt aattgaaccc caagaaccac atgattcttc aaccattatt     2160

gggaagatca ttttcttagg tctggtttta actggctttt tatttgggaa ttcatttatg     2220

tttatataaa atgccaagca taacatgaaa agtggttaca ggactattct aagggagaga     2280

cagaatggac accaaaaata ttccaatgtt cttgtgaatc ttttccttgc accaggacaa     2340

aaaaaaaaag aagtgaaaag aagaaaggag gaggggcata atcagagtca gtaaagacaa     2400

ctgctatttt tatctatcgt agctgttgca gtcaaatggg aagcaatttc caacattcaa     2460

ctatggagct ggtacttaca tggaaataga agttgcctag tgtttgttgc tggcaaagag     2520

ttatcagaga ggttaaatat ataaaaggga aaagagtcag atacaggttc ttcttcctac     2580

tttaggtttt ccactgtgtg tgcaaatgat actccctggt ggtgtgcaga tgcctcaaag     2640

ctatcctcac accacaaggg agaggagcga gatcctgctg tcctggagaa gtgcagagtt     2700

agaacagctg tggccacttg catccaatca tcaatcttga atcacaggga ctctttctta     2760

agtaaacatt atacctggcc gggcacggtg gctcacgcct gtaatcccag cactttggga     2820

tgccaaagtg ggcatatcat ctgaggtcag gagttcaaga ccagcctggc caacatggca     2880

aaactccgtc tttatgaaaa atacaaaaat tagccaggca tggtggcagg cgcctgtaat     2940

cccagctaat tgggaggctg aggctggaga atcccttgaa tctaggaggc agaggttgca     3000

gtgagctgag atcgtgccat tgcactccag cctgggtgac aagagtaaaa ctctgtctca     3060

aaaaaaaaaa attataccta cattctcttc ttatcagaga aaaaaatcta cagtgagctt     3120

ttcaaaaagt ttttacaaac tttttgccat ttaatttcag ttaggagttt tccctacttc     3180

tgacttagtt gaggggaaat gttcataaca tgtttataac atgtttatgt gtgttagttg     3240

gtgggggtgt attactttgc catgccattt gtttcctcca tgcgtaactt aatccagact     3300

ttcacacctt ataggaaaac cagtgagtct ggagagctgc atgggctcac aactgaggag     3360

gaatttgtag aagggatata caaagtggaa atagacacca aatcttactg gaaggcactt     3420

ggcatctccc cattccatga gcatgcagag gtgagtatac agaccttcga gggttgtttt     3480

ggttttggtt tttgcttttg gcattccagg aaatgcacag ttttactcag tgtaccacag     3540

aaatgtccta aggaaggtga tgaatgacca aaggttccct ttcctattat acaagaaaaa     3600

attcacaaca ctctgagaag caaatttctt tttgactttg atgaaaatcc acttagtaac     3660

atgacttgaa cttacatgaa actactcata gtctattcat tccactttat atgaatattg     3720

atgtatctgc tgttgaaata atagtttatg aggcagccct ccagacccca cgtagagtgt     3780

atgtaacaag agatgcacca ttttatttct cgaaaacccg taacattctt cattccaaaa     3840

cacatctggc ttctcggagg tctggacaag tgattcttgg caacacatac ctatagagac     3900

aataaaatca aagtaataat ggcaacacaa tagataacat ttaccaagca tacaccatgt     3960

ggcagacaca attataagtg ttttccatat ttaacctact taatcctcag gaataagcca     4020

ctgaggtcag tcctattatt atccccatct tatagatgaa gaaaatgagg caccaggaag     4080

tcaaataact tgtcaaaggt cacaagacta ggaaatacac aagtagaaat gtttacaatt     4140

aaggcccagg ctgggtttgc cctcagttct gctatgcctc gcattatgcc ccaggaaact     4200

ttttcccttg tgaaagccaa gcttaaaaaa agaaaagcca catttgtaac gtgctctgtt     4260

cccctgccta tggtgaggat cttcaaacag ttatacatgg acccagtccc cctgccttct     4320

ccttaatttc ttaagtcatt tgaaacagat ggctgtcatg gaaatagaat ccagacatgt     4380

tggtcagagt taaagatcaa ctaattccat caaaaatagc tcggcatgaa agggaactat     4440

tctctggctt agtcatggat gagactttca attgctataa agtggttcct ttattagaca     4500

atgttaccag ggaaacaaca ggggtttgtt tgacttctgg ggcccacaag tcaacaagag     4560

agccccatct accaaggagc atgtccctga ctacccctca gccagcagca agacatggac     4620

cccagtcagg gcaggagcag ggtttcggcg gcgcccagca caagacattg cccctagagt     4680

ctcagcccct accctcgagt aatagatctg cctacctgag actgttgttt gcccaagagc     4740

tgggtctcag cctgatggga accatataaa aaggttcact gacatactgc ccacatgttg     4800

ttctctttca ttagatctta gcttccttgt ctgctcttca ttcttgcagt attcattcaa     4860

caaacattaa aaaaaaaaaa aagcattcta tgtgtggaac actctgctag atgctgtgga     4920

tttagaaatg aaaatacatc ccgacccttg gaatggaagg gaaaggactg aagtaagaca     4980

gattaagcag gaccgtcagc ccagcttgaa gcccagataa atacggagaa caagagagag     5040

cgagtagtga gagatgagtc ccaatgcctc actttggtga cgggtgcgtg gtgggcttca     5100

tgcagcttct tctgataaat gcctccttca gaactggtca actctacctt ggccagtgac     5160

ccaggtggtc atagtagatt taccaaggga aaatggaaac ttttattagg agctcttagg     5220

cctcttcact tcatggattt ttttttcctt tttttttgag atggagtttt gccctgtcac     5280

ccaggctgga atgcagtggt gcaatctcag ctcactgcaa cctccgcctc ccaggttcaa     5340

gcaattctcc tgcctcagcc tcccgagtag ctgggactac aggtgtgcgc caccacacca     5400

ggctaatttt tgtatttttt gtaaagacag gttttcacca cgttggccag gctggtctga     5460

actccagacc tcaggtgatt cacctgtctc agcctcccaa agtgctggga ttacaggtgt     5520

gagccaccgt gcccggctac ttcatggatt tttgattaca gattatgcct cttacaattt     5580

ttaagaagaa tcaagtgggc tgaaggtcaa tgtcaccata agacaaaaga catttttatt     5640

agttgattct agggaattgg ccttaagggg agccctttct tcctaagaga ttcttaggtg     5700

attctcactt cctcttgccc cagtattatt tttgtttttg gtatggctca ctcagatcct     5760

tttttcctcc tatccctaag taatccgggt ttctttttcc catatttaga acaaaatgta     5820

tttatgcaga gtgtgtccaa acctcaaccc aaggcctgta tacaaaataa atcaaattaa     5880

acacatcttt actgtcttct acctctttcc tgacctcaat atatcccaac ttgcctcact     5940

ctgagaacca aggctgtccc agcacctgag tcgcagatat tctactgatt tgacagaact     6000

gtgtgactat ctggaacagc attttgatcc acaatttgcc cagttacaaa gcttaaatga     6060

gctctagtgc atgcatatat atttcaaaat tccaccatga tcttccacac tctgtattgt     6120

aaatagagcc ctgtaatgct tttacttcgt atttcattgc ttgttataca taaaaatata     6180

cttttcttct tcatgttaga aaatgcaaag aataggaggg tgggggaatc tctgggcttg     6240

gagacaggag acttgccttc ctactatggt tccatcagaa tgtagactgg gacaatacaa     6300

taattcaagt ctggtttgct catctgtaaa ttgggaagaa tgtttccagc tccagaatgc     6360

taaatctcta agtctgtggt tggcagccac tattgcagca gctcttcaat gactcaatgc     6420

agttttgcat tctccctacc ttttttttct aaaaccaata aaatagatac agcctttagg     6480

ctttctggga tttcccttag tcaagctagg gtcatcctga ctttcggcgt gaatttgcaa     6540

aacaagacct gactctgtac tcctgctcta aggactgtgc atggttccaa aggcttagct     6600

tgccagcata tttgagcttt ttccttctgt tcaaactgtt ccaaaatata aaagaataaa     6660

attaattaag ttggcactgg acttccggtg gtcagtcatg tgtgtcatct gtcacgtttt     6720

tcgggctctg gtggaaatgg atctgtctgt cttctctcat aggtggtatt cacagccaac     6780

gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc ctattccacc     6840

acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga cctgaaggac     6900

gagggatggg atttcatgta accaagagta ttccattttt actaaagcag tgttttcacc     6960

tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga aaggcacttt     7020

tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa aaaaagagaa     7080

tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa cgctaggaga     7140

gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct gcagccatta     7200

aaaagacaca ttctgtctcg agataacttc gtataatgta tgctatacga agttatgcta     7260

ggtaactata acggtcctaa ggtagcgagc tagcgagact cagcccagga ggaccaggat     7320

cttgccaaag cagtagcatc ccatttgtac caaaacagtg ttcttgctct ataaaccgtg     7380

ttagcagctc agga                                                       7394


<210>  24
<211>  7119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct       60

ggccctacgg tgagtgtttc tgtgacatcc cattcctaca tttaagattc acgctaaatg      120

aagtagaagt gactccttcc agctttgcca accagctttt attactaggg caagggtacc      180

cagcatctat ttttaatata attaattcaa acttcaaaaa gaatgaagtt ccactgagct      240

tactgagctg ggacttgaac tctgagcatt ctacctcatt gctttggtgc attaggtttg      300

taatatctgg tacctctgtt tcctcagata gatgatagaa ataaagatat gatattaagg      360

aagctgttaa tactgaattt tcagaaaagt atccctccat aaaatgtatt tgggggacaa      420

actgcaggag attatattct ggccctatag ttattcaaaa cgtatttatt gattaatctt      480

taaaaggctt agtgaacaat attctagtca gatatctaat tcttaaatcc tctagaagaa      540

ttaactaata ctataaaatg ggtctggatg tagttctgac attattttat aacaactggt      600

aagagggagt gactatagca acaactaaaa tgatctcagg aaaacctgtt tggccctatg      660

tatggtacat tacatctttt cagtaattcc actcaaatgg agacttttaa caaagcaact      720

gttctcaggg gacctatttt ctcccttaaa attcattata cacatccctg gttgatagca      780

gtgtgtctgg aggcagaaac cattcttgct ttggaaacaa ttacgtctgt gttatactga      840

gtagggaagc tcattaattg tcgacactta cgttcctgat aatgggatca gtgtgtaatt      900

cttgtttcgc tccagatttc taataccaca aagaataaat cctttcactc tgatcaattt      960

tgttaacttc tcacgtgtct tctctacacc cagggcaccg gtgaatccaa gtgtcctctg     1020

atggtcaaag ttctagatgc tgtccgaggc agtcctgcca tcaatgtggc catgcatgtg     1080

ttcagaaagg ctgctgatga cacctgggag ccatttgcct ctgggtaagt tgccaaagaa     1140

ccctcccaca ggacttggtt ttatcttccc gtttgcccct cacttggtag agagaggctc     1200

acatcatctg ctaaagaatt tacaagtaga ttgaaaaacg taggcagagg tcaagtatgc     1260

cctctgaagg atgccctctt tttgttttgc ttagctagga agtgaccagg aacctgagca     1320

tcatttaggg gcagacagta gagaaaagaa ggaatcagaa ctcctctcct ctagctgtgg     1380

tttgcaaccc ttttgggtca cagaacactt tatgtaggtg atgaaaagta aacattctat     1440

gcccagaaaa aatgcacaga tacacacaca tacaaaatca tatatgtgat tttaggagtt     1500

tcacagattc cctggtgtcc ctgggtaaca ccaaagctaa gtgtccttgt cttagaattt     1560

taggaaaagg tataatgtgt attaacccat taacaaaagg aaaggaattc agaaatatta     1620

ttaaccaggc atctgtctgt agttaatatg gatcacccaa aacccaaggc ttttgcctaa     1680

tgaacacttt ggggcaccta ctgtgtgcaa ggctgggggc tgtcaagctc agttaaaaaa     1740

aaaaagatag aagagatgga tccatgaggc aaagtacagc cccaggctaa tcccacgatc     1800

acccgacttc atgtccaaga gtggcttctc accttcatta gccagttcac aattttcatg     1860

gagtttttct acctgcacta gcaaaaactt caaggaaaat acatattaat aaatctaagc     1920

aaagtgacca gaagacagag caatcaggag accctttgca tccagcagaa gaggaactgc     1980

taagtattta catctccaca gagaagaatt tctgttgggt tttaattgaa ccccaagaac     2040

cacatgattc ttcaaccatt attgggaaga tcattttctt aggtctggtt ttaactggct     2100

ttttatttgg gaattcattt atgtttatat aaaatgccaa gcataacatg aaaagtggtt     2160

acaggactat tctaagggag agacagaatg gacaccaaaa atattccaat gttcttgtga     2220

atcttttcct tgcaccagga caaaaaaaaa aagaagtgaa aagaagaaag gaggaggggc     2280

ataatcagag tcagtaaaga caactgctat ttttatctat cgtagctgtt gcagtcaaat     2340

gggaagcaat ttccaacatt caactatgga gctggtactt acatggaaat agaagttgcc     2400

tagtgtttgt tgctggcaaa gagttatcag agaggttaaa tatataaaag ggaaaagagt     2460

cagatacagg ttcttcttcc tactttaggt tttccactgt gtgtgcaaat gatactccct     2520

ggtggtgtgc agatgcctca aagctatcct cacaccacaa gggagaggag cgagatcctg     2580

ctgtcctgga gaagtgcaga gttagaacag ctgtggccac ttgcatccaa tcatcaatct     2640

tgaatcacag ggactctttc ttaagtaaac attatacctg gccgggcacg gtggctcacg     2700

cctgtaatcc cagcactttg ggatgccaaa gtgggcatat catctgaggt caggagttca     2760

agaccagcct ggccaacatg gcaaaactcc gtctttatga aaaatacaaa aattagccag     2820

gcatggtggc aggcgcctgt aatcccagct aattgggagg ctgaggctgg agaatccctt     2880

gaatctagga ggcagaggtt gcagtgagct gagatcgtgc cattgcactc cagcctgggt     2940

gacaagagta aaactctgtc tcaaaaaaaa aaaattatac ctacattctc ttcttatcag     3000

agaaaaaaat ctacagtgag cttttcaaaa agtttttaca aactttttgc catttaattt     3060

cagttaggag ttttccctac ttctgactta gttgagggga aatgttcata acatgtttat     3120

aacatgttta tgtgtgttag ttggtggggg tgtattactt tgccatgcca tttgtttcct     3180

ccatgcgtaa cttaatccag actttcacac cttataggaa aaccagtgag tctggagagc     3240

tgcatgggct cacaactgag gaggaatttg tagaagggat atacaaagtg gaaatagaca     3300

ccaaatctta ctggaaggca cttggcatct ccccattcca tgagcatgca gaggtgagta     3360

tacagacctt cgagggttgt tttggttttg gtttttgctt ttggcattcc aggaaatgca     3420

cagttttact cagtgtacca cagaaatgtc ctaaggaagg tgatgaatga ccaaaggttc     3480

cctttcctat tatacaagaa aaaattcaca acactctgag aagcaaattt ctttttgact     3540

ttgatgaaaa tccacttagt aacatgactt gaacttacat gaaactactc atagtctatt     3600

cattccactt tatatgaata ttgatgtatc tgctgttgaa ataatagttt atgaggcagc     3660

cctccagacc ccacgtagag tgtatgtaac aagagatgca ccattttatt tctcgaaaac     3720

ccgtaacatt cttcattcca aaacacatct ggcttctcgg aggtctggac aagtgattct     3780

tggcaacaca tacctataga gacaataaaa tcaaagtaat aatggcaaca caatagataa     3840

catttaccaa gcatacacca tgtggcagac acaattataa gtgttttcca tatttaacct     3900

acttaatcct caggaataag ccactgaggt cagtcctatt attatcccca tcttatagat     3960

gaagaaaatg aggcaccagg aagtcaaata acttgtcaaa ggtcacaaga ctaggaaata     4020

cacaagtaga aatgtttaca attaaggccc aggctgggtt tgccctcagt tctgctatgc     4080

ctcgcattat gccccaggaa actttttccc ttgtgaaagc caagcttaaa aaaagaaaag     4140

ccacatttgt aacgtgctct gttcccctgc ctatggtgag gatcttcaaa cagttataca     4200

tggacccagt ccccctgcct tctccttaat ttcttaagtc atttgaaaca gatggctgtc     4260

atggaaatag aatccagaca tgttggtcag agttaaagat caactaattc catcaaaaat     4320

agctcggcat gaaagggaac tattctctgg cttagtcatg gatgagactt tcaattgcta     4380

taaagtggtt cctttattag acaatgttac cagggaaaca acaggggttt gtttgacttc     4440

tggggcccac aagtcaacaa gagagcccca tctaccaagg agcatgtccc tgactacccc     4500

tcagccagca gcaagacatg gaccccagtc agggcaggag cagggtttcg gcggcgccca     4560

gcacaagaca ttgcccctag agtctcagcc cctaccctcg agtaatagat ctgcctacct     4620

gagactgttg tttgcccaag agctgggtct cagcctgatg ggaaccatat aaaaaggttc     4680

actgacatac tgcccacatg ttgttctctt tcattagatc ttagcttcct tgtctgctct     4740

tcattcttgc agtattcatt caacaaacat taaaaaaaaa aaaaagcatt ctatgtgtgg     4800

aacactctgc tagatgctgt ggatttagaa atgaaaatac atcccgaccc ttggaatgga     4860

agggaaagga ctgaagtaag acagattaag caggaccgtc agcccagctt gaagcccaga     4920

taaatacgga gaacaagaga gagcgagtag tgagagatga gtcccaatgc ctcactttgg     4980

tgacgggtgc gtggtgggct tcatgcagct tcttctgata aatgcctcct tcagaactgg     5040

tcaactctac cttggccagt gacccaggtg gtcatagtag atttaccaag ggaaaatgga     5100

aacttttatt aggagctctt aggcctcttc acttcatgga tttttttttc cttttttttt     5160

gagatggagt tttgccctgt cacccaggct ggaatgcagt ggtgcaatct cagctcactg     5220

caacctccgc ctcccaggtt caagcaattc tcctgcctca gcctcccgag tagctgggac     5280

tacaggtgtg cgccaccaca ccaggctaat ttttgtattt tttgtaaaga caggttttca     5340

ccacgttggc caggctggtc tgaactccag acctcaggtg attcacctgt ctcagcctcc     5400

caaagtgctg ggattacagg tgtgagccac cgtgcccggc tacttcatgg atttttgatt     5460

acagattatg cctcttacaa tttttaagaa gaatcaagtg ggctgaaggt caatgtcacc     5520

ataagacaaa agacattttt attagttgat tctagggaat tggccttaag gggagccctt     5580

tcttcctaag agattcttag gtgattctca cttcctcttg ccccagtatt atttttgttt     5640

ttggtatggc tcactcagat ccttttttcc tcctatccct aagtaatccg ggtttctttt     5700

tcccatattt agaacaaaat gtatttatgc agagtgtgtc caaacctcaa cccaaggcct     5760

gtatacaaaa taaatcaaat taaacacatc tttactgtct tctacctctt tcctgacctc     5820

aatatatccc aacttgcctc actctgagaa ccaaggctgt cccagcacct gagtcgcaga     5880

tattctactg atttgacaga actgtgtgac tatctggaac agcattttga tccacaattt     5940

gcccagttac aaagcttaaa tgagctctag tgcatgcata tatatttcaa aattccacca     6000

tgatcttcca cactctgtat tgtaaataga gccctgtaat gcttttactt cgtatttcat     6060

tgcttgttat acataaaaat atacttttct tcttcatgtt agaaaatgca aagaatagga     6120

gggtggggga atctctgggc ttggagacag gagacttgcc ttcctactat ggttccatca     6180

gaatgtagac tgggacaata caataattca agtctggttt gctcatctgt aaattgggaa     6240

gaatgtttcc agctccagaa tgctaaatct ctaagtctgt ggttggcagc cactattgca     6300

gcagctcttc aatgactcaa tgcagttttg cattctccct accttttttt tctaaaacca     6360

ataaaataga tacagccttt aggctttctg ggatttccct tagtcaagct agggtcatcc     6420

tgactttcgg cgtgaatttg caaaacaaga cctgactctg tactcctgct ctaaggactg     6480

tgcatggttc caaaggctta gcttgccagc atatttgagc tttttccttc tgttcaaact     6540

gttccaaaat ataaaagaat aaaattaatt aagttggcac tggacttccg gtggtcagtc     6600

atgtgtgtca tctgtcacgt ttttcgggct ctggtggaaa tggatctgtc tgtcttctct     6660

cataggtggt attcacagcc aacgactccg gcccccgccg ctacaccatt gccgccctgc     6720

tgagccccta ctcctattcc accacggctg tcgtcaccaa tcccaaggaa tgagggactt     6780

ctcctccagt ggacctgaag gacgagggat gggatttcat gtaaccaaga gtattccatt     6840

tttactaaag cagtgttttc acctcatatg ctatgttaga agtccaggca gagacaataa     6900

aacattcctg tgaaaggcac ttttcattcc actttaactt gattttttaa attcccttat     6960

tgtcccttcc aaaaaaaaga gaatcaaaat tttacaaaga atcaaaggaa ttctagaaag     7020

tatctgggca gaacgctagg agagatccaa atttccattg tcttgcaagc aaagcacgta     7080

ttaaatatga tctgcagcca ttaaaaagac acattctgt                            7119


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
cacagacaat cagacgtacc agta                                              24


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gggacatctc ggtttcctga ctt                                               23


<210>  27
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
tcatgtaatc tggcttcaga gtggga                                            26


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
ccagctttgc cagtttacga                                                   20


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
tccacactac tgaactccac aa                                                22


<210>  30
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
tgggaggcaa ttcttagttt caatgga                                           27


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
ttggacggtt gccctctt                                                     18


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
cggaacactc gctctacgaa a                                                 21


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
tcccaaaggt gtctgtctgc aca                                               23


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
gatggcttcc cttcgactct tc                                                22


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
gggccagctt cagacaca                                                     18


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ctcctttgcc tcgctggact gg                                                22


<210>  37
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cactgacatt tctcttgtct cctct                                             25


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
cccagggtgc tggagaatcc aa                                                22


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
cggacagcat ccaggactt                                                    19


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gggctcacca cagatgagaa g                                                 21


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
gccaagtgtc ttccagtacg at                                                22


<210>  42
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
agaaggagtg tacagagtag aactggaca                                         29


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
cactgttcgc cacaggtctt                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
gttccctttc ttgggttcag a                                                 21


<210>  45
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
tgtttgtggg tgtcagtgtt tctactc                                           27


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gctcagccca tactcctaca                                                   20


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gatgctactg ctttggcaag atc                                               23


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
caccacggct gtcgtcagca a                                                 21


<210>  49
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
gcccaggagg accaggat                                                     18


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
cctgagctgc taacacggtt                                                   20


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
cttgccaaag cagtagcatc cca                                               23


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
ggcaacttgc ttgaggaaga                                                   20


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
agctacagac catgcttagt gta                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
aggtcagaaa gcagagtgga cca                                               23


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
gcagcaaccc agcttcactt                                                   20


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
tgccagttta ggaggaatat gttc                                              24


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
cccaggcaat tcctaccttc cca                                               23


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
actgagctgg gacttgaac                                                    19


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
ctgaggaaac agaggtacca gatat                                             25


<210>  60
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
tctgagcatt ctacctcatt gctttggt                                          28


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
tgcctcactc tgagaacca                                                    19


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
agtcacacag ttctgtcaaa tcag                                              24


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
aggctgtccc agcacctgag tcg                                               23


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
cgcaacctcc ccttctacg                                                    19


<210>  65
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gtccttcggg cacctcg                                                      17


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
cggctcggct tcaccgtcac c                                                 21


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
ggccgtgcat gtgttcag                                                     18


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
tcctgtggga gggttctttg                                                   20


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
aaggctgctg atgacacctg gga                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
ggttcccatt tgctcttatt cgt                                               23


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
ccctctctct gagccctcta                                                   20


<210>  72
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
agattcagac acacacaact taccagc                                           27


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
cccacactgc agaaggaaac ttg                                               23


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
gctgcctaag tctttggagc t                                                 21


<210>  75
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
agacctgcaa ttctctaaga gctccaca                                          28


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
ggttcccatt tgctcttatt cgt                                               23


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
ccctctctct gagccctcta                                                   20


<210>  78
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
agattcagac acacacaact taccagc                                           27


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
ccagcttagc atcctgtgaa ca                                                22


<210>  80
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
gagaggagag acagctagtt ctaac                                             25


<210>  81
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
ttgtctgcag ctcctacctc tggg                                              24


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
ggcaacttgc ttgaggaaga                                                   20


<210>  83
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
agctacagac catgcttagt gta                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
aggtcagaaa gcagagtgga cca                                               23


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
tgtggagttc agtagtgtgg ag                                                22


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
gccctcttca tacaggaatc ac                                                22


<210>  87
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
ttgacatgtg tgggtgagag attttactg                                         29


<210>  88
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
cactgacatt tctcttgtct cctct                                             25


<210>  89
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
cggacagcat ccaggactt                                                    19


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
cccagggtgc tggagaatcc aa                                                22


<210>  91
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
ctgtccgagg cagtcctg                                                     18


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
gtgtcatcag cagcctttct g                                                 21


<210>  93
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
aatgtggccg tgcatg                                                       16


<210>  94
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
ctgtccgagg cagtcctg                                                     18


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
gtgtcatcag cagcctttct g                                                 21


<210>  96
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
atgtggccat gcatg                                                        15


<210>  97
<211>  1471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Pro Lys Lys  Lys Arg Lys Val Ala  Ala Ala Gly 
    1400                 1405                 1410             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1415                 1420                 1425             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1430                 1435                 1440             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Cys  Thr 
    1460                 1465                 1470     


<210>  98
<211>  1384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp 
    


<210>  99
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99

Ala Ala Ala Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu 
1               5                   10                  15      


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            20                  25                  30          


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        35                  40                  45              


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Cys Thr 
    50                  55                  60          


<210>  100
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Gly Gly Gly Ser 
1               


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Gly Gly Gly Gly Ser 
1               5   


<210>  102
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Gly Ser 
145                 150                 155                 160 


Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
                165                 170                 175     


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            180                 185                 190         


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        195                 200                 205             


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    210                 215                 220                 


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
225                 230                 235                 240 


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                245                 250                 255     


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            260                 265                 270         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        275                 280                 285             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    290                 295                 300                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
305                 310                 315                 320 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                325                 330                 335     


Ser Gln Ile Ser Ser Ser Gly Gln Gly Gly Gly Gly Ser Gly Phe Ser 
            340                 345                 350         


Val Asp Thr Ser Ala Leu Leu Asp Leu Phe Ser Pro Ser Val Thr Val 
        355                 360                 365             


Pro Asp Met Ser Leu Pro Asp Leu Asp Ser Ser Leu Ala Ser Ile Gln 
    370                 375                 380                 


Glu Leu Leu Ser Pro Gln Glu Pro Pro Arg Pro Pro Glu Ala Glu Asn 
385                 390                 395                 400 


Ser Ser Pro Asp Ser Gly Lys Gln Leu Val His Tyr Thr Ala Gln Pro 
                405                 410                 415     


Leu Phe Leu Leu Asp Pro Gly Ser Val Asp Thr Gly Ser Asn Asp Leu 
            420                 425                 430         


Pro Val Leu Phe Glu Leu Gly Glu Gly Ser Tyr Phe Ser Glu Gly Asp 
        435                 440                 445             


Gly Phe Ala Glu Asp Pro Thr Ile Ser Leu Leu Thr Gly Ser Glu Pro 
    450                 455                 460                 


Pro Lys Ala Lys Asp Pro Thr Val Ser 
465                 470             


<210>  103
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210>  104
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104

Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
1               5                   10                  15      


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            20                  25                  30          


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        35                  40                  45              


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    50                  55                  60                  


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
65                  70                  75                  80  


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                85                  90                  95      


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            100                 105                 110         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        115                 120                 125             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    130                 135                 140                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
145                 150                 155                 160 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                165                 170                 175     


Ser Gln Ile Ser Ser 
            180     


<210>  105
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105

Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp Leu Phe Ser Pro Ser 
1               5                   10                  15      


Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu Asp Ser Ser Leu Ala 
            20                  25                  30          


Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro Pro Arg Pro Pro Glu 
        35                  40                  45              


Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln Leu Val His Tyr Thr 
    50                  55                  60                  


Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser Val Asp Thr Gly Ser 
65                  70                  75                  80  


Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu Gly Ser Tyr Phe Ser 
                85                  90                  95      


Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile Ser Leu Leu Thr Gly 
            100                 105                 110         


Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val Ser 
        115                 120                 


<210>  106
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
ggccaacaug aggaucaccc augucugcag ggcc                                   34


<210>  107
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  108
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  109
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  110
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  111
<211>  4152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg ac                                                         4152


<210>  112
<211>  4414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggcg gccgctggat ccggacgggc tgacgcattg     4260

gacgattttg atctggatat gctgggaagt gacgccctcg atgattttga ccttgacatg     4320

cttggttcgg atgcccttga tgactttgac ctcgacatgc tcggcagtga cgcccttgat     4380

gatttcgacc tggacatgct gattaactgt acag                                 4414


<210>  113
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca       60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc      120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc      180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc      240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct      300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct      360

tccgccatcg ccgctaactc aggtatctac                                       390


<210>  114
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca       60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc      120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc      180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc      240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct      300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct      360

tccgccatcg ccgctaactc aggtatctac agcgctggag gaggtggaag cggaggagga      420

ggaagcggag gaggaggtag cggacctaag aaaaagagga aggtggcggc cgctggatcc      480

ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg      540

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc      600

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag      660

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac      720

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg      780

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc      840

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg      900

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga      960

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc     1020

tctagtgggc agggaggagg tggaagcggc ttcagcgtgg acaccagtgc cctgctggac     1080

ctgttcagcc cctcggtgac cgtgcccgac atgagcctgc ctgaccttga cagcagcctg     1140

gccagtatcc aagagctcct gtctccccag gagcccccca ggcctcccga ggcagagaac     1200

agcagcccgg attcagggaa gcagctggtg cactacacag cgcagccgct gttcctgctg     1260

gaccccggct ccgtggacac cgggagcaac gacctgccgg tgctgtttga gctgggagag     1320

ggctcctact tctccgaagg ggacggcttc gccgaggacc ccaccatctc cctgctgaca     1380

ggctcggagc ctcccaaagc caaggacccc actgtctcc                            1419


<210>  115
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115
gcggccgctg gatccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga       60

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt      120

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac      180

tgtacag                                                                187


<210>  116
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116
ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg       60

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc      120

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag      180

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac      240

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg      300

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc      360

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg      420

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga      480

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc      540

tct                                                                    543


<210>  117
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117
ggcttcagcg tggacaccag tgccctgctg gacctgttca gcccctcggt gaccgtgccc       60

gacatgagcc tgcctgacct tgacagcagc ctggccagta tccaagagct cctgtctccc      120

caggagcccc ccaggcctcc cgaggcagag aacagcagcc cggattcagg gaagcagctg      180

gtgcactaca cagcgcagcc gctgttcctg ctggaccccg gctccgtgga caccgggagc      240

aacgacctgc cggtgctgtt tgagctggga gagggctcct acttctccga aggggacggc      300

ttcgccgagg accccaccat ctccctgctg acaggctcgg agcctcccaa agccaaggac      360

cccactgtct cc                                                          372


<210>  118
<211>  9043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  First loxP site

<220>
<221>  misc_feature
<222>  (125)..(928)
<223>  Neomycin phosphotransferase

<220>
<221>  misc_feature
<222>  (937)..(2190)
<223>  Polyadenylation signal

<220>
<221>  misc_feature
<222>  (2218)..(2251)
<223>  Second loxP site

<220>
<221>  misc_feature
<222>  (2306)..(6457)
<223>  Codon-optimized dCas9

<220>
<221>  misc_feature
<222>  (2309)..(2356)
<223>  NLS

<220>
<221>  misc_feature
<222>  (6512)..(6532)
<223>  NLS

<220>
<221>  misc_feature
<222>  (6533)..(6719)
<223>  VP64

<220>
<221>  misc_feature
<222>  (6728 )..(6781)
<223>  T2A

<220>
<221>  misc_feature
<222>  (6782)..(7171)
<223>  MCP

<220>
<221>  misc_feature
<222>  (7226)..(7246)
<223>  NLS

<220>
<221>  misc_feature
<222>  (7262)..(7804)
<223>  p65

<220>
<221>  misc_feature
<222>  (7829)..(8200)
<223>  HSF1

<220>
<221>  misc_feature
<222>  (8224)..(8820)
<223>  Woodchuck hepatitis virus posttranscriptional regulatory element 
       (WPRE)

<400>  118
ataacttcgt ataatgtatg ctatacgaag ttattaggtc cctcgacctg caggaattgt       60

tgacaattaa tcatcggcat agtatatcgg catagtataa tacgacaagg tgaggaacta      120

aaccatggga tcggccattg aacaagatgg attgcacgca ggttctccgg ccgcttgggt      180

ggagaggcta ttcggctatg actgggcaca acagacaatc ggctgctctg atgccgccgt      240

gttccggctg tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc tgtccggtgc      300

cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga cgggcgttcc      360

ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg gactggctgc tattgggcga      420

agtgccgggg caggatctcc tgtcatctca ccttgctcct gccgagaaag tatccatcat      480

ggctgatgca atgcggcggc tgcatacgct tgatccggct acctgcccat tcgaccacca      540

agcgaaacat cgcatcgagc gagcacgtac tcggatggaa gccggtcttg tcgatcagga      600

tgatctggac gaagagcatc aggggctcgc gccagccgaa ctgttcgcca ggctcaaggc      660

gcgcatgccc gacggcgatg atctcgtcgt gacccatggc gatgcctgct tgccgaatat      720

catggtggaa aatggccgct tttctggatt catcgactgt ggccggctgg gtgtggcgga      780

ccgctatcag gacatagcgt tggctacccg tgatattgct gaagagcttg gcggcgaatg      840

ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc gattcgcagc gcatcgcctt      900

ctatcgcctt cttgacgagt tcttctgagg ggatccgctg taagtctgca gaaattgatg      960

atctattaaa caataaagat gtccactaaa atggaagttt ttcctgtcat actttgttaa     1020

gaagggtgag aacagagtac ctacattttg aatggaagga ttggagctac gggggtgggg     1080

gtggggtggg attagataaa tgcctgctct ttactgaagg ctctttacta ttgctttatg     1140

ataatgtttc atagttggat atcataattt aaacaagcaa aaccaaatta agggccagct     1200

cattcctccc actcatgatc tatagatcta tagatctctc gtgggatcat tgtttttctc     1260

ttgattccca ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt ttcatagcct     1320

gaagaacgag atcagcagcc tctgttccac atacacttca ttctcagtat tgttttgcca     1380

agttctaatt ccatcagaag cttgcagatc tgcgactcta gaggatctgc gactctagag     1440

gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca     1500

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc     1560

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     1620

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat     1680

ctgcgactct agaggatcat aatcagccat accacatttg tagaggtttt acttgcttta     1740

aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt     1800

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     1860

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct     1920

tatcatgtct ggatctgcga ctctagagga tcataatcag ccataccaca tttgtagagg     1980

ttttacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg     2040

caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     2100

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     2160

tcatcaatgt atcttatcat gtctggatcc ccatcaagct gatccggaac ccttaatata     2220

acttcgtata atgtatgcta tacgaagtta ttaggtccct cgacctgcag cccaagctag     2280

tgcccgggaa ttcgctaggg ccaccatgaa aaggccggcg gccacgaaaa aggccggcca     2340

ggcaaaaaag aaaaaggaca agaagtacag catcggcctg gccatcggca ccaactctgt     2400

gggctgggcc gtgatcaccg acgagtacaa ggtgcccagc aagaaattca aggtgctggg     2460

caacaccgac cggcacagca tcaagaagaa cctgatcgga gccctgctgt tcgacagcgg     2520

cgaaacagcc gaggccaccc ggctgaagag aaccgccaga agaagataca ccagacggaa     2580

gaaccggatc tgctatctgc aagagatctt cagcaacgag atggccaagg tggacgacag     2640

cttcttccac agactggaag agtccttcct ggtggaagag gataagaagc acgagcggca     2700

ccccatcttc ggcaacatcg tggacgaggt ggcctaccac gagaagtacc ccaccatcta     2760

ccacctgaga aagaaactgg tggacagcac cgacaaggcc gacctgcggc tgatctatct     2820

ggccctggcc cacatgatca agttccgggg ccacttcctg atcgagggcg acctgaaccc     2880

cgacaacagc gacgtggaca agctgttcat ccagctggtg cagacctaca accagctgtt     2940

cgaggaaaac cccatcaacg ccagcggcgt ggacgccaag gccatcctgt ctgccagact     3000

gagcaagagc agacggctgg aaaatctgat cgcccagctg cccggcgaga agaagaatgg     3060

cctgttcggc aacctgattg ccctgagcct gggcctgacc cccaacttca agagcaactt     3120

cgacctggcc gaggatgcca aactgcagct gagcaaggac acctacgacg acgacctgga     3180

caacctgctg gcccagatcg gcgaccagta cgccgacctg tttctggccg ccaagaacct     3240

gtccgacgcc atcctgctga gcgacatcct gagagtgaac accgagatca ccaaggcccc     3300

cctgagcgcc tctatgatca agagatacga cgagcaccac caggacctga ccctgctgaa     3360

agctctcgtg cggcagcagc tgcctgagaa gtacaaagag attttcttcg accagagcaa     3420

gaacggctac gccggctaca ttgacggcgg agccagccag gaagagttct acaagttcat     3480

caagcccatc ctggaaaaga tggacggcac cgaggaactg ctcgtgaagc tgaacagaga     3540

ggacctgctg cggaagcagc ggaccttcga caacggcagc atcccccacc agatccacct     3600

gggagagctg cacgccattc tgcggcggca ggaagatttt tacccattcc tgaaggacaa     3660

ccgggaaaag atcgagaaga tcctgacctt ccgcatcccc tactacgtgg gccctctggc     3720

caggggaaac agcagattcg cctggatgac cagaaagagc gaggaaacca tcaccccctg     3780

gaacttcgag gaagtggtgg acaagggcgc ttccgcccag agcttcatcg agcggatgac     3840

caacttcgat aagaacctgc ccaacgagaa ggtgctgccc aagcacagcc tgctgtacga     3900

gtacttcacc gtgtataacg agctgaccaa agtgaaatac gtgaccgagg gaatgagaaa     3960

gcccgccttc ctgagcggcg agcagaaaaa ggccatcgtg gacctgctgt tcaagaccaa     4020

ccggaaagtg accgtgaagc agctgaaaga ggactacttc aagaaaatcg agtgcttcga     4080

ctccgtggaa atctccggcg tggaagatcg gttcaacgcc tccctgggca cataccacga     4140

tctgctgaaa attatcaagg acaaggactt cctggacaat gaggaaaacg aggacattct     4200

ggaagatatc gtgctgaccc tgacactgtt tgaggacaga gagatgatcg aggaacggct     4260

gaaaacctat gcccacctgt tcgacgacaa agtgatgaag cagctgaagc ggcggagata     4320

caccggctgg ggcaggctga gccggaagct gatcaacggc atccgggaca agcagtccgg     4380

caagacaatc ctggatttcc tgaagtccga cggcttcgcc aacagaaact tcatgcagct     4440

gatccacgac gacagcctga cctttaaaga ggacatccag aaagcccagg tgtccggcca     4500

gggcgatagc ctgcacgagc acattgccaa tctggccggc agccccgcca ttaagaaggg     4560

catcctgcag acagtgaagg tggtggacga gctcgtgaaa gtgatgggcc ggcacaagcc     4620

cgagaacatc gtgatcgaaa tggccagaga gaaccagacc acccagaagg gacagaagaa     4680

cagccgcgag agaatgaagc ggatcgaaga gggcatcaaa gagctgggca gccagatcct     4740

gaaagaacac cccgtggaaa acacccagct gcagaacgag aagctgtacc tgtactacct     4800

gcagaatggg cgggatatgt acgtggacca ggaactggac atcaaccggc tgtccgacta     4860

cgatgtggac cacatcgtgc ctcagagctt tctgaaggac gactccatcg acaacaaggt     4920

gctgaccaga agcgacaagg cccggggcaa gagcgacaac gtgccctccg aagaggtcgt     4980

gaagaagatg aagaactact ggcggcagct gctgaacgcc aagctgatta cccagagaaa     5040

gttcgacaat ctgaccaagg ccgagagagg cggcctgagc gaactggata aggccggctt     5100

catcaagaga cagctggtgg aaacccggca gatcacaaag cacgtggcac agatcctgga     5160

ctcccggatg aacactaagt acgacgagaa tgacaagctg atccgggaag tgaaagtgat     5220

caccctgaag tccaagctgg tgtccgattt ccggaaggat ttccagtttt acaaagtgcg     5280

cgagatcaac aactaccacc acgcccacga cgcctacctg aacgccgtcg tgggaaccgc     5340

cctgatcaaa aagtacccta agctggaaag cgagttcgtg tacggcgact acaaggtgta     5400

cgacgtgcgg aagatgatcg ccaagagcga gcaggaaatc ggcaaggcta ccgccaagta     5460

cttcttctac agcaacatca tgaacttttt caagaccgag attaccctgg ccaacggcga     5520

gatccggaag cggcctctga tcgagacaaa cggcgaaacc ggggagatcg tgtgggataa     5580

gggccgggat tttgccaccg tgcggaaagt gctgagcatg ccccaagtga atatcgtgaa     5640

aaagaccgag gtgcagacag gcggcttcag caaagagtct atcctgccca agaggaacag     5700

cgataagctg atcgccagaa agaaggactg ggaccctaag aagtacggcg gcttcgacag     5760

ccccaccgtg gcctattctg tgctggtggt ggccaaagtg gaaaagggca agtccaagaa     5820

actgaagagt gtgaaagagc tgctggggat caccatcatg gaaagaagca gcttcgagaa     5880

gaatcccatc gactttctgg aagccaaggg ctacaaagaa gtgaaaaagg acctgatcat     5940

caagctgcct aagtactccc tgttcgagct ggaaaacggc cggaagagaa tgctggcctc     6000

tgccggcgaa ctgcagaagg gaaacgaact ggccctgccc tccaaatatg tgaacttcct     6060

gtacctggcc agccactatg agaagctgaa gggctccccc gaggataatg agcagaaaca     6120

gctgtttgtg gaacagcaca agcactacct ggacgagatc atcgagcaga tcagcgagtt     6180

ctccaagaga gtgatcctgg ccgacgctaa tctggacaaa gtgctgtccg cctacaacaa     6240

gcaccgggat aagcccatca gagagcaggc cgagaatatc atccacctgt ttaccctgac     6300

caatctggga gcccctgccg ccttcaagta ctttgacacc accatcgacc ggaagaggta     6360

caccagcacc aaagaggtgc tggacgccac cctgatccac cagagcatca ccggcctgta     6420

cgagacacgg atcgacctgt ctcagctggg aggcgacagc gctggaggag gtggaagcgg     6480

aggaggagga agcggaggag gaggtagcgg acctaagaaa aagaggaagg tggcggccgc     6540

tggatccgga cgggctgacg cattggacga ttttgatctg gatatgctgg gaagtgacgc     6600

cctcgatgat tttgaccttg acatgcttgg ttcggatgcc cttgatgact ttgacctcga     6660

catgctcggc agtgacgccc ttgatgattt cgacctggac atgctgatta actgtacagg     6720

cagtggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga atcctggccc     6780

aatggcttca aactttactc agttcgtgct cgtggacaat ggtgggacag gggatgtgac     6840

agtggctcct tctaatttcg ctaatggggt ggcagagtgg atcagctcca actcacggag     6900

ccaggcctac aaggtgacat gcagcgtcag gcagtctagt gcccagaaga gaaagtatac     6960

catcaaggtg gaggtcccca aagtggctac ccagacagtg ggcggagtcg aactgcctgt     7020

cgccgcttgg aggtcctacc tgaacatgga gctcactatc ccaattttcg ctaccaattc     7080

tgactgtgaa ctcatcgtga aggcaatgca ggggctcctc aaagacggta atcctatccc     7140

ttccgccatc gccgctaact caggtatcta cagcgctgga ggaggtggaa gcggaggagg     7200

aggaagcgga ggaggaggta gcggacctaa gaaaaagagg aaggtggcgg ccgctggatc     7260

cccttcaggg cagatcagca accaggccct ggctctggcc cctagctccg ctccagtgct     7320

ggcccagact atggtgccct ctagtgctat ggtgcctctg gcccagccac ctgctccagc     7380

ccctgtgctg accccaggac caccccagtc actgagcgct ccagtgccca agtctacaca     7440

ggccggcgag gggactctga gtgaagctct gctgcacctg cagttcgacg ctgatgagga     7500

cctgggagct ctgctgggga acagcaccga tcccggagtg ttcacagatc tggcctccgt     7560

ggacaactct gagtttcagc agctgctgaa tcagggcgtg tccatgtctc atagtacagc     7620

cgaaccaatg ctgatggagt accccgaagc cattacccgg ctggtgaccg gcagccagcg     7680

gccccccgac cccgctccaa ctcccctggg aaccagcggc ctgcctaatg ggctgtccgg     7740

agatgaagac ttctcaagca tcgctgatat ggactttagt gccctgctgt cacagatttc     7800

ctctagtggg cagggaggag gtggaagcgg cttcagcgtg gacaccagtg ccctgctgga     7860

cctgttcagc ccctcggtga ccgtgcccga catgagcctg cctgaccttg acagcagcct     7920

ggccagtatc caagagctcc tgtctcccca ggagcccccc aggcctcccg aggcagagaa     7980

cagcagcccg gattcaggga agcagctggt gcactacaca gcgcagccgc tgttcctgct     8040

ggaccccggc tccgtggaca ccgggagcaa cgacctgccg gtgctgtttg agctgggaga     8100

gggctcctac ttctccgaag gggacggctt cgccgaggac cccaccatct ccctgctgac     8160

aggctcggag cctcccaaag ccaaggaccc cactgtctcc tgagaattcg atatcaagct     8220

tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     8280

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     8340

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     8400

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     8460

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     8520

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     8580

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     8640

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     8700

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     8760

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg     8820

ataccgtcga cctcgacctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     8880

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     8940

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     9000

caggacagca agggggagga ttgggaagac aatggcaggc atg                       9043


<210>  119
<211>  3812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  First rox site

<220>
<221>  misc_feature
<222>  (111)..(710)
<223>  Puromycin-N-acetyltransferase

<220>
<221>  misc_feature
<222>  (797)..(2338)
<223>  Polyadenylation signal

<220>
<221>  misc_feature
<222>  (2363)..(2394)
<223>  Second rox site

<220>
<221>  misc_feature
<222>  (2401)..(2640)
<223>  First U6 promoter

<220>
<221>  misc_feature
<222>  (2641)..(2797)
<223>  First guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (2883)..(3122)
<223>  Second U6 promoter

<220>
<221>  misc_feature
<222>  (3123)..(3279)
<223>  Second guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (3364)..(3603)
<223>  Third U6 promoter

<220>
<221>  misc_feature
<222>  (3604)..(3760)
<223>  Third guide RNA coding sequence

<400>  119
taactttaaa taatgccaat tatttaaagt tacctgcagg acgtgttgac aattaatcat       60

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atgaccgagt      120

acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta cgcaccctcg      180

ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac cgccacatcg      240

agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg      300

tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag agcgtcgaag      360

cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt tcccggctgg      420

ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt      480

tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc agcgccgtcg      540

tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg gagacctccg      600

cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg      660

tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga cgcccgcccc      720

acgacccgca gcgcccgacc gaaaggagcg cacgacccca tgcatcgatg atctagagct      780

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc      840

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      900

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      960

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     1020

gcataacttc gtataatgta tgctatacgg gggatccgct gtaagtctgc agaaattgat     1080

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta     1140

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg     1200

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat     1260

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc     1320

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct     1380

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc     1440

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc     1500

aagttctaat tccatcagac ctcgacctgc agccgacgct aggtcgtcag tcaaagtacg     1560

tacctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc     1620

acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     1680

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     1740

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     1800

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     1860

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     1920

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     1980

ctttaacatc cctaaaattt tccttagatg ttttactagc cagatttttc ctcctctcct     2040

gactactccc agtcatagct gtccctcttc tcttatggag atccctcgag gacatgaggt     2100

cgtcgctgta atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     2160

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     2220

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     2280

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtcga     2340

cactgggtcg tgatcgggta cctaacttta aataatgcca attatttaaa gttagctagc     2400

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga     2460

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa     2520

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc     2580

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc     2640

nnnnnnnnnn nnnnnnnnnn gttttagagc taggccaaca tgaggatcac ccatgtctgc     2700

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac     2760

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat     2820

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc     2880

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg     2940

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     3000

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     3060

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     3120

ccnnnnnnnn nnnnnnnnnn nngttttaga gctaggccaa catgaggatc acccatgtct     3180

gcagggccta gcaagttaaa ataaggctag tccgttatca acttggccaa catgaggatc     3240

acccatgtct gcagggccaa gtggcaccga gtcggtgctt tttttgtttt agagctagaa     3300

atagcaagtt aaaataaggc tagtccgttt tatgcatgtg gctcccattt atacctggcc     3360

ggctttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     3420

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     3480

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     3540

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     3600

accnnnnnnn nnnnnnnnnn nnngttttag agctaggcca acatgaggat cacccatgtc     3660

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat     3720

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga     3780

aatagcaagt taaaataagg ctagtccgtt tt                                   3812


<210>  120
<211>  3814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  First rox site

<220>
<221>  misc_feature
<222>  (111)..(710)
<223>  Puromycin-N-acetyltransferase

<220>
<221>  misc_feature
<222>  (797)..(2338)
<223>  Polyadenylation signal

<220>
<221>  misc_feature
<222>  (2363)..(2394)
<223>  Second rox site

<220>
<221>  misc_feature
<222>  (2401)..(2640)
<223>  First U6 promoter

<220>
<221>  misc_feature
<222>  (2642)..(2798)
<223>  First Ttr guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (2884)..(3123)
<223>  Second U6 promoter

<220>
<221>  misc_feature
<222>  (3125)..(3281)
<223>  Second Ttr guide RNA coding sequence

<220>
<221>  misc_feature
<222>  (3366)..(3605)
<223>  Third U6 promoter

<220>
<221>  misc_feature
<222>  (3606)..(3762)
<223>  Third Ttr guide RNA coding sequence

<400>  120
taactttaaa taatgccaat tatttaaagt tacctgcagg acgtgttgac aattaatcat       60

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atgaccgagt      120

acaagcccac ggtgcgcctc gccacccgcg acgacgtccc cagggccgta cgcaccctcg      180

ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccggac cgccacatcg      240

agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg      300

tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag agcgtcgaag      360

cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt tcccggctgg      420

ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt      480

tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc agcgccgtcg      540

tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg gagacctccg      600

cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg      660

tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga cgcccgcccc      720

acgacccgca gcgcccgacc gaaaggagcg cacgacccca tgcatcgatg atctagagct      780

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc      840

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      900

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      960

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg     1020

gcataacttc gtataatgta tgctatacgg gggatccgct gtaagtctgc agaaattgat     1080

gatctattaa acaataaaga tgtccactaa aatggaagtt tttcctgtca tactttgtta     1140

agaagggtga gaacagagta cctacatttt gaatggaagg attggagcta cgggggtggg     1200

ggtggggtgg gattagataa atgcctgctc tttactgaag gctctttact attgctttat     1260

gataatgttt catagttgga tatcataatt taaacaagca aaaccaaatt aagggccagc     1320

tcattcctcc cactcatgat ctatagatct atagatctct cgtgggatca ttgtttttct     1380

cttgattccc actttgtggt tctaagtact gtggtttcca aatgtgtcag tttcatagcc     1440

tgaagaacga gatcagcagc ctctgttcca catacacttc attctcagta ttgttttgcc     1500

aagttctaat tccatcagac ctcgacctgc agccgacgct aggtcgtcag tcaaagtacg     1560

tacctcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat gccctggctc     1620

acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     1680

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     1740

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     1800

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     1860

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     1920

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     1980

ctttaacatc cctaaaattt tccttagatg ttttactagc cagatttttc ctcctctcct     2040

gactactccc agtcatagct gtccctcttc tcttatggag atccctcgag gacatgaggt     2100

cgtcgctgta atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     2160

acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     2220

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     2280

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtcga     2340

cactgggtcg tgatcgggta cctaacttta aataatgcca attatttaaa gttagctagc     2400

tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga     2460

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa     2520

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc     2580

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc     2640

gacggttgcc ctctttccca agttttagag ctaggccaac atgaggatca cccatgtctg     2700

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca     2760

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa     2820

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag     2880

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     2940

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     3000

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     3060

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     3120

accgactgtc agactcaaag gtgcgtttta gagctaggcc aacatgagga tcacccatgt     3180

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga     3240

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag     3300

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg     3360

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     3420

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     3480

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     3540

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     3600

acaccgacaa taagtagtct tactcgtttt agagctaggc caacatgagg atcacccatg     3660

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     3720

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     3780

gaaatagcaa gttaaaataa ggctagtccg tttt                                 3814


<210>  121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121
acggttgccc tctttcccaa                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122
actgtcagac tcaaaggtgc                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123
gacaataagt agtcttactc                                                   20


<210>  124
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
acgguugccc ucuuucccaa guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  125
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125
acugucagac ucaaaggugc guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  126
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126
gacaauaagu agucuuacuc guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  127
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcu                                                     137


<210>  128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128
acgguugccc ucuuucccaa                                                   20


<210>  129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129
acugucagac ucaaaggugc                                                   20


<210>  130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130
gacaauaagu agucuuacuc                                                   20


<210>  131
<211>  1965
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131

Met Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys 
1               5                   10                  15      


Lys Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Ala Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Ser  Ala Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly 
    1385                 1390                 1395             


Gly Gly  Ser Gly Pro Lys Lys  Lys Arg Lys Val Ala  Ala Ala Gly 
    1400                 1405                 1410             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1415                 1420                 1425             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1430                 1435                 1440             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1445                 1450                 1455             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Cys  Thr Gly Ser 
    1460                 1465                 1470             


Gly Glu  Gly Arg Gly Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu 
    1475                 1480                 1485             


Asn Pro  Gly Pro Met Ala Ser  Asn Phe Thr Gln Phe  Val Leu Val 
    1490                 1495                 1500             


Asp Asn  Gly Gly Thr Gly Asp  Val Thr Val Ala Pro  Ser Asn Phe 
    1505                 1510                 1515             


Ala Asn  Gly Val Ala Glu Trp  Ile Ser Ser Asn Ser  Arg Ser Gln 
    1520                 1525                 1530             


Ala Tyr  Lys Val Thr Cys Ser  Val Arg Gln Ser Ser  Ala Gln Lys 
    1535                 1540                 1545             


Arg Lys  Tyr Thr Ile Lys Val  Glu Val Pro Lys Val  Ala Thr Gln 
    1550                 1555                 1560             


Thr Val  Gly Gly Val Glu Leu  Pro Val Ala Ala Trp  Arg Ser Tyr 
    1565                 1570                 1575             


Leu Asn  Met Glu Leu Thr Ile  Pro Ile Phe Ala Thr  Asn Ser Asp 
    1580                 1585                 1590             


Cys Glu  Leu Ile Val Lys Ala  Met Gln Gly Leu Leu  Lys Asp Gly 
    1595                 1600                 1605             


Asn Pro  Ile Pro Ser Ala Ile  Ala Ala Asn Ser Gly  Ile Tyr Ser 
    1610                 1615                 1620             


Ala Gly  Gly Gly Gly Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1625                 1630                 1635             


Ser Gly  Pro Lys Lys Lys Arg  Lys Val Ala Ala Ala  Gly Ser Pro 
    1640                 1645                 1650             


Ser Gly  Gln Ile Ser Asn Gln  Ala Leu Ala Leu Ala  Pro Ser Ser 
    1655                 1660                 1665             


Ala Pro  Val Leu Ala Gln Thr  Met Val Pro Ser Ser  Ala Met Val 
    1670                 1675                 1680             


Pro Leu  Ala Gln Pro Pro Ala  Pro Ala Pro Val Leu  Thr Pro Gly 
    1685                 1690                 1695             


Pro Pro  Gln Ser Leu Ser Ala  Pro Val Pro Lys Ser  Thr Gln Ala 
    1700                 1705                 1710             


Gly Glu  Gly Thr Leu Ser Glu  Ala Leu Leu His Leu  Gln Phe Asp 
    1715                 1720                 1725             


Ala Asp  Glu Asp Leu Gly Ala  Leu Leu Gly Asn Ser  Thr Asp Pro 
    1730                 1735                 1740             


Gly Val  Phe Thr Asp Leu Ala  Ser Val Asp Asn Ser  Glu Phe Gln 
    1745                 1750                 1755             


Gln Leu  Leu Asn Gln Gly Val  Ser Met Ser His Ser  Thr Ala Glu 
    1760                 1765                 1770             


Pro Met  Leu Met Glu Tyr Pro  Glu Ala Ile Thr Arg  Leu Val Thr 
    1775                 1780                 1785             


Gly Ser  Gln Arg Pro Pro Asp  Pro Ala Pro Thr Pro  Leu Gly Thr 
    1790                 1795                 1800             


Ser Gly  Leu Pro Asn Gly Leu  Ser Gly Asp Glu Asp  Phe Ser Ser 
    1805                 1810                 1815             


Ile Ala  Asp Met Asp Phe Ser  Ala Leu Leu Ser Gln  Ile Ser Ser 
    1820                 1825                 1830             


Ser Gly  Gln Gly Gly Gly Gly  Ser Gly Phe Ser Val  Asp Thr Ser 
    1835                 1840                 1845             


Ala Leu  Leu Asp Leu Phe Ser  Pro Ser Val Thr Val  Pro Asp Met 
    1850                 1855                 1860             


Ser Leu  Pro Asp Leu Asp Ser  Ser Leu Ala Ser Ile  Gln Glu Leu 
    1865                 1870                 1875             


Leu Ser  Pro Gln Glu Pro Pro  Arg Pro Pro Glu Ala  Glu Asn Ser 
    1880                 1885                 1890             


Ser Pro  Asp Ser Gly Lys Gln  Leu Val His Tyr Thr  Ala Gln Pro 
    1895                 1900                 1905             


Leu Phe  Leu Leu Asp Pro Gly  Ser Val Asp Thr Gly  Ser Asn Asp 
    1910                 1915                 1920             


Leu Pro  Val Leu Phe Glu Leu  Gly Glu Gly Ser Tyr  Phe Ser Glu 
    1925                 1930                 1935             


Gly Asp  Gly Phe Ala Glu Asp  Pro Thr Ile Ser Leu  Leu Thr Gly 
    1940                 1945                 1950             


Ser Glu  Pro Pro Lys Ala Lys  Asp Pro Thr Val Ser  
    1955                 1960                 1965 


<210>  132
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  132
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcu                               157


<210>  133
<211>  5898
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4152)
<223>  dCas9

<220>
<221>  misc_feature
<222>  (4228)..(4414)
<223>  VP64

<220>
<221>  misc_feature
<222>  (4423)..(4476)
<223>  T2A

<220>
<221>  misc_feature
<222>  (4477)..(4866)
<223>  MCP

<220>
<221>  misc_feature
<222>  (4957)..(5499)
<223>  P65

<220>
<221>  misc_feature
<222>  (5524)..(5895)
<223>  HSF1

<400>  133
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggccat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caaggcccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggcg gccgctggat ccggacgggc tgacgcattg     4260

gacgattttg atctggatat gctgggaagt gacgccctcg atgattttga ccttgacatg     4320

cttggttcgg atgcccttga tgactttgac ctcgacatgc tcggcagtga cgcccttgat     4380

gatttcgacc tggacatgct gattaactgt acaggcagtg gagagggcag aggaagtctg     4440

ctaacatgcg gtgacgtcga ggagaatcct ggcccaatgg cttcaaactt tactcagttc     4500

gtgctcgtgg acaatggtgg gacaggggat gtgacagtgg ctccttctaa tttcgctaat     4560

ggggtggcag agtggatcag ctccaactca cggagccagg cctacaaggt gacatgcagc     4620

gtcaggcagt ctagtgccca gaagagaaag tataccatca aggtggaggt ccccaaagtg     4680

gctacccaga cagtgggcgg agtcgaactg cctgtcgccg cttggaggtc ctacctgaac     4740

atggagctca ctatcccaat tttcgctacc aattctgact gtgaactcat cgtgaaggca     4800

atgcaggggc tcctcaaaga cggtaatcct atcccttccg ccatcgccgc taactcaggt     4860

atctacagcg ctggaggagg tggaagcgga ggaggaggaa gcggaggagg aggtagcgga     4920

cctaagaaaa agaggaaggt ggcggccgct ggatcccctt cagggcagat cagcaaccag     4980

gccctggctc tggcccctag ctccgctcca gtgctggccc agactatggt gccctctagt     5040

gctatggtgc ctctggccca gccacctgct ccagcccctg tgctgacccc aggaccaccc     5100

cagtcactga gcgctccagt gcccaagtct acacaggccg gcgaggggac tctgagtgaa     5160

gctctgctgc acctgcagtt cgacgctgat gaggacctgg gagctctgct ggggaacagc     5220

accgatcccg gagtgttcac agatctggcc tccgtggaca actctgagtt tcagcagctg     5280

ctgaatcagg gcgtgtccat gtctcatagt acagccgaac caatgctgat ggagtacccc     5340

gaagccatta cccggctggt gaccggcagc cagcggcccc ccgaccccgc tccaactccc     5400

ctgggaacca gcggcctgcc taatgggctg tccggagatg aagacttctc aagcatcgct     5460

gatatggact ttagtgccct gctgtcacag atttcctcta gtgggcaggg aggaggtgga     5520

agcggcttca gcgtggacac cagtgccctg ctggacctgt tcagcccctc ggtgaccgtg     5580

cccgacatga gcctgcctga ccttgacagc agcctggcca gtatccaaga gctcctgtct     5640

ccccaggagc cccccaggcc tcccgaggca gagaacagca gcccggattc agggaagcag     5700

ctggtgcact acacagcgca gccgctgttc ctgctggacc ccggctccgt ggacaccggg     5760

agcaacgacc tgccggtgct gtttgagctg ggagagggct cctacttctc cgaaggggac     5820

ggcttcgccg aggaccccac catctccctg ctgacaggct cggagcctcc caaagccaag     5880

gaccccactg tctcctga                                                   5898


<210>  134
<211>  1412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(240)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (241)..(260)
<223>  Guide

<220>
<221>  misc_feature
<222>  (261)..(397)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (398)..(449)
<223>  Extended PolIII term

<220>
<221>  misc_feature
<222>  (483)..(722)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (723)..(742)
<223>  Guide

<220>
<221>  misc_feature
<222>  (743)..(879)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (880)..(931)
<223>  Extended PolIII term

<220>
<221>  misc_feature
<222>  (964)..(1203)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (1204)..(1223)
<223>  Guide

<220>
<221>  misc_feature
<222>  (1224)..(1360)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (1361)..(1412)
<223>  Extended PolIII term

<400>  134
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

nnnnnnnnnn nnnnnnnnnn gttttagagc taggccaaca tgaggatcac ccatgtctgc      300

agggcctagc aagttaaaat aaggctagtc cgttatcaac ttggccaaca tgaggatcac      360

ccatgtctgc agggccaagt ggcaccgagt cggtgctttt tttgttttag agctagaaat      420

agcaagttaa aataaggcta gtccgttttg agctccataa gactcggcct tagaacaagc      480

tttttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg      540

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat      600

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta      660

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca      720

ccnnnnnnnn nnnnnnnnnn nngttttaga gctaggccaa catgaggatc acccatgtct      780

gcagggccta gcaagttaaa ataaggctag tccgttatca acttggccaa catgaggatc      840

acccatgtct gcagggccaa gtggcaccga gtcggtgctt tttttgtttt agagctagaa      900

atagcaagtt aaaataaggc tagtccgttt tatgcatgtg gctcccattt atacctggcc      960

ggctttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     1020

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     1080

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     1140

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     1200

accnnnnnnn nnnnnnnnnn nnngttttag agctaggcca acatgaggat cacccatgtc     1260

tgcagggcct agcaagttaa aataaggcta gtccgttatc aacttggcca acatgaggat     1320

cacccatgtc tgcagggcca agtggcaccg agtcggtgct ttttttgttt tagagctaga     1380

aatagcaagt taaaataagg ctagtccgtt tt                                   1412


<210>  135
<211>  1414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
tttcccatga ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga       60

attaatttga ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa      120

tttcttgggt agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc      180

gtaacttgaa agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc      240

gacggttgcc ctctttccca agttttagag ctaggccaac atgaggatca cccatgtctg      300

cagggcctag caagttaaaa taaggctagt ccgttatcaa cttggccaac atgaggatca      360

cccatgtctg cagggccaag tggcaccgag tcggtgcttt ttttgtttta gagctagaaa      420

tagcaagtta aaataaggct agtccgtttt gagctccata agactcggcc ttagaacaag      480

ctttttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt      540

ggaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa      600

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt      660

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac      720

accgactgtc agactcaaag gtgcgtttta gagctaggcc aacatgagga tcacccatgt      780

ctgcagggcc tagcaagtta aaataaggct agtccgttat caacttggcc aacatgagga      840

tcacccatgt ctgcagggcc aagtggcacc gagtcggtgc tttttttgtt ttagagctag      900

aaatagcaag ttaaaataag gctagtccgt tttatgcatg tggctcccat ttatacctgg      960

ccggctttcc catgattcct tcatatttgc atatacgata caaggctgtt agagagataa     1020

ttggaattaa tttgactgta aacacaaaga tattagtaca aaatacgtga cgtagaaagt     1080

aataatttct tgggtagttt gcagttttaa aattatgttt taaaatggac tatcatatgc     1140

ttaccgtaac ttgaaagtat ttcgatttct tggctttata tatcttgtgg aaaggacgaa     1200

acaccgacaa taagtagtct tactcgtttt agagctaggc caacatgagg atcacccatg     1260

tctgcagggc ctagcaagtt aaaataaggc tagtccgtta tcaacttggc caacatgagg     1320

atcacccatg tctgcagggc caagtggcac cgagtcggtg ctttttttgt tttagagcta     1380

gaaatagcaa gttaaaataa ggctagtccg tttt                                 1414


<210>  136
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (28)..(267)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (269)..(288)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (289)..(425)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (426)..(477)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (511)..(750)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (752)..(771)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (772)..(908)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (909)..(960)
<223>  Extended terminator

<220>
<221>  misc_feature
<222>  (993)..(1232)
<223>  hU6 promoter

<220>
<221>  misc_feature
<222>  (1233)..(1252)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (1253)..(1389)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (1390)..(1441)
<223>  Extended terminator

<400>  136
gctagccata agactcggcc ttagaacttt cccatgattc cttcatattt gcatatacga       60

tacaaggctg ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta      120

caaaatacgt gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt      180

tttaaaatgg actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta      240

tatatcttgt ggaaaggacg aaacaccgac ggttgccctc tttcccaagt tttagagcta      300

ggccaacatg aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg      360

ttatcaactt ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg      420

gtgctttttt tgttttagag ctagaaatag caagttaaaa taaggctagt ccgttttgag      480

ctccataaga ctcggcctta gaacaagctt tttcccatga ttccttcata tttgcatata      540

cgatacaagg ctgttagaga gataattgga attaatttga ctgtaaacac aaagatatta      600

gtacaaaata cgtgacgtag aaagtaataa tttcttgggt agtttgcagt tttaaaatta      660

tgttttaaaa tggactatca tatgcttacc gtaacttgaa agtatttcga tttcttggct      720

ttatatatct tgtggaaagg acgaaacacc gactgtcaga ctcaaaggtg cgttttagag      780

ctaggccaac atgaggatca cccatgtctg cagggcctag caagttaaaa taaggctagt      840

ccgttatcaa cttggccaac atgaggatca cccatgtctg cagggccaag tggcaccgag      900

tcggtgcttt ttttgtttta gagctagaaa tagcaagtta aaataaggct agtccgtttt      960

atgcatgtgg ctcccattta tacctggccg gctttcccat gattccttca tatttgcata     1020

tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac acaaagatat     1080

tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca gttttaaaat     1140

tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc gatttcttgg     1200

ctttatatat cttgtggaaa ggacgaaaca ccgacaataa gtagtcttac tcgttttaga     1260

gctaggccaa catgaggatc acccatgtct gcagggccta gcaagttaaa ataaggctag     1320

tccgttatca acttggccaa catgaggatc acccatgtct gcagggccaa gtggcaccga     1380

gtcggtgctt tttttgtttt agagctagaa atagcaagtt aaaataaggc tagtccgttt     1440

tggtcaccca gtgaggaagc taggacagac ctaggacggt tgcctgcagg                1490


<210>  137
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide1

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  137
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga cggttgccct ctttcccaag ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  138
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (320)..(339)
<223>  Guide2

<220>
<221>  misc_feature
<222>  (340)..(476)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (477)..(482)
<223>  Small terminator

<400>  138
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga ctgtcagact caaaggtgcg ttttagagct aggccaacat      360

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact      420

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt      480

ttctagaggc                                                             490


<210>  139
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  mU6 promoter

<220>
<221>  misc_feature
<222>  (319)..(338)
<223>  Guide3

<220>
<221>  misc_feature
<222>  (339)..(475)
<223>  SAM Tracr

<220>
<221>  misc_feature
<222>  (476)..(481)
<223>  Small terminator

<400>  139
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga caataagtag tcttactcgt tttagagcta ggccaacatg      360

aggatcaccc atgtctgcag ggcctagcaa gttaaaataa ggctagtccg ttatcaactt      420

ggccaacatg aggatcaccc atgtctgcag ggccaagtgg caccgagtcg gtgctttttt      480

tctagaggc                                                              489


<210>  140
<211>  139
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
guuuuagagc uaggccaaca ugaggaucac ccaugucugc agggccuagc aaguuaaaau       60

aaggcuaguc cguuaucaac uuggccaaca ugaggaucac ccaugucugc agggccaagu      120

ggcaccgagu cggugcuuu                                                   139


<210>  141
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  141
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaggccaaca ugaggaucac ccaugucugc       60

agggccuagc aaguuaaaau aaggcuaguc cguuaucaac uuggccaaca ugaggaucac      120

ccaugucugc agggccaagu ggcaccgagu cggugcuuu                             159


<210>  142
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
guuuuagagc uaugcu                                                       16


<210>  143
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  144
<211>  72
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
aaacagcaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa guggcaccga       60

gucggugcuu uu                                                           72


<210>  145
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210>  146
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcu                                                      77


<210>  147
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210>  148
<211>  76
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  149
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugc                                            86


<210>  150
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uuu                                               83


<210>  151
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  152
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


<210>  153
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  n is a, c, g, or t

<400>  153
gnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  154
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n is a, c, g, or t

<400>  154
nnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  155
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(23)
<223>  n is a, c, g, or t

<400>  155
ggnnnnnnnn nnnnnnnnnn nnngg                                             25


