                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Fu, Haiyan
       Bobo, Tierra
 
<120>  AAV-NAGLU Vectors for Treatment of Mucopolysaccharidosis IIIB

<130>  5470.878.WO

<150>  US 62/993,266
<151>  2020-03-23

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2232
<212>  DNA
<213>  Artificial

<220>
<223>  codon-optimized alpha-N-acetylglucosaminidase

<400>  1
atggaggctg ttgctgttgc agccgctgtg ggcgtcttgc tgttggccgg tgccggggga       60

gctgctggcg acgaggcaag ggaagctgca gctgtgcggg ctctcgtcgc aaggttgctg      120

ggtccaggtc ccgctgctga ctttagtgtg tcagtggaga gggctttggc cgctaaacct      180

ggcctggaca cctactccct gggtggaggt ggggctgccc gcgtgagggt gagaggctca      240

acgggggtgg ctgctgcagc aggtctgcat aggtacctca gagacttctg cggatgccat      300

gtcgcttgga gcggcagtca actgaggctg ccccggcccc tccctgccgt ccctggggaa      360

cttacagaag ctactccaaa taggtacaga tattatcaaa atgtgtgtac gcagagttac      420

agctttgtgt ggtgggactg ggcaaggtgg gagcgcgaaa tcgattggat ggccctcaac      480

gggatcaatc tggccttggc atggtccgga caggaagcta tctggcagcg cgtgtatctg      540

gctctcgggt tgactcaagc tgaaatcaac gagtttttca caggccccgc cttcctggcc      600

tgggggcgga tgggtaatct tcatacttgg gacgggccac tgcccccctc ttggcacatc      660

aaacagttgt atctgcagca ccgcgtcctg gaccagatgc gcagcttcgg catgactccc      720

gtcctgccgg ctttcgcagg gcacgtccca gaggcggtca cacgggtctt ccctcaggtg      780

aatgtgacaa aaatgggatc atggggacat ttcaattgtt cttacagttg ttccttcctg      840

ctggcacccg aagatcctat cttcccaatc ataggaagtc tctttctgcg cgagttgatt      900

aaggagttcg gtactgatca catttatggc gctgatactt ttaacgaaat gcagcccccc      960

tcttctgaac catcctatct tgctgccgca accactgccg tttatgaagc catgaccgcc     1020

gtggacactg aagccgtttg gcttctccaa ggttggctgt tccagcacca gcctcagttt     1080

tgggggccag ctcagataag agccgttctc ggcgctgtac ctcgcggaag actgctggtg     1140

cttgatttgt tcgcagagtc tcagccagtg tacacgagaa ccgcttcctt ccagggccag     1200

ccgtttattt ggtgtatgct tcacaatttt ggcggaaatc atgggctgtt cggtgccctg     1260

gaggccgtca atgggggacc tgaggctgca agattgttcc caaactcaac catggtgggg     1320

accggaatgg cacccgaagg cattagccag aatgaggtcg tctacagtct gatggcggaa     1380

ttggggtggc ggaaggaccc cgtgccagat ctcgccgcct gggtgactag ctttgccgcc     1440

cgccgctatg gagtgagcca tcctgatgca ggcgcagcct ggcggctgtt gcttcgatca     1500

gtatacaatt gttcaggaga ggcctgccgg gggcacaata ggagcccact ggtaaggagg     1560

cccagcctgc agatgaacac ctctatctgg tacaacagaa gcgatgtttt cgaggcttgg     1620

agacttctcc ttacatctgc ccctagcttg gccaccagtc cagccttccg atatgatctg     1680

ctggacctca cccgacaggc cgtgcaggaa ctggtctctc tctactatga agaggccaga     1740

tcagcttacc tctctaaaga actggcctcc ctcttgcgag caggaggcgt cctggcatat     1800

gagctgctcc ctgcactgga cgaggtactg gcatctgatt cccgattcct gctcgggtca     1860

tggctggagc aagcccgagc agcggctgta agcgaggctg aagcagactt ctatgaacaa     1920

aatagtaggt atcaactgac tctgtggggt ccagagggga atatcctgga ctacgcgaac     1980

aaacagttgg cgggcctggt ggccaactac tacacccctc ggtggagatt gtttttggag     2040

gcgctggtgg attcagtcgc acaggggatt ccgtttcagc aacatcagtt tgacaagaac     2100

gtctttcagc tggaacaggc ttttgtgctt tctaagcagc gctacccttc tcagccaaga     2160

ggcgataccg ttgacctcgc gaagaaaatc tttctcaagt actatcccag atgggtggcc     2220

ggatcatggt ag                                                         2232


<210>  2
<211>  2232
<212>  DNA
<213>  Homo sapiens

<400>  2
atggaggcgg tggcggtggc cgcggcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgaggcccg ggaggcggcg gccgtgcggg cgctcgtggc ccggctgctg      120

gggccaggcc ccgcggccga cttctccgtg tcggtggagc gcgctctggc tgccaagccg      180

ggcttggaca cctacagcct gggcggcggc ggcgcggcgc gcgtgcgggt gcgcggctcc      240

acgggcgtgg cggccgccgc ggggctgcac cgctacctgc gcgacttctg tggctgccac      300

gtggcctggt ccggctctca gctgcgcctg ccgcggccac tgccagccgt gccgggggag      360

ctgaccgagg ccacgcccaa caggtaccgc tattaccaga atgtgtgcac gcaaagctac      420

tccttcgtgt ggtgggactg ggcccgctgg gagcgagaga tagactggat ggcgctgaat      480

ggcatcaacc tggcactggc ctggagcggc caggaggcca tctggcagcg ggtgtacctg      540

gccttgggcc tgacccaggc agagatcaat gagttcttta ctggtcctgc cttcctggcc      600

tgggggcgaa tgggcaacct gcacacctgg gatggccccc tgcccccctc ctggcacatc      660

aagcagcttt acctgcagca ccgggtcctg gaccagatgc gctccttcgg catgacccca      720

gtgctgcctg cattcgcggg gcatgttccc gaggctgtca ccagggtgtt ccctcaggtc      780

aatgtcacga agatgggcag ttggggccac tttaactgtt cctactcctg ctccttcctt      840

ctggctccgg aagaccccat attccccatc atcgggagcc tcttcctgcg agagctgatc      900

aaagagtttg gcacagacca catctatggg gccgacactt tcaatgagat gcagccacct      960

tcctcagagc cctcctacct tgccgcagcc accactgccg tctatgaggc catgactgca     1020

gtggatactg aggctgtgtg gctgctccaa ggctggctct tccagcacca gccgcagttc     1080

tgggggcccg cccagatcag ggctgtgctg ggagctgtgc cccgtggccg cctcctggtt     1140

ctggacctgt ttgctgagag ccagcctgtg tatacccgca ctgcctcctt ccagggccag     1200

cccttcatct ggtgcatgct gcacaacttt gggggaaacc atggtctttt tggagcccta     1260

gaggctgtga acggaggccc agaagctgcc cgcctcttcc ccaactccac catggtaggc     1320

acgggcatgg cccccgaggg catcagccag aacgaagtgg tctattccct catggctgag     1380

ctgggctggc gaaaggaccc agtgccagat ttggcagcct gggtgaccag ctttgccgcc     1440

cggcggtatg gggtctccca cccggacgca ggggcagcgt ggaggctact gctccggagt     1500

gtgtacaact gctccgggga ggcctgcagg ggccacaatc gtagcccgct ggtcaggcgg     1560

ccgtccctac agatgaatac cagcatctgg tacaaccgat ctgatgtgtt tgaggcctgg     1620

cggctgctgc tcacatctgc tccctccctg gccaccagcc ccgccttccg ctacgacctg     1680

ctggacctca ctcggcaggc agtgcaggag ctggtcagct tgtactatga ggaggcaaga     1740

agcgcctacc tgagcaagga gctggcctcc ctgttgaggg ctggaggcgt cctggcctat     1800

gagctgctgc cggcactgga cgaggtgctg gctagtgaca gccgcttctt gctgggcagc     1860

tggctagagc aggcccgagc agcggcagtc agtgaggccg aggccgattt ctacgagcag     1920

aacagccgct accagctgac cttgtggggg ccagaaggca acatcctgga ctatgccaac     1980

aagcagctgg cggggttggt ggccaactac tacacccctc gctggcggct tttcctggag     2040

gcgctggttg acagtgtggc ccagggcatc cctttccaac agcaccagtt tgacaaaaat     2100

gtcttccaac tggagcaggc cttcgttctc agcaagcaga ggtaccccag ccagccgcga     2160

ggagacactg tggacctggc caagaagatc ttcctcaaat attaccccgg ctgggtggcc     2220

ggctcttggt ga                                                         2232


<210>  3
<211>  7730
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid

<400>  3
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg gaagctgatc      180

ttcaatattg gccattagcc atattattca ttggttatat agcataaatc aatattggat      240

attggccatt gcatacgttg tatctatatc ataatatgta catttatatt ggctcatgtc      300

caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa tcaattacgg      360

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      420

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      480

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg      540

cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt gacgtcaatg      600

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac tttcctactt      660

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc cccacgttct      720

gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta tttatttttt      780

aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca ggcggggcgg      840

ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg      900

gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc tataaaaagc      960

gaagcgcgcg gcgggcggga gtcgctgcga cgctgccttc gccccgtgcc ccgctccgcc     1020

gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt tactcccaca ggtgagcggg     1080

cgggacggcc cttctcctcc gggctgtaat tagcgcttgg tttaatgacg gcttgtttct     1140

tttctgtggc tgcgtgaaag ccttgagggg ctccgggagg gccctttgtg cgggggggag     1200

cggctcgggg ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg     1260

cccggcggct gtgagcgctg cgggcgcggc gcggggcttt gtgcgctccg cagtgtgcgc     1320

gaggggagcg cggccggggg cggtgccccg cggtgcgggg ggggctgcga ggggaacaaa     1380

ggctgcgtgc ggggtgtgtg cgtggggggg tgagcagggg gtatgggcgc ggcggtcggg     1440

ctgtaacccc cccctgcacc cccctccccg agttgctgag cacggcccgg cttcgggtgc     1500

ggggctccgt acggggcgtg gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt     1560

gggggtgccg ggcggggcgg ggccgcctcg ggccggggag ggctcggggg aggggcgcgg     1620

cggcccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1680

gtaatcgtgc gagagggcgc agggacttac tttgtcccaa atctgtgcgg agccgaaatc     1740

tgggaggcgc cgccgcaccc cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag     1800

gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct     1860

ccagcctcgg ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg     1920

gttcggcttc tggcgtgtga ccggcggctc tagagcctct gctaaccatg ttcatgcctt     1980

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     2040

caaagaattc gataggatcc ggtactcgag gaactgaaaa accagaaagt taactggtaa     2100

gtttagtctt tttgtctttt atttcaggtc ccggatccgg tggtggtgca aatcaaagaa     2160

ctgctcctca gtggatgttg cctttacttc taggcctgta cggaagtgtt acttctgctc     2220

taaaagctgc ggaattgtac ccgcggcccg ggatccaccg gccaccggta ttcgcagacc     2280

atggaggctg ttgctgttgc agccgctgtg ggcgtcttgc tgttggccgg tgccggggga     2340

gctgctggcg acgaggcaag ggaagctgca gctgtgcggg ctctcgtcgc aaggttgctg     2400

ggtccaggtc ccgctgctga ctttagtgtg tcagtggaga gggctttggc cgctaaacct     2460

ggcctggaca cctactccct gggtggaggt ggggctgccc gcgtgagggt gagaggctca     2520

acgggggtgg ctgctgcagc aggtctgcat aggtacctca gagacttctg cggatgccat     2580

gtcgcttgga gcggcagtca actgaggctg ccccggcccc tccctgccgt ccctggggaa     2640

cttacagaag ctactccaaa taggtacaga tattatcaaa atgtgtgtac gcagagttac     2700

agctttgtgt ggtgggactg ggcaaggtgg gagcgcgaaa tcgattggat ggccctcaac     2760

gggatcaatc tggccttggc atggtccgga caggaagcta tctggcagcg cgtgtatctg     2820

gctctcgggt tgactcaagc tgaaatcaac gagtttttca caggccccgc cttcctggcc     2880

tgggggcgga tgggtaatct tcatacttgg gacgggccac tgcccccctc ttggcacatc     2940

aaacagttgt atctgcagca ccgcgtcctg gaccagatgc gcagcttcgg catgactccc     3000

gtcctgccgg ctttcgcagg gcacgtccca gaggcggtca cacgggtctt ccctcaggtg     3060

aatgtgacaa aaatgggatc atggggacat ttcaattgtt cttacagttg ttccttcctg     3120

ctggcacccg aagatcctat cttcccaatc ataggaagtc tctttctgcg cgagttgatt     3180

aaggagttcg gtactgatca catttatggc gctgatactt ttaacgaaat gcagcccccc     3240

tcttctgaac catcctatct tgctgccgca accactgccg tttatgaagc catgaccgcc     3300

gtggacactg aagccgtttg gcttctccaa ggttggctgt tccagcacca gcctcagttt     3360

tgggggccag ctcagataag agccgttctc ggcgctgtac ctcgcggaag actgctggtg     3420

cttgatttgt tcgcagagtc tcagccagtg tacacgagaa ccgcttcctt ccagggccag     3480

ccgtttattt ggtgtatgct tcacaatttt ggcggaaatc atgggctgtt cggtgccctg     3540

gaggccgtca atgggggacc tgaggctgca agattgttcc caaactcaac catggtgggg     3600

accggaatgg cacccgaagg cattagccag aatgaggtcg tctacagtct gatggcggaa     3660

ttggggtggc ggaaggaccc cgtgccagat ctcgccgcct gggtgactag ctttgccgcc     3720

cgccgctatg gagtgagcca tcctgatgca ggcgcagcct ggcggctgtt gcttcgatca     3780

gtatacaatt gttcaggaga ggcctgccgg gggcacaata ggagcccact ggtaaggagg     3840

cccagcctgc agatgaacac ctctatctgg tacaacagaa gcgatgtttt cgaggcttgg     3900

agacttctcc ttacatctgc ccctagcttg gccaccagtc cagccttccg atatgatctg     3960

ctggacctca cccgacaggc cgtgcaggaa ctggtctctc tctactatga agaggccaga     4020

tcagcttacc tctctaaaga actggcctcc ctcttgcgag caggaggcgt cctggcatat     4080

gagctgctcc ctgcactgga cgaggtactg gcatctgatt cccgattcct gctcgggtca     4140

tggctggagc aagcccgagc agcggctgta agcgaggctg aagcagactt ctatgaacaa     4200

aatagtaggt atcaactgac tctgtggggt ccagagggga atatcctgga ctacgcgaac     4260

aaacagttgg cgggcctggt ggccaactac tacacccctc ggtggagatt gtttttggag     4320

gcgctggtgg attcagtcgc acaggggatt ccgtttcagc aacatcagtt tgacaagaac     4380

gtctttcagc tggaacaggc ttttgtgctt tctaagcagc gctacccttc tcagccaaga     4440

ggcgataccg ttgacctcgc gaagaaaatc tttctcaagt actatcccag atgggtggcc     4500

ggatcatggt aggtcgaccc tcgactagag ctcgctgatc agcctcgact gtgccttcta     4560

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     4620

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     4680

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     4740

gcaggcatgc tggggagaga tctaggaacc cctagtgatg gagttggcca ctccctctct     4800

gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg     4860

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaacc cccccccccc     4920

cccccctgca gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca     4980

gttgcgtagc ctgaatggcg aatggcgcga cgcgccctgt agcggcgcat taagcgcggc     5040

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     5100

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     5160

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     5220

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     5280

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     5340

ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     5400

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttac     5460

aatttcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg     5520

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca     5580

acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct     5640

gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg     5700

agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt     5760

tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     5820

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     5880

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     5940

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     6000

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     6060

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     6120

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     6180

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     6240

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     6300

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     6360

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     6420

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     6480

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     6540

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     6600

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     6660

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatgacctt ccagggtcaa     6720

ggaagctgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     6780

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     6840

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     6900

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     6960

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     7020

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga     7080

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     7140

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     7200

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     7260

ccgaactgag atacctacag cgtgagcatt gagaaagcgc cacgcttccc gaagggagaa     7320

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     7380

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     7440

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     7500

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     7560

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     7620

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca     7680

aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctgggctgca                7730


<210>  4
<211>  6460
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid

<400>  4
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

ccgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      240

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      300

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      360

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      420

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      480

ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg      540

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac      600

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg      660

tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac      720

gccatccacg ctgttttgac ctccatagaa gacaccggga ccgatccagc ctccggactc      780

tagaggatcc ggtactcgag gaactgaaaa accagaaagt taactggtaa gtttagtctt      840

tttgtctttt atttcaggtc ccggatccgg tggtggtgca aatcaaagaa ctgctcctca      900

gtggatgttg cctttacttc taggcctgta cggaagtgtt acttctgctc taaaagctgc      960

ggaattgtac ccgcggcccg ggatccaccg gccaccggta ttcgcagacc atggaggctg     1020

ttgctgttgc agccgctgtg ggcgtcttgc tgttggccgg tgccggggga gctgctggcg     1080

acgaggcaag ggaagctgca gctgtgcggg ctctcgtcgc aaggttgctg ggtccaggtc     1140

ccgctgctga ctttagtgtg tcagtggaga gggctttggc cgctaaacct ggcctggaca     1200

cctactccct gggtggaggt ggggctgccc gcgtgagggt gagaggctca acgggggtgg     1260

ctgctgcagc aggtctgcat aggtacctca gagacttctg cggatgccat gtcgcttgga     1320

gcggcagtca actgaggctg ccccggcccc tccctgccgt ccctggggaa cttacagaag     1380

ctactccaaa taggtacaga tattatcaaa atgtgtgtac gcagagttac agctttgtgt     1440

ggtgggactg ggcaaggtgg gagcgcgaaa tcgattggat ggccctcaac gggatcaatc     1500

tggccttggc atggtccgga caggaagcta tctggcagcg cgtgtatctg gctctcgggt     1560

tgactcaagc tgaaatcaac gagtttttca caggccccgc cttcctggcc tgggggcgga     1620

tgggtaatct tcatacttgg gacgggccac tgcccccctc ttggcacatc aaacagttgt     1680

atctgcagca ccgcgtcctg gaccagatgc gcagcttcgg catgactccc gtcctgccgg     1740

ctttcgcagg gcacgtccca gaggcggtca cacgggtctt ccctcaggtg aatgtgacaa     1800

aaatgggatc atggggacat ttcaattgtt cttacagttg ttccttcctg ctggcacccg     1860

aagatcctat cttcccaatc ataggaagtc tctttctgcg cgagttgatt aaggagttcg     1920

gtactgatca catttatggc gctgatactt ttaacgaaat gcagcccccc tcttctgaac     1980

catcctatct tgctgccgca accactgccg tttatgaagc catgaccgcc gtggacactg     2040

aagccgtttg gcttctccaa ggttggctgt tccagcacca gcctcagttt tgggggccag     2100

ctcagataag agccgttctc ggcgctgtac ctcgcggaag actgctggtg cttgatttgt     2160

tcgcagagtc tcagccagtg tacacgagaa ccgcttcctt ccagggccag ccgtttattt     2220

ggtgtatgct tcacaatttt ggcggaaatc atgggctgtt cggtgccctg gaggccgtca     2280

atgggggacc tgaggctgca agattgttcc caaactcaac catggtgggg accggaatgg     2340

cacccgaagg cattagccag aatgaggtcg tctacagtct gatggcggaa ttggggtggc     2400

ggaaggaccc cgtgccagat ctcgccgcct gggtgactag ctttgccgcc cgccgctatg     2460

gagtgagcca tcctgatgca ggcgcagcct ggcggctgtt gcttcgatca gtatacaatt     2520

gttcaggaga ggcctgccgg gggcacaata ggagcccact ggtaaggagg cccagcctgc     2580

agatgaacac ctctatctgg tacaacagaa gcgatgtttt cgaggcttgg agacttctcc     2640

ttacatctgc ccctagcttg gccaccagtc cagccttccg atatgatctg ctggacctca     2700

cccgacaggc cgtgcaggaa ctggtctctc tctactatga agaggccaga tcagcttacc     2760

tctctaaaga actggcctcc ctcttgcgag caggaggcgt cctggcatat gagctgctcc     2820

ctgcactgga cgaggtactg gcatctgatt cccgattcct gctcgggtca tggctggagc     2880

aagcccgagc agcggctgta agcgaggctg aagcagactt ctatgaacaa aatagtaggt     2940

atcaactgac tctgtggggt ccagagggga atatcctgga ctacgcgaac aaacagttgg     3000

cgggcctggt ggccaactac tacacccctc ggtggagatt gtttttggag gcgctggtgg     3060

attcagtcgc acaggggatt ccgtttcagc aacatcagtt tgacaagaac gtctttcagc     3120

tggaacaggc ttttgtgctt tctaagcagc gctacccttc tcagccaaga ggcgataccg     3180

ttgacctcgc gaagaaaatc tttctcaagt actatcccag atgggtggcc ggatcatggt     3240

aggtcgaccc tcgactagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     3300

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     3360

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     3420

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3480

tggggagaga tctaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     3540

tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc     3600

tcagtgagcg agcgagcgcg cagagaggga gtggccaacc cccccccccc cccccctgca     3660

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgtagc     3720

ctgaatggcg aatggcgcga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     3780

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     3840

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     3900

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     3960

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4020

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4080

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag     4140

ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aatttcctga     4200

tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca     4260

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg     4320

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     4380

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     4440

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt     4500

caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     4560

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     4620

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     4680

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     4740

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     4800

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     4860

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     4920

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     4980

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     5040

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     5100

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     5160

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     5220

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     5280

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     5340

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     5400

tagttatcta cacgacgggg agtcaggcaa ctatgacctt ccagggtcaa ggaagctgtc     5460

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag     5520

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     5580

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     5640

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     5700

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     5760

accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     5820

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     5880

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     5940

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     6000

atacctacag cgtgagcatt gagaaagcgc cacgcttccc gaagggagaa aggcggacag     6060

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     6120

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     6180

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     6240

gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc     6300

tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac     6360

cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct     6420

ccccgcgcgt tggccgattc attaatgcag ctgggctgca                           6460


