                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
 
<120>  SUBSTITUTED OXOISOINDOLINE COMPOUNDS

<130>  13397-WO-PCT

<150>  US62/993,144
<151>  2020-03-23

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu 
            100                 105                 110         


Lys Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met 
        115                 120                 125             


Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln 
    130                 135                 140                 


Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys 
145                 150                 155                 160 


Leu His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Ser Tyr Ala 
                165                 170                 175     


Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val 
            180                 185                 190         


Gly Lys Pro His Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Arg 
        195                 200                 205             


Ser Ser Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Asn 
    210                 215                 220                 


Val Ser Met Glu Ala Ala Gly Gln Val Met Ser His His Val Pro Pro 
225                 230                 235                 240 


Met Glu Asp Cys Lys Glu Gln Glu Pro Ile Met Asp Asn Asn Ile Ser 
                245                 250                 255     


Leu Val Pro Phe Glu Arg Pro Ala Val Ile Glu Lys Leu Thr Gly Asn 
            260                 265                 270         


Met Gly Lys Arg Lys Ser Ser Thr Pro Gln Lys Phe Val Gly Glu Lys 
        275                 280                 285             


Leu Met Arg Phe Ser Tyr Pro Asp Ile His Phe Asp Met Asn Leu Thr 
    290                 295                 300                 


Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser His Met Met Asp Gln Ala 
305                 310                 315                 320 


Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala Glu Ala Leu His Pro Leu 
                325                 330                 335     


Met Gln His Pro Pro Ser Thr Ile Ala Glu Val Ala Pro Val Ile Ser 
            340                 345                 350         


Ser Ala Tyr Ser Gln Val Tyr His Pro Asn Arg Ile Glu Arg Pro Ile 
        355                 360                 365             


Ser Arg Glu Thr Ala Asp Ser His Glu Asn Asn Met Asp Gly Pro Ile 
    370                 375                 380                 


Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln Glu Arg Glu Ala Ser Pro 
385                 390                 395                 400 


Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser Glu Ser Ser His Asp Asp 
                405                 410                 415     


His Gln Ser Tyr Gln Gly His Pro Ala Leu Asn Pro Lys Arg Lys Gln 
            420                 425                 430         


Ser Pro Ala Tyr Met Lys Glu Asp Val Lys Ala Leu Asp Thr Thr Lys 
        435                 440                 445             


Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr Lys Val Phe Asn Gly Glu 
    450                 455                 460                 


Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu His Cys Arg Val Leu Phe 
465                 470                 475                 480 


Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys His Gly Tyr Arg 
                485                 490                 495     


Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr Arg Ser Gln Asp Arg Tyr 
            500                 505                 510         


Glu Phe Ser Ser His Ile Val Arg Gly Glu His Thr Phe His 
        515                 520                 525     


<210>  2
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Glu Arg 
            100                 105                 110         


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
        115                 120                 125             


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
    130                 135                 140                 


Pro Phe Cys Ser Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
145                 150                 155                 160 


Leu Arg Thr His Ser Val Gly Lys Pro His Lys Cys Asn Tyr Cys Gly 
                165                 170                 175     


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
            180                 185                 190         


His Asn Tyr Leu Gln Asn Val Ser Met Glu Ala Ala Gly Gln Val Met 
        195                 200                 205             


Ser His His Val Pro Pro Met Glu Asp Cys Lys Glu Gln Glu Pro Ile 
    210                 215                 220                 


Met Asp Asn Asn Ile Ser Leu Val Pro Phe Glu Arg Pro Ala Val Ile 
225                 230                 235                 240 


Glu Lys Leu Thr Gly Asn Met Gly Lys Arg Lys Ser Ser Thr Pro Gln 
                245                 250                 255     


Lys Phe Val Gly Glu Lys Leu Met Arg Phe Ser Tyr Pro Asp Ile His 
            260                 265                 270         


Phe Asp Met Asn Leu Thr Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser 
        275                 280                 285             


His Met Met Asp Gln Ala Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala 
    290                 295                 300                 


Glu Ala Leu His Pro Leu Met Gln His Pro Pro Ser Thr Ile Ala Glu 
305                 310                 315                 320 


Val Ala Pro Val Ile Ser Ser Ala Tyr Ser Gln Val Tyr His Pro Asn 
                325                 330                 335     


Arg Ile Glu Arg Pro Ile Ser Arg Glu Thr Ala Asp Ser His Glu Asn 
            340                 345                 350         


Asn Met Asp Gly Pro Ile Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln 
        355                 360                 365             


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser 
    370                 375                 380                 


Glu Ser Ser His Asp Asp His Gln Ser Tyr Gln Gly His Pro Ala Leu 
385                 390                 395                 400 


Asn Pro Lys Arg Lys Gln Ser Pro Ala Tyr Met Lys Glu Asp Val Lys 
                405                 410                 415     


Ala Leu Asp Thr Thr Lys Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr 
            420                 425                 430         


Lys Val Phe Asn Gly Glu Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu 
        435                 440                 445             


His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met 
    450                 455                 460                 


Gly Cys His Gly Tyr Arg Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr 
465                 470                 475                 480 


Arg Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu 
                485                 490                 495     


His Thr Phe His 
            500 


<210>  3
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Glu Arg 
            100                 105                 110         


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
        115                 120                 125             


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
    130                 135                 140                 


Pro Phe Cys Ser Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
145                 150                 155                 160 


Leu Arg Thr His Ser Val Gly Lys Pro His Lys Cys Asn Tyr Cys Gly 
                165                 170                 175     


Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys 
            180                 185                 190         


His Asn Tyr Leu Gln Asn Val Ser Met Glu Ala Ala Gly Gln Val Met 
        195                 200                 205             


Ser His His Gly Glu Lys Leu Met Arg Phe Ser Tyr Pro Asp Ile His 
    210                 215                 220                 


Phe Asp Met Asn Leu Thr Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser 
225                 230                 235                 240 


His Met Met Asp Gln Ala Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala 
                245                 250                 255     


Glu Ala Leu His Pro Leu Met Gln His Pro Pro Ser Thr Ile Ala Glu 
            260                 265                 270         


Val Ala Pro Val Ile Ser Ser Ala Tyr Ser Gln Val Tyr His Pro Asn 
        275                 280                 285             


Arg Ile Glu Arg Pro Ile Ser Arg Glu Thr Ala Asp Ser His Glu Asn 
    290                 295                 300                 


Asn Met Asp Gly Pro Ile Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln 
305                 310                 315                 320 


Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser 
                325                 330                 335     


Glu Ser Ser His Asp Asp His Gln Ser Tyr Gln Gly His Pro Ala Leu 
            340                 345                 350         


Asn Pro Lys Arg Lys Gln Ser Pro Ala Tyr Met Lys Glu Asp Val Lys 
        355                 360                 365             


Ala Leu Asp Thr Thr Lys Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr 
    370                 375                 380                 


Lys Val Phe Asn Gly Glu Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu 
385                 390                 395                 400 


His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met 
                405                 410                 415     


Gly Cys His Gly Tyr Arg Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr 
            420                 425                 430         


Arg Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu 
        435                 440                 445             


His Thr Phe His 
    450         


<210>  4
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu 
            100                 105                 110         


Lys Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met 
        115                 120                 125             


Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln 
    130                 135                 140                 


Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys 
145                 150                 155                 160 


Leu His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Ser Tyr Ala 
                165                 170                 175     


Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val 
            180                 185                 190         


Gly Lys Pro His Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Arg 
        195                 200                 205             


Ser Ser Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Asn 
    210                 215                 220                 


Val Ser Met Glu Ala Ala Gly Gln Val Met Ser His His Asp Ser 
225                 230                 235                 


<210>  5
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu 
1               5                   10                  15      


Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser 
            20                  25                  30          


Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn 
        35                  40                  45              


Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro 
    50                  55                  60                  


Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu 
65                  70                  75                  80  


Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val 
                85                  90                  95      


Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Glu Arg 
            100                 105                 110         


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
        115                 120                 125             


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
    130                 135                 140                 


Pro Phe Cys Ser Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
145                 150                 155                 160 


Leu Arg Thr His Ser Val Pro Pro Met Glu Asp Cys Lys Glu Gln Glu 
                165                 170                 175     


Pro Ile Met Asp Asn Asn Ile Ser Leu Val Pro Phe Glu Arg Pro Ala 
            180                 185                 190         


Val Ile Glu Lys Leu Thr Gly Asn Met Gly Lys Arg Lys Ser Ser Thr 
        195                 200                 205             


Pro Gln Lys Phe Val Gly Glu Lys Leu Met Arg Phe Ser Tyr Pro Asp 
    210                 215                 220                 


Ile His Phe Asp Met Asn Leu Thr Tyr Glu Lys Glu Ala Glu Leu Met 
225                 230                 235                 240 


Gln Ser His Met Met Asp Gln Ala Ile Asn Asn Ala Ile Thr Tyr Leu 
                245                 250                 255     


Gly Ala Glu Ala Leu His Pro Leu Met Gln His Pro Pro Ser Thr Ile 
            260                 265                 270         


Ala Glu Val Ala Pro Val Ile Ser Ser Ala Tyr Ser Gln Val Tyr His 
        275                 280                 285             


Pro Asn Arg Ile Glu Arg Pro Ile Ser Arg Glu Thr Ala Asp Ser His 
    290                 295                 300                 


Glu Asn Asn Met Asp Gly Pro Ile Ser Leu Ile Arg Pro Lys Ser Arg 
305                 310                 315                 320 


Pro Gln Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Leu Asp Ser Thr 
                325                 330                 335     


Asp Ser Glu Ser Ser His Asp Asp His Gln Ser Tyr Gln Gly His Pro 
            340                 345                 350         


Ala Leu Asn Pro Lys Arg Lys Gln Ser Pro Ala Tyr Met Lys Glu Asp 
        355                 360                 365             


Val Lys Ala Leu Asp Thr Thr Lys Ala Pro Lys Gly Ser Leu Lys Asp 
    370                 375                 380                 


Ile Tyr Lys Val Phe Asn Gly Glu Gly Glu Gln Ile Arg Ala Phe Lys 
385                 390                 395                 400 


Cys Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile 
                405                 410                 415     


His Met Gly Cys His Gly Tyr Arg Asp Pro Leu Glu Cys Asn Ile Cys 
            420                 425                 430         


Gly Tyr Arg Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg 
        435                 440                 445             


Gly Glu His Thr Phe His 
    450                 


<210>  6
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His 
            20              


<210>  7
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  7

Met His Thr Pro Pro Ala Leu Pro Arg Arg Phe Gln Gly Gly Gly Arg 
1               5                   10                  15      


Val Arg Thr Pro Gly Ser His Arg Gln Gly Lys Asp Asn Leu Glu Arg 
            20                  25                  30          


Asp Pro Ser Gly Gly Cys Val Pro Asp Phe Leu Pro Gln Ala Gln Asp 
        35                  40                  45              


Ser Asn His Phe Ile Met Glu Ser Leu Phe Cys Glu Ser Ser Gly Asp 
    50                  55                  60                  


Ser Ser Leu Glu Lys Glu Phe Leu Gly Ala Pro Val Gly Pro Ser Val 
65                  70                  75                  80  


Ser Thr Pro Asn Ser Gln His Ser Ser Pro Ser Arg Ser Leu Ser Ala 
                85                  90                  95      


Asn Ser Ile Lys Val Glu Met Tyr Ser Asp Glu Glu Ser Ser Arg Leu 
            100                 105                 110         


Leu Gly Pro Asp Glu Arg Leu Leu Glu Lys Asp Asp Ser Val Ile Val 
        115                 120                 125             


Glu Asp Ser Leu Ser Glu Pro Leu Gly Tyr Cys Asp Gly Ser Gly Pro 
    130                 135                 140                 


Glu Pro His Ser Pro Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu Lys 
145                 150                 155                 160 


Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met Val 
                165                 170                 175     


His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln Cys 
            180                 185                 190         


Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu 
        195                 200                 205             


His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Asn Tyr Ala Cys 
    210                 215                 220                 


Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val Ser 
225                 230                 235                 240 


Ser Pro Thr Val Gly Lys Pro Tyr Lys Cys Asn Tyr Cys Gly Arg Ser 
                245                 250                 255     


Tyr Lys Gln Gln Ser Thr Leu Glu Glu His Lys Glu Arg Cys His Asn 
            260                 265                 270         


Tyr Leu Gln Ser Leu Ser Thr Glu Ala Gln Ala Leu Ala Gly Gln Pro 
        275                 280                 285             


Gly Asp Glu Ile Arg Asp Leu Glu Met Val Pro Asp Ser Met Leu His 
    290                 295                 300                 


Ser Ser Ser Glu Arg Pro Thr Phe Ile Asp Arg Leu Ala Asn Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Lys Arg Ser Thr Pro Gln Lys Phe Val Gly Glu Lys Gln 
                325                 330                 335     


Met Arg Phe Ser Leu Ser Asp Leu Pro Tyr Asp Val Asn Ser Gly Gly 
            340                 345                 350         


Tyr Glu Lys Asp Val Glu Leu Val Ala His His Ser Leu Glu Pro Gly 
        355                 360                 365             


Phe Gly Ser Ser Leu Ala Phe Val Gly Ala Glu His Leu Arg Pro Leu 
    370                 375                 380                 


Arg Leu Pro Pro Thr Asn Cys Ile Ser Glu Leu Thr Pro Val Ile Ser 
385                 390                 395                 400 


Ser Val Tyr Thr Gln Met Gln Pro Leu Pro Gly Arg Leu Glu Leu Pro 
                405                 410                 415     


Gly Ser Arg Glu Ala Gly Glu Gly Pro Glu Asp Leu Ala Asp Gly Gly 
            420                 425                 430         


Pro Leu Leu Tyr Arg Pro Arg Gly Pro Leu Thr Asp Pro Gly Ala Ser 
        435                 440                 445             


Pro Ser Asn Gly Cys Gln Asp Ser Thr Asp Thr Glu Ser Asn His Glu 
    450                 455                 460                 


Asp Arg Val Ala Gly Val Val Ser Leu Pro Gln Gly Pro Pro Pro Gln 
465                 470                 475                 480 


Pro Pro Pro Thr Ile Val Val Gly Arg His Ser Pro Ala Tyr Ala Lys 
                485                 490                 495     


Glu Asp Pro Lys Pro Gln Glu Gly Leu Leu Arg Gly Thr Pro Gly Pro 
            500                 505                 510         


Ser Lys Glu Val Leu Arg Val Val Gly Glu Ser Gly Glu Pro Val Lys 
        515                 520                 525             


Ala Phe Lys Cys Glu His Cys Arg Ile Leu Phe Leu Asp His Val Met 
    530                 535                 540                 


Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys 
545                 550                 555                 560 


Asn Ile Cys Gly Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His 
                565                 570                 575     


Ile Val Arg Gly Glu His Lys Val Gly 
            580                 585 


<210>  8
<211>  544
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Ser Arg Tyr Leu Gln Leu Gln Leu Tyr Leu Pro Ser Cys Ser 
1               5                   10                  15      


Leu Leu Gln Gly Ser Gly Asp Ser Ser Leu Glu Lys Glu Phe Leu Gly 
            20                  25                  30          


Ala Pro Val Gly Pro Ser Val Ser Thr Pro Asn Ser Gln His Ser Ser 
        35                  40                  45              


Pro Ser Arg Ser Leu Ser Ala Asn Ser Ile Lys Val Glu Met Tyr Ser 
    50                  55                  60                  


Asp Glu Glu Ser Ser Arg Leu Leu Gly Pro Asp Glu Arg Leu Leu Glu 
65                  70                  75                  80  


Lys Asp Asp Ser Val Ile Val Glu Asp Ser Leu Ser Glu Pro Leu Gly 
                85                  90                  95      


Tyr Cys Asp Gly Ser Gly Pro Glu Pro His Ser Pro Gly Gly Ile Arg 
            100                 105                 110         


Leu Pro Asn Gly Lys Leu Lys Cys Asp Val Cys Gly Met Val Cys Ile 
        115                 120                 125             


Gly Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg 
    130                 135                 140                 


Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys 
                165                 170                 175     


Pro Phe Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His 
            180                 185                 190         


Leu Arg Thr His Ser Val Ser Ser Pro Thr Val Gly Lys Pro Tyr Lys 
        195                 200                 205             


Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Gln Ser Thr Leu Glu Glu 
    210                 215                 220                 


His Lys Glu Arg Cys His Asn Tyr Leu Gln Ser Leu Ser Thr Glu Ala 
225                 230                 235                 240 


Gln Ala Leu Ala Gly Gln Pro Gly Asp Glu Ile Arg Asp Leu Glu Met 
                245                 250                 255     


Val Pro Asp Ser Met Leu His Ser Ser Ser Glu Arg Pro Thr Phe Ile 
            260                 265                 270         


Asp Arg Leu Ala Asn Ser Leu Thr Lys Arg Lys Arg Ser Thr Pro Gln 
        275                 280                 285             


Lys Phe Val Gly Glu Lys Gln Met Arg Phe Ser Leu Ser Asp Leu Pro 
    290                 295                 300                 


Tyr Asp Val Asn Ser Gly Gly Tyr Glu Lys Asp Val Glu Leu Val Ala 
305                 310                 315                 320 


His His Ser Leu Glu Pro Gly Phe Gly Ser Ser Leu Ala Phe Val Gly 
                325                 330                 335     


Ala Glu His Leu Arg Pro Leu Arg Leu Pro Pro Thr Asn Cys Ile Ser 
            340                 345                 350         


Glu Leu Thr Pro Val Ile Ser Ser Val Tyr Thr Gln Met Gln Pro Leu 
        355                 360                 365             


Pro Gly Arg Leu Glu Leu Pro Gly Ser Arg Glu Ala Gly Glu Gly Pro 
    370                 375                 380                 


Glu Asp Leu Ala Asp Gly Gly Pro Leu Leu Tyr Arg Pro Arg Gly Pro 
385                 390                 395                 400 


Leu Thr Asp Pro Gly Ala Ser Pro Ser Asn Gly Cys Gln Asp Ser Thr 
                405                 410                 415     


Asp Thr Glu Ser Asn His Glu Asp Arg Val Ala Gly Val Val Ser Leu 
            420                 425                 430         


Pro Gln Gly Pro Pro Pro Gln Pro Pro Pro Thr Ile Val Val Gly Arg 
        435                 440                 445             


His Ser Pro Ala Tyr Ala Lys Glu Asp Pro Lys Pro Gln Glu Gly Leu 
    450                 455                 460                 


Leu Arg Gly Thr Pro Gly Pro Ser Lys Glu Val Leu Arg Val Val Gly 
465                 470                 475                 480 


Glu Ser Gly Glu Pro Val Lys Ala Phe Lys Cys Glu His Cys Arg Ile 
                485                 490                 495     


Leu Phe Leu Asp His Val Met Phe Thr Ile His Met Gly Cys His Gly 
            500                 505                 510         


Phe Arg Asp Pro Phe Glu Cys Asn Ile Cys Gly Tyr His Ser Gln Asp 
        515                 520                 525             


Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu His Lys Val Gly 
    530                 535                 540                 


