                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
 
<120>  CD28H DOMAIN-CONTAINING CHIMERIC ANTIGEN RECEPTORS AND METHODS OF
        USE

<130>  4239-104206-01

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28H(FL)-TCRzeta(CD)

<400>  1
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga ttcctcttcg tgctgctggg ggtgggaagc      480

atgggtgtgg ctgcgatcgt gtggggtgcc tggttctggg gccgccgcag ctgccagcaa      540

agggactcag gtaacagccc aggaaatgca ttctacagca acgtcctata ccggccccgg      600

ggggccccaa agaagagtga ggactgctct ggagagggga aggaccagag gggccagagc      660

atttattcaa cctccttccc gcaaccggcc ccccgccagc cgcacctggc gtcaagaccc      720

tgccccagcc cgagaccctg ccccagcccc aggcccggcc accccgtctc tatggtcagg      780

gtctctccta gaccaagccc cacccagcag ccgaggccaa aagggttccc caaagtggga      840

gaggagagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac      900

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga      960

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1020

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1080

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1140

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1185


<210>  2
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28H(FL)-TCRzeta(CD)

<400>  2

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu Arg Val Lys Phe Ser Arg 
        275                 280                 285             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    290                 295                 300                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
305                 310                 315                 320 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
                325                 330                 335     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            340                 345                 350         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        355                 360                 365             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    370                 375                 380                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395 


<210>  3
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28H(EC-TM)-TCRzeta(CD)

<400>  3
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga ttcctcttcg tgctgctggg ggtgggaagc      480

atgggtgtgg ctgcgatcgt gtggggtgcc tggagagtga agttcagcag gagcgcagac      540

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      600

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      660

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      720

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc      780

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc      840

ctgccccctc gc                                                          852


<210>  4
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28H(EC-TM)-TCRzeta(CD)

<400>  4

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Arg Val Lys Phe Ser 
                165                 170                 175     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            180                 185                 190         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        195                 200                 205             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys 
    210                 215                 220                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
225                 230                 235                 240 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                245                 250                 255     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            260                 265                 270         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280                 


<210>  5
<211>  1545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28H.CAR2

<400>  5
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga ttcctcttcg tgctgctggg ggtgggaagc      480

atgggtgtgg ctgcgatcgt gtggggtgcc tggttctggg gccgccgcag ctgccagcaa      540

agggactcag gtaacagccc aggaaatgca ttctacagca acgtcctata ccggccccgg      600

ggggccccaa agaagagtga ggactgctct ggagagggga aggaccagag gggccagagc      660

atttattcaa ccagtttccc tcaaccggct ccaagacaac cacatctcgc cagtcggcct      720

tgtccgtccc ctagaccctg ccccagtccc aggcccggcc accccgtctc tatggtcagg      780

gtctctccta gaccaagccc cacccagcag ccgaggccaa aagggttccc caaagtggga      840

gaggagtgga ggagaaagag gaaggagaag cagtcagaga ccagtcccaa ggaatttttg      900

acaatttacg aagatgtcaa ggatctgaaa accaggagaa atcacgagca ggagcagact      960

tttcctggag gggggagcac catctactct atgatccagt cccagtcttc tgctcccacg     1020

tcacaagaac ctgcatatac attatattca ttaattcagc cttccaggaa gtctggatcc     1080

aggaagagga accacagccc ttccttcaat agcactatct atgaagtgat tggaaagagt     1140

caacctaaag cccagaaccc tgctcgattg agccgcaaag agctggagaa ctttgatgtt     1200

tattccagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1260

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1320

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1380

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1440

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1500

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1545


<210>  6
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28H.CAR2

<400>  6

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu Trp Arg Arg Lys Arg Lys 
        275                 280                 285             


Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu 
    290                 295                 300                 


Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr 
305                 310                 315                 320 


Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser 
                325                 330                 335     


Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile 
            340                 345                 350         


Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser 
        355                 360                 365             


Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala 
    370                 375                 380                 


Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val 
385                 390                 395                 400 


Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                405                 410                 415     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            420                 425                 430         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        435                 440                 445             


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    450                 455                 460                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
465                 470                 475                 480 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                485                 490                 495     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            500                 505                 510         


Pro Pro Arg 
        515 


<210>  7
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28H.T-CAR

<400>  7
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga ttttgggtgc tggtggtggt tggtggagtc      480

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      540

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      600

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccaaacgg      660

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      720

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      960

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1020

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1080

acctacgacg cccttcacat gcaggccctg ccccctcgc                            1119


<210>  8
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28H.T-CAR

<400>  8

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Trp Val Leu Val Val Val Gly Gly Val 
145                 150                 155                 160 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                165                 170                 175     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
305                 310                 315                 320 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
                325                 330                 335     


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
            340                 345                 350         


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
        355                 360                 365             


Ala Leu Pro Pro Arg 
    370             


<210>  9
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28H.CAR3

<400>  9
atggggtccc cgggcatggt gctgggcctc ctggtgcaga tctgggccct gcaagaagcc       60

tcaagcctga gcgtgcagca ggggcccaac ttgctgcagg tgaggcaggg cagtcaggcg      120

accctggtct gccaggtgga ccaggccaca gcctgggaac ggctccgtgt taagtggaca      180

aaggatgggg ccatcctgtg tcaaccgtac atcaccaacg gcagcctcag cctgggggtc      240

tgcgggcccc agggacggct ctcctggcag gcacccagcc atctcaccct gcagctggac      300

cctgtgagcc tcaaccacag cggggcgtac gtgtgctggg cggccgtaga gattcctgag      360

ttggaggagg ctgagggcaa cataacaagg ctctttgtgg acccagatga ccccacacag      420

aacagaaacc ggatcgcaag cttcccagga ccattttttt tctgctgctt catcgctgta      480

gccatgggaa tccgtttcat tattatggta acatggagga gaaagaggaa ggagaagcag      540

tcagagacca gtcccaagga atttttgaca atttacgaag atgtcaagga tctgaaaacc      600

aggagaaatc acgagcagga gcagactttt cctggagggg ggagcaccat ctactctatg      660

atccagtccc agtcttctgc tcccacgtca caagaacctg catatacatt atattcatta      720

attcagcctt ccaggaagtc tggatccagg aagaggaacc acagcccttc cttcaatagc      780

actatctatg aagtgattgg aaagagtcaa cctaaagccc agaaccctgc tcgattgagc      840

cgcaaagagc tggagaactt tgatgtttat tccagagtga agttcagcag gagcgcagac      900

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      960

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1020

cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1080

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1140

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1200

ctgccccctc gc                                                         1212


<210>  10
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28H.CAR3

<400>  10

Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Pro Phe Phe Phe Cys Cys Phe Ile Ala Val 
145                 150                 155                 160 


Ala Met Gly Ile Arg Phe Ile Ile Met Val Thr Trp Arg Arg Lys Arg 
                165                 170                 175     


Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr 
            180                 185                 190         


Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln 
        195                 200                 205             


Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln 
    210                 215                 220                 


Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu 
225                 230                 235                 240 


Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro 
                245                 250                 255     


Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys 
            260                 265                 270         


Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp 
        275                 280                 285             


Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    290                 295                 300                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
305                 310                 315                 320 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                325                 330                 335     


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            340                 345                 350         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        355                 360                 365             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    370                 375                 380                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
385                 390                 395                 400 


Leu Pro Pro Arg 
                


<210>  11
<211>  2049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19.CAR2

<400>  11
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cctgagcaaa aacttatctc tgaagaggac ctcgatatac agatgacgca gacaacgtca      120

agtctttccg ccagcttggg agaccgagtg actatatctt gtagagcaag ccaggatatt      180

tctaagtatc ttaactggta ccaacaaaag cccgatggaa cggttaagct gcttatatac      240

cataccagta gactccactc cggcgtacca tcacggtttt ctggcagtgg ctccgggacc      300

gactattctt tgacgatctc taatctcgaa caagaggata ttgcaacata cttttgtcag      360

caaggcaata ccttgccata tacgtttggg ggcgggacaa aacttgagat aaccggcggc      420

ggtggttcag gcggtggcgg ttccggtggt gggggatcag aggttaagct tcaggaatcc      480

ggaccaggtt tggttgcccc cagccaatct ctcagcgtta catgcacggt ttcaggcgtc      540

agtctccccg attacggtgt aagttggatt cggcaacctc cgcgaaaggg tctggaatgg      600

ctgggggtta tttgggggag tgagacaact tattacaact ctgcacttaa gagtcggctt      660

accatcatca aggataattc aaaatcacaa gtattcctga agatgaactc attgcaaaca      720

gatgatacag ctatatacta ttgtgccaag cattactatt atggtggttc ttatgcaatg      780

gattactggg ggcaaggcac gtcagtgaca gtgagttcaa ccaccacccc tgcaccaaga      840

cctccaactc ctgccccaac tattgcaagt cagccacttt ctttgcgacc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttcctc      960

ttcgtgctgc tgggggtggg aagcatgggt gtggctgcga tcgtgtgggg tgcctggttc     1020

tggggccgcc gcagctgcca gcaaagggac tcaggtaaca gcccaggaaa tgcattctac     1080

agcaacgtcc tataccggcc ccggggggcc ccaaagaaga gtgaggactg ctctggagag     1140

gggaaggacc agaggggcca gagcatttat tcaaccagtt tccctcaacc ggctccaaga     1200

caaccacatc tcgccagtcg gccttgtccg tcccctagac cctgccccag tcccaggccc     1260

ggccaccccg tctctatggt cagggtctct cctagaccaa gccccaccca gcagccgagg     1320

ccaaaagggt tccccaaagt gggagaggag tggaggagaa agaggaagga gaagcagtca     1380

gagaccagtc ccaaggaatt tttgacaatt tacgaagatg tcaaggatct gaaaaccagg     1440

agaaatcacg agcaggagca gacttttcct ggagggggga gcaccatcta ctctatgatc     1500

cagtcccagt cttctgctcc cacgtcacaa gaacctgcat atacattata ttcattaatt     1560

cagccttcca ggaagtctgg atccaggaag aggaaccaca gcccttcctt caatagcact     1620

atctatgaag tgattggaaa gagtcaacct aaagcccaga accctgctcg attgagccgc     1680

aaagagctgg agaactttga tgtttattcc agagtgaagt tcagcaggag cgcagacgcc     1740

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1800

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgcag     1860

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1920

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1980

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     2040

ccccctcgc                                                             2049


<210>  12
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19.CAR2

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Leu 
305                 310                 315                 320 


Phe Val Leu Leu Gly Val Gly Ser Met Gly Val Ala Ala Ile Val Trp 
                325                 330                 335     


Gly Ala Trp Phe Trp Gly Arg Arg Ser Cys Gln Gln Arg Asp Ser Gly 
            340                 345                 350         


Asn Ser Pro Gly Asn Ala Phe Tyr Ser Asn Val Leu Tyr Arg Pro Arg 
        355                 360                 365             


Gly Ala Pro Lys Lys Ser Glu Asp Cys Ser Gly Glu Gly Lys Asp Gln 
    370                 375                 380                 


Arg Gly Gln Ser Ile Tyr Ser Thr Ser Phe Pro Gln Pro Ala Pro Arg 
385                 390                 395                 400 


Gln Pro His Leu Ala Ser Arg Pro Cys Pro Ser Pro Arg Pro Cys Pro 
                405                 410                 415     


Ser Pro Arg Pro Gly His Pro Val Ser Met Val Arg Val Ser Pro Arg 
            420                 425                 430         


Pro Ser Pro Thr Gln Gln Pro Arg Pro Lys Gly Phe Pro Lys Val Gly 
        435                 440                 445             


Glu Glu Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro 
    450                 455                 460                 


Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg 
465                 470                 475                 480 


Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile 
                485                 490                 495     


Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro 
            500                 505                 510         


Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser 
        515                 520                 525             


Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val 
    530                 535                 540                 


Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg 
545                 550                 555                 560 


Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser Arg Val Lys Phe Ser Arg 
                565                 570                 575     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            580                 585                 590         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        595                 600                 605             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
    610                 615                 620                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
625                 630                 635                 640 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                645                 650                 655     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            660                 665                 670         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680             


<210>  13
<211>  1623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19-T-CAR

<400>  13
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cctgagcaaa aacttatctc tgaagaggac ctcgatatac agatgacgca gacaacgtca      120

agtctttccg ccagcttggg agaccgagtg actatatctt gtagagcaag ccaggatatt      180

tctaagtatc ttaactggta ccaacaaaag cccgatggaa cggttaagct gcttatatac      240

cataccagta gactccactc cggcgtacca tcacggtttt ctggcagtgg ctccgggacc      300

gactattctt tgacgatctc taatctcgaa caagaggata ttgcaacata cttttgtcag      360

caaggcaata ccttgccata tacgtttggg ggcgggacaa aacttgagat aaccggcggc      420

ggtggttcag gcggtggcgg ttccggtggt gggggatcag aggttaagct tcaggaatcc      480

ggaccaggtt tggttgcccc cagccaatct ctcagcgtta catgcacggt ttcaggcgtc      540

agtctccccg attacggtgt aagttggatt cggcaacctc cgcgaaaggg tctggaatgg      600

ctgggggtta tttgggggag tgagacaact tattacaact ctgcacttaa gagtcggctt      660

accatcatca aggataattc aaaatcacaa gtattcctga agatgaactc attgcaaaca      720

gatgatacag ctatatacta ttgtgccaag cattactatt atggtggttc ttatgcaatg      780

gattactggg ggcaaggcac gtcagtgaca gtgagttcaa ccaccacccc tgcaccaaga      840

cctccaactc ctgccccaac tattgcaagt cagccacttt ctttgcgacc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttttgg      960

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1020

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1080

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1140

ttcgcagcct atcgctccaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1200

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1260

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1320

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1380

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg     1440

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1500

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1560

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1620

cgc                                                                   1623


<210>  14
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19.T-CAR

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
385                 390                 395                 400 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                405                 410                 415     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            420                 425                 430         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        435                 440                 445             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    450                 455                 460                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
465                 470                 475                 480 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                485                 490                 495     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            500                 505                 510         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        515                 520                 525             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540     


<210>  15
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19.CAR4

<400>  15
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cctgagcaaa aacttatctc tgaagaggac ctcgatatac agatgacgca gacaacgtca      120

agtctttccg ccagcttggg agaccgagtg actatatctt gtagagcaag ccaggatatt      180

tctaagtatc ttaactggta ccaacaaaag cccgatggaa cggttaagct gcttatatac      240

cataccagta gactccactc cggcgtacca tcacggtttt ctggcagtgg ctccgggacc      300

gactattctt tgacgatctc taatctcgaa caagaggata ttgcaacata cttttgtcag      360

caaggcaata ccttgccata tacgtttggg ggcgggacaa aacttgagat aaccggcggc      420

ggtggttcag gcggtggcgg ttccggtggt gggggatcag aggttaagct tcaggaatcc      480

ggaccaggtt tggttgcccc cagccaatct ctcagcgtta catgcacggt ttcaggcgtc      540

agtctccccg attacggtgt aagttggatt cggcaacctc cgcgaaaggg tctggaatgg      600

ctgggggtta tttgggggag tgagacaact tattacaact ctgcacttaa gagtcggctt      660

accatcatca aggataattc aaaatcacaa gtattcctga agatgaactc attgcaaaca      720

gatgatacag ctatatacta ttgtgccaag cattactatt atggtggttc ttatgcaatg      780

gattactggg ggcaaggcac gtcagtgaca gtgagttcaa ccaccacccc tgcaccaaga      840

cctccaactc ctgccccaac tattgcaagt cagccacttt ctttgcgacc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttcctc      960

ttcgtgctgc tgggggtggg aagcatgggt gtggctgcga tcgtgtgggg tgcctggttc     1020

tggggccgcc gcagctgcca gcaaagggac tcaggtaaca gcccaggaaa tgcattctac     1080

agcaacgtcc tataccggcc ccggggggcc ccaaagaaga gtgaggactg ctctggagag     1140

gggaaggacc agaggggcca gagcatttat tcaaccagtt tccctcaacc ggctccaaga     1200

caaccacatc tcgccagtcg gccttgtccg tcccctagac cctgccccag tcccaggccc     1260

ggccaccccg tctctatggt cagggtctct cctagaccaa gccccaccca gcagccgagg     1320

ccaaaagggt tccccaaagt gggagaggag agagtgaagt tcagcaggag cgcagacgcc     1380

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1440

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgcag     1500

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1560

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1620

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1680

ccccctcgc                                                             1689


<210>  16
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19.CAR4

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Leu 
305                 310                 315                 320 


Phe Val Leu Leu Gly Val Gly Ser Met Gly Val Ala Ala Ile Val Trp 
                325                 330                 335     


Gly Ala Trp Phe Trp Gly Arg Arg Ser Cys Gln Gln Arg Asp Ser Gly 
            340                 345                 350         


Asn Ser Pro Gly Asn Ala Phe Tyr Ser Asn Val Leu Tyr Arg Pro Arg 
        355                 360                 365             


Gly Ala Pro Lys Lys Ser Glu Asp Cys Ser Gly Glu Gly Lys Asp Gln 
    370                 375                 380                 


Arg Gly Gln Ser Ile Tyr Ser Thr Ser Phe Pro Gln Pro Ala Pro Arg 
385                 390                 395                 400 


Gln Pro His Leu Ala Ser Arg Pro Cys Pro Ser Pro Arg Pro Cys Pro 
                405                 410                 415     


Ser Pro Arg Pro Gly His Pro Val Ser Met Val Arg Val Ser Pro Arg 
            420                 425                 430         


Pro Ser Pro Thr Gln Gln Pro Arg Pro Lys Gly Phe Pro Lys Val Gly 
        435                 440                 445             


Glu Glu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    450                 455                 460                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
465                 470                 475                 480 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                485                 490                 495     


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            500                 505                 510         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        515                 520                 525             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    530                 535                 540                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
545                 550                 555                 560 


Pro Pro Arg 
            


<210>  17
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19.CAR5

<400>  17
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cctgagcaaa aacttatctc tgaagaggac ctcgatatac agatgacgca gacaacgtca      120

agtctttccg ccagcttggg agaccgagtg actatatctt gtagagcaag ccaggatatt      180

tctaagtatc ttaactggta ccaacaaaag cccgatggaa cggttaagct gcttatatac      240

cataccagta gactccactc cggcgtacca tcacggtttt ctggcagtgg ctccgggacc      300

gactattctt tgacgatctc taatctcgaa caagaggata ttgcaacata cttttgtcag      360

caaggcaata ccttgccata tacgtttggg ggcgggacaa aacttgagat aaccggcggc      420

ggtggttcag gcggtggcgg ttccggtggt gggggatcag aggttaagct tcaggaatcc      480

ggaccaggtt tggttgcccc cagccaatct ctcagcgtta catgcacggt ttcaggcgtc      540

agtctccccg attacggtgt aagttggatt cggcaacctc cgcgaaaggg tctggaatgg      600

ctgggggtta tttgggggag tgagacaact tattacaact ctgcacttaa gagtcggctt      660

accatcatca aggataattc aaaatcacaa gtattcctga agatgaactc attgcaaaca      720

gatgatacag ctatatacta ttgtgccaag cattactatt atggtggttc ttatgcaatg      780

gattactggg ggcaaggcac gtcagtgaca gtgagttcaa ccaccacccc tgcaccaaga      840

cctccaactc ctgccccaac tattgcaagt cagccacttt ctttgcgacc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttttgg      960

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1020

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1080

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1140

ttcgcagcct atcgctccag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag     1200

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1260

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgcagag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        1497


<210>  18
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19.CAR5

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  19
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19.CAR6

<400>  19
atggcgctcc ctgtcaccgc actgcttctt ccgctggcac tgctgctgca cgctgcacgg       60

cctgagcaaa aacttatctc tgaagaggac ctcgatatac agatgacgca gacaacgtca      120

agtctttccg ccagcttggg agaccgagtg actatatctt gtagagcaag ccaggatatt      180

tctaagtatc ttaactggta ccaacaaaag cccgatggaa cggttaagct gcttatatac      240

cataccagta gactccactc cggcgtacca tcacggtttt ctggcagtgg ctccgggacc      300

gactattctt tgacgatctc taatctcgaa caagaggata ttgcaacata cttttgtcag      360

caaggcaata ccttgccata tacgtttggg ggcgggacaa aacttgagat aaccggcggc      420

ggtggttcag gcggtggcgg ttccggtggt gggggatcag aggttaagct tcaggaatcc      480

ggaccaggtt tggttgcccc cagccaatct ctcagcgtta catgcacggt ttcaggcgtc      540

agtctccccg attacggtgt aagttggatt cggcaacctc cgcgaaaggg tctggaatgg      600

ctgggggtta tttgggggag tgagacaact tattacaact ctgcacttaa gagtcggctt      660

accatcatca aggataattc aaaatcacaa gtattcctga agatgaactc attgcaaaca      720

gatgatacag ctatatacta ttgtgccaag cattactatt atggtggttc ttatgcaatg      780

gattactggg ggcaaggcac gtcagtgaca gtgagttcaa ccaccacccc tgcaccaaga      840

cctccaactc ctgccccaac tattgcaagt cagccacttt ctttgcgacc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatttcctc      960

ttcgtgctgc tgggggtggg aagcatgggt gtggctgcga tcgtgtgggg tgcctggaga     1020

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1080

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1140

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat     1200

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1260

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1320

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1356


<210>  20
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19.CAR6

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Leu 
305                 310                 315                 320 


Phe Val Leu Leu Gly Val Gly Ser Met Gly Val Ala Ala Ile Val Trp 
                325                 330                 335     


Gly Ala Trp Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg 
    450         


<210>  21
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  22
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Ser Thr Leu Pro Ala Leu Leu Cys Val Gly Leu Cys Leu Ser 
1               5                   10                  15      


Gln Arg Ile Ser Ala Gln Gln Gln Thr Leu Pro Lys Pro Phe Ile Trp 
            20                  25                  30          


Ala Glu Pro His Phe Met Val Pro Lys Glu Lys Gln Val Thr Ile Cys 
        35                  40                  45              


Cys Gln Gly Asn Tyr Gly Ala Val Glu Tyr Gln Leu His Phe Glu Gly 
    50                  55                  60                  


Ser Leu Phe Ala Val Asp Arg Pro Lys Pro Pro Glu Arg Ile Asn Lys 
65                  70                  75                  80  


Val Lys Phe Tyr Ile Pro Asp Met Asn Ser Arg Met Ala Gly Gln Tyr 
                85                  90                  95      


Ser Cys Ile Tyr Arg Val Gly Glu Leu Trp Ser Glu Pro Ser Asn Leu 
            100                 105                 110         


Leu Asp Leu Val Val Thr Glu Met Tyr Asp Thr Pro Thr Leu Ser Val 
        115                 120                 125             


His Pro Gly Pro Glu Val Ile Ser Gly Glu Lys Val Thr Phe Tyr Cys 
    130                 135                 140                 


Arg Leu Asp Thr Ala Thr Ser Met Phe Leu Leu Leu Lys Glu Gly Arg 
145                 150                 155                 160 


Ser Ser His Val Gln Arg Gly Tyr Gly Lys Val Gln Ala Glu Phe Pro 
                165                 170                 175     


Leu Gly Pro Val Thr Thr Ala His Arg Gly Thr Tyr Arg Cys Phe Gly 
            180                 185                 190         


Ser Tyr Asn Asn His Ala Trp Ser Phe Pro Ser Glu Pro Val Lys Leu 
        195                 200                 205             


Leu Val Thr Gly Asp Ile Glu Asn Thr Ser Leu Ala Pro Glu Asp Pro 
    210                 215                 220                 


Thr Phe Pro Ala Asp Thr Trp Gly Thr Tyr Leu Leu Thr Thr Glu Thr 
225                 230                 235                 240 


Gly Leu Gln Lys Asp His Ala Leu Trp Asp His Thr Ala Gln Asn Leu 
                245                 250                 255     


Leu Arg Met Gly Leu Ala Phe Leu Val Leu Val Ala Leu Val Trp Phe 
            260                 265                 270         


Leu Val Glu Asp Trp Leu Ser Arg Lys Arg Thr Arg Glu Arg Ala Ser 
        275                 280                 285             


Arg Ala Ser Thr Trp Glu Gly Arg Arg Arg Leu Asn Thr Gln Thr Leu 
    290                 295                 300                 


<210>  23
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  24
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala 
            20                  25                  30          


Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu 
        35                  40                  45              


Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile 
    50                  55                  60                  


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg 
65                  70                  75                  80  


Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met 
                85                  90                  95      


Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr 
            100                 105                 110         


Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val 
        115                 120                 125             


Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
    130                 135                 140                 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
145                 150                 155                 160 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
                165                 170                 175     


Gln Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala 
            180                 185                 190         


Leu Val Pro Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu 
        195                 200                 205             


Ser Ala Leu Leu Val Trp Trp Gly Asp Ile Trp Trp Lys Thr Met Met 
    210                 215                 220                 


Glu Leu Arg Ser Leu Asp Thr Gln Lys Ala Thr Cys His Leu Gln Gln 
225                 230                 235                 240 


Val Thr Asp Leu Pro Trp Thr Ser Val Ser Ser Pro Val Glu Arg Glu 
                245                 250                 255     


Ile Leu Tyr His Thr Val Ala Arg Thr Lys Ile Ser Asp Asp Asp Asp 
            260                 265                 270         


Glu His Thr Leu 
        275     


<210>  25
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Leu Met Val Ile Ile Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Gln Glu Gly Val His Arg Lys Pro Ser Phe Leu 
            20                  25                  30          


Ala Leu Pro Gly His Leu Val Lys Ser Glu Glu Thr Val Ile Leu Gln 
        35                  40                  45              


Cys Trp Ser Asp Val Met Phe Glu His Phe Leu Leu His Arg Glu Gly 
    50                  55                  60                  


Lys Phe Asn Asn Thr Leu His Leu Ile Gly Glu His His Asp Gly Val 
65                  70                  75                  80  


Ser Lys Ala Asn Phe Ser Ile Gly Pro Met Met Pro Val Leu Ala Gly 
                85                  90                  95      


Thr Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser 
            100                 105                 110         


Ala Pro Ser Asp Pro Leu Asp Met Val Ile Ile Gly Leu Tyr Glu Lys 
        115                 120                 125             


Pro Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn 
    130                 135                 140                 


Val Thr Leu Ser Cys Ser Ser Arg Ser Ser Tyr Asp Met Tyr His Leu 
145                 150                 155                 160 


Ser Arg Glu Gly Glu Ala His Glu Arg Arg Leu Pro Ala Val Arg Ser 
                165                 170                 175     


Ile Asn Gly Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His 
            180                 185                 190         


Gly Gly Thr Tyr Arg Cys Phe Gly Ser Phe Arg Asp Ala Pro Tyr Glu 
        195                 200                 205             


Trp Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro 
    210                 215                 220                 


Ser Asn Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Thr Gly Asn 
225                 230                 235                 240 


Pro Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Lys Ile Pro 
                245                 250                 255     


Phe Thr Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ser Asp Lys 
            260                 265                 270         


Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val 
        275                 280                 285             


Asn Ser Glu Asp Ser Asp Glu Gln Asp His Gln Glu Val Ser Tyr Ala 
    290                 295                 300                 


