                         SEQUENCE LISTING

<110>  Erasmus University Medical Center Rotterdam
 
<120>  Reporter system for radionuclide imaging

<130>  P125637PC00

<140>  PCT/NL2021/050200
<141>  2021-03-25

<150>  EP 20165617.0
<151>  2020-03-25

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  1

Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile 
1               5                   10                  15      


Ser Leu Ile Ile Leu Ile Met Leu 
            20                  


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile His Trp Trp Pro Ile Ser Phe Ile Gly Val Gly Leu Val Leu Leu 
1               5                   10                  15      


Ile Val Leu Ile 
            20  


<210>  4
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Ile Ile Gly Val Ser Val Leu Val Val Ser Val Val Ala Val Leu 
1               5                   10                  15      


Val Tyr Lys Phe Tyr Phe 
            20          


<210>  5
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  6
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile 
1               5                   10                  15      


Leu Leu Tyr Ala Met 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu 
            20      


<210>  8
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  8

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile 
            20              


<210>  9
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  10
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            20                  25              


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgK chain leader sequence

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr 
            


<210>  13
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  14
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met 
            20                  25  


<210>  15
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  16
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BM40 leader sequence

<400>  17

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secrecon leader sequence

<400>  18

Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


<210>  19
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 leader sequence

<400>  20

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA leader sequence

<400>  21

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  22
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  24
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin (HSA) leader sequence

<400>  25

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Ser Ser Ala Tyr Ser 
1               5                   10                  15      


<210>  26
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala 
            20                  


<210>  27
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HiBiT

<400>  27
gtgagcggct ggcggctgtt caagaagatt agc                                    33


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HiBiT

<400>  28

Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HiBiT + M

<400>  29

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10          


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep78

<400>  30

Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep79

<400>  31

Asn Val Thr Gly Tyr Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10              


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80

<400>  32

Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10          


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80+M

<400>  33

Met Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83+M

<400>  34

Met Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10              


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83

<400>  35

Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83*

<400>  36

Gly Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10          


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80+S*

<400>  37

Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Ala 
1               5                   10              


<210>  38
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80+S

<400>  38

Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10              


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80+NS*

<400>  39

Asn Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Ala 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80+NS

<400>  40

Asn Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10                  


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83+S

<400>  41

Ser Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83+S*

<400>  42

Ser Gly Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10              


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep86+S

<400>  43

Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10          


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep86+NS

<400>  44

Asn Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10              


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep78+S

<400>  45

Ser Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10                  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep78+NS

<400>  46

Asn Ser Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Asn 
1               5                   10                  15  


<210>  47
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LgBiT

<400>  47
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagt         477


<210>  48
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT

<400>  48

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
145                 150                 155                 


<210>  49
<211>  3865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector

<400>  49
ggcctaactg gccggtacct gagtctaaat gagtcttcgg acctcgcggg ggccgcttaa       60

gcggtggtta gggtttgtct gacgcggggg gagggggaag gaacgaaaca ctctcattcg      120

gaggcggctc ggggtttggt cttggtggcc acgggcacgc agaagagcgc cgcgatcctc      180

ttaagcaccc ccccgccctc cgtggaggcg ggggtttggt cggcgggtgg taactggcgg      240

gccgctgact cgggcgggtc gcgcgcccca gagtgtgacc ttttcggtct gctcgcagac      300

ccccgggcgg cgccgccgcg gcggcgacgg gctcgctggg tcctaggctc catggggacc      360

gtatacgtgg acaggctctg gagcatccgc acgactgcgg tgatattacc ggagaccttc      420

tgcgggacga gccgggtcac gcggctgacg cggagcgtcc gttgggcgac aaacaccagg      480

acggggcaca ggtacactat cttgtcaccc ggaggcgcga gggactgcag gagcttcagg      540

gagtggcgca gctgcttcat ccccgtggcc cgttgctcgc gtttgctggc ggtgtccccg      600

gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc cagcgtcttg      660

tcattggcga agtcgaacac gcagatgcag tcggggcggc gcggtcccag gtccacttcg      720

catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga cccgcttaaa      780

agcttggcaa tccggtactg ttggtaaagc caccagatct gctagcgatc gcctaagtgg      840

gagctcaggg gaattctggc tcgagcggtg gtggcgggag cggaggtgga gggtcgtcag      900

gtgtcttcac actcgaagat ttcgttgggg actgggaaca gacagccgcc tacaacctgg      960

accaagtcct tgaacaggga ggtgtgtcca gtttgctgca gaatctcgcc gtgtccgtaa     1020

ctccgatcca aaggattgtc cggagcggtg aaaatgccct gaagatcgac atccatgtca     1080

tcatcccgta tgaaggtctg agcgccgacc aaatggccca gatcgaagag gtgtttaagg     1140

tggtgtaccc tgtggatgat catcacttta aggtgatcct gccctatggc acactggtaa     1200

tcgacggggt tacgccgaac atgctgaact atttcggacg gccgtatgaa ggcatcgccg     1260

tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac aaaattatcg     1320

acgagcgcct gatcaccccc gacggctcca tgctgttccg agtaaccatc aacagctaat     1380

ctagagtcgg ggcggccggc cgcttcgagc agacatgata agatacattg atgagtttgg     1440

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     1500

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     1560

ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta     1620

caaatgtggt aaaatcgata aggatccgtc gaccgatgcc cttgagagcc ttcaacccag     1680

tcagctcctt ccggtgggcg cggggcatga ctatcgtcgc cgcacttatg actgtcttct     1740

ttatcatgca actcgtagga caggtgccgg cagcgctctt ccgcttcctc gctcactgac     1800

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     1860

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     1920

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     1980

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     2040

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     2100

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     2160

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     2220

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     2280

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     2340

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     2400

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     2460

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     2520

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     2580

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     2640

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     2700

taaacttggt ctgacagcgg ccgcaaatgc taaaccactg cagtggttac cagtgcttga     2760

tcagtgaggc accgatctca gcgatctgcc tatttcgttc gtccatagtg gcctgactcc     2820

ccgtcgtgta gatcactacg attcgtgagg gcttaccatc aggccccagc gcagcaatga     2880

tgccgcgaga gccgcgttca ccggcccccg atttgtcagc aatgaaccag ccagcaggga     2940

gggccgagcg aagaagtggt cctgctactt tgtccgcctc catccagtct atgagctgct     3000

gtcgtgatgc tagagtaaga agttcgccag tgagtagttt ccgaagagtt gtggccattg     3060

ctactggcat cgtggtatca cgctcgtcgt tcggtatggc ttcgttcaac tctggttccc     3120

agcggtcaag ccgggtcaca tgatcaccca tattatgaag aaatgcagtc agctccttag     3180

ggcctccgat cgttgtcaga agtaagttgg ccgcggtgtt gtcgctcatg gtaatggcag     3240

cactacacaa ttctcttacc gtcatgccat ccgtaagatg cttttccgtg accggcgagt     3300

actcaaccaa gtcgttttgt gagtagtgta tacggcgacc aagctgctct tgcccggcgt     3360

ctatacggga caacaccgcg ccacatagca gtactttgaa agtgctcatc atcgggaatc     3420

gttcttcggg gcggaaagac tcaaggatct tgccgctatt gagatccagt tcgatatagc     3480

ccactcttgc acccagttga tcttcagcat cttttacttt caccagcgtt tcggggtgtg     3540

caaaaacagg caagcaaaat gccgcaaaga agggaatgag tgcgacacga aaatgttgga     3600

tgctcatact cgtccttttt caatattatt gaagcattta tcagggttac tagtacgtct     3660

ctcaaggata agtaagtaat attaaggtac gggaggtatt ggacaggccg caataaaata     3720

tctttatttt cattacatct gtgtgttggt tttttgtgtg aatcgatagt actaacatac     3780

gctctccatc aaaacaaaac gaaacaaaac aaactagcaa aataggctgt ccccagtgca     3840

agtgcaggtg ccagaacatt tctct                                           3865


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fmoc protected sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Ser(tBu)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Trp(Boc)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Arg(Pbf)

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Lys(Boc)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Ser(tBu)

<400>  50

Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10      


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High affinity peptide

<400>  51

Thr Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
1               5                   10                  15      


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep80*

<400>  52

Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser Ala 
1               5                   10          


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83+NS

<400>  53

Asn Ser Asn Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLpep83+NS*

<400>  54

Asn Ser Gly Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10                  


