                         SEQUENCE LISTING

<110>  CollPlant Ltd.
       ORR, Nadav
       STERN, Miriam
       ZARKA, Revital
 
<120>  COLLAGEN-BASED FORMULATIONS USABLE AS SOFT TISSUE FILLERS AND/OR 
       IMPLANTS

<130>  86700

<150>  US 62/992,998
<151>  2020-03-22

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  4662
<212>  DNA
<213>  Artificial Sequence - collagen alpha chain 1

<220>
<223>  "Synthetic sequence containing the coding regions of the vacuolar
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Collagen alpha 1(I) chain and 
       flanking regions"

<400>  1
gcgatgcatg taatgtcatg agccacatga tccaatggcc acaggaacgt aagaatgtag       60

atagatttga ttttgtccgt tagatagcaa acaacattat aaaaggtgtg tatcaatacg      120

aactaattca ctcattggat tcatagaagt ccattcctcc taagtatcta aaccatggct      180

cacgctcgtg ttctcctcct cgctctcgct gttttggcaa cagctgctgt ggctgtggct      240

tctagttctt cttttgctga ttcaaaccct attagacctg ttactgatag agcagcttcc      300

actttggctc aattgcaaga ggagggccag gttgagggcc aagatgagga tatccctcca      360

attacatgcg tgcaaaatgg cttgcgttac cacgataggg atgtgtggaa acctgaacct      420

tgtcgtatct gtgtgtgtga taacggcaag gtgctctgcg atgatgttat ctgcgatgag      480

acaaaaaatt gccctggcgc tgaagttcct gagggcgagt gttgccctgt gtgccctgat      540

ggttccgagt ccccaactga tcaggaaact actggcgtgg agggcccaaa aggagatact      600

ggtccacgtg gtcctagggg tccagcaggt cctccaggta gagatggtat tccaggccag      660

cctggattgc caggaccacc aggcccacct ggcccaccag gacctcctgg tcttggtgga      720

aatttcgctc cacaactctc ttatggctat gatgagaagt caacaggtgg tatttccgtt      780

ccaggtccta tgggaccatc cggaccaaga ggtctcccag gtcctccagg tgctcctgga      840

cctcaaggct ttcaaggacc tccaggcgaa ccaggagaac caggcgcttc tggaccaatg      900

ggcccaaggg gaccacctgg cccaccagga aaaaatggcg atgatggcga agctggaaag      960

cctggtcgtc ctggagagag aggtcctcct ggcccacagg gtgcaagagg cttgccagga     1020

actgctggct tgcctggaat gaagggacat aggggcttct ccggcctcga tggcgctaag     1080

ggtgatgctg gccctgctgg accaaagggc gagccaggtt cccctggaga aaacggtgct     1140

cctggacaaa tgggtcctcg tggacttcca ggagaaaggg gtcgtccagg cgctccagga     1200

ccagcaggtg ctaggggaaa cgatggtgca acaggcgctg ctggccctcc tggcccaact     1260

ggtcctgctg gccctccagg attcccaggc gcagttggag ctaaaggaga agcaggacca     1320

cagggcccta ggggttctga aggacctcag ggtgttagag gtgaaccagg tcctccaggc     1380

ccagctggag cagctggtcc agcaggaaat ccaggtgctg atggtcaacc tggagctaag     1440

ggcgctaatg gcgcaccagg tatcgcaggc gcaccaggtt ttcctggcgc tagaggccca     1500

agtggtcctc aaggaccagg tggaccacca ggtccaaaag gcaattctgg cgaacctggc     1560

gctccaggtt ctaaaggaga tactggtgct aaaggcgaac caggacctgt tggtgttcag     1620

ggtcctcctg gtcctgctgg agaagaagga aaaagaggtg ctcgtggaga accaggacca     1680

actggacttc ctggacctcc tggtgaacgt ggcggacctg gctcaagggg tttccctgga     1740

gctgatggag tggcaggtcc aaaaggccct gctggagaga gaggttcacc aggtccagct     1800

ggtcctaagg gctcccctgg tgaagcaggt agaccaggcg aagcaggatt gccaggcgca     1860

aagggattga caggctctcc tggtagtcct ggcccagatg gaaaaacagg cccaccaggt     1920

ccagcaggac aagatggacg tccaggccca ccaggtcctc ctggagcaag gggacaagct     1980

ggcgttatgg gttttccagg acctaaaggt gctgctggag agccaggaaa ggcaggtgaa     2040

agaggagttc ctggtccacc aggagcagtg ggtcctgctg gcaaagatgg tgaagctgga     2100

gcacagggcc ctccaggccc tgctggccca gctggcgaac gtggagaaca aggcccagct     2160

ggtagtccag gatttcaagg attgcctggc cctgctggcc ctccaggaga agcaggaaaa     2220

cctggagaac aaggagttcc tggtgatttg ggagcacctg gaccttcagg agcacgtggt     2280

gaaagaggct tccctggcga gaggggtgtt caaggtccac caggtccagc aggacctaga     2340

ggtgctaatg gcgctcctgg caacgatgga gcaaaaggtg atgctggtgc tcctggcgca     2400

cctggaagtc agggtgctcc tggattgcaa ggaatgcctg gagagagggg tgctgctggc     2460

ttgccaggcc caaagggcga taggggtgat gctggaccaa aaggtgctga tggatcccca     2520

ggaaaagatg gagttcgtgg tcttactggc ccaatcggac ctccaggccc tgctggcgct     2580

ccaggtgata agggcgaaag tggcccaagt ggacctgctg gacctactgg tgctagaggt     2640

gcacctggtg ataggggtga acctggacca cctggtccag ctggttttgc tggtcctcct     2700

ggagctgatg gacaacctgg cgcaaagggt gaaccaggtg atgctggcgc aaagggagat     2760

gctggtccac ctggacctgc tggtccagca ggcccccctg ggccaatcgg taatgttgga     2820

gcaccaggtg ctaagggagc taggggttcc gctggtccac ctggagcaac aggatttcca     2880

ggcgctgctg gtagagttgg cccaccaggc ccatccggaa acgcaggccc tcctggtcct     2940

ccaggtcctg ctggcaagga gggtggcaaa ggaccaaggg gcgaaactgg ccctgctggt     3000

agacctggcg aagttggccc tcctggacca ccaggtccag caggagaaaa aggttcccca     3060

ggagctgatg gcccagctgg tgctccagga actccaggcc ctcaaggtat tgctggacag     3120

agaggcgttg tgggactccc tggtcaaagg ggagagagag gatttccagg cttgccagga     3180

cctagtggag aacctggaaa acaaggccca tcaggcgcta gtggagagcg tggacctcct     3240

ggccctatgg gacctcctgg attggctggc ccacctggcg aatcaggtcg tgaaggcgca     3300

ccaggcgcag aaggatcacc tggaagagat ggatcccctg gtgctaaagg cgatcgtgga     3360

gaaactggtc cagcaggccc accaggcgca ccaggtgcac ctggcgctcc aggacctgtg     3420

ggaccagctg gaaaatccgg agataggggc gagacaggcc cagcaggacc agctggacct     3480

gttggccctg ctggcgctcg tggaccagca ggacctcaag gaccaagggg agataaggga     3540

gaaacaggcg aacaaggcga taggggcatt aagggtcata ggggttttag tggcctccag     3600

ggtcctcctg gcccacctgg atcaccagga gaacagggac catctggtgc ttccggccca     3660

gctggtccaa gaggacctcc aggatcagct ggtgcacctg gaaaagatgg tcttaacggt     3720

ctcccaggac caatcggccc tccaggacct agaggaagaa caggagatgc tggccctgtt     3780

ggccctccag gacctcctgg tccaccaggt ccacctggtc ctccatcagc tggattcgat     3840

ttttcatttc ttccacagcc accacaagag aaagctcacg atggcggcag atattaccgt     3900

gctgatgatg ctaacgttgt tagggataga gatttggaag tggatacaac tttgaaatcc     3960

ctctcccagc aaattgaaaa cattagatct ccagaaggtt cacgtaaaaa cccagctaga     4020

acatgtcgtg atttgaaaat gtgtcactcc gattggaaaa gtggtgaata ctggattgat     4080

ccaaatcagg gctgtaatct cgatgctatc aaagttttct gtaacatgga aacaggcgaa     4140

acatgcgttt atcctactca accttccgtg gctcagaaaa attggtacat ctcaaaaaat     4200

cctaaagata agaggcacgt ttggttcggt gaaagtatga ctgatggatt tcaatttgag     4260

tacggcggtc aaggtagtga tccagctgat gtggctattc aactcacatt tttgcgtctt     4320

atgtccacag aggcatcaca aaacatcact taccactgca aaaacagtgt ggcttatatg     4380

gatcaacaaa caggaaacct taagaaggct cttcttttga agggctcaaa cgagattgag     4440

attagagcag agggcaactc aaggtttact tattcagtta ctgttgatgg ctgcacttca     4500

catactggcg cttggggtaa aacagttatc gagtataaga ctacaaaaac atcaagactc     4560

ccaatcattg atgttgctcc tctcgatgtt ggcgctcctg atcaagagtt cggttttgat     4620

gtgggcccag tttgtttcct ctaatgagct cgcggccgca tc                        4662


<210>  2
<211>  4362
<212>  DNA
<213>  Artificial Sequence - collagen alpha chain 2

<220>
<223>  "Synthetic sequence containing the coding regions of the vacuolar
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Collagen alpha 2(I) chain and 
       flanking regions"

<400>  2
gcgatgcatg taatgtcatg agccacatga tccaatggcc acaggaacgt aagaatgtag       60

atagatttga ttttgtccgt tagatagcaa acaacattat aaaaggtgtg tatcaatacg      120

aactaattca ctcattggat tcatagaagt ccattcctcc taagtatcta aaccatggct      180

cacgctcgtg ttctcctcct cgctctcgct gttttggcaa cagctgctgt ggctgtggct      240

tcaagttcta gttttgctga ttccaaccca attcgtccag ttactgatag agcagcttcc      300

actttggctc aattgcttca agaagaaact gtgaggaagg gccctgctgg cgataggggc      360

cctaggggcg aaaggggtcc accaggacct ccaggcaggg atggcgaaga tggtccaact      420

ggccctcctg gacctcctgg ccctccaggg ccacccggct tgggcggaaa cttcgcagct      480

caatacgatg gcaagggtgt tggtcttggt cctggtccta tgggcttgat gggacctaga      540

ggcccacctg gtgctgctgg tgctcctgga ccacagggtt ttcagggacc agctggcgag      600

ccaggagagc caggccaaac aggaccagct ggtgcaaggg gacctgctgg acctcctgga      660

aaagctggtg aagatggtca cccaggcaaa ccaggacgtc ctggcgaaag aggtgttgtt      720

ggaccacaag gcgctagggg atttccaggt acacctggat tgccaggttt taagggcatt      780

cgtggtcata acggcctcga tggattgaag ggacagcctg gcgcacctgg cgttaagggt      840

gaacctggag caccaggtga aaacggtact cctggccaga ctggtgcaag aggactccca      900

ggtgaaaggg gtagagttgg tgctcctgga cctgctggag ctaggggtag tgatggtagt      960

gttggtcctg tgggccctgc tggtccaatc ggttccgctg gcccacctgg attcccaggc     1020

gctccaggac ctaaaggaga aatcggtgct gtgggtaacg caggtcctac tggtccagca     1080

ggtcctcgtg gagaagtggg attgccagga ctttctggtc cagtgggccc tccaggcaac     1140

cctggagcta acggcttgac aggagctaaa ggcgcagcag gactccctgg agtggctggc     1200

gcaccaggat tgcctggtcc aaggggtatc ccaggccctg ttggcgcagc tggagctact     1260

ggtgcacgtg gacttgttgg cgaaccaggc cctgctggat caaaaggcga gtctggaaat     1320

aagggagaac ctggttctgc tggacctcaa ggtcctcctg gaccttctgg agaagaagga     1380

aaaaggggac caaatggcga ggctggatca gcaggtccac caggaccacc tggacttcgt     1440

ggatcccctg gtagtagagg acttccaggc gctgatggta gagcaggcgt tatgggacca     1500

ccaggaagta gaggagcatc cggtccagca ggagttaggg gtcctaacgg agatgctggt     1560

agaccaggtg aaccaggtct tatgggccca aggggcctcc caggtagtcc aggaaatatc     1620

ggccctgctg gaaaagaagg ccctgttgga cttccaggta ttgatggacg tcctggccct     1680

attggcccag caggtgcaag aggagaacct ggcaatattg gatttccagg accaaagggt     1740

ccaacaggcg atcctggaaa aaatggagat aagggtcatg ctggattggc aggcgcaagg     1800

ggcgctcctg gtccagatgg aaacaacggc gcacagggtc cacctggccc tcagggtgtt     1860

caaggcggaa aaggcgaaca aggcccagct ggaccaccag gctttcaagg cttgccagga     1920

ccaagtggtc cagcaggtga agttggcaag ccaggcgagc gtggacttca tggcgagttt     1980

ggactccctg gaccagcagg accaaggggt gaaagaggcc ctcctggaga gagtggcgct     2040

gctggaccaa caggcccaat cggtagtaga ggtcctagtg gacctccagg cccagatgga     2100

aataagggtg aaccaggagt tgtgggcgct gttggaacag ctggtccttc aggaccatca     2160

ggactcccag gcgagagagg cgctgctggc attcctggag gaaaaggtga aaaaggcgaa     2220

cctggcctcc gtggcgaaat cggaaatcct ggacgtgatg gtgctcgtgg tgcacacggc     2280

gctgtgggcg ctccaggccc tgctggtgct actggtgata gaggagaggc tggcgcagct     2340

ggcccagcag gtcctgctgg cccaaggggt agtcctggtg aaagaggcga agttggacct     2400

gctggcccta acggctttgc tggccctgct ggagcagcag gtcaacctgg cgctaaaggt     2460

gaaaggggcg gaaagggccc aaaaggtgaa aatggcgttg tgggaccaac tggtccagtg     2520

ggcgcagctg gacctgctgg tccaaatgga ccaccaggac cagcaggtag tagaggagat     2580

ggtggacctc caggaatgac aggttttcca ggtgctgctg gtagaacagg acctcctggt     2640

cctagtggta tttctggtcc accaggacca ccaggtcctg ctggaaaaga aggattgagg     2700

ggtccacgtg gtgatcaagg accagtgggc agaactggtg aagttggcgc agtgggacca     2760

cctggttttg ctggagaaaa gggcccttct ggagaggcag gaacagctgg tcctcctggt     2820

acacctggac ctcaaggact tttgggtgca cctggtattc tcggattgcc aggaagtagg     2880

ggcgaacgtg gacttcctgg cgtggcagga gcagttggag aacctggccc tctcggaatc     2940

gcaggcccac caggcgcaag aggaccacca ggagctgttg gatcaccagg cgtgaatggt     3000

gcacctggcg aggctggtcg tgatggaaac ccaggaaatg atggcccacc aggaagagat     3060

ggtcaacctg gacacaaagg cgagaggggc tacccaggaa atattggccc agttggtgct     3120

gctggcgcac caggcccaca cggtccagtt ggaccagcag gaaaacacgg taatcgtggc     3180

gaaacaggcc cttcaggccc agtgggacct gctggtgctg ttggcccaag aggaccatct     3240

ggacctcaag gcattagagg cgataaggga gagcctggcg aaaaaggacc tagaggcttg     3300

cctggtttta aaggacacaa cggtctccaa ggacttccag gtatcgctgg tcatcatgga     3360

gatcagggtg ctcctggatc agtgggtcca gcaggtccta gaggcccagc aggcccttcc     3420

ggtccagcag gaaaggatgg acgtactggc caccctggaa ctgtgggccc tgctggaatt     3480

agaggtcctc aaggtcatca gggccctgct ggccctccag gtccaccagg tcctccaggc     3540

ccaccaggag tttcaggtgg tggttacgat tttggttacg atggtgattt ttaccgtgct     3600

gatcaaccta gaagtgctcc ttctctccgt cctaaagatt atgaagttga tgctactttg     3660

aaatcactta acaaccagat tgagactctt ctcacacctg agggatcaag aaagaatcca     3720

gcacgtacat gccgtgatct cagacttagt cacccagagt ggtcaagtgg ctattattgg     3780

attgatccta atcagggttg tacaatggag gctatcaaag tttactgtga ttttccaact     3840

ggagagacat gtattagggc acaacctgag aacattccag ctaaaaattg gtatcgttcc     3900

tctaaagata agaaacatgt ttggctcgga gagactatta acgctggttc tcagttcgag     3960

tataatgttg agggcgttac ttctaaagag atggcaactc agctcgcttt tatgagattg     4020

ctcgctaact acgcatccca aaacatcact tatcactgca aaaattccat tgcatatatg     4080

gatgaggaga caggaaattt gaagaaagca gttattctcc aaggtagtaa cgatgttgag     4140

cttgtggctg agggaaatag tagattcact tacacagttt tggtggatgg atgctcaaag     4200

aaaactaatg agtggggcaa gacaatcatt gagtacaaga caaataagcc ttctaggctc     4260

ccatttctcg atattgcacc tcttgatatc ggaggagctg atcacgagtt ttttgttgat     4320

atcggacctg tttgttttaa gtaatgagct cgcggccgca tc                        4362


<210>  3
<211>  1489
<212>  PRT
<213>  Artificial Sequence - collagen alpha 1

<220>
<223>  human collagen alpha-1 chain

<400>  3

Met Ala His Ala Arg Val Leu Leu Leu Ala Leu Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Ala Val Ala Val Ala Ser Ser Ser Ser Phe Ala Asp Ser Asn Pro 
            20                  25                  30          


Ile Arg Pro Val Thr Asp Arg Ala Ala Ser Thr Leu Ala Gln Leu Gln 
        35                  40                  45              


Glu Glu Gly Gln Val Glu Gly Gln Asp Glu Asp Ile Pro Pro Ile Thr 
    50                  55                  60                  


Cys Val Gln Asn Gly Leu Arg Tyr His Asp Arg Asp Val Trp Lys Pro 
65                  70                  75                  80  


Glu Pro Cys Arg Ile Cys Val Cys Asp Asn Gly Lys Val Leu Cys Asp 
                85                  90                  95      


Asp Val Ile Cys Asp Glu Thr Lys Asn Cys Pro Gly Ala Glu Val Pro 
            100                 105                 110         


Glu Gly Glu Cys Cys Pro Val Cys Pro Asp Gly Ser Glu Ser Pro Thr 
        115                 120                 125             


Asp Gln Glu Thr Thr Gly Val Glu Gly Pro Lys Gly Asp Thr Gly Pro 
    130                 135                 140                 


Arg Gly Pro Arg Gly Pro Ala Gly Pro Pro Gly Arg Asp Gly Ile Pro 
145                 150                 155                 160 


Gly Gln Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
                165                 170                 175     


Pro Pro Gly Leu Gly Gly Asn Phe Ala Pro Gln Leu Ser Tyr Gly Tyr 
            180                 185                 190         


Asp Glu Lys Ser Thr Gly Gly Ile Ser Val Pro Gly Pro Met Gly Pro 
        195                 200                 205             


Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Pro Gln 
    210                 215                 220                 


Gly Phe Gln Gly Pro Pro Gly Glu Pro Gly Glu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Pro Met Gly Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Asn Gly Asp 
                245                 250                 255     


Asp Gly Glu Ala Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Pro Pro 
            260                 265                 270         


Gly Pro Gln Gly Ala Arg Gly Leu Pro Gly Thr Ala Gly Leu Pro Gly 
        275                 280                 285             


Met Lys Gly His Arg Gly Phe Ser Gly Leu Asp Gly Ala Lys Gly Asp 
    290                 295                 300                 


Ala Gly Pro Ala Gly Pro Lys Gly Glu Pro Gly Ser Pro Gly Glu Asn 
305                 310                 315                 320 


Gly Ala Pro Gly Gln Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly 
                325                 330                 335     


Arg Pro Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Asn Asp Gly Ala 
            340                 345                 350         


Thr Gly Ala Ala Gly Pro Pro Gly Pro Thr Gly Pro Ala Gly Pro Pro 
        355                 360                 365             


Gly Phe Pro Gly Ala Val Gly Ala Lys Gly Glu Ala Gly Pro Gln Gly 
    370                 375                 380                 


Pro Arg Gly Ser Glu Gly Pro Gln Gly Val Arg Gly Glu Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ala Gly Pro Ala Gly Asn Pro Gly Ala Asp 
                405                 410                 415     


Gly Gln Pro Gly Ala Lys Gly Ala Asn Gly Ala Pro Gly Ile Ala Gly 
            420                 425                 430         


Ala Pro Gly Phe Pro Gly Ala Arg Gly Pro Ser Gly Pro Gln Gly Pro 
        435                 440                 445             


Gly Gly Pro Pro Gly Pro Lys Gly Asn Ser Gly Glu Pro Gly Ala Pro 
    450                 455                 460                 


Gly Ser Lys Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Pro Val Gly 
465                 470                 475                 480 


Val Gln Gly Pro Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala 
                485                 490                 495     


Arg Gly Glu Pro Gly Pro Thr Gly Leu Pro Gly Pro Pro Gly Glu Arg 
            500                 505                 510         


Gly Gly Pro Gly Ser Arg Gly Phe Pro Gly Ala Asp Gly Val Ala Gly 
        515                 520                 525             


Pro Lys Gly Pro Ala Gly Glu Arg Gly Ser Pro Gly Pro Ala Gly Pro 
    530                 535                 540                 


Lys Gly Ser Pro Gly Glu Ala Gly Arg Pro Gly Glu Ala Gly Leu Pro 
545                 550                 555                 560 


Gly Ala Lys Gly Leu Thr Gly Ser Pro Gly Ser Pro Gly Pro Asp Gly 
                565                 570                 575     


Lys Thr Gly Pro Pro Gly Pro Ala Gly Gln Asp Gly Arg Pro Gly Pro 
            580                 585                 590         


Pro Gly Pro Pro Gly Ala Arg Gly Gln Ala Gly Val Met Gly Phe Pro 
        595                 600                 605             


Gly Pro Lys Gly Ala Ala Gly Glu Pro Gly Lys Ala Gly Glu Arg Gly 
    610                 615                 620                 


Val Pro Gly Pro Pro Gly Ala Val Gly Pro Ala Gly Lys Asp Gly Glu 
625                 630                 635                 640 


Ala Gly Ala Gln Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg 
                645                 650                 655     


Gly Glu Gln Gly Pro Ala Gly Ser Pro Gly Phe Gln Gly Leu Pro Gly 
            660                 665                 670         


Pro Ala Gly Pro Pro Gly Glu Ala Gly Lys Pro Gly Glu Gln Gly Val 
        675                 680                 685             


Pro Gly Asp Leu Gly Ala Pro Gly Pro Ser Gly Ala Arg Gly Glu Arg 
    690                 695                 700                 


Gly Phe Pro Gly Glu Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
705                 710                 715                 720 


Pro Arg Gly Ala Asn Gly Ala Pro Gly Asn Asp Gly Ala Lys Gly Asp 
                725                 730                 735     


Ala Gly Ala Pro Gly Ala Pro Gly Ser Gln Gly Ala Pro Gly Leu Gln 
            740                 745                 750         


Gly Met Pro Gly Glu Arg Gly Ala Ala Gly Leu Pro Gly Pro Lys Gly 
        755                 760                 765             


Asp Arg Gly Asp Ala Gly Pro Lys Gly Ala Asp Gly Ser Pro Gly Lys 
    770                 775                 780                 


Asp Gly Val Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala 
785                 790                 795                 800 


Gly Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Ser Gly Pro Ala Gly 
                805                 810                 815     


Pro Thr Gly Ala Arg Gly Ala Pro Gly Asp Arg Gly Glu Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro 
        835                 840                 845             


Gly Ala Lys Gly Glu Pro Gly Asp Ala Gly Ala Lys Gly Asp Ala Gly 
    850                 855                 860                 


Pro Pro Gly Pro Ala Gly Pro Ala Gly Pro Pro Gly Pro Ile Gly Asn 
865                 870                 875                 880 


Val Gly Ala Pro Gly Ala Lys Gly Ala Arg Gly Ser Ala Gly Pro Pro 
                885                 890                 895     


Gly Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly 
            900                 905                 910         


Pro Ser Gly Asn Ala Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys 
        915                 920                 925             


Glu Gly Gly Lys Gly Pro Arg Gly Glu Thr Gly Pro Ala Gly Arg Pro 
    930                 935                 940                 


Gly Glu Val Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly 
945                 950                 955                 960 


Ser Pro Gly Ala Asp Gly Pro Ala Gly Ala Pro Gly Thr Pro Gly Pro 
                965                 970                 975     


Gln Gly Ile Ala Gly Gln Arg Gly Val Val Gly Leu Pro Gly Gln Arg 
            980                 985                 990         


Gly Glu Arg Gly Phe Pro Gly Leu  Pro Gly Pro Ser Gly  Glu Pro Gly 
        995                 1000                 1005             


Lys Gln  Gly Pro Ser Gly Ala  Ser Gly Glu Arg Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro Pro Gly  Glu Ser Gly 
    1025                 1030                 1035             


Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser Pro Gly  Arg Asp Gly 
    1040                 1045                 1050             


Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu Thr Gly  Pro Ala Gly 
    1055                 1060                 1065             


Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala Pro Gly  Pro Val Gly 
    1070                 1075                 1080             


Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu Thr Gly  Pro Ala Gly 
    1085                 1090                 1095             


Pro Ala  Gly Pro Val Gly Pro  Ala Gly Ala Arg Gly  Pro Ala Gly 
    1100                 1105                 1110             


Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu Thr Gly  Glu Gln Gly 
    1115                 1120                 1125             


Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe Ser Gly  Leu Gln Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu Gln Gly  Pro Ser Gly 
    1145                 1150                 1155             


Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro Pro Gly  Ser Ala Gly 
    1160                 1165                 1170             


Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu Pro Gly  Pro Ile Gly 
    1175                 1180                 1185             


Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp Ala Gly  Pro Val Gly 
    1190                 1195                 1200             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Ser 
    1205                 1210                 1215             


Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln Pro Pro  Gln Glu Lys 
    1220                 1225                 1230             


Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala Asp Asp  Ala Asn Val 
    1235                 1240                 1245             


Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr Thr Leu  Lys Ser Leu 
    1250                 1255                 1260             


Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro Glu Gly  Ser Arg Lys 
    1265                 1270                 1275             


Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys Met Cys  His Ser Asp 
    1280                 1285                 1290             


Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro Asn Gln  Gly Cys Asn 
    1295                 1300                 1305             


Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met Glu Thr  Gly Glu Thr 
    1310                 1315                 1320             


Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala Gln Lys  Asn Trp Tyr 
    1325                 1330                 1335             


Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His Val Trp  Phe Gly Glu 
    1340                 1345                 1350             


Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr Gly Gly  Gln Gly Ser 
    1355                 1360                 1365             


Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr Phe Leu  Arg Leu Met 
    1370                 1375                 1380             


Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr His Cys  Lys Asn Ser 
    1385                 1390                 1395             


Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn Leu Lys  Lys Ala Leu 
    1400                 1405                 1410             


Leu Leu  Lys Gly Ser Asn Glu  Ile Glu Ile Arg Ala  Glu Gly Asn 
    1415                 1420                 1425             


Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp Gly Cys  Thr Ser His 
    1430                 1435                 1440             


Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu Tyr Lys  Thr Thr Lys 
    1445                 1450                 1455             


Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala Pro Leu  Asp Val Gly 
    1460                 1465                 1470             


Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val Gly Pro  Val Cys Phe 
    1475                 1480                 1485             


Leu 
    


<210>  4
<211>  1389
<212>  PRT
<213>  Artificial Sequence - collagen alpha 2

<220>
<223>  human collagen alpha-2 chain

<400>  4

Met Ala His Ala Arg Val Leu Leu Leu Ala Leu Ala Val Leu Ala Thr 
1               5                   10                  15      


Ala Ala Val Ala Val Ala Ser Ser Ser Ser Phe Ala Asp Ser Asn Pro 
            20                  25                  30          


Ile Arg Pro Val Thr Asp Arg Ala Ala Ser Thr Leu Ala Gln Leu Leu 
        35                  40                  45              


Gln Glu Glu Thr Val Arg Lys Gly Pro Ala Gly Asp Arg Gly Pro Arg 
    50                  55                  60                  


Gly Glu Arg Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Glu Asp Gly 
65                  70                  75                  80  


Pro Thr Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu 
                85                  90                  95      


Gly Gly Asn Phe Ala Ala Gln Tyr Asp Gly Lys Gly Val Gly Leu Gly 
            100                 105                 110         


Pro Gly Pro Met Gly Leu Met Gly Pro Arg Gly Pro Pro Gly Ala Ala 
        115                 120                 125             


Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Ala Gly Glu Pro Gly 
    130                 135                 140                 


Glu Pro Gly Gln Thr Gly Pro Ala Gly Ala Arg Gly Pro Ala Gly Pro 
145                 150                 155                 160 


Pro Gly Lys Ala Gly Glu Asp Gly His Pro Gly Lys Pro Gly Arg Pro 
                165                 170                 175     


Gly Glu Arg Gly Val Val Gly Pro Gln Gly Ala Arg Gly Phe Pro Gly 
            180                 185                 190         


Thr Pro Gly Leu Pro Gly Phe Lys Gly Ile Arg Gly His Asn Gly Leu 
        195                 200                 205             


Asp Gly Leu Lys Gly Gln Pro Gly Ala Pro Gly Val Lys Gly Glu Pro 
    210                 215                 220                 


Gly Ala Pro Gly Glu Asn Gly Thr Pro Gly Gln Thr Gly Ala Arg Gly 
225                 230                 235                 240 


Leu Pro Gly Glu Arg Gly Arg Val Gly Ala Pro Gly Pro Ala Gly Ala 
                245                 250                 255     


Arg Gly Ser Asp Gly Ser Val Gly Pro Val Gly Pro Ala Gly Pro Ile 
            260                 265                 270         


Gly Ser Ala Gly Pro Pro Gly Phe Pro Gly Ala Pro Gly Pro Lys Gly 
        275                 280                 285             


Glu Ile Gly Ala Val Gly Asn Ala Gly Pro Thr Gly Pro Ala Gly Pro 
    290                 295                 300                 


Arg Gly Glu Val Gly Leu Pro Gly Leu Ser Gly Pro Val Gly Pro Pro 
305                 310                 315                 320 


Gly Asn Pro Gly Ala Asn Gly Leu Thr Gly Ala Lys Gly Ala Ala Gly 
                325                 330                 335     


Leu Pro Gly Val Ala Gly Ala Pro Gly Leu Pro Gly Pro Arg Gly Ile 
            340                 345                 350         


Pro Gly Pro Val Gly Ala Ala Gly Ala Thr Gly Ala Arg Gly Leu Val 
        355                 360                 365             


Gly Glu Pro Gly Pro Ala Gly Ser Lys Gly Glu Ser Gly Asn Lys Gly 
    370                 375                 380                 


Glu Pro Gly Ser Ala Gly Pro Gln Gly Pro Pro Gly Pro Ser Gly Glu 
385                 390                 395                 400 


Glu Gly Lys Arg Gly Pro Asn Gly Glu Ala Gly Ser Ala Gly Pro Pro 
                405                 410                 415     


Gly Pro Pro Gly Leu Arg Gly Ser Pro Gly Ser Arg Gly Leu Pro Gly 
            420                 425                 430         


Ala Asp Gly Arg Ala Gly Val Met Gly Pro Pro Gly Ser Arg Gly Ala 
        435                 440                 445             


Ser Gly Pro Ala Gly Val Arg Gly Pro Asn Gly Asp Ala Gly Arg Pro 
    450                 455                 460                 


Gly Glu Pro Gly Leu Met Gly Pro Arg Gly Leu Pro Gly Ser Pro Gly 
465                 470                 475                 480 


Asn Ile Gly Pro Ala Gly Lys Glu Gly Pro Val Gly Leu Pro Gly Ile 
                485                 490                 495     


Asp Gly Arg Pro Gly Pro Ile Gly Pro Ala Gly Ala Arg Gly Glu Pro 
            500                 505                 510         


Gly Asn Ile Gly Phe Pro Gly Pro Lys Gly Pro Thr Gly Asp Pro Gly 
        515                 520                 525             


Lys Asn Gly Asp Lys Gly His Ala Gly Leu Ala Gly Ala Arg Gly Ala 
    530                 535                 540                 


Pro Gly Pro Asp Gly Asn Asn Gly Ala Gln Gly Pro Pro Gly Pro Gln 
545                 550                 555                 560 


Gly Val Gln Gly Gly Lys Gly Glu Gln Gly Pro Ala Gly Pro Pro Gly 
                565                 570                 575     


Phe Gln Gly Leu Pro Gly Pro Ser Gly Pro Ala Gly Glu Val Gly Lys 
            580                 585                 590         


Pro Gly Glu Arg Gly Leu His Gly Glu Phe Gly Leu Pro Gly Pro Ala 
        595                 600                 605             


Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly Glu Ser Gly Ala Ala Gly 
    610                 615                 620                 


Pro Thr Gly Pro Ile Gly Ser Arg Gly Pro Ser Gly Pro Pro Gly Pro 
625                 630                 635                 640 


Asp Gly Asn Lys Gly Glu Pro Gly Val Val Gly Ala Val Gly Thr Ala 
                645                 650                 655     


Gly Pro Ser Gly Pro Ser Gly Leu Pro Gly Glu Arg Gly Ala Ala Gly 
            660                 665                 670         


Ile Pro Gly Gly Lys Gly Glu Lys Gly Glu Pro Gly Leu Arg Gly Glu 
        675                 680                 685             


Ile Gly Asn Pro Gly Arg Asp Gly Ala Arg Gly Ala His Gly Ala Val 
    690                 695                 700                 


Gly Ala Pro Gly Pro Ala Gly Ala Thr Gly Asp Arg Gly Glu Ala Gly 
705                 710                 715                 720 


Ala Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Ser Pro Gly Glu 
                725                 730                 735     


Arg Gly Glu Val Gly Pro Ala Gly Pro Asn Gly Phe Ala Gly Pro Ala 
            740                 745                 750         


Gly Ala Ala Gly Gln Pro Gly Ala Lys Gly Glu Arg Gly Gly Lys Gly 
        755                 760                 765             


Pro Lys Gly Glu Asn Gly Val Val Gly Pro Thr Gly Pro Val Gly Ala 
    770                 775                 780                 


Ala Gly Pro Ala Gly Pro Asn Gly Pro Pro Gly Pro Ala Gly Ser Arg 
785                 790                 795                 800 


Gly Asp Gly Gly Pro Pro Gly Met Thr Gly Phe Pro Gly Ala Ala Gly 
                805                 810                 815     


Arg Thr Gly Pro Pro Gly Pro Ser Gly Ile Ser Gly Pro Pro Gly Pro 
            820                 825                 830         


Pro Gly Pro Ala Gly Lys Glu Gly Leu Arg Gly Pro Arg Gly Asp Gln 
        835                 840                 845             


Gly Pro Val Gly Arg Thr Gly Glu Val Gly Ala Val Gly Pro Pro Gly 
    850                 855                 860                 


Phe Ala Gly Glu Lys Gly Pro Ser Gly Glu Ala Gly Thr Ala Gly Pro 
865                 870                 875                 880 


Pro Gly Thr Pro Gly Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu 
                885                 890                 895     


Gly Leu Pro Gly Ser Arg Gly Glu Arg Gly Leu Pro Gly Val Ala Gly 
            900                 905                 910         


Ala Val Gly Glu Pro Gly Pro Leu Gly Ile Ala Gly Pro Pro Gly Ala 
        915                 920                 925             


Arg Gly Pro Pro Gly Ala Val Gly Ser Pro Gly Val Asn Gly Ala Pro 
    930                 935                 940                 


Gly Glu Ala Gly Arg Asp Gly Asn Pro Gly Asn Asp Gly Pro Pro Gly 
945                 950                 955                 960 


Arg Asp Gly Gln Pro Gly His Lys Gly Glu Arg Gly Tyr Pro Gly Asn 
                965                 970                 975     


Ile Gly Pro Val Gly Ala Ala Gly Ala Pro Gly Pro His Gly Pro Val 
            980                 985                 990         


Gly Pro Ala Gly Lys His Gly Asn  Arg Gly Glu Thr Gly  Pro Ser Gly 
        995                 1000                 1005             


Pro Val  Gly Pro Ala Gly Ala  Val Gly Pro Arg Gly  Pro Ser Gly 
    1010                 1015                 1020             


Pro Gln  Gly Ile Arg Gly Asp  Lys Gly Glu Pro Gly  Glu Lys Gly 
    1025                 1030                 1035             


Pro Arg  Gly Leu Pro Gly Phe  Lys Gly His Asn Gly  Leu Gln Gly 
    1040                 1045                 1050             


Leu Pro  Gly Ile Ala Gly His  His Gly Asp Gln Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ser Val  Gly Pro Ala Gly Pro  Arg Gly Pro Ala Gly  Pro Ser Gly 
    1070                 1075                 1080             


Pro Ala  Gly Lys Asp Gly Arg  Thr Gly His Pro Gly  Thr Val Gly 
    1085                 1090                 1095             


Pro Ala  Gly Ile Arg Gly Pro  Gln Gly His Gln Gly  Pro Ala Gly 
    1100                 1105                 1110             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Val Ser Gly 
    1115                 1120                 1125             


Gly Gly  Tyr Asp Phe Gly Tyr  Asp Gly Asp Phe Tyr  Arg Ala Asp 
    1130                 1135                 1140             


Gln Pro  Arg Ser Ala Pro Ser  Leu Arg Pro Lys Asp  Tyr Glu Val 
    1145                 1150                 1155             


Asp Ala  Thr Leu Lys Ser Leu  Asn Asn Gln Ile Glu  Thr Leu Leu 
    1160                 1165                 1170             


Thr Pro  Glu Gly Ser Arg Lys  Asn Pro Ala Arg Thr  Cys Arg Asp 
    1175                 1180                 1185             


Leu Arg  Leu Ser His Pro Glu  Trp Ser Ser Gly Tyr  Tyr Trp Ile 
    1190                 1195                 1200             


Asp Pro  Asn Gln Gly Cys Thr  Met Glu Ala Ile Lys  Val Tyr Cys 
    1205                 1210                 1215             


Asp Phe  Pro Thr Gly Glu Thr  Cys Ile Arg Ala Gln  Pro Glu Asn 
    1220                 1225                 1230             


Ile Pro  Ala Lys Asn Trp Tyr  Arg Ser Ser Lys Asp  Lys Lys His 
    1235                 1240                 1245             


Val Trp  Leu Gly Glu Thr Ile  Asn Ala Gly Ser Gln  Phe Glu Tyr 
    1250                 1255                 1260             


Asn Val  Glu Gly Val Thr Ser  Lys Glu Met Ala Thr  Gln Leu Ala 
    1265                 1270                 1275             


Phe Met  Arg Leu Leu Ala Asn  Tyr Ala Ser Gln Asn  Ile Thr Tyr 
    1280                 1285                 1290             


His Cys  Lys Asn Ser Ile Ala  Tyr Met Asp Glu Glu  Thr Gly Asn 
    1295                 1300                 1305             


Leu Lys  Lys Ala Val Ile Leu  Gln Gly Ser Asn Asp  Val Glu Leu 
    1310                 1315                 1320             


Val Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Thr Val  Leu Val Asp 
    1325                 1330                 1335             


Gly Cys  Ser Lys Lys Thr Asn  Glu Trp Gly Lys Thr  Ile Ile Glu 
    1340                 1345                 1350             


Tyr Lys  Thr Asn Lys Pro Ser  Arg Leu Pro Phe Leu  Asp Ile Ala 
    1355                 1360                 1365             


Pro Leu  Asp Ile Gly Gly Ala  Asp His Glu Phe Phe  Val Asp Ile 
    1370                 1375                 1380             


Gly Pro  Val Cys Phe Lys 
    1385                 


<210>  5
<211>  1633
<212>  DNA
<213>  Artificial Sequence - P4H

<220>
<223>  "Synthetic sequence containing the coding regions of the vacuolar
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Prolyl 4-hydroxylase beta subunit 
       and flanking regions"

<400>  5
ctcgagtaaa ccatggctca tgctagggtt ttgcttttgg ctcttgctgt tcttgctact       60

gctgctgttg ctgtggcttc ttcttcatct ttcgctgatt ctaacccaat taggccagtg      120

actgatagag ctgcttctac tcttgctcaa ttggtcgaca tggatgctcc agaagaggag      180

gatcacgttc ttgtgcttag gaagtctaac ttcgctgaag ctcttgctgc tcacaagtac      240

cttcttgtgg agttttatgc tccttggtgc ggacattgca aagctcttgc tccagagtat      300

gctaaggctg ctggaaagtt gaaggctgag ggatctgaaa ttaggcttgc taaagtggat      360

gctactgagg agtctgatct tgctcaacag tacggagtta ggggataccc aactattaag      420

ttcttcagga acggagatac tgcttctcca aaggagtata ctgctggaag ggaggctgat      480

gatattgtga actggcttaa gaagagaact ggaccagctg ctactactct tccagatgga      540

gctgctgctg aatctcttgt ggagtcatct gaggtggcag tgattggatt cttcaaggat      600

gtggagtctg attctgctaa gcagttcctt caagctgctg aggctattga tgatattcca      660

ttcggaatta cttctaactc tgatgtgttc tctaagtacc agcttgataa ggatggagtg      720

gtgcttttca agaaattcga tgagggaagg aacaatttcg agggagaggt gacaaaggag      780

aaccttcttg atttcattaa gcacaaccag cttccacttg tgattgagtt cactgagcag      840

actgctccaa agattttcgg aggagagatt aagactcaca ttcttctttt ccttccaaag      900

tctgtgtctg attacgatgg aaagttgtct aacttcaaga ctgctgctga gtctttcaag      960

ggaaagattc ttttcatttt cattgattct gatcacactg ataaccagag gattcttgag     1020

ttcttcggac ttaagaagga agagtgccca gctgttaggc ttattactct tgaggaggag     1080

atgactaagt acaagccaga gtctgaagaa cttactgctg agaggattac tgagttctgc     1140

cacagattcc ttgagggaaa gattaagcca caccttatgt ctcaagagct tccagaggat     1200

tgggataagc agccagttaa ggtgttggtg ggtaaaaact tcgaggatgt ggctttcgat     1260

gagaagaaga acgtgttcgt ggagttctac gcaccttggt gtggtcactg taagcagctt     1320

gctccaattt gggataagtt gggagagact tacaaggatc acgagaacat tgtgattgct     1380

aagatggatt ctactgctaa cgaggtggag gctgttaagg ttcactcttt cccaactttg     1440

aagttcttcc cagcttctgc tgataggact gtgattgatt acaacggaga aaggactctt     1500

gatggattca agaagttcct tgagtctgga ggacaagatg gagctggaga tgatgatgat     1560

cttgaggatt tggaagaagc tgaggagcca gatatggagg aggatgatga tcagaaggct     1620

gtgtgatgag ctc                                                        1633


<210>  6
<211>  1723
<212>  DNA
<213>  Artificial Sequence - P4H

<220>
<223>  "Synthetic sequence containing the coding regions of the vacuolar
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Prolyl 4-hydroxylase alpha-1 subunit
       and flanking regions"

<400>  6
ctcgagtaaa ccatggctca tgctagggtt ttgcttttgg ctcttgctgt tcttgctact       60

gctgctgttg ctgtggcttc ttcttcatct ttcgctgatt ctaacccaat taggccagtg      120

actgatagag ctgcttctac tcttgctcaa ttggtcgaca tgcacccagg attcttcact      180

tctattggac agatgactga tcttattcac actgagaagg atcttgtgac ttctcttaag      240

gattacatta aggctgagga ggataagttg gagcagatta agaagtgggc tgagaagttg      300

gataggctta cttctactgc tacaaaagat ccagagggat tcgttggtca tccagtgaac      360

gctttcaagt tgatgaagag gcttaacact gagtggagtg agcttgagaa ccttgtgctt      420

aaggatatgt ctgatggatt catttctaac cttactattc agaggcagta cttcccaaat      480

gatgaggatc aagtgggagc tgctaaggct cttcttaggc ttcaggatac ttacaacctt      540

gatactgata caatttctaa gggaaacctt ccaggagtta agcacaagtc tttccttact      600

gctgaggatt gcttcgagct tggaaaggtt gcatacactg aggctgatta ctaccacact      660

gagctttgga tggaacaagc tcttaggcaa cttgatgagg gagagatttc tactattgat      720

aaggtgtcag tgcttgatta cctttcttac gctgtgtacc agcagggtga tcttgataag      780

gctcttttgc ttactaagaa gttgcttgag cttgatccag aacatcagag ggctaacgga      840

aaccttaagt acttcgagta cattatggct aaggaaaagg atgtgaacaa gtctgcttct      900

gatgatcagt ctgatcaaaa gactactcca aagaagaagg gagtggctgt tgattatctt      960

cctgagaggc agaagtatga gatgttgtgt aggggagagg gtattaagat gactccaagg     1020

aggcagaaga agttgttctg caggtatcac gatggaaaca ggaacccaaa gttcattctt     1080

gctccagcta agcaagaaga tgagtgggat aagccaagga ttattaggtt ccacgatatt     1140

atttctgatg ctgagattga gattgtgaag gatcttgcta agccaagact taggagggct     1200

actatttcta accctattac tggtgatctt gagactgtgc actacaggat ttctaagtct     1260

gcttggcttt ctggatacga gaacccagtg gtgtctagga ttaacatgag gattcaggat     1320

cttactggac ttgatgtgtc tactgctgag gagcttcaag ttgctaacta cggagttgga     1380

ggacaatatg agccacactt cgatttcgct aggaaggatg agccagatgc ttttaaggag     1440

cttggaactg gaaacaggat tgctacttgg cttttctaca tgtctgatgt ttctgctgga     1500

ggagctactg ttttcccaga agtgggagct tctgtttggc caaagaaggg aactgctgtg     1560

ttctggtaca accttttcgc ttctggagag ggagattact ctactaggca tgctgcttgc     1620

ccagttcttg ttggaaacaa gtgggtgtca aacaagtggc ttcatgagag gggacaagag     1680

tttagaaggc catgcactct ttctgagctt gagtgatgag ctc                       1723


<210>  7
<211>  2888
<212>  DNA
<213>  Artificial Sequence - LH3

<220>
<223>  "Synthetic sequence containing the coding regions of the vacuolar
       signal sequence of barley gene for Thiol protease aleurain 
       precursor fused to the human Lysyl hydroxylase 3 and flanking 
       regions"

<400>  7
gcgaattcgc tagctatcac tgaaaagaca gcaagacaat ggtgtctcga tgcaccagaa       60

ccacatcttt gcagcagatg tgaagcagcc agagtggtcc acaagacgca ctcagaaaag      120

gcatcttcta ccgacacaga aaaagacaac cacagctcat catccaacat gtagactgtc      180

gttatgcgtc ggctgaagat aagactgacc ccaggccagc actaaagaag aaataatgca      240

agtggtccta gctccacttt agctttaata attatgtttc attattattc tctgcttttg      300

ctctctatat aaagagcttg tattttcatt tgaaggcaga ggcgaacaca cacacagaac      360

ctccctgctt acaaaccaga tcttaaacca tggctcacgc tagggttttg cttcttgctc      420

ttgctgttct tgctactgct gctgttgctg tggcttcttc aagttctttc gctgattcta      480

acccaattag gccagtgact gatagagctg cttctactct tgctcaattg agatctatgt      540

ctgatagacc aaggggaagg gatccagtta atccagagaa gttgcttgtg attactgtgg      600

ctactgctga gactgaagga taccttagat tccttaggag tgctgagttc ttcaactaca      660

ctgtgaggac tcttggactt ggagaagaat ggaggggagg agatgttgct agaactgttg      720

gaggaggaca gaaagtgaga tggcttaaga aagagatgga gaagtacgct gatagggagg      780

atatgattat tatgttcgtg gattcttacg atgtgattct tgctggatct ccaactgagc      840

ttttgaagaa attcgttcag tctggatcta ggcttctttt ctctgctgag tctttttgtt      900

ggccagaatg gggacttgct gagcaatatc cagaagtggg aactggaaag agattcctta      960

actctggagg attcattgga ttcgctacta ctattcacca gattgtgagg cagtggaagt     1020

acaaggatga cgatgatgat cagcttttct acactaggct ttaccttgat ccaggactta     1080

gggagaagtt gtctcttaac cttgatcaca agtctaggat tttccagaac cttaacggtg     1140

ctcttgatga ggttgtgctt aagttcgata ggaacagagt gaggattagg aacgtggctt     1200

acgatactct tcctattgtg gtgcatggaa acggaccaac aaaactccag cttaactacc     1260

ttggaaacta cgttccaaac ggatggactc cagaaggagg atgtggattc tgcaatcagg     1320

ataggagaac tcttccagga ggacaaccac caccaagagt tttccttgct gtgttcgttg     1380

aacagccaac tccattcctt ccaagattcc ttcagaggct tcttcttttg gattacccac     1440

cagatagggt gacacttttc cttcacaaca acgaggtttt ccacgagcca cacattgctg     1500

attcttggcc acagcttcag gatcatttct ctgctgtgaa gttggttggt ccagaagaag     1560

ctctttctcc aggagaagct agggatatgg ctatggattt gtgcaggcag gatccagagt     1620

gcgagttcta cttctctctt gatgctgatg ctgtgcttac taaccttcag actcttagga     1680

ttcttattga ggagaacagg aaagtgattg ctccaatgct ttctaggcac ggaaagttgt     1740

ggtctaattt ctggggtgct ctttctcctg atgagtacta cgctagatca gaggactacg     1800

tggagcttgt tcagagaaag agagtgggag tttggaacgt tccttatatt tctcaggctt     1860

acgtgattag gggagatact cttaggatgg agcttccaca gagggatgtt ttctctggat     1920

ctgatactga tccagatatg gctttctgca agtctttcag ggataaggga attttccttc     1980

acctttctaa ccagcatgag ttcggaagat tgcttgctac ttcaagatac gatactgagc     2040

accttcatcc tgatctttgg cagattttcg ataacccagt ggattggaag gagcagtaca     2100

ttcacgagaa ctactctagg gctcttgaag gagaaggaat tgtggagcaa ccatgcccag     2160

atgtttactg gttcccactt ctttctgagc aaatgtgcga tgagcttgtt gctgagatgg     2220

agcattacgg acaatggagt ggaggtagac atgaggattc taggcttgct ggaggatacg     2280

agaacgttcc aactgtggat attcacatga agcaagtggg atacgaggat caatggcttc     2340

agcttcttag gacttatgtg ggaccaatga ctgagtctct tttcccagga taccacacta     2400

aggctagggc tgttatgaac ttcgttgtga ggtatcgtcc agatgagcaa ccatctctta     2460

ggccacacca cgattcttct actttcactc ttaacgtggc tcttaaccac aagggacttg     2520

attatgaggg aggaggatgc cgtttcctta gatacgattg cgtgatttct tcaccaagaa     2580

agggatgggc tcttcttcat ccaggaaggc ttactcatta ccacgaggga cttccaacta     2640

cttggggaac tagatatatt atggtgtctt tcgtggatcc atgactgctt taatgagata     2700

tgcgagacgc ctatgatcgc atgatatttg ctttcaattc tgttgtgcac gttgtaaaaa     2760

acctgagcat gtgtagctca gatccttacc gccggtttcg gttcattcta atgaatatat     2820

cacccgttac tatcgtattt ttatgaataa tattctccgt tcaatttact gattgtccag     2880

aattcgcg                                                              2888


