                               SEQUENCE LISTING

<110> AVECTAS LIMITED
 
<120> ENGINEERING OF DENDRITIC CELLS FOR GENERATION OF VACCINES AGAINST
      SARS-COV-2

<130> 048831-524001WO

<140> PCT/IB2021/000161
<141> 2021-03-23

<150> 62/993,461
<151> 2020-03-23

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 1273
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Coronaviridae seuqence"

<400> 1
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210> 2
<211> 29905
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (694)..(694)
<223> a, c, g or t

<400> 2
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct       60

gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact      120

cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc      180

ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt      240

cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac      300

acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg      360

agactccgtg gaggaggtct tatcagaggc acgtcaacat cttaaagatg gcacttgtgg      420

cttagtagaa gttgaaaaag gcgttttgcc tcaacttgaa cagccctatg tgttcatcaa      480

acgttcggat gctcgaactg cacctcatgg tcatgttatg gttgagctgg tagcagaact      540

cgaaggcatt cagtacggtc gtagtggtga gacacttggt gtccttgtcc ctcatgtggg      600

cgaaatacca gtggcttacc gcaaggttct tcttcgtaag aacggtaata aaggagctgg      660

tggccatagt tacggcgccg atctaaagtc atanttgact taggcgacga gcttggcact      720

gatccttatg aagattttca agaaaactgg aacactaaac atagcagtgg tgttacccgt      780

gaactcatgc gtgagcttaa cggaggggca tacactcgct atgtcgataa caacttctgt      840

ggccctgatg gctaccctct tgagtgcatt aaagaccttc tagcacgtgc tggtaaagct      900

tcatgcactt tgtccgaaca actggacttt attgacacta agaggggtgt atactgctgc      960

cgtgaacatg agcatgaaat tgcttggtac acggaacgtt ctgaaaagag ctatgaattg     1020

cagacacctt ttgaaattaa attggcaaag aaatttgaca ccttcaatgg ggaatgtcca     1080

aattttgtat ttcccttaaa ttccataatc aagactattc aaccaagggt tgaaaagaaa     1140

aagcttgatg gctttatggg tagaattcga tctgtctatc cagttgcgtc accaaatgaa     1200

tgcaaccaaa tgtgcctttc aactctcatg aagtgtgatc attgtggtga aacttcatgg     1260

cagacgggcg attttgttaa agccacttgc gaattttgtg gcactgagaa tttgactaaa     1320

gaaggtgcca ctacttgtgg ttacttaccc caaaatgctg ttgttaaaat ttattgtcca     1380

gcatgtcaca attcagaagt aggacctgag catagtcttg ccgaatacca taatgaatct     1440

ggcttgaaaa ccattcttcg taagggtggt cgcactattg cctttggagg ctgtgtgttc     1500

tcttatgttg gttgccataa caagtgtgcc tattgggttc cacgtgctag cgctaacata     1560

ggttgtaacc atacaggtgt tgttggagaa ggttccgaag gtcttaatga caaccttctt     1620

gaaatactcc aaaaagagaa agtcaacatc aatattgttg gtgactttaa acttaatgaa     1680

gagatcgcca ttattttggc atctttttct gcttccacaa gtgcttttgt ggaaactgtg     1740

aaaggtttgg attataaagc attcaaacaa attgttgaat cctgtggtaa ttttaaagtt     1800

acaaaaggaa aagctaaaaa aggtgcctgg aatattggtg aacagaaatc aatactgagt     1860

cctctttatg catttgcatc agaggctgct cgtgttgtac gatcaatttt ctcccgcact     1920

cttgaaactg ctcaaaattc tgtgcgtgtt ttacagaagg ccgctataac aatactagat     1980

ggaatttcac agtattcact gagactcatt gatgctatga tgttcacatc tgatttggct     2040

actaacaatc tagttgtaat ggcctacatt acaggtggtg ttgttcagtt gacttcgcag     2100

tggctaacta acatctttgg cactgtttat gaaaaactca aacccgtcct tgattggctt     2160

gaagagaagt ttaaggaagg tgtagagttt cttagagacg gttgggaaat tgttaaattt     2220

atctcaacct gtgcttgtga aattgtcggt ggacaaattg tcacctgtgc aaaggaaatt     2280

aaggagagtg ttcagacatt ctttaagctt gtaaataaat ttttggcttt gtgtgctgac     2340

tctatcatta ttggtggagc taaacttaaa gccttgaatt taggtgaaac atttgtcacg     2400

cactcaaagg gattgtacag aaagtgtgtt aaatccagag aagaaactgg cctactcatg     2460

cctctaaaag ccccaaaaga aattatcttc ttagagggag aaacacttcc cacagaagtg     2520

ttaacagagg aagttgtctt gaaaactggt gatttacaac cattagaaca acctactagt     2580

gaagctgttg aagctccatt ggttggtaca ccagtttgta ttaacgggct tatgttgctc     2640

gaaatcaaag acacagaaaa gtactgtgcc cttgcaccta atatgatggt aacaaacaat     2700

accttcacac tcaaaggcgg tgcaccaaca aaggttactt ttggtgatga cactgtgata     2760

gaagtgcaag gttacaagag tgtgaatatc acttttgaac ttgatgaaag gattgataaa     2820

gtacttaatg agaagtgctc tgcctataca gttgaactcg gtacagaagt aaatgagttc     2880

gcctgtgttg tggcagatgc tgtcataaaa actttgcaac cagtatctga attacttaca     2940

ccactgggca ttgatttaga tgagtggagt atggctacat actacttatt tgatgagtct     3000

ggtgagttta aattggcttc acatatgtat tgttctttct accctccaga tgaggatgaa     3060

gaagaaggtg attgtgaaga agaagagttt gagccatcaa ctcaatatga gtatggtact     3120

gaagatgatt accaaggtaa acctttggaa tttggtgcca cttctgctgc tcttcaacct     3180

gaagaagagc aagaagaaga ttggttagat gatgatagtc aacaaactgt tggtcaacaa     3240

gacggcagtg aggacaatca gacaactact attcaaacaa ttgttgaggt tcaacctcaa     3300

ttagagatgg aacttacacc agttgttcag actattgaag tgaatagttt tagtggttat     3360

ttaaaactta ctgacaatgt atacattaaa aatgcagaca ttgtggaaga agctaaaaag     3420

gtaaaaccaa cagtggttgt taatgcagcc aatgtttacc ttaaacatgg aggaggtgtt     3480

gcaggagcct taaataaggc tactaacaat gccatgcaag ttgaatctga tgattacata     3540

gctactaatg gaccacttaa agtgggtggt agttgtgttt taagcggaca caatcttgct     3600

aaacactgtc ttcatgttgt cggcccaaat gttaacaaag gtgaagacat tcaacttctt     3660

aagagtgctt atgaaaattt taatcagcac gaagttctac ttgcaccatt attatcagct     3720

ggtatttttg gtgctgaccc tatacattct ttaagagttt gtgtagatac tgttcgcaca     3780

aatgtctact tagctgtctt tgataaaaat ctctatgaca aacttgtttc aagctttttg     3840

gaaatgaaga gtgaaaagca agttgaacaa aagatcgctg agattcctaa agaggaagtt     3900

aagccattta taactgaaag taaaccttca gttgaacaga gaaaacaaga tgataagaaa     3960

atcaaagctt gtgttgaaga agttacaaca actctggaag aaactaagtt cctcacagaa     4020

aacttgttac tttatattga cattaatggc aatcttcatc cagattctgc cactcttgtt     4080

agtgacattg acatcacttt cttaaagaaa gatgctccat atatagtggg tgatgttgtt     4140

caagagggtg ttttaactgc tgtggttata cctactaaaa aggctggtgg cactactgaa     4200

atgctagcga aagctttgag aaaagtgcca acagacaatt atataaccac ttacccgggt     4260

cagggtttaa atggttacac tgtagaggag gcaaagacag tgcttaaaaa gtgtaaaagt     4320

gccttttaca ttctaccatc tattatctct aatgagaagc aagaaattct tggaactgtt     4380

tcttggaatt tgcgagaaat gcttgcacat gcagaagaaa cacgcaaatt aatgcctgtc     4440

tgtgtggaaa ctaaagccat agtttcaact atacagcgta aatataaggg tattaaaata     4500

caagagggtg tggttgatta tggtgctaga ttttactttt acaccagtaa aacaactgta     4560

gcgtcactta tcaacacact taacgatcta aatgaaactc ttgttacaat gccacttggc     4620

tatgtaacac atggcttaaa tttggaagaa gctgctcggt atatgagatc tctcaaagtg     4680

ccagctacag tttctgtttc ttcacctgat gctgttacag cgtataatgg ttatcttact     4740

tcttcttcta aaacacctga agaacatttt attgaaacca tctcacttgc tggttcctat     4800

aaagattggt cctattctgg acaatctaca caactaggta tagaatttct taagagaggt     4860

gataaaagtg tatattacac tagtaatcct accacattcc acctagatgg tgaagttatc     4920

acctttgaca atcttaagac acttctttct ttgagagaag tgaggactat taaggtgttt     4980

acaacagtag acaacattaa cctccacacg caagttgtgg acatgtcaat gacatatgga     5040

caacagtttg gtccaactta tttggatgga gctgatgtta ctaaaataaa acctcataat     5100

tcacatgaag gtaaaacatt ttatgtttta cctaatgatg acactctacg tgttgaggct     5160

tttgagtact accacacaac tgatcctagt tttctgggta ggtacatgtc agcattaaat     5220

cacactaaaa agtggaaata cccacaagtt aatggtttaa cttctattaa atgggcagat     5280

aacaactgtt atcttgccac tgcattgtta acactccaac aaatagagtt gaagtttaat     5340

ccacctgctc tacaagatgc ttattacaga gcaagggctg gtgaagctgc taacttttgt     5400

gcacttatct tagcctactg taataagaca gtaggtgagt taggtgatgt tagagaaaca     5460

atgagttact tgtttcaaca tgccaattta gattcttgca aaagagtctt gaacgtggtg     5520

tgtaaaactt gtggacaaca gcagacaacc cttaagggtg tagaagctgt tatgtacatg     5580

ggcacacttt cttatgaaca atttaagaaa ggtgttcaga taccttgtac gtgtggtaaa     5640

caagctacaa aatatctagt acaacaggag tcaccttttg ttatgatgtc agcaccacct     5700

gctcagtatg aacttaagca tggtacattt acttgtgcta gtgagtacac tggtaattac     5760

cagtgtggtc actataaaca tataacttct aaagaaactt tgtattgcat agacggtgct     5820

ttacttacaa agtcctcaga atacaaaggt cctattacgg atgttttcta caaagaaaac     5880

agttacacaa caaccataaa accagttact tataaattgg atggtgttgt ttgtacagaa     5940

attgacccta agttggacaa ttattataag aaagacaatt cttatttcac agagcaacca     6000

attgatcttg taccaaacca accatatcca aacgcaagct tcgataattt taagtttgta     6060

tgtgataata tcaaatttgc tgatgattta aaccagttaa ctggttataa gaaacctgct     6120

tcaagagagc ttaaagttac atttttccct gacttaaatg gtgatgtggt ggctattgat     6180

tataaacact acacaccctc ttttaagaaa ggagctaaat tgttacataa acctattgtt     6240

tggcatgtta acaatgcaac taataaagcc acgtataaac caaatacctg gtgtatacgt     6300

tgtctttgga gcacaaaacc agttgaaaca tcaaattcgt ttgatgtact gaagtcagag     6360

gacgcgcagg gaatggataa tcttgcctgc gaagatctaa aaccagtctc tgaagaagta     6420

gtggaaaatc ctaccataca gaaagacgtt cttgagtgta atgtgaaaac taccgaagtt     6480

gtaggagaca ttatacttaa accagcaaat aatagtttaa aaattacaga agaggttggc     6540

cacacagatc taatggctgc ttatgtagac aattctagtc ttactattaa gaaacctaat     6600

gaattatcta gagtattagg tttgaaaacc cttgctactc atggtttagc tgctgttaat     6660

agtgtccctt gggatactat agctaattat gctaagcctt ttcttaacaa agttgttagt     6720

acaactacta acatagttac acggtgttta aaccgtgttt gtactaatta tatgccttat     6780

ttctttactt tattgctaca attgtgtact tttactagaa gtacaaattc tagaattaaa     6840

gcatctatgc cgactactat agcaaagaat actgttaaga gtgtcggtaa attttgtcta     6900

gaggcttcat ttaattattt gaagtcacct aatttttcta aactgataaa tattataatt     6960

tggtttttac tattaagtgt ttgcctaggt tctttaatct actcaaccgc tgctttaggt     7020

gttttaatgt ctaatttagg catgccttct tactgtactg gttacagaga aggctatttg     7080

aactctacta atgtcactat tgcaacctac tgtactggtt ctataccttg tagtgtttgt     7140

cttagtggtt tagattcttt agacacctat ccttctttag aaactataca aattaccatt     7200

tcatctttta aatgggattt aactgctttt ggcttagttg cagagtggtt tttggcatat     7260

attcttttca ctaggttttt ctatgtactt ggattggctg caatcatgca attgtttttc     7320

agctattttg cagtacattt tattagtaat tcttggctta tgtggttaat aattaatctt     7380

gtacaaatgg ccccgatttc agctatggtt agaatgtaca tcttctttgc atcattttat     7440

tatgtatgga aaagttatgt gcatgttgta gacggttgta attcatcaac ttgtatgatg     7500

tgttacaaac gtaatagagc aacaagagtc gaatgtacaa ctattgttaa tggtgttaga     7560

aggtcctttt atgtctatgc taatggaggt aaaggctttt gcaaactaca caattggaat     7620

tgtgttaatt gtgatacatt ctgtgctggt agtacattta ttagtgatga agttgcgaga     7680

gacttgtcac tacagtttaa aagaccaata aatcctactg accagtcttc ttacatcgtt     7740

gatagtgtta cagtgaagaa tggttccatc catctttact ttgataaagc tggtcaaaag     7800

acttatgaaa gacattctct ctctcatttt gttaacttag acaacctgag agctaataac     7860

actaaaggtt cattgcctat taatgttata gtttttgatg gtaaatcaaa atgtgaagaa     7920

tcatctgcaa aatcagcgtc tgtttactac agtcagctta tgtgtcaacc tatactgtta     7980

ctagatcagg cattagtgtc tgatgttggt gatagtgcgg aagttgcagt taaaatgttt     8040

gatgcttacg ttaatacgtt ttcatcaact tttaacgtac caatggaaaa actcaaaaca     8100

ctagttgcaa ctgcagaagc tgaacttgca aagaatgtgt ccttagacaa tgtcttatct     8160

acttttattt cagcagctcg gcaagggttt gttgattcag atgtagaaac taaagatgtt     8220

gttgaatgtc ttaaattgtc acatcaatct gacatagaag ttactggcga tagttgtaat     8280

aactatatgc tcacctataa caaagttgaa aacatgacac cccgtgacct tggtgcttgt     8340

attgactgta gtgcgcgtca tattaatgcg caggtagcaa aaagtcacaa cattgctttg     8400

atatggaacg ttaaagattt catgtcattg tctgaacaac tacgaaaaca aatacgtagt     8460

gctgctaaaa agaataactt accttttaag ttgacatgtg caactactag acaagttgtt     8520

aatgttgtaa caacaaagat agcacttaag ggtggtaaaa ttgttaataa ttggttgaag     8580

cagttaatta aagttacact tgtgttcctt tttgttgctg ctattttcta tttaataaca     8640

cctgttcatg tcatgtctaa acatactgac ttttcaagtg aaatcatagg atacaaggct     8700

attgatggtg gtgtcactcg tgacatagca tctacagata cttgttttgc taacaaacat     8760

gctgattttg acacatggtt tagccagcgt ggtggtagtt atactaatga caaagcttgc     8820

ccattgattg ctgcagtcat aacaagagaa gtgggttttg tcgtgcctgg tttgcctggc     8880

acgatattac gcacaactaa tggtgacttt ttgcatttct tacctagagt ttttagtgca     8940

gttggtaaca tctgttacac accatcaaaa cttatagagt acactgactt tgcaacatca     9000

gcttgtgttt tggctgctga atgtacaatt tttaaagatg cttctggtaa gccagtacca     9060

tattgttatg ataccaatgt actagaaggt tctgttgctt atgaaagttt acgccctgac     9120

acacgttatg tgctcatgga tggctctatt attcaatttc ctaacaccta ccttgaaggt     9180

tctgttagag tggtaacaac ttttgattct gagtactgta ggcacggcac ttgtgaaaga     9240

tcagaagctg gtgtttgtgt atctactagt ggtagatggg tacttaacaa tgattattac     9300

agatctttac caggagtttt ctgtggtgta gatgctgtaa atttacttac taatatgttt     9360

acaccactaa ttcaacctat tggtgctttg gacatatcag catctatagt agctggtggt     9420

attgtagcta tcgtagtaac atgccttgcc tactatttta tgaggtttag aagagctttt     9480

ggtgaataca gtcatgtagt tgcctttaat actttactat tccttatgtc attcactgta     9540

ctctgtttaa caccagttta ctcattctta cctggtgttt attctgttat ttacttgtac     9600

ttgacatttt atcttactaa tgatgtttct tttttagcac atattcagtg gatggttatg     9660

ttcacacctt tagtaccttt ctggataaca attgcttata tcatttgtat ttccacaaag     9720

catttctatt ggttctttag taattaccta aagagacgtg tagtctttaa tggtgtttcc     9780

tttagtactt ttgaagaagc tgcgctgtgc acctttttgt taaataaaga aatgtatcta     9840

aagttgcgta gtgatgtgct attacctctt acgcaatata atagatactt agctctttat     9900

aataagtaca agtattttag tggagcaatg gatacaacta gctacagaga agctgcttgt     9960

tgtcatctcg caaaggctct caatgacttc agtaactcag gttctgatgt tctttaccaa    10020

ccaccacaaa cctctatcac ctcagctgtt ttgcagagtg gttttagaaa aatggcattc    10080

ccatctggta aagttgaggg ttgtatggta caagtaactt gtggtacaac tacacttaac    10140

ggtctttggc ttgatgacgt agtttactgt ccaagacatg tgatctgcac ctctgaagac    10200

atgcttaacc ctaattatga agatttactc attcgtaagt ctaatcataa tttcttggta    10260

caggctggta atgttcaact cagggttatt ggacattcta tgcaaaattg tgtacttaag    10320

cttaaggttg atacagccaa tcctaagaca cctaagtata agtttgttcg cattcaacca    10380

ggacagactt tttcagtgtt agcttgttac aatggttcac catctggtgt ttaccaatgt    10440

gctatgaggc ccaatttcac tattaagggt tcattcctta atggttcatg tggtagtgtt    10500

ggttttaaca tagattatga ctgtgtctct ttttgttaca tgcaccatat ggaattacca    10560

actggagttc atgctggcac agacttagaa ggtaactttt atggaccttt tgttgacagg    10620

caaacagcac aagcagctgg tacggacaca actattacag ttaatgtttt agcttggttg    10680

tacgctgctg ttataaatgg agacaggtgg tttctcaatc gatttaccac aactcttaat    10740

gactttaacc ttgtggctat gaagtacaat tatgaacctc taacacaaga ccatgttgac    10800

atactaggac ctctttctgc tcaaactgga attgccgttt tagatatgtg tgcttcatta    10860

aaagaattac tgcaaaatgg tatgaatgga cgtaccatat tgggtagtgc tttattagaa    10920

gatgaattta caccttttga tgttgttaga caatgctcag gtgttacttt ccaaagtgca    10980

gtgaaaagaa caatcaaggg tacacaccac tggttgttac tcacaatttt gacttcactt    11040

ttagttttag tccagagtac tcaatggtct ttgttctttt ttttgtatga aaatgccttt    11100

ttaccttttg ctatgggtat tattgctatg tctgcttttg caatgatgtt tgtcaaacat    11160

aagcatgcat ttctctgttt gtttttgtta ccttctcttg ccactgtagc ttattttaat    11220

atggtctata tgcctgctag ttgggtgatg cgtattatga catggttgga tatggttgat    11280

actagtttgt ctggttttaa gctaaaagac tgtgttatgt atgcatcagc tgtagtgtta    11340

ctaatcctta tgacagcaag aactgtgtat gatgatggtg ctaggagagt gtggacactt    11400

atgaatgtct tgacactcgt ttataaagtt tattatggta atgctttaga tcaagccatt    11460

tccatgtggg ctcttataat ctctgttact tctaactact caggtgtagt tacaactgtc    11520

atgtttttgg ccagaggtat tgtttttatg tgtgttgagt attgccctat tttcttcata    11580

actggtaata cacttcagtg tataatgcta gtttattgtt tcttaggcta tttttgtact    11640

tgttactttg gcctcttttg tttactcaac cgctacttta gactgactct tggtgtttat    11700

gattacttag tttctacaca ggagtttaga tatatgaatt cacagggact actcccaccc    11760

aagaatagca tagatgcctt caaactcaac attaaattgt tgggtgttgg tggcaaacct    11820

tgtatcaaag tagccactgt acagtctaaa atgtcagatg taaagtgcac atcagtagtc    11880

ttactctcag ttttgcaaca actcagagta gaatcatcat ctaaattgtg ggctcaatgt    11940

gtccagttac acaatgacat tctcttagct aaagatacta ctgaagcctt tgaaaaaatg    12000

gtttcactac tttctgtttt gctttccatg cagggtgctg tagacataaa caagctttgt    12060

gaagaaatgc tggacaacag ggcaacctta caagctatag cctcagagtt tagttccctt    12120

ccatcatatg cagcttttgc tactgctcaa gaagcttatg agcaggctgt tgctaatggt    12180

gattctgaag ttgttcttaa aaagttgaag aagtctttga atgtggctaa atctgaattt    12240

gaccgtgatg cagccatgca acgtaagttg gaaaagatgg ctgatcaagc tatgacccaa    12300

atgtataaac aggctagatc tgaggacaag agggcaaaag ttactagtgc tatgcagaca    12360

atgcttttca ctatgcttag aaagttggat aatgatgcac tcaacaacat tatcaacaat    12420

gcaagagatg gttgtgttcc cttgaacata atacctctta caacagcagc caaactaatg    12480

gttgtcatac cagactataa cacatataaa aatacgtgtg atggtacaac atttacttat    12540

gcatcagcat tgtgggaaat ccaacaggtt gtagatgcag atagtaaaat tgttcaactt    12600

agtgaaatta gtatggacaa ttcacctaat ttagcatggc ctcttattgt aacagcttta    12660

agggccaatt ctgctgtcaa attacagaat aatgagctta gtcctgttgc actacgacag    12720

atgtcttgtg ctgccggtac tacacaaact gcttgcactg atgacaatgc gttagcttac    12780

tacaacacaa caaagggagg taggtttgta cttgcactgt tatccgattt acaggatttg    12840

aaatgggcta gattccctaa gagtgatgga actggtacta tctatacaga actggaacca    12900

ccttgtaggt ttgttacaga cacacctaaa ggtcctaaag tgaagtattt atactttatt    12960

aaaggattaa acaacctaaa tagaggtatg gtacttggta gtttagctgc cacagtacgt    13020

ctacaagctg gtaatgcaac agaagtgcct gccaattcaa ctgtattatc tttctgtgct    13080

tttgctgtag atgctgctaa agcttacaaa gattatctag ctagtggggg acaaccaatc    13140

actaattgtg ttaagatgtt gtgtacacac actggtactg gtcaggcaat aacagttaca    13200

ccggaagcca atatggatca agaatccttt ggtggtgcat cgtgttgtct gtactgccgt    13260

tgccacatag atcatccaaa tcctaaagga ttttgtgact taaaaggtaa gtatgtacaa    13320

atacctacaa cttgtgctaa tgaccctgtg ggttttacac ttaaaaacac agtctgtacc    13380

gtctgcggta tgtggaaagg ttatggctgt agttgtgatc aactccgcga acccatgctt    13440

cagtcagctg atgcacaatc gtttttaaac gggtttgcgg tgtaagtgca gcccgtctta    13500

caccgtgcgg cacaggcact agtactgatg tcgtatacag ggcttttgac atctacaatg    13560

ataaagtagc tggttttgct aaattcctaa aaactaattg ttgtcgcttc caagaaaagg    13620

acgaagatga caatttaatt gattcttact ttgtagttaa gagacacact ttctctaact    13680

accaacatga agaaacaatt tataatttac ttaaggattg tccagctgtt gctaaacatg    13740

acttctttaa gtttagaata gacggtgaca tggtaccaca tatatcacgt caacgtctta    13800

ctaaatacac aatggcagac ctcgtctatg ctttaaggca ttttgatgaa ggtaattgtg    13860

acacattaaa agaaatactt gtcacataca attgttgtga tgatgattat ttcaataaaa    13920

aggactggta tgattttgta gaaaacccag atatattacg cgtatacgcc aacttaggtg    13980

aacgtgtacg ccaagctttg ttaaaaacag tacaattctg tgatgccatg cgaaatgctg    14040

gtattgttgg tgtactgaca ttagataatc aagatctcaa tggtaactgg tatgatttcg    14100

gtgatttcat acaaaccacg ccaggtagtg gagttcctgt tgtagattct tattattcat    14160

tgttaatgcc tatattaacc ttgaccaggg ctttaactgc agagtcacat gttgacactg    14220

acttaacaaa gccttacatt aagtgggatt tgttaaaata tgacttcacg gaagagaggt    14280

taaaactctt tgaccgttat tttaaatatt gggatcagac ataccaccca aattgtgtta    14340

actgtttgga tgacagatgc attctgcatt gtgcaaactt taatgtttta ttctctacag    14400

tgttcccacc tacaagtttt ggaccactag tgagaaaaat atttgttgat ggtgttccat    14460

ttgtagtttc aactggatac cacttcagag agctaggtgt tgtacataat caggatgtaa    14520

acttacatag ctctagactt agttttaagg aattacttgt gtatgctgct gaccctgcta    14580

tgcacgctgc ttctggtaat ctattactag ataaacgcac tacgtgcttt tcagtagctg    14640

cacttactaa caatgttgct tttcaaactg tcaaacccgg taattttaac aaagacttct    14700

atgactttgc tgtgtctaag ggtttcttta aggaaggaag ttctgttgaa ttaaaacact    14760

tcttctttgc tcaggatggt aatgctgcta tcagcgatta tgactactat cgttataatc    14820

taccaacaat gtgtgatatc agacaactac tatttgtagt tgaagttgtt gataagtact    14880

ttgattgtta cgatggtggc tgtattaatg ctaaccaagt catcgtcaac aacctagaca    14940

aatcagctgg ttttccattt aataaatggg gtaaggctag actttattat gattcaatga    15000

gttatgagga tcaagatgca cttttcgcat atacaaaacg taatgtcatc cctactataa    15060

ctcaaatgaa tcttaagtat gccattagtg caaagaatag agctcgcacc gtagctggtg    15120

tctctatctg tagtactatg accaatagac agtttcatca aaaattattg aaatcaatag    15180

ccgccactag aggagctact gtagtaattg gaacaagcaa attctatggt ggttggcaca    15240

acatgttaaa aactgtttat agtgatgtag aaaaccctca ccttatgggt tgggattatc    15300

ctaaatgtga tagagccatg cctaacatgc ttagaattat ggcctcactt gttcttgctc    15360

gcaaacatac aacgtgttgt agcttgtcac accgtttcta tagattagct aatgagtgtg    15420

ctcaagtatt gagtgaaatg gtcatgtgtg gcggttcact atatgttaaa ccaggtggaa    15480

cctcatcagg agatgccaca actgcttatg ctaatagtgt ttttaacatt tgtcaagctg    15540

tcacggccaa tgttaatgca cttttatcta ctgatggtaa caaaattgcc gataagtatg    15600

tccgcaattt acaacacaga ctttatgagt gtctctatag aaatagagat gttgacacag    15660

actttgtgaa tgagttttac gcatatttgc gtaaacattt ctcaatgatg atactctctg    15720

acgatgctgt tgtgtgtttc aatagcactt atgcatctca aggtctagtg gctagcataa    15780

agaactttaa gtcagttctt tattatcaaa acaatgtttt tatgtctgaa gcaaaatgtt    15840

ggactgagac tgaccttact aaaggacctc atgaattttg ctctcaacat acaatgctag    15900

ttaaacaggg tgatgattat gtgtaccttc cttacccaga tccatcaaga atcctagggg    15960

ccggctgttt tgtagatgat atcgtaaaaa cagatggtac acttatgatt gaacggttcg    16020

tgtctttagc tatagatgct tacccactta ctaaacatcc taatcaggag tatgctgatg    16080

tctttcattt gtacttacaa tacataagaa agctacatga tgagttaaca ggacacatgt    16140

tagacatgta ttctgttatg cttactaatg ataacacttc aaggtattgg gaacctgagt    16200

tttatgaggc tatgtacaca ccgcatacag tcttacaggc tgttggggct tgtgttcttt    16260

gcaattcaca gacttcatta agatgtggtg cttgcatacg tagaccattc ttatgttgta    16320

aatgctgtta cgaccatgtc atatcaacat cacataaatt agtcttgtct gttaatccgt    16380

atgtttgcaa tgctccaggt tgtgatgtca cagatgtgac tcaactttac ttaggaggta    16440

tgagctatta ttgtaaatca cataaaccac ccattagttt tccattgtgt gctaatggac    16500

aagtttttgg tttatataaa aatacatgtg ttggtagcga taatgttact gactttaatg    16560

caattgcaac atgtgactgg acaaatgctg gtgattacat tttagctaac acctgtactg    16620

aaagactcaa gctttttgca gcagaaacgc tcaaagctac tgaggagaca tttaaactgt    16680

cttatggtat tgctactgta cgtgaagtgc tgtctgacag agaattacat ctttcatggg    16740

aagttggtaa acctagacca ccacttaacc gaaattatgt ctttactggt tatcgtgtaa    16800

ctaaaaacag taaagtacaa ataggagagt acacctttga aaaaggtgac tatggtgatg    16860

ctgttgttta ccgaggtaca acaacttaca aattaaatgt tggtgattat tttgtgctga    16920

catcacatac agtaatgcca ttaagtgcac ctacactagt gccacaagag cactatgtta    16980

gaattactgg cttataccca acactcaata tctcagatga gttttctagc aatgttgcaa    17040

attatcaaaa ggttggtatg caaaagtatt ctacactcca gggaccacct ggtactggta    17100

agagtcattt tgctattggc ctagctctct actacccttc tgctcgcata gtgtatacag    17160

cttgctctca tgccgctgtt gatgcactat gtgagaaggc attaaaatat ttgcctatag    17220

ataaatgtag tagaattata cctgcacgtg ctcgtgtaga gtgttttgat aaattcaaag    17280

tgaattcaac attagaacag tatgtctttt gtactgtaaa tgcattgcct gagacgacag    17340

cagatatagt tgtctttgat gaaatttcaa tggccacaaa ttatgatttg agtgttgtca    17400

atgccagatt acgtgctaag cactatgtgt acattggcga ccctgctcaa ttacctgcac    17460

cacgcacatt gctaactaag ggcacactag aaccagaata tttcaattca gtgtgtagac    17520

ttatgaaaac tataggtcca gacatgttcc tcggaacttg tcggcgttgt cctgctgaaa    17580

ttgttgacac tgtgagtgct ttggtttatg ataataagct taaagcacat aaagacaaat    17640

cagctcaatg ctttaaaatg ttttataagg gtgttatcac gcatgatgtt tcatctgcaa    17700

ttaacaggcc acaaataggc gtggtaagag aattccttac acgtaaccct gcttggagaa    17760

aagctgtctt tatttcacct tataattcac agaatgctgt agcctcaaag attttgggac    17820

taccaactca aactgttgat tcatcacagg gctcagaata tgactatgtc atattcactc    17880

aaaccactga aacagctcac tcttgtaatg taaacagatt taatgttgct attaccagag    17940

caaaagtagg catactttgc ataatgtctg atagagacct ttatgacaag ttgcaattta    18000

caagtcttga aattccacgt aggaatgtgg caactttaca agctgaaaat gtaacaggac    18060

tctttaaaga ttgtagtaag gtaatcactg ggttacatcc tacacaggca cctacacacc    18120

tcagtgttga cactaaattc aaaactgaag gtttatgtgt tgacatacct ggcataccta    18180

aggacatgac ctatagaaga ctcatctcta tgatgggttt taaaatgaat tatcaagtta    18240

atggttaccc taacatgttt atcacccgcg aagaagctat aagacatgta cgtgcatgga    18300

ttggcttcga tgtcgagggg tgtcatgcta ctagagaagc tgttggtacc aatttacctt    18360

tacagctagg tttttctaca ggtgttaacc tagttgctgt acctacaggt tatgttgata    18420

cacctaataa tacagatttt tccagagtta gtgctaaacc accgcctgga gatcaattta    18480

aacacctcat accacttatg tacaaaggac ttccttggaa tgtagtgcgt ataaagattg    18540

tacaaatgtt aagtgacaca cttaaaaatc tctctgacag agtcgtattt gtcttatggg    18600

cacatggctt tgagttgaca tctatgaagt attttgtgaa aataggacct gagcgcacct    18660

gttgtctatg tgatagacgt gccacatgct tttccactgc ttcagacact tatgcctgtt    18720

ggcatcattc tattggattt gattacgtct ataatccgtt tatgattgat gttcaacaat    18780

ggggttttac aggtaaccta caaagcaacc atgatctgta ttgtcaagtc catggtaatg    18840

cacatgtagc tagttgtgat gcaatcatga ctaggtgtct agctgtccac gagtgctttg    18900

ttaagcgtgt tgactggact attgaatatc ctataattgg tgatgaactg aagattaatg    18960

cggcttgtag aaaggttcaa cacatggttg ttaaagctgc attattagca gacaaattcc    19020

cagttcttca cgacattggt aaccctaaag ctattaagtg tgtacctcaa gctgatgtag    19080

aatggaagtt ctatgatgca cagccttgta gtgacaaagc ttataaaata gaagaattat    19140

tctattctta tgccacacat tctgacaaat tcacagatgg tgtatgccta ttttggaatt    19200

gcaatgtcga tagatatcct gctaattcca ttgtttgtag atttgacact agagtgctat    19260

ctaaccttaa cttgcctggt tgtgatggtg gcagtttgta tgtaaataaa catgcattcc    19320

acacaccagc ttttgataaa agtgcttttg ttaatttaaa acaattacca tttttctatt    19380

actctgacag tccatgtgag tctcatggaa aacaagtagt gtcagatata gattatgtac    19440

cactaaagtc tgctacgtgt ataacacgtt gcaatttagg tggtgctgtc tgtagacatc    19500

atgctaatga gtacagattg tatctcgatg cttataacat gatgatctca gctggcttta    19560

gcttgtgggt ttacaaacaa tttgatactt ataacctctg gaacactttt acaagacttc    19620

agagtttaga aaatgtggct tttaatgttg taaataaggg acactttgat ggacaacagg    19680

gtgaagtacc agtttctatc attaataaca ctgtttacac aaaagttgat ggtgttgatg    19740

tagaattgtt tgaaaataaa acaacattac ctgttaatgt agcatttgag ctttgggcta    19800

agcgcaacat taaaccagta ccagaggtga aaatactcaa taatttgggt gtggacattg    19860

ctgctaatac tgtgatctgg gactacaaaa gagatgctcc agcacatata tctactattg    19920

gtgtttgttc tatgactgac atagccaaga aaccaactga aacgatttgt gcaccactca    19980

ctgtcttttt tgatggtaga gttgatggtc aagtagactt atttagaaat gcccgtaatg    20040

gtgttcttat tacagaaggt agtgttaaag gtttacaacc atctgtaggt cccaaacaag    20100

ctagtcttaa tggagtcaca ttaattggag aagccgtaaa aacacagttc aattattata    20160

agaaagttga tggtgttgtc caacaattac ctgaaactta ctttactcag agtagaaatt    20220

tacaagaatt taaacccagg agtcaaatgg aaattgattt cttagaatta gctatggatg    20280

aattcattga acggtataaa ttagaaggct atgccttcga acatatcgtt tatggagatt    20340

ttagtcatag tcagttaggt ggtttacatc tactgattgg actagctaaa cgttttaagg    20400

aatcaccttt tgaattagaa gattttattc ctatggacag tacagttaaa aactatttca    20460

taacagatgc gcaaacaggt tcatctaagt gtgtgtgttc tgttattgat ttattacttg    20520

atgattttgt tgaaataata aaatcccaag atttatctgt agtttctaag gttgtcaaag    20580

tgactattga ctatacagaa atttcattta tgctttggtg taaagatggc catgtagaaa    20640

cattttaccc aaaattacaa tctagtcaag cgtggcaacc gggtgttgct atgcctaatc    20700

tttacaaaat gcaaagaatg ctattagaaa agtgtgacct tcaaaattat ggtgatagtg    20760

caacattacc taaaggcata atgatgaatg tcgcaaaata tactcaactg tgtcaatatt    20820

taaacacatt aacattagct gtaccctata atatgagagt tatacatttt ggtgctggtt    20880

ctgataaagg agttgcacca ggtacagctg ttttaagaca gtggttgcct acgggtacgc    20940

tgcttgtcga ttcagatctt aatgactttg tctctgatgc agattcaact ttgattggtg    21000

attgtgcaac tgtacataca gctaataaat gggatctcat tattagtgat atgtacgacc    21060

ctaagactaa aaatgttaca aaagaaaatg actctaaaga gggttttttc acttacattt    21120

gtgggtttat acaacaaaag ctagctcttg gaggttccgt ggctataaag ataacagaac    21180

attcttggaa tgctgatctt tataagctca tgggacactt cgcatggtgg acagcctttg    21240

ttactaatgt gaatgcgtca tcatctgaag catttttaat tggatgtaat tatcttggca    21300

aaccacgcga acaaatagat ggttatgtca tgcatgcaaa ttacatattt tggaggaata    21360

caaatccaat tcagttgtct tcctattctt tatttgacat gagtaaattt ccccttaaat    21420

taaggggtac tgctgttatg tctttaaaag aaggtcaaat caatgatatg attttatctc    21480

ttcttagtaa aggtagactt ataattagag aaaacaacag agttgttatt tctagtgatg    21540

ttcttgttaa caactaaacg aacaatgttt gtttttcttg ttttattgcc actagtctct    21600

agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc    21660

acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag    21720

gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg    21780

accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt    21840

gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg    21900

aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa    21960

tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg    22020

atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct    22080

cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt    22140

gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta    22200

gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt    22260

attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt    22320

gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct    22380

aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca    22440

cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc    22500

tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt    22560

acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct    22620

tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca    22680

tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt    22740

actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca    22800

gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc    22860

gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg    22920

tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc    22980

tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta    23040

caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta    23100

ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat    23160

ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt    23220

actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact    23280

actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt    23340

ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat    23400

caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact    23460

tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg    23520

gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct    23580

agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc    23640

attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt    23700

gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc    23760

aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt    23820

ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt    23880

gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca    23940

ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca    24000

agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc    24060

ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca    24120

caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa    24180

tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct    24240

gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca    24300

cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc    24360

aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc    24420

aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca    24480

atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa    24540

attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta    24600

attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt    24660

gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc    24720

cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa    24780

aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa    24840

ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca    24900

caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt    24960

gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta    25020

gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt    25080

aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat    25140

ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg    25200

ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt    25260

atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc    25320

tgctgcaaat ttgatgaaga cgactctgag ccagtgctca aaggagtcaa attacattac    25380

acataaacga acttatggat ttgtttatga gaatcttcac aattggaact gtaactttga    25440

agcaaggtga aatcaaggat gctactcctt cagattttgt tcgcgctact gcaacgatac    25500

cgatacaagc ctcactccct ttcggatggc ttattgttgg cgttgcactt cttgctgttt    25560

ttcagagcgc ttccaaaatc ataaccctca aaaagagatg gcaactagca ctctccaagg    25620

gtgttcactt tgtttgcaac ttgctgttgt tgtttgtaac agtttactca caccttttgc    25680

tcgttgctgc tggccttgaa gccccttttc tctatcttta tgctttagtc tacttcttgc    25740

agagtataaa ctttgtaaga ataataatga ggctttggct ttgctggaaa tgccgttcca    25800

aaaacccatt actttatgat gccaactatt ttctttgctg gcatactaat tgttacgact    25860

attgtatacc ttacaatagt gtaacttctt caattgtcat tacttcaggt gatggcacaa    25920

caagtcctat ttctgaacat gactaccaga ttggtggtta tactgaaaaa tgggaatctg    25980

gagtaaaaga ctgtgttgta ttacacagtt acttcacttc agactattac cagctgtact    26040

caactcaatt gagtacagac actggtgttg aacatgttac cttcttcatc tacaataaaa    26100

ttgttgatga gcctgaagaa catgtccaaa ttcacacaat cgacggttca tccggagttg    26160

ttaatccagt aatggaacca atttatgatg aaccgacgac gactactagc gtgcctttgt    26220

aagcacaagc tgatgagtac gaacttatgt actcattcgt ttcggaagag acaggtacgt    26280

taatagttaa tagcgtactt ctttttcttg ctttcgtggt attcttgcta gttacactag    26340

ccatccttac tgcgcttcga ttgtgtgcgt actgctgcaa tattgttaac gtgagtcttg    26400

taaaaccttc tttttacgtt tactctcgtg ttaaaaatct gaattcttct agagttcctg    26460

atcttctggt ctaaacgaac taaatattat attagttttt ctgtttggaa ctttaatttt    26520

agccatggca gattccaacg gtactattac cgttgaagag cttaaaaagc tccttgaaca    26580

atggaaccta gtaataggtt tcctattcct tacatggatt tgtcttctac aatttgccta    26640

tgccaacagg aataggtttt tgtatataat taagttaatt ttcctctggc tgttatggcc    26700

agtaacttta gcttgttttg tgcttgctgc tgtttacaga ataaattgga tcaccggtgg    26760

aattgctatc gcaatggctt gtcttgtagg cttgatgtgg ctcagctact tcattgcttc    26820

tttcagactg tttgcgcgta cgcgttccat gtggtcattc aatccagaaa ctaacattct    26880

tctcaacgtg ccactccatg gcactattct gaccagaccg cttctagaaa gtgaactcgt    26940

aatcggagct gtgatccttc gtggacatct tcgtattgct ggacaccatc taggacgctg    27000

tgacatcaag gacctgccta aagaaatcac tgttgctaca tcacgaacgc tttcttatta    27060

caaattggga gcttcgcagc gtgtagcagg tgactcaggt tttgctgcat acagtcgcta    27120

caggattggc aactataaat taaacacaga ccattccagt agcagtgaca atattgcttt    27180

gcttgtacag taagtgacaa cagatgtttc atctcgttga ctttcaggtt actatagcag    27240

agatattact aattattatg aggactttta aagtttccat ttggaatctt gattacatca    27300

taaacctcat aattaaaaat ttatctaagt cactaactga gaataaatat tctcaattag    27360

atgaagagca accaatggag attgattaaa cgaacatgaa aattattctt ttcttggcac    27420

tgataacact cgctacttgt gagctttatc actaccaaga gtgtgttaga ggtacaacag    27480

tacttttaaa agaaccttgc tcttctggaa catacgaggg caattcacca tttcatcctc    27540

tagctgataa caaatttgca ctgacttgct ttagcactca atttgctttt gcttgtcctg    27600

acggcgtaaa acacgtctat cagttacgtg ccagatcagt ttcacctaaa ctgttcatca    27660

gacaagagga agttcaagaa ctttactctc caatttttct tattgttgcg gcaatagtgt    27720

ttataacact ttgcttcaca ctcaaaagaa agacagaatg attgaacttt cattaattga    27780

cttctatttg tgctttttag cctttctgct attccttgtt ttaattatgc ttattatctt    27840

ttggttctca cttgaactgc aagatcataa tgaaacttgt cacgcctaaa cgaacatgaa    27900

atttcttgtt ttcttaggaa tcatcacaac tgtagctgca tttcaccaag aatgtagttt    27960

acagtcatgt actcaacatc aaccatatgt agttgatgac ccgtgtccta ttcacttcta    28020

ttctaaatgg tatattagag taggagctag aaaatcagca cctttaattg aattgtgcgt    28080

ggatgaggct ggttctaaat cacccattca gtacatcgat atcggtaatt atacagtttc    28140

ctgtttacct tttacaatta attgccagga acctaaattg ggtagtcttg tagtgcgttg    28200

ttcgttctat gaagactttt tagagtatca tgacgttcgt gttgttttag atttcatcta    28260

aacgaacaaa ctaaaatgtc tgataatgga ccccaaaatc agcgaaatgc accccgcatt    28320

acgtttggtg gaccctcaga ttcaactggc agtaaccaga atggagaacg cagtggggcg    28380

cgatcaaaac aacgtcggcc ccaaggttta cccaataata ctgcgtcttg gttcaccgct    28440

ctcactcaac atggcaagga agaccttaaa ttccctcgag gacaaggcgt tccaattaac    28500

accaatagca gtccagatga ccaaattggc tactaccgaa gagctaccag acgaattcgt    28560

ggtggtgacg gtaaaatgaa agatctcagt ccaagatggt atttctacta cctaggaact    28620

gggccagaag ctggacttcc ctatggtgct aacaaagacg gcatcatatg ggttgcaact    28680

gagggagcct tgaatacacc aaaagatcac attggcaccc gcaatcctgc taacaatgct    28740

gcaatcgtgc tacaacttcc tcaaggaaca acattgccaa aaggcttcta cgcagaaggg    28800

agcagaggcg gcagtcaagc ctcttctcgt tcctcatcac gtagtcgcaa cagttcaaga    28860

aattcaactc caggcagcag taggggaact tctcctgcta gaatggctgg caatggcggt    28920

gatgctgctc ttgctttgct gctgcttgac agattgaacc agcttgagag caaaatgtct    28980

ggtaaaggcc aacaacaaca aggccaaact gtcactaaga aatctgctgc tgaggcttct    29040

aagaagcctc ggcaaaaacg tactgccact aaagcataca atgtaacaca agctttcggc    29100

agacgtggtc cagaacaaac ccaaggaaat tttggggacc aggaactaat cagacaagga    29160

actgattaca aacattggcc gcaaattgca caatttgccc ccagcgcttc agcgttcttc    29220

ggaatgtcgc gcattggcat ggaagtcaca ccttcgggaa cgtggttgac ctacacaggt    29280

gccatcaaat tggatgacaa agatccaaat ttcaaagatc aagtcatttt gctgaataag    29340

catattgacg catacaaaac attcccacca acagagccta aaaaggacaa aaagaagaag    29400

gctgatgaaa ctcaagcctt accgcagaga cagaagaaac agcaaactgt gactcttctt    29460

cctgctgcag atttggatga tttctccaaa caattgcaac aatccatgag cagtgctgac    29520

tcaactcagg cctaaactca tgcagaccac acaaggcaga tgggctatat aaacgttttc    29580

gcttttccgt ttacgatata tagtctactc ttgtgcagaa tgaattctcg taactacata    29640

gcacaagtag atgtagttaa ctttaatctc acatagcaat ctttaatcag tgtgtaacat    29700

tagggaggac ttgaaagagc caccacattt tcaccgaggc cacgcggagt acgatcgagt    29760

gtacagtgaa caatgctagg gagagctgcc tatatggaag agccctaatg tgtaaaatta    29820

attttagtag tgctatcccc atgtgatttt aatagcttct taggagaatg acaaaaaaaa    29880

aaaaaaaaaa aaaaaaaaaa aaaaa                                          29905


<210> 3
<211> 542
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<223> S1 (Subunit 1 of Spike protein)

<400> 3
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    530                 535                 540         


<210> 4
<211> 215
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Leu Leu Thr Met Ile Ala Arg Val Ala Asp Gly Leu Pro Leu 
1               5                   10                  15      


Ala Ala Ser Met Gln Glu Asp Glu Gln Ser Gly Arg Asp Leu Gln Gln 
            20                  25                  30          


Tyr Gln Ser Gln Ala Lys Gln Leu Phe Arg Lys Leu Asn Glu Gln Ser 
        35                  40                  45              


Pro Thr Arg Cys Thr Leu Glu Ala Gly Ala Met Thr Phe His Tyr Ile 
    50                  55                  60                  


Ile Glu Gln Gly Val Cys Tyr Leu Val Leu Cys Glu Ala Ala Phe Pro 
65                  70                  75                  80  


Lys Lys Leu Ala Phe Ala Tyr Leu Glu Asp Leu His Ser Glu Phe Asp 
                85                  90                  95      


Glu Gln His Gly Lys Lys Val Pro Thr Val Ser Arg Pro Tyr Ser Phe 
            100                 105                 110         


Ile Glu Phe Asp Thr Phe Ile Gln Lys Thr Lys Lys Leu Tyr Ile Asp 
        115                 120                 125             


Ser Arg Ala Arg Arg Asn Leu Gly Ser Ile Asn Thr Glu Leu Gln Asp 
    130                 135                 140                 


Val Gln Arg Ile Met Val Ala Asn Ile Glu Glu Val Leu Gln Arg Gly 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Leu Asp Ser Lys Ala Asn Asn Leu Ser Ser Leu 
                165                 170                 175     


Ser Lys Lys Tyr Arg Gln Asp Ala Lys Tyr Leu Asn Met Arg Ser Thr 
            180                 185                 190         


Tyr Ala Lys Leu Ala Ala Val Ala Val Phe Phe Ile Met Leu Ile Val 
        195                 200                 205             


Tyr Val Arg Phe Trp Trp Leu 
    210                 215 


<210> 5
<211> 1273
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<223> D614G spike protein variant

<400> 5
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210> 6
<211> 215
<212> PRT
<213> Homo sapiens

<400> 6
Met Val Leu Leu Thr Met Ile Ala Arg Val Ala Asp Gly Leu Pro Leu 
1               5                   10                  15      


Ala Ala Ser Met Gln Glu Asp Glu Gln Ser Gly Arg Asp Leu Gln Gln 
            20                  25                  30          


Tyr Gln Ser Gln Ala Lys Gln Leu Phe Arg Lys Leu Asn Glu Gln Ser 
        35                  40                  45              


Pro Thr Arg Cys Thr Leu Glu Ala Gly Ala Met Thr Phe His Tyr Ile 
    50                  55                  60                  


Ile Glu Gln Gly Val Cys Tyr Leu Val Leu Cys Glu Ala Ala Phe Pro 
65                  70                  75                  80  


Lys Lys Leu Ala Phe Ala Tyr Leu Glu Asp Leu His Ser Glu Phe Asp 
                85                  90                  95      


Glu Gln His Gly Lys Lys Val Pro Thr Val Ser Arg Pro Tyr Ser Phe 
            100                 105                 110         


Ile Glu Phe Asp Thr Phe Ile Gln Lys Thr Lys Lys Leu Tyr Ile Asp 
        115                 120                 125             


Ser Arg Ala Arg Arg Asn Leu Gly Ser Ile Asn Thr Glu Leu Gln Asp 
    130                 135                 140                 


Val Gln Arg Ile Met Val Ala Asn Ile Glu Glu Val Leu Gln Arg Gly 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Leu Asp Ser Lys Ala Asn Asn Leu Ser Ser Leu 
                165                 170                 175     


Ser Lys Lys Tyr Arg Gln Asp Ala Lys Tyr Leu Asn Met Arg Ser Thr 
            180                 185                 190         


Tyr Ala Lys Leu Ala Ala Val Ala Val Phe Phe Ile Met Leu Ile Val 
        195                 200                 205             


Tyr Val Arg Phe Trp Trp Leu 
    210                 215 


<210> 7
<211> 648
<212> DNA
<213> Homo sapiens

<400> 7
atggtgttgc taacaatgat cgcccgagtg gcggacgggc tcccgctggc cgcctcgatg       60

caggaggacg aacagtctgg ccgggacctt caacaatatc agagtcaggc taagcaactc      120

tttcgaaagt tgaatgaaca gtcccctacc agatgtacct tggaagcagg agccatgact      180

tttcactaca ttattgagca gggggtgtgt tatttggttt tatgtgaagc tgccttccct      240

aagaagttgg cttttgccta cctagaagat ttgcactcag aatttgatga acagcatgga      300

aagaaggtgc ccactgtgtc ccgaccctat tcctttattg aatttgatac tttcattcag      360

aaaaccaaga agctctacat tgacagtcgt gctcgaagaa atctaggctc catcaacact      420

gaattgcaag atgtgcagag gatcatggtg gccaatattg aagaagtgtt acaacgagga      480

gaagcactct cagcattgga ttcaaaggct aacaatttgt ccagtctgtc caagaaatac      540

cgccaggatg cgaagtactt gaacatgcgt tccacttatg ccaaacttgc agcagtagct      600

gtatttttca tcatgttaat agtgtatgtc cgattctggt ggctgtga                   648


<210> 8
<211> 253
<212> PRT
<213> Homo sapiens

<400> 8
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210> 9
<211> 762
<212> DNA
<213> Homo sapiens

<400> 9
atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg       60

catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc      120

ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc      180

gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg      240

gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct      300

gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta      360

ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact      420

aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt      480

atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg      540

atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg      600

atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg      660

gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca      720

gtgactattg atagagtgat gagctatctg aatgcttcct aa                         762


<210> 10
<211> 125
<212> PRT
<213> Homo sapiens

<400> 10
Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210> 11
<211> 378
<212> DNA
<213> Homo sapiens

<400> 11
atgaagaaaa gtggtgttct tttcctcttg ggcatcatct tgctggttct gattggagtg       60

caaggaaccc cagtagtgag aaagggtcgc tgttcctgca tcagcaccaa ccaagggact      120

atccacctac aatccttgaa agaccttaaa caatttgccc caagcccttc ctgcgagaaa      180

attgaaatca ttgctacact gaagaatgga gttcaaacat gtctaaaccc agattcagca      240

gatgtgaagg aactgattaa aaagtgggag aaacaggtca gccaaaagaa aaagcaaaag      300

aatgggaaaa aacatcaaaa aaagaaagtt ctgaaagttc gaaaatctca acgttctcgt      360

caaaagaaga ctacataa                                                    378


<210> 12
<211> 261
<212> PRT
<213> Homo sapiens

<400> 12
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Val Leu Leu Lys Leu 
            260     


<210> 13
<211> 841
<212> DNA
<213> Homo sapiens

<400> 13
tttaacacag catgatcgaa acatacaacc aaacttctcc ccgatctgcg gccactggac       60

tgcccatcag catgaaaatt tttatgtatt tacttactgt ttttcttatc acccagatga      120

ttgggtcagc actttttgct gtgtatcttc atagaaggtt ggacaagata gaagatgaaa      180

ggaatcttca tgaagatttt gtattcatga aaacgataca gagatgcaac acaggagaaa      240

gatccttatc cttactgaac tgtgaggaga ttaaaagcca gtttgaaggc tttgtgaagg      300

atataatgtt aaacaaagag gagacgaaga aagaaaacag ctttgaaatg caaaaaggtg      360

atcagaatcc tcaaattgcg gcacatgtca taagtgaggc cagcagtaaa acaacatctg      420

tgttacagtg ggctgaaaaa ggatactaca ccatgagcaa caacttggta accctggaaa      480

atgggaaaca gctgaccgtt aaaagacaag gactctatta tatctatgcc caagtcacct      540

tctgttccaa tcgggaagct tcgagtcaag ctccatttat agccagcctc tgcctaaagt      600

cccccggtag attcgagaga atcttactca gagctgcaaa tacccacagt tccgccaaac      660

cttgcgggca acaatccatt cacttgggag gagtatttga attgcaacca ggtgcttcgg      720

tgtttgtcaa tgtgactgat ccaagccaag tgagccatgg cactggcttc acgtcctttg      780

tcttactcaa actctgaaca gtgtcacctt gcaggctgtg gtggagctga cgctgggagt      840

c                                                                      841


<210> 14
<211> 559
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Ala Thr Ser Val Asp Thr Gln Arg Thr Lys Gly Gln Asp Asn 
1               5                   10                  15      


Lys Val Gln Asn Gly Ser Leu His Gln Lys Asp Thr Val His Asp Asn 
            20                  25                  30          


Asp Phe Glu Pro Tyr Leu Thr Gly Gln Ser Asn Gln Ser Asn Ser Tyr 
        35                  40                  45              


Pro Ser Met Ser Asp Pro Tyr Leu Ser Ser Tyr Tyr Pro Pro Ser Ile 
    50                  55                  60                  


Gly Phe Pro Tyr Ser Leu Asn Glu Ala Pro Trp Ser Thr Ala Gly Asp 
65                  70                  75                  80  


Pro Pro Ile Pro Tyr Leu Thr Thr Tyr Gly Gln Leu Ser Asn Gly Asp 
                85                  90                  95      


His His Phe Met His Asp Ala Val Phe Gly Gln Pro Gly Gly Leu Gly 
            100                 105                 110         


Asn Asn Ile Tyr Gln His Arg Phe Asn Phe Phe Pro Glu Asn Pro Ala 
        115                 120                 125             


Phe Ser Ala Trp Gly Thr Ser Gly Ser Gln Gly Gln Gln Thr Gln Ser 
    130                 135                 140                 


Ser Ala Tyr Gly Ser Ser Tyr Thr Tyr Pro Pro Ser Ser Leu Gly Gly 
145                 150                 155                 160 


Thr Val Val Asp Gly Gln Pro Gly Phe His Ser Asp Thr Leu Ser Lys 
                165                 170                 175     


Ala Pro Gly Met Asn Ser Leu Glu Gln Gly Met Val Gly Leu Lys Ile 
            180                 185                 190         


Gly Asp Val Ser Ser Ser Ala Val Lys Thr Val Gly Ser Val Val Ser 
        195                 200                 205             


Ser Val Ala Leu Thr Gly Val Leu Ser Gly Asn Gly Gly Thr Asn Val 
    210                 215                 220                 


Asn Met Pro Val Ser Lys Pro Thr Ser Trp Ala Ala Ile Ala Ser Lys 
225                 230                 235                 240 


Pro Ala Lys Pro Gln Pro Lys Met Lys Thr Lys Ser Gly Pro Val Met 
                245                 250                 255     


Gly Gly Gly Leu Pro Pro Pro Pro Ile Lys His Asn Met Asp Ile Gly 
            260                 265                 270         


Thr Trp Asp Asn Lys Gly Pro Val Pro Lys Ala Pro Val Pro Gln Gln 
        275                 280                 285             


Ala Pro Ser Pro Gln Ala Ala Pro Gln Pro Gln Gln Val Ala Gln Pro 
    290                 295                 300                 


Leu Pro Ala Gln Pro Pro Ala Leu Ala Gln Pro Gln Tyr Gln Ser Pro 
305                 310                 315                 320 


Gln Gln Pro Pro Gln Thr Arg Trp Val Ala Pro Arg Asn Arg Asn Ala 
                325                 330                 335     


Ala Phe Gly Gln Ser Gly Gly Ala Gly Ser Asp Ser Asn Ser Pro Gly 
            340                 345                 350         


Asn Val Gln Pro Asn Ser Ala Pro Ser Val Glu Ser His Pro Val Leu 
        355                 360                 365             


Glu Lys Leu Lys Ala Ala His Ser Tyr Asn Pro Lys Glu Phe Glu Trp 
    370                 375                 380                 


Asn Leu Lys Ser Gly Arg Val Phe Ile Ile Lys Ser Tyr Ser Glu Asp 
385                 390                 395                 400 


Asp Ile His Arg Ser Ile Lys Tyr Ser Ile Trp Cys Ser Thr Glu His 
                405                 410                 415     


Gly Asn Lys Arg Leu Asp Ser Ala Phe Arg Cys Met Ser Ser Lys Gly 
            420                 425                 430         


Pro Val Tyr Leu Leu Phe Ser Val Asn Gly Ser Gly His Phe Cys Gly 
        435                 440                 445             


Val Ala Glu Met Lys Ser Pro Val Asp Tyr Gly Thr Ser Ala Gly Val 
    450                 455                 460                 


Trp Ser Gln Asp Lys Trp Lys Gly Lys Phe Asp Val Gln Trp Ile Phe 
465                 470                 475                 480 


Val Lys Asp Val Pro Asn Asn Gln Leu Arg His Ile Arg Leu Glu Asn 
                485                 490                 495     


Asn Asp Asn Lys Pro Val Thr Asn Ser Arg Asp Thr Gln Glu Val Pro 
            500                 505                 510         


Leu Glu Lys Ala Lys Gln Val Leu Lys Ile Ile Ser Ser Tyr Lys His 
        515                 520                 525             


Thr Thr Ser Ile Phe Asp Asp Phe Ala His Tyr Glu Lys Arg Gln Glu 
    530                 535                 540                 


Glu Glu Glu Val Val Arg Lys Glu Arg Gln Ser Arg Asn Lys Gln 
545                 550                 555                 


<210> 15
<211> 1680
<212> DNA
<213> Homo sapiens

<400> 15
atgtcggcca ccagcgtgga cacccagaga acaaaaggac aagataataa agtacaaaat       60

ggttcgttac atcagaagga tacagttcat gacaatgact ttgagcccta ccttactgga      120

cagtcaaatc agagtaacag ttacccctca atgagcgacc cctacctgtc cagctattac      180

ccgccgtcca ttggatttcc ttactccctc aatgaggctc cgtggtctac tgcaggggac      240

cctccgattc catacctcac cacctacgga cagctcagta acggagacca tcattttatg      300

cacgatgctg tttttgggca gcctgggggc ctggggaaca acatctatca gcacaggttc      360

aattttttcc ctgaaaaccc tgcgttctca gcatggggga caagtgggtc tcaaggtcag      420

cagacccaga gctccgcgta tgggagcagc tacacctacc ccccgagctc cctgggtggc      480

acggtggttg atgggcagcc aggctttcac agcgacaccc tcagcaaggc ccccgggatg      540

aacagcctgg agcagggcat ggttggcctg aagattgggg acgtcagctc ctccgccgtc      600

aagacggtgg gctctgtcgt cagcagcgtg gcactgactg gtgtcctttc tggcaacggt      660

gggacaaatg tgaacatgcc agtttcaaag ccgacctcgt gggctgccat tgccagcaag      720

cctgcaaaac cacagcctaa aatgaaaaca aagagcgggc ctgtcatggg gggtgggctg      780

ccccctccac ccataaagca taacatggac attggcacct gggataacaa ggggcctgtg      840

ccgaaggccc cagtccccca gcaggcaccc tctccacagg ctgccccaca gccccagcag      900

gtggctcagc ctctcccagc acagccccca gctttggctc aaccgcagta tcagagccct      960

cagcagccac cccagacccg ctgggttgcc ccacgcaaca gaaacgcggc gtttgggcag     1020

agcggagggg ctggcagcga tagcaactct cctggaaacg tccagcctaa ttctgccccc     1080

agcgtcgaat cccaccccgt ccttgaaaaa ctgaaggctg ctcacagcta caacccgaaa     1140

gagtttgagt ggaatctgaa aagcgggcgt gtgttcatca tcaagagcta ctctgaggac     1200

gacatccacc gctccattaa gtactccatc tggtgtagca cagagcacgg caacaagcgc     1260

ctggacagcg ccttccgctg catgagcagc aaggggcccg tctacctgct cttcagcgtc     1320

aatgggagtg ggcatttttg tggggtggcc gagatgaagt cccccgtgga ctacggcacc     1380

agtgccgggg tctggtctca ggacaagtgg aaggggaagt ttgatgtcca gtggattttt     1440

gttaaggatg tacccaataa ccagctccgg cacatcaggc tggagaataa cgacaacaaa     1500

ccggtcacaa actcccggga cacccaggag gtgcccttag aaaaagccaa gcaagtgctg     1560

aaaattatca gttcctacaa gcacacaacc tccatcttcg acgactttgc tcactacgag     1620

aagcgccagg aggaggagga ggtggtgcgc aaggaacggc agagtcgaaa caaacaatga     1680


<210> 16
<211> 290
<212> PRT
<213> Homo sapiens

<400> 16
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 17
<211> 873
<212> DNA
<213> Homo sapiens

<400> 17
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873


<210> 18
<211> 273
<212> PRT
<213> Homo sapiens

<400> 18
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210> 19
<211> 822
<212> DNA
<213> Homo sapiens

<400> 19
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta       60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg      120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa      180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg      240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac      300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa      360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag      420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt      480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg      540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg      600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact      660

tggctgcttc acattttcat ccccttctgc atcattgctt tcattttcat agccacagtg      720

atagccctaa gaaaacaact ctgtcaaaag ctgtattctt caaaagacac aacaaaaaga      780

cctgtcacca caacaaagag ggaagtgaac agtgctatct ga                         822


<210> 20
<211> 277
<212> PRT
<213> Homo sapiens

<400> 20
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210> 21
<211> 834
<212> DNA
<213> Homo sapiens

<400> 21
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccccaggat cggctgagag ccctggtggt gatccccatc      600

atcttcggga tcctgtttgc catcctcttg gtgctggtct ttatcaaaaa ggtggccaag      660

aagccaacca ataaggcccc ccaccccaag caggaacccc aggagatcaa ttttcccgac      720

gatcttcctg gctccaacac tgctgctcca gtgcaggaga ctttacatgg atgccaaccg      780

gtcacccagg aggatggcaa agagagtcgc atctcagtgc aggagagaca gtga            834


<210> 22
<211> 193
<212> PRT
<213> Homo sapiens

<400> 22
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210> 23
<211> 582
<212> DNA
<213> Homo sapiens

<400> 23
atgccggagg agggttcggg ctgctcggtg cggcgcaggc cctatgggtg cgtcctgcgg       60

gctgctttgg tcccattggt cgcgggcttg gtgatctgcc tcgtggtgtg catccagcgc      120

ttcgcacagg ctcagcagca gctgccgctc gagtcacttg ggtgggacgt agctgagctg      180

cagctgaatc acacaggacc tcagcaggac cccaggctat actggcaggg gggcccagca      240

ctgggccgct ccttcctgca tggaccagag ctggacaagg ggcagctacg tatccatcgt      300

gatggcatct acatggtaca catccaggtg acgctggcca tctgctcctc cacgacggcc      360

tccaggcacc accccaccac cctggccgtg ggaatctgct ctcccgcctc ccgtagcatc      420

agcctgctgc gtctcagctt ccaccaaggt tgtaccattg cctcccagcg cctgacgccc      480

ctggcccgag gggacacact ctgcaccaac ctcactggga cacttttgcc ttcccgaaac      540

actgatgaga ccttctttgg agtgcagtgg gtgcgcccct ga                         582


<210> 24
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 24
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Leu Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Lys Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 25
<211> 994
<212> PRT
<213> Staphylococcus agnetis

<400> 25
Met Asn Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Val Asp Ser Asp Thr Arg Glu Ile Lys Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Asp Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Asp 
    50                  55                  60                  


Arg Val Lys His Leu Leu Ala Glu Tyr Asn Leu Leu Asp Leu Thr Asn 
65                  70                  75                  80  


Ile Pro Lys Ser Thr Asn Pro Tyr Gln Ile Arg Val Lys Gly Leu Asn 
                85                  90                  95      


Glu Lys Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Asn Val Asn Val Met Met Asp Asp Asn Asp 
        115                 120                 125             


Ser Gly Asn Glu Leu Ser Thr Lys Asp Gln Leu Lys Lys Asn Ala Lys 
    130                 135                 140                 


Ala Leu Ser Asp Lys Tyr Val Cys Glu Leu Gln Leu Glu Arg Phe Glu 
145                 150                 155                 160 


Gln Asp Tyr Lys Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Glu Asp 
                165                 170                 175     


Phe Val Arg Glu Ala Arg Lys Leu Leu Glu Thr Gln Ser Lys Phe Phe 
            180                 185                 190         


Glu Ile Asp Gln Thr Phe Ile Met Arg Tyr Ile Asp Leu Val Glu Thr 
        195                 200                 205             


Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Phe Gly Trp 
    210                 215                 220                 


Glu Gly Asn Ile Lys Lys Trp Phe Glu Gln Met Met Gly His Cys Thr 
225                 230                 235                 240 


Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Glu 
                245                 250                 255     


Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp 
            260                 265                 270         


Glu Glu Ala Lys Leu Asn Tyr Gly Glu Lys Phe Gln Ile Ile Glu Asn 
        275                 280                 285             


Val Phe Lys Gln Lys Lys Thr Pro Asn Leu Lys Gln Ile Ala Lys Glu 
    290                 295                 300                 


Ile Gly Val Ser Glu Thr Asp Ile Lys Gly Tyr Arg Val Asn Lys Ser 
305                 310                 315                 320 


Gly Lys Pro Glu Phe Thr Gln Phe Lys Leu Tyr His Asp Leu Lys Asn 
                325                 330                 335     


Ile Phe Glu Asp Ser Lys Tyr Leu Asn Asp Val Gln Leu Met Asp Asn 
            340                 345                 350         


Ile Ala Glu Ile Ile Thr Ile Tyr Gln Asp Pro Glu Ser Ile Ile Lys 
        355                 360                 365             


Glu Leu Asn Gln Leu Pro Glu Leu Leu Ser Glu Lys Glu Lys Glu Lys 
    370                 375                 380                 


Ile Ser Ala Leu Ser Gly Tyr Ala Gly Thr His Arg Leu Ser Leu Lys 
385                 390                 395                 400 


Cys Ile Asn Leu Leu Leu Asp Asp Leu Trp Glu Ser Ser Leu Asn Gln 
                405                 410                 415     


Met Glu Leu Phe Thr Lys Leu Asn Leu Lys Pro Lys Lys Ile Asp Leu 
            420                 425                 430         


Ser Gln Gln His Lys Ile Pro Ile Lys Leu Val Asp Asp Phe Ile Leu 
        435                 440                 445             


Ser Pro Val Val Lys Arg Ala Phe Ile Gln Ser Ile Gln Val Val Asn 
    450                 455                 460                 


Ala Ile Ile Asp Lys Tyr Gly Leu Pro Glu Asp Ile Ile Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Asn Asn Ser Asp Asp Arg Arg Lys Phe Leu Asn Gln Leu 
                485                 490                 495     


Gln Lys Gln Asn Ala Glu Thr Arg Lys Gln Val Glu Lys Val Leu Arg 
            500                 505                 510         


Glu Tyr Gly Asn Asp Asn Ala Lys Arg Ile Val Gln Lys Ile Lys Leu 
        515                 520                 525             


His Asn Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Lys Asp Ile Pro 
    530                 535                 540                 


Leu Glu Asp Leu Leu Lys Asn Pro Asn His Tyr Glu Val Asp His Ile 
545                 550                 555                 560 


Ile Pro Arg Ser Val Ala Phe Asp Asn Ser Met His Asn Lys Val Leu 
                565                 570                 575     


Val Arg Ala Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Tyr Gln 
            580                 585                 590         


Tyr Leu Asn Ser Ser Glu Ser Ser Leu Ser Tyr Asn Glu Phe Lys Gln 
        595                 600                 605             


His Ile Leu Asn Leu Ser Lys Thr Lys Asp Arg Ile Thr Lys Lys Lys 
    610                 615                 620                 


Arg Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Tyr Asp Val Gln 
625                 630                 635                 640 


Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 
                645                 650                 655     


Glu Leu Thr Ser Leu Leu Lys Ala Tyr Phe Ser Ala Asn Asn Leu Asp 
            660                 665                 670         


Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asn Tyr Leu Arg Lys 
        675                 680                 685             


Val Trp Lys Phe Asp Lys Asp Arg Asn Lys Gly Tyr Lys His His Ala 
    690                 695                 700                 


Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys His Asn 
705                 710                 715                 720 


Lys Lys Leu Arg Asn Ile Asn Lys Val Leu Asp Ala Pro Ser Lys Glu 
                725                 730                 735     


Val Asp Lys Lys Arg Val Thr Val Gln Ser Glu Asp Glu Tyr Asn Gln 
            740                 745                 750         


Met Phe Glu Asp Thr Gln Lys Ala Gln Ala Ile Lys Lys Phe Glu Ile 
        755                 760                 765             


Arg Lys Phe Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile 
    770                 775                 780                 


Lys Asp Thr Leu Tyr Ser Thr Arg Asn Ile Asp Gly Ile Glu Tyr Val 
785                 790                 795                 800 


Val Glu Ser Ile Lys Asp Ile Tyr Ser Val Asn Asn Asp Lys Val Lys 
                805                 810                 815     


Thr Lys Phe Lys Lys Asp Pro His Arg Leu Leu Met Tyr Arg Asn Asp 
            820                 825                 830         


Pro Gln Thr Phe Glu Lys Phe Glu Lys Val Phe Lys Gln Tyr Glu Ser 
        835                 840                 845             


Glu Lys Asn Pro Phe Ala Lys Tyr Tyr Glu Glu Thr Gly Glu Lys Ile 
    850                 855                 860                 


Arg Lys Phe Ser Lys Thr Gly Gln Gly Pro Tyr Ile Asn Lys Ile Lys 
865                 870                 875                 880 


Tyr Leu Arg Glu Arg Leu Gly Arg His Cys Asp Val Thr Asn Lys Tyr 
                885                 890                 895     


Ile Asn Ser Arg Asn Lys Ile Val Gln Leu Lys Ile Tyr Ser Tyr Arg 
            900                 905                 910         


Phe Asp Ile Tyr Gln Tyr Gly Asn Asn Tyr Lys Met Ile Thr Ile Ser 
        915                 920                 925             


Tyr Ile Asp Leu Glu Gln Lys Ser Asn Tyr Tyr Tyr Ile Ser Arg Glu 
    930                 935                 940                 


Lys Tyr Glu Gln Lys Lys Lys Asp Lys Gln Ile Asp Asp Ser Tyr Lys 
945                 950                 955                 960 


Phe Ile Gly Ser Phe Tyr Lys Asn Asp Ile Ile Asn Tyr Asn Gly Glu 
                965                 970                 975     


Met Tyr Arg Val Ile Gly Val Asn Asp Ser Glu Lys Ile Lys Phe Ser 
            980                 985                 990         


Leu Ile 
        


<210> 26
<211> 1110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<223> Synthetic construct derived from Staphylococcus aureus Cas9

<400> 26
Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
            20                  25                  30          


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
        35                  40                  45              


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
    50                  55                  60                  


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
65                  70                  75                  80  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
                85                  90                  95      


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
            100                 105                 110         


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
        115                 120                 125             


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
    130                 135                 140                 


Gly Asn Glu Leu Ser Thr Arg Glu Gln Ile Ser Arg Asn Ser Lys Ala 
145                 150                 155                 160 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
                165                 170                 175     


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
            180                 185                 190         


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
        195                 200                 205             


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
    210                 215                 220                 


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
225                 230                 235                 240 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
                245                 250                 255     


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
            260                 265                 270         


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
        275                 280                 285             


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
    290                 295                 300                 


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
305                 310                 315                 320 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
                325                 330                 335     


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
            340                 345                 350         


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
        355                 360                 365             


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
    370                 375                 380                 


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
385                 390                 395                 400 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
                405                 410                 415     


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
            420                 425                 430         


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
        435                 440                 445             


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
    450                 455                 460                 


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
                485                 490                 495     


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
            500                 505                 510         


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
        515                 520                 525             


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
    530                 535                 540                 


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
                565                 570                 575     


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
            580                 585                 590         


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
        595                 600                 605             


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
    610                 615                 620                 


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
625                 630                 635                 640 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
                645                 650                 655     


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
            660                 665                 670         


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
        675                 680                 685             


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
    690                 695                 700                 


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
705                 710                 715                 720 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
                725                 730                 735     


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Arg 
            740                 745                 750         


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
        755                 760                 765             


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
    770                 775                 780                 


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
785                 790                 795                 800 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
                805                 810                 815     


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
            820                 825                 830         


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
        835                 840                 845             


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
    850                 855                 860                 


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
865                 870                 875                 880 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
                885                 890                 895     


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
            900                 905                 910         


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
        915                 920                 925             


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
    930                 935                 940                 


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
945                 950                 955                 960 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
                965                 970                 975     


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
            980                 985                 990         


Glu Leu Tyr Arg Val Ile Gly Val  Asn Asn Asp Leu Leu  Asn Arg Ile 
        995                 1000                 1005             


Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
    1010                 1015                 1020             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1025                 1030                 1035             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1040                 1045                 1050             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1055                 1060                 1065             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1070                 1075                 1080             


Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Ser Gly 
    1085                 1090                 1095             


Phe Ala  Asn Glu Leu Gly Pro  Arg Leu Met Gly Lys  
    1100                 1105                 1110 


<210> 27
<211> 1235
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Candidatus Methanomethylophilus alvus sequence"

<400> 27
Met His Thr Gly Gly Leu Leu Ser Met Asp Ala Lys Glu Phe Thr Gly 
1               5                   10                  15      


Gln Tyr Pro Leu Ser Lys Thr Leu Arg Phe Glu Leu Arg Pro Ile Gly 
            20                  25                  30          


Arg Thr Trp Asp Asn Leu Glu Ala Ser Gly Tyr Leu Ala Glu Asp Arg 
        35                  40                  45              


His Arg Ala Glu Cys Tyr Pro Arg Ala Lys Glu Leu Leu Asp Asp Asn 
    50                  55                  60                  


His Arg Ala Phe Leu Asn Arg Val Leu Pro Gln Ile Asp Met Asp Trp 
65                  70                  75                  80  


His Pro Ile Ala Glu Ala Phe Cys Lys Val His Lys Asn Pro Gly Asn 
                85                  90                  95      


Lys Glu Leu Ala Gln Asp Tyr Asn Leu Gln Leu Ser Lys Arg Arg Lys 
            100                 105                 110         


Glu Ile Ser Ala Tyr Leu Gln Asp Ala Asp Gly Tyr Lys Gly Leu Phe 
        115                 120                 125             


Ala Lys Pro Ala Leu Asp Glu Ala Met Lys Ile Ala Lys Glu Asn Gly 
    130                 135                 140                 


Asn Glu Ser Asp Ile Glu Val Leu Glu Ala Phe Asn Gly Phe Ser Val 
145                 150                 155                 160 


Tyr Phe Thr Gly Tyr His Glu Ser Arg Glu Asn Ile Tyr Ser Asp Glu 
                165                 170                 175     


Asp Met Val Ser Val Ala Tyr Arg Ile Thr Glu Asp Asn Phe Pro Arg 
            180                 185                 190         


Phe Val Ser Asn Ala Leu Ile Phe Asp Lys Leu Asn Glu Ser His Pro 
        195                 200                 205             


Asp Ile Ile Ser Glu Val Ser Gly Asn Leu Gly Val Asp Asp Ile Gly 
    210                 215                 220                 


Lys Tyr Phe Asp Val Ser Asn Tyr Asn Asn Phe Leu Ser Gln Ala Gly 
225                 230                 235                 240 


Ile Asp Asp Tyr Asn His Ile Ile Gly Gly His Thr Thr Glu Asp Gly 
                245                 250                 255     


Leu Ile Gln Ala Phe Asn Val Val Leu Asn Leu Arg His Gln Lys Asp 
            260                 265                 270         


Pro Gly Phe Glu Lys Ile Gln Phe Lys Gln Leu Tyr Lys Gln Ile Leu 
        275                 280                 285             


Ser Val Arg Thr Ser Lys Ser Tyr Ile Pro Lys Gln Phe Asp Asn Ser 
    290                 295                 300                 


Lys Glu Met Val Asp Cys Ile Cys Asp Tyr Val Ser Lys Ile Glu Lys 
305                 310                 315                 320 


Ser Glu Thr Val Glu Arg Ala Leu Lys Leu Val Arg Asn Ile Ser Ser 
                325                 330                 335     


Phe Asp Leu Arg Gly Ile Phe Val Asn Lys Lys Asn Leu Arg Ile Leu 
            340                 345                 350         


Ser Asn Lys Leu Ile Gly Asp Trp Asp Ala Ile Glu Thr Ala Leu Met 
        355                 360                 365             


His Ser Ser Ser Ser Glu Asn Asp Lys Lys Ser Val Tyr Asp Ser Ala 
    370                 375                 380                 


Glu Ala Phe Thr Leu Asp Asp Ile Phe Ser Ser Val Lys Lys Phe Ser 
385                 390                 395                 400 


Asp Ala Ser Ala Glu Asp Ile Gly Asn Arg Ala Glu Asp Ile Cys Arg 
                405                 410                 415     


Val Ile Ser Glu Thr Ala Pro Phe Ile Asn Asp Leu Arg Ala Val Asp 
            420                 425                 430         


Leu Asp Ser Leu Asn Asp Asp Gly Tyr Glu Ala Ala Val Ser Lys Ile 
        435                 440                 445             


Arg Glu Ser Leu Glu Pro Tyr Met Asp Leu Phe His Glu Leu Glu Ile 
    450                 455                 460                 


Phe Ser Val Gly Asp Glu Phe Pro Lys Cys Ala Ala Phe Tyr Ser Glu 
465                 470                 475                 480 


Leu Glu Glu Val Ser Glu Gln Leu Ile Glu Ile Ile Pro Leu Phe Asn 
                485                 490                 495     


Lys Ala Arg Ser Phe Cys Thr Arg Lys Arg Tyr Ser Thr Asp Lys Ile 
            500                 505                 510         


Lys Val Asn Leu Lys Phe Pro Thr Leu Ala Asp Gly Trp Asp Leu Asn 
        515                 520                 525             


Lys Glu Arg Asp Asn Lys Ala Ala Ile Leu Arg Lys Asp Gly Lys Tyr 
    530                 535                 540                 


Tyr Leu Ala Ile Leu Asp Met Lys Lys Asp Leu Ser Ser Ile Arg Thr 
545                 550                 555                 560 


Ser Asp Glu Asp Glu Ser Ser Phe Glu Lys Met Glu Tyr Lys Leu Leu 
                565                 570                 575     


Pro Ser Pro Val Lys Met Leu Pro Lys Ile Phe Val Lys Ser Lys Ala 
            580                 585                 590         


Ala Lys Glu Lys Tyr Gly Leu Thr Asp Arg Met Leu Glu Cys Tyr Asp 
        595                 600                 605             


Lys Gly Met His Lys Ser Gly Ser Ala Phe Asp Leu Gly Phe Cys His 
    610                 615                 620                 


Glu Leu Ile Asp Tyr Tyr Lys Arg Cys Ile Ala Glu Tyr Pro Gly Trp 
625                 630                 635                 640 


Asp Val Phe Asp Phe Lys Phe Arg Glu Thr Ser Asp Tyr Gly Ser Met 
                645                 650                 655     


Lys Glu Phe Asn Glu Asp Val Ala Gly Ala Gly Tyr Tyr Met Ser Leu 
            660                 665                 670         


Arg Lys Ile Pro Cys Ser Glu Val Tyr Arg Leu Leu Asp Glu Lys Ser 
        675                 680                 685             


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Tyr Ser Glu Asn Ala His 
    690                 695                 700                 


Gly Asn Lys Asn Met His Thr Met Tyr Trp Glu Gly Leu Phe Ser Pro 
705                 710                 715                 720 


Gln Asn Leu Glu Ser Pro Val Phe Lys Leu Ser Gly Gly Ala Glu Leu 
                725                 730                 735     


Phe Phe Arg Lys Ser Ser Ile Pro Asn Asp Ala Lys Thr Val His Pro 
            740                 745                 750         


Lys Gly Ser Val Leu Val Pro Arg Asn Asp Val Asn Gly Arg Arg Ile 
        755                 760                 765             


Pro Asp Ser Ile Tyr Arg Glu Leu Thr Arg Tyr Phe Asn Arg Gly Asp 
    770                 775                 780                 


Cys Arg Ile Ser Asp Glu Ala Lys Ser Tyr Leu Asp Lys Val Lys Thr 
785                 790                 795                 800 


Lys Lys Ala Asp His Asp Ile Val Lys Asp Arg Arg Phe Thr Val Asp 
                805                 810                 815     


Lys Met Met Phe His Val Pro Ile Ala Met Asn Phe Lys Ala Ile Ser 
            820                 825                 830         


Lys Pro Asn Leu Asn Lys Lys Val Ile Asp Gly Ile Ile Asp Asp Gln 
        835                 840                 845             


Asp Leu Lys Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr 
    850                 855                 860                 


Val Thr Met Val Asp Arg Lys Gly Asn Ile Leu Tyr Gln Asp Ser Leu 
865                 870                 875                 880 


Asn Ile Leu Asn Gly Tyr Asp Tyr Arg Lys Ala Leu Asp Val Arg Glu 
                885                 890                 895     


Tyr Asp Asn Lys Glu Ala Arg Arg Asn Trp Thr Lys Val Glu Gly Ile 
            900                 905                 910         


Arg Lys Met Lys Glu Gly Tyr Leu Ser Leu Ala Val Ser Lys Leu Ala 
        915                 920                 925             


Asp Met Ile Ile Glu Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn 
    930                 935                 940                 


His Gly Phe Lys Ala Gly Arg Ser Lys Ile Glu Lys Gln Val Tyr Gln 
945                 950                 955                 960 


Lys Phe Glu Ser Met Leu Ile Asn Lys Leu Gly Tyr Met Val Leu Lys 
                965                 970                 975     


Asp Lys Ser Ile Asp Gln Ser Gly Gly Ala Leu His Gly Tyr Gln Leu 
            980                 985                 990         


Ala Asn His Val Thr Thr Leu Ala  Ser Val Gly Lys Gln  Cys Gly Val 
        995                 1000                 1005             


Ile Phe  Tyr Ile Pro Ala Ala  Phe Thr Ser Lys Ile  Asp Pro Thr 
    1010                 1015                 1020             


Thr Gly  Phe Ala Asp Leu Phe  Ala Leu Ser Asn Val  Lys Asn Val 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Phe Phe  Ser Lys Met Lys Ser  Val Ile Tyr 
    1040                 1045                 1050             


Asp Lys  Ala Glu Gly Lys Phe  Ala Phe Thr Phe Asp  Tyr Leu Asp 
    1055                 1060                 1065             


Tyr Asn  Val Lys Ser Glu Cys  Gly Arg Thr Leu Trp  Thr Val Tyr 
    1070                 1075                 1080             


Thr Val  Gly Glu Arg Phe Thr  Tyr Ser Arg Val Asn  Arg Glu Tyr 
    1085                 1090                 1095             


Val Arg  Lys Val Pro Thr Asp  Ile Ile Tyr Asp Ala  Leu Gln Lys 
    1100                 1105                 1110             


Ala Gly  Ile Ser Val Glu Gly  Asp Leu Arg Asp Arg  Ile Ala Glu 
    1115                 1120                 1125             


Ser Asp  Gly Asp Thr Leu Lys  Ser Ile Phe Tyr Ala  Phe Lys Tyr 
    1130                 1135                 1140             


Ala Leu  Asp Met Arg Val Glu  Asn Arg Glu Glu Asp  Tyr Ile Gln 
    1145                 1150                 1155             


Ser Pro  Val Lys Asn Ala Ser  Gly Glu Phe Phe Cys  Ser Lys Asn 
    1160                 1165                 1170             


Ala Gly  Lys Ser Leu Pro Gln  Asp Ser Asp Ala Asn  Gly Ala Tyr 
    1175                 1180                 1185             


Asn Ile  Ala Leu Lys Gly Ile  Leu Gln Leu Arg Met  Leu Ser Glu 
    1190                 1195                 1200             


Gln Tyr  Asp Pro Asn Ala Glu  Ser Ile Arg Leu Pro  Leu Ile Thr 
    1205                 1210                 1215             


Asn Lys  Ala Trp Leu Thr Phe  Met Gln Ser Gly Met  Lys Thr Trp 
    1220                 1225                 1230             


Lys Asn  
    1235 


<210> 28
<211> 1227
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Candidatus Methanomethylophilus alvus sequence"

<400> 28
Met Asp Ala Lys Glu Phe Thr Gly Gln Tyr Pro Leu Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Arg Pro Ile Gly Arg Thr Trp Asp Asn Leu Glu Ala 
            20                  25                  30          


Ser Gly Tyr Leu Ala Glu Asp Arg His Arg Ala Glu Cys Tyr Pro Arg 
        35                  40                  45              


Ala Lys Glu Leu Leu Asp Asp Asn His Arg Ala Phe Leu Asn Arg Val 
    50                  55                  60                  


Leu Pro Gln Ile Asp Met Asp Trp His Pro Ile Ala Glu Ala Phe Cys 
65                  70                  75                  80  


Lys Val His Lys Asn Pro Gly Asn Lys Glu Leu Ala Gln Asp Tyr Asn 
                85                  90                  95      


Leu Gln Leu Ser Lys Arg Arg Lys Glu Ile Ser Ala Tyr Leu Gln Asp 
            100                 105                 110         


Ala Asp Gly Tyr Lys Gly Leu Phe Ala Lys Pro Ala Leu Asp Glu Ala 
        115                 120                 125             


Met Lys Ile Ala Lys Glu Asn Gly Asn Glu Ser Asp Ile Glu Val Leu 
    130                 135                 140                 


Glu Ala Phe Asn Gly Phe Ser Val Tyr Phe Thr Gly Tyr His Glu Ser 
145                 150                 155                 160 


Arg Glu Asn Ile Tyr Ser Asp Glu Asp Met Val Ser Val Ala Tyr Arg 
                165                 170                 175     


Ile Thr Glu Asp Asn Phe Pro Arg Phe Val Ser Asn Ala Leu Ile Phe 
            180                 185                 190         


Asp Lys Leu Asn Glu Ser His Pro Asp Ile Ile Ser Glu Val Ser Gly 
        195                 200                 205             


Asn Leu Gly Val Asp Asp Ile Gly Lys Tyr Phe Asp Val Ser Asn Tyr 
    210                 215                 220                 


Asn Asn Phe Leu Ser Gln Ala Gly Ile Asp Asp Tyr Asn His Ile Ile 
225                 230                 235                 240 


Gly Gly His Thr Thr Glu Asp Gly Leu Ile Gln Ala Phe Asn Val Val 
                245                 250                 255     


Leu Asn Leu Arg His Gln Lys Asp Pro Gly Phe Glu Lys Ile Gln Phe 
            260                 265                 270         


Lys Gln Leu Tyr Lys Gln Ile Leu Ser Val Arg Thr Ser Lys Ser Tyr 
        275                 280                 285             


Ile Pro Lys Gln Phe Asp Asn Ser Lys Glu Met Val Asp Cys Ile Cys 
    290                 295                 300                 


Asp Tyr Val Ser Lys Ile Glu Lys Ser Glu Thr Val Glu Arg Ala Leu 
305                 310                 315                 320 


Lys Leu Val Arg Asn Ile Ser Ser Phe Asp Leu Arg Gly Ile Phe Val 
                325                 330                 335     


Asn Lys Lys Asn Leu Arg Ile Leu Ser Asn Lys Leu Ile Gly Asp Trp 
            340                 345                 350         


Asp Ala Ile Glu Thr Ala Leu Met His Ser Ser Ser Ser Glu Asn Asp 
        355                 360                 365             


Lys Lys Ser Val Tyr Asp Ser Ala Glu Ala Phe Thr Leu Asp Asp Ile 
    370                 375                 380                 


Phe Ser Ser Val Lys Lys Phe Ser Asp Ala Ser Ala Glu Asp Ile Gly 
385                 390                 395                 400 


Asn Arg Ala Glu Asp Ile Cys Arg Val Ile Ser Glu Thr Ala Pro Phe 
                405                 410                 415     


Ile Asn Asp Leu Arg Ala Val Asp Leu Asp Ser Leu Asn Asp Asp Gly 
            420                 425                 430         


Tyr Glu Ala Ala Val Ser Lys Ile Arg Glu Ser Leu Glu Pro Tyr Met 
        435                 440                 445             


Asp Leu Phe His Glu Leu Glu Ile Phe Ser Val Gly Asp Glu Phe Pro 
    450                 455                 460                 


Lys Cys Ala Ala Phe Tyr Ser Glu Leu Glu Glu Val Ser Glu Gln Leu 
465                 470                 475                 480 


Ile Glu Ile Ile Pro Leu Phe Asn Lys Ala Arg Ser Phe Cys Thr Arg 
                485                 490                 495     


Lys Arg Tyr Ser Thr Asp Lys Ile Lys Val Asn Leu Lys Phe Pro Thr 
            500                 505                 510         


Leu Ala Asp Gly Trp Asp Leu Asn Lys Glu Arg Asp Asn Lys Ala Ala 
        515                 520                 525             


Ile Leu Arg Lys Asp Gly Lys Tyr Tyr Leu Ala Ile Leu Asp Met Lys 
    530                 535                 540                 


Lys Asp Leu Ser Ser Ile Arg Thr Ser Asp Glu Asp Glu Ser Ser Phe 
545                 550                 555                 560 


Glu Lys Met Glu Tyr Lys Leu Leu Pro Ser Pro Val Lys Met Leu Pro 
                565                 570                 575     


Lys Ile Phe Val Lys Ser Lys Ala Ala Lys Glu Lys Tyr Gly Leu Thr 
            580                 585                 590         


Asp Arg Met Leu Glu Cys Tyr Asp Lys Gly Met His Lys Ser Gly Ser 
        595                 600                 605             


Ala Phe Asp Leu Gly Phe Cys His Glu Leu Ile Asp Tyr Tyr Lys Arg 
    610                 615                 620                 


Cys Ile Ala Glu Tyr Pro Gly Trp Asp Val Phe Asp Phe Lys Phe Arg 
625                 630                 635                 640 


Glu Thr Ser Asp Tyr Gly Ser Met Lys Glu Phe Asn Glu Asp Val Ala 
                645                 650                 655     


Gly Ala Gly Tyr Tyr Met Ser Leu Arg Lys Ile Pro Cys Ser Glu Val 
            660                 665                 670         


Tyr Arg Leu Leu Asp Glu Lys Ser Ile Tyr Leu Phe Gln Ile Tyr Asn 
        675                 680                 685             


Lys Asp Tyr Ser Glu Asn Ala His Gly Asn Lys Asn Met His Thr Met 
    690                 695                 700                 


Tyr Trp Glu Gly Leu Phe Ser Pro Gln Asn Leu Glu Ser Pro Val Phe 
705                 710                 715                 720 


Lys Leu Ser Gly Gly Ala Glu Leu Phe Phe Arg Lys Ser Ser Ile Pro 
                725                 730                 735     


Asn Asp Ala Lys Thr Val His Pro Lys Gly Ser Val Leu Val Pro Arg 
            740                 745                 750         


Asn Asp Val Asn Gly Arg Arg Ile Pro Asp Ser Ile Tyr Arg Glu Leu 
        755                 760                 765             


Thr Arg Tyr Phe Asn Arg Gly Asp Cys Arg Ile Ser Asp Glu Ala Lys 
    770                 775                 780                 


Ser Tyr Leu Asp Lys Val Lys Thr Lys Lys Ala Asp His Asp Ile Val 
785                 790                 795                 800 


Lys Asp Arg Arg Phe Thr Val Asp Lys Met Met Phe His Val Pro Ile 
                805                 810                 815     


Ala Met Asn Phe Lys Ala Ile Ser Lys Pro Asn Leu Asn Lys Lys Val 
            820                 825                 830         


Ile Asp Gly Ile Ile Asp Asp Gln Asp Leu Lys Ile Ile Gly Ile Asp 
        835                 840                 845             


Arg Gly Glu Arg Asn Leu Ile Tyr Val Thr Met Val Asp Arg Lys Gly 
    850                 855                 860                 


Asn Ile Leu Tyr Gln Asp Ser Leu Asn Ile Leu Asn Gly Tyr Asp Tyr 
865                 870                 875                 880 


Arg Lys Ala Leu Asp Val Arg Glu Tyr Asp Asn Lys Glu Ala Arg Arg 
                885                 890                 895     


Asn Trp Thr Lys Val Glu Gly Ile Arg Lys Met Lys Glu Gly Tyr Leu 
            900                 905                 910         


Ser Leu Ala Val Ser Lys Leu Ala Asp Met Ile Ile Glu Asn Asn Ala 
        915                 920                 925             


Ile Ile Val Met Glu Asp Leu Asn His Gly Phe Lys Ala Gly Arg Ser 
    930                 935                 940                 


Lys Ile Glu Lys Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn 
945                 950                 955                 960 


Lys Leu Gly Tyr Met Val Leu Lys Asp Lys Ser Ile Asp Gln Ser Gly 
                965                 970                 975     


Gly Ala Leu His Gly Tyr Gln Leu Ala Asn His Val Thr Thr Leu Ala 
            980                 985                 990         


Ser Val Gly Lys Gln Cys Gly Val  Ile Phe Tyr Ile Pro  Ala Ala Phe 
        995                 1000                 1005             


Thr Ser  Lys Ile Asp Pro Thr  Thr Gly Phe Ala Asp  Leu Phe Ala 
    1010                 1015                 1020             


Leu Ser  Asn Val Lys Asn Val  Ala Ser Met Arg Glu  Phe Phe Ser 
    1025                 1030                 1035             


Lys Met  Lys Ser Val Ile Tyr  Asp Lys Ala Glu Gly  Lys Phe Ala 
    1040                 1045                 1050             


Phe Thr  Phe Asp Tyr Leu Asp  Tyr Asn Val Lys Ser  Glu Cys Gly 
    1055                 1060                 1065             


Arg Thr  Leu Trp Thr Val Tyr  Thr Val Gly Glu Arg  Phe Thr Tyr 
    1070                 1075                 1080             


Ser Arg  Val Asn Arg Glu Tyr  Val Arg Lys Val Pro  Thr Asp Ile 
    1085                 1090                 1095             


Ile Tyr  Asp Ala Leu Gln Lys  Ala Gly Ile Ser Val  Glu Gly Asp 
    1100                 1105                 1110             


Leu Arg  Asp Arg Ile Ala Glu  Ser Asp Gly Asp Thr  Leu Lys Ser 
    1115                 1120                 1125             


Ile Phe  Tyr Ala Phe Lys Tyr  Ala Leu Asp Met Arg  Val Glu Asn 
    1130                 1135                 1140             


Arg Glu  Glu Asp Tyr Ile Gln  Ser Pro Val Lys Asn  Ala Ser Gly 
    1145                 1150                 1155             


Glu Phe  Phe Cys Ser Lys Asn  Ala Gly Lys Ser Leu  Pro Gln Asp 
    1160                 1165                 1170             


Ser Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Lys  Gly Ile Leu 
    1175                 1180                 1185             


Gln Leu  Arg Met Leu Ser Glu  Gln Tyr Asp Pro Asn  Ala Glu Ser 
    1190                 1195                 1200             


Ile Arg  Leu Pro Leu Ile Thr  Asn Lys Ala Trp Leu  Thr Phe Met 
    1205                 1210                 1215             


Gln Ser  Gly Met Lys Thr Trp  Lys Asn 
    1220                 1225         


<210> 29
<211> 1238
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Candidatus Methanoplasma termitum sequence"

<400> 29
Met Asn Asn Tyr Asp Glu Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Met Glu His Leu Glu 
            20                  25                  30          


Thr Phe Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Ala Ile Asp Glu Tyr His Lys Lys Phe Ile Asp Glu 
    50                  55                  60                  


His Leu Thr Asn Met Ser Leu Asp Trp Asn Ser Leu Lys Gln Ile Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Lys Ser Arg Glu Glu Lys Asp Lys Lys Val Phe Leu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Arg Gln Glu Ile Val Ser Glu Phe Lys Lys 
            100                 105                 110         


Asp Asp Arg Phe Lys Asp Leu Phe Ser Lys Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Lys Glu Glu Ile Tyr Lys Lys Gly Asn His Gln Glu Ile Asp Ala 
    130                 135                 140                 


Leu Lys Ser Phe Asp Lys Phe Ser Gly Tyr Phe Ile Gly Leu His Glu 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Asp Gly Asp Glu Ile Thr Ala Ile Ser 
                165                 170                 175     


Asn Arg Ile Val Asn Glu Asn Phe Pro Lys Phe Leu Asp Asn Leu Gln 
            180                 185                 190         


Lys Tyr Gln Glu Ala Arg Lys Lys Tyr Pro Glu Trp Ile Ile Lys Ala 
        195                 200                 205             


Glu Ser Ala Leu Val Ala His Asn Ile Lys Met Asp Glu Val Phe Ser 
    210                 215                 220                 


Leu Glu Tyr Phe Asn Lys Val Leu Asn Gln Glu Gly Ile Gln Arg Tyr 
225                 230                 235                 240 


Asn Leu Ala Leu Gly Gly Tyr Val Thr Lys Ser Gly Glu Lys Met Met 
                245                 250                 255     


Gly Leu Asn Asp Ala Leu Asn Leu Ala His Gln Ser Glu Lys Ser Ser 
            260                 265                 270         


Lys Gly Arg Ile His Met Thr Pro Leu Phe Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Glu Ser Phe Ser Tyr Ile Pro Asp Val Phe Thr Glu Asp Ser Gln 
    290                 295                 300                 


Leu Leu Pro Ser Ile Gly Gly Phe Phe Ala Gln Ile Glu Asn Asp Lys 
305                 310                 315                 320 


Asp Gly Asn Ile Phe Asp Arg Ala Leu Glu Leu Ile Ser Ser Tyr Ala 
                325                 330                 335     


Glu Tyr Asp Thr Glu Arg Ile Tyr Ile Arg Gln Ala Asp Ile Asn Arg 
            340                 345                 350         


Val Ser Asn Val Ile Phe Gly Glu Trp Gly Thr Leu Gly Gly Leu Met 
        355                 360                 365             


Arg Glu Tyr Lys Ala Asp Ser Ile Asn Asp Ile Asn Leu Glu Arg Thr 
    370                 375                 380                 


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Lys Glu Phe Ala Leu Ser 
385                 390                 395                 400 


Asp Val Leu Glu Ala Ile Lys Arg Thr Gly Asn Asn Asp Ala Phe Asn 
                405                 410                 415     


Glu Tyr Ile Ser Lys Met Arg Thr Ala Arg Glu Lys Ile Asp Ala Ala 
            420                 425                 430         


Arg Lys Glu Met Lys Phe Ile Ser Glu Lys Ile Ser Gly Asp Glu Glu 
        435                 440                 445             


Ser Ile His Ile Ile Lys Thr Leu Leu Asp Ser Val Gln Gln Phe Leu 
    450                 455                 460                 


His Phe Phe Asn Leu Phe Lys Ala Arg Gln Asp Ile Pro Leu Asp Gly 
465                 470                 475                 480 


Ala Phe Tyr Ala Glu Phe Asp Glu Val His Ser Lys Leu Phe Ala Ile 
                485                 490                 495     


Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Lys Asn Asn Leu 
            500                 505                 510         


Asn Thr Lys Lys Ile Lys Leu Asn Phe Lys Asn Pro Thr Leu Ala Asn 
        515                 520                 525             


Gly Trp Asp Gln Asn Lys Val Tyr Asp Tyr Ala Ser Leu Ile Phe Leu 
    530                 535                 540                 


Arg Asp Gly Asn Tyr Tyr Leu Gly Ile Ile Asn Pro Lys Arg Lys Lys 
545                 550                 555                 560 


Asn Ile Lys Phe Glu Gln Gly Ser Gly Asn Gly Pro Phe Tyr Arg Lys 
                565                 570                 575     


Met Val Tyr Lys Gln Ile Pro Gly Pro Asn Lys Asn Leu Pro Arg Val 
            580                 585                 590         


Phe Leu Thr Ser Thr Lys Gly Lys Lys Glu Tyr Lys Pro Ser Lys Glu 
        595                 600                 605             


Ile Ile Glu Gly Tyr Glu Ala Asp Lys His Ile Arg Gly Asp Lys Phe 
    610                 615                 620                 


Asp Leu Asp Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
625                 630                 635                 640 


Glu Lys His Lys Asp Trp Ser Lys Phe Asn Phe Tyr Phe Ser Pro Thr 
                645                 650                 655     


Glu Ser Tyr Gly Asp Ile Ser Glu Phe Tyr Leu Asp Val Glu Lys Gln 
            660                 665                 670         


Gly Tyr Arg Met His Phe Glu Asn Ile Ser Ala Glu Thr Ile Asp Glu 
        675                 680                 685             


Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
    690                 695                 700                 


Phe Val Lys Ala Ala Thr Gly Lys Lys Asp Met His Thr Ile Tyr Trp 
705                 710                 715                 720 


Asn Ala Ala Phe Ser Pro Glu Asn Leu Gln Asp Val Val Val Lys Leu 
                725                 730                 735     


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp Lys Ser Asp Ile Lys Glu 
            740                 745                 750         


Ile Val His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Asn Gly 
        755                 760                 765             


Arg Thr Pro Val Pro Asp Lys Ile His Lys Lys Leu Thr Asp Tyr His 
    770                 775                 780                 


Asn Gly Arg Thr Lys Asp Leu Gly Glu Ala Lys Glu Tyr Leu Asp Lys 
785                 790                 795                 800 


Val Arg Tyr Phe Lys Ala His Tyr Asp Ile Thr Lys Asp Arg Arg Tyr 
                805                 810                 815     


Leu Asn Asp Lys Ile Tyr Phe His Val Pro Leu Thr Leu Asn Phe Lys 
            820                 825                 830         


Ala Asn Gly Lys Lys Asn Leu Asn Lys Met Val Ile Glu Lys Phe Leu 
        835                 840                 845             


Ser Asp Glu Lys Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Ser Gly Lys Ile Ile Asp Gln 
865                 870                 875                 880 


Gln Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr Arg Glu Lys Leu Asn 
                885                 890                 895     


Gln Arg Glu Ile Glu Met Lys Asp Ala Arg Gln Ser Trp Asn Ala Ile 
            900                 905                 910         


Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Lys Ala Val His 
        915                 920                 925             


Glu Ile Thr Lys Met Ala Ile Gln Tyr Asn Ala Ile Val Val Met Glu 
    930                 935                 940                 


Glu Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Phe Glu Asn Met Leu Ile Asp Lys Met Asn Tyr Leu 
                965                 970                 975     


Val Phe Lys Asp Ala Pro Asp Glu Ser Pro Gly Gly Val Leu Asn Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Pro Leu Glu  Ser Phe Ala Lys Leu  Gly Lys Gln 
        995                 1000                 1005             


Thr Gly  Ile Leu Phe Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile 
    1010                 1015                 1020             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Thr  Ser Ser Lys 
    1025                 1030                 1035             


Thr Asn  Ala Gln Glu Arg Lys  Glu Phe Leu Gln Lys  Phe Glu Ser 
    1040                 1045                 1050             


Ile Ser  Tyr Ser Ala Lys Asp  Gly Gly Ile Phe Ala  Phe Ala Phe 
    1055                 1060                 1065             


Asp Tyr  Arg Lys Phe Gly Thr  Ser Lys Thr Asp His  Lys Asn Val 
    1070                 1075                 1080             


Trp Thr  Ala Tyr Thr Asn Gly  Glu Arg Met Arg Tyr  Ile Lys Glu 
    1085                 1090                 1095             


Lys Lys  Arg Asn Glu Leu Phe  Asp Pro Ser Lys Glu  Ile Lys Glu 
    1100                 1105                 1110             


Ala Leu  Thr Ser Ser Gly Ile  Lys Tyr Asp Gly Gly  Gln Asn Ile 
    1115                 1120                 1125             


Leu Pro  Asp Ile Leu Arg Ser  Asn Asn Asn Gly Leu  Ile Tyr Thr 
    1130                 1135                 1140             


Met Tyr  Ser Ser Phe Ile Ala  Ala Ile Gln Met Arg  Val Tyr Asp 
    1145                 1150                 1155             


Gly Lys  Glu Asp Tyr Ile Ile  Ser Pro Ile Lys Asn  Ser Lys Gly 
    1160                 1165                 1170             


Glu Phe  Phe Arg Thr Asp Pro  Lys Arg Arg Glu Leu  Pro Ile Asp 
    1175                 1180                 1185             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Arg  Gly Glu Leu 
    1190                 1195                 1200             


Thr Met  Arg Ala Ile Ala Glu  Lys Phe Asp Pro Asp  Ser Glu Lys 
    1205                 1210                 1215             


Met Ala  Lys Leu Glu Leu Lys  His Lys Asp Trp Phe  Glu Phe Met 
    1220                 1225                 1230             


Gln Thr  Arg Gly Asp 
    1235             


<210> 30
<211> 1273
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<223> COVID19 variant

<400> 30
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Ile Ser Tyr Leu Thr Pro Gly Gly Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Lys Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Arg Phe Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Pro Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210> 31
<211> 3819
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<223> COVID19 variant DNA

<400> 31
atgtttgtgt ttctggtgct gctgccgctg gtgagcagcc agtgcgtgaa ctttaccacc       60

cgcacccagc tgccgccggc gtataccaac agctttaccc gcggcgtgta ttatccggat      120

aaagtgtttc gcagcagcgt gctgcatagc acccaggatc tgtttctgcc gttttttagc      180

aacgtgacct ggtttcatgc gattcatgtg agcggcacca acggcaccaa acgctttgat      240

aacccggtgc tgccgtttaa cgatggcgtg tattttgcga gcaccgaaaa aagcaacatt      300

attcgcggct ggatttttgg caccaccctg gatagcaaaa cccagagcct gctgattgtg      360

aacaacgcga ccaacgtggt gattaaagtg tgcgaatttc agttttgcaa cgatccgttt      420

ctgggcgtgt attatcataa aaacaacaaa agctggatgg aaagcgaatt tcgcgtgtat      480

agcagcgcga acaactgcac ctttgaatat gtgagccagc cgtttctgat ggatctggaa      540

ggcaaacagg gcaactttaa aaacctgcgc gaatttgtgt ttaaaaacat tgatggctat      600

tttaaaattt atagcaaaca taccccgatt aacctggtgc gcgatctgcc gcagggcttt      660

agcgcgctgg aaccgctggt ggatctgccg attggcatta acattacccg ctttcagacc      720

ctgctggcgc tgcatattag ctatctgacc ccgggcggca gcagcagcgg ctggaccgcg      780

ggcgcggcgg cgtattatgt gggctatctg cagccgcgca cctttctgct gaaatataac      840

gaaaacggca ccattaccga tgcggtggat tgcgcgctgg atccgctgag cgaaaccaaa      900

tgcaccctga aaagctttac cgtggaaaaa ggcatttatc agaccagcaa ctttcgcgtg      960

cagccgaccg aaagcattgt gcgctttccg aacattacca acctgtgccc gtttggcgaa     1020

gtgtttaacg cgacccgctt tgcgagcgtg tatgcgtgga accgcaaacg cattagcaac     1080

tgcgtggcgg attatagcgt gctgtataac agcgcgagct ttagcacctt taaatgctat     1140

ggcgtgagcc cgaccaaact gaacgatctg tgctttacca acgtgtatgc ggatagcttt     1200

gtgattcgcg gcgatgaagt gcgccagatt gcgccgggcc agaccggcaa cattgcggat     1260

tataactata aactgccgga tgattttacc ggctgcgtga ttgcgtggaa cagcaaaaac     1320

ctggatagca aagtgggcgg caactataac tatcgctttc gcctgtttcg caaaagcaac     1380

ctgaaaccgt ttgaacgcga tattagcacc gaaatttatc aggcgggcaa caccccgtgc     1440

aacggcgtga aaggctttaa ctgctatttt ccgctgcaga gctatggctt tcagccgacc     1500

tatggcgtgg gctatcagcc gtatcgcgtg gtggtgctga gctttgaact gctgcatgcg     1560

ccggcgaccg tgtgcggccc gaaaaaaagc accaacctgg tgaaaaacaa atgcgtgaac     1620

tttaacttta acggcctgac cggcaccggc gtgctgaccg aaagcaacaa aaaatttctg     1680

ccgtttcagc agtttggccg cgatattgcg gataccaccg atgcggtgcg cgatccgcag     1740

accctggaaa ttctggatat taccccgtgc agctttggcg gcgtgagcgt gattaccccg     1800

ggcaccaaca ccagcaacca ggtggcggtg ctgtatcagg gcgtgaactg caccgaagtg     1860

ccggtggcga ttcatgcgga tcagctgacc ccgacctggc gcgtgtatag caccggcagc     1920

aacgtgtttc agacccgcgc gggctgcctg attggcgcgg aacatgtgaa caacagctat     1980

gaatgcgata ttccgattgg cgcgggcatt tgcgcgagct atcagacccc gaccaacagc     2040

catcgccgcg cgcgcagcgt ggcgagccag agcattattg cgtataccat gagcctgggc     2100

gtggaaaaca gcgtggcgta tagcaacaac agcattgcga ttccgaccaa ctttaccatt     2160

agcgtgacca ccgaaattct gccggtgagc atgaccaaaa ccagcgtgga ttgcaccatg     2220

tatatttgcg gcgatagcac cgaatgcagc aacctgctgc tgcagtatgg cagcttttgc     2280

acccagctga accgcgcgct gaccggcatt gcggtggaac aggataaaaa cacccaggaa     2340

gtgtttgcgc aggtgaaaca gatttataaa accccgccga ttaaagattt tggcggcttt     2400

aactttagcc agattctgcc ggatccgagc aaaccgagca aacgcagctt tattgaagat     2460

ctgctgttta acaaagtgac cctggcggat gcgggcttta ttaaacagta tggcgattgc     2520

ctgggcgata ttgcggcgcg cgatctgatt tgcgcgcaga aatttaacgg cctgaccgtg     2580

ctgccgccgc tgctgaccga tgaaatgatt gcgcagtata ccagcgcgct gctggcgggc     2640

accattacca gcggctggac ctttggcgcg ggcgcggcgc tgcagattcc gtttgcgatg     2700

cagatggcgt atcgctttaa cggcattggc gtgacccaga acgtgctgta tgaaaaccag     2760

aaactgattg cgaaccagtt taacagcgcg attggcaaaa ttcaggatag cctgagcagc     2820

accgcgagcg cgctgggcaa actgcaggat gtggtgaacc agaacgcgca ggcgctgaac     2880

accctggtga aacagctgag cagcaacttt ggcgcgatta gcagcgtgct gaacgatatt     2940

ctgagccgcc tggataaagt ggaagcggaa gtgcagattg atcgcctgat taccggccgc     3000

ctgcagagcc tgcagaccta tgtgacccag cagctgattc gcgcggcgga aattcgcgcg     3060

agcgcgaacc tggcggcgac caaaatgagc gaatgcgtgc tgggccagag caaacgcgtg     3120

gatttttgcg gcaaaggcta tcatctgatg agctttccgc agagcgcgcc gcatggcgtg     3180

gtgtttctgc atgtgaccta tgtgccggcg caggaaaaaa actttaccac cgcgccggcg     3240

atttgccatg atggcaaagc gcattttccg cgcgaaggcg tgtttgtgag caacggcacc     3300

cattggtttg tgacccagcg caacttttat gaaccgcaga ttattaccac cgataacacc     3360

tttgtgagcg gcaactgcga tgtggtgatt ggcattgtga acaacaccgt gtatgatccg     3420

ctgcagccgg aactggatag ctttaaagaa gaactggata aatattttaa aaaccatacc     3480

agcccggatg tggatctggg cgatattagc ggcattaacg cgagcgtggt gaacattcag     3540

aaagaaattg atcgcctgaa cgaagtggcg aaaaacctga acgaaagcct gattgatctg     3600

caggaactgg gcaaatatga acagtatatt aaatggccgt ggtatatttg gctgggcttt     3660

attgcgggcc tgattgcgat tgtgatggtg accattatgc tgtgctgcat gaccagctgc     3720

tgcagctgcc tgaaaggctg ctgcagctgc ggcagctgct gcaaatttga tgaagatgat     3780

agcgaaccgg tgctgaaagg cgtgaaactg cattatacc                            3819


<210> 32
<211> 3819
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<223> COVID19 variant mRNA

<400> 32
auguuugugu uucuggugcu gcugccgcug gugagcagcc agugcgugaa cuuuaccacc       60

cgcacccagc ugccgccggc guauaccaac agcuuuaccc gcggcgugua uuauccggau      120

aaaguguuuc gcagcagcgu gcugcauagc acccaggauc uguuucugcc guuuuuuagc      180

aacgugaccu gguuucaugc gauucaugug agcggcacca acggcaccaa acgcuuugau      240

aacccggugc ugccguuuaa cgauggcgug uauuuugcga gcaccgaaaa aagcaacauu      300

auucgcggcu ggauuuuugg caccacccug gauagcaaaa cccagagccu gcugauugug      360

aacaacgcga ccaacguggu gauuaaagug ugcgaauuuc aguuuugcaa cgauccguuu      420

cugggcgugu auuaucauaa aaacaacaaa agcuggaugg aaagcgaauu ucgcguguau      480

agcagcgcga acaacugcac cuuugaauau gugagccagc cguuucugau ggaucuggaa      540

ggcaaacagg gcaacuuuaa aaaccugcgc gaauuugugu uuaaaaacau ugauggcuau      600

uuuaaaauuu auagcaaaca uaccccgauu aaccuggugc gcgaucugcc gcagggcuuu      660

agcgcgcugg aaccgcuggu ggaucugccg auuggcauua acauuacccg cuuucagacc      720

cugcuggcgc ugcauauuag cuaucugacc ccgggcggca gcagcagcgg cuggaccgcg      780

ggcgcggcgg cguauuaugu gggcuaucug cagccgcgca ccuuucugcu gaaauauaac      840

gaaaacggca ccauuaccga ugcgguggau ugcgcgcugg auccgcugag cgaaaccaaa      900

ugcacccuga aaagcuuuac cguggaaaaa ggcauuuauc agaccagcaa cuuucgcgug      960

cagccgaccg aaagcauugu gcgcuuuccg aacauuacca accugugccc guuuggcgaa     1020

guguuuaacg cgacccgcuu ugcgagcgug uaugcgugga accgcaaacg cauuagcaac     1080

ugcguggcgg auuauagcgu gcuguauaac agcgcgagcu uuagcaccuu uaaaugcuau     1140

ggcgugagcc cgaccaaacu gaacgaucug ugcuuuacca acguguaugc ggauagcuuu     1200

gugauucgcg gcgaugaagu gcgccagauu gcgccgggcc agaccggcaa cauugcggau     1260

uauaacuaua aacugccgga ugauuuuacc ggcugcguga uugcguggaa cagcaaaaac     1320

cuggauagca aagugggcgg caacuauaac uaucgcuuuc gccuguuucg caaaagcaac     1380

cugaaaccgu uugaacgcga uauuagcacc gaaauuuauc aggcgggcaa caccccgugc     1440

aacggcguga aaggcuuuaa cugcuauuuu ccgcugcaga gcuauggcuu ucagccgacc     1500

uauggcgugg gcuaucagcc guaucgcgug guggugcuga gcuuugaacu gcugcaugcg     1560

ccggcgaccg ugugcggccc gaaaaaaagc accaaccugg ugaaaaacaa augcgugaac     1620

uuuaacuuua acggccugac cggcaccggc gugcugaccg aaagcaacaa aaaauuucug     1680

ccguuucagc aguuuggccg cgauauugcg gauaccaccg augcggugcg cgauccgcag     1740

acccuggaaa uucuggauau uaccccgugc agcuuuggcg gcgugagcgu gauuaccccg     1800

ggcaccaaca ccagcaacca gguggcggug cuguaucagg gcgugaacug caccgaagug     1860

ccgguggcga uucaugcgga ucagcugacc ccgaccuggc gcguguauag caccggcagc     1920

aacguguuuc agacccgcgc gggcugccug auuggcgcgg aacaugugaa caacagcuau     1980

gaaugcgaua uuccgauugg cgcgggcauu ugcgcgagcu aucagacccc gaccaacagc     2040

caucgccgcg cgcgcagcgu ggcgagccag agcauuauug cguauaccau gagccugggc     2100

guggaaaaca gcguggcgua uagcaacaac agcauugcga uuccgaccaa cuuuaccauu     2160

agcgugacca ccgaaauucu gccggugagc augaccaaaa ccagcgugga uugcaccaug     2220

uauauuugcg gcgauagcac cgaaugcagc aaccugcugc ugcaguaugg cagcuuuugc     2280

acccagcuga accgcgcgcu gaccggcauu gcgguggaac aggauaaaaa cacccaggaa     2340

guguuugcgc aggugaaaca gauuuauaaa accccgccga uuaaagauuu uggcggcuuu     2400

aacuuuagcc agauucugcc ggauccgagc aaaccgagca aacgcagcuu uauugaagau     2460

cugcuguuua acaaagugac ccuggcggau gcgggcuuua uuaaacagua uggcgauugc     2520

cugggcgaua uugcggcgcg cgaucugauu ugcgcgcaga aauuuaacgg ccugaccgug     2580

cugccgccgc ugcugaccga ugaaaugauu gcgcaguaua ccagcgcgcu gcuggcgggc     2640

accauuacca gcggcuggac cuuuggcgcg ggcgcggcgc ugcagauucc guuugcgaug     2700

cagauggcgu aucgcuuuaa cggcauuggc gugacccaga acgugcugua ugaaaaccag     2760

aaacugauug cgaaccaguu uaacagcgcg auuggcaaaa uucaggauag ccugagcagc     2820

accgcgagcg cgcugggcaa acugcaggau guggugaacc agaacgcgca ggcgcugaac     2880

acccugguga aacagcugag cagcaacuuu ggcgcgauua gcagcgugcu gaacgauauu     2940

cugagccgcc uggauaaagu ggaagcggaa gugcagauug aucgccugau uaccggccgc     3000

cugcagagcc ugcagaccua ugugacccag cagcugauuc gcgcggcgga aauucgcgcg     3060

agcgcgaacc uggcggcgac caaaaugagc gaaugcgugc ugggccagag caaacgcgug     3120

gauuuuugcg gcaaaggcua ucaucugaug agcuuuccgc agagcgcgcc gcauggcgug     3180

guguuucugc augugaccua ugugccggcg caggaaaaaa acuuuaccac cgcgccggcg     3240

auuugccaug auggcaaagc gcauuuuccg cgcgaaggcg uguuugugag caacggcacc     3300

cauugguuug ugacccagcg caacuuuuau gaaccgcaga uuauuaccac cgauaacacc     3360

uuugugagcg gcaacugcga uguggugauu ggcauuguga acaacaccgu guaugauccg     3420

cugcagccgg aacuggauag cuuuaaagaa gaacuggaua aauauuuuaa aaaccauacc     3480

agcccggaug uggaucuggg cgauauuagc ggcauuaacg cgagcguggu gaacauucag     3540

aaagaaauug aucgccugaa cgaaguggcg aaaaaccuga acgaaagccu gauugaucug     3600

caggaacugg gcaaauauga acaguauauu aaauggccgu gguauauuug gcugggcuuu     3660

auugcgggcc ugauugcgau ugugauggug accauuaugc ugugcugcau gaccagcugc     3720

ugcagcugcc ugaaaggcug cugcagcugc ggcagcugcu gcaaauuuga ugaagaugau     3780

agcgaaccgg ugcugaaagg cgugaaacug cauuauacc                            3819


<210> 33
<211> 731
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<223> S2 (Subunit 2 of Spike protein and S1/S2 cleavage region)

<400> 33
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
1               5                   10                  15      


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
            20                  25                  30          


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
        35                  40                  45              


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
    50                  55                  60                  


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
65                  70                  75                  80  


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
                85                  90                  95      


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
            100                 105                 110         


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
        115                 120                 125             


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
    130                 135                 140                 


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
145                 150                 155                 160 


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
                165                 170                 175     


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
            180                 185                 190         


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
        195                 200                 205             


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
    210                 215                 220                 


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
225                 230                 235                 240 


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
                245                 250                 255     


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
            260                 265                 270         


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
        275                 280                 285             


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
    290                 295                 300                 


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
305                 310                 315                 320 


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
                325                 330                 335     


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
            340                 345                 350         


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
        355                 360                 365             


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
    370                 375                 380                 


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
385                 390                 395                 400 


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
                405                 410                 415     


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
            420                 425                 430         


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
        435                 440                 445             


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
    450                 455                 460                 


Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala 
465                 470                 475                 480 


Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 
                485                 490                 495     


Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln 
            500                 505                 510         


Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala 
        515                 520                 525             


Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys 
    530                 535                 540                 


Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp 
545                 550                 555                 560 


Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp 
                565                 570                 575     


Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn 
            580                 585                 590         


Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu 
        595                 600                 605             


Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu 
    610                 615                 620                 


Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu 
625                 630                 635                 640 


Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile 
                645                 650                 655     


Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp 
            660                 665                 670         


Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val 
        675                 680                 685             


Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly 
    690                 695                 700                 


Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu 
705                 710                 715                 720 


Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr 
                725                 730     


<210> 34
<211> 6927
<212> DNA
<213> Homo sapiens

<400> 34
acctcagcgg gaagcggaga cgcaagcagc tggatctccg gtaactgaga catagggtat       60

aactgttgtc gcggcggagg aagtgaggac ggcgccaagg gccttccggg ccagtgttgg      120

atccctgtag tttgtgaaga tggtgttgct aacaatgatc gcccgagtgg cggacgggct      180

cccgctggcc gcctcgatgc aggaggacga acagtctggc cgggaccttc aacaatatca      240

gagtcaggct aagcaactct ttcgaaagtt gaatgaacag tcccctacca gatgtacctt      300

ggaagcagga gccatgactt ttcactacat tattgagcag ggggtgtgtt atttggtttt      360

atgtgaagct gccttcccta agaagttggc ttttgcctac ctagaagatt tgcactcaga      420

atttgatgaa cagcatggaa agaaggtgcc cactgtgtcc cgaccctatt cctttattga      480

atttgatact ttcattcaga aaaccaagaa gctctacatt gacagtcgtg ctcgaagaaa      540

tctaggctcc atcaacactg aattgcaaga tgtgcagagg atcatggtgg ccaatattga      600

agaagtgtta caacgaggag aagcactctc agcattggat tcaaaggcta acaatttgtc      660

cagtctgtcc aagaaatacc gccaggatgc gaagtacttg aacatgcgtt ccacttatgc      720

caaacttgca gcagtagctg tatttttcat catgttaata gtgtatgtcc gattctggtg      780

gctgtgaaat aatgaataca gtcactggta agggagaacc tagaacccag taggtgtata      840

ttttcaggaa actgagctca cagagatgtg tattagaatc caagtggaac ttctgcctct      900

aaagaccttg caagaaaaga gatgccctga aaatgaaagg ttgcacctca tttaatgaag      960

cttaacccta tgtagaaagt ctctttcggg ggcagaggct ttctctgggt gccaagccat     1020

atatattagg gaatagtaga ttgttaattt cgttttttcc ctcccagtgc attttaaaaa     1080

cagcactggc tggggcattc tcattctctg atggagccat caatgagatt taacttagtc     1140

aacctgtgct agcaacattc tgaaattcct tcaaagaagg cagtcctttg ggaaggtgtt     1200

tttttttttt tttttttttt tgactctaat caacattcct tttgttggtg acatttgtga     1260

ttttcagtaa tctgagtttt tgatggcctt ttaaacaaga ctccagtatg tgaaggttaa     1320

ttgctgtgct ccacagatct tgtctattgg cccctgtaga aagttaacct ttgttgtttt     1380

ccttttataa tttgcttatt gcacaattgc tttagggtaa gtgaattata ttaagatgcc     1440

ttgaaattat agcactcctt gattaagaag ctaaaatgtt tctctcattt actccttaaa     1500

caaaagactt aaattagttt gggtcattat tacttttatt ttgcagcatt tggtttgtta     1560

ttagcgtaag agcaagtata ggatatggag aggcccctgg cttcatgaga acaaaggcag     1620

gcccaggtta taattacagc tttctcctgc cccttcttta ctttctctac cacagttttc     1680

tccactgttt gttttcctct tgccacaatt tgctaacatt taaaaaattt tcctgcaccc     1740

agtagtttca tatcctgtag acatcctctt aggacattct caaatttcaa aataaaaaat     1800

attcatctat gtagttaatt aaagttaaag tttttgcaga tcaactactc aaactactaa     1860

atacatttac ctgagaaaaa gtctctgaga gcacttcatt cctgttttag ttcgtgtaaa     1920

ttctctgaga atgttctgga gatagataac tcatttacag tggtttctat taactaatta     1980

aagtacccat gattttttcc ttttctgctc agggatgatg gagatttcct tttaccttct     2040

gaggtagaat tttttaatgg ggaaaatagg ccttttaaat attattgcca gggtctgcaa     2100

tataacttaa aattcctgta catactgcaa atatttcttt aaattgcaca ggaaaatgag     2160

cgaacttttt atttcttaat atctttggca aaaaacttta accagtaagc aattttataa     2220

ccctgaggga tcatcaaaga tactatcctg attcctggta aggaaaaata tattatttcc     2280

ttataacaag gcaaggagaa atgctatttt attcctgata atttatataa ctagaataat     2340

ttttttcctt tcttttatgg acctaaatct gccaattggg aattttgtgc atgaaatatg     2400

aagttacttt ttatagataa tcagtgcttt taagtcccta aaaggctcct gctgaagtaa     2460

tgatgatgtt aataataaaa gcctttgaaa ggctgaaaac ctacatagtg gtaccatagt     2520

atttggagct tctataggag tggagagggg cagctcattg ttgagagttg catgctgcaa     2580

cctaatggtc agcaatgaaa taaatacttg tagaatgttc acttcagtgt gaagttttgt     2640

tatctagtta atttatatac atatatcctt tgtagataca tttctatcta atcttgttgg     2700

gctaattaag aaataagggg tggggtaatt gtcaacaaag ggagaagaaa gtggtttaag     2760

atcagggcag cagaaaaatt agagaacaag aatatcataa tatggctcct ggttttcttt     2820

ataagaggca gtgggaagat ctgactagat gaaatgtatc atcaaccaaa ctggcatcta     2880

aaatagaatg ggataaatac tgtatggggt tattggaggc atattaagaa aggacaccta     2940

atttattttg ggaagaagta tgttaagaga agactttcta gagaaggaga atggggcatt     3000

ctaggaagag tcaatggcat gtgcaaaggc atgaataaag acagtgaggc atattttgga     3060

aatgtaacag cttgattcag cttagcccat agggtaagca tagacaacag aggagacttg     3120

aggaatgaga actagatggg tacactatca taaagggact tgtctatcat gctgaggagt     3180

ttagaccatc ttaatggtag tggccaagga tggcatcaga tttatagttt caagtgatca     3240

taatattggc ataaaagata tattagggag gaagcctgaa gtagggagat gaaaataagg     3300

agccatcaaa ggcagaatga aacttaggca gatttcaagt gattttcaaa aatgttgtga     3360

tcagaggtac cagataataa ctattacata acactttctt tgttaggagc ttatttctca     3420

cactgaccaa agcttttgaa gtaagtactc tttacaccac tatataaata aaccttacaa     3480

aggattctgc tttgaggcat gagagagtta agtcatttgc ccaaagtcac agagttagaa     3540

agtaatagag ctaagatttg aacctaggca gtttggctcc agagtctgtg ctcttacgct     3600

atattaccac caagaggtca aataaatacc aaagaatgta ttttcgaatt taacaatgag     3660

gaacttaatc atacaggcag aagtaattcc agagcactgg agacagaagc cagattgcca     3720

tatgggttaa agagtgtgta aaccactagg aagtaaagac atagaactac tctcacaagt     3780

gcttttctgg ttattgtgac gctgaacttc atggcttgtt ttaattaaga catcttacaa     3840

gtgtcaaaat ttggaaatat ttggacactg tacactctgg ttatttaaat atctaacaat     3900

ggttcttgag cattttgaga aacctttgaa aatctgatga aaggtatgtg ccattactct     3960

agaaaaatgt tcctgtgtac atgcacatca agtatcacat actgtttcag gctgttcaaa     4020

gactacaaag tctgttcatg acctaatggt ccatgttccc tcagttaaga gctccagaga     4080

taaaggatgt ggaactcaaa ggtaagtacc cagagccttg aaaactccat ctgtgacttg     4140

gaagaattct acaatttgaa ttaactttgt ggagagagat atatttttga aaaattgtgt     4200

gtaccaaaaa aatttcatat caaataatat tttcctgtag tgcattcaag gatctggttc     4260

cacagcaaaa aattgttttg gtctcagttc ctcaaaatca catttaagga gcttgagatt     4320

tatattttct acttaataag tcttacaaaa gcaagttaag aaggaaaatg gacaatcatt     4380

tctgcacata tagggtttaa taaaacatgt ataataaaat atctcatatt ttaaatttcc     4440

accttattgg tagctttcat gacaaagggc tagggtgctg atggccatac aattaaggtt     4500

tttggttagt tagttagcag aactaactga ctcctacctg gtgggttttt cttttgtttg     4560

gttggttggt tggttggttt tttcccagat ggctcaggag gaaggtaaat agcagtcatt     4620

gtatgtgtga cagagtttga gatagaatga gcatattgaa tctcacatcc tattcttatt     4680

actgtcaggc agcgttgacc tagcagtata aaactatctg aagcaatgta gtcactcagt     4740

tctcataaag tttatttcaa gtactgtaac aattcatgtt tggattagaa aagtcactag     4800

aaatttgact tccatatagt aatctatact tttttctctc atttccttca ttttttgagc     4860

cgtaagtgta aggcattttg ctggtattat tacaatggtt atgaggagtt tctttgcttg     4920

cccaaggtca catagctagc aagttaaagt agattcaaat ccaggcctgc tagataccaa     4980

attattattt aagagtactt ttcactactc ctaaataatg acacagatac gtttgtctta     5040

cacatttcac tttattgtca agttattagt atgtttattt tcaaaagtta ttttttgcaa     5100

tttcttttta ttattccgta ctttttaaat ttacttcatt atcacgtctt cctttattct     5160

ttttaaatag tttttgcttt tgttattttg ttttcccttt tttactcttg gtttgtaata     5220

cctctttcct tatttgctcc tttctcattt gatctcaatg ttaatccaac tgttttccac     5280

atctgattca ctaaaatttt agcccttaaa aaaaaaattc ctgtttttcc tatctccttt     5340

tgtccattct cttctccttg cctcacttct tttatctttt tccattttac tttcattttt     5400

tgtttctcta gatgttgttt tgacatatga gttaatgtac tggtacaatt ttgcatctgt     5460

aaattagagc ttcagaatca actgagtgta tttattcttt atttttaggc ctaaatttat     5520

cttacctttt attgatttta taatatacta tactctttca ttttagtctg catatgttag     5580

ccaaagaaga tatgcccctg ttttaagaaa tctctgtaaa aaatgtcaag tgtgacaaga     5640

attcttcaag aaacaagctc ctctagtttg tcttctatat ttagagcttc aacagttacc     5700

tatattactg gtaactccca aatatacctt caaacttgtt ttttgggccc aagttttttg     5760

cttcatatat atctgttttg aatatcccat aaataattgc atctaaagca tacctccact     5820

ccattgttct caaagataaa accaaacctg tgctgcttct tatatttcta gtatttaagc     5880

gtcacctgcc acccctttac ctgagctaca agtcacgcat tgcattagac tcctctgctt     5940

tcttctttca cctctaacta gactattaac caaaaatttt ttaatataac tttcaaaagg     6000

tattttatta catcatttcc atcctttatg tttgggttca agccctcatt aactttaaca     6060

tggattcttg gagtaccctc cttactgatt ttgttacaca tgtccctctt ttagtcagta     6120

ctaccatgat aataccatgg ataataattt tttcattttt atttttagtc ttgctctgtc     6180

gccgaggcta gagtgcagtg gcgcgatctc agctcactgc aacctccacc tcccgggttc     6240

aagtgattct cctgcctcag cctactgagt agctgggatt acaggcacct gccacagctc     6300

ctggctaatt tttgtatttt tagtagagat ggagtttcac cgtcttgaac tcctgacctc     6360

atgatccacc ctcctcggcc tcccaaagtg ctgggattac aggcatgggc cactgcgccc     6420

ggccaataat ttttgtgtgt gtgtgtgcta atcatactac attttcttta gaataaaaga     6480

tcacatactt gtttgccatt cgcagtctgg ccccattgtg ccattctaga cttacctcct     6540

gccactcccc accagctttg ttttgtctta gccacacaaa ataatctagc gtctctaacc     6600

agtcaaacat tttaccttgt gccttggctc actctgtgcc ttttctccag aatatctttc     6660

tgtgtacttt tctcccatcc ttttaccttt aaacctgctg ctatggtttg catgttgttt     6720

ggcccctcca aaactcatgt tgtagttcaa ttgccaatgt aatagtgttg ggagatggta     6780

cttttaagag gtaattaggt tgctaagatg gattaacatc tttctcttga cactgagact     6840

gggttctcct gggaatggtt agttcccaag agagtgagtt gttataaaac aatgctgcct     6900

cttctatttt gcgctttttg tttgcac                                         6927


