                         SEQUENCE LISTING

<110>  InflaRx GmbH
 
<120>  Inhibitors of C5a for the Treatment of Corona Virus Infection

<130>  680-23 PCT

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Cys Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser His Lys Asp Met Gln Leu Gly Arg 
65                  70                  


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Asp Glu Thr Cys Glu Gln Arg Ala 
1               5                   


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser His Lys Asp Met Gln Leu 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Glu Thr Cys Glu Gln Arg 
1               5           


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

His Lys Asp Met Gln 
1               5   


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 CDR3 heavy chain

<400>  6

Cys Ala Arg Gly Asn Asp Gly Tyr Tyr Gly Phe Ala Tyr 
1               5                   10              


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 CDR3 heavy chain

<400>  7

Cys Thr Arg Arg Gly Leu Tyr Asp Gly Ser Ser Tyr Phe Ala Tyr 
1               5                   10                  15  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 CDR3 light chain

<400>  8

Cys Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 CDR3 light chain

<400>  9

Cys Gln Gln Asn Asn Glu Asp Pro Leu Thr 
1               5                   10  


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 CDR2 heavy chain

<400>  10

Ile Asp Pro Ser Asp Ser Glu Ser Arg Leu Asp Gln 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 CDR2 heavy chain

<400>  11

Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu 
1               5                   10          


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 CDR2 light chain

<400>  12

Ile Tyr Ala Ala Ser Asn Leu 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 CDR2 light chain

<400>  13

Ile Tyr Ala Ala Ser Asn Leu 
1               5           


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 CDR1 heavy chain

<400>  14

Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Phe Trp Met Asp 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 CDR1 heavy chain

<400>  15

Cys Lys Ala Thr Gly Asn Thr Phe Ser Gly Tyr Trp Ile Glu 
1               5                   10                  


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 CDR1 light chain

<400>  16

Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Lys 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 CDR1 light chain

<400>  17

Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR1 heavy chain

<400>  18

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser 
            20      


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR2 heavy chain

<400>  19

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg 
1               5                   10                  15  


<210>  20
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR3 heavy chain

<400>  20

Arg Phe Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
1               5                   10                  15      


Val Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr 
            20                  25                  30          


Tyr 
    


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR4 heavy chain

<400>  21

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR1 light chain

<400>  22

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser 
            20          


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR2 light chain

<400>  23

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
1               5                   10              


<210>  24
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR3 light chain

<400>  24

Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
1               5                   10                  15      


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr 
            20                  25                  30          


Tyr 
    


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IFX-1 FR4 light chain

<400>  25

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR1 heavy chain

<400>  26

Val Gln Leu Leu Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser 
            20  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR2 heavy chain

<400>  27

Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
1               5                   10                  15  


<210>  28
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR3 heavy chain

<400>  28

Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr 
1               5                   10                  15      


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            20                  25                  30          


Tyr 
    


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR4 heavy chain

<400>  29

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  30
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR1 light chain

<400>  30

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser 
            20          


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR2 light chain

<400>  31

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
1               5                   10              


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR3 light chain

<400>  32

Gly Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
1               5                   10                  15      


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Val Ala Ala Thr Tyr 
            20                  25                  30          


Tyr 
    


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INab708 FR4 light chain

<400>  33

Phe Gly Ala Gly Thr Leu Leu Glu Leu Lys 
1               5                   10  


<210>  34
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Phe 
            20                  25                  30          


Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ser Asp Ser Glu Ser Arg Leu Asp Gln Arg Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Asp Gly Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  35
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  35

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Lys Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  36
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  36

Val Gln Leu Leu Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Thr Gly Asn Thr Phe Ser Gly Tyr Trp 
            20                  25                  30          


Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Arg Gly Leu Tyr Asp Gly Ser Ser Tyr Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  37
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  37

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Val Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Leu Leu Glu Leu Lys 
            100                 105                 110     


