                         SEQUENCE LISTING

<110>  Biosion Inc.
 
<120>  ANTIBODIES BINDING SIGLEC15 AND USES THEREOF

<130>  55532 00027

<150>  63/000,566
<151>  2020-03-27

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  1

Thr Tyr Trp Ile Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Asp or Glu

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be Gln or Lys

<400>  2

Leu Ile Asp Pro Ser Xaa Ser Tyr Thr Asn Tyr Ser Pro Ser Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  3

Gly Gly Tyr Tyr Gly Ser Glu Glu Asp Tyr 
1               5                   10  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Ser Arg Leu Ala 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  5

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  6

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3


<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be Asp or Glu

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be Gln or Lys

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asp Pro Ser Xaa Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Xaa Gly His Val Thr Ile Ser Thr Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Ser Glu Glu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Arg Leu Ala Trp Phe Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Phe Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Phe Lys 
            100                 105             


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for A1E10G7H9

<400>  9

Ser Ser Asn Trp Trp His 
1               5       


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for A1E10G7H9

<400>  10

Glu Ile Tyr His Ser Gly Asn Thr Asn Tyr Lys Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for A1E10G7H9

<400>  11

Asp Glu Gly Asn Gly Trp Ser Asn Ala Phe Asp Ile 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for A1E10G7H9

<400>  12

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for A1E10G7H9

<400>  13

Gly Ala Ser Gly Gly Ala Thr 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for A1E10G7H9

<400>  14

Gln Gln Tyr Gly Ser Ser Pro Ile Thr 
1               5                   


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for A1E10G7H9

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Asn Thr Asn Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Gly Asn Gly Trp Ser Asn Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for A1E10G7H9

<400>  16

Glu Asn Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Phe Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Gly Gly Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  17
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant region

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain constant region

<400>  18

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  19
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Siglec15-Fc

<400>  19

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr Glu Asn Leu Tyr Phe Gln Gly Glu Pro 
            260                 265                 270         


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly Lys 
            500         


<210>  20
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Siglec15-his

<400>  20

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr His His His His His His His His 
            260                 265                 270     


<210>  21
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus Siglec15-his

<400>  21

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Ala Glu Val Ser Ala Ala Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Ile Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Gly Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Gly Ser 
        195                 200                 205             


Ala Ala Val Pro Ser Ser Gly Gln Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Asn His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr His His His His His His His His 
            260                 265                 270     


<210>  22
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Siglec15-his

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Arg Arg Asp Ala Ser Gly Asp Leu Leu Asn Thr Glu Ala 
            20                  25                  30          


His Ser Ala Pro Ala Gln Arg Trp Ser Met Gln Val Pro Ala Glu Val 
        35                  40                  45              


Asn Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys Thr Phe Thr His 
    50                  55                  60                  


Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile Trp Arg Ser Gly 
65                  70                  75                  80  


Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Thr Ala Ala Pro Gly 
                85                  90                  95      


Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly Arg Phe Arg Leu 
            100                 105                 110         


Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg Val Glu Arg Leu 
        115                 120                 125             


Ala Leu Ala Asp Ser Gly Arg Tyr Phe Cys Arg Val Glu Phe Thr Gly 
    130                 135                 140                 


Asp Ala His Asp Arg Tyr Glu Ser Arg His Gly Val Arg Leu Arg Val 
145                 150                 155                 160 


Thr Ala Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu Pro Gly Pro 
                165                 170                 175     


Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu Pro Pro Pro 
            180                 185                 190         


Ala Leu Ala Trp Ser Gly Pro Ala Pro Gly Asn Ser Ser Ala Ala Leu 
        195                 200                 205             


Gln Gly Gln Gly His Gly Tyr Gln Val Thr Ala Glu Leu Pro Ala Leu 
    210                 215                 220                 


Thr Arg Asp Gly Arg Tyr Thr Cys Thr Ala Ala Asn Ser Leu Gly Arg 
225                 230                 235                 240 


Ala Glu Ala Ser Val Tyr Leu Phe Arg Phe His Gly Ala Pro Gly Thr 
                245                 250                 255     


Ser Thr His His His His His His His His 
            260                 265     


<210>  23
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LRRC4C-Fc

<400>  23

Met Leu Asn Lys Met Thr Leu His Pro Gln Gln Ile Met Ile Gly Pro 
1               5                   10                  15      


Arg Phe Asn Arg Ala Leu Phe Asp Pro Leu Leu Val Val Leu Leu Ala 
            20                  25                  30          


Leu Gln Leu Leu Val Val Ala Gly Leu Val Arg Ala Gln Thr Cys Pro 
        35                  40                  45              


Ser Val Cys Ser Cys Ser Asn Gln Phe Ser Lys Val Ile Cys Val Arg 
    50                  55                  60                  


Lys Asn Leu Arg Glu Val Pro Asp Gly Ile Ser Thr Asn Thr Arg Leu 
65                  70                  75                  80  


Leu Asn Leu His Glu Asn Gln Ile Gln Ile Ile Lys Val Asn Ser Phe 
                85                  90                  95      


Lys His Leu Arg His Leu Glu Ile Leu Gln Leu Ser Arg Asn His Ile 
            100                 105                 110         


Arg Thr Ile Glu Ile Gly Ala Phe Asn Gly Leu Ala Asn Leu Asn Thr 
        115                 120                 125             


Leu Glu Leu Phe Asp Asn Arg Leu Thr Thr Ile Pro Asn Gly Ala Phe 
    130                 135                 140                 


Val Tyr Leu Ser Lys Leu Lys Glu Leu Trp Leu Arg Asn Asn Pro Ile 
145                 150                 155                 160 


Glu Ser Ile Pro Ser Tyr Ala Phe Asn Arg Ile Pro Ser Leu Arg Arg 
                165                 170                 175     


Leu Asp Leu Gly Glu Leu Lys Arg Leu Ser Tyr Ile Ser Glu Gly Ala 
            180                 185                 190         


Phe Glu Gly Leu Ser Asn Leu Arg Tyr Leu Asn Leu Ala Met Cys Asn 
        195                 200                 205             


Leu Arg Glu Ile Pro Asn Leu Thr Pro Leu Ile Lys Leu Asp Glu Leu 
    210                 215                 220                 


Asp Leu Ser Gly Asn His Leu Ser Ala Ile Arg Pro Gly Ser Phe Gln 
225                 230                 235                 240 


Gly Leu Met His Leu Gln Lys Leu Trp Met Ile Gln Ser Gln Ile Gln 
                245                 250                 255     


Val Ile Glu Arg Asn Ala Phe Asp Asn Leu Gln Ser Leu Val Glu Ile 
            260                 265                 270         


Asn Leu Ala His Asn Asn Leu Thr Leu Leu Pro His Asp Leu Phe Thr 
        275                 280                 285             


Pro Leu His His Leu Glu Arg Ile His Leu His His Asn Pro Trp Asn 
    290                 295                 300                 


Cys Asn Cys Asp Ile Leu Trp Leu Ser Trp Trp Ile Lys Asp Met Ala 
305                 310                 315                 320 


Pro Ser Asn Thr Ala Cys Cys Ala Arg Cys Asn Thr Pro Pro Asn Leu 
                325                 330                 335     


Lys Gly Arg Tyr Ile Gly Glu Leu Asp Gln Asn Tyr Phe Thr Cys Tyr 
            340                 345                 350         


Ala Pro Val Ile Val Glu Pro Pro Ala Asp Leu Asn Val Thr Glu Gly 
        355                 360                 365             


Met Ala Ala Glu Leu Lys Cys Arg Ala Ser Thr Ser Leu Thr Ser Val 
    370                 375                 380                 


Ser Trp Ile Thr Pro Asn Gly Thr Val Met Thr His Gly Ala Tyr Lys 
385                 390                 395                 400 


Val Arg Ile Ala Val Leu Ser Asp Gly Thr Leu Asn Phe Thr Asn Val 
                405                 410                 415     


Thr Val Gln Asp Thr Gly Met Tyr Thr Cys Met Val Ser Asn Ser Val 
            420                 425                 430         


Gly Asn Thr Thr Ala Ser Ala Thr Leu Asn Val Thr Ala Ala Thr Thr 
        435                 440                 445             


Thr Pro Phe Ser Tyr Phe Ser Thr Val Thr Val Glu Thr Met Glu Pro 
    450                 455                 460                 


Ser Gln Asp Glu Ala Arg Thr Thr Asp Asn Asn Val Gly Pro Thr Pro 
465                 470                 475                 480 


Val Val Asp Trp Glu Thr Thr Asn Val Thr Thr Ser Leu Thr Pro Gln 
                485                 490                 495     


Ser Thr Arg Ser Thr Glu Lys Thr Phe Thr Ile Pro Val Thr Asp Ile 
            500                 505                 510         


Asn Ser Gly Ile Pro Gly Ile Asp Glu Val Met Lys Thr Thr Lys Glu 
        515                 520                 525             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    530                 535                 540                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
545                 550                 555                 560 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                565                 570                 575     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            580                 585                 590         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        595                 600                 605             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    610                 615                 620                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
625                 630                 635                 640 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                645                 650                 655     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            660                 665                 670         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        675                 680                 685             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    690                 695                 700                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
705                 710                 715                 720 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                725                 730                 735     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            740                 745                 750         


Leu Ser Leu Ser Pro Gly Lys 
        755                 


<210>  24
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Siglec15-ch5G9

<400>  24

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Cys Gly Ser Asp Thr Met His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  25
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of Siglec15-ch5G9

<400>  25

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Siglec15-mouse Fc

<400>  26

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu 
            20                  25                  30          


Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val 
        35                  40                  45              


Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys 
    50                  55                  60                  


Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile 
65                  70                  75                  80  


Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala 
                85                  90                  95      


Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly 
            100                 105                 110         


Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg 
        115                 120                 125             


Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val 
    130                 135                 140                 


Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val 
145                 150                 155                 160 


Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu 
                165                 170                 175     


Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu 
            180                 185                 190         


Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu 
        195                 200                 205             


Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala 
    210                 215                 220                 


Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala 
225                 230                 235                 240 


Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His 
                245                 250                 255     


Gly Ala Ser Gly Ala Ser Thr Glu Asn Leu Tyr Phe Gln Gly Glu Pro 
            260                 265                 270         


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
        275                 280                 285             


Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
    290                 295                 300                 


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
                325                 330                 335     


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
            340                 345                 350         


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
        355                 360                 365             


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
385                 390                 395                 400 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
                405                 410                 415     


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
            420                 425                 430         


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
        435                 440                 445             


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
    450                 455                 460                 


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
465                 470                 475                 480 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
                485                 490                 495     


Phe Ser Arg Thr Pro Gly Lys 
            500             


<210>  27
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for A2A5C7E8

<400>  27
gaagtgcagc tggtgcagtc cggagcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggata cagctttacc acctactgga tcagctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatgggtttg attgatccta gtgactctta taccaactac      180

agtccgtcct tccaaggcca cgtcaccatc tcaactgaca agtccatcag cactgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagagggggt      300

tactatggtt cggaagagga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  28
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for A2A5C7E8, A2A5C7E8-2 and A2A5C7E8-3

<400>  28
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagccggt tagcctggtt ccagcagaaa      120

tctggccagg ctcccagact cctcatcttt gatgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcg gacgttcggc      300

caagggacca aggtggaatt caaa                                             324


<210>  29
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for A1E10G7H9

<400>  29
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtagtaact ggtggcattg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggaa caccaactac      180

aaaccgtccc tcaagagtcg agtcaccata tcagtggaca agtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggccgtct attattgtgc gagagacgag      300

ggcaatggct ggtccaatgc ttttgatatc tggggccaag ggacaatggt caccgtctct      360

tca                                                                    363


<210>  30
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for A1E10G7H9

<400>  30
gaaaatgtgt tgacgcagtc tccaggcacc ctgtctctgt ctccagggga aagagtcacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta tcagcagaaa      120

cctggccagg ctcccaggtt cctcatctat ggtgcatccg gcggggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  31
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain constant region

<400>  31
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  32
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain constant region

<400>  32
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 for mouse B2D7H7A3C1, B2G12H3E8 and B2H2H1A7

<400>  33

Asn Tyr Trp Ile Gly 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 for mouse B2D7H7A3C1, B2G12H3E8 and B2H2H1H7

<400>  34

Asp Ile His Pro Gly Ile Asn Tyr Thr Asn Asn Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 for mouse B2D7H7A3C1, B2G12H3E8 and B2H2H1H7

<400>  35

Val Asp Tyr Asp Tyr Asp Gly Ser Tyr Ile Met Asp Tyr 
1               5                   10              


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 for mouse B2D7H7A3C1, B2G12H3E8 and B2H2H1H7

<400>  36

Arg Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 for mouse B2D7H7A3C1, B2G12H3E8 and B2H2H1H7

<400>  37

Ala Thr Ser Asn Leu Thr Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 for mouse B2D7H7A3C1, B2G12H3E8 and B2H2H1H7

<400>  38

Gln Gln Trp Asn Ser Lys Pro Trp Thr 
1               5                   


<210>  39
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse B2D7H7A3C1

<400>  39

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Gln Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ile Asn Tyr Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Gly Leu Thr Ser Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Tyr Asp Tyr Asp Gly Ser Tyr Ile Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse B2G12H3E8

<400>  40

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Gln Met Ser Cys Lys Ala Val Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ile Asn Tyr Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Gly Leu Thr Ser Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Tyr Asp Tyr Asp Gly Ser Tyr Ile Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  41
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse B2H2H1H7

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Gln Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ile Asn Tyr Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Gly Leu Thr Ser Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Tyr Asp Tyr Asp Gly Ser Tyr Ile Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse B2D7H7A3C1 and B2G12H3E8

<400>  42

Gln Ile Val Leu Ser Gln Ser Pro Ala Leu Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Thr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Asn Ser Lys Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Ser Lys Leu Glu Ile Arg 
            100                 105     


<210>  43
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse B2H2H1H7

<400>  43

Gln Ile Ile Leu Ser Gln Ser Pro Ala Leu Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Thr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Phe Cys Gln Gln Trp Asn Ser Lys Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Ser Arg Leu Glu Ile Arg 
            100                 105     


