                         SEQUENCE LISTING

<110>  ϺȲƼ޹˾
 
<120>  бĵǶϿԭ弰;

<130>  AJ7552PCT2103

<150>  CN 202010220842.3
<151>  2020-03-25

<160>  138   

<170>  PatentIn version 3.3

<210>  1
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvеɱ

<400>  1

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  2
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvеɱ

<400>  2

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  245
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFv

<400>  3

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  4
<211>  245
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvԴ

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Phe 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  5
<211>  735
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvԴ

<400>  5
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatcat acatcaagat tacactcagg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggaccaagg tggagatcaa aggctccacc tctggatccg gcaagcccgg atctggcgag    360

ggatccacca agggcgaggt gcagctggtg gagtctgggg gaggcttggt ccagcctggg    420

gggtccctga gactctcctg tgcagcctct ggggtctcat tacccgacta tggtgtaagc    480

tgggtccgcc aggctccagg gaaggggctg gagtggctgg gcgtaatatg gggtagtgaa    540

accacatact ataattcagc tctcaaatcc cgattcacca tcatcaaaga caacgccaag    600

aactcactgt atctgcaaat gaacagcctg agagccgagg acacggctgt gtattactgt    660

gcgaagcatt attactacgg tggtagctat gctatggact actggggcca aggaaccaca    720

gtcaccgtct cctca                                                     735


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  scFvĶ1

<400>  6

Gln Phe Asn Lys Pro Trp Glu His 
1               5               


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  scFvĶ2

<400>  7

Asn Trp Ser His Pro Gln Phe Glu Lys 
1               5                   


<210>  8
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  cFvĶ3

<400>  8

Gln Phe Asn Lys Pro Trp Glu His Phe Glu Lys 
1               5                   10      


<210>  9
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  scFvĶ4

<400>  9

Asn Lys Gly Asn Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10          


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  scFvĶ5

<400>  10

Asn Gln Phe Asn Lys Gly Pro Trp Glu His Trp Ser His Glu Lys 
1               5                   10                  15  


<210>  11
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ1İ

<400>  11

Gln Phe Asn Lys Pro Trp Glu His Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
        115                 120                 125             


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser 
            260             


<210>  12
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ1ĺ

<400>  12
caatttaata aaccttggga acatggtggc ggtggctcgg gcggtggtgg gtcggacatc     60

cagatgacac agactacatc ctccctgtct gcctctctgg gagacagagt caccatcagt    120

tgcagggcaa gtcaggacat tagtaaatat ttaaattggt atcagcagaa accagatgga    180

actgttaaac tcctgatcta ccatacatca agattacact caggagtccc atcaaggttc    240

agtggcagtg ggtctggaac agattattct ctcaccatta gcaacctgga gcaagaagat    300

attgccactt acttttgcca acagggtaat acgcttccgt acacgttcgg aggggggact    360

aagttggaaa taacaggctc cacctctgga tccggcaagc ccggatctgg cgagggatcc    420

accaagggcg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc    480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt    540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca    600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa    660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa    720

cattattact acggtggtag ctatgctatg gactactggg gtcaaggaac ctcagtcacc    780

gtctcctca                                                            789


<210>  13
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ1İ
       

<400>  13

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Phe Asn Lys Pro Trp Glu His Gly Ser Thr 
        115                 120                 125             


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser 
            260             


<210>  14
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ1ĺ
       

<400>  14
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggtggcggt ggctcgggcg gtggtgggtc gcaatttaat    360

aaaccttggg aacatggctc cacctctgga tccggcaagc ccggatctgg cgagggatcc    420

accaagggcg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc    480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt    540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca    600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa    660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa    720

cattattact acggtggtag ctatgctatg gactactggg gtcaaggaac ctcagtcacc    780

gtctcctca                                                            789


<210>  15
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ1İ

<400>  15

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Phe Asn Lys Pro Trp Glu His 
            260             


<210>  16
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ1ĺ

<400>  16
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggctccacc tctggatccg gcaagcccgg atctggcgag    360

ggatccacca agggcgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca    420

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc    480

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa    540

accacatact ataattcagc tctcaaatcc agactgacca tcatcaagga caactccaag    600

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt    660

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca    720

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgcaatt taataaacct    780

tgggaacat                                                            789


<210>  17
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ2İ

<400>  17

Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser 
            260                 


<210>  18
<211>  792
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ2ĺ

<400>  18
aactggagcc acccccagtt cgagaagggt ggcggtggct cgggcggtgg tgggtcggac     60

atccagatga cacagactac atcctccctg tctgcctctc tgggagacag agtcaccatc    120

agttgcaggg caagtcagga cattagtaaa tatttaaatt ggtatcagca gaaaccagat    180

ggaactgtta aactcctgat ctaccataca tcaagattac actcaggagt cccatcaagg    240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagcaacct ggagcaagaa    300

gatattgcca cttacttttg ccaacagggt aatacgcttc cgtacacgtt cggagggggg    360

actaagttgg aaataacagg ctccacctct ggatccggca agcccggatc tggcgaggga    420

tccaccaagg gcgaggtgaa actgcaggag tcaggacctg gcctggtggc gccctcacag    480

agcctgtccg tcacatgcac tgtctcaggg gtctcattac ccgactatgg tgtaagctgg    540

attcgccagc ctccacgaaa gggtctggag tggctgggag taatatgggg tagtgaaacc    600

acatactata attcagctct caaatccaga ctgaccatca tcaaggacaa ctccaagagc    660

caagttttct taaaaatgaa cagtctgcaa actgatgaca cagccattta ctactgtgcc    720

aaacattatt actacggtgg tagctatgct atggactact ggggtcaagg aacctcagtc    780

accgtctcct ca                                                        792


<210>  19
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ2İ
       

<400>  19

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser 
            260                 


<210>  20
<211>  792
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ2ĺ
       

<400>  20
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    360

cacccccagt tcgagaaggg ctccacctct ggatccggca agcccggatc tggcgaggga    420

tccaccaagg gcgaggtgaa actgcaggag tcaggacctg gcctggtggc gccctcacag    480

agcctgtccg tcacatgcac tgtctcaggg gtctcattac ccgactatgg tgtaagctgg    540

attcgccagc ctccacgaaa gggtctggag tggctgggag taatatgggg tagtgaaacc    600

acatactata attcagctct caaatccaga ctgaccatca tcaaggacaa ctccaagagc    660

caagttttct taaaaatgaa cagtctgcaa actgatgaca cagccattta ctactgtgcc    720

aaacattatt actacggtgg tagctatgct atggactact ggggtcaagg aacctcagtc    780

accgtctcct ca                                                        792


<210>  21
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ2İ

<400>  21

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn 
                245                 250                 255     


Trp Ser His Pro Gln Phe Glu Lys 
            260                 


<210>  22
<211>  792
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ2ĺ

<400>  22
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggctccacc tctggatccg gcaagcccgg atctggcgag    360

ggatccacca agggcgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca    420

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc    480

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa    540

accacatact ataattcagc tctcaaatcc agactgacca tcatcaagga caactccaag    600

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt    660

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca    720

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgaactg gagccacccc    780

cagttcgaga ag                                                        792


<210>  23
<211>  266
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ3İ

<400>  23

Gln Phe Asn Lys Pro Trp Glu His Phe Glu Lys Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                165                 170                 175     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        195                 200                 205             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265     


<210>  24
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ3ĺ

<400>  24
caatttaata aaccttggga acatttcgag aagggtggcg gtggctcggg cggtggtggg     60

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    360

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    420

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    480

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    540

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    600

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    660

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    720

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    780

tcagtcaccg tctcctca                                                  798


<210>  25
<211>  266
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ3İ
       

<400>  25

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Phe Asn Lys Pro Trp Glu His Phe Glu Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                165                 170                 175     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        195                 200                 205             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265     


<210>  26
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ3ĺ
       

<400>  26
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggtggcggt ggctcgggcg gtggtgggtc gcaatttaat    360

aaaccttggg aacatttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    420

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    480

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    540

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    600

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    660

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    720

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    780

tcagtcaccg tctcctca                                                  798


<210>  27
<211>  266
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ3İ

<400>  27

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Phe Asn Lys Pro Trp Glu His Phe Glu Lys 
            260                 265     


<210>  28
<211>  798
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ3ĺ

<400>  28
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggctccacc tctggatccg gcaagcccgg atctggcgag    360

ggatccacca agggcgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca    420

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc    480

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa    540

accacatact ataattcagc tctcaaatcc agactgacca tcatcaagga caactccaag    600

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt    660

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca    720

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgcaatt taataaacct    780

tgggaacatt tcgagaag                                                  798


<210>  29
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ4İ

<400>  29

Asn Lys Gly Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210>  30
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ4ĺ

<400>  30
aataaaggta actggtctca tcctcaattt gaaaagggtg gcggtggctc gggcggtggt     60

gggtcggaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc a                                              801


<210>  31
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ4İ
       

<400>  31

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asn Lys Gly Asn Trp Ser His Pro Gln Phe Glu 
        115                 120                 125             


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210>  32
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ4ĺ
       

<400>  32
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggtggcggt ggctcgggcg gtggtgggtc gaataaaggt    360

aactggtctc atcctcaatt tgaaaagggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc a                                              801


<210>  33
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ4İ

<400>  33

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn 
                245                 250                 255     


Lys Gly Asn Trp Ser His Pro Gln Phe Glu Lys 
            260                 265         


<210>  34
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ4ĺ

<400>  34
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggctccacc tctggatccg gcaagcccgg atctggcgag    360

ggatccacca agggcgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca    420

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc    480

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa    540

accacatact ataattcagc tctcaaatcc agactgacca tcatcaagga caactccaag    600

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt    660

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca    720

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgaataa aggtaactgg    780

tctcatcctc aatttgaaaa g                                              801


<210>  35
<211>  270
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ5İ

<400>  35

Asn Gln Phe Asn Lys Gly Pro Trp Glu His Trp Ser His Glu Lys Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
            20                  25                  30          


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265                 270 


<210>  36
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvNĩӱĶ5ĺ

<400>  36
aataaaggta actggtctca tcctcaattt gaaaagggtg gcggtggctc gggcggtggt     60

gggtcggaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc a                                              801


<210>  37
<211>  270
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ5İ
       

<400>  37

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asn Gln Phe Asn Lys Gly Pro Trp Glu His Trp 
        115                 120                 125             


Ser His Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
            180                 185                 190         


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
        195                 200                 205             


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
    210                 215                 220                 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
                245                 250                 255     


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265                 270 


<210>  38
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 
       scFvɱɱĽͷCӱĶ5ĺ
       

<400>  38
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggtggcggt ggctcgggcg gtggtgggtc gaataaaggt    360

aactggtctc atcctcaatt tgaaaagggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc a                                              801


<210>  39
<211>  270
<212>  PRT
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ5İ

<400>  39

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn 
                245                 250                 255     


Gln Phe Asn Lys Gly Pro Trp Glu His Trp Ser His Glu Lys 
            260                 265                 270 


<210>  40
<211>  801
<212>  DNA
<213>  Artificial

<220>
<223>  FMC63 scFvCĩӱĶ5ĺ

<400>  40
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggactaagt tggaaataac aggctccacc tctggatccg gcaagcccgg atctggcgag    360

ggatccacca agggcgaggt gaaactgcag gagtcaggac ctggcctggt ggcgccctca    420

cagagcctgt ccgtcacatg cactgtctca ggggtctcat tacccgacta tggtgtaagc    480

tggattcgcc agcctccacg aaagggtctg gagtggctgg gagtaatatg gggtagtgaa    540

accacatact ataattcagc tctcaaatcc agactgacca tcatcaagga caactccaag    600

agccaagttt tcttaaaaat gaacagtctg caaactgatg acacagccat ttactactgt    660

gccaaacatt attactacgg tggtagctat gctatggact actggggtca aggaacctca    720

gtcaccgtct cctcaggtgg cggtggctcg ggcggtggtg ggtcgaataa aggtaactgg    780

tctcatcctc aatttgaaaa g                                              801


<210>  41
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CAR4-1BB̼ź򰱻УWT

<400>  41

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  42
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CAR4-1BB̼ź

<400>  42
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag     60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc    120

gagctg                                                               126


<210>  43
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CAR B1̼ź򰱻

<400>  43

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Gln Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  44
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CAR B1̼ź

<400>  44
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag     60

accacccagg aggaggacgg ctgcagctgc cgcttccccg agcaggagga gggcggctgc    120

gagctg                                                               126


<210>  45
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CAR B2̼ź򰱻

<400>  45

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Pro Thr Glu Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Thr Glu Gln Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  46
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CAR B2̼ź

<400>  46
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag     60

cccaccgagg aggaggacgg ctgcagctgc cgcttcaccg agcaggagga gggcggctgc    120

gagctg                                                               126


<210>  47
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CAR B3̼ź򰱻

<400>  47

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Phe Pro Glu Glu Glu Glu Asp Gly Cys Ser Cys Arg Gln 
            20                  25                  30          


Thr Thr Gln Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  48
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CAR B3̼ź

<400>  48
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgttc     60

cccgaggagg aggaggacgg ctgcagctgc cgccagacca cccaggagga gggcggctgc    120

gagctg                                                               126


<210>  49
<211>  53
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CAR B4̼ź򰱻

<400>  49

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gln Thr Thr Gln Glu 
        35                  40                  45              


Glu Asp Gly Cys Ser 
    50              


<210>  50
<211>  159
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CAR B4̼ź

<400>  50
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag     60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc    120

gagctggtgc agaccaccca ggaggaggac ggctgcagc                           159


<210>  51
<211>  53
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CAR B5̼ź򰱻

<400>  51

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Asp Leu Ala Met Ala Asp 
        35                  40                  45              


Leu Glu Gln Lys Val 
    50              


<210>  52
<211>  159
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CAR B5̼ź

<400>  52
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag     60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc    120

gagctggacc tggcgatggc tgacttggag cagaaggtc                           159


<210>  53
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BBӵ1

<400>  53

Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BBӵ2

<400>  54

Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  4-1BBӵ3

<400>  55

Asp Leu Ala Met Ala Asp Leu Glu Gln Lys Val 
1               5                   10      


<210>  56
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CARCD3ź򰱻УWT

<400>  56

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  57
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CARCD3ź

<400>  57
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc    120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat    180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc    240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc    300

tacgacgccc ttcacatgca ggccctgccc cctcgc                              336


<210>  58
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CARCD3 M1ź򰱻

<400>  58

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Lys Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  59
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CARCD3 M1ź

<400>  59
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agaagggcca gaaccagctc     60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc    120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat    180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc    240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc    300

tacgacgccc ttcacatgca ggccctgccc cctcgc                              336


<210>  60
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CARCD3 M2ź򰱻

<400>  60

Arg Leu Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Lys Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  61
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CARCD3 M2ź

<400>  61
agactgaagt tcagcaggag cgcagacgcc cccgcgtacc agaagggcca gaaccagctc     60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc    120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat    180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc    240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc    300

tacgacgccc ttcacatgca ggccctgccc cctcgc                              336


<210>  62
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CARCD3 M3ź򰱻

<400>  62

Arg Leu Lys Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  63
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CARCD3 M3ź

<400>  63
agactgaagt tcagcaggag cgcagaggcc cccgcgtacc agaagggcca gaaccagctc     60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc    120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat    180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc    240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc    300

tacgacgccc ttcacatgca ggccctgccc cctcgc                              336


<210>  64
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CARCD3 M4ź򰱻

<400>  64

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  65
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CARCD3 M4ź

<400>  65
cgcgtgaagt tcagccgcag cgccgacgcc cccgcctaca agcagggcca gaaccagctg     60

tacaacgagc tgaacctggg ccgccgcgag gagtacgacg tgctggacaa gcgccgcggc    120

cgcgaccccg agatgggcgg caagccccgc cgcaagaacc cccaggaggg cctgtacaac    180

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgc    240

cgccgcggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggacacc    300

tacgacgccc tgcacatgca ggccctgccc ccccgc                              336


<210>  66
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD19 CARCD3 M5ź򰱻

<400>  66

Arg Leu Lys Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  67
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD19 CARCD3M5ź

<400>  67
cgcctgaagt tcagccgcag cgccgaggcc cccgcctacc agaagggcca gaaccagctg     60

tacaacgagc tgaacctggg ccgccgcgag gagtacgacg tgctggacaa gcgccgcggc    120

cgcgaccccg agatgggcgg caagccccgc cgcaagaacc cccaggaggg cctgtacaac    180

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgc    240

cgccgcggca agggccacga cggcctgttc cagggcctga gcaccgccac caaggacacc    300

tacgacgcct accgccacca ggccctgccc ccccgc                              336


<210>  68
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-1

<400>  68

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Phe Thr Ile Ile Lys Asp Asn Ala Lys Asn Ser 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  69
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-1

<400>  69
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga    120

gtcaccatca cttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccaggga aagcccctaa gctcctgatc tatcatacat caagattaca ctcaggggtc    240

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg    300

caacctgaag attttgcaac ttactactgt caacagggta atacgcttcc gtacacgttc    360

ggagggggga ccaaggtgga gatcaaaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgcag ctggtggagt ctgggggagg cttggtccag    480

cctggggggt ccctgagact ctcctgtgca gcctctgggg tctcattacc cgactatggt    540

gtaagctggg tccgccaggc tccagggaag gggctggagt ggctgggcgt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatcccgat tcaccatcat caaagacaac    660

gccaagaact cactgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtgtat    720

tactgtgcga agcattatta ctacggtggt agctatgcta tggactactg gggccaagga    780

accacagtca ccgtctcctc aaccaccacc ccagcccccc gaccaccaac acccgccccc    840

accatcgcca gccagcccct gagcctgcgc cccgaggcct gccgccccgc cgccggcggc    900

gccgtgcaca cccgcggcct ggacttcgcc tgcgacatct acatctgggc ccccctggcc    960

ggcacctgcg gcgtgctgct gctgagcctg gtgatcaccc tgtactgcaa gcgcggccgc   1020

aagaagctgc tgtacatctt caagcagccc ttcatgcgcc ccgtgcagac cacccaggag   1080

gaggacggct gcagctgccg cttccccgag gaggaggagg gcggctgcga gctgcgcgtg   1140

aagttcagcc gcagcgccga cgcccccgcc tacaagcagg gccagaacca gctgtacaac   1200

gagctgaacc tgggccgccg cgaggagtac gacgtgctgg acaagcgccg cggccgcgac   1260

cccgagatgg gcggcaagcc ccgccgcaag aacccccagg agggcctgta caacgagctg   1320

cagaaggaca agatggccga ggcctacagc gagatcggca tgaagggcga gcgccgccgc   1380

ggcaagggcc acgacggcct gtaccagggc ctgagcaccg ccaccaagga cacctacgac   1440

gccctgcaca tgcaggccct gcccccccgc taa                                1473


<210>  70
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-2

<400>  70

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  71
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-2

<400>  71
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gcgcgtgaag   1200

ttcagccgca gcgccgacgc ccccgcctac aagcagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

ctgcacatgc aggccctgcc cccccgctaa                                    1530


<210>  72
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-3

<400>  72

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  73
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-3

<400>  73
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gcgcgtgaag   1200

ttcagccgca gcgccgacgc ccccgcctac aagcagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

ctgcacatgc aggccctgcc cccccgctaa                                    1530


<210>  74
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-4

<400>  74

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  75
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-4

<400>  75
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gcgcgtgaag   1200

ttcagccgca gcgccgacgc ccccgcctac aagcagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

ctgcacatgc aggccctgcc cccccgctaa                                    1530


<210>  76
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-5

<400>  76

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  77
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-5

<400>  77
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgagcag gaggagggcg gctgcgagct gcgcgtgaag   1200

ttcagccgca gcgccgacgc ccccgcctac aagcagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

ctgcacatgc aggccctgcc cccccgctaa                                    1530


<210>  78
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-6

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Pro Thr Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Thr Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  79
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-6

<400>  79
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagcccac cgaggaggag   1140

gacggctgca gctgccgctt caccgagcag gaggagggcg gctgcgagct gcgcgtgaag   1200

ttcagccgca gcgccgacgc ccccgcctac aagcagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

ctgcacatgc aggccctgcc cccccgctaa                                    1530


<210>  80
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-7

<400>  80

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Phe Pro Glu Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Gln Thr Thr Gln Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  81
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-7

<400>  81
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgttccccga ggaggaggag   1140

gacggctgca gctgccgcca gaccacccag gaggagggcg gctgcgagct gcgcgtgaag   1200

ttcagccgca gcgccgacgc ccccgcctac aagcagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgta ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

ctgcacatgc aggccctgcc cccccgctaa                                    1530


<210>  82
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-8

<400>  82

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gln Thr 
385                 390                 395                 400 


Thr Gln Glu Glu Asp Gly Cys Ser Arg Val Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  83
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-8

<400>  83
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggtgcagacc   1200

acccaggagg aggacggctg cagccgcgtg aagttcagcc gcagcgccga cgcccccgcc   1260

tacaagcagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gtaccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gcccccccgc   1560

taa                                                                 1563


<210>  84
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-9

<400>  84

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Met Ala Asp Leu Glu Gln Lys Val Arg Val Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  85
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-9

<400>  85
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggacctggcg   1200

atggctgact tggagcagaa ggtccgcgtg aagttcagcc gcagcgccga cgcccccgcc   1260

tacaagcagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gtaccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gccctgcaca tgcaggccct gcccccccgc   1560

taa                                                                 1563


<210>  86
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-10

<400>  86

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  87
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-10

<400>  87
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gagagtgaag   1200

ttcagcagga gcgcagacgc ccccgcgtac cagaagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa                                    1530


<210>  88
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-11

<400>  88

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  89
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-11

<400>  89
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gagactgaag   1200

ttcagcagga gcgcagacgc ccccgcgtac cagaagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa                                    1530


<210>  90
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-12

<400>  90

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  91
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-12

<400>  91
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gagactgaag   1200

ttcagcagga gcgcagaggc ccccgcgtac cagaagggcc agaaccagct ctataacgag   1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct   1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag   1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc   1440

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac ctacgacgcc   1500

cttcacatgc aggccctgcc ccctcgctaa                                    1530


<210>  92
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-13

<400>  92

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  93
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-13

<400>  93
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgagcag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  94
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-14

<400>  94

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Pro Thr Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Thr Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  95
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-14

<400>  95
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagcccac cgaggaggag   1140

gacggctgca gctgccgctt caccgagcag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  96
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-15

<400>  96

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Phe Pro Glu Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Gln Thr Thr Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  97
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-15

<400>  97
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgttccccga ggaggaggag   1140

gacggctgca gctgccgcca gaccacccag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  98
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-16

<400>  98

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gln Thr 
385                 390                 395                 400 


Thr Gln Glu Glu Asp Gly Cys Ser Arg Leu Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Tyr 
            500                 505                 510         


Arg His Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  99
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-16

<400>  99
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggtgcagacc   1200

acccaggagg aggacggctg cagccgcctg aagttcagcc gcagcgccga ggcccccgcc   1260

taccagaagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gttccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gcctaccgcc accaggccct gcccccccgc   1560

taa                                                                 1563


<210>  100
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-17

<400>  100

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Met Ala Asp Leu Glu Gln Lys Val Arg Leu Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Tyr 
            500                 505                 510         


Arg His Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  101
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-17

<400>  101
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggacctggcg   1200

atggctgact tggagcagaa ggtccgcctg aagttcagcc gcagcgccga ggcccccgcc   1260

taccagaagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gttccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gcctaccgcc accaggccct gcccccccgc   1560

taa                                                                 1563


<210>  102
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-18

<400>  102

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  103
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-18

<400>  103
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  104
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-19

<400>  104

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  105
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-19

<400>  105
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgagcag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  106
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-20

<400>  106

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Pro Thr Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Thr Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  107
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-20

<400>  107
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagcccac cgaggaggag   1140

gacggctgca gctgccgctt caccgagcag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  108
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-21

<400>  108

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Phe Pro Glu Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Gln Thr Thr Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  109
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-21

<400>  109
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgttccccga ggaggaggag   1140

gacggctgca gctgccgcca gaccacccag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  110
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-22

<400>  110

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gln Thr 
385                 390                 395                 400 


Thr Gln Glu Glu Asp Gly Cys Ser Arg Leu Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Tyr 
            500                 505                 510         


Arg His Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  111
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-22

<400>  111
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggtgcagacc   1200

acccaggagg aggacggctg cagccgcctg aagttcagcc gcagcgccga ggcccccgcc   1260

taccagaagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gttccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gcctaccgcc accaggccct gcccccccgc   1560

taa                                                                 1563


<210>  112
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-23

<400>  112

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Ser His Pro 
    130                 135                 140                 


Gln Phe Glu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Met Ala Asp Leu Glu Gln Lys Val Arg Leu Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Tyr 
            500                 505                 510         


Arg His Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  113
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-23

<400>  113
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggt ggcggtggct cgggcggtgg tgggtcgaac    420

tggagccacc cccagttcga gaagggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggacctggcg   1200

atggctgact tggagcagaa ggtccgcctg aagttcagcc gcagcgccga ggcccccgcc   1260

taccagaagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gttccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gcctaccgcc accaggccct gcccccccgc   1560

taa                                                                 1563


<210>  114
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-24

<400>  114

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  115
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-24

<400>  115
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  116
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-25

<400>  116

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  117
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-25

<400>  117
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgagcag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  118
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-26

<400>  118

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Pro Thr Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Thr Glu Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  119
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-26

<400>  119
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagcccac cgaggaggag   1140

gacggctgca gctgccgctt caccgagcag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  120
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-27

<400>  120

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Phe Pro Glu Glu Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Gln Thr Thr Gln Glu Glu Gly Gly Cys Glu Leu Arg Leu Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  121
<211>  1530
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-27

<400>  121
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgttccccga ggaggaggag   1140

gacggctgca gctgccgcca gaccacccag gaggagggcg gctgcgagct gcgcctgaag   1200

ttcagccgca gcgccgaggc ccccgcctac cagaagggcc agaaccagct gtacaacgag   1260

ctgaacctgg gccgccgcga ggagtacgac gtgctggaca agcgccgcgg ccgcgacccc   1320

gagatgggcg gcaagccccg ccgcaagaac ccccaggagg gcctgtacaa cgagctgcag   1380

aaggacaaga tggccgaggc ctacagcgag atcggcatga agggcgagcg ccgccgcggc   1440

aagggccacg acggcctgtt ccagggcctg agcaccgcca ccaaggacac ctacgacgcc   1500

taccgccacc aggccctgcc cccccgctaa                                    1530


<210>  122
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-28

<400>  122

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gln Thr 
385                 390                 395                 400 


Thr Gln Glu Glu Asp Gly Cys Ser Arg Leu Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Tyr 
            500                 505                 510         


Arg His Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  123
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-28

<400>  123
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggtgcagacc   1200

acccaggagg aggacggctg cagccgcctg aagttcagcc gcagcgccga ggcccccgcc   1260

taccagaagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gttccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gcctaccgcc accaggccct gcccccccgc   1560

taa                                                                 1563


<210>  124
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-29

<400>  124

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Asp Leu Ala 
385                 390                 395                 400 


Met Ala Asp Leu Glu Gln Lys Val Arg Leu Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Glu Ala Pro Ala Tyr Gln Lys Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Tyr 
            500                 505                 510         


Arg His Gln Ala Leu Pro Pro Arg 
        515                 520 


<210>  125
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-29

<400>  125
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga    120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag    180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc    240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg    300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc    360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct    420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg    480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt    540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt    600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac    660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac    720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga    780

acctcagtca ccgtctcctc aggtggcggt ggctcgggcg gtggtgggtc gaactggagc    840

cacccccagt tcgagaagac caccacccca gccccccgac caccaacacc cgcccccacc    900

atcgccagcc agcccctgag cctgcgcccc gaggcctgcc gccccgccgc cggcggcgcc    960

gtgcacaccc gcggcctgga cttcgcctgc gacatctaca tctgggcccc cctggccggc   1020

acctgcggcg tgctgctgct gagcctggtg atcaccctgt actgcaagcg cggccgcaag   1080

aagctgctgt acatcttcaa gcagcccttc atgcgccccg tgcagaccac ccaggaggag   1140

gacggctgca gctgccgctt ccccgaggag gaggagggcg gctgcgagct ggacctggcg   1200

atggctgact tggagcagaa ggtccgcctg aagttcagcc gcagcgccga ggcccccgcc   1260

taccagaagg gccagaacca gctgtacaac gagctgaacc tgggccgccg cgaggagtac   1320

gacgtgctgg acaagcgccg cggccgcgac cccgagatgg gcggcaagcc ccgccgcaag   1380

aacccccagg agggcctgta caacgagctg cagaaggaca agatggccga ggcctacagc   1440

gagatcggca tgaagggcga gcgccgccgc ggcaagggcc acgacggcct gttccagggc   1500

ctgagcaccg ccaccaagga cacctacgac gcctaccgcc accaggccct gcccccccgc   1560

taa                                                                 1563


<210>  126
<211>  505
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-30

<400>  126

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg 
        195                 200                 205             


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr 
    210                 215                 220                 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser 
225                 230                 235                 240 


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr 
                245                 250                 255     


Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala 
            260                 265                 270         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ile Glu 
        275                 280                 285             


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
    290                 295                 300                 


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
305                 310                 315                 320 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
                325                 330                 335     


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            340                 345                 350         


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
        355                 360                 365             


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
    370                 375                 380                 


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505 


<210>  127
<211>  1518
<212>  DNA
<213>  Artificial

<220>
<223>  CAR-30

<400>  127
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg     60

atcccaaact ggagccaccc ccagttcgag aagggtggcg gtggctcggg cggtggtggg    120

tcggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc    180

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa    240

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca    300

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag    360

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga    420

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc    480

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc    540

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta    600

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt    660

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc    720

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac    780

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc    840

tcagtcaccg tctcctcaat tgaagttatg tatcctcctc cttacctaga caatgagaag    900

agcaatggaa ccattatcca tgtgaaaggg aaacaccttt gtccaagtcc cctatttccc    960

ggaccttcta agcccttttg ggtgctggtg gtggttgggg gagtcctggc ttgctatagc   1020

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg   1080

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag   1140

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc   1200

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga   1260

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga   1320

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg   1380

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat   1440

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag   1500

gccctgcccc ctcgctaa                                                 1518


<210>  128
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  11D5-3 scFvNĩӱ2İ

<400>  128

Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met 
            20                  25                  30          


Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys 
145                 150                 155                 160 


Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr 
        195                 200                 205             


Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala 
    210                 215                 220                 


Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala 
225                 230                 235                 240 


Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265 


<210>  129
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  GC33 scFvNĩӱ2İ

<400>  129

Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln 
        195                 200                 205             


Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr 
    210                 215                 220                 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  130
<211>  487
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-31

<400>  130

Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly 
    130                 135                 140                 


Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
                165                 170                 175     


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
            180                 185                 190         


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
        195                 200                 205             


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
    210                 215                 220                 


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  131
<211>  488
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-32

<400>  131

Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met 
            20                  25                  30          


Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly 
65                  70                  75                  80  


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys 
145                 150                 155                 160 


Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr 
        195                 200                 205             


Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala 
    210                 215                 220                 


Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala 
225                 230                 235                 240 


Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  132
<211>  480
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-33

<400>  132

Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            180                 185                 190         


Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln 
        195                 200                 205             


Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr 
    210                 215                 220                 


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
            260                 265                 270         


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
        275                 280                 285             


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
    290                 295                 300                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
305                 310                 315                 320 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                325                 330                 335     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            340                 345                 350         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360                 365             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    370                 375                 380                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
385                 390                 395                 400 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            420                 425                 430         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        435                 440                 445             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    450                 455                 460                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475                 480 


<210>  133
<211>  489
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-34

<400>  133

Gln Phe Asn Lys Pro Trp Glu His Phe Glu Lys Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                165                 170                 175     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        195                 200                 205             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  134
<211>  488
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-35

<400>  134

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asn Trp Ser His Pro Gln Phe Glu Lys Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  135
<211>  486
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-36

<400>  135

Asn Gln Phe Asn Lys Gly Pro Trp Glu His Trp Ser His Glu Lys Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 
            20                  25                  30          


Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
        35                  40                  45              


Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
    50                  55                  60                  


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys 
65                  70                  75                  80  


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
            100                 105                 110         


Val Gly Val Tyr Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe 
        115                 120                 125             


Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
145                 150                 155                 160 


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
                165                 170                 175     


Ser Gly Tyr Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Gln Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly 
        195                 200                 205             


Asp Thr Ala Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala 
    210                 215                 220                 


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met Tyr 
            260                 265                 270         


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
        275                 280                 285             


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
    290                 295                 300                 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
305                 310                 315                 320 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  136
<211>  468
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-37

<400>  136

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
    290                 295                 300                 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                325                 330                 335     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            340                 345                 350         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg 
465             


<210>  137
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-38

<400>  137

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                245                 250                 255     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            260                 265                 270         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        275                 280                 285             


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
    290                 295                 300                 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
305                 310                 315                 320 


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
                325                 330                 335     


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            340                 345                 350         


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        355                 360                 365             


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    370                 375                 380                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
385                 390                 395                 400 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg 
465                 


<210>  138
<211>  461
<212>  PRT
<213>  Artificial

<220>
<223>  CAR-39

<400>  138

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
                245                 250                 255     


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            260                 265                 270         


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
        275                 280                 285             


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
    290                 295                 300                 


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
305                 310                 315                 320 


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
                325                 330                 335     


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460     


